Journal articles: 'General Pharmacology'

1

Gheorghiu, Monica. "General Homeopathic Pharmacology." Acta Endocrinologica (Bucharest) 3, no. 3 (2007): 385. http://dx.doi.org/10.4183/aeb.2007.385.

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Hite, Mark. "Safety Pharmacology Approaches." International Journal of Toxicology 16, no. 1 (January 1997): 23–31. http://dx.doi.org/10.1080/109158197227332.

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This article presents views of a discipline termed safety pharmacology or general pharmacology. This is an area that provides information through empirical studies on new pharmacologic agents at doses above those thought to be efficacious and the no-toxicologic-effect level (NOEL) above which unwanted effects might occur. The usefulness of batteries of tests is discussed, and comments are made about the value of these in the drug developmental process.

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Mortin, Lawrence I., Christopher J. Horvath, and Michael S. Wyand. "Safety Pharmacology Screening: Practical Problems in Drug Development." International Journal of Toxicology 16, no. 1 (January 1997): 41–65. http://dx.doi.org/10.1080/109158197227350.

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Undesired pharmacologic activities of novel drugs or biologies may limit development of a therapeutic prior to the characterization of any toxicologic effects. In rodent species, general pharmacology assays have traditionally been used to screen new agents for pharmacologic effects on the central and peripheral nervous systems, the autonomic nervous system and smooth muscles, the respiratory and cardiovascular systems, the digestive system, and the physiologic mechanisms of water and electrolyte balance. In large animal species, such as dogs and nonhuman primates, smaller numbers of animals per study limit their use for screening assays, but these species may play an important role in more detailed mechanistic studies. For drugs and biologies that must be tested in nonhuman primates because of species-specific action of the test agent, functional pharmacologic data are often collected during acute or subacute toxicity studies. This requires careful experimental design to minimize any impact pharmacologic effects or instrumentation may have on the assessment of toxicity. In addition, with many new therapies targeted at immunologic diseases, the pharmacologic effect of therapeutics on the immune system presents new challenges for pharmacologic profiling. The application of pharmacology assays by organ system in both rodent and large animal species are discussed, as well as practical issues in assessing pharmacology endpoints in the context of toxicity studies.

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Kinter, Lewis B. "General pharmacology/safety pharmacology: Customers, biologics, and glps." Drug Development Research 35, no. 3 (July 1995): 142–44. http://dx.doi.org/10.1002/ddr.430350305.

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Terézhalmy, Géza T., and V. Brian Gagliardi. "GENERAL PRINCIPLES OF PHARMACOLOGY." Dental Clinics of North America 38, no. 4 (October 1994): 585–601. http://dx.doi.org/10.1016/s0011-8532(22)00178-1.

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6

Coward, D. M. "General Pharmacology of Clozapine." British Journal of Psychiatry 160, S17 (May 1992): 5–11. http://dx.doi.org/10.1192/s0007125000296840.

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Clozapine shows neuroleptic-like inhibition of locomotor activity and conditioned avoidance responding in rodents, although tolerance develops on repeated treatment. EEG-based studies show strong arousal-inhibiting activity of clozapine as well as neuroleptic-like effects on both caudate spindle duration and rat sleep-waking patterns. Effects such as apomorphine blockade, catalepsy and strong increases of plasma prolactin levels are not seen, however, and chronic treatment does not lead to dopamine D2 receptor supersensitivity. Binding studies show clozapine's highest affinities to be for dopamine D4, 5-HT1c, 5-HT2, α1, muscarinic and histamine H1 receptors, but moderate affinity is also seen for many other receptor subtypes. Microdialysis studies indicate a preferential interaction with striatal D1 receptors, whereas autoradiographical studies indicate upregulation of D1 and downregulation of 5-HT2 receptors after chronic clozapine. Clarification of the mechanisms underlying clozapine's special attributes is often hampered by a failure to examine compounds which show a close chemical relationship to clozapine, but which produce extrapyramidal side-effects in man, such as clothiapine, loxapine and amoxapine.

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Mizuguchi, Kiyoshi, Kozo Kanai, and Toshiji Igarashi. "Update of general pharmacology/safety pharmacology studies in Japan." Drug Development Research 38, no. 2 (June 1996): 114–15. http://dx.doi.org/10.1002/(sici)1098-2299(199606)38:2<114::aid-ddr5>3.0.co;2-m.

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8

Lemoine, P. "General practitioners and clinical pharmacology." Psychiatry and Psychobiology 4, no. 4 (1989): 241–44. http://dx.doi.org/10.1017/s0767399x00002820.

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SummaryIt is difficult to undertake field studies with non marketed psychotropic drugs because of two apparently contradictory conditions : on the one hand, the methodology has to be rigorously controlled, and on the other hand, such studies have to be carried out in their future environment by general practitioners (GPs). Bearing in mind the lack of training and experience regarding this kind of approach, the author adopted a discussion group method according to the techniques developed by M. Balint. The study group comprised five GPs, a clinical pharmacology expert and a doctor from the pharmaceutical laboratory which had developed the test drug. These persons met on a monthly basis over a one year period. In the present paper, the author indicates the benefits of such a methodology, based on six years’ experience and several trials, with special emphasis placed on the pedagogical aspects.

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9

Bowmer, C. J. "Principle lead principles in general pharmacology." Trends in Pharmacological Sciences 10, no. 6 (June 1989): 252. http://dx.doi.org/10.1016/0165-6147(89)90272-1.

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10

Sepúlveda, Pablo O., Valeria Epulef, and Gustavo Campos. "Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia." Journal of Clinical Medicine 10, no. 10 (May 18, 2021): 2175. http://dx.doi.org/10.3390/jcm10102175.

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Background: Pediatric sedation and anesthesia techniques have plenty of difficulties and challenges. Data on the pharmacologic, electroencephalographic, and neurologic response to anesthesia at different brain development times are only partially known. New data in neuroscience, pharmacology, and intraoperative neuromonitoring will impact changing concepts and clinical practice. In this article, we develop a conversation to guide the debate and search for a view more attuned to the updated knowledge in neurodevelopment, electroencephalography, and clinical pharmacology for the anesthesiologic practice in the pediatric population.

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11

Evans, Christopher, Alison Hoggarth, and Colm Lanigan. "Pharmacology of pain management in general practice." InnovAiT: Education and inspiration for general practice 9, no. 12 (October 13, 2016): 742–52. http://dx.doi.org/10.1177/1755738016665132.

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Pain is described as the fifth vital sign, yet its importance is frequently not fully recognised, despite 68 000 000 analgesic prescriptions being dispensed annually. GPs treat pain in the context of a wide spectrum of patient conditions and co-morbidities, recognising potential drug interactions and side-effects. They also factor in the patient’s anxieties, coping strategies, cultural background and previous experiences of pain. It is no wonder that we frequently do not get it right first time. This article discusses the pharmacological action of the major groups of analgesic drugs, considers common pitfalls, and suggests appropriate drug dosing. A titrated multi-modal approach is recommended to target nociceptor pain pathways, and to reduce the side-effects caused by large doses of monotherapy. It discusses the novel use of analgesic agents previously only used for chronic pain. It does not, however, discuss acute-on-chronic pain, drug tolerance, drug addiction or complex pain management.

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12

De, Vries TP. "Presenting clinical pharmacology and therapeutics: general introduction." British Journal of Clinical Pharmacology 35, no. 6 (June 1993): 577–79. http://dx.doi.org/10.1111/j.1365-2125.1993.tb04184.x.

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13

Shenfield, Gillian M. "Integrating clinical pharmacology teaching with general practice." British Journal of Clinical Pharmacology 45, no. 4 (April 1998): 399–401. http://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00690.x.

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14

Scholtz, Jean M. "General Principles and Pharmacology of Antineoplastic Agents." Journal of Pharmacy Practice 4, no. 1 (February 1991): 3–10. http://dx.doi.org/10.1177/089719009100400102.

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15

Anderson, Brian J., Karel Allegaert, and Nicholas H. G. Holford. "Population clinical pharmacology of children: general principles." European Journal of Pediatrics 165, no. 11 (June 29, 2006): 741–46. http://dx.doi.org/10.1007/s00431-006-0188-y.

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16

Adi Try Wurjatmiko. "The Effects of Music Therapy Intervention on the Pain and Anxiety Levels of Cancer Patient: A Systematic Review." International Journal of Nursing Education 11, no. 4 (November 21, 2019): 14–18. http://dx.doi.org/10.37506/ijone.v11i4.3936.

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Cancer constitutes one of illnesses which frequently causes pain and anxiety. The management of cancer pain comprises the pharmacology and non-pharmacology. The pharmacologic management, at some points, fails to provide a complete relief from the pain and instead gives rises to unwanted side-effects on the patients that necessitate the employment of non-pharmacologic management such as music therapy. The purpose of this systematic review is to discover the effects of music therapy on the pain and anxiety levels on the cancer patient. Systematic Review encompasses literature obtained from library research and internet research using search engine such as PubMed, Medline, Proquest, dan Elsevier. The articles comprise the full text journals published between the years of 2009-2016. 87.50% out of 8 articles (1 systematic review) demonstrates that music therapy effectively alleviates the pain to 75.00% and lowers the anxiety level, and 12.50% of insignificant palliative effect in terms of the pain and anxiety. Music therapy is an effective non-pharmacologic therapy to alleviate or relieve the cancer patients of the resultant pain and anxiety.

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17

Paiman, Arif, Ahmad Mohammadi, Rafia Inam, Aqsa Ameen, and Mubashar Rehman. "Oral Drug Delivery to the Experimental Animals, A Mini Review." Global Drug Design & Development Review I, no. I (December 30, 2016): 19–26. http://dx.doi.org/10.31703/gdddr.2016(i-i).03.

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In several pharmacologic, pharmacology, and alternative medicine studies, oral administration of medication or test substances to experimental animals is needed. It is clinically sound and recommended to administer test substances to experimental animals along the same route that they are taken or expected to be taken by humans as general bioavailability; the pharmacology and pharmacology parameters obtained for the drug will depend significantly on the route chosen to administer it. The lack of ready access to high-quality oral tubing built for different species, as well as a widespread lack of technical expertise to properly use out-of-the-box techniques in this part of the world, has made this route controversial among medicine scientists. The typical problems and difficulties associated with the oral administration of test product solutions were avoided by mistreating either the syringe alone or incorporating it into the animals feeds or drinkables. This jury-rigged oral tubing was also used to ensure that the expected doses were correctly administered in each case.

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18

Anand Dhonde, Shreya, and Rahul Sudam Jadhav. "New Developments in Behavioural Pharmacology." International Journal of Science and Research (IJSR) 12, no. 10 (October 5, 2023): 117–21. http://dx.doi.org/10.21275/mr23928202832.

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19

CLARK, B. "General pharmacology, pharmacokinetics, and toxicology of nedocromil sodium." Journal of Allergy and Clinical Immunology 92, no. 1 (July 1993): 200–202. http://dx.doi.org/10.1016/0091-6749(93)90108-r.

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20

Lees, P., S. A. May, and Q. A. McKellar. "Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat: 1 General pharmacology." Journal of Small Animal Practice 32, no. 4 (April 1991): 183–93. http://dx.doi.org/10.1111/j.1748-5827.1991.tb00541.x.

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21

Burnham, Nora, and Donna L. Betcher. "Pharmacology." Journal of the Association of Pediatric Oncology Nurses 6, no. 1 (January 1989): 23–25. http://dx.doi.org/10.1177/104345428900600109.

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22

Betcher, Donna, and Nora Burnham. "Pharmacology." Journal of the Association of Pediatric Oncology Nurses 6, no. 2 (January 1989): 43–46. http://dx.doi.org/10.1177/104345428900600237.

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23

Prevost, Suzanne S. "Pharmacology." Nursing Clinics of North America 40, no. 1 (March 2005): xi—xii. http://dx.doi.org/10.1016/j.cnur.2004.11.001.

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24

Casavant, Marcel J. "Pharmacology." JAMA 295, no. 23 (June 21, 2006): 2791. http://dx.doi.org/10.1001/jama.295.23.2791.

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25

Maxson, Rebecca. "Pharmacology." Physician Assistant Clinics 8, no. 2 (April 2023): i. http://dx.doi.org/10.1016/s2405-7991(22)00131-1.

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26

Prichard, Brian N., and Barrie R. Graham. "I1 Imidazoline Agonists. General Clinical Pharmacology of Imidazoline Receptors." Drugs & Aging 17, no. 2 (August 2000): 133–59. http://dx.doi.org/10.2165/00002512-200017020-00005.

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27

Kissin, Igor, and Kamen V. Vlassakov. "Pharmacology of General Anesthetics: Quantitative History of Research Attractiveness." Anesthesia & Analgesia 132, no. 5 (March 1, 2021): 1486–88. http://dx.doi.org/10.1213/ane.0000000000005441.

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28

Ryu, Keun, Hae Rhee, Inho Jung, Taek-Soo Kim, Sung Lee, Guang-Jin Im, Namkyu Lee, et al. "General Pharmacology of the New Antiviral Agent SK 1899." Arzneimittelforschung 50, no. 04 (December 27, 2011): 395–403. http://dx.doi.org/10.1055/s-0031-1300220.

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29

Raiten, Daniel J. "Nutrition and pharmacology: general principles and implications for HIV." American Journal of Clinical Nutrition 94, no. 6 (November 9, 2011): 1697S—1702S. http://dx.doi.org/10.3945/ajcn.111.019109.

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30

Bunting, Patricia B., and Peter K. S. Siegl. "Models used to assess cardiovascular function in general pharmacology." Drug Development Research 32, no. 4 (August 1994): 256–59. http://dx.doi.org/10.1002/ddr.430320410.

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31

Keijsers, Carolina J. P. W., Anne J. Leendertse, Adrianne Faber, Jacobus R. B. J. Brouwers, Dick J. de Wildt, and Paul A. F. Jansen. "Pharmacists' and general practitioners' pharmacology knowledge and pharmacotherapy skills." Journal of Clinical Pharmacology 55, no. 8 (April 30, 2015): 936–43. http://dx.doi.org/10.1002/jcph.500.

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32

Archangelshy., P. I. "Materials for pharmacology hydrastinine." Journal of obstetrics and women's diseases 6, no. 5 (September 24, 2020): 518–20. http://dx.doi.org/10.17816/jowd65518-520.

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The author made experiments both on frogs and warm-blooded animals; the first examined the General effect of hydrastinine, and then its effect on the nervous system, blood and lymph circulation; to warm-blooded-well, after reading General effect, we studied the influence on the circulatory system and the uterus.

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33

Pawson, Adam, Joanna Sharman, Helen Benson, Elena Faccenda, Michael Spedding, and Anthony Harmar. "The Guide to PHARMACOLOGY portal: A one-stop pharmacology shop." Biochemist 35, no. 1 (February 1, 2013): 36–39. http://dx.doi.org/10.1042/bio03501036.

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Most medicines are chemical substances that work by interacting with specific target proteins in the body. The International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) have joined forces to develop the Guide to PHARMACOLOGY (www.guidetopharmacology.org), a portal to information on the targets of licensed drugs and other targets of current research interest, such as those linked to human disease. Over the next 3 years, with support from the Wellcome Trust, IUPHAR and BPS, the Guide to PHARMACOLOGY portal will be expanded to cover all the targets of current licensed drugs and those with potential to be targets of future therapeutics. Our goal is to provide scientists, doctors, allied professions and the general public with a ‘one-stop shop’ source of information on how drugs work, and to help researchers to design experiments using the appropriate reagents.

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34

Jeevendra Martyn, J. A., David J. Greenblatt, and Darrell R. Abernathy. "Pharmacology." Journal of Burn Care & Rehabilitation 8, no. 1 (January 1987): 77. http://dx.doi.org/10.1097/00004630-198701000-00017.

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35

Roberts, J. "Pharmacology." Gerontologist 28, no. 3 (June 1, 1988): 428–29. http://dx.doi.org/10.1093/geront/28.3.428.

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36

Higbee, Martin D. "The Geriatric Patient: General Physiologic and Pharmacologic Considerations." Journal of Pharmacy Practice 13, no. 4 (August 2000): 250–62. http://dx.doi.org/10.1177/089719000001300403.

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The elderly patient is not simply an older adult and needs to have drug therapy applied with caution with regard to the physiologic changes associated with aging that impact the pharmacology and pharmacokinetics of medicinals used in this population. The elderly patient has a number of physiologic changes with age that affect metabolism, distribution, and excretion. In addition, there exists information that demonstrates changes in the pharmacodynamics of drug therapy commonly used in the elderly. This article reviews these changes.

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37

Kim, Eun, Rae Lee, Seung Lee, and Dong Kim. "General Pharmacology of IY-81149, a New Proton Pump Inhibitor." Arzneimittelforschung 51, no. 01 (December 27, 2011): 51–59. http://dx.doi.org/10.1055/s-0031-1300002.

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38

Lee, Jang-hern, Hyun-woo Kim, Young-bae Kwon, Myung-soo Kang, Dong-won Choi, Jun-ho Na, Oh-kyung Kwon, et al. "General Pharmacology Studies on ß-Domain Deleted Recombinant Factor VIII." Arzneimittelforschung 50, no. 01 (December 28, 2011): 86–92. http://dx.doi.org/10.1055/s-0031-1300170.

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39

Kaiser, Robert A., Roy Erwin, Stephen D. Tichenor, Douglas E. Regalia, and Dennis J. Meyer. "Integration of cardiovascular safety pharmacology endpoints into general toxicology studies." Journal of Pharmacological and Toxicological Methods 62, no. 2 (September 2010): e30. http://dx.doi.org/10.1016/j.vascn.2010.11.103.

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40

Horn, Wilhelm. "General pharmacology, toxicology and future clinical development of HOE 077." Journal of Hepatology 13 (January 1991): S63—S65. http://dx.doi.org/10.1016/0168-8278(91)90009-z.

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41

Kozuch, Patricia L., and Stephen B. Hanauer. "General Principles and Pharmacology of Biologics in Inflammatory Bowel Disease." Gastroenterology Clinics of North America 35, no. 4 (December 2006): 757–73. http://dx.doi.org/10.1016/j.gtc.2006.09.005.

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42

Bockaert, J., L. Fagni, H. Ouadid, J. Nargeot, and A. Dumuis. "5-HT4 receptors: general pharmacology and control of ionic channels." European Neuropsychopharmacology 2, no. 3 (September 1992): 230–32. http://dx.doi.org/10.1016/0924-977x(92)90080-r.

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43

Greenberg, Stanley S., Jeff Paul, and Alan Luisi. "General pharmacology of CK-2130: A new selective positive inotrope." Drug Development Research 21, no. 4 (1990): 301–24. http://dx.doi.org/10.1002/ddr.430210405.

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44

Lumley, Cynthia E. "General pharmacology, the international regulatory environment, and harmonization of guidelines." Drug Development Research 32, no. 4 (August 1994): 223–32. http://dx.doi.org/10.1002/ddr.430320406.

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45

Nerkar, Amit G. "Pharmacology actual teaching aesthetics." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 3 (August 15, 2023): 79–82. http://dx.doi.org/10.18231/j.ctppc.2023.018.

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Pharmacology is one of the most interesting common subjects of studies to pharmaceutical sciences or pharmacy, medicine and some life sciences and biomedical sciences undergraduates, postgraduates, doctorates, and Post doctorates. The art of teaching Pharmacology and Clinical Pharmacology lies in the in-depth knowledge of the tutor or the in-charge professor. This editorial deals with actual teaching aesthetics of teaching Pharmacology and Clinical Pharmacology right away from the basics and in advance science. The article will be useful for all the tutors and professors in pharmaceutical sciences or pharmacy, medicine, and biomedical sciences to implement effective teaching and learning in pharmacology and clinical pharmacology.

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46

Peiré García, Mª Asunción. "Pediatric pharmacology." ANALES RANM 136, no. 02 (September 25, 2019): 218–21. http://dx.doi.org/10.32440/ar.2019.136.02.rev17.

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47

Shenfield, Gillian M., David G. Le Couteur, and Laurent P. Rivory. "Clinical pharmacology." Medical Journal of Australia 176, no. 1 (January 2002): 9. http://dx.doi.org/10.5694/j.1326-5377.2002.tb04242.x.

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48

Wright, Rollin M., and Rick W. Warpula. "Geriatric Pharmacology." Journal of the American Podiatric Medical Association 94, no. 2 (March 1, 2004): 90–97. http://dx.doi.org/10.7547/87507315-94-2-90.

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Adverse drug effects are common in elderly patients but can often be avoided. Judicious prescribing practices require the clinician to be aware of age-related changes in drug absorption, distribution, metabolism, and elimination. Clinicians may need to adjust drug dose, frequency, or the choice of drug altogether as they consider the physiologic changes of aging. This article reviews prescribing situations with elderly patients commonly encountered by the podiatric physician. Strategies for medication management are provided to minimize the risk of adverse drug events in the older patient. (J Am Podiatr Med Assoc 94(2): 90-97, 2004)

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49

Potter, Julia M. "Basic pharmacology." Medical Journal of Australia 159, no. 9 (November 1993): 576. http://dx.doi.org/10.5694/j.1326-5377.1993.tb138042.x.

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50

Chowdhury, Mahbub M. U., and Alex V. Anstey. "Dermatological Pharmacology." Medicine 28, no. 11 (2000): 12–16. http://dx.doi.org/10.1383/medc.28.11.12.27500.

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Journal articles on the topic 'General Pharmacology'

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