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Journal articles on the topic 'Genetic diseases of dogs'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Sampson, J. "Genetic disorders in dogs." Proceedings of the British Society of Animal Science 2003 (2003): 216. http://dx.doi.org/10.1017/s1752756200013740.

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There has been a shift over the last few years in the profile of diseases that veterinarians encounter in the dog. Improvements and developments in antibiotics, antihelminthics and more effective vaccines have controlled many of the infectious diseases that have caused problems in the past. As a result, there has been a relative increase in diseases that have a genetic basis.

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Shaffer, Lisa G., Christina J. Ramirez, Patricia Phelps, et al. "An International Genetic Survey of Breed-Specific Diseases in Working Dogs from the United States, Israel, and Poland." Cytogenetic and Genome Research 153, no. 4 (2017): 198–204. http://dx.doi.org/10.1159/000486774.

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Genetic diseases occur in breeds used for law enforcement. As important team members, dogs are expected to operate at peak performance for several years and are significant investments for both the initial purchase and extensive, specialized training. Previous studies have not focused on causes for retirement or euthanasia as genetic (inherited) versus acquired (environmental). We performed direct mutational analysis for breed-specific conditions on samples from 304 dogs including 267 law enforcement (122 US, 87 Israeli, and 58 Polish) and 37 search and rescue dogs. Genetic testing identified

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Reimann-Berg, N., J. Bullerdiek, H. Escobar, and I. Nolte. "Chromosome analyses in dogs." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 40, no. 03 (2012): 191–96. http://dx.doi.org/10.1055/s-0038-1623638.

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SummaryCytogenetics is the study of normal and abnormal chromosomes. Every species is characterized by a given number of chromosomes that can be recognized by their specific shape. The chromosomes are arranged according to standard classification schemes for the respective species. While pre-and postnatal chromosome analyses investigate the constitutional karyotype, tumor cytogenetics is focused on the detection of clonal acquired, tumor-associated chromosome aberrations. Cytogenetic investigations in dogs are of great value especially for breeders dealing with fertility problems within their

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Shearman, Jeremy R., and Alan N. Wilton. "Origins of the Domestic Dog and the Rich Potential for Gene Mapping." Genetics Research International 2011 (January 17, 2011): 1–6. http://dx.doi.org/10.4061/2011/579308.

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The unique breeding structure of the domestic dog makes canine genetics a useful tool to further the understanding of inherited diseases and gene function. Answers to the questions of when and where the dog was domesticated from the wolf are uncertain, but how the modern diversity of dog breeds was developed is documented. Breed development has resulted in many genetically isolated populations which are segregating for different alleles for disease and morphological and behavioral traits. Many genetic tools are available for dog research allowing investigation into the genetic basis of these p

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LaFond, Elizabeth, Gert J. Breur, and Connie C. Austin. "Breed Susceptibility for Developmental Orthopedic Diseases in Dogs." Journal of the American Animal Hospital Association 38, no. 5 (2002): 467–77. http://dx.doi.org/10.5326/0380467.

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A large-scale epidemiological study was conducted to determine breeds at risk for 12 developmental orthopedic diseases (DODs). Developmental orthopedic diseases investigated included canine hip dysplasia (CHD); craniomandibular osteopathy (CMO); fragmented coronoid process; hypertrophic osteodystrophy; Legg-Calvé-Perthes disease; osteochondrosis of the medial humeral condyle, caudal humeral head, femoral condyles, and talar trochlear ridges; panosteitis; patella luxation; and ununited anconeal process. Dogs that were diagnosed with any one of the diseases of interest at any of 10 veterinary t

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Łój, Magdalena, Magdalena Garncarz, and Michał Jank. "Genomic and genetic aspects of heart failure in dogs — A review." Acta Veterinaria Hungarica 60, no. 1 (2012): 17–26. http://dx.doi.org/10.1556/avet.2012.002.

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The most common causes of heart failure in dogs are valvular disease, predominantly endocardiosis, and myocardial disease, predominantly dilated cardiomyopathy. They are related to changes in the expression of several genes in the heart muscle and in peripheral blood nuclear cells which could be considered as prognostic or diagnostic markers of heart disease in dogs. Since many human genetic markers of heart failure have turned out to be useless in dogs, the screening for genomic markers of canine heart failure could give more insight into the molecular pathology of these diseases and aid the

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7

da Costa, Fernanda V. A., Marconi R. Farias, Daniele Bier, et al. "Genetic variability inMicrosporum canisisolated from cats, dogs and humans in Brazil." Mycoses 56, no. 5 (2013): 582–88. http://dx.doi.org/10.1111/myc.12078.

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RJEIBI, MOHAMED R., SAFA AMAIRIA, MARIEM ROUATBI, FATMA BEN SALEM, MOEZ MABROUK, and MOHAMED GHARBI. "Molecular prevalence and genetic characterization of piroplasms in dogs from Tunisia." Parasitology 143, no. 12 (2016): 1622–28. http://dx.doi.org/10.1017/s003118201600113x.

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SUMMARYIn this study, the prevalence of piroplasms in dogs was assessed using polymerase chain reaction (PCR) to identifyBabesiaandTheileriaspecies in 200 dogs from Northern and Central Tunisia between spring and autumn 2014. The overall molecular prevalence for piroplasms was 14·5% ± 0·05 (29/200); PCR detected 2 species, namelyBabesia vogeliandTheileria annulatawith an overall prevalence of 12·5 ± 0·04 and 2% ± 0·02, respectively. No differences in the molecular prevalences ofB. vogeliwere revealed for age and sex (P> 0·05). The molecular prevalence ofB. vogeliwas significantly higher in

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Boissevain, I. "Can the law help us to tackle genetic diseases that affect the welfare of dogs?" Animal Welfare 21, no. 1 (2012): 151–54. http://dx.doi.org/10.7120/096272812x13345905674169.

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10

Battilani, Mara, Sara Ciulli, Ernesto Tisato, and Santino Prosperi. "Genetic analysis of canine parvovirus isolates (CPV-2) from dogs in Italy." Virus Research 83, no. 1-2 (2002): 149–57. http://dx.doi.org/10.1016/s0168-1702(01)00431-2.

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Aizawa, T., R. Kano, Y. Nakamura, S. Watanabe, and A. Hasegawa. "The genetic diversity of clinical isolates of Malassezia pachydermatis from dogs and cats." Medical Mycology 39, no. 4 (2001): 329–34. http://dx.doi.org/10.1080/714031036.

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Paim Arruda Trevisan, Yolanda, Arleana Do Bom Parto Ferreira de Almeida, Luciano Nakazato, et al. "Frequency of Giardia duodenalis infection and its genetic variability in dogs in Cuiabá, Midwest Brazil." Journal of Infection in Developing Countries 14, no. 12 (2020): 1431–36. http://dx.doi.org/10.3855/jidc.13095.

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Introduction: Giardia duodenalis, a unicellular, eukaryotic, and flagellated protozoan, presents two evolutionary forms in its life cycle, namely, trophozoites and cysts. It causes diarrhea in humans, dogs, cats, rodents, and ungulates. Despite being morphologically similar, the isolates of G. duodenalis are genetically diverse, affecting the stability and unanimity of taxonomic classification. Since different Giardia assemblages may occur within one isolate, multilocus genotyping is recommended for the genetic identification. Methodology: To determine the frequency of G. duodenalis infe

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SHAO, X. Q., X. J. YAN, G. L. LUO, et al. "Genetic evidence for domestic raccoon dog rabies caused by Arctic-like rabies virus in Inner Mongolia, China." Epidemiology and Infection 139, no. 4 (2010): 629–35. http://dx.doi.org/10.1017/s0950268810001263.

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SUMMARYAn outbreak of rabies affected domestic raccoon dogs on an animal farm in Inner Mongolia, China in 2007. A study was conducted to characterize the aetiological agent and clarify the origin of the rabies virus. Brain tissues were obtained from five rabid raccoon dogs. Viral nucleoprotein antigen was detected in the brain tissues and five rabies viruses were isolated from these rabid animals. Phylogenetic analysis of the N and G gene sequences showed that these isolates were closely related to Arctic-like rabies viruses isolated from the far-eastern region of Russia and South Korea, but d

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Müller, M. H., N. Reimann-Berg, J. Bullerdiek, and H. Murua Escobar. "Genetic characterization of dogs via chromosomal analysis and array-based comparative genomic hybridization (aCGH)." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 40, no. 01 (2012): 55–58. http://dx.doi.org/10.1055/s-0038-1623620.

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SummaryThe results of cytogenetic and molecular cytogenetic investigations revealed similarities in genetic background and biological behaviour between tumours and genetic diseases of humans and dogs. These findings classify the dog a good and accepted model for human cancers such as osteosarcomas, mammary carcinomas, oral melanomas and others. With the appearance of new studies and advances in canine genome sequencing, the number of known homologies in diseases between these species raised and still is expected to increase. In this context, array-based comparative genomic hybridization (aCGH)

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Baum, Larry, and Eric Baum. "Progressive Diseases: Interpretation of Genetic Data." Journal of Theoretical Medicine 2, no. 1 (1999): 1–7. http://dx.doi.org/10.1080/17486709909490784.

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Simple modeling is proposed to represent the screening of gene polymorphisms for association with a progressive disease of insidious onset such as Alzheimer's disease. The modeling demonstrates that when a polymorphism affects the rate of progression as well as the risk of disease, the correct interpretation of DNA data requires an accurate sampling of the living, diseased population. Furthermore, in this population, the effect of the polymorphism on disease risk cannot be distinguished from a corresponding effect on the rate of progression of the disease, and a null result does not preclude a

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Wallis, Natalie, and Eleanor Raffan. "The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals." Genes 11, no. 11 (2020): 1378. http://dx.doi.org/10.3390/genes11111378.

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Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this r

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Le Poder, Sophie. "Feline and Canine Coronaviruses: Common Genetic and Pathobiological Features." Advances in Virology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/609465.

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A new human coronavirus responsible for severe acute respiratory syndrome (SARS) was identified in 2003, which raised concern about coronaviruses as agents of serious infectious disease. Nevertheless, coronaviruses have been known for about 50 years to be major agents of respiratory, enteric, or systemic infections of domestic and companion animals. Feline and canine coronaviruses are widespread among dog and cat populations, sometimes leading to the fatal diseases known as feline infectious peritonitis (FIP) and pantropic canine coronavirus infection in cats and dogs, respectively. In this pa

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Butler, Molly D., Karen Griffin, Connie D. Brewster, et al. "A Novel Retrovirus (Gunnison’s Prairie Dog Retrovirus) Associated With Thymic Lymphoma in Gunnison’s Prairie Dogs in Colorado, USA." Viruses 12, no. 6 (2020): 606. http://dx.doi.org/10.3390/v12060606.

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As part of research and wildlife disease surveillance efforts, we performed necropsy examinations of 125 free-ranging (n = 114) and captive (n = 11) prairie dogs in Colorado from 2009 to 2017. From these cases, we identified three cases of thymic lymphoma in free-ranging Gunnison’s prairie dogs (Cynomys gunnisoni), and we identified a novel retroviral sequence associated with these tumors. The viral sequence is 7700 nucleotides in length and exhibits a genetic organization that is consistent with the characteristics of a type D betaretrovirus. The proposed name of this virus is Gunnison’s prai

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Garbacz, K., L. Piechowicz, S. Żarnowska, K. Haras, and M. Dąbrowska-Szponar. "Heterogeneity of methicillin-sensitive Staphylococcus pseudintermedius strains isolated from diseased dogs." Polish Journal of Veterinary Sciences 14, no. 2 (2011): 283–84. http://dx.doi.org/10.2478/v10181-011-0043-6.

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Heterogeneity of methicillin-sensitive Staphylococcus pseudintermedius strains isolated from diseased dogs Thirty nine canine S. pseudintermedius strains were examined for antibiotic susceptibility and genetic polymorphisms. All strains were methicillin-sensitive S. pseudintermedius (MSSP). Resistance to penicillin was most prevalent (66.6%), followed by resistance to neomycin (56.4%), erythromycin (53.8%), clindamycin (48.7%), chloramphenicol (48.7%), and tetracycline (46.2%). Pulsed-field electrophoresis (PFGE) showed a high genetic polymorphism in the investigated strains.

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Conrads, Georg, Diane M. Citron, and Ellie J. C. Goldstein. "Genetic Determinant of Intrinsic Quinolone Resistance in Fusobacterium canifelinum." Antimicrobial Agents and Chemotherapy 49, no. 1 (2005): 434–37. http://dx.doi.org/10.1128/aac.49.1.434-437.2005.

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ABSTRACT Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine.

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Broeckx, B., E. Verelst, D. Deforce, et al. "Combined prevalence of inherited skeletal disorders in dog breeds in Belgium." Veterinary and Comparative Orthopaedics and Traumatology 27, no. 05 (2014): 395–97. http://dx.doi.org/10.3415/vcot-13-11-0140.

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SummaryCanine hip dysplasia (CHD), canine elbow dysplasia (CED), and humeral head osteochondrosis (HHOC) are inherited traits with uneven incidence in dog breeds. Knowledge of the combined prevalence of these three disorders is necessary to estimate the effect of the currently applied breeding strategies, in order to improve the genetic health of the population. Official screening results of the Belgian National Committee for Inherited Skeletal Disorders (NCSID) revealed that an average of 31.8% (CHD, CED, or both; n = 1273 dogs) and 47.2% (CHD, CED, HHOC, or a combination of these three disea

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Wang, Jinming, Junlong Liu, Jifei Yang, et al. "Molecular detection and genetic diversity of Babesia canis canis in pet dogs in Henan Province, China." Parasitology International 71 (August 2019): 37–40. http://dx.doi.org/10.1016/j.parint.2019.03.011.

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Machado, Mauro L. S., Claudia Cafarchia, Domenico Otranto, et al. "Genetic variability and phospholipase production ofMalassezia pachydermatisisolated from dogs with diverse grades of skin lesions." Medical Mycology 48, no. 6 (2010): 889–92. http://dx.doi.org/10.3109/13693780903532080.

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PÁEZ, A., C. SAAD, C. NÚÑEZ, and J. BÓSHELL. "Molecular epidemiology of rabies in northern Colombia 1994–2003. Evidence for human and fox rabies associated with dogs." Epidemiology and Infection 133, no. 3 (2005): 529–36. http://dx.doi.org/10.1017/s0950268805003699.

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During the period 2000–2003, wild grey foxes (Urocyon cinereoargenteus) in northern Colombia became infected with rabies. In order to derive phylogenetic relationships between rabies viruses isolated in foxes, dogs and humans in this region, 902 nt cDNA fragments containing the G–L intergenic region and encoding the cytoplasmic domain of protein G and a fragment of protein L were obtained by RT–PCR, sequenced and compared. Phylogenetic analysis showed that rabies viruses isolated in foxes, dogs and humans belonged to a single genetic variant. Speculative analysis together with epidemiological

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Rollin, Bernard. "“We Always Hurt the Things We Love”—Unnoticed Abuse of Companion Animals." Animals 8, no. 9 (2018): 157. http://dx.doi.org/10.3390/ani8090157.

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Despite the fact that companion animals enjoy the status of “members of the family” in contemporary society, there are numerous diseases affecting the longevity of these animals and their quality of life. Some of the most pervasive and damaging problems accrue to pedigreed animals whose genetic lines contain many major and severe diseases which are detrimental to both the quality and length of life. If one considers the most popular dog breeds in the United States, the top 10 include the Labrador Retriever, German Shepherd, Golden Retriever, French Bulldog, Beagle, Poodle, Rottweiler, Yorkshir

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Matsugo, Hiromichi, Tomoya Kobayashi-Kitamura, Haruhiko Kamiki, et al. "Establishment of a Simple and Efficient Reverse Genetics System for Canine Adenoviruses Using Bacterial Artificial Chromosomes." Viruses 12, no. 7 (2020): 767. http://dx.doi.org/10.3390/v12070767.

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Canine adenoviruses (CAdVs) are divided into pathotypes CAdV1 and CAdV2, which cause infectious hepatitis and laryngotracheitis in canid animals, respectively. They can be the backbones of viral vectors that could be applied in recombinant vaccines or for gene transfer in dogs and in serologically naïve humans. Although conventional plasmid-based reverse genetics systems can be used to construct CAdV vectors, their large genome size creates technical difficulties in gene cloning and manipulation. In this study, we established an improved reverse genetics system for CAdVs using bacterial artifi

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Mravcová, K., G. Štrkolcová, and M. Goldová. "The Prevalence and Assemblages of Giardia Duodenalis in Dogs: A Systematic Review in Europe." Folia Veterinaria 63, no. 4 (2019): 38–45. http://dx.doi.org/10.2478/fv-2019-0036.

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Abstract Giardiasis is one of the most frequent causes of diarrhoeic diseases in the world. Giardia cysts are most commonly transferred via ingestion of contaminated water or food. On the basis of genetic characteristics Giardia duodenalis is classified in eight assemblages A—H. Zoonotic assemblages A and B are increasingly found in isolates from dogs which may constitute the reservoir of human giardiasis. This article presents a brief review of G. duodenalis assemblages detected in dogs that were documented in European countries.

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Drążek-Kubiak, Magdalena, Marcin Lew, and Sylwia Lew. "Electroretinographic findings in day-blind dogs." Acta Veterinaria Hungarica 66, no. 2 (2018): 204–14. http://dx.doi.org/10.1556/004.2018.019.

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Cone degeneration (cd; day blindness) is one of the inherited retinal diseases of dogs. Its diagnosis is based on vision testing, fundoscopy, electroretinography (ERG) and, for some breeds, on genetic tests. Typical signs of the disease are day blindness and cone dysfunction during ERG while fundoscopy does not show any abnormalities. The aim of this study was to compare behavioural findings, fundoscopic lesions and electroretinographic alterations in 12 cd-affected dogs (Alaskan Malamute, Labrador Retriever, German Shepherd, Dachshund, Yorkshire Terrier, Shih Tzu, Siberian Husky and crossbree

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Šebková, N. Fiala, H. Chaloupková, and L. Zavadilová. "Average Life Expectancy, the Most Common Cause of Death and Illness of Giant Dog Breeds." Scientia Agriculturae Bohemica 51, no. 1 (2020): 9–14. http://dx.doi.org/10.2478/sab-2020-0002.

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AbstractThe aim of this study was to analyze the most common diseases and genetic defects that occur during the lifetime of giant dog breeds, to determine the average lifespan and the cause of death/euthanasia. Data were obtained through a survey and concerned the health of 241 individuals of giant dog breeds held in the Czech Republic. Evaluated items involved an average lifespan, an average lifespan per gender, cause of death, reasons for euthanasia, cause of mortality (especially in selected Mastiff type breeds), life expectancy per breed and incidence of diseases among giant breeds during

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Skotarczak, B. "Babesiosis as a disease of people and dogs. Molecular diagnostics: a review." Veterinární Medicína 53, No. 5 (2008): 229–35. http://dx.doi.org/10.17221/1946-vetmed.

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<I>Babesia</I> is the causative agent of babesiosis, a tick-borne zoonosis which has been increasingly described throughout the world. <I>Babesia microti</I> and <I>Babesia divergens</I> are the etiological agents of human babesiosis. <I>Babesia canis</I> is the principal etiological agent of canine babesiosis. Currently, the diagnostics of babesiosis is based mainly on serological methods and the immunofluorescent antibody test (IFA) is most commonly used. However, even in the acute phase of the disease, seroconversion does not always occur. Cli

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Townsley, Danielle M., Bogdan Dumitriu, Sachiko Kajigaya, Rodrigo T. Calado, Phillip Scheinberg, and Neal S. Young. "Clinical and Genetic Heterogeneity of Telomere Diseases." Blood 120, no. 21 (2012): 2373. http://dx.doi.org/10.1182/blood.v120.21.2373.2373.

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Abstract Abstract 2373 Genetic defects in telomerase genes are associated with a variety of clinical syndromes that includes marrow failure, cirrhosis and pulmonary fibrosis. Mutations in the RNA template (TERC) and the catalytic subunit (TERT) have been associated to adult onset aplastic anemia without the characteristic physical abnormalities observed in inherited forms of marrow failure where telomerase genes can be mutated. Clinical presentations can vary and a careful personal and family history often provides clues to an underlying telomeropathy. The implications for therapy are still ev

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ADDY, F., M. WASSERMANN, F. BANDA, et al. "Genetic polymorphism and population structure ofEchinococcus ortleppi." Parasitology 144, no. 4 (2016): 450–58. http://dx.doi.org/10.1017/s0031182016001840.

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SUMMARYThe zoonotic cestodeEchinococcus ortleppi(Lopez-Neyra and Soler Planas, 1943) is mainly transmitted between dogs and cattle. It occurs worldwide but is only found sporadically in most regions, with the notable exception of parts of southern Africa and South America. Its epidemiology is little understood and the extent of intraspecific variability is unknown. We have analysed in the present study the genetic diversity among 178E. ortleppiisolates from sub-Saharan Africa, Europe and South America using the complete mitochondrialcox1(1608 bp) andnad1(894 bp) DNA sequences. Genetic polymorp

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Miyadera, Keiko, Gregory M. Acland, and Gustavo D. Aguirre. "Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies." Mammalian Genome 23, no. 1-2 (2011): 40–61. http://dx.doi.org/10.1007/s00335-011-9361-3.

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Hadi, Moch Irfan, Muhammad Yusuf Alamudi, Mei Lina Fitri Kumalasari, et al. "Dogs (Canis lupus familiaris) as Virus Carrier in Indonesia." Biotropic : The Journal of Tropical Biology 2, no. 2 (2018): 100–107. http://dx.doi.org/10.29080/biotropic.2018.2.2.100-107.

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A Virus is an individual that cannot be described as an animal or a plant. If animals and plants contain two nucleic acids (DNA and RNA), on the contrary, the virus only has one of them. These nucleic acids can stimulate a complete virus replication cycle. The virus can only replicate and live on a living host if the host is finally dead, then the virus will move on the cells that are still alive. The virus has genetic material which is a protective protein coat called a capsid. Viruses can infect various varieties of organisms, both eukaryotes (animals, plants, protists, and fungi) and prokar

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Whittam, Thomas S., M. L. Wolfe, and R. A. Wilson. "Genetic relationships amongEscherichia coliisolates causing urinary tract infections in humans and animals." Epidemiology and Infection 102, no. 1 (1989): 37–46. http://dx.doi.org/10.1017/s0950268800029666.

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SUMMARYGenetic variation in isolates ofEscherichia coliobtained mostly from urinary tract infections in humans and domesticated animals (dogs and cats) was assessed for 16 enzymes using multilocus enzyme electrophoresis to characterize chromosomal genotypes. A total of 148 isolates comprised 63 distinct electrophoretic types (ETs) and about half of the isolates belonged to one of 9 common ETs. A bootstrap analysis of genetic distance between ETs revealed three significant groups of strains. Variation in allele frequencies among groups accounted for 40% of the total genetic diversity. The major

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Singh, M. N., O. K. Raina, M. Sankar, et al. "Molecular detection and genetic diversity of Babesia gibsoni in dogs in India." Infection, Genetics and Evolution 41 (July 2016): 100–106. http://dx.doi.org/10.1016/j.meegid.2016.03.025.

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Derakhshandeh, Abdollah, Vida Eraghi, Azar Motamedi Boroojeni, Malihe Akbarzadeh Niaki, Sahar Zare, and Zahra Naziri. "Virulence factors, antibiotic resistance genes and genetic relatedness of commensal Escherichia coli isolates from dogs and their owners." Microbial Pathogenesis 116 (March 2018): 241–45. http://dx.doi.org/10.1016/j.micpath.2018.01.041.

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Kuznetsova, T., A. Mikhailova, A. Markov, E. Filippova, and E. Bychkova. "Correlation analysis of clinical features and genotype in dogs with intervertebral disc degeneration." International bulletin of Veterinary Medicine 1 (2020): 128–34. http://dx.doi.org/10.17238/issn2072-2419.2020.1.128.

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Most modern pet species have awide breed variability. The genetic aspect plays a signif-icant role in the development of individual pathologies. A retrogen encoding fibroblast growth factor 4 (FGF4), when inserted into the chromosome 18of dogs (CFA18), leads to chondrodysplasia, phenotypically mani-festing itself as shortened limbs in dogs. The incorporation of the FGF4 retrogene into chromosome 12 (CFA12) leads to a similar phenotype, but associated with an increased degeneration of the intervertebral discs. Although many retrogens are considered “silent”pseudogenes, the FGF4 retrogene in cas

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TRAUB, R. J., P. T. MONIS, I. ROBERTSON, P. IRWIN, N. MENCKE, and R. C. A. THOMPSON. "Epidemiological and molecular evidence supports the zoonotic transmission ofGiardiaamong humans and dogs living in the same community." Parasitology 128, no. 3 (2004): 253–62. http://dx.doi.org/10.1017/s0031182003004505.

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Giardia duodenalisisolates recovered from humans and dogs living in the same locality in a remote tea-growing community of northeast India were characterized at 3 different loci; the SSU-rDNA, elongation factor 1-alpha (ef1-α) and triose phosphate isomerase (tpi) gene. Phylogenetic analysis of the SSU-rDNA and ef1-α genes provided poor genetic resolution of the isolates within various assemblages, stressing the importance of using multiple loci when inferring genotypes toGiardia. Analysis of the tpi gene provided better genetic resolution and placed canineGiardiaisolates within the genetic gro

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Arya, Subhash C. "Human contact with cattle, dogs and monkeys and genetic diversity of measles viruses." Comparative Immunology, Microbiology and Infectious Diseases 23, no. 2 (2000): 125–27. http://dx.doi.org/10.1016/s0147-9571(99)00064-8.

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Tayyub, Muhammad, Kamran Ashraf, Muhammad Lateef, et al. "Genetic Diversity of Canine Babesia Species Prevalent in Pet Dogs of Punjab, Pakistan." Animals 9, no. 7 (2019): 439. http://dx.doi.org/10.3390/ani9070439.

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Canine babesiosis is a serious threat to dogs’ health worldwide, caused by the intra-erythrocytic Babesia species. The present study was carried out in pet dogs presented at three clinics of Lahore and one of Narowal in Punjab, Pakistan. Two hundred blood samples (50 from each clinic) were collected and screened by microscopy for Babesia spp. Out of 200 samples, 84 (42%) were found to be positive for babesiosis. The highest number of positive cases (50%) was recorded in dogs at Narowal clinic. Non-significant variation (p > 0.05) was observed in the prevalence of babesiosis in dogs in relat

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CHARALAMBOUS (Μ. ΧΑΡΑΛΑΜΠΟΥΣ), M., T. DANOURDIS (Τ. ΔΑΝΟΥΡΔΗΣ), A. HATZIS (Α. ΧΑΤΖΗΣ), and Z. S. POLIZOPOULOU (Ζ. ΠΟΛΥΖΟΠΟΥΛΟΥ). "An update on meningoencephalomyelitis of unknown aetiology in dogs." Journal of the Hellenic Veterinary Medical Society 64, no. 2 (2017): 131. http://dx.doi.org/10.12681/jhvms.15486.

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Inflammatory diseases of the central nervous system are common causes of neurological dysfunction in the dog and can be grouped into two broad categories; those of infectious and those of unknown aetiology. Μeningoencephalomyelitis of unknown aetiology include non-infectious inflammatory central nervous system diseases in which abnormal findings on magnetic resonance imaging and cerebrospinal fluid analysis indicate inflammatory central nervous system disease, but for which histopathological confirmation has not been reached. Meningoencephalomyelitis of unknown aetiology describes a group of n

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Dumonteil, Eric, Ardem Elmayan, Alicia Majeau, et al. "Genetic diversity of Trypanosoma cruzi parasites infecting dogs in southern Louisiana sheds light on parasite transmission cycles and serological diagnostic performance." PLOS Neglected Tropical Diseases 14, no. 12 (2020): e0008932. http://dx.doi.org/10.1371/journal.pntd.0008932.

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Background Chagas disease is a neglected zoonosis of growing concern in the southern US, caused by the parasite Trypanosoma cruzi. We genotyped parasites in a large cohort of PCR positive dogs to shed light on parasite transmission cycles and assess potential relationships between parasite diversity and serological test performance. Methodology/principal findings We used a metabarcoding approach based on deep sequencing of T. cruzi mini-exon marker to assess parasite diversity. Phylogenetic analysis of 178 sequences from 40 dogs confirmed the presence of T. cruzi discrete typing unit (DTU) TcI

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Hoang, Minh, Cheng-Nan Wu, Chuen-Fu Lin, et al. "Genetic characterization of feline panleukopenia virus from dogs in Vietnam reveals a unique Thr101 mutation in VP2." PeerJ 8 (October 12, 2020): e9752. http://dx.doi.org/10.7717/peerj.9752.

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Background Canine parvovirus type 2 (CPV-2) and feline parvovirus (FPV) are known as the main causes of several serious diseases and have a severe impact on puppies and kittens, respectively. FPV and new CPV-2 variants are all able to infect cats, causing diseases indistinguishable from feline panleukopenia. However, FPV only replicates efficiently in feline cells in vitro and replicates in dogs in the thymus and bone marrow without being shed in feces. In our previous study, the genotypes of six parvoviral isolates were unable to be identified using a SimpleProbe® real-time PCR assay. Methods

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Corral, Cheryl. "DNA profiling and personalised medicine from Nationwide Laboratories." Companion Animal 25, no. 11 (2020): 298–303. http://dx.doi.org/10.12968/coan.2020.0092.

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Research into the canine genome has made it possible to test and screen for inherited diseases occurring as a result of single-gene mutations with ease. Nationwide Laboratories have used developments in the availability of these tests to develop DNA profiling for cats and dogs, with the option to include a life plan for the patient alongside the results. The hope is that screening cats and dogs early in life would allow for lifestyle adaptations and treatment planning, to allow for better management of any potential genetic disease, improving the overall healthcare for the companion animal as

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Corral, Cheryl. "DNA profiling and personalised medicine from Nationwide Laboratories." Veterinary Nurse 11, no. 10 (2020): 466–71. http://dx.doi.org/10.12968/vetn.2020.11.10.466.

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Research into the canine genome has made it possible to test and screen for inherited diseases occurring as a result of single-gene mutations with ease. Nationwide Laboratories have used developments in the availability of these tests to develop DNA profiling for cats and dogs, with the option to include a life plan for the patient alongside the results. The hope is that screening cats and dogs early in life would allow for lifestyle adaptations and treatment planning, to allow for better management of any potential genetic disease, improving the overall healthcare for the companion animal as

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Castelli, Germano, Federica Bruno, Valentina Caputo, et al. "Genetic tools discriminate strains of Leishmania infantum isolated from humans and dogs in Sicily, Italy." PLOS Neglected Tropical Diseases 14, no. 7 (2020): e0008465. http://dx.doi.org/10.1371/journal.pntd.0008465.

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Letko, Anna, Elisabeth Dietschi, Marco Nieburg, et al. "A Missense Variant in SCN8A in Alpine Dachsbracke Dogs Affected by Spinocerebellar Ataxia." Genes 10, no. 5 (2019): 362. http://dx.doi.org/10.3390/genes10050362.

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Spinocerebellar ataxias is an umbrella term for clinically- and neuropathologically-heterogeneous early-onset hereditary neurodegenerative diseases affecting several dog breeds. The purpose of this study is to identify the causative genetic variant associated with ataxia, tremor, and loss of balance in Alpine Dachsbracke dogs. We investigated two related litters in which four cases were reported. Neuropathology of two dogs revealed spongy degeneration associated with axonal degeneration. Combined genetic linkage and autozygosity analyses in four cases and eight related controls showed one crit

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Corbee, Ronald Jan, and Louis C. Penning. "COMMD1 Exemplifies the Power of Inbred Dogs to Dissect Genetic Causes of Rare Copper-Related Disorders." Animals 11, no. 3 (2021): 601. http://dx.doi.org/10.3390/ani11030601.

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Wilson’s Disease is a rare autosomal recessive disorder in humans, often presenting with hepatic copper overload. Finding the genetic cause of a rare disease, especially if it is related to food constituents like the trace element copper, is a Herculean task. This review describes examples of how the unique population structure of in-bred dog strains led to the discovery of a novel gene and two modifier genes involved in inherited copper toxicosis. COMMD1, after the discovery in 2002, was shown to be a highly promiscuous protein involved in copper transport, protein trafficking/degradation, re

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Jahns, Hanne, Karen M. Vernau, Catherine M. Nolan, Emma J. O’Neill, Robert E. Shiel, and G. Diane Shelton. "Polyneuropathy in Young Siberian Huskies Caused by Degenerative and Inflammatory Diseases." Veterinary Pathology 57, no. 5 (2020): 666–74. http://dx.doi.org/10.1177/0300985820934112.

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Polyneuropathy is defined as the simultaneous dysfunction of several peripheral nerves. In dogs, a number of breeds are predisposed to a variety of immune-mediated and/or degenerative inherited forms of polyneuropathy, with laryngeal paralysis and/or megaesophagus as important clinical features of many of these conditions. This case series describes degenerative and inflammatory polyneuropathies in 7 young Siberian huskies that were categorized based on clinicopathological characteristics as follows: (1) slowly progressive laryngeal paralysis and megaesophagus caused by primary axonal degenera

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