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Dissertations / Theses on the topic 'Gene polymorphism'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Tellier, AureÌlien. "A theory of polymorphism in gene-for-gene interactions." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439932.

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2

Atan, Deniz. "Cytokine gene polymorphism in non-infectious uveitis." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492470.

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Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance t

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3

Sankaran, David. "Cytokine gene polymorphism and kidney transplant outcome." Thesis, University of Manchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488310.

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The pro-inflammatory cytokine TNF -a. and the immunoregulatory cytokine IL-IO have been implicated in acute rejection of kidney allografts. Similarly, the pro-fibrotic cytokine TGF-IJ 1 has been reported to be involved in the development of chronic rejection. It has also been shown that polymorphisms in the TNFA gene promoter (position -308) and in the TGF-IJI gene (at codon 25) correlate with differential production of these cytokines in vitro. Gene polymorphisms in the IL-IO promoter were also identified previously. However, their function had not been determined. Therefore, the initial part

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4

Pandya, Bhavna Kalpesh. "Thiopurine s-methyl transferase gene polymorphism : Clinical correlations." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529233.

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5

Tomeson, D. "Nucleotide excision repair gene polymorphism and skin cancer." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662988.

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The most important environmental risk factor for skin cancer is sunlight exposure. The genetic component is seen in the inherited genodermatoses, such as Xeroderma Pigmentosum (XP), where there is a 1000-fold increased risk of skin cancer. Nucleotide excision repair (NER), the pathway responsible for removal of UV-induced DNA damage, is defective in XP patients. The XPB and XPD helicases are essential components of the NER pathway. Frequent polymorphisms have been reported in NER genes and polymorphisms in ERCC2, ERCC1 and XPF have been investigated for association with various types of cancer

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6

Moskaliuk, I. I., and O. I. Fediv. "Thyrotoxicosis and irritable bowel syndrome: SERT-gene polymorphism." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17104.

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7

Liu, Shuk Ming. "Single nucleotide polymorphism in human microsomal glutathione s-transferase gene and colorectal cancer /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20LIU.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 95-105). Also available in electronic version. Access restricted to campus users.

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8

Raunio, T. (Taina). "Gene polymorphism and systemic inflammatory response in chronic periodontitis." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514292361.

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Abstract In this study, associations between periodontitis expression, serum levels of inflammatory markers and genetic factors were investigated. The periodontal status of 56 subjects with chronic periodontitis, 28 control subjects and 80 subjects with type I diabetes mellitus (DM) was examined. In addition, a reference group (n=178) with genetic but not with periodontal health data was included. The single nucleotide polymorphisms of CD14 -260, IL-6 -174, TNF-α -308, IL-10 -1082, IL-1A -889, IL-1B +3954, and TLR4 +896 were determined using PCR with RFLP or allele-specific primers, and compar

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9

Wiener, Christopher Charles. "Intraspecific 16S ribosomal RNA gene polymorphism in Staphylococcus epidermidis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39895.pdf.

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10

Muhammed, H., Андрій Миколайович Лобода, Андрей Николаевич Лобода, and Andrii Mykolaiovych Loboda. "Gene polymorphism in patients with type 1 diabetes mellitus." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60769.

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Type 1 diabetes mellitus (T1DM) is a common medical and social problem, which frequency increased during last decade. Annual incidence varies from 0.61 cases per 100,000 population in China to 41.4 cases per 100,000 population in Finland. A general amount ill child in Ukraine in 2016 is approximately 8,500. T1DM is a disease with heterogeneous etiology, influenced by environmental factors and prevalent autoimmune susceptibility. Predisposition of the autoimmune pancreatic β-cell destruction has been associated with genetic variations on different chromosomes.

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11

Aramini, Beatrice <1979&gt. "Role of SP-A gene polymorphism in lung transplantation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3634/1/aramini_beatrice_tesi.pdf.

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Lung transplantation is a widely accepted therapeutic option for end stage lung disease. Clinical outcome is yet challenged by primary graft failure responsible for the majority of the early mortality, by chronic allograft dysfunction and chronic rejection accounting for more than 30% of deaths after the third postoperative year. Pulmonary surfactant proteins (SP) A, B, C and D are one of the first host defense mechanisms the lung can mount. SP-A in particular, produced by the type II pneumocytes, is active in the innate and adaptive immune system being an opsonin, but also regulating the macr

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12

Aramini, Beatrice <1979&gt. "Role of SP-A gene polymorphism in lung transplantation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3634/.

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Lung transplantation is a widely accepted therapeutic option for end stage lung disease. Clinical outcome is yet challenged by primary graft failure responsible for the majority of the early mortality, by chronic allograft dysfunction and chronic rejection accounting for more than 30% of deaths after the third postoperative year. Pulmonary surfactant proteins (SP) A, B, C and D are one of the first host defense mechanisms the lung can mount. SP-A in particular, produced by the type II pneumocytes, is active in the innate and adaptive immune system being an opsonin, but also regulating the macr

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13

Smith, Erin N. "Gene-environment interaction in yeast gene expression /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5025.

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14

Cavet, James. "Risk factors for graft-versus-host-disease." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250123.

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15

Riddoch, B. "Selection component analysis of the PGI polymorphism in Sphaeroma rugicauda." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378440.

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16

Schaffer, Marie. "HLA and KIR gene polymorphism in hematopoietic stem cell transplantation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-836-3/.

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17

Tarlow, Joanna Karen. "Interleukin-1 receptor antagonist gene polymorphism in chronic inflammatory diseases." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296761.

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18

Pungliya, Manish S. "Single nucleotide polymorphism analysis in application to fine gene mapping." Digital WPI, 2001. https://digitalcommons.wpi.edu/etd-theses/642.

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Single nucleotide polymorphisms (SNPs) are single base variations among groups of individuals. In order to study their properties in fine gene mapping, I considered their occurrence as transitions and transversions. The aim of the study was to classify each polymorphism depending upon whether it was a transition or transversion and to calculate the proportions of transitions and transversions in the SNP data from the public databases. This ratio was found to be 2.35 for data from the Whitehead Institute for Genome Research database, 2.003 from the Genome Database, and 2.086 from the SNP Consor

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19

Afridi, Sarwat. "Influence de variants génétiques candidats sur des phenotypes liés au paludisme à Plasmodium falciparum et effet fonctionnel du polymorphisme NCR3-412 associés au paludisme." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4037.

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Le paludisme est une cause majeure de morbidité et de mortalité, plus particulièrement en Afrique sub-saharienne. De très nombreuses observations sont en faveur de l'existence de facteurs génétiques contrôlant le devenir de l'infection palustre. Il est très probable que certains variants génétiques de gènes candidats du paludisme affectent la résistance du paludisme à travers leur effet sur la réponse immunitaire acquise. Afin de vérifier cette hypothèse, nous avons étudié, dans une population vivant au Burkina Faso, des variants génétiques de HBB, IL4, IL12B, TNF, LTA, FCGR2A et NCR3 dont l'a

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20

Donati, Mauro. "Gene polymorphisms and related cell markers in periodontitis lesions /." Göteborg : Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, 2009. http://hdl.handle.net/2077/20298.

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21

Montgomery, Stephen. "On computational strategies for regulatory element and regulatory polymorphism detection." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/58.

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Identification of the mechanisms by which genes are regulated in eukaryotes is one of the principal challenges of modern biology. The emergence of genome sequencing has facilitated the marked expansion of experimental and computational approaches designed to address this challenge. Integrating and assessing this information remains a major scientific endeavor that requires new and innovative application of technology. Furthermore, our limited understanding of the mechanisms of gene regulation in eukaryotes has undermined our ability to understand the role of genetics in gene regulation. R

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22

Davidson, Scott. "Investigating human polymorphism density and transcriptional regulation of the galanin gene." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=100111.

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The present study aimed to gain better insights into the distribution of genomic variation, in the form of single nucleotide polymorphisms, within the human genome. Using set theory, the average SNP density of the human genome was found to be 2.6 SNPs per kilobase. This figure decreased with increasing evolutionary depth, i.e. conservation. The conserved exonic, intronic subsets had a lower SNP density than the conserved intergenic subset, suggesting that the conserved exonic and intronic regions are under similar strengths of selective pressure while conserved intergenic regions are under

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23

Maksymyuk, V. V. "Polymorphism N34S of the SPINK1 gene in patients with acute pancreatitis." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19661.

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24

Chadwick, Ian George. "Studies on the angiotensin converting enzyme gene polymorphism and ACE inhibitors." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21136.

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Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism accounts for 47% of the variability in serum ACE concentrations between subjects but its relevance to tissue ACE is unknown. ACE inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in t

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25

Woods, David Richard. "The ACE I/D polymorphism and gene-environment interaction in human performance." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413280.

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26

Schveigert, Diana. "Matrix metalloproteinases gene expression and their polymorphism in breast and prostate cancer." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141230_153210-88818.

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Matrix metalloproteinases (MMP) are a family of proteolytic enzymes; these enzymes participate in tumour angiogenesis, processes of tumour growth and development of metastases. Therefore, it is important to evaluate the changes of expression of these enzymes in cancer patients. The aim of this study – to assess the expression of MMP genes and single nucleotide polymorphism in promoter sequences of MMP genes in breast and prostate cancer and evaluate parameters investigated regarding prognosis. The perspective study included 88 female patients with breast cancer and 82 patients with prostate ca

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27

Yu, Chack-yung. "The gene structure and the polymorphism of the human complement component C4." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:5a8473fb-01c1-43a1-961b-6c23f41c93f4.

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1. The DNA sequence of the human complement C4A gene from a cosmid clone Cos 3A3 was determined and the complete exon-intron structure elucidated. The 5' flanking region of the C4 gene contains three TATA sequences and a transcriptional enhancer core sequence, which are >200 nucleotides (nt) and 60-70 nt upstream from the CAP site, respectively. The gene consists of 42 exons coding for a precursor protein of 1745 residues. The first exon codes for a 51 nt 5' untranslated sequence, a leader peptide of 19 residues, and the N-terminus of the β chain. The β-α and the α-γ chain junctions are encode

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28

Kirkpatrick, Alison. "Cytokine gene polymorphism analysis and HPV typing in low grade cervical lesions." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446468/.

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Persistent high-risk human papillomavirus infection (HPVI) of the uterine cervix is associated with squamous intraepithelial lesions (SIL) and cervical cancer. Low-grade SIL (LSIL) is common but factors determining the outcome are incompletely understood and the management is controversial. The infecting HPV type and the host response to HPVI are thought to be important. Genetic polymorphisms in the regulatory sequences of genes have been identified that are associated with different levels of cytokine expression. These include interieukin 1 alpha (IL-1alpha, 46 base pair VNTR in intron 6), in

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29

Torkko, Kathleen Carroll. "Vitamin D receptor gene polymorphisms and prostate cancer /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Epidemiology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 95-118). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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30

Bekris, Lynn Matthews. "Glutathione related enzyme gene polymorphisms and type 1 diabetes /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8442.

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31

El-Sakka, N. "Polymorphism of the manganese superoxide dismutase gene : relevance to mitochondrial dysfuntion and sepsis." Thesis, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419715.

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32

Dhar, Kalyan K. "Analysis of cyclin D1 gene (CCND1) polymorphism and expression in epithelial ovarian cancer." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344055.

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33

Iftoda, O. M. "Gender aspects of connexin 26 (GJB2) gene polymorphism in children with hearing loss." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19712.

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34

Kmyta, V. "Bcli polymorphism of glucocorticoid receptor gene in patients with bronchial asthma and obesity." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40552.

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Certain investigations showed that genetic factors of bronchial asthma (BA) and obesity overlap each other, this indicates that they have common genetic predisposition. Thus, BA and obesity are associated with the genes, which encode β-adrenergic receptor, insulin-like growth factor, IL-1α, leukotriene A4 hydroxylase, glucocorticoid receptor (GR), uncoupling protein, etc.

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35

Chumakov, V., Олександр Леонідович Ситнік, Александр Леонидович Сытник, Oleksandr Leonidovych Sytnik, and A. Dmitruk. "Polymorphism of gene of IL-8 cytokine in acute pancreatitis complicated with peritonitis." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/63611.

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This study has assessed the possible association of IL-8 (-251А/Т) polymorphism with clinical course of pancreatogenic peritonitis and suggests that the identification of genetic polymorphism of IL-8 (-251A/T) may be informative and serve as an additional criterion to predict both the clinical course and outcome of pancreatogenic peritonitis.<br>Te studium zostało przeprowadzone w celu określenia możliwego związku miedzy genetycznym polimorfem cytokiny IL-8 (-251А/Т), a jego wpływu na warianty klinicznego przebiegu ostrego zapalenia trzustki, skomplikowanego zapaleniem otrzewnej i może d

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36

Kinose, Daisuke. "NOD2 Gene Polymorphism was associated with prevalence and severity in Japanese COPD patients." Kyoto University, 2012. http://hdl.handle.net/2433/152499.

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37

Angelo, Sandro Nunes. "Influencia dos polimorfismos T6235C e A4889G, do gene CYP1A1, e dos haplotipos NAT1*3, NAT1*4 e NAT1*10 do gene NAT1, associados com o metabolismo de carcinogenos, na susceptibilidade ao adenocarcinoma colorretal esporadico." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308618.

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Orientadores: Carmen Silvia Passos Lima, Claudio Saddy Rodrigues Coy<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T04:46:06Z (GMT). No. of bitstreams: 1 Angelo_SandroNunes_M.pdf: 2804773 bytes, checksum: b88b1fbf49effea5eae1bf248bc95389 (MD5) Previous issue date: 2008<br>Resumo: A exposição das células do cólon e do reto a substâncias carcinogênicas está associada ao consumo de alimentos que constituam fonte de substratos, como aminas aromáticas e hidrocarbonetos aromáticos policiclícos. Enzimas como a m

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38

FERREIRA, Jacyra Salucy Antunes. "Polimorfismo do gene MBL2 em pacientes e contatos intradomiciliares de hanseníase e sua associação com classe operacional, formas clínicas e Anti-PGL1 em áreas de risco no município do Recife-PE." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4697.

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Submitted by (edna.saturno@ufrpe.br) on 2016-06-13T14:33:26Z No. of bitstreams: 1 Jacyra Salucy Antunes Ferreira.pdf: 1876152 bytes, checksum: ac08788f02861882b87798086b8b7c71 (MD5)<br>Made available in DSpace on 2016-06-13T14:33:26Z (GMT). No. of bitstreams: 1 Jacyra Salucy Antunes Ferreira.pdf: 1876152 bytes, checksum: ac08788f02861882b87798086b8b7c71 (MD5) Previous issue date: 2014-05-12<br>Despite the economic and social transformations, leprosy remains a public health problem. Pernambuco has 60 % of cases concentrated in the Recife metropolitan area and is responsible for 30% of t

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39

Dai, Yang. "Impact of the CYP3A5 polymorphism on the metabolic disposition of calcineurin inhibitors /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/7935.

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40

Winship, P. R. "Carrier detection and patient studies in haemophilia B." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376959.

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41

Kuo, Alice Yi-Wen. "Genomic and Physiological Differences for Ghrelin and Leptin Receptor in Lines of Chickens Selected for High and Low Body Weight." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/30045.

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Autonomic nervous system (ANS) activity is related to body weight regulation. Based on the hypothesis that Most Obesities kNown Are Low In Sympathetic Activity (MONA LISA), it has been suggested that most obese subjects and animals have low sympathetic nervous system activity. Leptin, leptin receptor, and ghrelin genes influence the ANS regulation of body weight and food intake. The aim of this study was to investigate whether there are differences in leptin, the leptin receptor, or ghrelin regulation between lines of chickens selected for high (HWS) or low body weight (LWS). Intraperitoneal

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42

Chen, Man-Ling, and 陳曼伶. "Association of gout and gene polymorphism." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/27424735477406204309.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>91<br>Gout is not a single disease but a term used to describe a group of metabolic disorders characterized by tissue deposition monosodium urate (MSU) monohydrate crystals from hyperuricaemic body fluids. Major clinical manifestations include gouty arthritis, tophus, gouty nephropathy, and uric acid calaulus in the urinary tract. According to epidemiological and experimental studies, the incidence of gout is higher in men than in women. In addition to life style and eating habits, genetic factors are probably the major cause of the disease, although the exact me

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43

Tsuei, Yuang-Seng, and 崔源生. "Gene Polymorphism in Dural Arteriovenous Fistula." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/c57a89.

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博士<br>中山醫學大學<br>醫學研究所<br>106<br>Dural arteriovenous fistula (DAVF) is a rare but important cerebrovascular disorder in adults. Little is known about the molecular genetic pathogenesis underlying the development of DAVF. The present study was conducted to investigate the associations of gene polymorphisms and DAVF. Using real-time polymerase chain reaction (real-time PCR) genotyping, 7 single-nucleotide polymorphisms (SNPs) of angiogenesis-related genes, including MMP-2 -1306 (rs243865); MMP-9 (rs17576); MMP-9 (rs9509); TIMP-1 (rs4898); TIMP-2 (rs2277698); VEGFA (rs2010963); VEGFA (rs3025039) w

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44

Lu, Cheng-Hsuan, and 呂政弦. "Detection of Caprine Kappa-Casein Gene Polymorphism." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/98621930408771307215.

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碩士<br>國立臺灣大學<br>畜產學研究所<br>89<br>Genetic polymorphism researches are mostly conducted by means of RFLP (restriction fragment length polymorphism) or PCR-RFLP（polymerase chain reaction- restriction fragment length polymorphism）. However, the aforementioned means have certain drawbacks, such as radiative material processing, time-consuming and difficulty of finding appropriate restriction enzyme cutting-site(s). SSCP (single-strand conformation polymorphism) can avoid such problems and utilize DNA or RNA's sequence’s difference which can cause different mobility in non-denature polyacrylamide gel

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45

Liu, Chin Hung, and 劉晉宏. "Genetic Polymorphism of UGT1A1 Gene in Chinese." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/86655124709807661572.

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碩士<br>國立成功大學<br>藥理學研究所<br>87<br>The UGT1A1 is a detoxifying enzyme that catalyzes the formation of glucuronic acid conjugates of several endogenous and exogenous compounds such as bilirubin, steroid hormones and many therapeutic drugs. Differences in the activity of UGT1A1 would possibly cause some toxic or carcinogenic effects. Genetic disorders in the UGT1A1 gene are responsible for both Gilbert''s and Crigler-Najjar syndromes. Gilbert''s syndrome, is a benign form of unconjugated hyperbilirubinemia by mild elevation of serum total the most prevalent ( about 3-10% in Caucasian population stu

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46

"Polymorphisms in gene promoters and their transactivation activities." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074564.

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Briefly, some findings in my research are as follows: (1) The genetic variants of the CA repeats in IGF1 promoter 1 can affect the activity of promoter 1, and the CA repeat showed a suppressive effect on the activity of the promoter 1 of IGF1 gene. EMSA results have shown that the CA repeats could bind to certain nuclear protein. (2) The SNPs T/C (rs5742612) and T/A (rs2288377) can also affect the activity of the promoter 1 in IGF1 gene, and the activity of C-A haplotype is significantly higher than that of T-T haplotype. EMSA results have shown that the SNP T/A (rs2288377) could bind to certa

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47

Jiang, Jie-Ran, and 江介然. "Effect of Promoter Polymorphism of the Angiotensinogen Gene on Gene Expression." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/34537013463340892436.

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碩士<br>國立臺灣大學<br>生理學研究所<br>87<br>Hypertension is still one of the major ten death causes in Taiwan, and is the risk factor of many other chronic diseases. The majority of hypertension is essential hypertension, without known causes. Based upon the research evidence, the essential hypertension is a disease influenced by many genes, and the human angiotensinogen gene is the most outstanding one of the candidate genes. The plasma angiotensinogen concentration was known to be higher in the hypertensive patients than the normotensive persons. The change of 235th amino acid in the mature angiotensino

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48

Lin, Sir-Chen, та 林斯晨. "Association between PPARα Gene Polymorphism and Metabolic Syndrome". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/02513932262038170157.

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碩士<br>臺灣大學<br>臨床醫學研究所<br>96<br>Introduction Characteristics of the metabolic syndrome are abdominal obesity, atherogenic dyslipidemia, raised blood pressure, insulin resistance, prothrombotic and proinflammatory states. Patients with metabolic syndrome are at increased risk for developing diabetes mellitus (DM) and cardiovascular diseases. Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. PPARs are found in liver, heart, liver and skeletal muscle. PPARs are ligand-induced transcription factors that regulate t

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Pan, Ya-Chun, and 潘雅君. "Gadd45b gene expression and polymorphism in Rheumatoid Arthritis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/95350881225061513089.

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碩士<br>高雄醫學大學<br>醫學研究所<br>99<br>Rheumatoid arthritis(RA) is a chronic inflammation disease, its pathogenesis is complex, multifactorial, including genetic, immune disorders, and environmental impacts, the detailed pathogenesis is still unknown. Our research aims to investigate Gadd45b gene expression and gene polymorphism with rheumatoid arthritis correlation. Ninety healthy contols,and 127 patients with RA were enrolled in this study.Total RNA and Genomic DNA of buffy coat cells were extract from peripheral blood mononuclear cells (PBMCs). The Gadd45b gene expression was measured by the method

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Liu, Han-Pang, and 劉漢邦. "Cytochrome P450 2J2 gene G-50T polymorphism and angiotensin-converting enzyme gene insertion/deletion polymorphism in oral cancer and precanceous patients." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/58122063463122709357.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>97<br>Objective： Angiotensin-converting enzyme (ACE) is expressed in a wide range of tissues. It may be involved in various steps of the inflammatory response. Cytochrome P450(CYP)2J2 metabolizes arachidonic acid to epoxyeicosatrienoic acids(EETs). The EET are potent inhibitors of inflammation. We want to investigate the connection among ACE I/D gene polymorphism, CYP2J2 G-50T gene polymorphism , oral cancer patient and oral precancer patient compared with non-oral mucosal lesion subject with betel nut chewing habit control group. We also test the hypothesis that ACE

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