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Journal articles on the topic 'General biochemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 April 2024

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1

Fartushok, Tetiana V., Nadiia V. Fartushok, Yu M. Fedevych, and Vladyslav V. Pyndus. "HISTORY OF BIOCHEMISTRY IN LVIV." Wiadomości Lekarskie 75, no. 4 (2022): 881–90. http://dx.doi.org/10.36740/wlek202204124.

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The aim: The purpose of this literature review is to shed light on the development of biochemical knowledge in the Lviv region and on prominent figures in the development of biochemistry during the Second World War. Materials and methods: Review of literature published before 2020. We searched the literature using the search terms ‘biochemists’, ‘ Lviv National Medical University’, ‘second World War’. Conclusions: The development of biological research in Lviv can be divided into two historical stages: 1) from the beginning of the founding of Lviv University in 1661 to the First World War; 2) between the First and Second World Wars and after the Second World War. Biochemical research was initiated at the Medical Faculty of Lviv University. In 1939, the Lviv State Medical Institute was established on the basis of the Medical Faculty of the University, where a powerful department of biochemistry functioned, which was headed by a worldclass biochemist – Jakub Parnas.

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2

Wood, E. J. "General biochemistry (second edition)." Biochemical Education 17, no. 2 (April 1989): 110. http://dx.doi.org/10.1016/0307-4412(89)90041-1.

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3

Baron, D. N. "Ideas towards a General Theory of Clinical Biochemistry." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 23, no. 6 (November 1986): 615–23. http://dx.doi.org/10.1177/000456328602300601.

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Clinical biochemistry, as an independent discipline within medical science, has developed its own body of theory and practice, and as such it cannot only be concerned with collecting observations. A simple report (plasma potassium=5·3 mmol/L*) is used as a model to discuss the problems of understanding measured chemical changes in the body in disease, and how these lead towards a general theory. These include the nature of the analysand and the reference base; accuracy and identification of the analyte; how disturbances of the steady state contribute to changes in a static result; the implications of precision; differences between activity, concentration and content; the convention of arithmetical concentration; and the meaning of ‘abnormal’, and of derived terms such as ‘predictive value’ and ‘decision level’. Clinical biochemists/chemical pathologists, with their understanding of all these and related problems, must act as the necessary bridge between analysts and clinicians.

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4

Cohen, Norman R. "Biochemistry and the general public." Biochemical Education 14, no. 2 (April 1986): 60–63. http://dx.doi.org/10.1016/0307-4412(86)90062-2.

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5

Fernández, Rolando Hernández, and Agustín Vicedo Tomey. "Use of general principles in teaching biochemistry." Biochemical Education 19, no. 4 (October 1991): 182–84. http://dx.doi.org/10.1016/0307-4412(91)90091-l.

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6

Danchin, A. "General principles of biochemistry of the elements." Biochimie 70, no. 3 (March 1988): 457–58. http://dx.doi.org/10.1016/0300-9084(88)90224-6.

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7

Bruce Martin, R. "General principles of biochemistry of the elements." Trends in Biochemical Sciences 13, no. 11 (November 1988): 455–56. http://dx.doi.org/10.1016/0968-0004(88)90223-x.

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8

Wolfson, Adele J., Susan L. Rowland, Gwendolyn A. Lawrie, and Anthony H. Wright. "Student conceptions about energy transformations: progression from general chemistry to biochemistry." Chem. Educ. Res. Pract. 15, no. 2 (2014): 168–83. http://dx.doi.org/10.1039/c3rp00132f.

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Students commencing studies in biochemistry must transfer and build on concepts they learned in chemistry and biology classes. It is well established, however, that students have difficulties in transferring critical concepts from general chemistry courses; one key concept is “energy.” Most previous work on students' conception of energy has focused on their understanding of energy in the context of physics (including the idea of “work”) and/or their understanding of energy in classical physical and inorganic chemistry contexts (particularly Gibbs Free Energy changes, the second law of thermodynamics, and equilibrium under standard conditions within a closed system). For biochemistry, students must go beyond those basic thermodynamics concepts of work, standard energy changes, and closed systems, and instead they must consider what energy flow, use, and transformation mean in living, open, and dynamic systems. In this study we explored students' concepts about free energy and flow in biological chemical reactions and metabolic pathways by surveys and in-depth interviews. We worked with students in general chemistry classes and biochemistry courses in both an Australian and a US tertiary institution. We address three primary questions (i) What are the most common alternative conceptions held by students when they explain energy-related phenomena in biochemistry?, (ii) What information do students transfer from introductory chemistry and biology when they are asked to consider energy in a biological reaction or reaction pathway?, and (iii) How do students at varying levels of competence articulate their understandings of energy in pathways and biological reactions? The answers to these questions are used to build a preliminary learning progression for understanding “energy” in biochemistry. We also propose crucial elements of content knowledge that instructors could apply to help students better grasp this threshold concept in biochemistry.

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9

Ngai, Courtney, and Hannah Sevian. "Probing the Relevance of Chemical Identity Thinking in Biochemical Contexts." CBE—Life Sciences Education 17, no. 4 (December 2018): ar58. http://dx.doi.org/10.1187/cbe.17-12-0271.

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The solving of problems in biochemistry often uses concepts from multiple disciplines such as chemistry and biology. Chemical identity (CI) is a foundational concept in the field of chemistry, and the knowledge, thinking, and practices associated with CI are used to answer the following questions: “What is this substance?” and “How is it different from other substances?” In this study, we examined the relevance of CI in biochemical contexts and first explored the ways in which practicing biochemists consider CI relevant in their work. These responses informed the development of creative exercises (CEs) given to second-semester biochemistry students. Analysis of the student responses to these CEs revealed that students incorporated precursors to CI thinking in more than half of their responses, which were categorized by seven previously identified themes of CI relevant to the presented biochemical contexts. The prevalence of these precursors in student responses to the CEs, coupled with the examples provided by practicing biochemists of contexts in which CI is relevant, indicate that CI thinking is relevant for both students training to be biochemists and practicing biochemists.

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10

Hunter, Tony. "My biochemical journey from a Cambridge undergraduate to the discovery of phosphotyrosine." Biochemist 43, no. 6 (December 23, 2021): 74–77. http://dx.doi.org/10.1042/bio_2021_197.

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The most notable moment in my career as a biochemist was the discovery of phosphotyrosine, a somewhat serendipitous finding that turned out to have some very important consequences, notably, in human cancer. My career as a biochemist which has spanned nearly 60 years, began when I was 16. At the time, I was in the sixth form at Felsted School, a boarding school in Essex England, and my biology master, David Sturdy, elected to teach me some extracurricular biochemistry, giving me one-on-one tutorials on glycolysis and the TCA cycle. These early biochemistry lessons turned out to be invaluable because I was able to regurgitate them to answer a question in the University of Cambridge scholarship exam in the autumn of 1960. As a result, I was lucky enough to be awarded an Exhibition at Gonville and Caius College, the college where my father had studied for a medical degree during World War II. When I arrived in Cambridge in October 1962 to read natural sciences (see Figure 1), it was a natural choice to take biochemistry as one of my three required first-year courses. The Part I biochemistry course was taught by a series of excellent lecturers, including Philip Randle (a prominent diabetes researcher who described the Randle Cycle), Brian Chappell (who discovered mitochondrial transporters) and Asher Korner (a pioneer of cell free systems to study protein synthesis). It quickly became clear that biochemistry was an exciting subject, and Brian Chappell, my biochemistry supervisor at Caius, made supervisions a lot of fun. I also took Part I courses in invertebrate zoology and, importantly, organic chemistry, which gave me insights into how the metabolites we were learning about in biochemistry worked as chemicals.

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11

Kolter, Thomas. "Ganglioside Biochemistry." ISRN Biochemistry 2012 (December 19, 2012): 1–36. http://dx.doi.org/10.5402/2012/506160.

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Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are summarized.

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12

Brammar, W. J. "Patricia Hannah Clarke. 29 July 1919 — 28 January 2010." Biographical Memoirs of Fellows of the Royal Society 61 (January 2015): 39–51. http://dx.doi.org/10.1098/rsbm.2015.0012.

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Patricia Hannah Clarke was a distinguished British biochemist and microbiologist who won an international reputation for her work on microbial evolution. After completing the Natural Sciences Tripos at the University of Cambridge at the beginning of World War II, she chose to work for the Armaments Research Department, before moving into microbiological research on bacterial toxoids. She was appointed to an assistant lectureship in biochemistry at University College London in 1953, eventually becoming Professor of Microbial Biochemistry in 1974. Her pioneering work on the directed evolution of bacterial metabolic capability led to her election to Fellowship of the Royal Society in 1976. Patricia gave dedicated service to the scientific community through her many years of committee work with the Royal Society, the Biochemical Society and the Society for General Microbiology. She was a passionate advocate of the importance of equal opportunities for women in education and scientific careers.

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13

Rimac, Vladimira, Anja Jokic, Sonja Podolar, Jelena Vlasic Tanaskovic, Lorena Honovic, and Jasna Lenicek Krleza. "General position of Croatian medical biochemistry laboratories on autovalidation." Biochemia medica 30, no. 2 (June 14, 2020): 242–49. http://dx.doi.org/10.11613/bm.2020.020702.

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Introduction: Autovalidation (AV) is an algorithm based on predefined rules designed, among others, to automate and standardize the postanalytical phase of laboratory work. The aim of this study was to examine the overall opinion of Croatian medical biochemistry laboratories regarding various aspects of AV. Material and methods: This retrospective study is an analysis of the responses of a survey about AV comprised of 18 questions, as part of Module 10 (“Postanalytical phase of laboratory testing”) of national External Quality Assessment program, administered by the Croatian Centre for Quality Assessment in Laboratory Medicine. Results were reported as percentages of total number of participants in survey or as proportions of observed data if the overall number of data was <100. Results: 121 laboratories responded to the survey, of which 76% do not use AV, while 11% of laboratories use AV in routine laboratory work. 16/29 laboratories implemented semi-automated AV for general biochemistry (7/29), haematology (5/29), and coagulation (4/29) tests. Analytical measurement ranges, critical values, flags from analysers, interference indices and delta check were the most commonly used rules in the algorithm. 12/29 laboratories performed validation of AV with less than 500 samples (8/29). 7/13 laboratories report the percentage of AV being 20-50%, while 10/13 answered that introduction of AV significantly reduced turnaround time (TAT) (for 20 - 25%), especially for biochemistry tests. Conclusions: Despite of its numerous benefits (i.e. shorter TAT, less manual validation, standardization of the postanalytical phase), only a small number of Croatian laboratories use AV.

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14

Burkett, Allan R. "General, organic, and biochemistry (Brown, William H.; Rogers, Elizabeth)." Journal of Chemical Education 65, no. 6 (June 1988): A169. http://dx.doi.org/10.1021/ed065pa169.2.

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15

SINGH, PADUMAN. "BIOCHEMISTRY." Medical Journal Armed Forces India 56, no. 4 (October 2000): 366. http://dx.doi.org/10.1016/s0377-1237(17)30245-9.

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16

Sabater, Mikel, and Neil Forbes. "Avian haematology and biochemistry 2. Biochemistry." In Practice 37, no. 3 (March 2015): 139–42. http://dx.doi.org/10.1136/inp.g6976.

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17

Diven, Warren F. "Biochemistry." Annals of Otology, Rhinology & Laryngology 97, no. 4_suppl (July 1988): 23–27. http://dx.doi.org/10.1177/00034894880970s407.

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18

Lecocq, A. L. "Biochemistry." Biochimie 73, no. 5 (May 1991): 628. http://dx.doi.org/10.1016/0300-9084(91)90039-4.

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19

Blundell, Tom. "Introduction." Biochemist 33, no. 5 (October 1, 2011): 4–5. http://dx.doi.org/10.1042/bio03305004.

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This issue of The Biochemist is focused on biochemistry in China. It is timely because it reflects the history of biochemical research collaboration between Chinese and UK scientists, not only by looking back over the last century, but also by reviewing some of the strengths of biochemical research in China in 2011.

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20

Yadin, David. "From the Oxford student editorial team." Biochemist 32, no. 5 (October 1, 2010): 34. http://dx.doi.org/10.1042/bio03205034.

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Last November, Professor Stuart Ferguson in the Oxford Department of Biochemistry approached me to tell me about the competition run by The Biochemist to find a student editorial team. He had seen our magazine, Phenotype, and thought we would stand a good chance. Without his initial encouragement, we would probably not have entered the competition.

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21

Edelman, Aleksander, and Margarida D. Amaral. "General introduction to section C: Biochemistry and Biophysics of CFTR." Journal of Cystic Fibrosis 3 (August 2004): 67. http://dx.doi.org/10.1016/j.jcf.2004.05.015.

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22

Bloom, Stephen. "Clinical biochemistry⇓." BMJ 328, no. 7445 (April 17, 2004): s153.2—s154. http://dx.doi.org/10.1136/bmj.328.7445.s153-a.

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23

Gorman, Jessica. "Unnatural Biochemistry." Science News 163, no. 4 (January 25, 2003): 53. http://dx.doi.org/10.2307/4014289.

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24

Horsman, Geoff P., and David L. Zechel. "Phosphonate Biochemistry." Chemical Reviews 117, no. 8 (October 27, 2016): 5704–83. http://dx.doi.org/10.1021/acs.chemrev.6b00536.

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25

Kerkut, G. A. "Harper's biochemistry." Comparative Biochemistry and Physiology Part A: Physiology 91, no. 2 (January 1988): 403. http://dx.doi.org/10.1016/0300-9629(88)90437-9.

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26

Kerkut, G. A. "Pheromone biochemistry." Comparative Biochemistry and Physiology Part A: Physiology 92, no. 1 (January 1989): 151. http://dx.doi.org/10.1016/0300-9629(89)90761-5.

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27

Taylor, Dr Alan, Professor Ian S. Young, Dr Padmanna Negali, Dr Richard Neary, and Dr Cathy Hay. "Biochemistry study day." Morecambe Bay Medical Journal 5, no. 2 (August 1, 2006): 58–59. http://dx.doi.org/10.48037/mbmj.v5i2.365.

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A Biochemistry study day was held on 1st March 2006 at Furness General Hospital (FGH), courtesy of the Education Centre and Astra Zeneca. Dr Alan Taylor, consultant chemical pathologist, reports on the meeting for the Journal. He describes the contribution of Professor Ian S Young, Professor of Medicine and Clinical Biochemistry at Queens University Belfast. His lecture on the origins of atheroma, which in a masterly way condensed many years of research into one hour, ranks alongside Dr Denis Burkitt’s lecture on the origins of bowel disease (the inaugural lecture in the new theatre at FGH in 1986) and Professor Nick Hales’s on the origins of diabetes (presented in 1998 at FGH). The topics selected for the study day were designed for primary care staff in particular, because they have overtaken secondary care as the main users of clinical biochemistry services.

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28

Ostrovsky, Michail A. "Biochemistry." Applied Biochemistry and Biotechnology 59, no. 1 (April 1996): 105–6. http://dx.doi.org/10.1007/bf02787862.

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29

Helser, Terry L. "Biochemistry Wordsearches." Journal of Chemical Education 85, no. 4 (April 2008): 515. http://dx.doi.org/10.1021/ed085p515.

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30

Jallon, J. M., and M. Cobb. "Pheromone Biochemistry." Biochimie 71, no. 5 (May 1989): 694–95. http://dx.doi.org/10.1016/0300-9084(89)90167-3.

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31

J.K, Phukan, Bora G.K, and Yadav S. "DUTIES AND RESPONSIBILITIES OF CLINICAL BIOCHEMIST IN PSYCHIATRY HOSPITAL." International Journal of Advanced Research 8, no. 9 (September 30, 2020): 837–40. http://dx.doi.org/10.21474/ijar01/11731.

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The duties and responsibilities of Clinical Biochemists are evolving. Some of theclassical duties and responsibilities of Clinical Biochemists in a Tertiary Psychiatry hospital are basically in the area of research, education and service. Some general rules of success for younger Clinical Biochemist in his/her fieldare also important topic of discussion. We are living in very competitive timesand Clinical Biochemists mustlearn to adapt very quickly to the continuing changes in our discipline. We are yet to realize the best times of this exciting profession.

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32

Gaudillière, J. M. "Foundations of modern biochemistry, Early adventures in biochemistry." Biochimie 78, no. 4 (January 1996): 292–93. http://dx.doi.org/10.1016/0300-9084(96)82202-4.

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33

Thomas, Melonie. "GCSEs to BSc -- where to begin?" Biochemist 28, no. 5 (October 1, 2006): 57–58. http://dx.doi.org/10.1042/bio02805057.

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Melonie Thomas, a newly qualified Biomedical Science graduate from Southampton University, was the youngest delegate presenting at BioScience2006. Throughout school and university, students face hefty decisions as they pick their options. Many will probably have some doubt about what to study, why they want to study it or where it will take them. Not everyone has a long-term plan, especially at the age of 17, and it's important to point out that (sometimes) this is okay. Melonie claims not to have enjoyed science at school. She didn't even know about Biochemistry when she selected her AS options of Maths, French, English Literature, Business Studies and General Studies, along with a Spanish GCSE. Not a promising choice of interviewee for The Biochemist you might think, but all will become clear… as it did to Melonie.

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34

Pollard, T. D. "Biochemistry; A Clinical Companion to Accompany Biochemistry, 5th ed." JAMA: The Journal of the American Medical Association 290, no. 12 (September 24, 2003): 1648. http://dx.doi.org/10.1001/jama.290.12.1648.

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35

Firth, C. "Clinical Biochemistry Automation A report from a UK District General Hospital." Journal of the Association for Laboratory Automation 6, no. 4 (September 1, 2001): 84–86. http://dx.doi.org/10.1016/s1535-5535(04)00148-0.

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36

Frowen, Colin, and Gary Firth. "Clinical Biochemistry Automation a Report from a UK District General Hospital." JALA: Journal of the Association for Laboratory Automation 6, no. 4 (August 2001): 84–86. http://dx.doi.org/10.1016/s1535-5535-04-00148-0.

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37

Honek, John F. "Glyoxalase biochemistry." Biomolecular Concepts 6, no. 5-6 (December 1, 2015): 401–14. http://dx.doi.org/10.1515/bmc-2015-0025.

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AbstractThe glyoxalase enzyme system utilizes intracellular thiols such as glutathione to convert α-ketoaldehydes, such as methylglyoxal, into D-hydroxyacids. This overview discusses several main aspects of the glyoxalase system and its likely function in the cell. The control of methylglyoxal levels in the cell is an important biochemical imperative and high levels have been associated with major medical symptoms that relate to this metabolite’s capability to covalently modify proteins, lipids and nucleic acid.

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38

Randall, David. "The next 25 years: vertebrate physiology and biochemistry." Canadian Journal of Zoology 65, no. 4 (April 1, 1987): 794–96. http://dx.doi.org/10.1139/z87-126.

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Predicting the future accurately is at best difficult: general trends are often self-evident, specific predictions are often wrong. In the next 25 years in vertebrate physiology and biochemistry I anticipate an increase in the importance of multidisciplinary group approaches, with such groups working on problems of a broad integrative nature. I think that physiology and biochemistry will play a larger role in contributing answers to many of the controversial issues in general biology, for example, enlarging the functional base for evolutionary theory. I think that the administration of science in general is becoming more rigid and research directives more centralized, resulting in less freedom of action for individual scientists in Canada. Vertebrate physiology and biochemistry, however, continue to be very active and will continue to be so over the next 25 years.

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39

Doran, Heather. "Enterprising biochemistry." Biochemist 44, no. 1 (January 20, 2022): 1. http://dx.doi.org/10.1042/bio_2021_206.

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40

Sansom, Clare. "Biochemistry bytes." Biochemist 26, no. 6 (December 1, 2004): 47–48. http://dx.doi.org/10.1042/bio02606047.

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41

Sansom, Clare. "Tweeting biochemistry." Biochemist 32, no. 1 (February 1, 2010): 31. http://dx.doi.org/10.1042/bio03201031.

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I will start this first Cyberbiochemist of 2010 with something of a confession. I am still a Twitter newbie. My Twitter account is (at the time of writing) less than 3 months old, and I am still working out how it best fits into my particular media mix. So, why do I write about the interface between Twitter and biochemistry? Maybe my main motivation is to learn more.

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42

Willmott, Chris. "Biochemistry Forever." Biochemist 40, no. 4 (August 1, 2018): 3. http://dx.doi.org/10.1042/bio04004003.

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43

Whitby, L. "Clinical Biochemistry." Journal of Clinical Pathology 38, no. 5 (May 1, 1985): 600. http://dx.doi.org/10.1136/jcp.38.5.600-a.

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44

Eckersall, P., and T. Douglas. "New biochemistry tests." Veterinary Record 122, no. 10 (March 5, 1988): 240. http://dx.doi.org/10.1136/vr.122.10.240.

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45

Glynn, L. E. "Silicon biochemistry." Cell Biochemistry and Function 5, no. 1 (January 1987): 77–78. http://dx.doi.org/10.1002/cbf.290050112.

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46

Butterworth, P. J. "PDQ biochemistry." Cell Biochemistry and Function 5, no. 4 (October 1987): 312. http://dx.doi.org/10.1002/cbf.290050417.

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47

Cote, G. G., and R. C. Crain. "Biochemistry of Phosphoinositides." Annual Review of Plant Physiology and Plant Molecular Biology 44, no. 1 (June 1993): 333–56. http://dx.doi.org/10.1146/annurev.pp.44.060193.002001.

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48

Ismail, A. A., and J. H. Barth. "Wrong biochemistry results." BMJ 323, no. 7315 (September 29, 2001): 705–6. http://dx.doi.org/10.1136/bmj.323.7315.705.

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49

Watson, I. D. "Wrong biochemistry results." BMJ 324, no. 7334 (February 16, 2002): 422a—422. http://dx.doi.org/10.1136/bmj.324.7334.422/a.

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50

Borst, Piet. "Edward Charles Slater. 16 January 1917 — 26 March 2016." Biographical Memoirs of Fellows of the Royal Society 63 (January 2017): 527–51. http://dx.doi.org/10.1098/rsbm.2016.0024.

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With the death of Edward Charles Slater, Bill for insiders, biochemistry loses one of the key players in the field of bioenergetics in the second half of the twentieth century. Raised in Australia and trained as a chemist, he joined the lab of David Keilin FRS in Cambridge for his PhD where he discovered a new component of the mitochondrial respiratory chain, an Fe-S protein, long known as the Slater factor. After a brief post-doc period in the lab of Severo Ochoa in New York, where Slater started studies on oxidative phosphorylation that would remain his major interest, he returned to Keilin's institute. In 1953 he formulated there his chemical hypothesis for the mechanism of oxidative phosphorylation that would dominate the field until displaced by the chemi-osmotic theory of Peter Mitchell FRS. In 1955 Slater moved to Amsterdam, The Netherlands, where he built up one of the largest and most successful biochemistry labs in Europe. He was not only an excellent biochemist, but also an outstanding mentor and a gifted administrator who turned Biochimica et Biophysica Acta ( BBA ) into the largest and one of the most influential biochemical journals of the 1960s and 1970s and who contributed to the governance of numerous organizations, such as the International Union of Biochemistry and Molecular Biology (IUBMB).

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