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Dissertations / Theses on the topic 'Genetic algorithms – Statistical methods'

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Published: 4 June 2021

Last updated: 6 February 2022

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1

Czarn, Andrew Simon Timothy. "Statistical exploratory analysis of genetic algorithms." University of Western Australia. School of Computer Science and Software Engineering, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0030.

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[Truncated abstract] Genetic algorithms (GAs) have been extensively used and studied in computer science, yet there is no generally accepted methodology for exploring which parameters significantly affect performance, whether there is any interaction between parameters and how performance varies with respect to changes in parameters. This thesis presents a rigorous yet practical statistical methodology for the exploratory study of GAs. This methodology addresses the issues of experimental design, blocking, power and response curve analysis. It details how statistical analysis may assist the in

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2

Shen, Rujun, and 沈汝君. "Mining optimal technical trading rules with genetic algorithms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47870011.

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In recent years technical trading rules are widely known by more and more people, not only the academics many investors also learn to apply them in financial markets. One approach of constructing technical trading rules is to use technical indicators, such as moving average(MA) and filter rules. These trading rules are widely used possibly because the technical indicators are simple to compute and can be programmed easily. An alternative approach of constructing technical trading rules is to rely on some chart patterns. However, the patterns and signals detected by these rules are oft

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3

Barreau, Thibaud. "Strategic optimization of a global bank capital management using statistical methods on open data." Thesis, KTH, Matematisk statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273413.

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This project is about the optimization of the capital management of a French global bank. Capital management corresponds here to allocating the available capital to the different business units. In this project, I focus on the optimization of the allocation of the risk weighted assets (RWA) between some of the business units of the bank, as a representation of the allocated capital. Emphasis is put on the market and retail part of the bank and the first step was to be able to model the evolution of a business unit given an economic environment. The second one was about optimizing the distribut

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4

Larsen, Ross Allen Andrew. "Food Shelf Life: Estimation and Experimental Design." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1315.pdf.

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5

Herrington, Hira B. "A Heuristic Evolutionary Method for the Complementary Cell Suppression Problem." NSUWorks, 2015. http://nsuworks.nova.edu/gscis_etd/28.

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Cell suppression is a common method for disclosure avoidance used to protect sensitive information in two-dimensional tables where row and column totals are published along with non-sensitive data. In tables with only positive cell values, cell suppression has been demonstrated to be non-deterministic NP-hard. Therefore, finding more efficient methods for producing low-cost solutions is an area of active research. Genetic algorithms (GA) have shown to be effective in finding good solutions to the cell suppression problem. However, these methods have the shortcoming that they tend to produce a

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6

ZHANG, GE. "STATISTICAL METHODS IN GENETIC ASSOCIATION." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196099744.

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7

Valenzuela-Del, Rio Jose Eugenio. "Bayesian adaptive sampling for discrete design alternatives in conceptual design." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50263.

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The number of technology alternatives has lately grown to satisfy the increasingly demanding goals in modern engineering. These technology alternatives are handled in the design process as either concepts or categorical design inputs. Additionally, designers desire to bring into early design more and more accurate, but also computationally burdensome, simulation tools to obtain better performing initial designs that are more valuable in subsequent design stages. It constrains the computational budget to optimize the design space. These two factors unveil the need of a conceptual design methodo

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8

Rogers, Alex. "Modelling genetic algorithms and evolving populations." Thesis, University of Southampton, 2000. https://eprints.soton.ac.uk/261289/.

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A formalism for modelling the dynamics of genetic algorithms using methods from statistical physics, originally due to Pr¨ugel-Bennett and Shapiro, is extended to ranking selection, a form of selection commonly used in the genetic algorithm community. The extension allows a reduction in the number of macroscopic variables required to model the mean behaviour of the genetic algorithm. This reduction allows a more qualitative understanding of the dynamics to be developed without sacrificing quantitative accuracy. The work is extended beyond modelling the dynamics of the genetic algorithm. A cari

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9

Shar, Nisar Ahmed. "Statistical methods for predicting genetic regulation." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16729/.

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Transcriptional regulation of gene expression is essential for cellular differentiation and function, and defects in the process are associated with cancer. Transcription is regulated by the cis-acting regulatory regions and trans-acting regulatory elements. Transcription factors bind on enhancers and repressors and form complexes by interacting with each other to control the expression of the genes. Understanding the regulation of genes would help us to understand the biological system and can be helpful in identifying therapeutic targets for diseases such as cancer. The ENCODE project has ma

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10

Pittman, Jennifer L. "Adaptive splines and genetic algorithms for optimal statistical modeling." Adobe Acrobat reader required to view the full dissertation, 2000. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-23/index.html.

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11

Rattray, Magnus. "Modelling the dynamics of genetic algorithms using statistical mechanics." Thesis, University of Manchester, 1996. http://publications.aston.ac.uk/598/.

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A formalism for modelling the dynamics of Genetic Algorithms (GAs) using methods from statistical mechanics, originally due to Prugel-Bennett and Shapiro, is reviewed, generalized and improved upon. This formalism can be used to predict the averaged trajectory of macroscopic statistics describing the GA's population. These macroscopics are chosen to average well between runs, so that fluctuations from mean behaviour can often be neglected. Where necessary, non-trivial terms are determined by assuming maximum entropy with constraints on known macroscopics. Problems of realistic size are describ

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12

Shringarpure, Suyash. "Statistical Methods for studying Genetic Variation in Populations." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/117.

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The study of genetic variation in populations is of great interest for the study of the evolutionary history of humans and other species. Improvement in sequencing technology has resulted in the availability of many large datasets of genetic data. Computational methods have therefore become quite important in analyzing these data. Two important problems that have been studied using genetic data are population stratification (modeling individual ancestry with respect to ancestral populations) and genetic association (finding genetic polymorphisms that affect a trait). In this thesis, we develop

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13

Cheng, Lulu. "Statistical Methods for Genetic Pathway-Based Data Analysis." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/52039.

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The wide application of the genomic microarray technology triggers a tremendous need in the development of the high dimensional genetic data analysis. Many statistical methods for the microarray data analysis consider one gene at a time, but they may miss subtle changes at the single gene level. This limitation may be overcome by considering a set of genes simultaneously where the gene sets are derived from the prior biological knowledge and are called "pathways". We have made contributions on two specific research topics related to the high dimensional genetic pathway data. One is to propose

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14

Yung, Godwin Yuen Han. "Statistical methods for analyzing genetic sequencing association studies." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493313.

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Case-control genetic sequencing studies are increasingly being conducted to identify rare variants associated with complex diseases. Oftentimes, these studies collect a variety of secondary traits--quantitative and qualitative traits besides the case-control disease status. Reusing the data and studying the association between rare variants and secondary phenotypes provide an attractive and cost effective approach that can lead to discovery of new genetic associations. In Chapter 1, we carry out an extensive investigation of the validity of ad hoc methods, which are simple, computationally ef

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15

Lange, Christoph. "Generalized estimating equation methods in statistical genetics." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269921.

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16

Brunning, James Jonathan Jesse. "Alignment models and algorithms for statistical machine translation." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608922.

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17

Clark, Taane Gregory. "Statistical methods for finding associations in dense genetic regions." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413976.

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18

Ferreira, Teresa. "Statistical methods for modelling epistasis in genetic association studies." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543476.

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19

Su, Zhan. "Statistical methods for the analysis of genetic association studies." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:98614f8b-63fe-4fa1-9a24-422216ad14cf.

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One of the main biological goals of recent years is to determine the genes in the human genome that cause disease. Recent technological advances have realised genome-wide association studies, which have uncovered numerous genetic regions implicated with human diseases. The current approach to analysing data from these studies is based on testing association at single SNPs but this is widely accepted as underpowered to detect rare and poorly tagged variants. In this thesis we propose several novel approaches to analysing large-scale association data, which aim to improve upon the power offered

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20

Lin, Xinyi (Cindy). "Statistical Methods for High-Dimensional Data in Genetic Epidemiology." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11326.

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Recent technological advancements have enabled us to collect an unprecedented amount of genetic epidemiological data. The overarching goal of these genetic epidemiology studies is to uncover the underlying biological mechanisms so that improved strategies for disease prevention and management can be developed. To efficiently analyze and interpret high-dimensional biological data, it is imperative to develop novel statistical methods as conventional statistical methods are generally not applicable or are inefficient. In this dissertation, we introduce three novel, powerful and computationally

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21

Yi, Wan Kitty Yuen. "Statistical methods for the analysis of genetic association studies." Thesis, University of Kent, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544040.

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22

Sucheston, Lara E. "STATISTICAL METHODS FOR THE GENETIC ANALYSIS OF DEVELOPMENTAL DISORDERS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1175883318.

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23

Marschall, Tobias [Verfasser]. "Algorithms and statistical methods for exact motif discovery / Tobias Marschall." Dortmund : Universitätsbibliothek Technische Universität Dortmund, 2011. http://d-nb.info/1012572064/34.

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24

Georgieva, Antoniya. "Stochastic methods and genetic algorithms for neural network learning." Thesis, University of Portsmouth, 2008. https://researchportal.port.ac.uk/portal/en/theses/stochastic-methods-and-genetic-algorithms-for-neural-network-learning(67dae83c-ec3d-4db2-875c-6e7407a4144f).html.

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This thesis presents results from the developemnt, investigation, testing and evaluation of novel meta-heuristic techniques aiming to further improve the <i>state-of-the-art </i>of algorithms for local minima free Neural Network supervised learning. Several approaches for solving Global Optimisation problems that make use of novel meta-heuristic techniques, so called Low-discrepancy Sequences, and hybrid Evolutionary Algorithms are proposed here, investigated and critically discussed. Furthermore, the novel methods are tested on a number of multimodal mathematical function optimisation problem

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25

Cordell, Heather Jane. "Statistical methods in the genetic analysis of type 1 diabetes." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296834.

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26

Davies, Joanna L. "Statistical methods for modelling sources of heterogeneity in genetic epidemiology." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534165.

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27

Salem, Rany Mansour. "Statistical methods for genetic association analysis involving complex longitudinal data." Diss., [La Jolla] : [San Diego] : University of California, San Diego ; San Diego State University, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3366492.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.<br>Title from first page of PDF file (viewed Aug. 14, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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28

Mahjani, Behrang. "Methods from Statistical Computing for Genetic Analysis of Complex Traits." Doctoral thesis, Uppsala universitet, Avdelningen för beräkningsvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-284378.

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The goal of this thesis is to explore, improve and implement some advanced modern computational methods in statistics, focusing on applications in genetics. The thesis has three major directions. First, we study likelihoods for genetics analysis of experimental populations. Here, the maximum likelihood can be viewed as a computational global optimization problem. We introduce a faster optimization algorithm called PruneDIRECT, and explain how it can be parallelized for permutation testing using the Map-Reduce framework. We have implemented PruneDIRECT as an open source R package, and also Soft

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29

Xia, Fan, and 夏凡. "Some topics on statistical analysis of genetic imprinting data and microbiome compositional data." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206673.

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Genetic association study is a useful tool to identify the genetic component that is responsible for a disease. The phenomenon that a certain gene expresses in a parent-of-origin manner is referred to as genomic imprinting. When a gene is imprinted, the performance of the disease-association study will be affected. This thesis presents statistical testing methods developed specially for nuclear family data centering around the genetic association studies incorporating imprinting effects. For qualitative diseases with binary outcomes, a class of TDTI* type tests was proposed in a general two-st

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30

Sotero, Charity Faith Gallemit. "Statistical Support Algorithms for Clinical Decisions and Prevention of Genetic-related Heart Disease." Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10751893.

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<p> Drug-induced long QT syndrome (diLQTS) can lead to seemingly healthy patients experiencing cardiac arrest, specifically Torsades de Pointes (TdP), which may lead to death. Clinical decision support systems (CDSS) assist better prescribing of drugs, in part by issuing alerts that warn of the drug’s potential harm. LQTS may be either genetic or acquired. Thirteen distinct genetic mutations have already been identified for hereditary LQTS. Since hereditary and acquired LQTS both share similar clinical symptoms, it is reasonable to assume that they both have some sort of genetic componen

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31

Wang, Dennis Yi Qing. "Statistical modelling of gene regulation : applications to haematopoiesis." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607969.

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32

Dick, Grant, and n/a. "Spatially-structured niching methods for evolutionary algorithms." University of Otago. Department of Information Science, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080902.161336.

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Traditionally, an evolutionary algorithm (EA) operates on a single population with no restrictions on possible mating pairs. Interesting changes to the behaviour of EAs emerge when the structure of the population is altered so that mating between individuals is restricted. Variants of EAs that use such populations are grouped into the field of spatially-structured EAs (SSEAs). Previous research into the behaviour of SSEAs has primarily focused on the impact space has on the selection pressure in the system. Selection pressure is usually characterised by takeover times and the ratio between t

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33

Sofer, Tamar. "Statistical Methods for High Dimensional Data in Environmental Genomics." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10403.

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In this dissertation, we propose methodology to analyze high dimensional genomics data, in which the observations have large number of outcome variables, in addition to exposure variables. In the Chapter 1, we investigate methods for genetic pathway analysis, where we have a small number of exposure variables. We propose two Canonical Correlation Analysis based methods, that select outcomes either sequentially or by screening, and show that the performance of the proposed methods depend on the correlation between the genes in the pathway. We also propose and investigate criterion for fixing th

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34

Hu, Yueqing, and 胡躍清. "Some topics in the statistical analysis of forensic DNA and genetic family data." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38831491.

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35

Hutt, Benjamin David. "Evolving artificial neural network controllers for robots using species-based methods." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270831.

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36

Nicholson, George. "Statistical methods for inferring human population history from multi-locus genetic data." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275404.

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37

Lee, Michael James. "Methods in Percolation." Thesis, University of Canterbury. Physics and Astronomy, 2008. http://hdl.handle.net/10092/2365.

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Algorithms are presented for the computationally efficient manipulation of graphs. These are subsequently used as the basis of a Monte Carlo method for sampling from the microcanonical ensemble of lattice configurations of a percolation model within a neighbourhood of the critical point. This new method arbitrarily increments and decrements the number of occupied lattice sites, and is shown to be a generalisation of several earlier, purely incremental, methods. As demonstrations of capability, the method was used to construct a phase diagram for exciton transport on a disordered surface, and

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38

Arif, Omar. "Robust target localization and segmentation using statistical methods." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33882.

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This thesis aims to contribute to the area of visual tracking, which is the process of identifying an object of interest through a sequence of successive images. The thesis explores kernel-based statistical methods, which map the data to a higher dimensional space. A pre-image framework is provided to find the mapping from the embedding space to the input space for several manifold learning and dimensional learning algorithms. Two algorithms are developed for visual tracking that are robust to noise and occlusions. In the first algorithm, a kernel PCA-based eigenspace representation is used.

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39

Guan, Ting. "Novel Statistical Methods for Multiple-variant Genetic Association Studies with Related Individuals." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96243.

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Genetic association studies usually include related individuals. Meanwhile, high-throughput sequencing technologies produce data of multiple genetic variants. Due to linkage disequilibrium (LD) and familial relatedness, the genotype data from such studies often carries complex correlations. Moreover, missing values in genotype usually lead to loss of power in genetic association tests. Also, repeated measurements of phenotype and dynamic covariates from longitudinal studies bring in more opportunities but also challenges in the discovery of disease-related genetic factors. This dissertation fo

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40

Yu, Xuesong. "Statistical methods for analyzing genomic data with consideration of spatial structures /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9553.

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41

Swan, Roger William. "Optimisation of water treatment works using Monte-Carlo methods and genetic algorithms." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5868/.

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Hand movements reveal the temporal characteristics of visual attention Optimisation of potable water treatment could result in substantial cost savings for water companies and their customers. To address this issue, computational modelling of water treatment works using static and dynamic models was examined alongside the application of optimisation techniques including genetic algorithms and operational zone identification. These methods were explored with the assistance of case study data from an operational works. It was found that dynamic models were more accurate than static models at pre

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42

Winkleblack, Scott Kenneth swinkleb. "ReGen: Optimizing Genetic Selection Algorithms for Heterogeneous Computing." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1236.

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GenSel is a genetic selection analysis tool used to determine which genetic markers are informational for a given trait. Performing genetic selection related analyses is a time consuming and computationally expensive task. Due to an expected increase in the number of genotyped individuals, analysis times will increase dramatically. Therefore, optimization efforts must be made to keep analysis times reasonable. This thesis focuses on optimizing one of GenSel’s underlying algorithms for heterogeneous computing. The resulting algorithm exposes task-level parallelism and data-level parallelism pre

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43

Dambreville, Samuel. "Statistical and geometric methods for shape-driven segmentation and tracking." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22707.

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Thesis (Ph. D.)--Electrical and Computer Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Allen Tannenbaum; Committee Member: Anthony Yezzi; Committee Member: Marc Niethammer; Committee Member: Patricio Vela; Committee Member: Yucel Altunbasak.

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44

Howie, Bryan. "Statistical methods for phasing haplotypes and inputing genotypes in large population genetic datasets." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531825.

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Gale, Joanne. "Statistical Methods for the Analysis of Quantitative Trait Data in Genetic Association Studies." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504345.

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46

Lipson, Mark (Mark Israel). "New statistical genetic methods for elucidating the history and evolution of human populations." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/89873.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mathematics, 2014.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 165-173).<br>In the last few decades, the study of human history has been fundamentally changed by our ability to detect the signatures left within our genomes by adaptations, migrations, population size changes, and other processes. Rapid advances in DNA s

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Tachmazidou, Ioanna. "Bayesian statistical methods for genetic association studies with case-control and cohort design." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4398.

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Large-scale genetic association studies are carried out with the hope of discovering single nucleotide polymorphisms involved in the etiology of complex diseases. We propose a coalescent-based model for association mapping which potentially increases the power to detect disease-susceptibility variants in genetic association studies with case-control and cohort design. The approach uses Bayesian partition modelling to cluster haplotypes with similar disease risks by exploiting evolutionary information. We focus on candidate gene regions and we split the chromosomal region of interest into sub-r

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48

Iotchkova, Valentina Valentinova. "Bayesian methods for multivariate phenotype analysis in genome-wide association studies." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:66fd61e1-a6e3-4e91-959b-31a3ec88967c.

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Most genome-wide association studies search for genetic variants associated to a single trait of interest, despite the main interest usually being the understanding of a complex genotype-phenotype network. Furthermore, many studies collect data on multiple phenotypes, each measuring a different aspect of the biological system under consideration, therefore it can often make sense to jointly analyze the phenotypes. However this is rarely the case and there is a lack of well developed methods for multiple phenotype analysis. Here we propose novel approaches for genome-wide association analysis,

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49

Li, Li. "Evolutionary optimization methods for mass customizing platform products." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B3955790X.

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Lee, Yiu-fai, and 李耀暉. "Analysis for segmental sharing and linkage disequilibrium: a genomewide association study on myopia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43912217.

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