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Journal articles on the topic 'Genes and physical activity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Booth, F. W., and M. J. Laye. "The future: genes, physical activity and health." Acta Physiologica 199, no. 4 (2010): 549–56. http://dx.doi.org/10.1111/j.1748-1716.2010.02117.x.

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2

MOON, MARY ANN. "Physical Activity Offset Effect of ‘Obesity Genes’." Family Practice News 38, no. 19 (2008): 30. http://dx.doi.org/10.1016/s0300-7073(08)71240-4.

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3

Lightfoot, J. Timothy. "Finding Physical Activity Genes Using Inbred Strains." Medicine & Science in Sports & Exercise 38, Supplement (2006): 68. http://dx.doi.org/10.1249/00005768-200605001-00674.

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4

Cerit, Mesut. "RELATIONSHIP BETWEEN GENES, PHYSICAL ACTIVITY & METABOLIC DISEASES." RESEARCH IN PHYSICAL EDUCATION, SPORT AND HEALTH 9, no. 2 (2020): 57–64. http://dx.doi.org/10.46733/pesh20920057c.

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Wilkinson, A. V., K. P. Gabriel, J. Wang, et al. "Sensation-seeking genes and physical activity in youth." Genes, Brain and Behavior 12, no. 2 (2012): 181–88. http://dx.doi.org/10.1111/gbb.12006.

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CHOMISTEK, ANDREA K., DANIEL I. CHASMAN, NANCY R. COOK, ERIC B. RIMM, and I.-MIN LEE. "Physical Activity, Genes for Physical Fitness, and Risk of Coronary Heart Disease." Medicine & Science in Sports & Exercise 45, no. 4 (2013): 691–97. http://dx.doi.org/10.1249/mss.0b013e3182784e9f.

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7

Kujala, Urho M. "Physical activity, genes, and lifetime predisposition to chronic disease." European Review of Aging and Physical Activity 8, no. 1 (2011): 31–36. http://dx.doi.org/10.1007/s11556-010-0077-2.

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Kasim-Karakas, Sidika E. "Nutrition and Fitness: Diet, Genes, Physical Activity and Health." American Journal of Clinical Nutrition 76, no. 3 (2002): 696. http://dx.doi.org/10.1093/ajcn/76.3.696.

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9

Bray, Molly S. "Interactions between genes and physical activity in cardiovascular disease." Current Cardiovascular Risk Reports 2, no. 4 (2008): 318–24. http://dx.doi.org/10.1007/s12170-008-0058-4.

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Santiago, Jose A., James P. Quinn, and Judith A. Potashkin. "Physical Activity Rewires the Human Brain against Neurodegeneration." International Journal of Molecular Sciences 23, no. 11 (2022): 6223. http://dx.doi.org/10.3390/ijms23116223.

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Physical activity may offset cognitive decline and dementia, but the molecular mechanisms by which it promotes neuroprotection remain elusive. In the absence of disease-modifying therapies, understanding the molecular effects of physical activity in the brain may be useful for identifying novel targets for disease management. Here we employed several bioinformatic methods to dissect the molecular underpinnings of physical activity in brain health. Network analysis identified ‘switch genes’ associated with drastic hippocampal transcriptional changes in aged cognitively intact individuals. Switc

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Chisholm, D. J., K. Samaras, T. Markovic, D. Carey, N. Lapsys, and L. V. Campbell. "Obesity: genes, glands or gluttony?" Reproduction, Fertility and Development 10, no. 1 (1998): 49. http://dx.doi.org/10.1071/r98016.

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Distribution as well as amount of fat has health implications; central abdominal fat seems to be the major contributor to insulin resistance and risk of diabetes, hypertension and cardiovascular disease. Physical activity and diet affect overall adiposity; moreover, exercise specifically reduces visceral fat. The sexes differ in fat distribution; in particular, pre-menopausal women, despite greater overall adiposity, have much less visceral fat than men. There is a strong genetic determination of overall obesity and central abdominal adiposity. Genes regulating obesity (e.g. Ob) could modulate

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Suyematsu, Megan E., Jessica Whiteley, and Katrina Bond. "Genes versus behavior: Relationships among health attitudes and physical activity." Medicine & Science in Sports & Exercise 40, Supplement (2008): S359. http://dx.doi.org/10.1249/01.mss.0000323437.20338.65.

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13

Światowy, Witold Józef, Hanna Drzewiecka, Michalina Kliber, et al. "Physical Activity and DNA Methylation in Humans." International Journal of Molecular Sciences 22, no. 23 (2021): 12989. http://dx.doi.org/10.3390/ijms222312989.

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Physical activity is a strong stimulus influencing the overall physiology of the human body. Exercises lead to biochemical changes in various tissues and exert an impact on gene expression. Exercise-induced changes in gene expression may be mediated by epigenetic modifications, which rearrange the chromatin structure and therefore modulate its accessibility for transcription factors. One of such epigenetic mark is DNA methylation that involves an attachment of a methyl group to the fifth carbon of cytosine residue present in CG dinucleotides (CpG). DNA methylation is catalyzed by a family of D

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14

Booth, Frank W., and Simon J. Lees. "Fundamental questions about genes, inactivity, and chronic diseases." Physiological Genomics 28, no. 2 (2007): 146–57. http://dx.doi.org/10.1152/physiolgenomics.00174.2006.

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Currently our society is faced with the challenge of understanding the biological basis for the epidemics of obesity and many chronic diseases, including Type 2 diabetes. Physical inactivity increases the relative risk of coronary artery disease by 45%, stroke by 60%, hypertension by 30%, and osteoporosis by 59%. Moreover, physical inactivity is cited as an actual cause of chronic disease by the US Centers of Disease Control. Physical activity was obligatory for survival for the Homo genus for hundreds of thousands of years. This review will present evidence that suggests that metabolic pathwa

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Di Liegro, Schiera, Proia, and Di Liegro. "Physical Activity and Brain Health." Genes 10, no. 9 (2019): 720. http://dx.doi.org/10.3390/genes10090720.

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Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear. It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes. Many studies have shown that PA can reverse at least some of the unwanted effects of sedentary lifestyle, and can also contribute in delaying b

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16

Ziegler, Earle F. "Historical Perspective on “Quality of Life”: Genes, Memes, and Physical Activity." Quest 48, no. 3 (1996): 253–65. http://dx.doi.org/10.1080/00336297.1996.10484195.

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McCullough, Lauren E., Regina M. Santella, Rebecca J. Cleveland, et al. "Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk." Cancer Causes & Control 23, no. 12 (2012): 1949–58. http://dx.doi.org/10.1007/s10552-012-0072-1.

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AALTONEN, SARI, JAAKKO KAPRIO, URHO M. KUJALA, LEA PULKKINEN, RICHARD J. ROSE, and KARRI SILVENTOINEN. "The Interplay between Genes and Psychosocial Home Environment on Physical Activity." Medicine & Science in Sports & Exercise 50, no. 4 (2018): 691–99. http://dx.doi.org/10.1249/mss.0000000000001506.

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19

Leckie, Regina L., Andrea M. Weinstein, Jennifer C. Hodzic, and Kirk I. Erickson. "Potential Moderators of Physical Activity on Brain Health." Journal of Aging Research 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/948981.

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Age-related cognitive decline is linked to numerous molecular, structural, and functional changes in the brain. However, physical activity is a promising method of reducing unfavorable age-related changes. Physical activity exerts its effects on the brain through many molecular pathways, some of which are regulated by genetic variants in humans. In this paper, we highlight genes including apolipoprotein E (APOE), brain derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) along with dietary omega-3 fatty acid, docosahexaenoic acid (DHA), as potential moderators of the eff

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20

Lipman, Terri, and Linda Beth Tiedje. "Habitual Physical Activity in Children: The Role of Genes and the Environment." MCN, The American Journal of Maternal/Child Nursing 31, no. 3 (2006): 205. http://dx.doi.org/10.1097/00005721-200605000-00018.

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21

Stavrakakis, N., A. J. Oldehinkel, E. Nederhof, et al. "Plasticity genes do not modify associations between physical activity and depressive symptoms." Health Psychology 32, no. 7 (2013): 785–92. http://dx.doi.org/10.1037/a0030111.

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22

Franks, Paul W., Eric Ravussin, Robert L. Hanson, et al. "Habitual physical activity in children: the role of genes and the environment." American Journal of Clinical Nutrition 82, no. 4 (2005): 901–8. http://dx.doi.org/10.1093/ajcn/82.4.901.

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Insua, A., and J. Méndez. "Physical Mapping and Activity of Ribosomal RNA Genes in Mussel Mytilus Galloprovincialis." Hereditas 128, no. 3 (2004): 189–94. http://dx.doi.org/10.1111/j.1601-5223.1998.00189.x.

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McCullough, Lauren E., Regina M. Santella, Rebecca J. Cleveland, et al. "Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk." International Journal of Cancer 134, no. 3 (2013): 654–63. http://dx.doi.org/10.1002/ijc.28383.

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25

Chakravarthy, Manu V., and Frank W. Booth. "Eating, exercise, and “thrifty” genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases." Journal of Applied Physiology 96, no. 1 (2004): 3–10. http://dx.doi.org/10.1152/japplphysiol.00757.2003.

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Survival of Homo sapiens during evolution was dependent on the procurement of food, which in turn was dependent on physical activity. However, food supply was never consistent. Thus it is contended that the ancient hunter-gatherer had cycles of feast and famine, punctuated with obligate periods of physical activity and rest. Hence, gene selection in the Late-Paleolithic era was probably influenced by physical activity and rest. To ensure survival during periods of famine, certain genes evolved to regulate efficient intake and utilization of fuel stores. Such genes were termed “thrifty genes” i

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26

Magbanua, Mark Jesus Mendoza, Erin L. Richman, Eduardo V. Sosa, et al. "Physical activity and prostate gene expression in men with low-risk prostate cancer." Journal of Clinical Oncology 30, no. 5_suppl (2012): 189. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.189.

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189 Background: Physical activity (PA), in particular longer duration or higher intensity, may reduce the risk of PCa progression and PCa-specific mortality in men diagnosed with clinically localized PCa. However, the molecular mechanism(s) by which PA exerts its protective effect in the prostate remains unknown. We examined the correlation of PA and gene expression patterns in men with low risk prostate cancer who elected to undergo active surveillance. Methods: Morphologically normal prostate tissue was obtained from men who subsequently participated in a clinical trial focused on nutritiona

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27

Chambers, Jenni, Clare M. P. Roscoe, Corinna Chidley, Agnieszka Wisniewska, and Aparna Duggirala. "Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 22, no. 4 (2025): 637. https://doi.org/10.3390/ijerph22040637.

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Physical activity (PA) and body composition are important lifestyle factors that influence public health. Research suggests that DNA regions (CpG site locations) are differentially methylated in a physically active population. This meta-analysis aimed to identify CpG sites associated with various levels of PA and associated metabolic pathways. The meta-analysis followed PRISMA guidelines using PubMed, SportDISCUS, Embase, Scopus, Cochrane and Web of Science. Epigenomic analyses performed on DNA of participants with no underlying health conditions were included. Articles were screened using Ray

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Bey, Lionel, Nagabhavani Akunuri, Po Zhao, Eric P. Hoffman, Deborah G. Hamilton, and Marc T. Hamilton. "Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity." Physiological Genomics 13, no. 2 (2003): 157–67. http://dx.doi.org/10.1152/physiolgenomics.00001.2002.

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Physical inactivity and unloading lead to diverse skeletal muscle alterations. Our goal was to identify the genes in skeletal muscle whose expression is most sensitive to periods of unloading/reduced physical activity and that may be involved in triggering initial responses before phenotypic changes are evident. The ability of short periods of physical activity/loading as an effective countermeasure against changes in gene expression mediated by inactivity was also tested. Affymetrix microarrays were used to compare mRNA levels in the soleus muscle under three experimental treatments ( n = 20–

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29

Bouchard, Claude. "The Human Genome, Physical Activity, Fitness, and Health." Kinesiology Review 11, no. 1 (2022): 36–42. http://dx.doi.org/10.1123/kr.2021-0057.

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A summary of the evidence for a contribution of genetic variability to physical activity–related traits is presented. The availability of a reference human DNA sequence has made it possible to screen individuals and populations for the presence of genomic differences. Even though more than 100 million DNA variants have been identified, human beings share a genomic sequence, which is more than 99% identical. Four major lessons can be derived from ongoing genomic and genetic studies. First, the connection between a genotype and a phenotype is highly complex. Second, the expression of genes is re

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30

Gordon, Scott E. "Fitting into Our Genes: Evolutionary Theory of the Health Benefits of Physical Activity." Quest 71, no. 4 (2019): 375–86. http://dx.doi.org/10.1080/00336297.2019.1656652.

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31

Aaltonen, Sari, Jaakko Kaprio, Urho M. Kujala, Lea Pulkkinen, Richard J. Rose, and Karri Silventoinen. "The Interplay between Genes and Psychosocial Home Environment on Leisure-time Physical Activity." Medicine & Science in Sports & Exercise 50, no. 5S (2018): 348–49. http://dx.doi.org/10.1249/01.mss.0000536228.27516.f6.

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32

Lenard, Natalie R., and Hans-Rudolf Berthoud. "Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes." Obesity 16, S3 (2008): S11—S22. http://dx.doi.org/10.1038/oby.2008.511.

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33

Qiu, Jiaying, Jiajia Gu, Shiyi Chang, et al. "Exercise Reverses Immune-Related Genes in the Hippocampus of Multiple Sclerosis Patients." Neurology India 72, no. 1 (2024): 102–9. http://dx.doi.org/10.4103/ni.ni_27_22.

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Background: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelinating lesions in the white matter of the central nervous system. Studies have shown that exercise is beneficial for multiple sclerosis (MS). However, the molecular basis is largely unknown. Materials and Methods: We integrated multiple blood and hippocampus transcriptome data from subjects with physical activity or MS. Transcription change associations between physical activity and MS were analyzed with bioinformatic methods including GSEA (Gene Set Enrichment Analysis) and GO (Gene Ontology) ana

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ŚWITAŁA, KATARZYNA, and Agata Leońska-Duniec. "Physical activity and gene association with human obesity." Baltic Journal of Health and Physical Activity 13, no. 4 (2021): 99–111. http://dx.doi.org/10.29359/bjhpa.13.4.10.

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The obesity is a leading cause of health problems all over the world. It is a comlex health abnormality that is influenced by developmental, behavioural, environmental, and genetic factors. Although the role of physical activity and diet in regulation of body weight is well described, the genetic variants potentially influencing the characteristics and range of the body’s adaptive response to physical activity in healthy individuals still remains mostly unknown. The main aim of this study is to review current evidence, through a literature review and the results of our studies, on the influenc

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Estévez-López, Fernando, Diego F. Salazar-Tortosa, Daniel Camiletti-Moirón, et al. "Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study." Journal of Clinical Medicine 10, no. 9 (2021): 1902. http://dx.doi.org/10.3390/jcm10091902.

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Fatigue is a cardinal symptom in fibromyalgia. Fatigue is assumed to be the result of genetic susceptibility and environmental factors. We aimed at examining the role of genetic susceptibility for fatigue in southern Spanish women with fibromyalgia, by looking at single nucleotide polymorphisms in 34 fibromyalgia candidate-genes, at the interactions between genes, and at the gene-physical activity interactions. We extracted DNA from saliva of 276 fibromyalgia women to analyze gene-polymorphisms. Accelerometers registered physical activity and sedentary behavior. Fatigue was assessed with the M

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Komir, I. "GENETIC POLYMORPHISMS AND PHYSICAL ACTIVITY TO OPTIMIZE WEIGHT MAINTENANCE EFFORTS AND PREVENT CARDIOVASCULAR RISK FACTORS." East European Scientific Journal 2, no. 12(76) (2022): 22–28. http://dx.doi.org/10.31618/essa.2782-1994.2021.2.76.204.

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The development of cardiovascular diseases is due to the interaction of genes with environmental factors. The individual body's response to diet therapy and lifestyle modification also largely depends on genetic factors, in particular the presence of polymorphic variants of the ADRB2 (Gln27Glu), ADRB2 (Agr16Gly), ADRB3 (Trp64Agr), PPARG2 (Pro12Ala) and FABP genes. Despite recommendations for lifestyle modifications, it is especially important for patients with cardiovascular disease to achieve weight loss and maintenance. However, there are no studies comparing the effects of drug therapy and

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Caspers, Maarten, Sara Blocquiaux, Ruben Charlier, et al. "Intensity-Specific Differential Leukocyte DNA Methylation in Physical (In)Activity: An Exploratory Approach." Twin Research and Human Genetics 21, no. 2 (2018): 101–11. http://dx.doi.org/10.1017/thg.2018.10.

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The aim of this exploratory study was to investigate how sedentary behavior (SB) and physical activity (PA) influence DNA methylation at a global, gene-specific, and health-related pathway level. SB, light PA (LPA), and moderate-to-vigorous PA (MVPA) were assessed objectively for 41 Flemish men using the SenseWear Pro 3 Armband. CpG site-specific methylation in leukocytes was determined using the Illumina HumanMethylation 450 BeadChip. Correlations were calculated between time spent on the three PA intensity levels and global DNA methylation, using a z-score-based method to determine global DN

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38

Leamy, Larry J., Daniel Pomp, and J. Timothy Lightfoot. "Epistatic interactions of genes influence within-individual variation of physical activity traits in mice." Genetica 139, no. 6 (2011): 813–21. http://dx.doi.org/10.1007/s10709-011-9586-9.

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39

Rosso, Andrea L., Andrea L. Metti, Robert M. Boudreau, Nancy W. Glynn, W. Jack Rejeski, and Caterina Rosano. "DOPAMINE-RELATED GENES AND SUSTAINED PHYSICAL ACTIVITY ADHERENCE IN ADULTS AT RISK FOR DEMENTIA." Alzheimer's & Dementia 13, no. 7 (2017): P927. http://dx.doi.org/10.1016/j.jalz.2017.07.364.

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40

Dalle Carbonare, L., M. Mottes, S. Cheri, et al. "Increased Gene Expression of RUNX2 and SOX9 in Mesenchymal Circulating Progenitors Is Associated with Autophagy during Physical Activity." Oxidative Medicine and Cellular Longevity 2019 (October 15, 2019): 1–14. http://dx.doi.org/10.1155/2019/8426259.

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Lack of physical exercise is considered an important risk factor for chronic diseases. On the contrary, physical exercise reduces the morbidity rates of obesity, diabetes, bone disease, and hypertension. In order to gain novel molecular and cellular clues, we analyzed the effects of physical exercise on differentiation of mesenchymal circulating progenitor cells (M-CPCs) obtained from runners. We also investigated autophagy and telomerase-related gene expression to evaluate the involvement of specific cellular functions in the differentiation process. We performed cellular and molecular analys

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Navas-Carretero, Santiago, Rodrigo San-Cristobal, Ismael Alvarez-Alvarez, et al. "Interactions of Carbohydrate Intake and Physical Activity with Regulatory Genes Affecting Glycaemia: A Food4Me Study Analysis." Lifestyle Genomics 14, no. 3 (2021): 63–72. http://dx.doi.org/10.1159/000515068.

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<b><i>Introduction:</i></b> Carbohydrate intake and physical activity are related to glucose homeostasis, both being influenced by individual genetic makeup. However, the interactions between these 2 factors, as affected by genetics, on glycaemia have been scarcely reported. <b><i>Objective:</i></b> We focused on analysing the interplay between carbohydrate intake and physical activity levels on blood glucose, taking into account a genetic risk score (GRS), based on SNPs related to glucose/energy metabolism. <b><i>Methods:</i>&l

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Labhane, Ms Aarti. "Exercise Mimetics: Harnessing the Therapeutic Effects of Physical Activity." International Journal for Research in Applied Science and Engineering Technology 12, no. 3 (2024): 1692–97. http://dx.doi.org/10.22214/ijraset.2024.59159.

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Abstract: Over the past decade, there has been an increase in both scientific and commercial interest in finding bioactive oral substances, also known as "exercise pills" or "exercise mimetics," that replicate or enhance the benefits of exercise. The benefits of an active lifestyle for both the body and brain are becoming more and more obvious. However not everyone can exercise because of illness, trauma, or age-related disease. Both artificial and natural substances stimulate genes involved in the metabolic remodelling of skeletal muscle, activate some of the major regulators, and simulate ex

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Valeeva, E. V., I. Kh Valeeva, I. I. Semina, et al. "Dopamine receptors genes activity under chronic stress in rats." Biomics 13, no. 1 (2021): 1–7. http://dx.doi.org/10.31301/2221-6197.bmcs.2021-1.

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Stress response is a multifactorial condition which is formed under extreme environmental exposure due to various neuroendocrine systems interactions. Dopaminergic system plays a key role in stress response through the dopamine which effect is realized after binding with special dopamine receptors types D1-D5. Expression of these receptors varies in different tissues, organs and specific brain structures but there is a special interest in their genes expression level in peripheral blood that can be served as additional marker to evaluate the chronic stress degree. Herein we determine the influ

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Bociek, Arkadiusz. "Irisin - evidence for benefits resulting from physical activity." European Journal of Biological Research 9, no. 3 (2019): 165–72. https://doi.org/10.5281/zenodo.3385065.

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Irisin is a myokine with wide metabolic action, which makes it very similar to a hormone. Its serum level depends on the expression of the genes FNDC5 and PGC-1α which, in turn, are induced, among others, by physical activity, especially aerobic exercises. According to many studies, aerobic training lasting for 45-60 minutes significantly increased the level of irisin in blood or muscles, and was considerably more effective than endurance training. Irisin shows protective properties against type 2 diabetes by decreasing insulin-resistance and against atherosclerosis by the improvement of

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Nowak, Robert, Alicja Trzeciak-Ryczek, Andrzej Ciechanowicz, Andrzej Brodkiewicz, Elżbieta Urasińska, and Dorota Kostrzewa-Nowak. "The Impact of Different Types of Physical Effort on the Expression of Selected Chemokine and Interleukin Receptor Genes in Peripheral Blood Cells." Cells 12, no. 8 (2023): 1119. http://dx.doi.org/10.3390/cells12081119.

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This study aimed to assess the post-effort transcriptional changes of selected genes encoding receptors for chemokines and interleukins in young, physically active men to better understand the immunomodulatory effect of physical activity. The participants, aged 16–21 years, performed physical exercise tasks of either a maximal multistage 20 m shuttle-run test (beep test) or a repeated speed ability test. The expression of selected genes encoding receptors for chemokines and interleukins in nucleated peripheral blood cells was determined using RT-qPCR. Aerobic endurance activity was a positive

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Zhang, Jing, and Weizhen Zhang. "Can irisin be a linker between physical activity and brain function?" Biomolecular Concepts 7, no. 4 (2016): 253–58. http://dx.doi.org/10.1515/bmc-2016-0012.

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AbstractIrisin was initially discovered as a novel hormone-like myokine released from skeletal muscle during exercise to improve obesity and glucose dysfunction by stimulating the browning of white adipose tissue. Emerging evidence have indicated that irisin also affects brain function. FNDC5 mRNA and FNDC5/irisin immunoreactivity are present in various regions of the brain. Central irisin is involved in the regulation of neural differentiation and proliferation, neurobehavior, energy expenditure and cardiac function. Elevation of peripheral irisin level stimulates hippocampal genes related to

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47

Sanders, Chelsea L., Gail B. Rattinger, M. Scott Deberard, et al. "Interaction Between Physical Activity and Genes Related to Neurotrophin Signaling in Late-Life Cognitive Performance: The Cache County Study." Journals of Gerontology: Series A 75, no. 9 (2019): 1633–42. http://dx.doi.org/10.1093/gerona/glz200.

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Abstract Research indicates that lifestyle and genetic factors influence the course of cognitive impairment in aging, but their interactions have not been well-examined. This study examined the relationship between physical activity and genotypes related to brain-derived neurotrophic factor (BDNF) in predicting cognitive performance in a sample of older adults with up to 12 years of follow-up. Physical activity levels (sedentary, light, and moderate/vigorous) were determined for the sample of 3,591 participants (57% female) without dementia. The genotypes examined included BDNF gene single nuc

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Pescatello, Parducci, Livingston, and Taylor. "A Systematically Assembled Signature of Genes to be Deep-Sequenced for Their Associations with the Blood Pressure Response to Exercise." Genes 10, no. 4 (2019): 295. http://dx.doi.org/10.3390/genes10040295.

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: Background: Exercise is one of the best nonpharmacologic therapies to treat hypertension. The blood pressure (BP) response to exercise is heritable. Yet, the genetic basis for the antihypertensive effects of exercise remains elusive. Methods: To assemble a prioritized gene signature, we performed a systematic review with a series of Boolean searches in PubMed (including Medline) from earliest coverage. The inclusion criteria were human genes in major BP regulatory pathways reported to be associated with: (1) the BP response to exercise; (2) hypertension in genome-wide association studies (GW

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Wang, Jun, AnKang Li, ZhiGao Wang, XinHua Feng, Eric N. Olson, and Robert J. Schwartz. "Myocardin Sumoylation Transactivates Cardiogenic Genes in Pluripotent 10T1/2 Fibroblasts." Molecular and Cellular Biology 27, no. 2 (2006): 622–32. http://dx.doi.org/10.1128/mcb.01160-06.

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ABSTRACT Myocardin, a serum response factor (SRF)-dependent cofactor, is a potent activator of smooth muscle gene activity but a poor activator of cardiogenic genes in pluripotent 10T1/2 fibroblasts. Posttranslational modification of GATA4, another myocardin cofactor, by sumoylation strongly activated cardiogenic gene activity. Here, we found that myocardin's activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation. PIAS1 was involved in governin

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Lehmann, R., and C. Nusslein-Volhard. "The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo." Development 112, no. 3 (1991): 679–91. http://dx.doi.org/10.1242/dev.112.3.679.

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A group of maternal genes, the posterior group, is required for the development of the abdominal region in the Drosophila embryo. We have used genetic as well as cytoplasmic transfer experiments to order seven of the posterior group genes (nanos, pumilio, oskar, valois, vasa, staufen and tudor) into a functional pathway. An activity present in the posterior pole plasm of wild-type embryos can restore normal abdominal development in posterior group mutants. This activity is synthesized during oogenesis and the gene nanos most likely encodes this activity. The other posterior group genes have di

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