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Dissertations / Theses on the topic 'Gene control'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Sturm, Richard Alan. "Control mechanisms of higher eukaryotic gene transcription--divergent histone genes /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phs936.pdf.

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2

Curtis, R. K. "Control analysis of gene expression." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598230.

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This thesis describes the development of the application of modular regulation analysis, a subset of metabolic control analysis to microarray data. Microarray experiments measure complex changes in the abundance of many mRNAs under different conditions. Current analysis methods, such as clustering, cannot distinguish between direct and indirect effects on expression, or calculate the relative importance of mRNAs in effecting responses. Modular regulation analysis of microarray data reveals and quantifies which mRNA changes are important for cellular responses. The mRNAs are clustered, then ho

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3

Terry, Catherine. "Genetic control of Interleukin-6 gene." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342452.

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4

Meyer, Kerstin Barbara. "Control of immunoglobin #kappa# gene expression." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359875.

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5

Sornarajah, Renuka. "Chloroplast control of nuclear gene expression." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364277.

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6

Zabron, Abigail Anna. "Plastid control of nuclear gene expression." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621561.

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7

Sullivan, James Andrew. "Plastid control of nuclear gene expression." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624481.

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8

Uhlendorf, Jannis. "Real-time feedback control of gene expression." Phd thesis, Université Paris-Diderot - Paris VII, 2013. http://tel.archives-ouvertes.fr/tel-00850778.

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L'expression génétique est un processus cellulaire fondamental réglé de manière ne. Les promoteurs inducibles perme ent de perturber l'expression génétique en changeant l'expression d'une protéine par rapport à son niveau physiologique de référence. Ce e propriété en fait un outil incontournable pour décrypter le fonctionnement des processus biologiques via la comparaison du comportement de la cellule sous divers niveaux d'induction. Toutefois, une limite actuelle à l'utilisation des promoteurs inducibles provient de la difficulté à appliquer des perturbations précises et dynamiques. Les deux

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9

Aparicio, i. Prat Estel. "Natural antisense transcripts control LEF1 gene expression." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299211.

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Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a promoter present in the first LEF1 intron and undergoes splicing in mesenchymal cells. In epithelial cells, there is no expression of LEF1 NAT. However, in metastable epithelial cells, LEF1 NAT is transcribed and a significant part of it remains unspliced and, contrarily to the spliced NAT, down-regulates the main LEF1 promoter and LEF1 mRNA and protein expression. Moreo

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10

Heinz, Sabine. "Metabolite control of gene expression in cucumber." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302132.

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11

Wilkinson, Ruth Hannah. "Gene Rummy : Keeping Control of Your Hand." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508899.

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12

Aparicio, i. Prat Estel 1986. "Natural antisense transcripts control LEF1 gene expression." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299211.

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Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a promoter present in the first LEF1 intron and undergoes splicing in mesenchymal cells. In epithelial cells, there is no expression of LEF1 NAT. However, in metastable epithelial cells, LEF1 NAT is transcribed and a significant part of it remains unspliced and, contrarily to the spliced NAT, down-regulates the main LEF1 promoter and LEF1 mRNA and protein expression. Moreover, un

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13

Krohn, J. P. "A gene regulatory network model for control." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1416287/.

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The activity of a biological cell is regulated by interactions between genes and proteins. In artificial intelligence, this has led to the creation of developmental gene regulatory network (GRN) models which aim to exploit these mechanisms to algorithmically build complex designs. The emerging field of GRNs for control aims to instead exploit these natural mechanisms and this ability to encode a large variety of behaviours within a single evolvable genetic program for the solution of control problems. This work aims to extend the application domain of GRN models to previously unsolved control

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14

Willer, Elizabeth Jane. "Control of B2 bradykinin receptor gene expression." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286487.

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15

Wu, Chia-Yung. "Control of gene expression by cell size." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57564.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Polyploidy, increased copy number of whole chromosome sets in the genome, is a common cellular state in evolution, development and disease. Polyploidy enlarges cell size and alters gene expression, producing novel phenotypes and functions. Although many polyploid cell

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16

Johnstone, Louise E. "Control of gene expression in neurosecretory neurones." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20592.

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This thesis examines mechanisms of regulation of neuropeptide gene expression <I>in vivo</I> in some neurosecretory hypothalamic neurones of the rat. In particular, the influence of neural pathways, acting via receptors and subsequent regulation of genetic transcription factors was measured and second messenger pathways were directly manipulated and the effects of their mutation on gene expression were measured. The magnocellular neurones of the supraoptic nucleus (SON) are known to be directly (i.e. non-synaptically) osmosensitive. Fos, the protein product of the immediate early gene <I>c-fos

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17

Layyous, Andrea. "Transcriptional control of the human aggrecan gene." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6416.

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Osteoarthritis (OA) is a degenerative joint disease and is the leading cause of physical disability in industrialised nations. Cartilage has received the most attention in the study of OA due to articular chondrocytes acting as potential instigators of disease. These cells are responsible for the anabolic-catabolic balance required for matrix maintenance due to their ability to synthesise the structural components of the extra-cellular matrix along with matrix-degrading proteases. In order to better understand the mechanism by which this balance is shifted in OA, it would be useful to investig

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18

Matsui, Kazuki. "Size Control in Gene and siRNA Delivery." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124555.

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19

Bombail, Vincent. "Transcriptional control of the human CYP3A4 gene." Thesis, University of Surrey, 2003. http://epubs.surrey.ac.uk/843500/.

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CYP3A4 is the most abundant P450 enzyme expressed in the human liver and it is responsible for the metabolism of approximately 50% of all clinically administrated drugs. The CYP3A4 gene is transcriptionally regulated by xenobiotics and previous work has demonstrated the first 300bp of proximal promoter to be the minimal requirement for such activation. Several nuclear receptors (CAR, SXR) have been shown to be involved in the induction of the CYP3A4 gene. The aim of this work was to further delineate the molecular basis of CYP3A4 gene expression. In vitro DNase I footprinting was carried out u

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20

Thorburn, A. M. "Control of vitellogenin gene expression in Xenopus laevis." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355816.

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21

Davidson, Rosemary Karen. "Metalloproteinase gene expression and its control in osteoarthritis." Thesis, University of East Anglia, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502365.

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Osteoarthritis (OA) is the most common arthritic condition. It is a debilitating disease of the joints, characterised by articular cartilage degradation. Effective, disease-modifying drugs are not currently available for the treatment ofOA. Matrix metalloproteinase (MMP) and a disintegrin, a metalloproteinase and a thrombospondin motif (ADAMTS) proteases are capable of degrading all components of the extracellular matrix (ECM). Their activities are normally balanced by tissue inhibitors of metalloproteinases (TIMPs). Together MMPs, ADAMTSs and TIMPs regulate the normal turnover of extracellula

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22

Powley, Ian Robert. "Translational control of gene expression following DNA damage." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478975.

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23

Christodoulou, Stephen. "Control of a heat-shock gene in yeast." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385183.

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24

Dhami, Pawandeep. "The SCL gene and transcriptional control of haematopoiesis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613992.

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25

Krieg, Michael, Alba Diz-Muñoz, Martin Bergert, et al. "Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180853.

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Cell shape and motility are primarily controlled by cellular mechanics. The attachment of the plasma membrane to the underlying actomyosin cortex has been proposed to be important for cellular processes involving membrane deformation. However, little is known about the actual function of membrane-to-cortex attachment (MCA) in cell protrusion formation and migration, in particular in the context of the developing embryo. Here, we use a multidisciplinary approach to study MCA in zebrafish mesoderm and endoderm (mesendoderm) germ layer progenitor cells, which migrate using a combination of differ

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26

Tan, Mehmet. "Induction And Control Of Large-scale Gene Regulatory Networks." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610619/index.pdf.

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Gene regulatory networks model the interactions within the cell and thus it is essential to understand their structure and to develop some control mechanisms that could effectively deal with them. This dissertation tackles these two aspects. To handle the first problem, a new constraint-based modeling algorithm is proposed that can both increase the quality of the output and decrease the computational requirements for learning the structure of gene regulatory networks by integrating multiple biological data types and applying a special method for dense nodes in the network. Constraint-based st

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27

Brend, Timothy. "Transcriptional control of the Hoxb4 gene during mouse development." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397332.

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28

Carr, A. "Control of delta crystallin gene expression during retinal transdifferentiation." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353563.

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29

Johnson, Paul Andrew. "The control of herpes simplex virus late gene transcription." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481097.

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30

Strutt, David Ian. "Identifying the targets of homeotic gene control in Drosophila." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239207.

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31

Topol, Joanne Parker Carl Stevens Parker Carl Stevens. "Transcriptional control of the drosophila segmentation gene fushi tarazu /." Diss., Pasadena, Calif. : California Institute of Technology, 1990. http://resolver.caltech.edu/CaltechETD:etd-08292007-085427.

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32

Luchsinger, Larry L. "Control of myofibroblast gene expression by transcriptional co-regulators." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12493.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Type I collagen overexpression is a major contributor to fibrosis. This thesis investigates the function of two transcriptional co-regulator complexes involved in collagen expression. Interferon γ induces class

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33

Zhu, Yaowei. "Transcriptional control of the pcbAB gene in Penicillium chrysogenum." Thesis, University of Westminster, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296123.

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34

Gherardi, Samuele <1981&gt. "Myc-mediated control of gene transcription in cancer cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2809/.

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The Myc oncoproteins belong to a family of transcription factors composed by Myc, N-Myc and L-Myc. The most studied components of this family are Myc and N-Myc because their expressions are frequently deregulated in a wide range of cancers. These oncoproteins can act both as activators or repressors of gene transcription. As activators, they heterodimerize with Max (Myc associated X-factor) and the heterodimer recognizes and binds a specific sequence elements (E-Box) onto gene promoters recruiting histone acetylase and inducing transcriptional activation. Myc-mediated transcriptional repres

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35

Martin, Patricia E. M. "Control of protein synthesis by the reovirus S4 gene." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/108094/.

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Mammalian reoviruses have been used as a model to study the control of host cell protein synthesis following infection. The reovirus genome is composed of 10 segments of double stranded RNA each of which, with one exception, encodes a single protein. The three serotypes of the virus show marked differences in their effects on host cell protein synthesis following viral infection. Serotypes 2 and 3 give pronounced inhibition and serotype 1 has little effect. Genetic studies using intertypic reassortants have mapped this property to the S4 gene of the virus which encodes the major outer capsid p

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36

Rohlfing, Amy Elizabeth. "Coordinate control of virulence gene expression in Francisella tularensis." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467492.

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Francisella tularensis is a Gram-negative, intracellular pathogen and the causative agent of tularemia. Due to its low infectious dose, ability to cause potentially fatal disease, and ability to be easily aerosolized, several countries have developed F. tularensis as a potential bioweapon. Three proteins, MglA, SspA, and PigR, and the small molecule guanosine tetraphosphate (ppGpp), are transcription factors critical for the virulence of this organism. These regulators function coordinately to positively regulate the expression of genes present on the Francisella pathogenicity island, as well

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37

Lovejoy, Elizabeth A. "RAGE-based strategies for the control of gene expression." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/26699.

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The Cre/loxP site-specific recombinase system evolved within bacteriophage PI as a mechanism to maintain correct unit copy segregation of the prophage within host cells. This thesis reports the application of this system to regulate gene expression in murine cells. To regulate gene expression via RAGE (Recombination Activated Gene Expression) a novel floxed STOP cassette was designed, constructed and tested in murine embryonic fibroblasts (EF) and embryonic stem (ES) cells. When the floxed STOP cassette was used to regulate the expression of the Enhanced Green Fluorescent Protein (EGFP) marker

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38

Thakur, Noopur. "Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5725.

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Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). To elucidate the mechanisms by which the imprinting is maintained in clusters, we have chosen a well characterized cluster at the distal end of mouse chromosome 7. This cluster contains 15 imprinted genes and they have been shown to be regulated by H19 and Kcnq1 ICRs. The mouse H19 ICR, which is shown to have

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39

Lewis, Zachary Austin. "Control of rhythmic output from the circadian clock in Neurospora crassa." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1376.

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Circadian rhythms are visible as daily oscillations in biochemical, physiological, or behavioral processes. These rhythms are produced by an endogenous clock that maintains synchrony with the external environment through responses to external stimuli such as light or temperature. The clock, in turn, coordinates internal processes in a time-dependent fashion. Genetic and molecular analysis of the filamentous fungus Neurospora crassa has demonstrated that the products of the frequency (frq) and white-collar (wc-1 and wc-2) genes interact to form an interlocked feedback loop that lies at the hear

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40

Garriga-Canut, Mireia. "Control of neuron specific gene expression : transcriptional regulation of the Mâ†1 muscarinic acetylcholine receptor gene." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367599.

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41

David, John M. "The control of apolipoprotein C-I gene expression during adipocyte differentiation." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 4.92 Mb., p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1435920.

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42

Matthews, Randolph Pretlow. "Second messenger-mediated kinases and the control of gene expression /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6286.

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43

Goldman, Jacki P. "Regulated accessibility of variable region genes may control developmentally ordered T cell receptor [gamma] gene rearrangement." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32626.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.<br>On t.p., "[gamma] appears as the lower case Greek letter.<br>Includes bibliographical references (leaves 155-172).<br>by Jacki P. Goldman.<br>Ph.D.

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44

Behnke, Michael Sean. "Studies of gene expression control in the apicomplexan parasite Toxoplasma gondii." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/behnke/BehnkeM0808.pdf.

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Our understanding of global gene expression patterns and control of both developmental and strain specific aspects of Toxoplasma gondii has broadened in the past few years. A global approach was initially undertaken to construct the "transcriptome" for the Toxoplasma intermediate life cycle using serial-analysis-of-gene expression (SAGE). From this analysis, we confirmed the increased expression of known as well as novel mRNAs associated with the tachyzoite-to-bradyzoite transition. Accumulation of bradyzoite specific mRNAs in the bradyzoite SAGE libraries raises the possibility that transcrip

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45

Canatella, Paul James. "Control and optimization of electroporation-mediated drug and gene delivery." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/11774.

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46

Miller, Nichol L. G. "Transcriptional control of the gonadotropin-releasing hormone gene in development." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3296836.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 113-126).

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47

Brennan-Benson, Paul. "Hormonal control of gene expression in mouse mammary epithelial cells." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260206.

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48

Noble, Karen Elizabeth. "Monocyte endothelium interactions and the control of inflammatory gene expression." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312915.

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49

Chacko, Alexander D. "Post-transcriptional control of gluconeogenic gene expression in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301079.

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This thesis examines the post-transcriptional regulation of the gluconeogenic mRNAs <I>PCK1</I> and <I>FBP1</I> in <I>Saccharomyces cerevisiae</I>. By construction of a set of chimaeric <I>PCK1-PGK1</I> reporter genes, it was possible to show that sequences from the 5' end of the <I>PCK1</I> mRNA were capable of conferring post-transcriptional glucose regulation on the reporter. These regions were presumably the ultimate target of the glucose signal on the wild-type <I>PCK1</I> mRNA. Sequences from the 5' end of the <I>SDH2</I> mRNA had previously been shown to be required for the rapid degrad

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50

Brown, Justin Travis. "MRNA degradation in the control of gene expression in yeast." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3024999.

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