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Dissertations / Theses on the topic 'Genesis of the novel'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Cristofaro, Brunella. "Neurotrophin-3 : a novel mediator of angiogenesis and arteriolar genesis." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520610.

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2

Kang, Kyoung-Lae. "Novel genres or generic novels considering Korean movies adapted from amateur Internet novels /." Connect to this title online, 2008. http://scholarworks.umass.edu/theses/96/.

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3

Stringer, Hillary. "Patrol: Excerpts From a Novel." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc700057/.

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The dissertation consists of a critical preface and excerpts from the novel Patrol. The preface explores how the novel Patrol utilizes characters that engage with tropes of the Romantic Genius in order to establish their subjectivity while navigating the standardizing mechanisms of twenty-first century information technologies. The preface analyzes how the rise of the organic food movement, the usage of biotech genetic engineering, and the tactics of Big Data-era marketing all inform the critical underpinnings of Patrol, situating the novel in conversation with works of fiction and nonfiction

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4

Solinas, Antonio. "Novel approaches in genetic analysis." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274529.

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5

Ranasinghe, Rohan T. "Novel techniques for genetic analysis." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430494.

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6

McCubbin, T. Paul. "Novel #Beta#-spectrin isoforms." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279964.

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7

Martin, Stephen Lewis. "Novel methods for mutagenesis." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302789.

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8

Entesarian, Miriam. "Molecular Genetic Studies of ALSG, Kostmann Syndrome and a Novel Chromosome 10 Inversion." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100598.

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In summary, this thesis presents the localisation and identification of genetic variants of which some are disease associated and some considered to be neutral. Knowledge of the basic mechanisms behind human disorders is important both from a biological and medical point of view. The thesis is based on four papers of which the first two clarify the genetic basis of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG is a rare disorder with high penetrance and variable expressivity characterized by dry mouth and eyes. In paper I, we located the ALSG gene to a 22 centiMorgan

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9

Bin, Kaderi Mohamed Arifin. "Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110371.

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The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. However, the search for more feasible prognostic markers in CLL is still being pursued. Recently, certain single nucleotide polymorphisms (SNPs) in the GNAS1, BCL2 and MDM2 genes and the RNA expression levels of the LPL, ZAP70, TCL1, CLLU1 and MCL1 genes were suggested as no

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10

Hu, Xiaotong, and 胡曉彤. "Novel IGH translocations in gastric non-Hodgkin's B-cell lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38688098.

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11

Brown, Gerald Francis. "Novel aspects of grass carp GHR gene regulation." Thesis, Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41897080.

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12

Catti, Federica. "4,5-dihydropyrazoles : novel chemistry and biological activity." Thesis, St Andrews, 2007. http://hdl.handle.net/10023/351.

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13

Stolk, Megan. "Characterisation of novel TAC3 a d TACR3 gene variants and polymorphisms in patients with pre-eclampsia /." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/1748.

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Thesis (MSc (Genetics))—University of Stellenbosch, 2007.<br>In South Africa, pre-eclampsia is the second highest cause of maternal deaths. The incidence of this disease in the Western Cape alone is 6.8% and places a large burden of health care facilities. The placenta and implantation thereof is thought to play the most significant role in the onset of this disease. Among the many theories for its aetiology, is the acknowledged two - stage theory. This is based on evidence that pre-eclamptic placentas demonstrate altered remodelling and invasion into the uterine endometrium and myometriu

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14

Williamson, Phillip C. "A Novel Mechanism for Site-Directed Mutagenesis of Large Catabolic Plasmids Using Natural Transformation." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2828/.

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Natural transformation is the process by which cells take up DNA from the surrounding medium under physiological conditions, altering the genotype in a heritable fashion. This occurs without chemical or physical treatment of the cells. Certain Acinetobacter strains exhibit a strong tendency to incorporate homologous DNA into their chromosomes by natural transformation. Transformation in Acinetobacter exhibits several unique properties that indicate this system's superiority as a model for transformation studies or studies which benefit from the use of transformation as an experimental method

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15

梁嘉玲 and Ka-ling Leung. "Novel molecular targets of Burkholderia pseudomallei." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31224726.

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16

Leung, Ka-ling. "Novel molecular targets of Burkholderia pseudomallei /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23440144.

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17

López, Vernaza Manuel A. "Genetic screen for novel polycomb group (PcG) genes and targets in Arabidopsis thaliana." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4386.

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Polycomb Group (PcG) proteins are responsible for post-transcriptional modifications in histone tails leading to chromatin condensation and changes in gene expression. In Arabidopsis thaliana, curly leaf (CLF) is a member of the Polycomb Reporssive Complex 2 (PRC2), which cnfers a repressive epigenetic mark, namely trimethylation of histone H3 at lysine 27 (H3K27me3). In the clf mutant, the expression of the floral organ identity gene AGAMOUS (AG) is derepressed in vegetative stages and coincides with loss of H3K27me3 at the AG locus. Recent whole genome prfiling studies have suggested that Pc

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18

Mansfield, Robert Patrick William. "Developments in genetic engineering of novel acetogens." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51833/.

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The development of processes for sustainable energy and chemical production is of great importance for the health of our planet. Utilising suitable feedstocks such as renewable resources and existing waste streams is central to making such processes a reality. Microorganisms can be employed in the processing of a diverse range of such feedstocks, offering unique routes of production for useful and valuable chemical products. Acetogenic organisms, capable of fermenting single carbon (C1) feedstocks are especially interesting from the perspective of industrial application. Their natural metaboli

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19

Crompton, Michael. "Edison : a novel model of otitis media." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:1e13bb89-893e-434e-acc1-f39d0563d6cb.

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Otitis media (OM) is characterised by inflammation of the middle ear and is a common cause of conductive hearing impairment that places a substantial social, medical and economic burden on healthcare systems globally. Despite the importance of the disease, the aetiology of chronic middle ear inflammatory disease remains poorly understood. The development and persistence of chronic OM is multi-factorial with a significant genetic component. A new mouse model of chronic OM, edison, was generated by N-ethyl-N-nitrosourea (ENU) mutagenesis and discovered in a recessive screen at MRC Harwell. Homoz

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20

Kelly, Emma Naomi. "PITAIRE : a novel CDK-related protein kinase." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263563.

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21

Liu, Leah. "Novel Regulators of Liver Development and Metabolism." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463147.

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Chronic liver diseases such as non-alcoholic fatty liver disease and alcoholic liver disease are significant health concerns worldwide. Despite knowledge of disease features and environmental causes, we lack understanding of the genetic factors and molecular mechanisms that can be targeted for liver disease therapeutics. Many of these factors are also essential during embryonic development and organogenesis. Here, we use liver development in zebrafish as a model and paradigm for the discovery of regulators impacting liver disease pathogenesis. A chemical screen in zebrafish identified the endo

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22

Altemose, Nicolas Frank. "Novel genetic and molecular properties of meiotic recombination protein PRDM9." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:1afe17c3-5f75-4166-8697-7da1471a5230.

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Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enabling offspring to inherit novel combinations of mutations, and ensuring even segregation of chromosomes into gametes. Recombination is initiated by programmed Double Strand Breaks (DSBs), the genomic locations of which are determined in most mammals by PRDM9, a rapidly evolving DNA-binding protein. In crosses between different mouse subspecies, certain Prdm9 alleles cause infertility in hybrid males, implying a critical role in fertility and speciation. Upon binding to DNA, PRDM9 deposits a histone

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23

Archacki, Stephen R. "MOLECULAR IDENTIFICATION OF NOVEL GENES ASSOCIATED WITH ATHEROSCLEROSIS." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1310652996.

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24

Jonnala, Ramakanth S. "Protein composition-functionality relationships using novel genetic lines." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/578.

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25

Iatan, Iulia. "Novel genetic and molecular regulation of HDL metabolism." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121170.

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Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Low levels of high-density lipoprotein cholesterol (HDL-C) constitute a major independent risk factor for CAD, influenced by a combination of genetic and environmental factors. In this thesis, we aimed to advance our understanding of the genetic regulation of HDL-C, through the identification and characterization of novel candidate genes, and to delineate the molecular mechanisms underlying HDL biogenesis, in the hopes of better elucidating the complexities of HDL metabolism. First, we examined whether var

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26

Keylock, Annette Ai Lin. "Novel genetic causes of cerebral and systemic vasculopathies." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10048485/.

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Vasculopathies are a varied group of disorders that affect the vascular tree resulting in arterial stenosis or dilatation causing multi-organ ischaemia and significant cardiac and cerebral circulation complications. Commonly, vasculopathies present in infancy and segregate within families so a genetic cause is often suspected but not always identified by the current routinely available genetic tests in the UK National Health Service (NHS). Due to the overlapping phenotypes of these disorders genetic sequencing is required for accurate diagnosis and appropriate clinical intervention. In this th

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27

Chai, Shin Luen Chai. "Novel Genetic Modifiers in a Monogenic Cardiac Arrhythmia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1516618028568975.

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28

Hjorth-Hansen, Henrik. "Novel cytokines in growth control and bone disease of multiple myeloma." Doctoral thesis, Norwegian University of Science and Technology, Faculty of Medicine, 2001. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-315.

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<p>Myelomatose (benmargskreft) er en blodsyk dom som rammer ca 200 nordmenn årlig. Sykdommen kan ikke kureres og karakteriseres av symptomer som benmargssvikt og infeksjonstendenns, men kanskje først og fremst av sykelig nedbrytning av skjelettet. Pasientene rammes i høy utstrekning av benbrudd, hvirvelsammenfall og skjelettsmerter. Mekanismene for bennedbrytning og vekstkontroll står sentralt i avhandlingsarbeidet som består av fem artikler om cytokiners rolle i myelomatose. Cytokiner er signalsubstanser som benyttes i celle-celle-kommunikasjon. Det er sannsynligvis ubalanse av cytokiner som

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29

Maskos, Uwe. "A novel method of nucleic acid sequence analysis." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306792.

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30

Nichol, Richard Bradley. "A novel diacylglycerol-binding protein in Dictyostelium discoideum." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249562.

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31

Read, Tara. "Elucidating a novel gene associated with myoclonus dystonia." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28248.

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Myoclonus Dystonia (MD) is an autosomal dominant disease with high but incomplete penetrance and is characterized by both involuntary myoclonic jerks and dystonic posturing. Our group has found that mutations within the epsilon sarcoglycan (SGCE) gene on chromosome 7q21 are associated with MD in 30-40% of affected individuals in 31 families studied, supporting the basis for genetic heterogeneity. Novel mutations have been found in SGCE by screening these families for point mutations and large deletions and duplications through the use of sequencing, high performance liquid chromatography (HPLC

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32

Omar, Ameen Abdulqader. "The Iraqi Kurdish novel, 1970-2011 : a genetic structuralist approach." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/24105.

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This thesis explores the emergence and development of the Iraqi Kurdish novel between 1970 and 2011, aiming to demonstrate that it engages with political discourses, and that the political situation influenced the themes and structural development of the novel. It will seek to elucidate why, when we examine the history of Kurdish literature over the last fifty years, the first point that may attract our attention is its emergence from the political events. Based on this notion the current study has been divided into three historical phases; 1970-1991, 1991-2003 and 2003-2011. A chapter has bee

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33

Vyas, Aditi. "Identification of Novel Stat92E Target Genes in Drosophila Hematopoiesis." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1450868635.

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34

Travis, Kristina. "Identification of Novel Developmental Genes in Streptomyces Coelicolor." Otterbein University Distinction Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=otbndist16204640123321.

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35

Robert, Stanley. "Functional characterisation of Polycomblike and a novel, chromosomal protein interactor from Drosophila melanogaster /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phr642.pdf.

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36

Lambert, Carol-Ann. "A novel marker technique : using miniature inverted-repeat transposable elements (MITEs) in combination with resistant gene analogues (RGAs)." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52117.

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Thesis (PhD)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Given the organisation of the maize genome as well as demands placed on the saturation of molecular linkage maps it would be desirable to identify informative molecular markers that is located or linked to genic rich areas. Sequences of gene products from different gene classes were investigated. Proteins containing a nucleotide binding site (NBS) and leucine-rich repeat (LRR) region comprise the largest class of disease resistance proteins. Resistant gene analogue (RGA) primers belonging to this specific class were derive

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37

Worthington, Jenny. "Radiation-controlled gene expression : a novel approach to oxygenation-dependent radiotherapy." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342528.

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38

McGregor, Nathaniel Wade. "The identification of novel susceptibility genes involved in anxiety disorders." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95859.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The etiology of anxiety disorders remains incompletely understood. Clear evidence for a genetic component has been proposed; however, there is also an increasing focus on environmental factors and the interaction between these and the genetic components that may mediate (anxiety) disorder pathogenesis. No single gene or genetic component has been explicitly identified as being involved in the development of anxiety disorders. This is most likely due to a number of reasons, which include, for example, the heterogeneity of anxiet

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39

Quinn, Bridget A. "Novel Therapeutic Strategies for Pancreatic Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4671.

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Pancreatic cancer is a devastating disease that leaves patients with a very poor prognosis and few therapeutic options. Many of the treatment options available are the same that have been used for almost 2 decades. There is a dire need for both novel treatments for this disease as well as novel strategies of treatment. This body of work will introduce and provide evidence in support of a novel combination therapy for pancreatic cancer treatment, a novel strategy of modifying currently used chemotherapeutics for pancreatic cancer therapy, and a novel transgenic preclinical mouse model of pancre

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40

Abu-Zayyad, Amineh Naji. "A novel non-spreading variant of transformed hamster fibroblasts." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360924.

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41

Harrison, Mark. "Studies on novel human DNA damage sensitive cell lines." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299863.

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42

Hacking, G. N. V. "Novel approaches towards the development of an HIV vaccine." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308246.

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43

Webb, Tania Elizabeth. "Cloning and characterisation of novel G protein-coupled receptors." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337086.

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44

Mansoorian, Neda. "Analysis of a novel Myb-like gene from soybean." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26969.

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This thesis reports the identification and characterization of a novel gene, named 7/2, from soybean (Glycine max L. Merrill). Genomic clones of 7/2 from two different cultivars, cvs Maple Arrow and Resnik were isolated and sequenced, and the sequences were compared to each other. These sequences were 100% identical. Alignment with a cDNA sequence from cv. Maple Arrow revealed the structure of the gene as having 6 exons and 5 introns. The full length cDNA contains an ORF of 798 by encoding a novel protein of 265 amino acids with a calculated molecular weight of 29.98 kDa. The conceptual 7/2 pr

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45

Kowalski, Paul Edward. "Novel genetic effects of a human endogenous retrovirus insertion." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34571.pdf.

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46

Anwar, Sabina Zareen. "Functional characterisation of synuclein-based novel genetic mouse models." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b14fc29e-2bc8-4a31-865b-f4ec0e0f6f2c.

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Synucleins are highly conserved presynaptic proteins with unknown function. α-synuclein plays a key role regulating dopamine homeostasis and is intimately involved in Parkinson’s disease (PD) pathogenesis. However, the normal/pathological role of α-synuclein remains unidentified. Studies exploring its function are limited as current transgenic mouse models do not fully recapitulate PD pathology. This thesis reports the functional characterisation of two novel synuclein-based mouse models. I report the molecular and functional characterisation of transgenic mouse lines with wild-typ

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47

Mattioli, Francesca. "Identification of novel genetic causes of monogenic intellectual disability." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ035/document.

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La déficience intellectuelle (DI) est une trouble du neuro développement caractérisée par une extrême hétérogénéité génétique, avec plus de 700 gènes impliqués dans des formes monogéniques de DI. Cependant un nombre important de gènes restent encore à identifier et les mécanismes physiopathologiques de ces maladies neuro développementales restent encore à comprendre. Mon travail de doctorat a consisté à identifier de nouvelles causes génétiques impliquées dans la DI. En utilisant différentes techniques de séquençage de nouvelle génération, j’ai pu augmenter le taux de diagnostic chez les patie

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48

Chan, Ernest Ricky. "Genetic Analysis of Novel Models of Thrombocytopenia and Leucopenia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1248212698.

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49

Alphey, Nina. "Modelling optimal strategies for novel genetics-based pest management." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:03656907-ff7d-4afd-a958-9262a200f318.

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Genetic transformation techniques for pest insects have enabled the development of novel methods to mitigate the enormous harm done by insects to human health (through transmission of diseases) and to agriculture (through damage to crops or livestock). I use mathematical modelling to analyse strategies using autocidal genetic constructs (dominant lethal genes that are repressible during mass-rearing); in parallel several research groups are developing the strains and the laboratory and field experimental work. Engineered insects would be released in large numbers and compete for mates, and the

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50

Arya, V. B. "Understanding the novel genetic mechanisms of congenital hyperinsulinaemic hypoglycaemia." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469326/.

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Background: Hyperinsulinaemic hypoglycaemia (HH) is characterized by unregulated secretion of insulin in the presence of hypoglycaemia. Mutations in nine different genes (ABCC8, KCNJ11, GLUD1, HNF4A, HNF1A, GCK, HADH, SLC16A1 and UCP2) have so far been identified as a cause of HH. Mutations in ABCC8 and KCNJ11, which encode the sulfonylurea receptor 1 (SUR1) and potassium inward-rectifying 6.2 (Kir6.2) subunits of ATP-sensitive potassium channel (KATP channel), are the most common cause of HH. At least two (possibly more) well-described histological subtypes are associated with HH: a focal for

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