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Dissertations / Theses on the topic 'Gene regulation and development'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Losa, Llabata Marta. "Gene regulation in embryonic development." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/gene-regulation-in-embryonic-development(8a9efb79-1ca9-409e-89b9-9d66213e593f).html.

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Branchial arches (BAs) are a series of transient structures that develop on the ventro-lateral surface of the head in vertebrate embryos. BAs initially appear as a series of similar segments; as development proceeds each BA will contribute to different structures. Here, it was investigated the transcriptional mechanisms that instruct the different fates of the BAs in development. Initially, each BA contains a blood vessel, known as aortic arch (AA) artery, that connects the dorsal aorta with the heart. Remodelling of the AAs is crucial to form the adult heart circulation. This process leads to

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2

Chen, Di. "Regulatory pathways controlling larval development in caenorhabditis elegans." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144405.

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3

Ma, Wenqian. "Dlx Gene Regulation of Zebrafish GABAergic Interneuron Development." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19970.

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Abstract The Dlx genes play an important role in the differentiation and migration of gamma-aminobutyric acid (GABA) interneurons of mice. GABAergic interneurons are born in the proliferative zones of the ventral telencephalon and migrate to the cortex early during mouse development. Single Dlx mutant mice show only subtle phenotypes. However, the migration of immature interneurons is blocked in the ventral telencephalon of Dlx1/Dlx2 double mutant mice leading to reduction of GABAergic interneurons in the cortex. Also, Dlx5/Dlx6 expression is almost entirely absent in the forebrain, most proba

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4

Stanworth, Simon J. "The regulation of globin gene expression during development." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260861.

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5

Outram, Susan Virginia. "Regulation of gene expression during T cell development." Thesis, Open University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336801.

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6

Almeida, Tânia Raquel Domingues. "Molecular regulation of cork development: the QsMYB1 gene." Doctoral thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12256.

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Doutoramento em Biologia<br>Cork is a natural and renewable material obtained as a sustainable product from cork oak (Quercus suber L.) during the tree’s life. Cork formation is a secondary growth derived process resulting from the activity of cork cambium. However, despite its economic importance, only very limited knowledge is available about the molecular mechanisms underlying the regulation of cork biosynthesis and differentiation. The work of this PhD thesis was focused on the characterization of an R2R3-MYB transcription factor, the QsMYB1, previously identified as being putatively invol

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7

Weicksel, Steven E. "hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/692.

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Hox genes encode a conserved family of homeodomain containing transcription factors essential for metazoan development. The establishment of overlapping Hox expression domains specifies tissue identities along the anterior-posterior axis during early embryogenesis and is regulated by chromatin architecture and retinoic acid (RA). Here we present the role nucleosome positioning plays in hox activation during embryogenesis. Using four stages of early embryo development, we map nucleosome positions at 37 zebrafish hox promoters. We find nucleosome arrangement to be progressive, taking place over

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8

Weicksel, Steven E. "hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/692.

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Hox genes encode a conserved family of homeodomain containing transcription factors essential for metazoan development. The establishment of overlapping Hox expression domains specifies tissue identities along the anterior-posterior axis during early embryogenesis and is regulated by chromatin architecture and retinoic acid (RA). Here we present the role nucleosome positioning plays in hox activation during embryogenesis. Using four stages of early embryo development, we map nucleosome positions at 37 zebrafish hox promoters. We find nucleosome arrangement to be progressive, taking place over

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9

Zogopoulos, George. "Regulation of growth hormone receptor gene expression during development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0020/NQ44648.pdf.

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10

Petyim, Somsim. "Gene regulation during development of human primordial germ cells." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665476.

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A critical event during embryonic development is the segregation of the germ line from the soma. The germ line founders, or primordial germ cells (PO C), are the precursors of the gametes, which enable the transmission of the genetic material to future generations. In rodents, the PGC precursors are segregated from somatic lineages before the start of gastrulation. In several model organisms segregation of the germ line is accomplished by maternally inherited transcriptional repressors contained in the egg's germ plasm. In mammals, PGC specification is regulated by epigenesis, a mechanism by w

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11

Gadsby, Lisa Marie. "The regulation of carotenoid gene expression during tomato development." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342026.

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12

Neal, Katherine Alison. "Cell signalling and gene regulation in early Xenopus development." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314175.

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13

Greaves, Erin. "The regulation of Ciz1 gene expression during mouse development." Thesis, University of Leeds, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508997.

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14

Ellerström, Catharina. "Gene expression during hard tissue formation /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3137-2/.

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15

Jones, Lynn Marie. "Transcriptional regulation of the Drosophila cyclin E gene during development /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phj7771.pdf.

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16

Zhan, Song. "A development gene regulation network model for Electronic Circuit design." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516396.

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17

Ren, Hui. "REGULATION OF HEPATIC GENE EXPRESSION DURING LIVER DEVELOPMENT AND DISEASE." UKnowledge, 2012. http://uknowledge.uky.edu/microbio_etds/6.

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My first project was to investigate the role of Hepatocyte Nuclear Factor 1 (HNF1) and Nuclear Factor I (NFI) on alpha-fetoprotein (AFP) promoter activity during liver development. AFP is highly expressed in the fetal liver, silenced at birth, and remains at very low levels in the adult liver. A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). The -120 region harbors overlapping binding sites for HNF1 and NFI. While it has been shown that the GA substitution increas

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18

Richmond, Laura. "Development of engineered CRISPR transcription factors for programmable gene regulation." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30942/.

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19

Laurette, Patrick. "Epigenetic regulation of gene expression during melanocyte and melanoma development." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ049/document.

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Le mélanome est un cancer très agressif en raison de sa capacité rapide à former des métastases et de développer une résistance aux traitements existants. MITF (Micropthalmia-associated Transcription Factor) est un facteur de transcription clé à toutes les étapes de développement du lignage mélanocytaire et dans la physiopathologie du mélanome. Afin de comprendre les mécanismes impliqués dans la régulation de l’activité et de la stabilité de MITF, nous avons identifié ses partenaires protéiques parmi lesquels figurent de nombreuses sous-unités des complexes de remodelage de la chromatine ATP-d

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20

Yin, Yizhong. "Molecular mechanism of glycogen phosphorylase gene regulation during Dictyostelium development." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/45587.

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Development of multicellular organisms is one of the most fundamental but least understood biological processes. Due to its simple life cycle, the lower eukaryote Dictyostelium has been used as a model system to study several basic biological problems, such as cell differentiation, cell motility, cell adhesion, signal transduction, and especially gene regulation. Glycogen phosphorylase is the enzyme that initiates one of the key biochemical pathways, glycogen degradation, during Dictyostelium discoideum development. Two forms of glycogen phosphorylase, gpl and gp2, exist in D. discoideum with

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21

Huang, Chen. "Regulation of miR-184 gene expression in early Drosophila development." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/121451.

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Biology<br>M.S.<br>In Drosophila melanogaster, the transcription factor Dorsal initiates dorsal-ventral (DV) patterning in the early embryo by activating or repressing genes, such as the transcription factors Twist and Snail, along the DV axis. Previous studies have shown that the microRNA gene miR-184 in the ventral portion of the embryos (the prospective mesoderm) at the early stages of Drosophila embryogenesis. In order to identify the tissue-specific enhancer that regulates miR-184 expression in the mesoderm, we generated transgenic fly lines and observed the expression of a reporter gene

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22

Wang, Yan. "The Role of the Homeobox Gene ATHB16 in Development Regulation in Arabidopsis thaliana." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4983-2/.

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23

Sohlberg, Joel. "Regulation of plant development by the SHI-family of transcriptional regulators /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200608.pdf.

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24

Hughes, Thomas. "The genetic regulation of Kranz anatomy in maize." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:86184e64-c7bb-43e9-9320-0ebbb2793ea8.

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The C<sub>4</sub> photosynthetic pathway acts to concentrate CO<sub>2</sub> around the enzyme Ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco), ensuring that it catalyses a carboxylation rather than oxygenation reaction, which in turn suppresses photorespiration. In nearly all cases C<sub>4</sub> photosynthesis is underpinned by characteristic Kranz anatomy, with concentric wreaths of bundle sheath (BS) and mesophyll (M) cells surrounding closely spaced veins. The increased yields associated with the C<sub>4</sub> pathway have lead to the suggestion that C<sub>3</sub> crops such as ri

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25

Crippen, Craig A. "Retinoic acid-independent regulation of RARß2 gene expression during cardiac development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq26312.pdf.

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26

Pun, Jason. "The regulation of expression of the cbpA gene during Dictyostelium development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39222.pdf.

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27

Dahlberg, Olle. "Gene regulation during development by chromatin and the Super Elongation Complex." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-103066.

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Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. Transcriptional control involves Pol II recruitment as well as transcriptional elongation. Recent genome-wide studies shows that recruitment of Pol II is often followed by an intermediate step where Pol II is halted in a promoter-proximal paused configuration. The release of Po

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28

Ma, Xiaoli [Verfasser]. "Spatiotemporal Regulation of Gene Expression during Plant Meristem Development / Xiaoli Ma." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1239644507/34.

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29

Hertweck, Arnulf. "Dicer-dependent regulation of gene expression and development in T lymphocytes." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501208.

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30

Wong, Ming-Ching. "Regulation of twist activity during mesoderm and somatic muscle development in drosophila /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1642921011&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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31

Wessel, Karen. "Expression, function and regulation of the Him gene during Drosophila heart development." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/48914/.

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I have analysed the regulation and function of the Him gene to gain new insights into Drosophila heart development and its controlling factors. My results show that Him is important during the early specification of pericardial cells and cardioblasts. Loss of Him leads to a reduced number in both of these cell types by the end of embryogenesis. Over-expression of Him throughout the heart results in supernumerary pericardial cells. Him is expressed in all embryonic pericardial cells from embryonic stage 12 to approximately stage 15. I have identified an enhancer fragment that reproduces this ex

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32

Clinkenbeard, Erica Leigh. "INSIGHTS INTO HEPATIC ALPHA-FETOPROTEIN GENE REGULATION DURING LIVER DEVELOPMENT AND DISEASE." UKnowledge, 2012. http://uknowledge.uky.edu/microbio_etds/1.

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The liver is an essential organ for cholesterol homeostasis. If this process becomes dysregulated, cardiovascular disease (CVD) develops. Zinc-fingers and homeoboxes 2 (Zhx2) as an important hepatic gene regulator and contributes to CVD. BALB/cJ mice, with mutant Zhx2 allele, have fewer atherosclerotic plaques compared to other strains on a high fat diet. In my dissertation, I focused on the liver phenotype in BALB/cJ mice on a high-fat diet and found increased liver damage compared to wild-type Zhx2 mice. These data indicates that reduced Zhx2 in the liver leads to CVD resistance, but increas

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33

Gaddipati, Sanyasi Rao. "Development of molecular tools to study virulence gene regulation in Listeria monocytogenes." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445680.

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34

Jirajaroenrat, Kanya. "Development of ribozyme technology for gene down-regulation in farm animal species." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408887.

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35

Richards, A. J. "Regulation of cell type specific gene expression during development of Dictyostelium discoideum." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384706.

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36

Edelweiss, Villava Robles Casandra. "The molecular regulation of Hox gene RNA processing during Drosophila embryonic development." Thesis, University of Sussex, 2015. http://sro.sussex.ac.uk/id/eprint/52959/.

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The Hox genes encode a family of developmental regulators that are essential for the normal patterning of the animal body axis. Their correct expression is controlled by a number of mechanisms including RNA processing, a molecular system that allows the formation of alternative mRNAs from a single gene. Previous work in the Alonso Lab has demonstrated that RNA processing of the Drosophila Hox gene Ultrabithorax (Ubx) by means of alternative splicing and alternative polyadenylation plays an important role during Drosophila development, but the mechanisms underlying these regulatory processes ar

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37

Sagaram, Uma Shankar. "Molecular characterization of genes regulating fumonisin biosynthesis and development in maize pathogen fusarium verticilliodes." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1361.

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38

Schneider, Katelin A. "Molecular Characterization and Endocrine Regulation of Development in Tadpoles of Xenopus Tropicalis." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511858507180701.

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39

Radke, Joshua Byran. "Transcriptional control of Toxoplasma development." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5108.

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Toxoplasma gondii is an obligate intracellular protozoan parasite of animals and man. The asexual life cycle of Toxoplasma involves three very distinct, but tightly coordinated developmental stages. In nature, the sporozoite (contained within an oocyst) and bradyzoite (contained within a tissue cyst) initiate infection of the intermediate host, followed by rapid differentiation into the actively replicating tachyzoite. When countered by an effective host response, the tachyzoite differentiates back into the latent bradyzoite and this unique ability of Toxoplasma to interconvert between the rep

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40

Shi, Huilin. "The common basis of sympathetic nervous system and neuroblastoma development." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1244058100.

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Thesis (Ph. D.)--University of Toledo, 2009.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences (Cancer Biology)." Title at OhioLINK ETD site: Investigation of common bases of sympathetic nervous system and neuroblastoma development. Title from title page of PDF document. Includes bibliographical references (p. 72-75, 119-125, 152-192).

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41

Nguyen, Ann Luu. "Transcriptional regulation of FRUITFULL a MADS-box gene involved in Arabidopsis fruit development /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1455899.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed March 25, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 45-47).

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42

Salmon, Nicholas Alan. "Oocyte regulation of granulosa cell gene expression during ovarian follicle development in mice." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410899.

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43

Salisbury, Rachel. "Gene expression and cell cycle regulation in human pancreas development and congenital hyperinsulinism." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/gene-expression-and-cell-cycle-regulation-in-human-pancreas-development-and-congenital-hyperinsulinism(e9f58d6a-aba4-4179-a683-6d2380a55397).html.

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The dynamics of β-cell mass are at the focus of an extensive international effort to develop β-cell replacement therapies for type 1 diabetes. During normal fetal development endocrine cells emerge from a pool of PDX1+/SOX9+ multipotent progenitors that transiently express the proendocrine gene NGN3. These cells become hormone-positive and are seen to bud from the ductal structures and aggregate into islet clusters. Congenital hyperinsulinism in its diffuse form (CHI-D) is characterised by an increase in hormone-positive cells associated with ducts and diffuse patterns of insulin expression. C

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44

Crippen, Craig Alexander. "Retinoic acid-independent regulation of RAR(beta)2 gene expression during cardiac development." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/9528.

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RAR$\beta$ has been shown to be expressed in the developing heart at the 8 somite stage. Differentiation of EC cells with DMSO produces a mixture of embryonic cardiac, skeletal, endodermal and other mesodermal derivatives. The RAR$\beta$-2 isoform is predominantly expressed in the differentiated cardiac muscle cells. RT-PCR with isoform specific primers has been used to identify RAR$\beta$-2 as the predominant isoform. These results show, that like RA-treated EC cells, expression of the RAR$\beta$-2 isoform in DMSO differentiated P19 cells predominates. Stable transformants of the RARE$\beta$-

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45

Edey, Caitlin. "Retinoid-mediated Regulation of NR6A1, Prickle1 and Ror2 During Development of the Mouse Embryo." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23609.

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Vitamin A and its derivatives, collectively termed retinoids, are essential for proper growth and development as well as maintenance of homeostasis in the adult. Retinoic acid (RA), the major biologically active vitamin A metabolite, is well characterized for its crucial roles in gene activation during embryogenesis. Our lab had previously performed a microarray analysis to identify genes induced by exogenous RA in the tailbud of early mouse embryos. Three genes were chosen from the microarray results for further investigation; Germ Cell Nuclear Factor (GCNF/NR6A1), Prickle1 (Pk1) and Ror2, th

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46

Le, May Melanie. "Role of the Retinoid X Receptors in Skeletal Muscle Development." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20036.

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Pluripotent stem cells have the capacity to develop into different cell lineages and can be manipulated into certain cell types through the use of small molecule inducers. Retinoic acid (RA) signaling through retinoic acid receptors (RAR) and retinoid X receptors (RXR) has the ability to direct lineage determination but has yielded disappointing results in promoting skeletal myogenesis in embryonic stem (ES) cells. RXR is crucial in embryonic development although it is generally considered to act as a silent partner for other nuclear receptors such as RAR. Our findings demonstrate that rexi

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47

Sun, Xin, Swetansu K. Hota, Yu-Qing Zhou, et al. "Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function." COMPANY OF BIOLOGISTS LTD, 2018. http://hdl.handle.net/10150/627080.

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How chromatin-remodeling complexes modulate gene networks to control organ-specific properties is not well understood. For example, Baf60c (Smarcd3) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart development is not fully understood. We found that constitutive loss of Baf60c leads to embryonic cardiac hypoplasia and pronounced cardiac dysfunction. Conditional deletion of Baf60c in cardiomyocytes resulted in postnatal dilated cardiomyopathy with impaired contractile function. Baf60c regulates a gene expression program that includes genes encod

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48

Holmlund, Mattias. "The role of the BLADE-ON-PETIOLE genes in the regulation of plant growth and development /." Umeå : Dept. of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200869.pdf.

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49

Töhönen, Virpi. "Novel genes in gonadal development /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-115-2/.

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50

Braunreiter, Kara M. "Regulation of Oscillatory Gene Expression by Alternative Polyadenylation." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595517827933039.

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