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Dissertations / Theses on the topic 'Genes identification'

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1

Yu, Zhan. "Identification of putative retrotransposition in genes." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18435.

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Retrotransposition is an active process in mammalian gene evolution. It involves the reverse transcription of an mRNA transcript and the subsequent re-integration of the resulting cDNA into genomic DNA. This study was to derive a complete picture of the role of gene retrotransposition in the genome evolution of vertebrates, particularly in mammals. A robust procedure to annotate putative retrogenes (PRs) was applied to eight vertebrate genomes (human, chimp, dog, cow, rat, mouse, chicken and the puffer-fish T. nigriviridis). Mammalian genomes were estimated to contain 400-800 PRs (up to ~4% of
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2

Thorarinsdottir, Thorhildur. "Identification of Smad4 transcriptional target genes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79147.

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Inactivating mutations of the TGF-beta signaling pathway, including SMAD4, have been identified in a wide variety of human tumors and can lead to resistance to TGF-beta induced growth arrest. SMAD4 itself has been firmly established as a tumor suppressor while despite the massive information gathered on TGF-beta signaling the contribution of SMAD4 inactivation in tumor progression remains elusive. It is largely unknown which particular genes involved in tumor progression require SMAD4 for their transcriptional regulation. Smad4-/- murine fibroblasts were shown to display normal growth i
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McAuley, Erica Zoe Prince of Wales Medical Research Institute Faculty of Medicine UNSW. "Identification of bipolar disorder susceptibility genes." Publisher:University of New South Wales. Prince of Wales Medical Research Institute, 2009. http://handle.unsw.edu.au/1959.4/43690.

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Bipolar affective disorder is a severe mood disorder, which is characterised by episodes of mania and depression. The aetiology of bipolar disorder remains elusive, with little known about the underlying biological, anatomical, or biochemical effects. However, family, twin and adoption studies provide evidence for a strong genetic component to the disorder. Due to the high heritability, familial clustering, and common population prevalence of the illness, molecular genetic studies can be implemented to identify bipolar disorder susceptibility genes. This thesis investigated the candidate gene
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4

Morrow, Michelle Ann. "Identification of genes controlling lymphocyte development." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620377.

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5

Rymer, Karen. "Identification of Candidate Genes for Craniosynostosis." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3782.

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Craniosynostosis is a disorder characterized by the premature fusing of cranial sutures in an infant. Premature closure of these sutures can lead to detrimental consequences on the development of a child. The two broad categories of craniosynostosis are classified as syndromic and nonsyndromic. Nonsyndromic craniosynostosis involves only the fusion of one or more sutures, whereas syndromic craniosynostosis involves other abnormalities throughout the body of the affected individual. Two of the families analyzed in this study were of the syndromic nature, and known FGFR mutations were discovered
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6

Andersson, Malin. "A method for identification of putatively co-regulated genes." Thesis, University of Skövde, Department of Computer Science, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-705.

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<p>The genomes of several organisms have been sequenced and the need for methods to analyse the data is growing. In this project a method is described that tries to identify co-regulated genes. The method identifies transcription factor binding sites, documented in TRANSFAC, in the non-coding regions of genes. The algorithm counts the number of common binding sites and the number of unique binding sites for each pair of genes and decides if the genes are co-regulated. The result of the method is compared with the correlation between the gene expression patterns of the genes. The method is test
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7

Münzner, Ulrike. "Gene fishing in Cataglyphis fortis – Identification of genes inthe desert ant." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20455.

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<p>The desert ant Cataglyphis fortis lives in the Sahara desert where it is exposed to extreme temperatures up to 70° C. In other words, the organism is considered as a thermophile. Until now the genome remains unknown but the fact that C. fortis provides heat stable proteins makes it very interesting in the field of protein studies and maybe even therapeutical research later on. This thesis focuses on trying to find genes that are expressed in C. fortis. Different genes were chosen and capable primers designed. After fishing for the enzyme GAPDH a fragment was found and sequenced. The sequenc
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8

Basile, Walter. "Orphan Genes Bioinformatics : Identification and properties of de novo created genes." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-149168.

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Even today, many genes are without any known homolog. These "orphans" are found in all species, from Viruses to Prokaryotes and Eukaryotes. For a portion of these genes, we might simply not have enough data to find homologs yet. Some of them are imported from taxonomically distant organisms via lateral transfer; others have homologs, but mutated beyond the point of recognition. However, a sizeable fraction of orphan genes is unambiguously created via "de novo" mechanisms. The study of such novel genes can contribute to our understanding of the emergence of functional novelty and the adaptation
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9

Riaño-Pachón, Diego Mauricio. "Identification of transcription factor genes in plants." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/2700/.

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In order to function properly, organisms have a complex control mechanism, in which a given gene is expressed at a particular time and place. One way to achieve this control is to regulate the initiation of transcription. This step requires the assembly of several components, i.e., a basal/general machinery common to all expressed genes, and a specific/regulatory machinery, which differs among genes and is the responsible for proper gene expression in response to environmental or developmental signals. This specific machinery is composed of transcription factors (TFs), which can be grouped int
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10

van, Heel David Alexander. "Identification of inflammatory bowel disease susceptibility genes." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249199.

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11

Greenhalgh, D. A. "Identification of transforming genes in colon carcinoma." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370416.

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12

Shin, Donghun Alberola-Ila José. "Identification and characterization of endothelial specific genes /." Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-05232005-173743.

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13

Reitmann, Anandi. "Identification of pathogenicity genes in Phytophthora cinnamomi." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/79179.

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14

Bella, Husam E. H. "Identification of Susceptibility Genes in Keloid Scarring." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525664.

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15

Van, Hateren Nick. "Identification of genes involved in urogenital development." Thesis, University of Oxford, 2002. https://ora.ox.ac.uk/objects/uuid:a926f3b5-f968-4f85-9644-f4ad1e216fef.

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The mouse urogenital system comprises the gonads, mesonephroi, kidneys and adrenal glands. The indifferent gonad, or genital ridge, arises on the ventro-medial aspect of the mesonephros at approximately 10 days post coitum (dpc), and enlarges due to the influx of germ cells and migration of somatic cells from the coelomic epithelium and mesonephros. Male and female gonads are morphologically indistinguishable until 12.5 dpc when the expression of the testis-determining gene Sry in the gonadal supporting cell lineage results in the differentiation of Sertoli cells. This process initiates a casc
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16

Wang, Fuli. "Identification of tumor suppressor genes using the approach of gene inactivation test /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-798-7/.

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17

Vickers, Mark Adrian. "Identification and characterisation of genes surrounding the human #alpha#-globin gene cluster." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305423.

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18

Teng, Huajian. "Identification of signalling pathways regulating TBX2 gene expression and its target genes." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3151.

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Includes abstract.<br>Includes bibliographical references (leaves 83-97).<br>Members of the T-box family of transcription factors provide an important link between development and cancer. T-box factors play critical roles in embryonic development and results from recent studies suggest that they function in controlling cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular proces
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19

Zhang, Yu. "Identification and characterization of candidate genes for peach fruit shape." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666885.

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El fruit del préssec deriva de l'ovari madur, que es converteix en drupa. La seva forma pot variar entre rodona i plana, adquirint algunes formes intermèdies com la forma aplanada. En el préssec, el fruit pla (anomenat paraguaià) és causat per un al·lel parcialment dominant que ha d'estar en heterocigosis (Ss), mentre que els fruits d'arbres homozigots (SS) avorten poques setmanes després del quallat del fruit. Investigacions anteriors han identificat un marcador SSR (UDP98-412) altament associat al caràcter i que és adequat per a la seva utilització en selecció assistida per marcadors (SAM).
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20

Esquerdo, Barragan Mariona. "Identification of deubiquitinating enzyme genes relevant for the regulation of retina-specific genes." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/405564.

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Protein post-translational modifications are regulatory mechanisms that cells use in response to intra- and extracellular signals. These signals modulate a panoply of conjugating enzymes that modify proteins post-translationally by the conjugation of a small functional group or peptide. The consequences of these modifications are very diverse, but they all present a common feature: they shift protein fate, localization or function. Besides, in the case of covalent protein modifications, such as ubiquitination, these regulatory mechanisms are reversible and dynamic. In mammals, only two E1 and
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21

Swallow, Mark Richard. "Gene expression in developing maize spikelets : studies in the identification of meiotic genes." Thesis, Royal Holloway, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363124.

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22

Baghdoyan, Sandrine. "Identification de genes de reponse aux cytokines par la technique du gene trap." Paris 7, 2000. http://www.theses.fr/2000PA077008.

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Le gm-csf (granulocyte-macrophage colony stimulating factor), l'interleukine-3 et l'interleukine-5 sont trois cytokines assurant communement la survie, la proliferation, la differenciation et l'activation de cellules hematopoietiques progenitrices et matures. Dans le but de mieux caracteriser leurs fonctions respectives et de comprendre les mecanismes moleculaires qui en sont a l'origine, nous avons mis au point une strategie permettant le piegeage de leurs genes cibles par l'utilisation du vecteur de gene trap rosageo dans les cellules progenitrices humaines tf-1. Nous avons mis en evidence d
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23

Bentil, Ekua Fesuwa. "Identification of Differentially Expressed Genes and Gene Sets Using a Modified Q-Value." Thesis, North Dakota State University, 2014. https://hdl.handle.net/10365/27313.

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Gene expression technologies allow expression levels to be compared across treatments for thousands of genes simultaneously. Statistical methods exist for identifying differentially expressed (DE) genes and gene sets while controlling multiple testing error. Most methods do not take into account the distribution of effect sizes or the overrepresentation of observed patterns. This paper compares a recently proposed modified q-value method that takes into account such patterns to a traditional q-value method for experiments with three treatments. The results of simulation studies performed sugge
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24

Krajmalnik-Brown, Rosa. "Genetic Identification of Reductive Dehalogenase Genes in Dehalococcoides." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11642.

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Chloroethenes such as tetrachloroethene (PCE), trichloroethene (TCE), dichloroethene (DCE) and vinyl chloride (VC), are major contaminants in subsurface systems threatening water quality and human health. Under anaerobic conditions, PCE and TCE can be reductively dechlorinated to ethene. Recent findings indicate that members of the Dehalococcoides group are responsible for ethene formation at chloroethene-contaminated sites. Dehalococcoides species exhibit diverse dechlorination activities, but share highly similar 16S rRNA genes. Hence, additional gene targets that go beyond the 16S rRNA
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25

Aktas, Yasemin. "Identification Of The Genes Involved In &amp." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/3/1252857/index.pdf.

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Soils in many agricultural areas have high pH, resulting in low availability of zinc and iron. Plants grown on such soils suffer from either Zn or Fe deficiency or both. The efficient plant genotypes grown normally in calcerous soils were found to evolve some strategies to acquire the iron which is in insoluble form. Iron efficient graminaceous monocots release iron chelating substances, mugineic acid family phytosiderophores (MAs), in response to iron deficiency stress. Several researchers have suggested that phytosiderophores also can play role in grass Zn nutrition and thus it may b
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26

Lin, Dong. "Identification of metastasis-associated genes in prostate cancer." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/24145.

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Metastasis is thought to be based on genetic and epigenetic alterations. The mechanisms underlying prostate cancer metastasis are not clear. Studies aimed at identifying genes with key roles in this process have been impeded by lack of clinically relevant models. The heterogeneity of primary prostate cancer specimens from patients, consisting of non-metastatic and metastatic subpopulations, hampers identification of metastasis-associated genes by direct comparison of primary and secondary cancers. To overcome such hurdles, metastatic and non-metastatic tumor sublines have been developed from o
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27

Vitos, Gabriella. "Identification and characterization of organotin inducible bacterial genes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80893.

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Organotin compounds are used for a variety of applications including antifouling paints for ship hulls, wood preservatives, and UV stabilizers in plastics. When they are released into aquatic environments, they easily accumulate in various marine organisms. Organotin compounds are considered endocrine disrupting chemicals since numerous marine organisms exhibit sexual abnormalities when exposed to dibutyltin. Singe certain bacteria show resistance to these compounds, we screened for genes that are induced by organotins. 3000 Escherichia coli clones were genetically engineered to contain
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Taylor, Jennifer M. "Approaches to the identification of genes for schizophrenia /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17111.pdf.

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29

Shin, Jung-Bum. "Identification of genes involved in sensory neuron mechanotransduction." [S.l. : s.n.], 2002. http://www.diss.fu-berlin.de/2003/68/index.html.

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30

To, Minh Dong. "Identification of transcriptionally deregulated genes in breast cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34057.pdf.

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31

Melin, Malin. "Identification of Candidate Genes in Four Human Disorders." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7344.

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32

Reid, Sarah Louise. "Identification and characterisation of wilms tumour susceptibility genes." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498326.

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33

Yu, Manda, and 余文迪. "Identification and characterization of ethylene receptor genes inrice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B30727546.

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34

Shah, Bindiya. "Identification of genes encoding secreted proteins of schistosomes." Thesis, University of York, 2000. http://etheses.whiterose.ac.uk/9801/.

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35

Griffiths, Jayne. "Identification of GA regulated genes in Arabidopsis thaliana." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442277.

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36

Shalom, Gil. "Identification of macrophage-induced genes in Burkholderia pseudomallei." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251370.

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37

Jowett, Jemma. "The identification and characterisation of AXR3-interacting genes." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423736.

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38

Chioza, Barry Andrew. "Identification of genes involved in idiopathic generalised epilepsy." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397656.

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39

Jeffress, Mara L. "Identification of putative Plasmodium falciparum mefloquine resistance genes /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5101.

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40

Beolchi, Patrizia. "Identification of genes involved in reprogramming-induced senescence." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44980.

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Senescence is a state of irreversible growth arrest first described in human fibroblasts when they undergo serial passage in vitro. Senescence can also occur in response to different stresses, such as replicative exhaustion, DNA damage or overexpression of oncogenes. The growth arrest associated with senescence is implemented by the activation of the p53/p21Cip1 and p16INK4a/Rb pathways. The expression in somatic cells of a combination of pluripotency-associated transcription factors, Oct4, Sox2, Klf4 and cMyc (OSKM) has been shown to generate embryonic stem cell-like cells termed induced plur
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41

Sundaramoorthi, Hemalatha. "Identification of Hox Genes Controlling Thrombopoiesis in Zebrafish." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822768/.

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Thrombocytes are functional equivalents of mammalian platelets and also possess megakaryocyte features. It has been shown earlier that hox genes play a role in megakaryocyte development. Our earlier microarray analysis showed five hox genes, hoxa10b, hoxb2a, hoxc5a, hoxc11b and hoxd3a, were upregulated in zebrafish thrombocytes. However, there is no comprehensive study of genome wide scan of all the hox genes playing a role in megakaryopoiesis. I first measured the expression levels of each of these hox genes in young and mature thrombocytes and observed that all the above hox genes except hox
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Travis, Kristina. "Identification of Novel Developmental Genes in Streptomyces Coelicolor." Otterbein University Distinction Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=otbndist16204640123321.

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43

Casanueva, Ana. "Identification of Bacteroides genes involved in Metronidazole resistance." Doctoral thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/4246.

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Includes bibliographical references (leaves [123]-141).<br>Bacteroides species are Gram-negative obligate anacrobes that live in the gastrointestinal tract of mammals and are thought to account for approximately 30% of the colonic microbiota. Certain Bacteroides species, such as B. fragilis and to a lesser extent B. thetaiotaomicron, can become opportunistic pathogens and cause severe infection. The antibiotic of choice for treating such infections is metronidazole, a DNA damaging agent. Metronidazole enters the bacterial cell as an inert prodrug, and is activated by cellular reduction into a
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44

Kotian, Shweta. "Identification of Novel Genes in BRCA1-Regulated Pathways." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366341897.

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Archacki, Stephen R. "MOLECULAR IDENTIFICATION OF NOVEL GENES ASSOCIATED WITH ATHEROSCLEROSIS." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1310652996.

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46

Wu, Yu. "Identification and Functional Characterization of Adipogenesis-related Genes." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1229546422.

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47

Neugebauer, Kerri Allison. "Identification of wheat genes induced by Puccinia triticina." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/34465.

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Doctor of Philosophy<br>Department of Plant Pathology<br>Harold N. Trick<br>Bread wheat (Triticum aestivum L.) is an important staple crop for 35% of the world’s population. One economically important pathogen of wheat is Puccinia triticina, the causal agent of leaf rust, can cause up to 50% yield loss during epidemics. Despite the lack of an alternate host to complete the sexual stages, P. triticina still has variation within the population, which can make achieving durable resistance difficult. This study aims to gain a better understanding of the P. triticina-wheat interaction by identifyin
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48

Shepherd, Jason. "The identification of plant calmodulin binding protein genes." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/14408.

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Ca<SUP>2+</SUP> is a frequently utilised second messenger in higher plants. Calmodulin is a small, highly conserved, multi-site receptor for Ca<SUP>2=</SUP>, which interacts with a large number of downstream effector proteins. Calmodulin binding proteins (CBPs) do not have a highly conserved binding domain, and interact with calmodulin in an unusual fashion involving both a hydrophobic surface and charged domains. A number of techniques to isolate CBPs from plants were used. Techniques based on DNA homology suffer from the extreme lack of conservation between calmodulin binding domains. Other,
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Reis, Vânia Isabel Gonçalves Pereira dos. "Identification of genes differentially expressed in breast cancer." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1095.

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Breast cancer comprises heterogeneous tumors with different clinical characteristics, disease courses, and responses to specific treatments. Moreover, breast carcinomas result mainly from the accumulation of genetic and epigenetic alterations in epithelial cells of mammary gland. The identification of novel genes differentially expressed in breast cancer has important implications in understanding the molecular mechanisms underlying breast tumorigenesis, and developing new diagnostic and therapeutic targets. Therefore, the aim of this work was to identify genes differentially expressed in the
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50

Erten, Mehmet Sinan. "Network Based Prioritization of Disease Genes." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1258743578.

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Thesis(M.S.)--Case Western Reserve University, 2009<br>Title from PDF (viewed on 2010-01-28) Department of Electrical Engineering and Computer Science -- Computer and Information Sciences Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
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