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Dissertations / Theses on the topic 'Gene expression and cDNA microarray'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Zhao, Hongya. "Statistical analysis of gene expression data in cDNA microarray experiments." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/657.

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Kan, Takatsugu. "Gene expression profiling in human esophageal cancers using cDNA microarray." Kyoto University, 2003. http://hdl.handle.net/2433/148738.

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Wu, Meng. "Data mining cDNA microarray experiment with a GEE approach /." Electronic version (PDF), 2004. http://dl.uncw.edu/etd/2004/wum/mengwu.pdf.

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4

Howell, Brandon George. "Gene expression profiling of UV-induced skin cancer using cDNA microarray technology." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63108.pdf.

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Van, Laar Ryan. "Optimisation of cDNA microarray tumour profiling and molecular analysis of epithelial ovarian cancer /." Connect to thesis, 2005. http://eprints.unimelb.edu.au/archive/00002764.

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6

Jouenne, Vincent Y. "Critical Issues in the Processing of cDNA Microarray Images." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/33960.

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Microarray technology enables simultaneous gene expression level monitoring for thousands of genes. While this technology has now been recognized as a powerful and cost-effective tool for large-scale analysis, the many systematic sources of experimental variations introduce inherent errors in the extracted data. Data is gathered by processing scanned images of microarray slides. Therefore robust image processing is particularly important and has a large impact on downstream analysis. The processing of the scanned images can be subdivided in three phases: gridding, segmentation and data extract

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Mantri, Nitin Laxminarayan, and nitin_mantri@rediffmail com. "Gene expression profiling of chickpea responses to drought, cold and high-salinity using cDNA microarray." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080509.160714.

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Cultivated chickpea (Cicer arietinum) has a narrow genetic base making it difficult for breeders to produce new elite cultivars with durable resistance to major biotic and abiotic stresses. As an alternative to genome mapping, microarrays have recently been applied in crop species to identify and assess the function of putative genes thought to be involved in plant abiotic stress and defence responses. In the present study, a cDNA microarray approach was taken in order to determine if the transcription of genes, from a set of previously identified putative stress-responsive genes from chickpea

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Yang, Xiao. "Optimal Design of Single Factor cDNA Microarray experiments and Mixed Models for Gene Expression Data." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/26379.

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Microarray experiments are used to perform gene expression profiling on a large scale. E- and A-optimality of mixed designs was established for experiments with up to 26 different varieties and with the restriction that the number of arrays available is equal to the number of varieties. Because the IBD setting only allows for a single blocking factor (arrays), the search for optimal designs was extended to the Row-Column Design (RCD) setting with blocking factors dye (row) and array (column). Relative efficiencies of these designs were further compared under analysis of variance (ANOVA) models

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9

Stolf, Beatriz Simonsen. "Identificação de marcadores moleculares para o câncer de tireóide por cDNA microarrays." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-21072008-101124/.

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Doenças tireoideanas são bastante comuns, sendo sua maioria benigna. A relação entre os diversos tipos de doenças tireoideanas, bem como seus aspectos moleculares, são pouco conhecidos. O bócio (hiperplasia), por exemplo, é descrito por alguns como relacionado com carcinoma (tumor maligno) papilífero, enquanto que outros afirmam não haver relação causal entre as duas doenças. A questão mais desafiante, porém, refere-se à distinção entre adenoma (tumor benigno) e carcinoma folicular, que atualmente é feita apenas após à cirurgia, não permitindo tratamento diferenciado para os dois tipos de tumo

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Camilo, Cesar Moisés. "Regulação da expressão gênica por oxigênio no fungo aquático Blastocladiella emersonii." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-28042010-082547/.

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Neste trabalho realizamos a análise das variações na expressão gênica global do fungo aquático Blastocladiella emersonii submetido ao estresse de carência de oxigênio (hipóxia), utilizando a técnica de microarranjos de cDNA em lâminas contendo 3773 genes distintos. Nos experimentos de hipóxia gradual (diminuição gradual da concentração de oxigênio dissolvido, seguido de reoxigenação) e hipóxia direta (diminuição direta da concentração de oxigênio dissolvido, seguido de reoxigenação) observamos que 650 genes foram diferencialmente expressos em pelo menos uma das condições de estresse e que 534

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Ferreira, Maidy Rehder Wimmers. "Avaliação do perfil de expressão gênica em grande escala de células indiferenciadas da polpa e de células odontoblásticas utilizando cDNA microarray." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-09062011-094759/.

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O extraordinário potencial regenerativo do complexo dentino-pulpar enfatiza a importância da caracterização dos processos celulares e moleculares envolvidos na regeneração dentinária. O avanço da pesquisa com células-tronco desencadeou um grande interesse de cultivá-las na presença de sinais de indução odontogênica. O objetivo do presente trabalho foi avaliar comparativamente células indiferenciadas da polpa (OD-21) e odontoblásticas (MDPC-23) através da avaliação do estímulo celular e do perfil de expressão gênica. As células OD-21 e MDPC-23 foram cultivadas em garrafas de cultura até a subco

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12

Au, Siu Kie. "Gene expression profiling of non-small cell lung cancer using cDNA microarrays /." access full-text access abstract and table of contents, 2009. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?phd-bch-b23749490f.pdf.

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Thesis (Ph.D.)--City University of Hong Kong, 2009.<br>"Submitted to Department of Biology and Chemistry in partial fulfillment of the requirements for the degree of Doctor of Philosophy." Includes bibliographical references (leaves 133-147)

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Filippi, Renée Zon. "Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-26012012-100515/.

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O hepatoblastoma é uma neoplasia embrionária hepática que ocorre na faixa pediátrica, rara, sendo bastante heterogênea devido aos seus diferentes componentes epiteliais e mesenquimais. Pouco ainda se sabe a respeito de sua patogênese. Utilizando um microscópio de captura a laser foram dissecadas áreas de componente epitelial do hepatoblastoma e áreas de tecido hepático adjacente não acometido. Destas amostras obtidas de pacientes não submetidos ao tratamento prévio, foram extraídos RNA e confeccionados cDNA microarrays, para análise comparativa da expressão gênica, seguida de validação por mét

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Silva, Aderbal Ruy Teodoro da. "Avaliação da expressão gênica na doença de Alzheimer através da técnica de cDNA microarray em amostras de cérebro postmortem humano." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-25032009-102640/.

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A doença de Alzheimer (DA) recebeu intenso estudo durante as décadas passadas. Apesar de ter acontecido avanços significantes no esclarecimento da fisiopatologia da DA, o diagnóstico da doença é ainda imperfeito. Por um lado, cerca de 20% dos pacientes diagnosticados com DA provável, na autópsia, não apresenta alterações patológicas da doença. Por outro lado, por que alguns indivíduos têm alto grau da patologia da DA, mas não tem demência, é uma questão aberta. Para se obter uma melhor compreensão dos achados patológicos e os sinais clínicos na DA, foi buscado um transcriptoma diferencial, atr

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Alcalde, Felipe Santiago Chambergo. "Elucidação do destino metabólico de glicose no fungo filamentoso Trichoderma reesei por análise EST (Expressed Sequence Tags) e "microarrays" de cDNA." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11022003-130558/.

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Apesar do intenso interesse na regulação metabólica e evolução das vias produtoras de ATP, o porquê de a maioria dos microorganismos multicelulares metabolizarem glicose através de respiração, ao invés da fermentação, ainda permanece sem resposta. Um desses microorganismos é o fungo celulolítico Trichoderma reesei (Hypocrea jecorina. Usando análise EST e microarrays de cDNA, foi estabelecido, em T. reesei, que a expressão dos genes que codificam as enzimas do ciclo de TCA é programada de tal modo a favorecer a oxidação de piruvato pelo ciclo de TCA, ao invés de sua redução a etanol, através

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Barnhart, Kirstin Faye. "In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10." Texas A&M University, 2004. http://hdl.handle.net/1969.1/2671.

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Natural diseases caused by keratin mutations are rare and have only been reported in humans. We have recently identified a heritable skin disorder in Norfolk terriers caused by a mutation in KRT10. Affected dogs have a tendency to form shallow erosions or blisters following mild trauma, which is first noted after the birthing process. As the dogs age, they display generalized hyperpigmentation and scaling that is most severe in the axillary and inguinal regions. The main histologic and ultrastructural features include: marked hyperkeratosis, epidermal hyperplasia, prominent vacuolation of the

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Tomascik-Cheeseman, Lisa Marie. "Gene expression profiling in prepubertal and adult male mice using cDNA and oligonucleotide microarrays." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2813.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains xiii, 180 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 138-151).

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Lepikson-Neto, Jorge 1980. "Analise da expressão genica em diferentes especies de eucalipto utilizando a tecnologia de microarranjos de cDNA." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314279.

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Orientador: Gonçalo Amarante Guimães Pereira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-12T09:23:56Z (GMT). No. of bitstreams: 1 Lepikson-Neto_Jorge_M.pdf: 1765356 bytes, checksum: c73289c953d58c6b221c2e0927805499 (MD5) Previous issue date: 2008<br>Resumo: Com o intuito de obter informações relevantes para o melhoramento genético do eucalipto para a produção de biomassa, o presente trabalho buscou comparar a expressão dos genes relacionados com a formação e desenvolvimento da madeira em quatro diferentes espécie

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McWilliam, Iain Stuart. "Development of microarray techniques for the study of gene expression in the European eel (Anguilla anguilla) during silvering and migration to seawater." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/502.

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Delcolli, Maria Isabel Mesquita Vendramini. "Avaliação genética e imunológica de famílias com deficiências nos componentes C3 ou Fator I do Sistema Complemento e a influência dessas deficiências na expressão gênica de fibroblastos de pele humana." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18092012-112932/.

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Avaliamos as causas moleculares da deficiência de C3 ou de FI em 07 pacientes, chegando a caracterizar a causa molecular em cinco deles. As mutações encontradas em cada um dos pacientes foram: C3def3 - C364G troca Arg102Gly; G2481C (Val807); A4956G (Val1632); FIdef2 - G693A, troca Gly162Asp; FIdef3 e -4 - C767T, troca Arg187Stop; FIdef6 e -7 - Inserção 1382<font face=\"Symbol\">DAT, códon de parada prematura 13 bases a montante. Além disso, analisamos se a ausência dessas proteínas levava a alterações na expressão gênica em fibroblastos de pele de pacientes deficientes de C3 ou de FI em relaçã

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21

Bonaccorsi, Eric D\'Alessandro. "Regulação da expressão gênica por oxigênio em microrganismos eucariotos: análises de ESTs (Expressed Sequence Tags) e microrrays de cDNA de Trichoderma reesei." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-04052018-110230/.

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Glicose e oxigênio são moléculas essenciais para a maioria dos organismos vivos. Além de sua importância nos processos de produção de energia - glicose como fonte de carbono e energia e oxigênio como aceptor dos elétrons doados por NADH e FADH2 - estes dois compostos funcionam como efetuadores, modulando vários processos metabólicos e fisiológicos nas células. Visto que a mitocôndria é um dos alvos afetados pelas disponibilidades destas duas moléculas, nós isolamos e seqüenciamos o genoma mitocondrial de Trichoderma reesei, um fungo multicelular empregado neste trabalho como sistema modelo. Fo

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22

Asprino, Paula Fontes. "Análise de expressão gênica por microarrays de cDNA em linhagens de células adrenais tumorigênicas tratadas com FGF2 e ACTH." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-05092006-161414/.

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Uma premissa da Biologia Molecular atual estabelece a ativação de programas de transcrição voltados a processos biológicos específicos. Neste trabalho o objetivo é descrever genes regulados que, uma vez agrupados, são capazes de indicar os programas disparados na linhagem corticoadrenal murina Y1 quando tratada com o fator de crescimento de fibroblasto 2 (FGF2) ou pelo hormônio adrenocorticotrópico (ACTH). O papel de ACTH em células Y1 ainda não está bem estabelecido quanto ao seu potencial mitogênico, uma vez que este hormônio é capaz de agir por diferentes vias de sinalização, apresentando u

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23

Vasanthavada, Keshav. "Generation of cDNA chips from the black widow spider, latrodectus hesperus, for gene discovery and expression profiling using microarray technology, and molecular characterization of a novel silk glue protein." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/624.

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eDNA microarray technology has generated a tremendous amount of interest among biologists because of its promise to monitor the entire genome on a single chip, thus enabling researchers to have a better picture of the interaction among thousands of genes simultaneously. In the current study, this technology was used to print over 3,000 unknown genes from various silk glands of the black widow spider to profile their expression patterns and to identify novel candidates. Spiders are remarkable creatures because of their ability to make different silks, each with a specific function. Some of thes

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Yang, Yi. "Statistical analysis of cDNA microarrays a systematic approach to identify MTF-1 mediated gene expression profile in response to cadmium /." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1054209876.

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Yan, Yi. "Statistical Analysis Of cDNA Microarrays – A Systematic Approach to Identify MTF-1 Mediated Gene Expression Profile in Response to Cadmium." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054209876.

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Tahira, Ana Carolina. "Análise da expressão de RNAs não codificadores longos em adenocarcinoma de pâncreas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-10062013-145054/.

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RNAs não codificadores longos (lncRNAs) compõem uma fração significativa do transcriptoma. Alterações na expressão de lncRNAs já foram observadas em vários cânceres humanos, mas ainda não foram exploradas no adenocarcinoma pancreático ductal (PDAC), uma doença devastadora e agressiva para a qual faltam métodos para diagnóstico precoce e tratamentos efetivos. Utilizando uma plataforma de microarranjo de cDNA com sondas para 984 lncRNAs e 2371 mRNAs, o presente estudo identificou conjuntos de lncRNAs expressos em 38 amostras clínicas pancreáticas. O enriquecimento de (i) elementos regulatórios a

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Peralta, Angela. "Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation." Scholarly Commons, 2010. https://scholarlycommons.pacific.edu/uop_etds/755.

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While development in flies is well understood, pattem formation and the evolution thereof in arachnids have yet to be clarified. Flies and other metazoans primarily use two families of genes called Hox genes and Pax genes to regulate embryogenesis. Because of the high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem black widow spider, Latrodectus hesperus, an embryonic eDNA library and a fixation protocol were developed for L. hesperus embryos. The generation of these tools will

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Assersohn, Laura Claire. "Assessment of protein molecular markers as predictors of response to primary medical treatment in breast cancer and evaluation of gene expression profiles of fine needle aspirates using cDNA microarray technology." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395026.

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Fitzpatrick, J. M. "The development and use of tachyzoite cDNA microarrays to profile gene expression in two distinctly virulent strains of the Apicomplexan pathogen Toxoplasma gondii." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599060.

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A cDNA microarray was developed with 12 288 elements, consisting mainly of <i>T. gondii</i> tachyzoite (acute infection stage) expressed sequence tags (ESTs). Prior to expression analysis, the fabricated microarray was characterized by utilizing redundancy within the EST set. The redundancy facilitated the evaluation of cDNA hybridization specificity amongst sequences of both low and high similarity. Employing a representative member of a large related gene family as a specific target, optimized experimental hybridization conditions and data filtering methods were developed to investigate the

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Colombo, Jucimara [UNESP]. "Identificação de genes diferencialmente expressos em câncer de laringe." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/102742.

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Made available in DSpace on 2014-06-11T19:32:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-07-24Bitstream added on 2014-06-13T20:43:03Z : No. of bitstreams: 1 colombo_j_dr_sjrp.pdf: 949474 bytes, checksum: 856a4b47ea1a9aa6adebae3e2e97b6a0 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Os tumores de cabeça e pescoço ocupam, mundialmente, a quinta posição na lista das neoplasias mais freqüentes. O tipo histológico predominante é o carcinoma de células escamosas, que acomete a cavidade oral, a orofaringe, a hipofaringe e a laringe. O tumor de laringe é um

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Haye, Alexandre. "Modélisation de l'évolution temporelle de l'expression des gènes sur la base de données de puces à ADN: application à la drosophile." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209904.

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Cette thèse de doctorat s’inscrit dans le développement et l’utilisation de méthodes mathématiques et informatiques qui exploitent les données temporelles d’expression des gènes issues de puces à ADN afin de rationaliser et de modéliser les réseaux de régulation génique. Dans cette optique, nous nous sommes principalement intéressés aux données d’expression des gènes de la drosophile (Drosophila melanogaster) pendant son développement, du stade embryonnaire au stade adulte. Nous avons également étudié des données concernant le développement d’autres eucaryotes supérieurs, la réponse d’une bact

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Macedo, Claudia. "O papel modulador do gene Aire (autoimmune regulator) sobre redes de expressão gênica em células tímicas epiteliais medulares." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13042009-144302/.

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A expressão de antígenos restritos a tecidos (TRAs do inglês tissue restricted antigens) no timo pelas células epiteliais medulares (mTECs de medullary thymic epithelial cells) é essencial para a tolerância central das células T. Devido à sua heterogeneidade em termos de representação de autoantígenos, esse fenômeno foi denominado como expressão gênica promíscua (PGE de promiscuous gene expression), no qual o gene Aire (de autoimmune regulator) desempenha um papel como principal regulador transcricional positivo sobre um grande conjunto de TRAs dependentes de Aire. A proteína Aire tem a capaci

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Soneji, Sharnit. "Statistical Analysis of cDNA Microarray Directed by Gene Function." Thesis, Birkbeck (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487759.

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Microarrays allow the expression level of thousands of genes to be measured simultaneously. This study will address analytical issues predominantly concerned with eDNA arrays. These include normalisation and data preprocessing, leading to an assessment of cluster analysis and the integration of database information to elucidate functional classes of biological relevance. This is then extended further to classify genes of unknown function using Markov Random Fields. I Modelling of uneven surface trends were considered in a new 2D-normalisation method which outperformed the popular loess method

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Van, Eck Leon. "Aphid-induced transcriptional regulation in near-isogenic wheat." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-07152007-195017.

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Szeto, Lap Keung. "Clustering analysis of microarray gene expression data /." access full-text access abstract and table of contents, 2005. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?mphil-it-b19885817a.pdf.

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Thesis (M.Phil.)--City University of Hong Kong, 2005.<br>"Submitted to Department of Computer Engineering and Information Technology in partial fulfillment of the requirements for the degree of Master of Philosophy" Includes bibliographical references (leaves 70-79)

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Botella, Pérez Cristina. "Multivariate classification of gene expression microarray data." Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/9046.

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L'expressiódels gens obtinguts de l'anàliside microarrays s'utilitza en molts casos, per classificar les cèllules. En aquestatesi, unaversióprobabilística del mètodeDiscriminant Partial Least Squares (p-DPLS)s'utilitza per classificar les mostres de les expressions delsseus gens. p-DPLS esbasa en la regla de Bayes de la probabilitat a posteriori. Aquestsclassificadorssónforaçats a classficarsempre.Per superaraquestalimitaciós'haimplementatl'opció de rebuig.Aquestaopciópermetrebutjarlesmostresamb alt riscd'errors de classificació (és a dir, mostresambigüesi outliers).Aquestaopció de rebuigcombi

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Eijssen, Lars Maria Theo. "Analysis of microarray gene expression data sets." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=6830.

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Molloy, Timothy John St George Clinical School UNSW. "Gene expression in healing tendon." Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/23939.

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Tendon injury is painful and often debilitating, and is a one of the most prevalent soft tissue injuries encountered in the clinic. While common, the underlying molecular and genetic processes of tendon damage and repair remain poorly understood. The work described herein used genome-wide expression analyses to investigate tendon injury and healing from three perspectives. The first identified novel gene expression in tendon fibroblasts following their stimulation with nitric oxide (NO). Of particular relevance to tendon healing was the observation that stimulated fibroblasts express a number

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Laurell, Cecilia. "Microarray Based Gene Expression Analysis in Cancer Research." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4244.

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Mohammed, Suhaib. "Consensus network inference of microarray gene expression data." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/24185.

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Genetic and protein interactions are essential to regulate cellular machinery. Their identification has become an important aim of systems biology research. In recent years, a variety of computational network inference algorithms have been employed to reconstruct gene regulatory networks from post-genomic data. However, precisely predicting these regulatory networks remains a challenge. We began our study by assessing the ability of various network inference algorithms to accurately predict gene regulatory interactions using benchmark simulated datasets. It was observed from our analysis that

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Smith, E. P. "Analysis of herpesvirus saimiri gene expression by cDNA cloning." Thesis, University College London (University of London), 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371058.

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Morimoto, Shoko. "Global Gene Expression in Haloferax volcanii." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306873403.

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Jiang, Ying, and 蔣穎. "Studies of gene regulation using microarray data." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29976388.

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Khondoker, Md Mizanur Rahman. "Statistical methods for pre-processing microarray gene expression data." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12367.

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A novel method is developed for combining multiple laser scans of microarrays to correct for “signal saturation” and “signal deterioration” effects in the gene expression measurement. A multivariate nonlinear functional regression model with Cauchy distributed errors having additive plus multiplicative scale is proposed as a model for combining multiple scan data. The model has been found to flexibly describe the nonlinear relationship in multiple scan data. The heavy tailed Cauchy distribution with additive plus multiplicative scale provides a basis for objective and robust estimation of gene

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Aggelis, Alexandros. "Gene expression in ripening melon (Cucumis melo L.)." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319646.

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O'Mullan, Catherine Anne. "Identification of isocitrate lyase cDNA clones in Chlorella." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356956.

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Marconi, Daniela <1979&gt. "New approaches to open problems in gene expression microarray data." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/842/.

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In the past decade, the advent of efficient genome sequencing tools and high-throughput experimental biotechnology has lead to enormous progress in the life science. Among the most important innovations is the microarray tecnology. It allows to quantify the expression for thousands of genes simultaneously by measurin the hybridization from a tissue of interest to probes on a small glass or plastic slide. The characteristics of these data include a fair amount of random noise, a predictor dimension in the thousand, and a sample noise in the dozens. One of the most exciting areas to which

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Zhu, Yitan. "Learning Statistical and Geometric Models from Microarray Gene Expression Data." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28924.

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In this dissertation, we propose and develop innovative data modeling and analysis methods for extracting meaningful and specific information about disease mechanisms from microarray gene expression data. To provide a high-level overview of gene expression data for easy and insightful understanding of data structure, we propose a novel statistical data clustering and visualization algorithm that is comprehensively effective for multiple clustering tasks and that overcomes some major limitations of existing clustering methods. The proposed clustering and visualization algorithm performs progre

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Zhang, Guilin. "Clustering Algorithms for Time Series Gene Expression in Microarray Data." Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc177269/.

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Clustering techniques are important for gene expression data analysis. However, efficient computational algorithms for clustering time-series data are still lacking. This work documents two improvements on an existing profile-based greedy algorithm for short time-series data; the first one is implementation of a scaling method on the pre-processing of the raw data to handle some extreme cases; the second improvement is modifying the strategy to generate better clusters. Simulation data and real microarray data were used to evaluate these improvements; this approach could efficiently generate m

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沈艾品. "Analysis the Gene Expression Profile during Epidermis Differentiation By cDNA Microarray Assay." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/59743527067371173455.

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碩士<br>國防醫學院<br>生物及解剖學研究所<br>91<br>Cellular differentiation is a process in which a group of specific gene is programmatically induced. In order to find out genes that participate in epithelium differentiation, we used cDNA microarray technique to analyze the difference of gene expression between keratinized and non- keratinized C9 cells, and recheck the data by RT-PCR. The microarrray data show that the pattern of gene expression in C9 cell differentiation is consistent with previously studies of epidermal differentiation. Hence, C9 cell is a potential model for studying epidermal differentiat

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