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Dissertations / Theses on the topic 'Genetic approaches'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Dubé, Marie-Pierre. "New approaches in human genetic analysis." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36581.

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The present thesis covers two aspects of statistical analysis applied to the genetics of human diseases. First, the significance of LOD-score results for the confirmation of linkage is addressed, with special emphasis on small pedigrees. A new analytical approach is presented for the linkage analysis of heterogenetic traits, using hereditary spastic paraplegia as a model, a disease well suited for the analyses. The critical significance values for confirmation of linkage are evaluated using Bayesian statistics, and empirical P-values for LOD score results are calculated using computer simulati
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2

Qiao, Dandi. "Statistical Approaches for Next-Generation Sequencing Data." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10689.

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During the last two decades, genotyping technology has advanced rapidly, which enabled the tremendous success of genome-wide association studies (GWAS) in the search of disease susceptibility loci (DSLs). However, only a small fraction of the overall predicted heritability can be explained by the DSLs discovered. One possible explanation for this ”missing heritability” phenomenon is that many causal variants are rare. The recent development of high-throughput next-generation sequencing (NGS) technology provides the instrument to look closely at these rare variants with precision and efficiency
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3

Abrahamsen, Bjarke. "Genetic approaches to somatosensation." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444087/.

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Three approaches to understanding peripheral pain pathways are described in this thesis. Cre-loxP technology has been used to delete genes specifically in specialised sensory neurons that respond to tissue damage (nociceptors). The sodium channel selective Nav1.8 promoter is used to drive Cre expression. I used a mouse expressing diphtheria toxin A-chain downstream of a floxed stop signal, crossed with the Nayl.8Cre mouse to delete all cells expressing this channel. This lead to massive cell loss of nociceptive neurons, associated with altered pain behaviour. The mice lost cold, mechanical and
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4

Solinas, Antonio. "Novel approaches in genetic analysis." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274529.

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5

Dubé, Marie-Pierre. "New approaches in human genetic analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0030/NQ64551.pdf.

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6

Shah, Paresh Rameshchandra. "Complex genetic approaches to neurodegenerative diseases." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445084/.

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Neurodegenerative diseases are fatal disorders in which disease pathogenesis results in the progressive degeneration of the central and/or the peripheral nervous systems. These diseases currently affect -2% of the population but are expected to increase in prevalence as average life expectancy increases. The majority of these diseases have a complex genetic basis. The work presented in this thesis aimed to investigate the genetic basis of two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and the human prion diseases kuru and sporadic Creutzfeldt-Jakob disease (sCJD), using no
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7

Souleman, Dima. "Genetic consequences of colonization of a metal-polluted environment, population genetics and quantitative genetics approaches." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10006/document.

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Les habitats naturels sont de plus en plus détruits et fragmentés par l'expansion urbaine et les activités humaines. La fragmentation des espaces naturels et agricoles par les bâtiments et les nouvelles infrastructures affecte la taille, la connectivité et la qualité des habitats. Les populations d’organismes vivants sur ces territoires anthropisés sont alors plus isolées. Or, la différenciation entre populations d’un même organisme dépend de processus démographiques et génétiques tels que la dérive génétique, le flux génétique, la mutation et la sélection naturelle. La persistance et le dével
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8

Carnero-Montoro, Elena 1985. "Genomic and functional approaches to genetic adaptation." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/291115.

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The genetic basis of phenotypes that have contributed to the adaptation of species and organisms to new environments is a central question in evolutionary genetics. The recent accumulation of genetic variability data has allowed a genome-wide search for different signatures of positive selection which has led to the discovery of hundreds of putative candidate genes that may have played a role in adaptation. However, such hypothesis-free approaches do not reveal either causal variants or the actual biological mechanisms that have made each adaptation possible. Furthermore, the detection o
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9

Olumuyiwa, Ibikunle Ashiru. "Evolutionary approaches to mobile robot systems." Thesis, De Montfort University, 1997. http://hdl.handle.net/2086/10667.

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10

McCaskie, Pamela Ann. "Multiple-imputation approaches to haplotypic analysis of population-based data with applications to cardiovascular disease." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0160.

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[Truncated abstract] This thesis investigates novel methods for the genetic association analysis of haplotype data in samples of unrelated individuals, and applies these methods to the analysis of coronary heart disease and related phenotypes. Determining the inheritance pattern of genetic variants in studies of unrelated individuals can be problematic because family members of the studied individuals are often not available. For the analysis of individual genetic loci, no problem arises because the unit of interest is the observed genotype. When the unit of interest is the linear combination
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11

Kent, Simon. "Evolutionary Approaches to Robot Path Planning." Thesis, Brunel University, 1999. http://bura.brunel.ac.uk/handle/2438/1276.

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The ultimate goal in robotics is to create machines which are more independent and rely less on humans to guide them in their operation. There are many sub-systems which may be present in such a robot, one of which is path planning — the ability to determine a sequence of positions or configurations between an initial and goal position within a particular obstacle cluttered workspace. Many classical path planning techniques have been developed, but these tend to have drawbacks such as their computational requirements; the suitability of the plans they produce for a particular application; or ho
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12

Blechacz, Boris Roman Alexander. "Genetic approaches to the therapy of hepatocellular carcinoma." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505358.

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Hepatocellular carcinoma (HCC) is a devastating malignancy originating from hepatocytes. There is an urgent need for novel therapeutic approaches. Currently explored gene therapy systems have not yet achieved significant survival benefits. The aim of this thesis was the development and evaluation of novel genetic approaches to this malignancy.
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13

Ahmadian, Afshin. "Approaches for analysis of mutations and genetic variations." Doctoral thesis, Stockholm : Tekniska högsk, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3113.

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14

Fernebro, Jenny. "Genetic approaches towards understanding pneumococcal virulence and biology /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-403-7/.

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15

Andersen, Malin. "Computational and experimental approaches to regulatory genetic variation." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4593.

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16

Wang, Xinchen Ph D. Massachusetts Institute of Technology. "Deciphering genetic associations using genome-wide epigenomics approaches." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111239.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2017.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Genetic mapping of the drivers of complex human phenotypes and disease through the genome-wide association study (GWAS) has identified thousands of causal genetic loci in the human population. However, genetic mapping approaches can often only reveal a particular
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17

Scoccianti, Chiara. "Biomarkers of environmental exposure : genetic and epigenetic approaches." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9485.

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Exposure assessment in cancer epidemiological studies relies on measurable intermediate molecular biomarkers with high sensitivity and specificity in order to prevent common problems due to misclassification of exposure. Studies on the early stages of carcinogenesis have helped to identify molecular changes that are detectable in pre-cancerous lesions and that are thought to occur as the result of specific exposures such as tobacco smoking. More recently, in vitro evidence started to support the potential cancer-protective role of various micronutrients acting through epigenetic and genetic me
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18

Bydon, Mohamad. "Molecular genetic approaches to diseases of neural development." [New Haven, Conn. : s.n.], 2008. http://ymtdl.med.yale.edu/theses/available/etd-11212008-112418/.

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19

Gaynor, Sophia Catherine. "Genetic and functional approaches to understanding suicidal behavior." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6108.

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Suicidal behavior, a complex phenotype encompassing attempted and completed suicide, has been shown through epidemiological studies to have a heritable component. Two major factors contribute to this heritability. The first is a preexisting psychiatric disorder, such as bipolar disorder or major depression. These disorders are heritable themselves, and individuals with these disorders are at a higher risk of suicide than the general population. The second contributing factor is thought to be indepen
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20

D'AVERSA, Elisabetta. "Innovative approaches for molecular diagnosis of genetic diseases." Doctoral thesis, Università degli studi di Ferrara, 2019. http://hdl.handle.net/11392/2488091.

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The diagnosis of genetic diseases in fetal age is obtained using invasive procedures, but these hide a high risk of miscarriage. Recently, non-invasive pre-natal diagnosis, based on circulating cell-free fetal DNA (ccffDNA) analysis starting from a simple maternal peripheral blood sampling, has become increasingly important. The fetal sex determination is necessary for predicting the risk of X-linked disorders. Against this background, the principal purpose of the first part of the research was the development of rapid and sensitive non-invasive diagnostic methods for the fetal sex determinati
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21

Gamba, A. "APPROACHES TO THE MOLECULAR BASIS OF GENETIC DISEASES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/545159.

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Throughout my PhD period, I experimented different approaches to a complex problem, that is, assessing molecular basis of genetic diseases. In the present thesis I will show how both experimental and computational techniques can contribute to the study of typical biochemistry topics, providing non-conventional points of view and advanced technical and technological supports. The first part of my PhD was focused on physico-chemical investigation, while the second part was devoted to big-data and network analysis. For this reason my thesis is divided into two chapters. The former describes a t
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22

Hudson, Julie. "Maternal Gene-Environment Effects: An Evaluation of Statistical Approaches to Detect Effects and an Investigation of the Effect of Violations of Model Assumptions." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39637.

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Discovering the associations between genetic variables and disease status can help reduce the burden of disease on society. This thesis focuses on the methods required to detect maternal genetic effects (an effect where the genes of the mother affect the disease risk of the child) and interaction effects between these maternal genes and environmental variables in trio data consisting of parents and an affected child. A simulation study was conducted to determine the extent to which testing for these effects is affected by violations to the mating symmetry assumption required for two current me
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23

Zhang, Ching. "Genetic algorithm approaches for efficient multiple molecular sequence alignment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0013/NQ30660.pdf.

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24

Mitchell, Helen Susan. "Women and breast cancer: feminist approaches to genetic information." Thesis, Keele University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491671.

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Genetically predisposed breast cancer, commonly Breast Cancer 1 (BRCA1) . ·or Breast Cancer 2 (BRCA2), accounts for 5-10cro of the 41,000 women . diagnosed with breast cancer in the United Kingdom each year (Breast ~Cancer Care, 2006). The isolation of such genes has resulted in a - .-'perceived mora/responsibility for patients to access, disclose and disseminate information to family members who may be affected (Buller, 2000). This information can be difficult to interpret and poses complex questions of privacy, confi~entiality and discrimination for health care professionals when advising
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25

Pongsri, C. "Genetic approaches to improvement of tilapia culture in Thailand." Thesis, Swansea University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638545.

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Masculinization and feminization of the Jitralada strain of <i>Oreochromis niloticus</i> (L.) could be induced with a high level of success by oral administration of a 40-mg kg<SUP>-1</SUP> of 17-α-methyltestosterone and 40-mg mg^-1 of ethynyl-estradiol, respectively, to the first-feeding fry for a period of 21 days. On the other hand, optimization of dosage and means of application of 17-β-oestradiol or <i>Pueraria mirifica</i> roots are still needed in inducing reliable feminization of this strain. Differences in the results obtained are discussed and it is concluded that there are significa
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26

Hart, Jaynee E. "Biochemical and genetic approaches to modulate phototropin photoreceptor sensitivity." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30991/.

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The necessity of light for plants to sustain their autotrophic lifestyle has made the optimization of growth to maximize light capture a crucial strategy for survival in light-limiting environments. Increases in light capture can be achieved through alterations in plant architecture, such as modifications to leaf position and stem length. Responses to the light environment are mediated by a network of photoreceptor proteins, which sense specific wavelengths of light and respond to light excitation by initiating signaling. Higher plants respond to red and far-red light through the phytochrome f
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27

Adiredjo, Afifuddin Latif. "Water use efficiency in sunflower : Ecophysiological and genetic approaches." Phd thesis, Toulouse, INPT, 2014. http://oatao.univ-toulouse.fr/20177/1/adiredjo.pdf.

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Water use efficiency (WUE), measured as the ratio of plant biomass to water consumption, is an essential agronomical trait for enhancing crop production under drought. Measuring water consumption is logistically difficult, especially in field conditions. The general objective of the present Thesis is to respond to three main questions: (i) can WUE be determined by using carbon isotope discrimination (CID), easy to measure?, (ii) how WUE and CID variation analysis can contribute to the genotypic selection of sunflower subjected to drought?, and (iii) can WUE variation be revealed by the variati
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28

Jacobowitz, Joseph(Joseph R. ). "Reverse genetic approaches reveal gene redundancy in Arabidopsis anthers." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129041.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2020<br>Cataloged from student-submitted PDF of thesis.<br>Includes bibliographical references.<br>When aquatic plants migrated to land 500 million years ago, they were met with harsh conditions associated with terrestrial life, such as dry air, high radiance light, and high effective gravity. Early plants of this time period underwent rapid evolution to develop novel plant traits to mitigate these challenges - these traits remain highly conserved in modern land plants. Among the most important of these traits is the
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29

Bellan, Alessandra. "Genetic engineering approaches to increase microalgae light use efficiency." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427159.

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In the next fifty years world population will reach 9-10 billion of people. This increment will drastically increase energy and food demand. The current global food and energy supply chain is not sustainable and it causes increasing CO2 emissions, exacerbating the greenhouse effect and the climate change, whose effects we are already experiencing. The Climate Change conference hold in Paris in 2015 showed a global consensus on the need to drastically reduce carbon emissions to avoid the environmental disaster, which is leading to many negative effects like desertification, animal and plants sp
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30

ELSAYED, A. SAYED HUSSIEN. "FORWARD AND REVERSE GENETIC APPROACHES FOR CHARACTERISATION OF TILLERING GENES IN CEREALS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/230017.

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Recessive mutations in Cul4 locus was described as causing low tillering phenotype in barley. The locus was previously mapped to 0.22 cM genetic interval and Candidate Gene (CG) was proposed. In this study, we mapped the locus into 0.09 cM interval and proved the correspondence between the CG and cul4 phenotype by showing the recombination between CG and adjacent annotated genes. Also, we isolated three independent mutant alleles for Cul4 in the available mutant stocks, and we showed their correlation to cul4 phenotype. Detailed phenotyping of cul4 mutant lines revealed various effects on plan
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31

Godley, Paul Michael. "Directed intervention crossover approaches in genetic algorithms with application to optimal control problems." Thesis, University of Stirling, 2009. http://hdl.handle.net/1893/1143.

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Genetic Algorithms (GAs) are a search heuristic modeled on the processes of evolution. They have been used to solve optimisation problems in a wide variety of fields. When applied to the optimisation of intervention schedules for optimal control problems, such as cancer chemotherapy treatment scheduling, GAs have been shown to require more fitness function evaluations than other search heuristics to find fit solutions. This thesis presents extensions to the GA crossover process, termed directed intervention crossover techniques, that greatly reduce the number of fitness function evaluations re
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32

Na, Jong Kuk. "Genetic approaches to improve drought tolerance of tomato and tobacco." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127245631.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 104 p.; also includes graphics (some col.). Includes bibliographical references (p. 93-104). Available online via OhioLINK's ETD Center
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33

Glinka, Sascha. "Population Genetic Approaches to Detect Natural Selection in Drosophila melanogaster." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-37102.

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34

Nielsen, Janne T. "Molecular Genetic Approaches to Species Identification and Delineation in Elasmobranchs." NSUWorks, 2004. http://nsuworks.nova.edu/occ_stuetd/278.

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CHAPTER 2 The burgeoning shark-fishing industry has caused severe declines in many shark populations, prompting an urgent need for conservation and management of sharks on a species-specific basis. Many fisheries are managed on the basis of species groups due to difficulty in identifying the morphologically similar requiem sharks (Carcharhinidae) and their body parts. One diagnostic trait readily discernible in landed shark carcasses is the presence or absence of an interdorsal ridge, which allows shark carcasses to be categorized as either ridgeback or non-ridgeback sharks and narrows the ide
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35

Thuma, Leila Jasmin Marie. "Genetic approaches to study wound healing in flies and man." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715838.

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36

Jansson, Gunnar. "Approaches to genetic testing and evaluation in forest tree breeding /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5340-2.gif.

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37

Deming, Damon Joshua Baric Ralph S. "Genetic approaches to the study of coronavirus replication and pathogenesis." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,965.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.
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38

Drake, Pascal M. W. "Approaches to the genetic transformation of Sitka spruce (Picea sitchensis)." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320788.

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39

Wilkinson, Joy Elizabeth. "Approaches towards increasing disease resistance in plants using genetic engineering." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35368.

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40

Trochet, Holly. "Simple Bayesian approaches to modelling pleiotropy in genetic association data." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:a1e3d606-ef39-4ef7-981e-088d6703c04f.

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Genome-wide association studies (GWAS) have become one of the most common types of genetic studies, due to their success at finding markers associated with diseases and other traits of interest. With thousands of these studies performed in the last decade, a variety of methods have been developed to meta-analyze their results to search for variants that affect multiple traits. This thesis introduces one such method, based on approximate Bayes factors (ABFs), which relies only on effect size estimates and standard errors from GWAS. Through application to simulated data as well as three differen
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41

Arif, Uz Zaman Muhammad. "Genetic Dissection and Molecular Approaches of Root Morphology of Canola." Thesis, North Dakota State University, 2014. https://hdl.handle.net/10365/27276.

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The inheritance of root vigor and days to flowering were studied in the F2 populations derived from winter- and spring-type crosses and their reciprocal crosses. Root vigor was found to be controlled by three genes whereas, a single dominant gene was found to be responsible for days to flowering. Positive and significant correlation was found between seed yield and yield attributing traits, seed yield and root length, days to flowering and root length. Days to flowering was negatively correlated to seed yield. Linkage map was constructed with 262 SNP and 3 SSR markers. Two QTL for both root vi
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42

Raza, Abbas. "Genetic And Functional Approaches To Understanding Autoimmune And Inflammatory Pathologies." ScholarWorks @ UVM, 2020. https://scholarworks.uvm.edu/graddis/1175.

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Our understanding of genetic predisposition to inflammatory and autoimmune diseases has been enhanced by large scale quantitative trait loci (QTL) linkage mapping and genome-wide association studies (GWAS). However, the resolution and interpretation of QTL linkage mapping or GWAS findings are limited. In this work, we complement genetic predictions for several human diseases including multiple sclerosis (MS) and systemic capillary leakage syndrome (SCLS) with genetic and functional data in model organisms to associate genes with phenotypes and diseases. Focusing on MS, an autoimmune inflammato
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Fassone, E. "BIOCHEMICAL AND GENETIC APPROACHES TO UNRAVEL MITOCHONDRIAL COMPLEX I DEFICIENCY." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169915.

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Using biochemical and genetic approaches we have been able to identify the genetic defect underlying mitochondrial complex I deficiency in 3 patients out of the 12 patients in the cohort. The patient cohort investigated in this study is genetically heterogeneous, originating from several different geographical areas: England, France, the Middle East, Israel, India and Pakistan. They presented with different clinical phenotypes: Leigh syndrome, congenital lactic acidosis, hypertrophic cardiomyopathy, encephalopathy, developmental delay, Alpers’ disease. After having excluded the mitochondrial
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44

Lin, Ling. "Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/610.

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The development of methods and techniques is the driving force of scientific research. In this work, we described two large-scale screens in studying transcriptional activation and tumor suppression. In Part I, we studied transcriptional activation mechanisms by deriving and characterizing activation defective mutants. Promoter-specific transcriptional activators stimulate transcription through direct interactions with one or more components of the transcription machinery, termed the “target.” The identification of direct in vivo targets of activators has been a major challenge. We perform a
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45

Billakurthi, Kumari [Verfasser], and Peter [Gutachter] Westhoff. "Identification of C4 genetic determinants by comparative transcriptomics and forward genetic approaches / Kumari Billakurthi ; Gutachter: Peter Westhoff." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1175202460/34.

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46

Al, Turki Saeed. "Integrated approaches to elucidate the genetic architecture of congenital heart defects." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/245178.

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Congenital heart defects (CHD) are structural anomalies affecting the heart, are found in 1% of the population and arise during early stages of embryo development. Without surgical and medical interventions, most of the severe CHD cases would not survive after the first year of life. The improved health care for CHD patients has increased CHD prevalence significantly, and it has been estimated that the population of adults with CHD is growing ~5% per year. Understanding the causes of CHD would greatly help improve our knowledge of the pathophysiology, family counseling and planning and possibl
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47

Prior, Kent A. "Conservation biology of black rat snakes ecological, demographic, and genetic approaches /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/NQ26863.pdf.

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48

Murray, Seonaid Margaret. "Early detection of pancreatic cancer : use of genetic and proteomic approaches." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569146.

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Aims of the investigation The aims of this investigation were to detect pancreatic cancer earlier using both genetic and proteomic approaches. The aims of the genetic approach were to use Amplification Refractory Mutation System (ARMS) to detect KRAS mutations in blood serum and plasma, pancreatic juice and tissue from patients with pancreatic cancer, chronic pancreatitis and other benign disease controls. The aims of the proteomic approach were to use Isobaric Tags for Relative and Absolute Quantification (iTRAQ) to identify and quantify the proteins present in blood serum from patients with
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49

Morlon, Elodie. "Novel yeast genetic approaches to isolating Arabidopsis polyamine transport-related genes." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393126.

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50

Willetts, Sylvia. "Genetic and genomic approaches to understanding metal toxicity in Saccharomyces cerevisiae." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408649.

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