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Dissertations / Theses on the topic 'Genetic analyses'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Johansson, Henrik. "Microfluidic and Molecular Tools for Genetic Analyses." Doctoral thesis, Uppsala universitet, Medicinsk genetik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-121536.

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Methods that enable interrogation of multiple genomic regions in parallel are very useful for efficient detection of genetic variation. Two different types of probes are described in this thesis that can be used for direct analysis or for sample preparation upstream of Next Generation Sequencing. In addition to the development of molecular probing systems it also reports on the progress of two assay formats for biological experiments. The Selector probe enrich for genomic regions of interest by probe mediated specific circularization of target fragments. Amplification based enrichment of circ

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2

Ussar, Siegfried. "Genetic analyses of Kindlins in mice." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-100876.

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3

Hastings, Ian M. "Genetic and biochemical analyses of growth." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/10948.

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4

Neamat-Allah, Mustafa Ahmed. "The genetic analyses of diabetic nephropathy." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369913.

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5

Tsuchiya, Yoichi. "Application of genetic analyses to brewing." Kyoto University, 1999. http://hdl.handle.net/2433/181920.

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6

Ashbrook, David. "A systems-genetics analyses of complex phenotypes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/a-systemsgenetics-analyses-of-complex-phenotypes(a3e7ad8e-b23b-40fd-821e-26a6c1a63d38).html.

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Complex phenotypes are traits which are influenced by many factors, and not just a single gene, as for classical Mendelian traits. The brain, and its resultant behaviour, gives us a large subset of complex phenotypes to examine. Variation in these traits is affected by a range of different influences, both genetic and environmental, including social interactions and the effects of parents. Systems-genetics provides us with a framework in which to examine these complex traits, seeking to connect genetic variants to the phenotypes they cause, through intermediate phenotypes, such as gene express

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7

Cleary, Helen Julia. "Genetic analyses of radiation-induced leukaemias/lymphomas." Thesis, Brunel University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324649.

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8

Anderson, Carl. "Genetic analyses of age at onset traits." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/1793.

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The identification of factors underlying complex trait variation is a major goal in the field of genetics. For normally distributed, fully observed trait data there are many well established statistical methods for partitioning phenotypic variation and for mapping quantitative trait loci (QTL). Survival or time-to-event traits often follow non-normal distributions and frequently contain partially-known (or censored) trait data. If standard statistical methods are used to analyse age at onset data a bias can be introduced through a failure to account for the non-normal distribution of the data

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9

Nettelblad, Carl. "Using Markov models and a stochastic Lipschitz condition for genetic analyses." Licentiate thesis, Uppsala universitet, Avdelningen för teknisk databehandling, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120295.

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A proper understanding of biological processes requires an understanding of genetics and evolutionary mechanisms. The vast amounts of genetical information that can routinely be extracted with modern technology have so far not been accompanied by an equally extended understanding of the corresponding processes. The relationship between a single gene and the resulting properties, phenotype of an individual is rarely clear. This thesis addresses several computational challenges regarding identifying and assessing the effects of quantitative trait loci (QTL), genomic positions where variation is

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10

Pernhorst, Katharina [Verfasser]. "Molecular genetic analyses in acquired epilepsies / Katharina Pernhorst." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1047622750/34.

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11

Jiang, Guifeng. "Developing microfluidic devices for genetic and biochemical analyses." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60304.pdf.

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12

Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.

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13

Benyamin, Beben. "Genetic analyses of quantitative traits in human twins." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/10786.

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The aim of this thesis is to understand the genetic basis of the variation of human quantitative traits using data from twins and (to some extent) their families. Traits investigated include behavioural traits (intelligence), clinical traits (the metabolic syndrome) and anthropometric measures (height). The importance of human twins for understanding genetic variation in human quantitative traits is reviewed. The use of a novel finite mixture distribution model to partition phenotypic co(variance) of a trait into underlying genetic and environmental factors from twins of unknown zygosity is pr

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14

McManamy, Charles Stanley. "Medulloblastoma : biological insights from morphological and genetic analyses." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413387.

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15

Yang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.

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16

Acar, Hande. "Bioinformatic Analyses In Microsatellite-based Genetic Diversity Of Turkish Sheep Breeds." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612585/index.pdf.

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In the present study, within and among breed genetic diversity in thirteen Turkish sheep breeds (Sakiz, Karag&uuml<br>l, Hemsin, &Ccedil<br>ine &Ccedil<br>apari, Norduz, Herik, Akkaraman, Dagli&ccedil<br>, G&ouml<br>k&ccedil<br>eada, Ivesi, Karayaka, Kivircik and Morkaraman<br>in total represented by 628 individuals) were analyzed based on 20 microsatellite loci. Loci were amplified by Polymerase Chain Reactions and products were electronically recorded and converted into [628 x 20] matrix representing genotypes of individuals. Reliability of the genotyping and genetic diversity analyses were

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17

Gustafsson, Susanne. "Population genetic analyses in the orchid genus Gymnadenia : a conservation genetic perspective." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3305.

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18

Nutter, Lauryl M. J. "Genetic and molecular analyses of Pkc53E in Drosophila melanogaster." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24553.pdf.

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19

Lymperopoulos, Panagiotis. "Genetic and biochemical analyses of the Arabidopsis atToc90 protein." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/11073.

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Chloroplasts are photosynthetic organelles in plant and algal cells that capture sunlight energy to form energy-rich molecules that are the basis for almost all life. Chloroplast development requires more than 3000 different proteins, most of which are encoded by nuclear DNA. Thus, chloroplasts must import most of their proteins from the cytosol. They are surrounded by a double membrane called the envelope. Embedded in the envelope are the TOC and TIC complexes (translocon at the outer and inner envelope membrane of the chloroplast, respectively), which mediate protein import into the organell

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20

Colombo, Francesca. "Funtional analyses of genetic elements associated with lung cancer." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537004.

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21

Zishiri, Oliver Tendayi. "Genetic analyses of South African terminal sire sheep breeds." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4034.

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Thesis (MScAgric (Animal Sciences))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: Fluctuations and a general decline in the ratio between wool and meat prices resulted in marked changes in the South African sheep industry. Commercial producers now exploit other mechanisms such as terminal crossbreeding of Merino-type with meat type breeds or dual-purpose breeds to attain short-term benefits resulting from price fluctuations between wool and mutton without compromising the wool-producing capacities of ewe flocks. Most components of lamb production have low heritability. However, h

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22

Collins, Lewis Alexander. "Genetic analyses of circadian and seasonal phenotypes in Drosophila." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/28759.

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When an organism migrates from one area to another it comes into contact with many boundaries to its survival and fitness. The fruitfly Drosophila melanogaster has migrated from Africa, into Europe and colonised much of the rest of the world. The subject of this thesis is to better understand how Drosophila has adapted to survive the temperate climates in Europe. The variability of temperature and light from one season to the next makes adaptation of the circadian clock and life history strategy all the more important. Drosophila appear to have adjusted to the new conditions by exhibiting diap

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23

Bassitta, Sánchez Marta. "Genetic analyses of adaptive processes in the podarcis genus." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672464.

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[eng] Wall lizards from the Podarcis genus, which have diversified and evolved in the Mediterranean basin, present wide morphological, ecological, and genetic variability. This diversity plays a key role in the maintenance of the evolutionary and adaptative potential of all the Podarcis populations and, consequently, in their conservation management. The main point of this thesis was to investigate adaptive processes in the Podarcis genus, examining how evolutionary mechanisms have shaped genomic and phenotypic divergence in different Podarcis populations. Specifically, it focuses on the Poda

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24

Gokcek, Cigdem. "Mitochondrial Dna (mtdna) Sequence Analyses Of Kangal Dogs In Turkey." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606579/index.pdf.

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Kangal dogs are the most popular dogs of Turkey due to their strength, intelligence, loyalty, endurance to extreme temperatures and their lack of predatory behavior towards livestock. In this study to provide genetic information about the distinctness of Kangal and Akbash dogs and hence to provide a basis to conserve them separately, 585 base pair of the mitochondrial DNA (mtDNA) control region sequence was analysed in 105 Kangal and 9 Akbash dog samples. All the results indicated that Kangal and Akbash dogs were different from each other. Comparison of the Turkish data with those from other d

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25

Banér, Johan. "Genetic Analyses using Rolling Circle or PCR Amplified Padlock Probes." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3339.

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<p>Padlock probes are useful in a variety of genetic applications, some of which require that the probes are amplified in order to generate detectable signals. Two general padlock amplification methods, RCA and PCR, are discussed in this thesis.</p><p>The isothermal rolling circle amplification (RCA) mechanism is described in detail as well as how a target strand affects primer extension. A mechanism to resolve the topological constraint imposed by the target strand, to which a padlock probe has been linked, is also discussed. We also present a more powerful amplification technique, termed ser

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26

Zhang, Qiang. "Genetic and Expression Analyses of the 'Nkrp1-Clr' Gene Cluster." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23271.

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Natural killer (NK) cells, lymphocytes of the innate immune system, can recognize a wide array of cells via several receptors families such as Ly49 and NKR-P1. The Nkrp1 gene family encode for C-type lectin-like receptors which can recognize their ligands, Clr, on target cells. Nkrp1 and Clr genes are intertwined in the NK gene complex and are thus inherited together. The Nkrp1-Clr genes in 129S6 and BALB/c mouse strains show significant sequence polymorphism compared to those of C57BL/6 mice while the overall gene organization and gene number are conserved. RT-PCR was utilized to study the ex

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27

Leiß, Michael. "Genetic analyses of fibronectin functions in vivo and in vitro." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1414/.

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28

Taylor, Kristen Hawkins. "Genetic analyses of bovine CARD15, a putative disease resistance gene." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/219.

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Through a binding partner the CARD15 gene activates NF-kB, a molecule with a role in the initiation of the inflammatory immune response. The gene is highly conserved in both structure and function in human and mouse and has recently been implicated as a disease resistance gene in Crohn's disease and Blau Syndrome in human. The gene's relationship to disease and its conservation between species suggests that it may also have a conserved role in bovine disease resistance. To elucidate the potential role of bovine CARD15 in disease resistance, the gene was characterized in cattle. Bovine CARD

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29

Stenberg, Johan. "Software Tools for Design of Reagents for Multiplex Genetic Analyses." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6832.

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30

Banér, Johan. "Genetic analyses using rolling circle or PCR amplified padlock probes /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3339.

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31

Burch, April Dawn. "Genetic, biochemical, and structural analyses of the Microviridae scaffolding proteins." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/284307.

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Scaffolding proteins are transiently associated with morphogenetic intermediates but are not found in the mature viral particle. These proteins promote the efficiency and fidelity of particle formation by ensuring proper interactions between viral proteins, promoting the nucleation of assembly, and aiding in determining appropriate capsid size. The goal of the proposed research is to understand how scaffolding proteins recognize and interact with viral precursors thus enabling them to obtain an assembly active form and defining the requirements for, and constrains on, these interactions. Micro

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32

Oladapo, Mosekunola. "Genetic and metabonomic analyses of the molecular basis of hypertension." Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545984.

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33

Smith, Algina Maria Johanna. "Genetic analyses of growth traits for the Simbra composite breed." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4168.

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Thesis (MScAgric (Animal Sciences))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: The aim of this study was to evaluate the Simbra breed of cattle for certain non-genetic as well as genetic parameters influencing live weight traits in the breed. Live weight traits included birth weight (BW), weaning weight at 200 days of age (WW), yearling weight at 400 days of age (YW) and 600 day weight. The Simmental and Simbra Breeders’ Society of Southern Africa availed 148751 records for analysis from the year 1987 till 2009. Due to deficiencies of various kinds in the data and the restric

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34

Kaszás, Étienne. "Molecular and genetic analyses of the maize B chromosome centromere /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841157.

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35

Facette, Michelle R. "Biochemical and genetic analyses of pectins in arabidopsis seed mucilage /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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36

Brixey, Rachel J. E. "Genetic analyses of MAP kinase signalling in mouse gonad development." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:54242de2-8e43-4cf2-ad12-d94a2c187c44.

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Sexual development begins with the process by which the bipotential gonads of the embryonic urogenital ridge develop into either testes or ovaries. In the mouse, sex determination occurs at around 11.5 dpc and depends on the presence or absence of the Y chromosome and the associated activity of the testis-determining gene, Sry, in supporting cell precursors. The mutually antagonistic male and female developmental pathways are regulated by many cellular and molecular processes, disruption of which can lead to disorders of sex development (DSDs). However, many of the molecular mechanisms regulat

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37

Breadon, Robert Leslie. "Development of a system of genetic analyses for Rhodomicrobium vannielii." Thesis, University of Warwick, 1988. http://wrap.warwick.ac.uk/106493/.

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Preliminary experiments, to find phage or bacteriocin activity which might be plasmid-encoded amongst available strains of the Rhodopirillaceae were unsuccessful, and no phage were isolated from the natural environment. The technique for phototrophic plate growth of Rm. vannielii was found to be unsuitable for basic genetic experiments and a method using microaerophilic growth was developed. The latter was found to yield better results in both mutagenesis and conjugation experiments despite an increased incubation time relative to phototrophic growth (i.e. 14 instead of 3-5 days to obtain colo

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38

Burg, Theresa Marie. "Genetic analyses of albatrosses : mating systems, population structure and taxonomy." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621952.

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39

Patterson, James Simon. "Comparative morphometric and molecular genetic analyses of triatominae (Hemiptera: Reduviidae)." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2007. http://researchonline.lshtm.ac.uk/682370/.

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Triatomine bugs (Hemiptera: Reduviidae: Triatominae) are the vectors of Chagas disease in South and Central America. Chagas disease predominantly affects poor rural communities with simply constructed housing susceptible to infestation by triatomines. Chagas disease is restricted to the Americas largely due to the limited distribution of triatomine bugs. The global diversity of triatomines is -130 species, of which only -10% are known to occur outside the Americas, one species (Triatoma rubrofasciata) is tropicopolitan, and the others are concentrated on the Indian subcontinent (Linshcosteus s

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40

Meechan, Daniel William. "Complementary genetic and functional analyses of genes involved in adiposity." Thesis, Sheffield Hallam University, 2003. http://shura.shu.ac.uk/20051/.

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Leptin is a 16-kDa protein that is primarily secreted by adipose tissue. It affects body mass regulation by constituting part of the adipostat, that acts to alert the brain of the body's stored energy levels. Additional roles in immune function, reproduction and inflammation are known. Genetic studies of single nucleotide polymorphisms (SNPs), that exist in the extracellular domain of the leptin receptor gene, were undertaken in a population of European Caucasian postmenopausal women to investigate associations with indicators of adiposity. Homozygosity of the G allele of the LYS109ARG SNP was

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41

Legodi, Mankone Priscilla. "Genetic characterisation of colophospermum mopane (sensu lato) using RAPD analyses." Thesis, University of Limpopo (Turfloop Campus), 2007. http://hdl.handle.net/10386/826.

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Thesis (M.Sc. (Molecular and Life Sciences)) --University of Limpopo, 2007<br>Colophospermum mopane (sensu lato) is currently recognised on morphological and physiological characteristics. To add to the suite of taxonomic characters, the genetic variability of C. mopane (sensu lato) was investigated using the RAPD technique. DNA was extracted from young seedlings and mature leaves using the CTAB method. Initially, the DNA extraction was problematic due to the presence of polysaccharides, making PCR nearly impossible. An additional phenol precipitation step was introduced to purify the DNA used

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42

Maddinapudi, Sri L. P. "Genetic analyses of pre-meiotic DNA replication in Saccharomyces cerevisiae." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/29072/.

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Precise and complete replication of the genome is essential for a cell. Chromosome replication follows a defined temporal order, depending on the efficiency and timing of the replication origins. However, the mechanism regulating origin activity has not been properly explained to date. Yeast replication origins are very well characterized and well studied. Genome wide replication in yeast was detailed through deep sequencing in various studies. In yeast, there are multiple replication origins for the complete replication of the genome. In Saccharomyces cerevisiae, there are ~400 replication or

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43

He, Wei. "Biochemical and genetic analyses of Jatropha curcas L. seed composition." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/1941/.

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Diminishing worldwide fossil fuel reserves coupled with the negative impact of their use on the environment has led to increased research and development of renewable energy sources. Renewable liquid biofuels are in demand for the transport sector, particularly if they can be used directly in existing internal combustion engines. Jatropha curcas L. is a perennial plant which belongs to the Euphorbiaceae family. J. curcas seeds contain about 30% oil which is suitable for biodiesel production, and therefore it has received global interest as a source of biofuel. However, to date J. curcas has no

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44

Brooks, S. P. "Molecular genetic and functional analyses of X-linked congenital cataract." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444386/.

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Nance-Horan Syndrome (NHS) is an X-linked developmental syndrome characterised by congenital cataract, dental anomalies, and dysmorphological features often associated with mental retardation. The NHS locus on Xp22.13 is encompassed by the disease locus for X- linked congenital cataract (CXN). Analysis of microsatellites within the CXN family resulted in refinement of the CXN disease interval, reducing the region of overlap between the CXN and NHS disease loci. Candidate genes in the overlapping intervals were identified bioinformatically and their genomic structures evaluated. Patient DNA was

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45

Wong, Hoi-man Emily, and 黃凱敏. "Genome-wide association analyses on complex diseases: from single-nucleotide polymorphism to copy numbervariation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50534099.

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Complex diseases, unlike Mendialian diseases, are often characterized by genetic heterogeneity and multifactorial inheritance, involving defects in genes from the same or multiple alternative pathways. Many congenital diseases and psychiatric disorders are complex diseases, and incur heavy health care burden on the society. With the advancement in high-throughput genotyping technologies and the availability of the human single nucleotide polymorphism (SNP) catalogue, genome-wide association study (GWAS) has been widely used to investigate the genetic component of complex diseases. Copy number

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46

Vellani, Nina N. "Analyses of immediate early and early transcripts and major early region, E10, of murine cytomegalovirus." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/32374.

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Murine cytomegalovirus (MCMV) is used as a biological model for human cytomegalovirus (HCMV). Latency, persistence and reactivation are same of the important aspects of the murine model that share analogies with human CMV infections. In order to elucidate the molecular mechanisms leading to these events, in-depth analyses of the murine model are required at the transcriptional level. During the MCMV replication cycle, there is a sequential expression of different regions of the viral genome, hence the transcripts are divided into three kinetic classes; the immediate early (IE), early (E) and l

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47

Macdonald, Stuart J. "Evolutionary and genomic analyses of complex traits in Drosophila." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365832.

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48

Karabicak, Seher. "Application Of Surface-enhanced Raman Scattering (sers) Method For Genetic Analyses." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613130/index.pdf.

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Raman spectroscopy offers much better spectral selectivity but its usage has been limited by its poor sensitivity. The discovery of surface-enhanced Raman scattering (SERS) effect, which results in increased sensitivities of up to 108-fold for some compounds, has eliminated this drawback. A new SERS active substrate was developed in this study. Silver nanoparticle-doped polyvinyl alcohol (PVA) coated SERS substrate prepared through chemical and electrochemical reduction of silver particles dispersed in the polymer matrix. Performances of the substrates were evaluated with some biologically i

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49

Pleiser, Sandra [Verfasser], and Eugen [Akademischer Betreuer] Kerkhoff. "Mouse genetic analyses of Spir functions / Sandra Pleiser. Betreuer: Eugen Kerkhoff." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1027949223/34.

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50

Xu, Jianping. "Mating and population genetic analyses of the basidiomycete fungus, Agaricus bisporus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0021/NQ28090.pdf.

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