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Dissertations / Theses on the topic 'Gene-targeted therapy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Harris, Jonathan David. "Targeted gene therapy for cancer." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309239.

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2

Samani, Amir Abbas. "IGF-IR targeted cancer gene therapy." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18206.

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Since the declaration of “War on cancer” in 1971, and with the insight provided by recent advances in human genetics and in molecular technology , the field of cancer biology has been expanded rapidly providing hope that a cure for this lethal disease will be found. One of the major contributions of the field of cell biology to the understanding of malignant diseases has been the identification of growth factors and their receptors as major promoters of transformation and malignant progression. In particular, the appreciation of the central role that receptor tyrosine kinases (RTK) play in d

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3

Mckiver, Bryan D. "SND1-Targeted Gene Therapy for Hepatocellular Carcinoma." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5676.

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Staphylococcal nuclease and tudor-domain containing 1 (SND1) is an oncogene for a wide variety of cancers, including hepatocellular carcinoma (HCC). SND1 is a multifunctional protein regulating gene expression of proto-oncogenes and tumor suppressor genes, making SND1 a prime target for developing cancer therapeutics. This notion is especially attributed to HCC as most patients are diagnosed in advanced stages and the therapeutic options available for these patients are severely limited. In this study, we evaluated the therapeutic potential of a replication-defective adenovirus vector deliveri

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4

Sabine, Victoria Saranne. "Targeted gene therapy for canine osteosarcoma : preliminary investigations." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1642/.

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Osteosarcoma (OS) is the most common bone cancer in dogs. It is biologically aggressive and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene therapy strategies. Canine OS is considered to be a good model for human OS. The aims of this study were to:  examine the site incidence of canine OS retrieved from Glasgow University Veterinary School (GUVS) histology database;  perform TP53 mutational analysis in canine OS cases diagnosed at GUVS;  i

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5

Shaw, James Alistair MacGregor. "Towards muscle-targeted gene therapy for diabetes mellitus." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325232.

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6

Diaz, Marcano Rosa Maria. "Viral vectors for targeted gene therapy of cancer." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267735.

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7

Monfort, Dagmara Anne. "Recombinant Elastin Based Nanoparticles for Targeted Gene Therapy." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6627.

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Gene therapy is a technique used to inactivate, replace or insert a corrective copy of a defective gene in order to help diseased tissues to function properly. Gene therapy is a promising treatment for many diseases cancer, cystic fibrosis, and Parkinson’s. There are different methods to introduce a gene to the cell; one of them is the use of viruses. Among viruses, lentiviruses have been popular vectors for gene delivery due to their efficient mode of gene delivery. However, the non-specific delivery of genes associated with viruses may result in undesirable side effects. Here, we propose a h

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8

Taylor, Sarah Louise. "Development of an ultrasound-targeted retroviral gene therapy vector." Thesis, Institute of Cancer Research (University Of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436328.

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9

Denby, Laura. "Development of targeted gene therapy vectors for cardiovascular disease." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422499.

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10

Jackson, Laura. "Oxygen-regulated gene expression in Escherichia coli and hypoxia-targeted gene therapy." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414676.

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11

Anderson, B. Kevin Rice Kevin G. "Glycan targeted gene delivery to the dendritic cell SIGN receptor." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/328.

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12

Wattanakaroon, Wanida. "Development of an interleukin 2 receptor targeted gene therapy vehicle." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3724.

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The effectiveness of most chemotherapeutic regimens is limited by the toxicity of the therapy to normal healthy cells. Therapies to selectively modulate abnormal T cells bearing the interleukin 2 receptor (IL-2R) have been developed to treat diseases associated with aberrant immune response. This study describes the development and optimization of a targeted gene or oligonucleotide therapy vehicle to IL-2R bearing T cells for selective elimination of these cells. In this work, a monoclonal antibody to the IL-2R was used to target the oligonucleotide delivery vehicle which consisted of a polyam

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13

Patterson, Gillian. "Incretin-based muscle-targeted gene therapy for type 2 diabetes." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3367.

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According to WHO (August 2011), 346 million people worldwide have diabetes and, of those, 90% have type 2 diabetes (T2DM). This equates to approximately $465 billion (USD) in healthcare costs. Current treatments, which include various different drug types, both oral and injectable, are somewhat effective (i.e. do not prevent associated complications) but also still heavily rely on patient and/or care-giver regimen adherence for the therapies to be effective. One of the most recent classes of drugs is known as Glucagon-like peptide 1 receptor (GLP-1-R) agonists. Current treatment interval exten

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14

Niessen, Stijn Johannes Maria. "Towards muscle-targeted-gene-therapy for human and canine diabetes mellitus." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559063.

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15

Boast, Kate. "Analysis and exploitation of hypoxia response elements for targeted gene therapy." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341901.

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16

Mohmoud, Aiman. "Towards plasmid-mediated muscle-targeted incretin-based gene therapy for diabetes." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531740.

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17

Zarovni, Natasa. "Targeted delivery of TNF-Î± to tumor vessels : gene therapy approach." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403840.

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18

Kia, Kojouri Azadeh. "A novel double-targeted bacteriophage vector for systemic cancer gene therapy." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11085.

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A successful cancer gene therapy requires systemic gene delivery vectors capable of efficient and selective gene transfer to tumour sites. Two main approaches have been undertaken for targeted cancer gene therapy: i) restriction of transgene expression in tumour cells by using tumour specific promoters and ii) selective delivery of vectors of gene therapy to tumours by ligand targeting. Amongst many characterised tumour specific promoters, the stress-inducible promoter of the Glucose-regulated protein 78 (Grp78) gene holds great potential to improve the practice of cancer gene therapy as its a

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19

Nicklin, Stuart Anthony. "Targeted adenovirus-mediated gene transfer to human vascular endothelium." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310591.

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20

Maguire, Katie K. "Targeted gene repair of frameshift mutations insights into the mechanism and applications for gene therapy /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 174 p, 2007. http://proquest.umi.com/pqdweb?did=1362519101&sid=40&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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21

Lee, Kin-wah Terence, and 李建華. "Targeted gene delivery using a receptor-mediated gene transfer system and chemosensitivity in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3122295X.

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The Best MPhil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize<br>published_or_final_version<br>Pathology<br>Master<br>Master of Philosophy

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22

Al-Derwish, Omer. "Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir : combined gene targeted radiotherapy and suicide gene therapy for prostate cancer." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/220/.

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The strategy of suicide gene therapy in cancer is based on the idea of enabling tumour cells, by gene transfer, to convert a non-toxic pro-drug into a toxic product. Previous work has shown that the combination of herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) transfer with the pro-drug ganciclovir (GCV) to be a promising suicide gene therapy in cancer. Unlike several other gene therapy systems, early-phase clinical trials of this strategy have shown encouraging results. Therefore, methods to improve its therapeutic efficacy are urgently sought. The thymidine analogue 5-iodo-2’-fl

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23

Grünwald, Geoffrey. "Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-158988.

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24

Tsafa, Effrosyni. "Broad strategies into engineering superior targeted gene therapy vectors derived from bacteriophage viruses." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/61571.

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Chemotherapy is the most commonly used treatment for cancer. While chemotherapeutic drugs such as doxorubicin provide cure in some cases, chemotherapy is toxic and has serious side-effects. Another disadvantage is that some types of cancer develop resistance to chemotherapy. Lowering the doses of these drugs will make them safer but would decrease their efficacy. A solution to this would be to combine low doses of these anticancer drugs with a safe anticancer approach. Cancer gene therapy is an alternative and promising approach of cancer treatment. In our group we are using the adeno-associat

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25

Eleftheriadou, Ioanna. "Development of novel targeted lentiviral vectors for gene therapy of motor neuron diseases." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/27243.

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Motor Neuron Diseases (MND) including Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA) are neurodegenerative diseases that can cause progressive paralysis and premature death, while there are no treatments available up to date. Gene therapy using lentiviruses has been successful at alleviating symptoms and extending survival in murine models of both. Restricting transduction to specific cells, is critical for safe and efficient gene therapy. The aim of this study was to generate novel lentiviral vectors with tropism to motor neurons (MNs) using surface engineering, that in

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26

梁頌偉 and Chung-wai Leung. "Novel gene transfer vector targeted high affinity IL-2 receptor bearing cell." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31226280.

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27

Leung, Chung-wai. "Novel gene transfer vector targeted high affinity IL-2 receptor bearing cell /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25248698.

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28

Shirley, Rachel. "Development of targeted gene delivery vectors to assess cardiac overexpression of ACE2 in vivo." Connect to e-thesis, 2008. http://theses.gla.ac.uk/171/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Faculty of Medicine, Division of Cardiovascular and Medical Science, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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29

Fullerton, Natasha Eileen. "Gene therapy and targeted radiotherapy applied to bladder and prostate cancer : examination of radiation-induced bystander effects in targeted radiotherapy." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438687.

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30

Ratanamart, Jarupa. "Immunogenicity, efficiency and transcriptional regulation of plasmin-mediated muscle-targeted insulin gene therapy for diabetes." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431132.

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31

Teschner, Kathrin [Verfasser]. "Optimization of rAAV mediated targeted suicide gene therapy, rAAV manufacturing and downstream processing / Kathrin Teschner." Bielefeld : Universitätsbibliothek Bielefeld, 2020. http://d-nb.info/1209672375/34.

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32

Erebor, Joan Onyebuchi. "Synthesis and evaluation of targeted dendrisomes as novel gene and drug delivery systems for cancer therapy." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30187.

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33

Shi, Qiwen. "GADD45a-Targeted Suicide Gene Therapy for the Prevention or Treatment of Non-Small Cell Lung Carcinoma." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1436485198.

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34

Zeng, Yan. "T-cell mediated suppression of neuroblastoma following fractalkine gene therapy is amplified by targeted IL-2." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15401.

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Das Induzieren und Aufrechterhalten einer tumor-protektiven Immunität sind wesentliche Ziele in der Immuntherapie des Neuroblastoms. Eine Erhöhung der Anzahl von tumor-infiltrierenden Leukozyten könnte ein Weg sein, um dieses Ziel zu erreichen. Fractalkine ist ein besonderes TH1 CX3C Chemokin, welches sowohl Adhäsion und Migration von Leukozyten vermittelt. Gerichtetes IL-2 (ch14.18-IL-2) wurde durch eine genetische Fusion von anti-GD2 Antikörper mit IL-2 hergestellt, damit IL-2 spezifisch in das Mikromilieu von Neuroblastomen gebracht werden kann. In dieser Arbeit habe ich die Hypothese gete

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35

Wilson, Magdalene Obiageli. "Constitutive and regulated (pro)insulin secretion in optimised in vitro models of muscle targeted diabetes gene therapy." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427317.

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36

Ray, Sunetra. "A novel bi-directional transcriptional amplification system to monitor transcriptionally targeted gene therapy by tissue specific promoters." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1580823011&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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37

Quinn, Gary. "Cloning and characterisation of the promoter for the prostate specific membrane antigen gene : a candidate for targeted gene therapy for prostate cancer." Thesis, University of York, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288044.

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38

Grünwald, Geoffrey [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy / Geoffrey Grünwald. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1038151805/34.

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39

Pigini, Paolo <1991&gt. "Neuroblastoma targeted therapy: employment of CRISPR gene-editing to explore relevant markers and potential targets in aggressive tumours." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8752/1/Pigini_Paolo_tesi.pdf.

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Neuroblastoma is a tumour originating from the sympathetic nervous system, and represents the most common extracranial solid cancer in childhood. Despite the malignancy is extremely heterogeneous, about 25% of all cases is characterized by MYCN-gene amplification, aggressive tumour and poor survival. The network of genes that are deregulated in this group of patients represents a focal point for targeted-therapy discovery. Along this research line, the first objective of the present project was to investigate the prognostic significance of a single nucleotide polymorphism (SNP) located in the

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40

Günes, Serap. "MODIFICATION OF VESICULAR STOMATITIS VIRUS G PROTEIN FOR TARGETED GENE DELIVERY INTO PSCA-POSITIVE TUMOR CELLS." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1182861723404-04537.

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Gene therapy is a promising treatment option for cancer. Ideally, a therapeutic gene is delivered specifically into tumor cells sparing the neighboring normal cells. For this purpose gene delivery vectors are designed that can recognize structures, which are exclusively expressed on tumor cells (i.e. the tumor-associated antigens -TAA-). Retroviral vectors are commonly used for gene therapy by modifying the envelope protein responsible for the recognition of the target cell. The Vesicular Stomatitis Virus G protein (VSV-G) is a well-liked choice for pseudotyping the retroviral vectors since it

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41

Yang, Luhan. "Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11117.

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The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined as targeted changes to the genome, posits to deliver the promise of genomic revolution to transform basic science and personalized medicine. This thesis aims to contribute to this scientific endeavor with a particular focus on the development of effective human genome engineering tools.

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42

Klutz, Kathrin. "Molecularly targeted imaging and radionuclide therapy of non-thyroidal tumors following viral and non-viral sodium iodide symporter (NIS) gene delivery." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-136957.

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43

Nakaoku, Takashi. "Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma." Kyoto University, 2016. http://hdl.handle.net/2433/215443.

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リポジトリの登録にあたっては、Peer reviewされた最終版のみ可能であり、その際には下記の出版社のウェブサイトのアドレスを記載することが求められる。当該論文は2014年6月の出版であり、12ヶ月を経過していることから、公開には差し支えはない。http://clincancerres.aacrjournals.org/content/20/12/3087.full<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19617号<br>医博第4124号<br>新制||医||1015(附属図書館)<br>32653<br>京都大学大学院医学研究科医学専攻<br>(主査)教授小川誠司, 教授野田亮, 教授伊達洋至<br>学位規則第4条第1項該当

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44

Sun, Wenchao. "DNA Nanoparticles for Non-viral Gene Therapy: Mechanistic Studies and Targeting." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1327614453.

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45

Vasser, Geneva M. "Manipulation of the moloney murine leukemia virus envelope protein in an effort to develop directly and indirectly targeted retroviral vectors for use in human gene therapy." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-031-Vasser-Index.html.

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Thesis (M.S. )--University of Tennessee Health Science Center, 2008<br>Title from title page screen (viewed on Sept. 17, 2008). Research advisor: Lorraine M. Albritton, Ph.D. Document formatted into pages (x, 138 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 40-48).

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46

Zeng, Yan [Verfasser], H. [Gutachter] Lode, R. [Gutachter] Erttmann, and R. [Gutachter] Xiang. "T-cell mediated suppression of neuroblastoma following fractalkine gene therapy is amplified by targeted IL-2 / Yan Zeng ; Gutachter: H. Lode, R. Erttmann, R. Xiang." Berlin : Humboldt-Universität zu Berlin, 2006. http://d-nb.info/1208077031/34.

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47

Klutz, Kathrin [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Molecularly targeted imaging and radionuclide therapy of non-thyroidal tumors following viral and non-viral sodium iodide symporter (NIS) gene delivery / Kathrin Klutz. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2010. http://d-nb.info/1017688311/34.

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48

Oliveira, Mónica Catarina Castro. "Proteasome-proteins: are these putative targets for basal-like breast cancer therapy with AAV-vectors?" Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/18553.

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Mestrado em Biologia Molecular e Celular<br>O cancro da mama do tipo basal (BLBC) é um grupo de tumores muito agressivo associado a um mau prognóstico. De momento, não existe nenhum tratamento eficaz para o BLBC, uma vez que rapidamente adquirem resistência às terapias normalmente usadas. Assim, é urgente encontrar novas abordagens para tratar esta doença. Com base em dados anteriores, o objetivo geral deste estudo foi avaliar se o PSMA2, uma proteína do proteassoma, seria um alvo putativo para a inibição para terapia em BLBC. Desta forma, o primeiro objetivo específico foi avaliar o efeito

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49

Lacombe, Laurie. "CRISPR-Cas9-based strategies for enhanced targeted integration." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL047.

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La transplantation de cellules souches et progénitrices hématopoïétiques (CSPH) corrigées autologues est une stratégie prometteuse pour traiter les troubles génétiques sanguins, immunitaires et métaboliques en raison de leur capacité d'autorenouvellement et de différenciation en cellules sanguines variées. Une des méthodes les plus utilisées pour modifier les CSPH repose sur les outils d'édition de gènes comme les nucléases CRISPR/Cas9. L'intégration ciblée via CRISPR-Cas9 permet l'insertion précise de séquences thérapeutiques, offrant une source durable de cellules corrigées La cassure double

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50

Stachler, Matthew D. "Design and engineering of capsid modified AAV-Based vectors targeted towards angiogenic and proliferating vasculature." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1180370373.

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