Books: 'Genes, Modifier'

1

Pechan, Paul. Genes on the menu: Facts for knowledge-based decisions. Berlin: Springer, 2005.

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2

Genes for Africa: Genetically modified crops in the developing world. Lansdowne: UCT Press, 2002.

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3

Holden, J. H. W. Genes, crops, and the environment. Cambridge: Cambridge University Press, 1993.

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4

Eat your genes: How genetically modified food is entering our diet. 2nd ed. London: Zed Books Ltd., 2003.

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5

Eat your genes: How genetically modified food is entering our diet. New York: Zed Books Ltd, 1998.

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6

Nottingham, Stephen. Eat your genes: How genetically modified food is entering our diet. Marrickville: Choice Books, 1999.

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7

A consumer's guide to GM food: From green genes to red herrings. Oxford: Oxford University Press, 2000.

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8

Genetically modified organisms and genetic engineering in research and therapy. Basel: Karger, 2012.

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9

Piguet, Pascale, and Philippe Poindron. Genetically modified organisms and genetic engineering in research and therapy. Basel: Karger, 2012.

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10

de, Vries G., ed. Genes on the menu: Facts for knowledge-based decisions. Berlin: Springer, 2005.

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11

Odundo, Samuel Gudu. From genes to genetically modified crops: The future of food production, sustainable environment, and human health in Africa. Eldoret, Kenya: Moi University Press, 2007.

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12

Odundo, Samuel Gudu. From genes to genetically modified crops: The future of food production, sustainable environment, and human health in Africa. Eldoret, Kenya: Moi University Press, 2007.

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13

1935-, Friedmann Theodore, ed. Gene doping in sports: The science and ethics of genetically modified athletes. Amsterdam: Elsevier Academic Press, 2006.

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14

1955-, Zhu Yang, ed. Modern biotechnology: Panacea or new Pandora's box? Wageningen, the Netherlands: Wageningen Academic Pubishers, 2011.

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15

Gene transfer to animal cells. Abingdon, Oxon: Garland Science/BIOS Scientific Publishers, 2005.

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16

Stewart, C. Neal. Plant transformation technologies. Ames, Iowa: Wiley-Blackwell, 2011.

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17

Biopharmaceuticals in plants: Toward the next century of medicine. Boca Raton: Taylor & Francis, 2010.

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18

Houdebine, Louis-Marie. Animal transgenesis and cloning. Chichester, UK: John Wiley & Sons, 2003.

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19

Symposium on Transgenic Technology in Medicine and Agriculture (1988 National Institutes of Health). Transgenic animals: Proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture sponsored by the Center for Population Research, National Institute of Child Health and Human Development held at the National Institutes of Health, Bethesda, Maryland, December 12-15, 1988. Boston: Butterworth-Heinemann, 1991.

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20

Health), Symposium on Transgenic Technology in Medicine and Agriculture (1988 National Institutes of. Transgenic animals: Proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture. Boston: Butterworth-Heinemann, 1991.

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21

H, Duckworth Donna, ed. Molecular biology in clinical medicine. New York: Elsevier, 1991.

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22

1932-, Maclean Norman, ed. Animals with novel genes. Cambridge: Cambridge University Press, 1994.

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23

1945-, Brunk Conrad G., and Coward Harold G, eds. Acceptable genes?: Religious traditions and genetically modified foods. Albany: State University of New York Press, 2009.

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24

Burghes, Arthur H. M., and Vicki L. McGovern. Spinal Muscular Atrophy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0034.

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Spinal muscular atrophies affect the lower motor neuron. The most common SMA maps to 5q is an autosomal recessive disorder. SMA is caused by loss or mutation of the SMN1 gene and retention of the SMN2 gene, and these genes lie in a complex area of the genome. Mild missense alleles of SMN1 work to complement SMN2 to give function and therapeutics that restore SMN levels are in clinical testing. Modifiers that lie outside the SMN gene locus and influence severity clearly exist, but what they are remains unknown as do the critical genes affected by SMN deficiency.

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25

Divan, Aysha, and Janice A. Royds. 6. Genetic engineering. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723882.003.0006.

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Gene-cloning processes enable us to produce large amounts of a DNA sequence so that its function can be studied. These technologies can also be applied in medicine and agriculture to genetically engineer production of biological proteins or whole organisms with new or modified traits. At the heart of these applications is the capability to produce recombinant proteins from cloned genes in host cells. ‘Genetic engineering’ outlines some of these applications: recombinant pharmaceuticals, monoclonal therapeutic antibodies, recombinant protein vaccines, gene therapy, and genetically modified foods. It also considers some of the concerns with these applications.

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26

Thomson, Jennifer A. Genes for Africa: Genetically Modified Crops in the Developing World. Juta Academic, 2004.

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27

Monteggia, Lisa M., and Wei Xu. Methods for In Vivo Gene Manipulation. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0004.

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Recent advances in mouse genetics have opened many new avenues of research in which to explore gene function in the brain, and contributions to the pathophysiology and treatment of psychiatric disorders. The use of the mouse to explore gene function has contributed a better understanding of the role of specific genes in the nervous system including their influence on neural circuits and complex behavior.This chapter explores current approaches to manipulate gene function in a mouse. Genetically modified mice allow for the investigation of a particular gene in vivo. The approaches discussed highlight recent advances to specifically overexpress or disrupt a specific gene of interest in the brain. We also highlight viral-mediated gene transfer approaches to allow for spatial and temporal control of gene function.

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28

Glowing Genes: A Revolution In Biotechnology. Prometheus Books, 2005.

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29

W, Fox Michael. Killer Foods: When Scientists Manipulate Genes, Better is Not Always Best. The Lyons Press, 2004.

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30

Geza, Hrazdina, ed. Use of agriculturally important genes in biotechnology. Amsterdam: IOS Press, 2000.

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31

Biloshytsky, Vadym, and Roman Cregg. Pioneering use of gene therapy for pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0083.

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The landmark paper discussed in this chapter is ‘Gene therapy for pain: Results of a Phase I clinical trial’, published by Fink et al. in 2011. In this study, the first of its kind, researchers studied the efficacy and safety of a modified herpes simplex virus (HSV) vector used to deliver PENK, which encodes proenkephalin, which is cleaved into the enkephalin peptides Met-enkephalin and Leu-enkephalin, which induce analgesia by acting on opioid receptors. The development of the HSV vector was based in part on results studies in which adenovirus, adeno-associated virus, or non-viral vectors were used to overexpress genes. Overexpression of a variety of large molecules leads to a reduction in pain-related behaviour in animals. Gene therapy in the treatment of chronic pain seems to offer a promising alternative to systemic or highly invasive therapies. However, additional research is needed to determine the safety, effectiveness, and cost-efficiency of this approach.

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32

Como Tus Genes / Eat Your Genes: Como los Alimentos Transgenicos estan en Nuestra Dieta / How Genetically Modified Food is Entering Our Diet (Paidos Controversias / Paidos Contraversies). 2nd ed. Ediciones Paidos Iberica, 2004.

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33

T, DeVita Vincent, Hellman Samuel, and Rosenberg Steven A, eds. Biologic therapy of cancer. 2nd ed. Philadelphia: Lippincott, 1995.

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34

Gujar, G., Y. Andi Trisyono, and Mao Chen, eds. Genetically Modified Crops in Asia Pacific. CSIRO Publishing, 2021. http://dx.doi.org/10.1071/9781486310913.

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Meeting future food needs without compromising environmental integrity is a central challenge for agriculture globally but especially for the Asia Pacific region – where 60% of the global population, including some of the world’s poorest, live on only 30% of the land mass. To guarantee the food security of this and other regions, growers worldwide are rapidly adopting genetically modified (GM) crops as the forerunner to protect against many biotic and abiotic stresses. Asia Pacific countries play an important role in this, with India, China and Pakistan appearing in the top 10 countries with acreage of GM crops, primarily devoted to Bt cotton. Genetically Modified Crops in Asia Pacific discusses the progress of GM crop adoption across the Asia Pacific region over the past two decades, including research, development, adoption and sustainability, as well as the cultivation of insect resistant Bt brinjal, drought-tolerant sugarcane, late blight resistant potato and biotech rice more specific to this region. Regulatory efforts of the Asia Pacific member nations to ensure the safety of GM crops to both humans and the environment are also outlined to provide impetus in other countries initiating biotech crops. The authors also probe into some aspects of gene editing and nanobiotechnology to expand the scope into next generation GM crops, including the potential to grow crops in acidic soil, reduce methane production, remove poisonous elements from plants and improve overall nutritional quality. Genetically Modified Crops in Asia Pacific provides a comprehensive reference not only for academics, researchers and private sectors in crop systems but also policy makers in the Asia Pacific region. Beyond this region, readers will benefit from understanding how GM crops have been integrated into many different countries and, in particular, the effects of the take-up of GM cropping systems by farmers with different socioeconomic backgrounds.

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35

James, Edward. Character. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252039324.003.0005.

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This chapter examines the way in which Bujold creates and presents character and personality. It focuses on depth and complexity of Bujold's characterization, with particular discussion of the relationship between Miles and his brother Mark, and between Miles and his cousin Ivan, in the Vorkosigan books. Bujold presents character and personality as created by culture, by nurture, and by experience. Genes, of course, remain at the root; and we are in a universe in which genes can be modified, before and after birth. Bujold creates character in a number of ways, but above all through two means: the choice of focalization and the description of people's interrelationships.

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36

Fathman, C. Garrison. Biologic and Gene Therapy of Autoimmune Disease (Current Directions in Autoimmunity). S. Karger AG (Switzerland), 2000.

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37

Transgenic animal models in biomedical research: Proceedings of a Symposium held at the National Institutes of Health, Bethesda, Maryland, November 4-5, 1991. Washington, DC: American Registry of Pathology, Armed Forces Institute of Pathology, 1992.

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38

Gene Doping in Sports, Volume 51: The Science and Ethics of Genetically Modified Athletes (Advances in Genetics). Academic Press, 2006.

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39

(Editor), Angela J. Schneider, and Theodore Friedmann (Series Editor), eds. Gene Doping in Sports, Volume 51: The Science and Ethics of Genetically Modified Athletes (Advances in Genetics). Academic Press, 2006.

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40

Thomson, Jennifer. GM Crops and the Global Divide. CSIRO Publishing, 2021. http://dx.doi.org/10.1071/9781486312665.

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Attitudes to GM crops continue to generate tension, even though they have been grown commercially for over 20 years. Negative sentiment towards their development limits their adoption in Western countries, despite there being no evidence of harm to human health. These unfounded concerns about genetically modified crops have also inhibited uptake in many countries throughout Africa and Asia, having a major impact on agricultural productivity and preventing the widespread cultivation of potentially life-saving crops. GM Crops and the Global Divide traces the historical importance that European attitudes to past colonial influences, aid, trade and educational involvement have had on African leaders and their people. The detrimental impact that these attitudes have on agricultural productivity and food security continues to be of growing importance, especially in light of climate change, drought and the potential rise in sea levels – the effects of which could be mitigated by the cultivation of GM and gene-edited crops. Following on from her previous books Genes for Africa, GM Crops: The Impact and the Potential and Food for Africa, Jennifer Thomson unravels the reasons behind these negative attitudes towards GM crop production. By addressing the detrimental effects that anti-GM opinions have on nutrition security in developing countries and providing a clear account of the science to counter these attitudes, she hopes to highlight and ultimately bridge this global divide.

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41

Han, Shihui. A culture–behavior–brain-loop model of human development. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198743194.003.0008.

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Chapter 8 introduces a culture–behavior–brain (CBB)-loop model of human development based on cultural neuroscience findings, and proposes a new framework for understanding human development regarding both human phylogeny and lifespan ontogeny. This model posits that culture shapes the brain by contextualizing behavior, and the brain fits and modifies culture via behavioral influences. Genes provide a fundamental basis for and interact with the CBB loop at both individual and population levels. The CBB-loop model advances our understanding of the dynamic relationships between culture, behavior, and the brain. Future brain changes owing to cultural influences are discussed based on the CBB-loop model.

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42

Principles and Practice of the Biologic Therapy of Cancer. 3rd ed. Lippincott Williams & Wilkins, 2000.

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43

Angelakis, Emmanouil, and Didier Raoult. Scrub typhus. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0013.

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Bacteria of the genus Rickettsia are obligate intracellular rods that retained basic fuchsin when stained by the method of Gimenez. This genus has long been used as a generic term of small intracellular bacteria. However, taxonomic progress made over the last years has deeply modified the definition of “rickettsia”. As a result, in 1995 the position of R. tsutsugamushi has reclassified from the genus Rickettsia into a separate new genus, Orientia (Tamura et al. 1995).Scrub typhus, also known as ‘tsutsugamushi fever’, occurs only in Asia and is a chigger-borne zoonosis. The disease is acute, febrile, potentially fatal and has been known for centuries in China where it was probably described as early as in the fourth century BC (Parola and Raoult 2006). These last years this infection has been re-emerging because of descriptions of strains of O. tsutsugamushi with reduced susceptibility to antibiotics and of the surprising interactions between scrub typhus and the human immunodeficiency virus (HIV). It is estimated that more than a million cases of scrub typhus are transmitted annually in Asia and more than a billion people are at risk (Rosenberg 1997).

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44

Altered Genes, Twisted Truth: How the venture to genetically engineer our food has subverted science, corrupted government, and systematically deceived the public. Salt Lake City, UT: Clear River Press, 2015.

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45

P, Workman, ed. New approaches in cancer pharmacology: Drug design and development. Berlin: Springer-Verlag, 1992.

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46

Rulicke, T. Transgene, Transgenese, Transgene Tiere: Methoden Der Nichthomologen Dna-Rekombination. S Karger Pub, 2001.

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47

Thursfield, Rebecca, Chris Orchard, Rosanna Featherstone, and Jane C. Davies. Future treatments. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0013.

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There are only a relatively limited armoury of drugs, the majority of which are aimed at downstream symptoms of cystic fibrosis. Therapies targeting the basic defect in CF as well as continued availability of more conventional drugs are required. Progress in gene therapy has been limited by the significant barriers to gene transfer of the CF lung, but the UK is hosting a large repeated dose trial of nebulized non-viral gene therapy designed around clinically meaningful outcomes. The UK CF Gene Therapy Consortium is also seeking to develop a promising modified lentiviral approach, although this is some years off. Perhaps the exciting development of recent decades has come from small molecule CFTR modulators, driven by an understanding of basic pathophysiological mechanisms. Ivacaftor is the first drug to be licensed, having proved itself highly clinically efficacious in patients with the class-3 gating mutation G551D. The trial pipeline seeks to expand indications for this and to explore the potential of Phe508del correctors. Finally, a number of anti-inflammatory and anti-infective strategies are being pursued. The emerging global problem of antibiotic resistance is leading to exciting alternatives such as biofilm disruption and bacteriophage to be explored.

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48

Hodgkins, Christopher. Settlers in New Worlds. Edited by Andrew Hiscock and Helen Wilcox. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199672806.013.31.

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Early modern colonial survival meant that imaginative writings about settlers in new worlds outnumbered imaginative writings by those settlers; yet new world settlers did leave literary artefacts of their interpretive communities. Writing about new worlds tended to fire the fancy, either in fantastic exploration narratives, fabulous colonial prospecti, reflective essays, or in the more outright fictions of dramatic and utopian literature, and of lyric and epic poetry. Writing in and from new worlds was often more quotidian, with nonfiction prose genres like ships’ logs, company reports, personal letters, spiritual diaries, and sermons predominating with a sprinkling of original poetry, proverb, and song. Old genres were modified, and new ones born, by necessity and invention: not only the traveller’s tale and ‘utopian’ fiction, but also the conquest story, the atrocity exposé, the settlers’ covenant, the captivity and conversion narrative, and the extended Eucharistic meditation and puritan jeremiad—and the novel.

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49

Yang, Jin, Pei Han, Wei Li, and Ching-Pin Chang. Epigenetics and post-transcriptional regulation of cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0032.

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Cardiac organogenesis requires the control of gene expression at distinct developmental windows in order to organize morphogenetic steps in the correct sequence for heart development. This is facilitated by concerted regulation at three levels: chromatin, transcription, and post-transcriptional modifications. Epigenetic regulation at the chromatin level changes the chromatin scaffold of DNA to regulate accessibility of the DNA sequence to transcription factors for genetic activation or repression. At the genome, long non-coding RNAs work with epigenetic factors to alter the chromatin scaffold or form DNA-RNA complexes at specific genomic loci to control the transcription of genetic information. After RNA transcription, the expression of genetic information can be further modified by microRNAs. Each layer of gene regulation requires the participation of many factors, with their combinatorial interactions providing variations of genetic expression at distinct pathophysiological phases of the heart. The major functions of chromatin remodellers and non-coding RNAs are discussed.

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50

Wooton, Marianne, and Claudia Castellani. Crustacea: Copepoda. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199233267.003.0022.

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This chapter describes the taxonomy of copepods. Copepods are small aquatic crustaceans and are considered to be one of the most abundant and diverse multi-cellular organisms on earth. Populating a wide range of aquatic habitats, from the deep ocean floor to high Himalayan freshwater lakes, copepods have many free-living as well as highly modified parasitic forms. The chapter covers their life cycle, ecology, and general morphology. It includes a section that indicates the systematic placement of the taxon described within the tree of life, and lists the key marine representative illustrated in the chapter (usually to genus or family level). This section also provides information on the taxonomic authorities responsible for the classification adopted, recent changes which might have occurred, and lists relevant taxonomic sources.

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Books on the topic 'Genes, Modifier'

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