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Dissertations / Theses on the topic 'Gene Array'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Li, Yan 1978 July 15. "Gene expression array simulator." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/87263.

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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 2002.<br>"May 10, 2002.<br>Includes bibliographical references (leaf 141).<br>by Yan Li.<br>M.Eng.

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2

Mapiye, Darlington S. "Normalization and statistical methods for crossplatform expression array analysis." University of the Western Cape, 2012. http://hdl.handle.net/11394/4586.

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>Magister Scientiae - MSc<br>A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel in-silico analyses that would otherwise be too costly to perform or for which the equivalent sample numbers would be difficult to collects exists. For example, combining and re-analysing large numbers of data sets from the same cancer type would increase statistical power, while the effects of individual study-specific variability is weakened, whic

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3

Lundén, Karl. "Heterobasidion - conifer pathosystem : heterologous array analysis and transcriptional shift from saprotrophic to necrotrophic growth /." Uppsala : Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, 2010. http://epsilon.slu.se/201019.pdf.

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4

Norouzi, Masoud. "Development of an RNA array to Protein array (RAPA) platform and its application to gene expression analysis of synthetic riboregulators." Thesis, University of Portsmouth, 2018. https://researchportal.port.ac.uk/portal/en/theses/development-of-an-rna-array-to-protein-array-rapa-platform-and-its-application-to-gene-expression-analysis-of-synthetic-riboregulators(5867a39c-55a4-410a-8e5a-53c347b8a81a).html.

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5

Bjork, Kathe Elizabeth. "Robust identification of differential gene expression and discrimination /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Thesis (Ph.D. in Biostatistics) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 237-239). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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6

Araujo, Tânia Kawasaki de 1985. "Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313118.

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Orientador: Vera Lúcia Gil da Silva Lopes<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T00:02:24Z (GMT). No. of bitstreams: 1 Araujo_TaniaKawasakide_D.pdf: 3447671 bytes, checksum: 97911848c6334882843e4b270b9c6771 (MD5) Previous issue date: 2015<br>Resumo: A fenda de labiopalatal (FLP) isolada é o defeito craniofacial mais comum em humanos. O objetivo deste estudo foi avaliar associações entre 39 genes e a etiologia de FLP isolada em uma amostra da população brasileira. Este estudo de associação do tipo caso-c

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7

Arlinde, Christina. "Gene expression profiling in animal models of alcoholism /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-133-4/.

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8

Sandgren, Johanna. "Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129533.

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The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. Apart from DNA-rearrangements, epigenomic changes are increasingly acknowledged as important events in the maintenance of genomic integrity. In this thesis, different array-based methods have been applied for global genomic and epigenomic profiling of both normal and cancer

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9

Dumas, Laura Jane. "Gene copy number variation in human and primate evolution /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008. http://proquest.umi.com/pqdweb?did=1545571861&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 98-112). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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10

Tong, Lily. "Probing the function of RNase E family using biochemical techniques and gene array technology." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414514.

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11

Fouriki, Angeliki. "Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine." Thesis, Keele University, 2017. http://eprints.keele.ac.uk/4280/.

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Successful gene therapy depends upon specific gene delivery into the cells and tissues of interest. Nanomagnetic gene transfection is a relatively new gene delivery technique that has attempted to meet that need and has been effectively used with both viral and non-viralvector systems. It uses magnetic nanoparticles (MNPs) in assisting and directing specific delivery of reporter or therapeutic genes on a single cell basis, in the presence of an externally introduced oscillating magnet. The novelty of the lateral oscillation further stimulates endocytosis of MNP:plasmid complexes with improved

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12

Qin, Li-Xuan. "The clustering of regression models method with applications in gene expression data /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9591.

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13

Goh, Xin Yi. "Integrative analysis of array comparative genomic hybridisation and microarray gene expression profiles in oesophageal adenocarcinoma." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609976.

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14

Marincevic, Millaray. "Array-based Characterization of Chronic Lymphocytic Leukemia : - with Focus on Subsets Carrying Stereotyped B-cell Receptors." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132895.

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In chronic lymphocytic leukemia (CLL), the presence of multiple subsets expressing ‘stereotyped’ B-cell receptors (BCRs) has implicated antigen(s) in leukemogenesis. These stereotyped subsets display similar immunoglobulin (IG) gene usage, almost identical complementarity determining region 3’s and may share clinical features. For instance, subsets #1 (IGHV1/5/7/IGKV1-39) and #2 (IGHV3-21/IGLV3-21) have inferior outcome compared to non-subset patients, whereas subset #4 (IGHV4-34/IGKV2-30) display a favourable prognosis. The aim of this thesis was to investigate genomic aberrations, gene expre

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15

Fält, Susann. "Analysis of global gene expression in complex biological systems using microarray technology /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-612-3/.

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16

Kardooni, Hoda. "Epigenetic silencing of gene expression in paediatric malignant astrocytoma." Thesis, University of Wolverhampton, 2015. http://hdl.handle.net/2436/615001.

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Brain tumours account for the most frequent type of solid tumours among children. Despite advances in surgery and chemotherapy, brain tumours are still the main cause of cancer deaths in children. Furthermore, little is known about DNA methylation changes in paediatric astrocytoma. Recent investigations suggest that many tumours are initiated not only by genetic abnormalities, but also caused by epigenetic changes. DNA methylation is a key epigenetic mechanism that controls the regulation of gene expression. Interestingly, unlike DNA mutations, epigenetic abnormalities are reversible. The reve

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17

Urbich, Carmen. "Identifizierung neuer Schubspannungs-regulierter Gene mittels "Atlas cDNA Expression Array" Bedeutung für die Funktion von Endothelzellen /." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961909625.

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18

Xue-Franzén, Yongtao. "DNA microarray approaches to understanding the regulation and evolution of gene expression networks." Stockholm : Huddinge : Karolinska institutet ; Södertörns högskola, 2009. http://diss.kib.ki.se/2009/978-91-7409-554-8/.

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19

Wylie, Christi J. "Distinct Transcriptomes Define Rostral and Caudal 5HT Neurons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1266002785.

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20

Mellick, Albert S. Jr, and n/a. "Tissue Specific Gene Expression Patterning and Carcinogenesis." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041102.114313.

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Despite significant advances in diagnosis and treatment, breast cancer remains the leading cause of cancer-related deaths in Australian women. Colorectal cancer is the second most common cancer in both males and females; after prostate and breast cancer, respectively, and excluding non-melanocytic skin cancer. Both breast cancer and colorectal cancer follow a common progressive course of illness; presenting (at least initially) with benign symptoms that can be treated by ablation (or removal) of the affected area. Cancer progression is associated with breakdown of tissue barriers (such as base

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21

Mellick, Albert S. Jr. "Tissue Specific Gene Expression Patterning and Carcinogenesis." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365189.

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Despite significant advances in diagnosis and treatment, breast cancer remains the leading cause of cancer-related deaths in Australian women. Colorectal cancer is the second most common cancer in both males and females; after prostate and breast cancer, respectively, and excluding non-melanocytic skin cancer. Both breast cancer and colorectal cancer follow a common progressive course of illness; presenting (at least initially) with benign symptoms that can be treated by ablation (or removal) of the affected area. Cancer progression is associated with breakdown of tissue barriers (such as base

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22

Dimassi, Sarra. "Identification de gènes responsables d'épilepsies de l'enfant." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1114.

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L'épilepsie est une affection neurologique chronique qui se définit par la répétition de crises épileptiques, signe de l'hyperactivité paroxystique d'un groupe de neurones corticaux. Ces dernières années, plusieurs gènes responsables d'épilepsies monogéniques ont été mis en évidence. Notre travail avait pour objectif l'identification d'anomalies génétiques responsables ou favorisants certaines formes d'épilepsies de l'enfant. Ce travail est composé de quatre études complémentaires. La première était l'exploration pangénomique d'une cohorte de 47 patients porteurs d'épilepsie à paroxysme roland

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23

Mehta, Shaveta. "Biomarkers of anti-angiogenic therapy in breast cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8b3869e3-fd60-450c-b165-0fe773681613.

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The hunt for biomarkers for anti-VEGF agent bevacizumab is ongoing since last decade with no success. Identifying robust biomarkers for stratifying patients and for monitoring response is important for the future use of bevacizumab in breast cancer. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) analysis and genome wide gene expression analysis are two promising approaches to understand the molecular mechanisms and search for biomarker of anti-angiogenic therapy. Firstly, with the retrospective pilot study, a close link between DCE-MRI findings and the molecular mechanisms assi

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24

Holst, Martin Ingo. "Identifikation und Charakterisierung differenziell exprimierter Gene in einer Mausmutanten mit prolongierter Engrailed-2 Expression mithilfe der Array-Technologie." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=985081120.

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25

Suzuki, Keli Tieko. "Investigação molecular por sequenciamento do gene CBP em portadores da síndrome de Rubinstein-Taybi." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24052012-154642/.

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A Síndrome de Rubinstein-Taybi (RTSs) é uma doença rara de herança autossômica dominante, caracterizada por dismorfismos craniofaciais, polegares e háluces alargados, deficiência intelectual e de crescimento. RTSs tem sido associada com mutações no gene CREBBP (CBP) e mutações menos frequentes no gene EP300 que foram descritas em oito indivíduos. CBP e p300 possuem alta homologia e são extremamente importantes em várias vias de sinalização, principalmente como coativadores de transcrição e na acetilação das histonas. Nosso estudo baseou-se na análise de alterações moleculares por sequenciament

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26

Levy, Mark. "The role of dietary zinc and CuZnSOD gene expression in response to oxidative stress in the lung and brain." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054069625.

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27

Michael, Bindhu. "Human T lymphotropic virus type 1 (HTLV-1) accessory protein p30(II) modulates cellular and viral gene expression." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1088784889.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 250 p.; also includes graphics (some col.) Includes bibliographical references (p. 207-250). Available online via OhioLINK's ETD Center

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28

Wennmalm, Kristian. "Analytical strategies for identifying relevant phenotypes in microarray data /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-401-3/.

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29

Delgado, Verdugo Alberto. "Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224111.

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Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. This opens the question if there exists a single or several endocrine tumor genes. The aim of the study was to describe genetic derangements in endocrine tumors. Paper I: Investigation of mutational status of SDHAF2 in parathyroid tumors. SDHAF2 is located in t

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30

Wagner, Brandie D. "Permutation based microarray gene selection methods with covarience adjustment applicable to complex diseases /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Analytic Health Sciences) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 57-60). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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31

Zhou, Chuan. "A Bayesian model for curve clustering with application to gene expression data analysis /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/9576.

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32

Lewis, Tyler E. "Investigation of Parameters Affecting the Nanoinjection of HeLa 229 Cancer Cells." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5526.

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The ability to deliver sequences of DNA and other molecular loads across the membrane of a cell and into its nucleus is an area of interest in the medical community. One of its many applications is that of gene therapy. In contrast to other forms of treatment, gene therapy seeks to treat diseases at the cellular level. The success of these treatments depends on the technologies for cell transfection that are available. Physical methods are sometimes able to overcome poor efficiencies of chemical methods and the safety concerns of viral methods, but are usually impractical due to the limited nu

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33

Finnell, Jordan Grant. "Anthrax, Matrix Biology, and Angiogenesis: Capillary Morphogenesis Gene 2 Mediates Activity and Uptake of Type IV Collagen-Derived Anti-Angiogenic Peptides." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6849.

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Capillary Morphogenesis Gene 2 (CMG2) is a type I transmembrane, integrin-like receptor. It was originally identified as one of several genes upregulated during capillary formation. It was subsequently identified as one of two physiological anthrax toxin receptors, where CMG2 serves as a cell-surface receptor for anthrax toxin and mediates entry of the toxin into cells via clathrin-dependent endocytosis. Additionally, loss-of-function mutations in CMG2 cause the genetic disorder hyaline fibromatosis syndrome (HFS), where the core symptom is dysregulation of extracellular matrix homeostasis (EC

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34

Nair, Amrithraj Muraleedharan. "Studies of retroviral vectors for in utero gene transfer and investigation of calcium-mediated gene regulation by Human T-lymphotropic virus type-1." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1088785797.

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35

Wu, Ling. "Functional Characterization of SCN5A, The Cardiac Sodium Channel Gene Associated With Cardiac Arrhythmias and Sudden Death." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1206732295.

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36

Libby, Eric. "Investigations into the design and dissection of genetic networks." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103265.

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The sequencing of the human genome revealed that the number of genes does not explain why humans are different from other organisms like mice and dogs. Instead, it is how genes interact with each other and the environment that separates us from other organisms. This motivates the study of genetic networks and, consequently, my research. My work delves into the roles that simple genetic networks play in a cell and explores the biotechnological aspects of how to uncover such genes and their interactions in experimental models.<br>Cells must respond to the extracellular environment to contract, m

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37

Suryo, Rahmanto Yohan. "THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF MELANOTRANSFERRIN." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2439.

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Melanotransferrin or melanoma tumour antigen p97 (MTf) is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosylphosphatidylinositol anchor. The molecule is a member of the transferrin super-family that binds iron through a single high affinity iron(III)-binding site. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. In fact, considering the cru

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38

Suryo, Rahmanto Yohan. "THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF MELANOTRANSFERRIN." Faculty Medicine, Department of Pathology, 2007. http://hdl.handle.net/2123/2439.

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Doctor of Philosophy(PhD)<br>Melanotransferrin or melanoma tumour antigen p97 (MTf) is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosylphosphatidylinositol anchor. The molecule is a member of the transferrin super-family that binds iron through a single high affinity iron(III)-binding site. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport.

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39

de, Sousa Emma Louise. "The use of novel xenografting methods to reveal differential gene expression between breast cancer at primary and metastatic sites." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:20c957a8-68c7-43f1-b0f6-722ae71dfb5a.

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In developed countries, breast cancer is the commonest malignancy among women. Understanding the mechanisms involved in breast cancer progression and the influence of the microenvironment on cancer cell proliferation, results in better treatments. This study aimed to optimise breast cancer xenograft rates using a novel chamber developed for tissue engineering purposes. The established tumours were subjected to enzyme digestion, creating a single cell suspension, which was then injected into immunocompromised mice at primary, metastatic and intra-cardiac sites. The resulting tumours in the mamm

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40

Morice-Picard, Fanny. "Etude clinique et génétique de l’albinisme oculocutané : développement d’outils de diagnostic moléculaire et recherche de nouveaux gènes." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22101/document.

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Notre travail s’est intéressé à l’albinisme oculocutané en étudiant ses aspects clinico- moléculaires. Malgré l’analyse approfondie des gènes connus d’albinisme oculocutané, 15 % des patients restent sans mutation identifiée indiquant que les mutations sont situées dans des régions géniques non analysées par les techniques classiques de diagnostic moléculaire, ou qu’il existe d’autres gènes d’albinisme oculocutané. Nous avons établi une base de données clinico- biologiques décrivant les caractéristiques de plus de 400 patients analysés. Des outils de diagnostic moléculaire ont été développés à

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41

Landes, Nico. "Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions." Phd thesis, [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975679473.

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42

Larsson, Ola. "Transcriptome studies of cell-fate and aging /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-296-9/.

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43

Hodges, Emily Carol. "High resolution genomic tools for the discovery of protein function in mammalian cells /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-775-8/.

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44

Marshall, Jean-Claude. "Transcriptional and genetic profiling of human uveal melanoma from an immunosuppressed rabbit model." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103272.

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Uveal melanoma is the most common primary intraocular malignant tumour in adults. Despite improvements in the diagnosis and treatment of the primary tumour, patients continue to have the same mortality rate as several decades ago, reflecting our poor understanding of the mechanisms behind the formation of metastases in this disease. The purpose of this study was therefore to characterize an animal model of uveal melanoma and use this model to study the transcriptional changes that cells undergo from culture to intraocular tumour, to circulation and finally to the formation of a metastatic nodu

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45

Dibra, Harpreet Kaur. "Determination of an interaction between the DNA repair proteins MLH1 and sMBD4 and aspirin regulation of DNA repair gene and protein expression in colorectal cancer." Thesis, University of Wolverhampton, 2010. http://hdl.handle.net/2436/109190.

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The base excision repair protein, MBD4 (also known as MED1) is known to be transcriptionally coupled to a mismatch repair protein MLH1. To date the significance of this coupling has not been elucidated and the significance of MBD4 within the mismatch repair system and apoptotic pathway is still being understood. Recently a novel alternatively spliced form of MBD4 has been identified and termed sMBD4. To date the significance of sMBD4 is unknown. MBD4 and sMBD4 share a common glycosylase domain and this is the domain through which MBD4 is reported to interact with MLH1. It was the aim of this s

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46

Desai, Neil Bipinchandra. "Molecular Characterization of Ductal Carcinoma In Situ: Pilot Studies." Yale University, 2010. http://ymtdl.med.yale.edu/theses/available/etd-03242010-174328/.

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Ductal carcinoma in situ (DCIS); is thought directly to precede invasive breast cancer (IBC). Screening mammography has driven the incidence of this key precursor lesion to >65,000 cases per year. However, little is known about the factors controlling the natural history or risk for recurrence following treatment of a particular patients DCIS. Though the heterogeneity of the disease is well established, no histologic or demographic criteria have been able to stratify DCIS for treatment. We hypothesize that at initial diagnosis there exist biologically distinct subsets of DCIS with associated p

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47

Wise, Ingrid. "Epigenetic modifications in essential hypertension." Thesis, Federation University of Australia, 2018. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/165633.

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Background: Hypertension (HTN) is a complex, multifactorial, quantitative trait under polygenic control that affects more than one billion people globally. Despite advances in our understanding of the pathophysiology of HTN and the implementation of more effective treatment and prevention strategies, HTN remains one of the world’s great public health problems. The accepted inference from genome-wide association studies (GWAS) is that the genetic code lays the foundation for transcriptomic changes and in turn physiological change. On the other side of the coin, environmental factors (smoking, d

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48

Liu, Yanling. "Electric DNA chips for determination of pathogenic microorganisms." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9187.

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49

Rostami, Elham. "Traumatic brain injury in humans and animal models." Doctoral thesis, Stockholm : Reproprint AB, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088.

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50

So, Austin Pierre. "Universal Sequence Tag Array (U-STAR) platform : strategies towards the development of a universal platform for the absolute quantification of gene expression on a global scale." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5580.

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Abstract:

The advent of technologies specifically designed to capture glimpses of gene expression on a systems-wide scale has led to a revolution in our understanding of cellular dynamics, identifying the contributions and interactions of families of genes involved in cell development, dysfunction, and death. Broadly classified into count-based “digital” or signal-based “analogue” approaches, these technologies have permitted “portraits” of the transcriptome to be generated through comparative measurements of gene expression, enabling, for example, the generation of qualitative models of disease. Howeve

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