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Dissertations / Theses on the topic 'Gene expression'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Knight, Deborah. "Novel schizophrenia risk genes and gene expression." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/47378/.

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ZNF804A was (at the time this work started) one of only a few robustly implicated schizophrenia susceptibility genes, due to replicated genome-wide significant evidence for association between a polymorphism in the gene and schizophrenia. Determining the function of the ZNF804A protein, which is currently unknown, may provide a way of elucidating the pathophysiology of this relatively common, complex disorder. Based on the hypothesis that the ZNF804A protein regulates gene expression or splicing, the aim of this thesis was to identify genes that exhibit altered expression or splicing in brain

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2

Preuten, Tobias. "Organellar gene expression." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16142.

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Zusätzlich zu der eubakteriellen RNA-Polymerase (RNAP) der Plastiden sind im Zellkern von Arabidopsis thaliana drei weitere, phagentypische RNAP kodiert, die jeweils aus nur einer Einheit aufgebaut sind. Die Enzyme RpoTp und RpoTm werden in die Plastiden, bzw. die Mitochondrien transportiert, während RpoTmp in beiden Organellen zu finden ist. Um die Lichtabhängigkeit der RpoT-Gene zu untersuchen, wurde die lichtinduzierte Akkumulation ihrer Transkripte in 7-Tage alten Keimlingen, sowie 3- bzw. 9-Wochen alten Rosettenblättern mittels quantitativer real-time PCR ermittelt. Die entwicklungsabhäng

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3

Jia, Yizhen, and 贾亦真. "Bioinformatics study of the lineage and tissue specificity of genes and gene expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45540652.

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4

Berggren, Bremdal Karin. "Evolution of MHC Genes and MHC Gene Expression." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122011.

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Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. MHC genes encode antigen-presenting molecules in the adaptive immune system, which protects the host from infectious diseases. However, MHC molecules may also present self-peptides and for most autoimmune diseases there is a genetic factor associated with the MHC. MHC genes have been used to learn

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5

Bashiardes, Evy. "Gene polymorphisms, gene expression and atherosclerotic plaques." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420882.

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6

Smith, Erin N. "Gene-environment interaction in yeast gene expression /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5025.

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7

Lemons, Derek Scott. "Gene expression and evolution." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3397172.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed March 23, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 98-111).

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8

Humphries, Clare Ruth. "Gene expression in schizophrenia." Thesis, Imperial College London, 1997. http://hdl.handle.net/10044/1/7770.

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9

Fischer, Heléne. "Gene expression in carcinogenesis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4961-1/.

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10

Hornan, Daniel Mark. "Human macular gene expression." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444745/.

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The human macula is essential for precise vision. It contains many more cone photoreceptors than the peripheral retina, especially in the fovea. Cones are known to express specific opsins and other proteins that form part of the phototransduction cascade. However, relatively little is known about retinal macular gene expression compared with the rod-rich peripheral retina. I obtained human donor eyes and used foveo-macular and macular punches and sections of peripheral retina to study differential gene expression. I combined multiple microarray experiments with quantitative PCR, statistical, a

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11

Tebbutt, Scott James. "Pollen-specific gene expression." Thesis, University of East Anglia, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334705.

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12

Al-Nbaheen, May Salem. "Liver specific gene expression." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760790.

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13

Herbert, John Matthew Jeff. "Endothelial cell gene expression." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3803/.

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Tumour angiogenesis is a vital process in the pathology of tumour development and metastasis. Targeting markers of tumour endothelium provide a means of targeted destruction of a tumours oxygen and nutrient supply via destruction of tumour vasculature, which in turn ultimately leads to beneficial consequences to patients. Although current anti-angiogenic and vascular targeting strategies help patients, more potently in combination with chemo therapy, there is still a need for more tumour endothelial marker discoveries as current treatments have cardiovascular and other side effects. For the fi

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14

Li, Yan 1978 July 15. "Gene expression array simulator." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/87263.

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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 2002.<br>"May 10, 2002.<br>Includes bibliographical references (leaf 141).<br>by Yan Li.<br>M.Eng.

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15

Johansson, Karin. "Analysis of immunoglobulin gene expression focus on Oct2 /." Lund : Dept. of Cell and Molecular Biology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39776663.html.

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16

Gould, Barbara. "The genomics of labour : global gene expression profiling and oxytocin receptor gene expression." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84251.

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Premature labour and subsequent premature birth is a leading cause of neonatal morbidity and mortality. We studied marine labour at term and preterm with models of intrauterine infection and ovariectomy using Affymetrix microarray U74Av2 (containing 12,488 probe sets) and real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) to identify novel candidate genes involved in normal and preterm labour. Strict statistical analysis revealed 320, 188, and 74 genes to be significantly induced or suppressed during normal, infection-induced, and ovariectomy-induced labour,

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17

Herrig, Danielle Kay. "Evaluating gene flow, gene expression divergence, and hybrid expression in Drosophila sister species." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2222.

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A primary goal of evolutionary biology is to elucidate the factors necessary for a single interbreeding species to become two independent species. Observations and data collected and recorded since the 6th century B.C. have added to our comprehension of the “the origin of species—that mystery of mysteries” (DARWIN 1859). To continue to add to our knowledge of how speciation occurs and how species interact, it is crucial to determine 1) how different categories of genes evolve as species diverge, 2) what happens to hybrids of two species, and 3) if genetic exchange is allowed between species, w

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18

Nascimento, Helvia. "Caracterização da expressão genica de celulas tumorais de pacientes com adenocarcinoma esporadico do colon." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310956.

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Orientador: Carmen Silvia Passos Lima, Fernando Ferreira Costa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T11:53:50Z (GMT). No. of bitstreams: 1 Nascimento_Helvia_D.pdf: 1845231 bytes, checksum: 16f227072d706aacb01f06165bd8a553 (MD5) Previous issue date: 2007<br>Resumo: Os mecanismos moleculares envolvidos na origem do adenocarcinoma de cólon esporádico (ACE) ainda não estão completamente elucidados. Recentemente, o método da análise seriada da expressão gênica (SAGE) foi descrito como eficaz para identifica

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19

McGillivray, Shauna Marie. "Regulation of gonadotrope gene expression /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208634.

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20

Marciniak, Jennifer Yuko. "Variability in eukaryotic gene expression /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208639.

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21

Ma, Pinchao. "Gene expression and splicing efficiency." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27801.

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Most eukaryotic protein-coding genes are split into exons and introns, and introns need to be spliced for the production of mature mRNA by pre-mRNA splicing. Pre-mRNA splicing is very important for eukaryotic gene expression, because it is not only a key step in producing mature mRNA, but can also affect transcription and translation. The purpose of this study is to investigate the relationship between gene expression and splicing efficiency since the relationship has not been studied systematically from a bioinformatic approach. In this thesis research, we focus on the question of how gene ex

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22

Molloy, Timothy John St George Clinical School UNSW. "Gene expression in healing tendon." Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/23939.

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Tendon injury is painful and often debilitating, and is a one of the most prevalent soft tissue injuries encountered in the clinic. While common, the underlying molecular and genetic processes of tendon damage and repair remain poorly understood. The work described herein used genome-wide expression analyses to investigate tendon injury and healing from three perspectives. The first identified novel gene expression in tendon fibroblasts following their stimulation with nitric oxide (NO). Of particular relevance to tendon healing was the observation that stimulated fibroblasts express a number

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23

Palm, Kaia. "Regulation of neuronal gene expression /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980612palm.

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24

Fritz, Georg. "Strategies of bacterial gene expression." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-155355.

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25

Romanuik, Tammy Lee. "Gene expression in prostate cancer." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5313.

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Development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using Long Serial Analysis of Gene Expression (L0ngSAGE) libraries. We identified 35 genes with novel associations to androgen signalling and validated 24 of these genes using quantitative real time-polymerase chain reaction (qRT-PCR). These genes were: ARL6IF5, BL VRB, C]9orf48, C]orfJ22, C6orf66, CAMK2NJ, CCNI, DERA, ERRFI], GLUL, GOLFH3, HMJ3, H

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26

Khan, Mahmood Ali 1962. "Peroxidoxin gene expression in Leishmania." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33792.

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Leishmania protozoans are the etiologic agents of the disease leishmaniasis. The parasite exists in two morphological forms: promastigote and amastigote. Promastigotes are found in the gut of the sandfly vector while amastigotes reside inside the vertebrate macrophage. Leishmania, an obligate intracellular parasite, resists toxic reactive oxygen species (ROS) from both endogenous and exogenous sources. Like other protozoa, Leishmania lacks some of the antioxidant defence enzymes such as catalase and glutathione peroxidase (Gpx) that are usually found in aerobic cells. Instead they possess the

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27

Mason, J. O. "Regulation of immunoglobulin gene expression." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384506.

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28

Naik, Sandhia. "Nutrition and intestinal gene expression." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406381.

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29

Tam, Wai Keung. "Cytokine gene expression in glomerulonephritis." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363081.

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30

Al-Lawati, Sabah Ali Redha. "Differential gene expression in schizophrenia." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420028.

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31

Ebert, Benjamin L. "Oxygen regulation of gene expression." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296895.

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32

Muszynska, Dorota. "Gene expression profiling in Keratoconus." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602693.

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Keratoconus (MIM#148300), a common bilateral, progressive corneal thinning disorder, is the leading indication for corneal transplantation in the developed world. Keratoconus usually arises in the teenage years and presents a significant health burden in work-age adults. Despite the visual and social impact of keratoconus, our lack of understanding of the molecular pathology of keratoconus is a major obstacle to the development of new therapeutic approaches. This study represents the first reported application of massively parallel sequencing of mRNA (RNA-Seq) to perform whole genome transcrip

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33

Ng, W. C. "Studies on vitellogenin gene expression." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484402.

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34

Curtis, R. K. "Control analysis of gene expression." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598230.

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This thesis describes the development of the application of modular regulation analysis, a subset of metabolic control analysis to microarray data. Microarray experiments measure complex changes in the abundance of many mRNAs under different conditions. Current analysis methods, such as clustering, cannot distinguish between direct and indirect effects on expression, or calculate the relative importance of mRNAs in effecting responses. Modular regulation analysis of microarray data reveals and quantifies which mRNA changes are important for cellular responses. The mRNAs are clustered, then ho

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35

Vijayan, Vikram. "Circadian Gene Expression in Cyanobacteria." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10665.

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Cyanobacteria are photosynthetic prokaryotes that live in aquatic environments. The cyanobacterium Synechococcus elongatus PCC 7942, (hereafter S. elongatus) coordinates its day and night behaviors via a circadian clock. The clock is entrained by light/dark cycles but continues to run in constant light conditions. The core circadian clock in S. elongatus is encoded by post-translational modifications of three Kai proteins, but the extent and mechanism of circadian gene expression are unknown. We provide the first unbiased characterization of circadian gene expression in S. elongatus, demonstra

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36

Allan, G. "Gene expression during keratinocyte differentiation." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233424.

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37

MacLeod, Ronald. "Gene expression in human neutrophils." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317206.

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38

Rennie, Sarah. "Regulatory complexity in gene expression." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29503.

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The regulation of gene expression is the driver of cellular differentiation in multicellular organisms; the result is a diverse range of cell types each with their own unique profile of expression. Within these cell types the transcriptional product of a gene is up or down regulated in response to intrinsic and extrinsic stimuli according to its own regulatory programme encoded within the cell. The complexity of this regulatory programme depends on the requirements of the gene to change expression states in different cell lineages or temporally in response to a range of conditions. In the case

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39

Warnefors, Anna Maria Linne´a. "Evolution of human gene expression." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/6979/.

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During evolution, biological differences between species can arise not only due to structural differences between genes, but also following changes in how, where and when genes are active. However, we know much less about this second aspect, because large-scale comparative transcriptomics only became feasible relatively recently. In this thesis, I will therefore investigate several aspects of gene expression evolution, with emphasis on our own species. A first step to understanding regulatory evolution is to determine how variation in gene expression is created. Transposable elements (TEs) are

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40

Sweeney, Glen E. "Differential gene expression in Physarum." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35166.

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Physarum polycephalum has a life-cycle that encompasses two very distinct vegetatively growing cell-types; uninucleate microscopic amoebae, and multinucleate macroscopic plasmodia. cDNA libraries have been prepared from both amoebae and plasmodia using the M13 vector mp8. Clones from the two libraries were screened using a differential hybridisation procedure that identifies clones derived from mRNAs much more abundant in one cell-type than in the other. For both the amoebal library and the plasmodial library it was found that about 5% of the clones represented genes preferentially expressed i

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41

Collier, William. "Gene expression regulation in Pneumoviruses." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102038/.

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Members of the Pneumoviridae virus family are responsible for severe respiratory tract disease in their hosts. Human respiratory syncytial virus (hRSV) is responsible for over 200,000 deaths worldwide each year and bovine respiratory syncytial virus (bRSV) causes major economic loss to the cattle industry worldwide. The current model for all nonsegmented negative-sense single stranded RNA virus gene expression, is that mRNA is generated in a polar gradient, with decreasing levels of mRNA transcribed from genes further along the genome from the 3 ́ end. With the exception of translation of ORF-

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42

Fioroni, Orietta Maria. "Gene expression in cultured cells." Thesis, University of Leicester, 1989. http://hdl.handle.net/2381/35455.

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Dedifferentiation is the process by which specialised quiescent cells give rise to heterotrophic, dividing cells. This process may be initiated in vivo as a response to wounding, or in vitro during culture initiation. This thesis is concerned with evaluating whether the process of dedifferentiation and maintenance of the fast-dividing, dedifferentiated state by culture, is dependant upon major changes in gene expression. In particular, the role of transcription, as mirrored by changes in steady state mRNA levels, in these putative changes in gene expression has been investigated. Mechanically

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43

Heur, J. Martin. "Lysosomal Regulation of Gene Expression." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1026512116.

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44

Gaspar, Paulo Miguel da Silva. "Gene optimization for heterologous expression." Master's thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/7238.

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Mestrado em Engenharia de Computadores e Telemática<br>Com o uso de computadores para assistir investigadores na área da biologia na resolução de tarefas complexas, o seu potencial surgiu como uma ajuda preciosa para alcançar o que está para além das capacidades humanas. Para um biólogo, nos tempos que correm, lidar com um computador é uma tarefa tão trivial como realizar experiencias em laboratório. Assim, a capacidade fornecida pela tecnologia computacional, juntamente com as centenas de aplicações e ferramentas de software que já existem, concedem à Biologia um apoio significativo pa

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45

Lyons, Scott K. "Studies on conditional gene expression." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/21371.

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Using a double replacement targeting approach, I attempted to replace the p53 promoter region with inducible promoter sequence. Targeting constructs were designed to produce a mutant p53 locus, which would then subsequently allow the rapid and simple introduction of a variety of transcriptional regulatory sequences. The first stage vector was introduced into ES cells, and of 508 HAT resistant clones screened, 1 clone possessed a recombinant p53 locus. Time constraints did not permit full characterisation of this clone, either <I>in vitro </I>or <I>in vivo.</I> In a parallel approach, I used on

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46

Mizumoto, Hiroyuki. "Gene Expression Mechanisms of Dianthovirus." Kyoto University, 2004. http://hdl.handle.net/2433/147733.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第10883号<br>農博第1389号<br>新制||農||887(附属図書館)<br>学位論文||H16||N3894(農学部図書室)<br>UT51-2004-G730<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授奥野哲郎, 教授遠藤隆, 教授泉井桂<br>学位規則第4条第1項該当

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Leonard, Pauline Catherine. "Gene expression profiling of osteosarcoma." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445814/.

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Purpose: The aim of the work described in this thesis was to determine whether needle core and open biopsies from osteosarcoma (OS) provide sufficient quality of mRNA for cDNA array analyses which might then provide insights into the expression profile of OS. Experimental Design: Sixteen samples collected from OS and two established cell lines were used for array analyses. A primary cell culture was also established from one of the OS biopsies. Total RNA was extracted and probes generated for cDNA arrays. A reference probe was included for computational analyses. Results: cDNA probes were made

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48

Kim, Michael S. "Gene Expression in Bone Cells." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/366180.

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Osteoclast formation is a complex process that is yet to be clearly defined. Osteoclasts differentiate from monocytic precursors to large multinuclear cells via the actions of two crucial cytokines: macrophage colony stimulating factor (M-CSF) and receptor activator of NFKB ligand (RANKL). These two cytokines bind to the osteoclast precursor cells, activating various down stream signalling pathways, inducing genes required for differentiation and for activation of osteoclasts. Exposure of monocytic precursors to M-CSF alone leads to differentiation into macrophages. Osteoclast differentiation

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49

McCracken, Andrea. "Heterologous gene expression in Lactobacillus." Thesis, Queensland University of Technology, 1998.

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Tufarelli, Cristina. "Activation and silencing of Î± globin expression." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365741.

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