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Relevant bibliographies by topics / Gene Kelly

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Academic literature on the topic 'Gene Kelly'

Author: Grafiati

Published: 24 April 2022

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Journal articles on the topic "Gene Kelly"

1

Mercatelli, Daniele, Nicola Balboni, Alessandro Palma, Emanuela Aleo, Pietro Paolo Sanna, Giovanni Perini, and Federico Manuel Giorgi. "Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines." Biomolecules 11, no. 2 (January 28, 2021): 177. http://dx.doi.org/10.3390/biom11020177.

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Neuroblastoma (NBL) is a pediatric cancer responsible for more than 15% of cancer deaths in children, with 800 new cases each year in the United States alone. Genomic amplification of the MYC oncogene family member MYCN characterizes a subset of high-risk pediatric neuroblastomas. Several cellular models have been implemented to study this disease over the years. Two of these, SK-N-BE-2-C (BE2C) and Kelly, are amongst the most used worldwide as models of MYCN-Amplified human NBL. Here, we provide a transcriptome-wide quantitative measurement of gene expression and transcriptional network activity in BE2C and Kelly cell lines at an unprecedented single-cell resolution. We obtained 1105 Kelly and 962 BE2C unsynchronized cells, with an average number of mapped reads/cell of roughly 38,000. The single-cell data recapitulate gene expression signatures previously generated from bulk RNA-Seq. We highlight low variance for commonly used housekeeping genes between different cells (ACTB, B2M and GAPDH), while showing higher than expected variance for metallothionein transcripts in Kelly cells. The high number of samples, despite the relatively low read coverage of single cells, allowed for robust pathway enrichment analysis and master regulator analysis (MRA), both of which highlight the more mesenchymal nature of BE2C cells as compared to Kelly cells, and the upregulation of TWIST1 and DNAJC1 transcriptional networks. We further defined master regulators at the single cell level and showed that MYCN is not constantly active or expressed within Kelly and BE2C cells, independently of cell cycle phase. The dataset, alongside a detailed and commented programming protocol to analyze it, is fully shared and reusable.

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2

Gordon, Mary Contini. "He’s Got Rhythm: the Life and Career of Gene Kelly." Oral History Review 47, no. 1 (November 5, 2019): 133–34. http://dx.doi.org/10.1080/00940798.2019.1673644.

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3

Stolze, Ineke, Utta Berchner-Pfannschmidt, Patricia Freitag, Christoph Wotzlaw, Jochen Rössler, Stilla Frede, Helmut Acker, and Joachim Fandrey. "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells." Blood 100, no. 7 (October 1, 2002): 2623–28. http://dx.doi.org/10.1182/blood-2001-12-0169.

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Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O2)-dependent manner. However, NB cells had maximal production of EPO with lower partial pressure of O2 values than the well-characterized hepatoma cell line HepG2. This maximal EPO expression was preceded by accumulation of the O2-sensitive α subunit of the heterodimeric transcription-factor complex hypoxia-inducible factor 1 (HIF-1). Western blot analysis revealed that the amount of the β subunit of HIF-1, identical to aryl hydrocarbon receptor nuclear translocator 1 (ARNT1), and the homolog ARNT2 increased in nuclear extracts from SH-SY5Y cells exposed to anoxia. In neuronal cells, ARNT1 and ARNT2 can form a heterodimer with HIF-1α, generating a functional HIF-1 complex. Using the hypoxia response element of the human EPO enhancer, we conducted electrophoretic mobility shift assays that showed accumulation and binding of HIF-1 complexes containing both ARNT1 and ARNT2 in NB cells. In addition to the HIF-1 complex, hepatocyte nuclear factor 4α (HNF4α) was found to be indispensable for hypoxia-induced EPO gene expression in hepatoma cells. Western blot analysis and polymerase chain reaction assessment showed that NB cells express neither HNF4α nor the splicing variant HNF4α7 and thus express EPO in an HNF4α-independent manner. Together, SH-SY5Y and Kelly cells may provide a new in vitro model for studying the mechanism of tissue-specific, hypoxia-inducible EPO gene expression.

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4

Lindberg, Julianne. "The Time of Your Life: Gene Kelly, working-class masculinity, and music." Studies in Musical Theatre 10, no. 2 (June 1, 2016): 177–93. http://dx.doi.org/10.1386/smt.10.2.177_1.

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5

Yang, Xiaofeng, Taissia G. Popova, Martin S. Goldberg, and Michael V. Norgard. "Influence of Cultivation Media on Genetic Regulatory Patterns in Borrelia burgdorferi." Infection and Immunity 69, no. 6 (June 1, 2001): 4159–63. http://dx.doi.org/10.1128/iai.69.6.4159-4163.2001.

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ABSTRACT Barbour-Stoenner-Kelly II (BSKII) medium and BSKH medium both are routinely used for the cultivation of Borrelia burgdorferi. However, heretofore there have been no studies to compare how these two media affect gene expression patterns in virulentB. burgdorferi. In the present study, we found that someB. burgdorferi strain 297 genes (e.g.,ospA, mlp-7A, mlp-8,p22, and lp6.6) that typically are regulated by temperature or pH displayed their predicted pattern of expression when B. burgdorferi was cultivated in BSKH medium; this was not true when spirochetes were cultivated in conventional BSKII medium. The results suggest that BSKH medium is superior to BSKII medium for gene expression studies with B. burgdorferi.

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6

Pattullo, Lauren. "Narrative and spectacle in the Hollywood musical: contrasting the choreography of Busby Berkeley and Gene Kelly." Research in Dance Education 8, no. 1 (April 2007): 73–85. http://dx.doi.org/10.1080/14647890701272878.

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7

Kraut, Anthea. "The Hollywood Dance-In: Abstract and Material Relations of Corporeal Reproduction." Arts 8, no. 4 (October 14, 2019): 133. http://dx.doi.org/10.3390/arts8040133.

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This essay asks what the figure of the Hollywood dance-in—a dancer who performed in place of a star prior to filming and who assisted the choreographer in the creation of dance numbers—can reveal about the reproduction of corporeality as an operation that is both abstract and material. Focusing on the white film star Gene Kelly and his Mexican-born dance-in Alex Romero, the essay shows how the men functioned as literal and virtual doubles for one another in the rehearsal process and argues for an understanding of their relations of reproduction as queer and racially charged.

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8

Blount, Stacye A. "Book Review: The Material Gene: Gender, Race, and Heredity after the Human Genome Project by Kelly Happe." Gender & Society 28, no. 4 (February 21, 2014): 637–38. http://dx.doi.org/10.1177/0891243214524624.

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9

Dedoni, Simona, Luisa Marras, Maria C. Olianas, Angela Ingianni, and Pierluigi Onali. "The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid." International Journal of Molecular Sciences 22, no. 15 (July 21, 2021): 7790. http://dx.doi.org/10.3390/ijms22157790.

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Neurotrophins and their receptors are relevant factors in controlling neuroblastoma growth and progression. The histone deacetylase (HDAC) inhibitor valproic acid (VPA) has been shown to downregulate TrkB and upregulate the p75NTR/sortilin receptor complex. In the present study, we investigated the VPA effect on the expression of the neurotrophin-3 (NT-3) receptor TrkC, a favorable prognostic marker of neuroblastoma. We found that VPA induced the expression of both full-length and truncated (TrkC-T1) isoforms of TrkC in human neuroblastoma cell lines without (SH-SY5Y) and with (Kelly, BE(2)-C and IMR 32) MYCN amplification. VPA enhanced cell surface expression of the receptor and increased Akt and ERK1/2 activation by NT-3. The HDAC inhibitors entinostat, romidepsin and vorinostat also increased TrkC in SH-SY5Y, Kelly and BE(2)-C but not IMR 32 cells. TrkC upregulation by VPA involved induction of RUNX3, stimulation of ERK1/2 and JNK, and ERK1/2-mediated Egr1 expression. In SH-SY5Y cell monolayers and spheroids the exposure to NT-3 enhanced the apoptotic cascade triggered by VPA. Gene silencing of both TrkC-T1 and p75NTR prevented the NT-3 proapoptotic effect. Moreover, NT-3 enhanced p75NTR/TrkC-T1 co-immunoprecipitation. The results indicate that VPA upregulates TrkC by activating epigenetic mechanisms and signaling pathways, and sensitizes neuroblastoma cells to NT-3-induced apoptosis.

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10

Haigh, Andrew J., and Vett K. Lloyd. "Loss of genomic imprinting in Drosophila clones." Genome 49, no. 8 (August 1, 2006): 1043–46. http://dx.doi.org/10.1139/g06-042.

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Genomic imprinting is a process that genetically distinguishes maternal and paternal genomes, and can result in parent-of-origin-dependent monoallelic expression of a gene that is dependent on the parent of origin. As such, an otherwise functional maternally inherited allele may be silenced so that the gene is expressed exclusively from the paternal allele, or vice versa. Once thought to be restricted to mammals, genomic imprinting has been documented in angiosperm plants (J.L. Kermicle. 1970. Genetics, 66: 6985), zebrafish (C.C. Martin and R. McGowan. 1995. Genet. Res. 65: 2128), insects, and C. elegans (C.J. Bean, C.E. Schaner, and W.G. Kelly. 2004. Nat. Genet. 36: 100105.). In each case, it appears to rely on differential chromatin structure. Aberrant imprinting has been implicated in various human cancers and has been detected in a number of cloned mammals, potentially limiting the usefulness of somatic nuclear transfer. Here we show that genomic imprinting associated with a mini-X chromosome is lost in Drosophila melanogaster clones.Key words: cloning, Drosophila, genomic imprinting, nuclear transfer.

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Books on the topic "Gene Kelly"

1

Gene Kelly: A biography. Boston, Mass: G.K. Hall, 1985.

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2

Ball, Murray Hone. Tarzan, Gene Kelly, and me. Gisborne, N.Z: Diogenes Designs, 2001.

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3

Yudkoff, Alvin. Gene Kelly: A life of dance and dreams. Thorndike, Me: Thorndike Press, 2000.

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4

Yudkoff, Alvin. Gene Kelly: A life of dance and dreams. New York: Back Stage Books, 2001.

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5

The films of Gene Kelly: Song anddance man. New York: Carol, 1991.

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6

Yudkoff, Alvin. Gene Kelly: A life of dance and dreams. New York: Back Stage Books, 1999.

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7

Polla, Franco La. Stanley Donen, Gene Kelly: Cantando sotto la pioggia. Torino: Lindau, 1997.

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8

Perez, Adolfo. Gene Kelly. Edimat Libros, 1998.

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9

Fogarty, Mary. Gene Kelly. Edited by Melissa Blanco Borelli. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199897827.013.008.

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This chapter explores the contemporary significance of Gene Kelly for street dance practitioners and cultural critics. Responses to a Volkswagen commercial remake of Kelly’s “Singin’ in the Rain” solo sequence raise questions about how creativity and originality are assessed in popular dance performances. By comparing the responses of film critics and hip-hop dance practitioners to both Gene Kelly’s performance in Singin’ in the Rain (Donen and Kelly 1952) and the commercial remake, a key theme emerges. Evaluations of creativity reveal how judgments about originality are as much a part of street dance practices as classic choreographic works. This chapter suggests that “remixes” of past popular dance performances reveal the pleasure created in aesthetic comparison. In fact, value judgments rooted in comparisons are a central component of popular dance assessment and appreciation.

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10

Masson. Gene Kelly. Gallimard, 2012. http://dx.doi.org/10.14375/np.9782070439423.

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Book chapters on the topic "Gene Kelly"

1

"Front Matter." In Gene Kelly, i—vi. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.1.

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2

"Taking on Hollywood, 1941–1944." In Gene Kelly, 97–130. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.10.

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"Dancing Sailor, 1944–1946." In Gene Kelly, 131–65. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.11.

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4

"Restarting His Career, 1946–1948." In Gene Kelly, 166–88. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.12.

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"Red Scare—First Wave, 1946–1949." In Gene Kelly, 189–206. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.13.

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6

"Surging to the Top, 1948–1949." In Gene Kelly, 207–32. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.14.

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7

"Zenith, 1949–1952." In Gene Kelly, 233–58. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.15.

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8

"Turning Point, 1951–1953." In Gene Kelly, 259–79. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.16.

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9

"Red Scare—Second Wave, 1950–1954." In Gene Kelly, 280–89. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.17.

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10

"Sunset of the Golden Age, 1953–1955." In Gene Kelly, 290–303. University Press of Kansas, 2021. http://dx.doi.org/10.2307/j.ctv1d5nktb.18.

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