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Dissertations / Theses on the topic 'Gene primers'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ahmad, M. Mursaleen Cheng Jianlin. "MUPrimer a tool for finding allele specific PCR-primers for homologous gene sequences /." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6660.

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Title from PDF of title page (University of Missouri--Columbia, viewed on March 10, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Thesis advisor: Dr. Jianlin Cheng. Includes bibliographical references.

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2

Alonso, Gabriela Caroline. "Avaliação, desenho e padronização de primers para genes de virulência de Candida albicans e sua expressão em isolados clínicos submetidos à terapias antifúngicas /." Araraquara, 2017. http://hdl.handle.net/11449/152919.

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Orientador: Ana Cláudia Pavarina<br>Abstract: Este estudo avaliou longitudinalmente a expressão de genes de virulência de isolados clínicos de Candida albicans de pacientes com candidose oral tratados com Terapia Fotodinâmica Antimicrobiana (aPDT) ou Nistatina (NIS). Inicialmente, a especificidade de primers da literatura e novos primers desenhados para os genes de virulência de C. albicans ALS1, CAP1, CAT1, EFG1, HWP1, LIP3, PLB1, SAP1, SAP4, SOD1, SOD5 e ACT1 (gene de controle) foi avaliada através de análises in silico e in vitro. Para a análise in silico, foi realizada uma busca no Pubmed

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3

Babben, Steve [Verfasser]. "An efficient approach for the development of locus specific primers in wheat and its application in a candidate gene based association study on frost tolerance in wheat (Triticum aestivum L.) / Steve Babben." Halle, 2019. http://d-nb.info/1177798565/34.

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4

Münzner, Ulrike. "Gene fishing in Cataglyphis fortis – Identification of genes inthe desert ant." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20455.

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<p>The desert ant Cataglyphis fortis lives in the Sahara desert where it is exposed to extreme temperatures up to 70° C. In other words, the organism is considered as a thermophile. Until now the genome remains unknown but the fact that C. fortis provides heat stable proteins makes it very interesting in the field of protein studies and maybe even therapeutical research later on. This thesis focuses on trying to find genes that are expressed in C. fortis. Different genes were chosen and capable primers designed. After fishing for the enzyme GAPDH a fragment was found and sequenced. The sequenc

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5

Souza, AlethÃia CarÃzia Baracho de Lima. "Estudos sobre as interaÃÃes das proteÃnas seminais com as cÃlulas espermÃticas e componentes dos diluidores usados na criopreservaÃÃo do sÃmen e sobre marcadores moleculares de parÃmetros do sÃmen em animais de produÃÃo." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12911.

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FundaÃÃo de Amparo Ã Pesquisa do Estado do CearÃ<br>A tese Ã composta por dois capÃtulos. O primeiro capÃtulo inclui o trabalho cujo objetivo foi investigar o potencial uso de pares de transcritos correlativos baseados em microarranjos como marcadores de fertilidade masculina usando a displasia da bainha fibrosa (DFS) como modelo afetado. Atualmente Ã bastante reconhecido que a tecnologia de microarranjos pode ser limitada pelos custos e que a qualidade dos transcritos permanece relativamente desconhecida. Para responder essas questÃes, nÃs analizamos pares de transcritos estÃveis por qPCR com

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6

Mascarenhas, Soraia Andreia Coelho. "Nova abordagem para deteção das subespécies de Photobacterium damselae." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12793.

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Mestrado em Biotecnologia - Biotecnologia Industrial e Ambiental<br>Em todo o mundo, os recursos para pesca encontram-se próximos dos limites de exploração sustentável. A prática de aquacultura é uma atividade que veio ajudar a contornar o esgotamento dos recursos pesqueiros, sendo hoje em dia responsável por contribuir com cerca de metade do fornecimento de peixe para consumo humano mundial. No entanto, a aquacultura é propícia ao aparecimento de surtos de doenças causadas por agentes patogénicos bacterianos. Estes geralmente têm um impacto nefasto nos sistemas de cultivo causando muitas veze

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7

Morley, Gavin W. "Gene hunting in primary osteoarthritis." Thesis, University of Oxford, 2004. https://ora.ox.ac.uk/objects/uuid:1529aa12-2d57-48fd-8cb9-a5bab0291116.

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Osteoarthritis (OA) is a common, disabling disease of the elderly. It is uncommon in individuals under 45 years of age, and prevalence is higher in females than males. OA is characterised by focal cartilage loss accompanied by osteophytes, sclerosis and often some inflammatory response. A significant genetic component to OA has been demonstrated by twin-pair, sibling risk and segregation studies. Our group previously carried out a two-stage genome-wide linkage scan and identified six chromosomal regions as potentially harbouring OA susceptibility genes. The aim of this project was to examine t

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8

Alldinger, Ingo, Dag Dittert, Matthias Peiper, et al. "Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136495.

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Background: Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines. Methods: We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells. Results: Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 down

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9

Alldinger, Ingo, Dag Dittert, Matthias Peiper, et al. "Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer." Karger, 2005. https://tud.qucosa.de/id/qucosa%3A27709.

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Background: Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines. Methods: We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells. Results: Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 down

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10

Munye, M. M. "Towards gene therapy for primary ciliary dyskinesia." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1435816/.

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Primary ciliary dyskinesia is a genetic disorder where patients develop lung disease as they are unable to clear airway infections effectively. There is currently no treatment for the underlying genetic defect. This thesis describes advances towards the development of a gene therapy targeting the airway disease in PCD patients with DNAH5 mutations, the most common cause of PCD. Little work has been done in the field so many challenges remain. DNAH5 is a large gene and the cDNA has not been cloned. In addition PCD models are currently inadequate. Finally, non-viral vectors for airway gene deliv

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11

Gomperts, Miranda. "Identification and characterization of cMG1, a primary response gene." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387172.

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12

Thompson, Denis. "Finding homologous genes with primers designed using evolutionary models." NCSU, 2003. http://www.lib.ncsu.edu/theses/available/etd-10232003-122816/.

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Genes homologous to a set of known, aligned, genes can be found by screening DNA libraries with PCR. PCR primers for such screens are commonly designed via a method described by Sells and Chernoff (1995). This standard design method does not make use of information about the evolutionary relationship between the known genes. The present study investigated the efficacy of using information about evolutionary relationships (inferred from the sequence data) in the design of PCR primers. This study compares the standard primer design method (represented herein by a modified multinomial distributio

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13

Dalgard, Clifton Lee. "Hypoxia-inducible factor hydroxylases are oxygen sensors in the brain /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Dalgard2005.pdf.

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14

Guan, Haoji. "Double-stranded RNA induced gene silencing of neuropeptide genes in sand shrimp, Metapenaeus ensis and development of crustacean primary cell culture /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36893626.

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15

Hands, Rebecca. "Analysis of Gene Expression in Primary and Metastatic Colorectal Cancers." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518256.

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16

Wozniak, Amanda Victrix Allen. "A systematic and extensible approach to DNA primer design for whole gene synthesis." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/37059.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.<br>Includes bibliographical references (leaves 93-96).<br>The future of synthetic biology research hinges upon the development of accurate and inexpensive whole gene synthesis technologies. Recent advances in the purification of solid-phase manufactured oligonucleotides make it possible to manufacture whole genes by polymerase chain reaction methods. Yet, despite the improvement in laboratory methods, whole gene synthesis is not rapidly progressing because most gene design softw

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17

Silva, Filipe. "Segregation analysis and candidate gene-screening in primary open-angle glaucoma." Thesis, St George's, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517189.

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18

Choi, Hye Won. "Differential regulation of PTH-induced primary response gene expression in osteoblasts." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1905636821&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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19

Schröder, Adrian [Verfasser]. "Inference of gene-regulatory networks in primary human hepatocytes / Adrian Schröder." München : Verlag Dr. Hut, 2011. http://d-nb.info/1018982930/34.

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20

Nicholson, Thomas Peter. "Design and development of oligonucleotide probes for novel fungal polyketide synthase genes." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322607.

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21

Marucci, Suzana Cristina [UNESP]. "Seleção e caracterização de novos genes vip3A: genes inseticidas de segunda geração de Bacillus thuringiensis." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92703.

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Made available in DSpace on 2014-06-11T19:26:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-03Bitstream added on 2014-06-13T20:14:46Z : No. of bitstreams: 1 marucci_sc_me_jabo_parcial.pdf: 42548 bytes, checksum: 705ccf6a74fac7e11f4cb25dc8fb9403 (MD5) Bitstreams deleted on 2015-01-16T10:37:51Z: marucci_sc_me_jabo_parcial.pdf,Bitstream added on 2015-01-16T10:38:35Z : No. of bitstreams: 1 000638549.pdf: 1096070 bytes, checksum: 93634385c53868612602ba315f79ea43 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado d

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22

Kakal, Juzer. "Transcriptional regulation of the CD127 gene in primary human CD8 T-cells." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28090.

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Factors regulating expression of the IL-7 receptor throughout the CD8 T-cell life-span have not been fully characterized but IL-7 has been shown to down regulate the IL-7 receptor alpha-chain (CD127) at the cell surface. Here we show that IL-7 induced a decline in the level of total CD127 transcripts in CD8 T-cells. Also, IL-7 had no effect on CD127 mRNA stability, or alternative splicing. We also find that down regulation of CD127 by IL-7 requires de novo transcript and protein synthesis. Reporter assay analysis of the CD127 promoter showed that sequences up to 3kb upstream of the TATA box ar

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23

Tedford, Nathan C. "Quantitative analysis of non-viral gene therapy in primary liver culture systems." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39914.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references (p. 161-172).<br>Gene therapy has the potential to cure thousands of diseases caused by genetic abnormalities, provide novel combination therapies for cancers and viral infections, and offer a new and effective platform for next generation vaccines. However, after more than three decades of research and development efforts, clinical success has yet to be realized. Successful delivery of DNA is a crucial first step in attaining safe and effective gene therapeutic

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24

Donaldson, Lucy F. "The primary afferent nociceptor and neuropeptide gene expression : importance in experimental arthritis." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20937.

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In these studies, the primary afferent neuronal response to peripheral inflammation with respect to neuropeptide mRNA expression, and the role of the primary afferent and its neuropeptides in the spread of arthritis have been examined. The regulation of neuropeptide genes in DRG during inflammation is not well understood. Blockage of the increase in primary afferent spontaneous activity known to be observed within hours of the onset of inflammation using local anaesthetic prevented the increase in PPT and CGRP mRNA seen in DRG 8 hours after adjuvant injection. While endogenous glucocorticoids

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25

Wilczynska, Katarzyna Marta. "Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation." VCU Scholars Compass, 2008. http://hdl.handle.net/10156/1772.

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26

Hamid, Colleen G. "Identification of anti-beta₂ glycoprotein I auto-antibody regulated gene targets in the primary antiphospholipid syndrome using gene microarray analysis." Thesis, University of Wolverhampton, 2007. http://hdl.handle.net/2436/14407.

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Anti-Beta2-Glycoprotein I antibodies (anti-b2GPI) are strongly associated with thrombosis in patients with primary antiphospholipid syndrome (PAPS). Anti-b2GPI activate endothelial cells (EC) resulting in a pro-thrombotic and pro-inflammatory phenotype. In order to characterise EC gene regulation in response to anti-b2GPI, early global gene expression was assessed in human umbilical vein endothelial cells (HUVEC) in response to affinity purified anti-b2GPI. Sera were collected from patients with PAPS and IgG was purified using HiTrap Protein G Sepharose columns. Polyclonal anti-b2GPI were prep

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27

Rocha, Danilo Jobim Passos Gil Da. "DESENHO E VALIDAÇÃO DE UM CONJUNTO DE PRIMERS UNIVERSAIS BACTERIANOS PARA NORMALIZAÇÃO DE ENSAIOS DE PCR QUANTITATIVA EM TEMPO REAL." Instituto de Ciências da Saúde, 2017. http://repositorio.ufba.br/ri/handle/ri/25288.

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Submitted by Hiolanda Rêgo (hiolandarego@gmail.com) on 2018-02-05T14:14:00Z No. of bitstreams: 1 Dissertação_ICS_ ROCHA, D. J. P. G..pdf: 4034030 bytes, checksum: 7085be9f2fda81bc8248196d4b4e6988 (MD5)<br>Made available in DSpace on 2018-02-05T14:14:00Z (GMT). No. of bitstreams: 1 Dissertação_ICS_ ROCHA, D. J. P. G..pdf: 4034030 bytes, checksum: 7085be9f2fda81bc8248196d4b4e6988 (MD5)<br>CNPQ<br>O método mais comum de normalização em ensaios de quantificação relativa da expressão gênica por PCR quantitativa em tempo real (qPCR) faz uso de um gene de referência, que deve manter sua expressão

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ORRU', ROBERTO. "Sequenziamento e Analisi Molecolare di Varianti Alleliche del Gene PRB1." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266626.

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The aim of this work was the molecular characterization of gene PRB1 in three subjects with different salivary proteome profile. The PRB1 gene encodes a member of the heterogeneous family of Basic Proline rich Proteins (PRB), produced by the parotid gland and secreted in human saliva. The protein polymorphism resulting from post-translational modifications of the pre-protein PRB1, are further complicated by the gene allelic variants. Those variants involves the third exon of the gene, and are related to the presence or absence of a tandem repeat sequence 183 bp long. That tandem repeat may ori

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29

Ugbogu, Eziuche Amadike. "The PRS gene family links primary metabolism and cell signalling in Saccharomyces cerevisiae." Thesis, Heriot-Watt University, 2014. http://hdl.handle.net/10399/2948.

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The products of the five-membered PRS gene family in S. cerevisiae exist as three entities, Prs1/Prs3, Prs2/Prs5 and Prs4/Prs5, each capable of supporting cell viability. The signal generated from an integrated GFP-Prs1 construct is dependent on the presence of Prs3. Prs1 not only interacts with Prs3 but also with Slt2, the MAPK of the Cell Wall Integrity (CWI) pathway as shown by co-immunoprecipitation and confirming previous Y2H studies that the central region of Prs1, NHR1-1, is essential for the interaction with the CWI pathway. Point mutations in PRS1 corresponding to missense mutations a

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30

Machado, Rajiv David. "The molecular cloning and characterisation of the gene mutated in primary pulmonary hypertension." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/30336.

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Primary pulmonary hypertension (PPH) is a frequently lethal disease, of unknown aetiology. The disorder is characterised by an obliteration of small pulmonary arteries that generates a sustained elevation of pulmonary vascular resistance, leading to progressive right-heart failure. Among the estimated 6-10 % of cases with a family history of disease, the PPH gene segregates in an autosomal dominant manner and acts with substantially reduced penetrance. A positional cloning strategy was employed to isolate the causative gene. Initially, novel recombination events were identified in affected ind

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31

Coiro, Pierluca [Verfasser]. "Plasticity-related gene 5 induces spine formation in immature primary neurons / Pierluca Coiro." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025355571/34.

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32

Sotoodehnejadnematalahi, Fattah. "Studies on regulation of versican gene expression by hypoxia in primary human macrophages." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10304.

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Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a number of hypoxia-inducible genes. The extracellular matrix glycoprotein versican has recently been identified as one such gene, but the mechanisms responsible for hypoxic induction are not well characterised. Here, hypoxic up-regulation of versican was investigated in primary human monocyte-derived macrophages. Flow cytometry of isolated peripheral blood mononuclear cells demonstrated a three-fold increase in versican protein in macrophages after 5 days incubation in hypoxia. Subset a

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33

Wu, Jiakai. "Primary rat hepatocyte isolation and culture regulates the SREBP/SREBP target gene profile." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491482.

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The major limitation of using primary hepatocytes is the rapid dedifferentiation of hepatocytes during isolation and culture, whereby most of the liver-specific functions are lost. Despite the many efforts that have been made to optimize the culture condition, current primary cultured hepatocyte preparations still only retain partial hepatocyte phenotype observed in liver in vivo. To further optimize primary hepatocytes it is essential to understand the key factors that underlie the dedifferentiation process during primary hepatocyte culture. Up or down-regulation of key transcription factors

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34

Lawler, Polly Anne. "Neurotrophic factor regulation of gene expression in primary sensory neurons of the mouse." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/56171/.

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In this study, the expression of several sensory neuron specific/predominant genes, and the effects of neurotrophic factors upon them were studied in embryonic, postnatal and adult mouse sensory neurons. In the embryonic mouse, NGF/TrkA signalling was shown to be essential for the expression of mRNAs encoding substance P and the sodium channels Navl.8 and Navl.9 in DRG and trigeminal ganglia. Differential regulation of the two isoforms of calcitonin gene related peptide (CGRP) mRNA was apparent in the DRG with a requirement of NGF/TrkA signalling for expression of a, but not p CGRP. This was n

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Al-Ali, Shereen Jawad Kadhim. "Identification of whole-blood gene expression signature in primary Sjögren's syndrome-associated lymphoma." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3507.

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Primary Sjögren’s syndrome (pSS) is an autoimmune disease of the exocrine glands. The syndrome is characterized by many systemic features, including a markedly increased risk of lymphoma development. PSS-associated lymphoma was first reported in 1963, however, the mechanisms and the risk factors of lymphoma development in pSS patients remain incompletely understood. The aim of my project is to identify a whole-blood gene expression signature in pSS-associated lymphoma. To achieve this goal, I first evaluated the effect of the depletion of the abundant globin mRNA in whole-blood samples on micr

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MASCARO, MARTINA. "Ruolo di TRIM18, gene che causa la sindrome di Opitz, nel controllo della ciliogenesi attraverso l'autofagia." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996095.

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TRIM18/MID1 è una E3-Ubiquitina ligasi appartenente alla famiglia di proteine TRIM che si localizza sui microtubuli. Le mutazioni con perdita di funzione nel gene MID1 sono state associate alla forma legata all'X della sindrome di Opitz, una malattia genetica caratterizzata da difetti nello sviluppo della linea mediana ventrale. All'interno della cellula, MID1 esiste come un complesso macromolecolare microtubulare, costituito da diversi interattori non tutti ancora identificati. Tra questi, α4 è una delle subunità regolatorie della proteina fosfatasi 2A (PP2A). È stato riportato che MID1 riduc

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Winterbottom, Emily Frances. "The Function of Gsx genes in Xenopus primary neurogenesis." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507495.

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Al-Khalili, Lubna. "Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-866-1/.

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Rezaie-Jami, Tayebeh. "Molecular determination of low tension primary open angle glaucoma gene (GLCIE on 10p15-10p14)." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402449.

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40

Von, Schnakenburg Claus Christian. "Molecular analysis of the AGXT gene and linkage studies in primary hyperoxaluria type 1." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299831.

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FOEGER, C. C. "A PRIMEIRA PESSOA DO PLURAL EM SANTA LEOLDINA/ES." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/3774.

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Made available in DSpace on 2016-08-29T15:08:57Z (GMT). No. of bitstreams: 1 tese_7701_Dissertação_A primeira pessoa do plural do português falado em Santa Leopoldina(ES)_Camila Foeger20151013-110324.pdf: 5806388 bytes, checksum: 81f06a6e4a4b9831667fb4b3f1346bc8 (MD5) Previous issue date: 2014-05-13<br>O presente trabalho objetiva descrever e analisar a alternância pronominal de primeira pessoa do plural e a concordância verbal com o pronome nós na fala dos moradores da zona rural de Santa Leopoldina. Objetiva também estabelecer uma comparação entre o comportamento linguístico dos leopoldine

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To, Kwok-kuen, and 杜國權. "A study of variation theory to enhance students' genre awareness and learning of genre features." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/212616.

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Reading is an important capability to assist in learning. When students are promoted to higher levels at primary school, they have to read more informative texts instead of narrative texts. A number of studies have indicated that many primary school students have difficulty comprehending informative texts. The ways in which teachers structure lesson content and students experience the lesson are important in helping students understand informative texts in terms of genres and genre features. To help students take on the challenges arising from reading informative texts, teachers play a vita

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Kim, Soo Hyun. "Gene therapy demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial ALS." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164829314.

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CHIRIACO, MARIA. "Molecular and biological aspects of primary immunodeficiency." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1126.

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Le immunodeficienze primitive (PID) costituiscono un gruppo eterogeneo di disordini genetici causati da alterazioni delle varie componenti della risposta immune innata ed adattiva. Più di 120 geni sono stati identificati come responsabili delle oltre 150 differenti forme PID. L’eterogeneità genetica e del fenotipo clinico, quest’ultimo caratterizzato da un’alta suscettibilità alle infezioni spesso associata a manifestazioni allergiche, linfo-proliferative ed autoimmuni, rende le immunodeficienze un ottimo modello per lo studio dei meccanismi che regolano lo sviluppo e la funzione del sistem

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Varandas, Edna Soraia Gregório Ribeiro Varandas. "Low-dose effects of Bisphenol A on human primary vascular endothelial cells and colon cancer cells." Doctoral thesis, ISA/UL, 2014. http://hdl.handle.net/10400.5/7338.

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Doutoramento em Biologia - Instituto Superior de Agronomia<br>Bisphenol A (BPA) is an extensively utilized endocrine disruptor for which human exposure is considered generalized through ingestion. Information regarding BPA effects on vascular and digestive tract tissues is scarce. Therefore, in this work primary Human Umbilical Vein Endothelial Cells (HUVEC) and human colon adenocarcinona cell line HT29 were used to evaluate BPA effects at two distinct low-dose concentrations relevant in terms of human health risk assessment. BPA differentially affects the cell types studied, with more

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Ahram, Dina. "The characterization of clinical, genetic and molecular aspects of primary angle closure glaucoma in a canine genetic model." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1283.

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Primary angle closure glaucoma (PACG) is a chronic optic neuropathy that results in retinal ganglion cell (RGC) degeneration, cupping of the optic nerve head (ONH) and subsequent loss of vision. In humans, PACG occurs as a result of a plateau iris or more commonly, a pupillary block. Increased Intraocular pressure and reduced axial length are some of the predisposing factors to PACG. The condition occurs in several breeds of dogs and the prognosis for affected animals is typically poor. Unlike PACG in humans, the mechanism of PACG in canines involves the gradual collapse of the ciliary cleft w

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Breschi, Alessandra 1988. "Gene expression variation and constraint across organs and species." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/523546.

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Mice are the premier model organisms to study human biology and disease, but there is still debate about the extent to which molecular mechanisms are conserved between human and mouse. With the advance of next-generation sequencing technologies, comparative transcriptomics can be carried out at unprecedented resolution. In this thesis we confirm findings that human and mouse transcriptomes are globally conserved and we identify and characterize the properties of a core set of genes with constrained expression between the two species. Additionally, we show that clustering of gene expression acr

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Andreu, Cervera Abraham. "Role of the ciliopathy gene Ftm/Rpgrip1l and primary cilia in forebrain patterning and morphogenesis." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS223.

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Les cils primaires sont essentiels au développement du système nerveux central. Chez la souris, ils jouent un rôle essentiel dans l’organisation de la moelle épinière et du télencéphale via la régulation de la signalisation Hedgehog/Gli. Cependant, malgré la perturbation fréquente de cette voie de signalisation dans les malformations du cerveau antérieur chez l'homme, le rôle des cils primaires dans la morphogenèse du cerveau antérieur a été peu étudié en dehors du télencéphale. Pendant mon doctorat, j’ai étudié le développement du diencéphale, de l’hypothalamus et des yeux chez des souris mut

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Bianco, André de Macedo. "Expressão de CXCR7 e CXCR4 em em astrocitomas iniltrativos em relação ao tecido cerebral não neoplásico e sua interação com HIF1alfa e IDH1." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-01112013-122908/.

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Introdução: Existem dados suficientes disponíveis demonstrando a importância da quimiocina CXCL12 e seu receptor CXCR4 na progressão tumoral e angiogênese dos gliomas. O CXCR4 é regulado positivamente pelo HIF1alfa. Recentemente um novo receptor com maior afinidade à CXCL12 foi identificado, o receptor órfão RDC1, agora denominado CXCR7. O objetivo deste estudo é investigar a expressão de mRNA CXCR7 em tecidos astrocitomas difusos e avaliar suas interações com expressão CXCR4 e HIF1alfa, bem como analisar sua relação com mutação do IDH1. Métodos: A expressão do CXCR7, CXCR4, IDH1 e HIF1alfa fo

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Szvetko, Attila Laszlo. "Gene Expression and Variation in Multiple Sclerosis." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366285.

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Neurological diseases are complex and difficult diseases to study. Although new approaches and therapies have been developed for other disorders such as Alzheimer’s, Epilepsy, and Parkinson’s disease, Multiple Sclerosis (MS) still remains seemingly inexorable. MS is the archetypal complex disease; it is a paradigm of debilitating neuropathology. Discounting trauma, MS is the most common chronic neurological condition resulting in disability affecting young adults. In its typical form it primarily affects the brain, spinal cord, and optic nerves and is characterised by lesions in the central ne

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