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Journal articles on the topic 'Gene Kelly'

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Published: 24 April 2022

Last updated: 30 July 2025

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1

Mercatelli, Daniele, Nicola Balboni, Alessandro Palma, et al. "Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines." Biomolecules 11, no. 2 (2021): 177. http://dx.doi.org/10.3390/biom11020177.

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Neuroblastoma (NBL) is a pediatric cancer responsible for more than 15% of cancer deaths in children, with 800 new cases each year in the United States alone. Genomic amplification of the MYC oncogene family member MYCN characterizes a subset of high-risk pediatric neuroblastomas. Several cellular models have been implemented to study this disease over the years. Two of these, SK-N-BE-2-C (BE2C) and Kelly, are amongst the most used worldwide as models of MYCN-Amplified human NBL. Here, we provide a transcriptome-wide quantitative measurement of gene expression and transcriptional network activ

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2

Bass, Jeremy. "East River, and: Where Are You, Gene Kelly?" New England Review 32, no. 1 (2011): 74–76. http://dx.doi.org/10.1353/ner.2011.a433213.

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3

Gordon, Mary Contini. "He’s Got Rhythm: the Life and Career of Gene Kelly." Oral History Review 47, no. 1 (2019): 133–34. http://dx.doi.org/10.1080/00940798.2019.1673644.

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4

Stolze, Ineke, Utta Berchner-Pfannschmidt, Patricia Freitag, et al. "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells." Blood 100, no. 7 (2002): 2623–28. http://dx.doi.org/10.1182/blood-2001-12-0169.

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Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O2)-dependent manner. However, NB cells had maximal production of EPO with lower partial pressure of O2 values than the well-characterized hepatoma cell line HepG2. This maximal EPO expression was preceded by accumulation of the O2-sensitive α subunit of the heterodimeric transcription-factor complex hypoxia-inducible factor 1 (HIF-1). Western blot analysis revealed that the amount of the β subunit of HIF-1, identical to aryl hydrocarbon receptor nuclear translocato

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5

Lindberg, Julianne. "The Time of Your Life: Gene Kelly, working-class masculinity, and music." Studies in Musical Theatre 10, no. 2 (2016): 177–93. http://dx.doi.org/10.1386/smt.10.2.177_1.

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6

Obata, Honoka, Atsushi B. Tsuji, Hitomi Sudo, et al. "Novel Auger-Electron-Emitting 191Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma." Pharmaceuticals 16, no. 11 (2023): 1526. http://dx.doi.org/10.3390/ph16111526.

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Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considering that the cancer genome is maintained under abnormal gene amplification and expression, here, we developed a novel 191Pt-labeled agent based on pyrrole–imidazole polyamide (PIP), targeting the oncogene MYCN amplified in human neuroblastoma, and investigated its targeting ability and damaging effects. A conjugate of MYCN-targeting PIP and Cys-(Arg)

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7

Yang, Xiaofeng, Taissia G. Popova, Martin S. Goldberg, and Michael V. Norgard. "Influence of Cultivation Media on Genetic Regulatory Patterns in Borrelia burgdorferi." Infection and Immunity 69, no. 6 (2001): 4159–63. http://dx.doi.org/10.1128/iai.69.6.4159-4163.2001.

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ABSTRACT Barbour-Stoenner-Kelly II (BSKII) medium and BSKH medium both are routinely used for the cultivation of Borrelia burgdorferi. However, heretofore there have been no studies to compare how these two media affect gene expression patterns in virulentB. burgdorferi. In the present study, we found that someB. burgdorferi strain 297 genes (e.g.,ospA, mlp-7A, mlp-8,p22, and lp6.6) that typically are regulated by temperature or pH displayed their predicted pattern of expression when B. burgdorferi was cultivated in BSKH medium; this was not true when spirochetes were cultivated in conventiona

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8

Kraut, Anthea. "The Hollywood Dance-In: Abstract and Material Relations of Corporeal Reproduction." Arts 8, no. 4 (2019): 133. http://dx.doi.org/10.3390/arts8040133.

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This essay asks what the figure of the Hollywood dance-in—a dancer who performed in place of a star prior to filming and who assisted the choreographer in the creation of dance numbers—can reveal about the reproduction of corporeality as an operation that is both abstract and material. Focusing on the white film star Gene Kelly and his Mexican-born dance-in Alex Romero, the essay shows how the men functioned as literal and virtual doubles for one another in the rehearsal process and argues for an understanding of their relations of reproduction as queer and racially charged.

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9

Pattullo, Lauren. "Narrative and spectacle in the Hollywood musical: contrasting the choreography of Busby Berkeley and Gene Kelly." Research in Dance Education 8, no. 1 (2007): 73–85. http://dx.doi.org/10.1080/14647890701272878.

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10

Dedoni, Simona, Luisa Marras, Maria C. Olianas, Angela Ingianni, and Pierluigi Onali. "The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid." International Journal of Molecular Sciences 22, no. 15 (2021): 7790. http://dx.doi.org/10.3390/ijms22157790.

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Neurotrophins and their receptors are relevant factors in controlling neuroblastoma growth and progression. The histone deacetylase (HDAC) inhibitor valproic acid (VPA) has been shown to downregulate TrkB and upregulate the p75NTR/sortilin receptor complex. In the present study, we investigated the VPA effect on the expression of the neurotrophin-3 (NT-3) receptor TrkC, a favorable prognostic marker of neuroblastoma. We found that VPA induced the expression of both full-length and truncated (TrkC-T1) isoforms of TrkC in human neuroblastoma cell lines without (SH-SY5Y) and with (Kelly, BE(2)-C

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11

Blount, Stacye A. "Book Review: The Material Gene: Gender, Race, and Heredity after the Human Genome Project by Kelly Happe." Gender & Society 28, no. 4 (2014): 637–38. http://dx.doi.org/10.1177/0891243214524624.

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12

Milazzo, Giorgio, Giovanni Perini, and Federico M. Giorgi. "Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells." Genes 13, no. 12 (2022): 2240. http://dx.doi.org/10.3390/genes13122240.

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The molecular mechanisms and gene regulatory networks sustaining cell proliferation in neuroblastoma (NBL) cells are still not fully understood. In this tumor context, it has been proposed that anti-proliferative drugs, such as the pan-HDAC inhibitor panobinostat, could be tested to mitigate tumor progression. Here, we set out to investigate the effects of panobinostat treatment at the unprecedented resolution offered by single-cell sequencing. We identified a global senescence signature paired with reduction in proliferation in treated Kelly cells and more isolated transcriptional responses c

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13

Haigh, Andrew J., and Vett K. Lloyd. "Loss of genomic imprinting in Drosophila clones." Genome 49, no. 8 (2006): 1043–46. http://dx.doi.org/10.1139/g06-042.

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Genomic imprinting is a process that genetically distinguishes maternal and paternal genomes, and can result in parent-of-origin-dependent monoallelic expression of a gene that is dependent on the parent of origin. As such, an otherwise functional maternally inherited allele may be silenced so that the gene is expressed exclusively from the paternal allele, or vice versa. Once thought to be restricted to mammals, genomic imprinting has been documented in angiosperm plants (J.L. Kermicle. 1970. Genetics, 66: 6985), zebrafish (C.C. Martin and R. McGowan. 1995. Genet. Res. 65: 2128), insects, a

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14

Jedrusik, M. A., and E. Schulze. "A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans." Development 128, no. 7 (2001): 1069–80. http://dx.doi.org/10.1242/dev.128.7.1069.

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In remarkable contrast to somatic cells, the germline of the nematode Caenorhabditis elegans efficiently silences transgenic DNA. The molecular mechanisms responsible for this have been shown to implicate chromatin proteins encoded by the mes genes (Kelly, W. G. and Fire, A. (1998) Development 125, 2451–2456), of which two are the C. elegans homologs of Polycomb Group gene transcriptional repressors. We have analyzed the contribution of the histone H1 gene family to this specific aspect of germ cells in C. elegans. We show with isotype-specific double stranded RNA-mediated interference (RNAi)

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15

Bononi, Angela, Paul Redford, Weichao Zhang, et al. "Abstract 563: AR-dependent castration-resistant prostate cancer relies on histone methyltransferase KMT2D for cell growth." Cancer Research 85, no. 8_Supplement_1 (2025): 563. https://doi.org/10.1158/1538-7445.am2025-563.

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The KMT2D histone H3 lysine 4 (H3K4) methyltransferase plays critical roles in enhancer-regulated gene activation. It is a large multi-domain protein with its C-terminal SET domain being responsible for this activity. High KMT2D expression is associated with reduced patient survival in prostate cancer. Cancer Dependency Map data show a correlation between KMT2D gene dependency and FOXA1 expression in prostate cancer cell lines. FOXA1 is a major regulator of Androgen Receptor (AR) transcription and recent findings showed that KMT2D establishes the chromatin competency to recruit AR and for FOXA

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16

Toulza, Pierre-Olivier. "Un Américain « plus parisien que la plupart des Parisiens « : la popularité de Gene Kelly en France dans les années 1950." Contemporary French and Francophone Studies 19, no. 1 (2014): 106–20. http://dx.doi.org/10.1080/17409292.2015.982436.

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17

Genné, Beth. "“FREEDOM INCARNATE”: JEROME ROBBINS, GENE KELLY, AND THE DANCING SAILOR AS AN ICON OF AMERICAN VALUES IN WORLD WAR II." Dance Chronicle 24, no. 1 (2001): 83–103. http://dx.doi.org/10.1081/dnc-100103142.

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18

Kanaan, Yasmine, Sylvia Dasi, Bernard Kwabi-Addo та ін. "Abstract P5-01-18: ESRα and RASSF1A promoter methylation changed significantly in benign tumors and in the early event of breast cancer progression". Clinical Cancer Research 31, № 12_Supplement (2025): P5–01–18—P5–01–18. https://doi.org/10.1158/1557-3265.sabcs24-p5-01-18.

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Abstract Methylation in the estrogen receptor alpha (ESRa) promoter is an epigenetic abnormality in breast cancer (BCa) and hypermethylation-mediated loss of ESRa expression could provide the cell with growth-promoting characteristics such as insensitivity to antigrowth signals. To investigate if there is a direct link between P0/P1 promoters of ESRa aberrant methylation and risk of progression of the fibroadenoma and fibrocystic diseasee to BCa. Methodology: We used pyrosequencing to assess the DNA methylation in a panel of genes (ESRa, RASSF1A, and HIN1) in benign and cancerous human breast

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19

Tee, Annli, Andrew J. Kueh, Leonie Gibson, et al. "Abstract 1379: Discovering the essential functions of MCL-1 in hematopoiesis using gene-swap mice." Cancer Research 85, no. 8_Supplement_1 (2025): 1379. https://doi.org/10.1158/1538-7445.am2025-1379.

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Pro-survival BCL-2 proteins (e.g., MCL-1, BCL-XL, BCL-2, A1) are over-expressed in human cancers, making them critical targets for anti-cancer therapies 1. While the BCL-2 inhibitor Venetoclax is highly successful in treating certain blood cancers, inhibitors of BCL-XL and MCL-1 cause toxicity to non-malignant tissues, including hematopoietic cells 2. These findings from gene targeted mice showed that different pro-survival BCL-2 proteins are critical for the survival of distinct hematopoietic cell subsets. Notably, MCL-1 is essential for implantation, with Mcl-1-/- embryos dying at E3.5, the

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20

Lee, Pui Y., Yutaro Kumagai, Yi Li та ін. "TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus". Journal of Experimental Medicine 205, № 13 (2008): 2995–3006. http://dx.doi.org/10.1084/jem.20080462.

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Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for dysregulated IFN-I production in SLE remain unclear, autoantibody-mediated uptake of endogenous nucleic acids is thought to play a role. 2,6,10,14-tetramethylpentadecane (TMPD; also known as pristane) induces a lupus-like disease in mice characterized by immune complex nephritis with autoantibodies to DNA and ribonucleoproteins. We recently reported that TMPD also causes increased ISG expression and

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21

Kraut, Anthea. "Female Surrogate Labor and White Corporeal Debt in Singin’ in the Rain." Camera Obscura: Feminism, Culture, and Media Studies 36, no. 2 (2021): 1–31. http://dx.doi.org/10.1215/02705346-9052774.

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Abstract This essay revisits the question of credit and debt in the celebrated 1952 film musical Singin’ in the Rain (dir. Gene Kelly and Stanley Donen, US) to show how white women's dancing bodies participate in the “talent relocations” that the movie both thematizes and suppresses. Specifically, it focuses on the relationship between Debbie Reynolds, who was a novice dancer when she was cast in the film, and the two other white women dancers who helped shape Reynolds's filmic body: assistant choreographer Carol Haney and dance-in Jeanne Coyne. Combining feminist and critical race perspective

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22

Fesler, Melissa C., Marianne J. Middelveen, Jennie M. Burke, and Raphael B. Stricker. "Erosive Vulvovaginitis Associated With Borrelia burgdorferi Infection." Journal of Investigative Medicine High Impact Case Reports 7 (January 2019): 232470961984290. http://dx.doi.org/10.1177/2324709619842901.

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We describe a case of acute erosive vulvovaginitis accompanying Borrelia burgdorferi infection. The patient is a 57-year-old woman previously diagnosed with Lyme disease who presented with a painful erosive genital lesion. At the time of the outbreak, she was being treated with oral antibiotics, and she tested serologically positive for B burgdorferi and serologically negative for syphilis. Histological examination of biopsy tissue from the lesion was not characteristic of dermatopathological patterns typical of erosive vulvar conditions. Dieterle-stained biopsy sections revealed visible spiro

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23

Rajan, Govind, Robert Victor, Richard Kelly, Ryan Cockrill, Karen Katrivesis, and Corey Nelson. "A rare case of late onset malignant hyperthermia." Anaesthesia, Pain & Intensive Care 26, no. 4 (2022): 546–50. http://dx.doi.org/10.35975/apic.v26i4.1963.

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A 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights malignant hyperthermia’s (MH) variable time course, pathognomonic signs, and the need for rapid diagnosis and treatment. Early recognition and treatment led to rapid resolution of MH. Ongoing discussion of MH is imperative because this disease is often difficult to diagnose early in its time course and may be fatal if not treated expeditiously. Abbreviatio

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24

Becker, Svea, and Bruce Williams. "What ever happened toWest Side Story? Gene Kelly, jazz dance, and not so real men in Jacques Demy'sThe Young Girls of Rochefort." New Review of Film and Television Studies 6, no. 3 (2008): 303–21. http://dx.doi.org/10.1080/17400300802418610.

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25

Lenardo, M. J., K. M. Esser, A. M. Moon, L. H. Van der Ploeg, and J. E. Donelson. "Metacyclic variant surface glycoprotein genes of Trypanosoma brucei subsp. rhodesiense are activated in situ, and their expression is transcriptionally regulated." Molecular and Cellular Biology 6, no. 6 (1986): 1991–97. http://dx.doi.org/10.1128/mcb.6.6.1991-1997.1986.

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During the metacyclic stage in the life cycle of Trypanosoma brucei subsp. rhodesiense, the expression of variant surface glycoproteins (VSGs) is restricted to a small subset of antigenic types. Previously we identified cDNAs for the VSGs expressed in metacyclic variant antigen types (MVATs) 4 and 7 and found that these VSG genes do not rearrange when expressed at the metacyclic stage (M. J. Lenardo, A. C. Rice-Ficht, G. Kelly, K. Esser, and J. E. Donelson, Proc. Nathl. Acad Sci. USA 81:6642-6646, 1984). We now provide further evidence that these genes do not rearrange and demonstrate that the

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26

Lenardo, M. J., K. M. Esser, A. M. Moon, L. H. Van der Ploeg, and J. E. Donelson. "Metacyclic variant surface glycoprotein genes of Trypanosoma brucei subsp. rhodesiense are activated in situ, and their expression is transcriptionally regulated." Molecular and Cellular Biology 6, no. 6 (1986): 1991–97. http://dx.doi.org/10.1128/mcb.6.6.1991.

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During the metacyclic stage in the life cycle of Trypanosoma brucei subsp. rhodesiense, the expression of variant surface glycoproteins (VSGs) is restricted to a small subset of antigenic types. Previously we identified cDNAs for the VSGs expressed in metacyclic variant antigen types (MVATs) 4 and 7 and found that these VSG genes do not rearrange when expressed at the metacyclic stage (M. J. Lenardo, A. C. Rice-Ficht, G. Kelly, K. Esser, and J. E. Donelson, Proc. Nathl. Acad Sci. USA 81:6642-6646, 1984). We now provide further evidence that these genes do not rearrange and demonstrate that the

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27

McGill, London P., Kelly H. Banas, Gregory Tiesi, and Eric B. Kmiec. "Abstract A010: A patient first approach using CRISPR-directed gene editing as an augmentative therapy for the treatment of pancreatic ductile adenocarcinoma." Cancer Research 84, no. 17_Supplement_2 (2024): A010. http://dx.doi.org/10.1158/1538-7445.pancreatic24-a010.

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Abstract At the Gene Editing Institute, we are advancing a novel strategy for the treatment of pancreatic ductile adenocarcinoma by employing CRISPR-directed gene editing to disable the functions of key genes that block effective drug application including chemotherapy, radiation and immunotherapy. No matter how careful one is at designing a specific drug against a specific protein, ultimately, the tumor cell develops a workaround. A paradigm shift is required to truly overcome this formidable barrier. We’ve accomplished this by leveraging the effectiveness of standard care and augmenting it,

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Page, David, Alan Su, Nicole Moxon, et al. "Abstract PO2-03-10: Association of pathologic complete response with the 27-gene IO score and week 3 IOpath response following neoadjuvant pembrolizumab +/- intralymphatic cytokines in the neoIRX trial." Cancer Research 84, no. 9_Supplement (2024): PO2–03–10—PO2–03–10. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-03-10.

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Abstract Introduction: Novel biomarker strategies are needed to identify immunotherapy (IO)-sensitive early-stage triple-negative breast cancers (TNBC). We recently reported a phase II trial (neoIRX, NCT04373031) evaluating induction IO (pembrolizumab +/- intralymphatic cytokines, IRX-2, comprised of physiologic doses of IL-2, IFNγ, and other cytokines derived from activated donor lymphocytes) preceding de-escalated neoadjuvant chemotherapy (NAC). Here, we report associations of response with the 27-gene IO score (DetermaIO), a commercially available RT-qPCR assay shown to predict IO response

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29

Irving, S. G., C. H. June, P. F. Zipfel, U. Siebenlist, and K. Kelly. "Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation." Molecular and Cellular Biology 9, no. 3 (1989): 1034–40. http://dx.doi.org/10.1128/mcb.9.3.1034-1040.1989.

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The delivery of a mitogenic signal to T cells via any one of several cell surface molecules elicits a variety of intracellular responses, some or all of which regulate subsequent gene expression events. The expression of nine novel mitogen-induced genes in response to various T-cell-activating agents was examined to evaluate the diversity of pathways which regulate such genes. The relative contribution of distinct secondary signals, individually or together, to mitogen-stimulated gene induction and the capability of individual genes to respond to the sometimes divergent signals generated from

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Irving, S. G., C. H. June, P. F. Zipfel, U. Siebenlist, and K. Kelly. "Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation." Molecular and Cellular Biology 9, no. 3 (1989): 1034–40. http://dx.doi.org/10.1128/mcb.9.3.1034.

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The delivery of a mitogenic signal to T cells via any one of several cell surface molecules elicits a variety of intracellular responses, some or all of which regulate subsequent gene expression events. The expression of nine novel mitogen-induced genes in response to various T-cell-activating agents was examined to evaluate the diversity of pathways which regulate such genes. The relative contribution of distinct secondary signals, individually or together, to mitogen-stimulated gene induction and the capability of individual genes to respond to the sometimes divergent signals generated from

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31

Yermalovich, Alena, Zarin Mohsenin, Bruno Giotti, et al. "Abstract 4583: An essential role for Cmtr2 in endothelial cell function and vascular development." Cancer Research 83, no. 7_Supplement (2023): 4583. http://dx.doi.org/10.1158/1538-7445.am2023-4583.

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Abstract Cancer genome sequencing studies have identified multiple novel tumor suppressor genes, including the FTSJD1 or CMTR2 gene that is subject to statistically significant levels of both nonsense and frameshift mutations in lung adenocarcinoma. However, these analyses are insufficient to determine the importance and modes of action of the gene in the disease. Follow-up functional studies are essential to elucidate these gene functions. The protein product of CMTR2 has been described as an mRNA cap methyltransferase, which O-methylates the ribose of the second guanine residue of the 5’ cap

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32

Naito, Yutaka, Robert Hynds, David Novo, et al. "Abstract 674: Tracking the transcriptome of lung cancer-associated fibroblasts within the TRACERx lung study from patient to culture models reveals phenotypic plasticity and instructive cues from cancer cells." Cancer Research 82, no. 12_Supplement (2022): 674. http://dx.doi.org/10.1158/1538-7445.am2022-674.

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Abstract Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression by enhancing extracellular matrix remodeling, cancer cell invasion, and mediating inflammatory environment. Therefore, CAFs have become targets for cancer therapies. However, a major hurdle to developing such therapies are the challenges of studying CAFs in culture - specifically it remains unclear which CAF functions and phenotypes are sustained during in vitro culture and the signaling pathways driving distinct CAF phenotypes. We investigated whether CAF phenotypes and functions are sustained or changed d

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Neumann, Chase, Harish Shankaran, Kiran Nadella, et al. "Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)." Cancer Research 84, no. 6_Supplement (2024): 7133. http://dx.doi.org/10.1158/1538-7445.am2024-7133.

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Abstract Phenomics-enabled drug discovery is a powerful approach to identify novel targets and relationships previously unappreciated in biology. We built a phenomics platform leveraging high content microscopy and generated unique phenoprints for &gt;7,000 genes using CRISPR/Cas9 technology and a diverse chemical library of &gt;1 million compounds. This phenomics dataset contains an unprecedented quantity of gene-gene, gene-compound, and compound-compound relationships. We applied our phenomics platform and an inference based target-agnostic drug discovery approach to discover novel g

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34

LEE, Gha Young, Nam Hee KIM, Zheng-Shan ZHAO, Bong Soo CHA, and Y. Sam KIM. "Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level." Biochemical Journal 378, no. 3 (2004): 983–90. http://dx.doi.org/10.1042/bj20031565.

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MCD (malonyl-CoA decarboxylase), which catalyses decarboxylation of malonyl-CoA, is known to play an important role in the regulation of malonyl-CoA concentration. Recently, it has been observed that the expression of MCD is significantly decreased in the hearts of the PPARα (peroxisome-proliferator-activated receptor α) (−/−) mice, where the rate of fatty-acid oxidation is decreased by the increased malonyl-CoA level [Campbell, Kozak, Wagner, Altarejos, Dyck, Belke, Severson, Kelly and Lopaschuk (2002) J. Biol. Chem. 277, 4098–4103]. This suggests that MCD may be transcriptionally regulated b

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35

Ferreira, Kelly P., Bruna C. Almeida та Katia C. Carvalho. "Abstract 5581: Melatonin and 17β-estradiol treatment modulating TIMP’s family gene expression profile in IDCC". Cancer Research 85, № 8_Supplement_1 (2025): 5581. https://doi.org/10.1158/1538-7445.am2025-5581.

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Introduction: Tissue Inhibitor of Metalloproteinases (TIMPs) are genes that encodes four (TIMP1-4) proteins that act as endogenous protease inhibitors. They regulate directly the matrix metalloproteinases (MMPs) known to be associated with growth and invasiveness of sundry cancer types, including breast cancer cells. Several evidences have shown that melatonin can present both anti-proliferative and invasiveness role in cancer, while estrogen seems to have the opposite function. Thus, our goal was to evaluate the expression of TIMPs’ family compounds in invasive ductal carcinoma cells (IDCC) o

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36

Martin, Kelly, Connor Kunihiro, Jawad Abousoud, et al. "Abstract 995: Preservation of patient whole blood preserves cancer immune cell biology at single cell resolution." Cancer Research 84, no. 6_Supplement (2024): 995. http://dx.doi.org/10.1158/1538-7445.am2024-995.

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Abstract Blood is an easily accessible clinical sample type that helps inform treatments, investigate disease mechanisms, and monitor outcomes. Logistical challenges in the transportation and processing of blood samples impact data output from single cell RNA sequencing (scRNA-seq). Recent scRNA-seq studies have shown that significant changes in gene expression and immune cell populations occur in as little as a few hours post collection. Thus, there is a need for rapid preservation of blood upon collection before biological changes can occur. Existing preservation approaches compromise the ce

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Ibrahim, Milad, Irineu Illa-Bochaca, George Jour, et al. "Abstract 4703: EGFR is a promising therapeutic target in NF1 mutant melanoma." Cancer Research 85, no. 8_Supplement_1 (2025): 4703. https://doi.org/10.1158/1538-7445.am2025-4703.

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Abstract Background: Molecularly targeted therapies and immunotherapy improved treatment outcomes for melanoma patients. However, patients with driver mutations in the Neurofibromin 1 (NF1) tumor suppressor gene, which represent 20-30% of melanomas, have not benefitted from these treatment advances, underscoring an unmet clinical need. Methods: We compared 13 NF1 mutant (NF1Mut) and 19 NF1 wild-type (NF1WT) patient-derived short-term cultures (STCs) integrating multi-omic analysis of DNA mutations (Whole Exome Sequencing), RNA expression, and gene regulation (RNA-Seq, ATAC-Seq, H3K4Me3 and H3K

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Olea, Ximena Diaz, Kristin Beede, Andrei Osterman, et al. "Abstract 6685: Control of melanoma development by B. rodentium in germ free mice." Cancer Research 84, no. 6_Supplement (2024): 6685. http://dx.doi.org/10.1158/1538-7445.am2024-6685.

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Abstract Growing evidence supports the importance of the gut microbiota in controlling tumor development, often via activation of anti-tumor immunity. Earlier studies from our laboratory identified 11 bacterial strains that were sufficient to inhibit melanoma development by inducing anti-tumor immunity in germ-free mice. Of these, three were predominant at the time of tumor collection. We thus set out to address whether fewer bacterial strains may be sufficient for melanoma growth inhibition. Here, we demonstrate that the administration of one bacterial strain, B. rodentium, was sufficient to

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Muller, Lars U. W., Michael Milsom, Chad E. Harris, Jeff Bailey, and David A. Williams. "The Sooner the Better: Rapid Transduction Enhances the Engraftment/Selection of Gene Corrected Fanconi Anemia HSC." Blood 110, no. 11 (2007): 194. http://dx.doi.org/10.1182/blood.v110.11.194.194.

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Abstract Fanconi anemia (FA) is amenable to genetic correction of hematopoietic stem cells (HSCs). However, as demonstrated in previous clinical gene therapy trials, successful extension of murine studies into human therapies is limited by low numbers of target HSC and poor engraftment of transduced FA HSC (Kelly et al., Mol Ther, 2007). To examine the potential biological consequences/benefits of shortened transduction we used a FA mouse model in which HSC are deficient and prone to excessive loss during in vitro manipulation. We applied a rapid transduction protocol (Mostoslavsky et al., Mol

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Pissaridou, Panayiota, Athina Papatheodoulou, Gregoris Notarides, et al. "Novel DNA-based test for the identification of benthic diatoms of European freshwater waterbodies (WAT-DIMON)." ARPHA Conference Abstracts 4 (March 4, 2021): e65203. https://doi.org/10.3897/aca.4.e65203.

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Diatoms are unicellular eukaryotic organisms, which have been exploited over the years for effective freshwater bioassessment. Therefore, they are excellent bioindicators, routinely used in national environmental monitoring programs all over Europe within the Water Framework Directive (WFD) 2000/60 /EC (Foster et al., 2000) and CEN standards (CEN, 2018).Over the years, new technologies have been introduced to this field to maximise and improve the time and cost required for freshwater bioassessment. The application of DNA metabarcoding for the characterisation of benthic diatom communities for

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Gulla, Surendra, Jonathan E. Bard, David J. VanderWeele, Kathleen Kelly, and Remi Adelaiye-Ogala. "Abstract 3989: EVI1 oncogenic role in non-canonical AR driven lethal prostate cancer." Cancer Research 83, no. 7_Supplement (2023): 3989. http://dx.doi.org/10.1158/1538-7445.am2023-3989.

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Abstract Background: Androgen receptor (AR) remains active in castration-resistant prostate cancer (CRPC), and AR cistrome can become extensively reprogrammed with disease progression. Recent findings from our group and others have shown an association with non-canonical AR signature with resistance to enzalutamide. However, the complete mechanism is not fully revealed. EVI1 belongs to the zinc-finger transcription factor family, and overexpression of EVI1 is associated with poor patient outcomes. However, its role in the context of resistance to AR-targeted therapy remains unclear. Our prelim

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Gulla, Surendra, Jonathan E. Bard, David J. VanderWeele, Kathleen Kelly, and Remi Adelaiye-Ogala. "Abstract B003: EVI1 oncogenic role in non-canonical AR driven lethal prostate cancer." Cancer Research 83, no. 11_Supplement (2023): B003. http://dx.doi.org/10.1158/1538-7445.prca2023-b003.

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Abstract Androgen receptor (AR) remains active in castration-resistant prostate cancer (CRPC), and AR cistrome can become extensively reprogrammed with disease progression. Recent findings from our group and others have shown an association with non-canonical AR signature with resistance to enzalutamide. However, the complete mechanism is not fully revealed. EVI1 belongs to the zinc-finger transcription factor family, and overexpression of EVI1 is associated with poor patient outcomes. However, its role in the context of resistance to AR-targeted therapy remains unclear. Our preliminary data f

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Hoffman, Timothy, Melat Gebru, Aaron Boudreau, et al. "Abstract B017: Loss of UXS1 selectively kills KEAP1 mutant cancer cell lines by depleting pyrimidines and inducing replication stress." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): B017. http://dx.doi.org/10.1158/1538-8514.synthleth24-b017.

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Abstract Kelch-like ECH Associated-Protein 1 (KEAP1) is the third most mutated gene in non-small cell lung cancer and is associated with poor prognosis. KEAP1 targets nuclear factor erythroid 2-related factor 2 (Nrf2) for degradation, hence KEAP1-mutated tumors have elevated Nrf2 levels and constitutive expression of its transcriptional targets. To identify potential therapeutic targets for KEAP1 mutated tumors, we interrogated the cancer Dependency Map (DepMap) database and identified UDP Xylose Synthase 1 (UXS1) as a synthetic lethal interaction gene in KEAP1 mutated cancer cell lines. UXS1

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Singh, Ratnakar, Kelly Kries, Aayush Gupta, et al. "Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 6687. https://doi.org/10.1158/1538-7445.am2025-6687.

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Abstract Testicular germ cell tumors (TGCTs) are the most common type of cancer among young men, and incidence has increased over the past 40 years. Approximately 80% of patients with metastatic TGCTs can be cured with chemotherapy; however, those patients that develop resistance to treatment often have a poor prognosis. Despite efforts to identify clear genetic factors that determine chemotherapy sensitivity and resistance in TGCTs, recent research has shifted focus toward the role of epigenetics in maintaining sensitivity to drugs like cisplatin and decitabine. Epigenetic mechanisms, includi

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Heredia Negron, Frances L., Homer W. Fogle, Michael R. Kelly, Kamila Wisniewska, Lisa A. Carey, and Hector L. Franco. "Abstract 5277: Defining the enhancer logic of breast cancer metastasis using transcriptional and chromatin accessibility profiling." Cancer Research 85, no. 8_Supplement_1 (2025): 5277. https://doi.org/10.1158/1538-7445.am2025-5277.

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Abstract Breast cancer metastasis poses a significant challenge in cancer treatment, underscoring the need to understand the molecular mechanisms involved. In this project, we generated a resource dataset that includes ATAC-seq and RNA-seq data from ER positive primary breast tumors and matched liver and lung metastases. We collected samples from four patients at diagnosis in addition to samples from eight patients at autopsy following cancer-related death, allowing us to gain insights into the molecular mechanisms driving metastasis. Our research centered on the hypothesis that cancer cells u

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Cluss, Robert G., Damon A. Silverman, and Thomas R. Stafford. "Extracellular Secretion of the Borrelia burgdorferi Oms28 Porin and Bgp, a Glycosaminoglycan Binding Protein." Infection and Immunity 72, no. 11 (2004): 6279–86. http://dx.doi.org/10.1128/iai.72.11.6279-6286.2004.

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ABSTRACT Borrelia burgdorferi, the Lyme disease pathogen, cycles between its Ixodes tick vector and vertebrate hosts, adapting to vastly different biochemical environments. Spirochete gene expression as a function of temperature, pH, growth phase, and host milieu is well studied, and recent work suggests that regulatory networks are involved. Here, we examine the release of Borrelia burgdorferi strain B31 proteins into conditioned medium. Spirochetes intrinsically radiolabeled at concentrations ranging from 107 to 109 cells per ml secreted Oms28, a previously characterized outer membrane porin

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Güner, Ece S., Naoya Hashimoto, Teruki Kadosaka, Yasuyuki Imai, and Toshiyuki Masuzawa. "A novel, fast-growing Borrelia sp. isolated from the hard tick Hyalomma aegyptium in Turkey." Microbiology 149, no. 9 (2003): 2539–44. http://dx.doi.org/10.1099/mic.0.26464-0.

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A novel, fast-growing spirochaete was isolated from the hard tick Hyalomma aegyptium (family Ixodidae, subfamily Metastriata) using Barbour–Stoenner–Kelly (BSK) II medium. Tick samples were taken during the summer of 2000 from the Istanbul area in northwestern Turkey. Sixty-seven of 153 adults (44 %) and 72 of 185 nymphs (39 %) were infected with the novel spirochaete, whereas none of the 20 larvae examined were infected. The optimal growth temperature of the spirochaete in BSK II medium was 34–37 °C, and it could grow at 39 °C. Doubling times at 34 and 37 °C were 5·3 and 5·1 h, respectively.

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Michaud, Daniel, Kenichi Shimada, Kelly Zheng, et al. "Abstract A042: Characterization of the hormone receptor-positive breast tumor immune microenvironment using single cell transcriptomics and multiplex immunofluorescence." Cancer Research 84, no. 3_Supplement_1 (2024): A042. http://dx.doi.org/10.1158/1538-7445.advbc23-a042.

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Abstract Hormone receptor-positive (HR+) breast tumors are the most frequently diagnosed type of breast cancer (~70%) and are characterized by the expression of the estrogen receptor and/or the progesterone receptor. HR+ breast tumors derive limited benefit from immune checkpoint therapy (ICT), which can be at least partially attributed in part, to low levels of T cell infiltration and low expression of T cell immune checkpoint molecules. In other solid tumors, targeting components of the tumor microenvironment outside of T cells have shown the ability to enhance ICT responses, however, such t

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Mello, Diego C., Marcella M. Cristovao, Kelly C. Saito, Edna T. Kimura, and Cesar Seigi Fuziwara. "Abstract 2964: Chromatin silencing complex EZH2/PRC2 modulates aggressive anaplastic thyroid cancer biology." Cancer Research 82, no. 12_Supplement (2022): 2964. http://dx.doi.org/10.1158/1538-7445.am2022-2964.

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Abstract Introduction: Anaplastic thyroid cancer (ATC) is a rare and lethal undifferentiated thyroid malignancy, with rapid growth, invasion of adjacent tissues and distant metastasis (&gt;50% of cases), leading to survival of ~ 6 months. Understanding the molecular evolution of ATC is a current challenge in thyroid cancer field that may lead to identification of new targets for treatment. In this extent, deregulation of epigenetic regulators and chromatin modifiers may contribute to ATC aggressiveness by altering chromatin state. High levels of EZH2, a component of Polycomb Repressive Com

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Shim, Jenny, Andrew Ho, Hunter C. Jonus, et al. "Abstract 3552: YAP-TEAD2 binding mediates therapy resistance in RAS-driven neuroblastoma." Cancer Research 83, no. 7_Supplement (2023): 3552. http://dx.doi.org/10.1158/1538-7445.am2023-3552.

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Abstract Background/Objectives: Despite intensive multimodal therapy, greater than 50% of children with high-risk neuroblastoma (HR NB) relapse with incurable disease. Next generation sequencing of primary HR NB tumors identified an increase in activating mutations in the RAS/RAF/MAPK pathway. Moreover, gene set enrichment analyses showed a significant decrease in expression of genes suppressed by the Yes-Associated Protein (YAP) at relapse, suggesting increased YAP transcriptional repression. YAP binds with TEAD family transcription factors to regulate gene expression. We have shown that YAP

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