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Relevant bibliographies by topics / Genetic Epistasis / Dissertations / Theses

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Dissertations / Theses on the topic 'Genetic Epistasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Bell, Jordana Tzenova. "Epistasis in complex human traits." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:547db446-c84c-4a6c-8b5c-ce960f7765c5.

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2

Ferreira, Teresa. "Statistical methods for modelling epistasis in genetic association studies." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543476.

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3

Balyan, Prachi. "Complex genetic interactions in the model eukaryote, Saccharomyces cerevisiae." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709165.

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Oliveira, Paulo Tadeu Meira e. Silva de. "Aplicação do algorítmo genético no mapeamento de genes epistáticos em cruzamentos controlados." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-29092008-110907/.

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O mapeamento genético é constituído por procedimentos experimentais e estatísticos que buscam detectar genes associados à etiologia e regulação de doenças, além de estimar os efeitos genéticos e as localizações genômicas correspondentes. Considerando delineamentos experimentais que envolvem cruzamentos controlados de animais ou plantas, diferentes formulações de modelos de regressão podem ser adotados na identificação de QTLs (do inglês, quantitative trait loci), incluindo seus efeitos principais e possíveis efeitos de interação (epistasia). A dificuldade nestes casos de mapeamento é a compara

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Morais, Alexandre Augusto de. "Epistasia na herança da resistência do milho ao gorgulho Sitophilus zeamais (Coleoptera: Curculionidae)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-18092012-103000/.

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Considerado um dos aspectos mais complexos da genética quantitativa, a epistasia tem sido ignorada pelos melhoristas nos estudos de herança dos caracteres, principalmente os da herança da resistência de plantas a insetos, que são de difícil obtenção. No milho, a principal praga de grãos é o Sitophilus zeamais (Coleoptera: Curculionidae), devido a sua capacidade de atacar grãos tanto no campo quanto em silos. Contudo, as estimativas dos componentes aditivo e de dominância envolvidos na herança dessa resistência podem estar viesadas pela presença do efeito da epistasia. Utilizando o delineamento

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Scoville, Alison G. "Phenotypic Plasticity and the Post-Modern Synthesis: Integrating Evo-Devo and Quantitative Genetics in Theoretical and Empirical Studies." DigitalCommons@USU, 2008. https://digitalcommons.usu.edu/etd/212.

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Mainstream evolutionary biology lacks a mature theory of phenotype. Following from the Modern Synthesis, researchers tend to assume an unrealistically simple mapping of genotype to phenotype, or else trust that the complexities of developmental architecture can be adequately captured by measuring trait variances and covariances. In contrast, the growing field of evolutionary developmental biology (evo-devo) explicitly examines the relationship between developmental architecture and evolutionary change, but lacks a rigorous quantitative and predictive framework. In my dissertation, I strive

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Chen, Anlu. "Applying Forward Genetic Approaches to Rare Mendelian Disorders and Complex Traits." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1532522241487661.

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8

Ali, Abdirahman. "Quantitative genetics and genomics of production and disease in beef cattle." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/12296.

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Cattle grazing in extensive open pasture of tropical areas are subjected to several environmental stressors such as heat and humidity, high incidence of disease, cattle ticks and worm infestations. These stressors have major impacts on productivity and animal welfare. The overall focus of this PhD thesis was to conduct classical genetic and modern quantitative genomics analyses for growth and carcass related traits, and disease and parasite tolerance/resistance traits in beef cattle. The specific objectives were: (1) to estimate genetic parameters for growth, carcass related traits, and tropic

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9

FacÃ, Olivardo. "Estudo genÃtico-quantitativo com os grupos genÃticos formadores da raÃa Girolanda." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4552.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A partir de dados de genealogia, produÃÃo de leite e registro de partos de animais de vÃrios grupos genÃticos HolandÃs x Gir, obtidos junto Ã AssociaÃÃo Brasileira dos Criadores de Girolando, foram realizados trÃs estudos. No primeiro estudo foram investigados os efeitos do tratamento das informaÃÃes de duraÃÃo da lactaÃÃo sobre variabilidade genÃtica para a produÃÃo de leite em animais de vÃrios grupos genÃticos HolandÃs x Gir. Estimativas dos componentes de (co)variÃncia foram obtidas por meio do mÃtodo da mÃxima verossimilhanÃa

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10

Good, Jeffrey. "The Genetic Basis of Reproductive Isolation Between Two Species of House Mice." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195901.

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Determining the genetic basis of reproductive isolation is a fundamental goal in evolutionary biology. Intrinsic reproductive isolation often arises due to epistasis between divergent interacting genes. The rapid evolution of hybrid male sterility is known to have several causes, including the exposure of recessive X-linked incompatibilities in males and the rapid evolution of male reproductive traits. Despite these insights, little is known about the genetics of reproductive isolation during the early stages of speciation. This deficiency inspired parallel studies on the molecular evoluti

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11

Banerjee, Samprit. "Bayesian genome-wide QTL mapping for multiple traits." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/banerjee.pdf.

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12

Hemani, Gibran. "Dissecting genetic interactions in complex traits." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6472.

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Of central importance in the dissection of the components that govern complex traits is understanding the architecture of natural genetic variation. Genetic interaction, or epistasis, constitutes one aspect of this, but epistatic analysis has been largely avoided in genome wide association studies because of statistical and computational difficulties. This thesis explores both issues in the context of two-locus interactions. Initially, through simulation and deterministic calculations it was demonstrated that not only can epistasis maintain deleterious mutations at intermediate frequencies whe

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13

Grange, Laura. "Epistasis in genetic susceptibility to infectious diseases : comparison and development of methods application to severe dengue in Asia." Paris 7, 2014. http://www.theses.fr/2014PA077088.

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Ce travail est dédié à l'étude de l'épistasie dans la prédisposition génétique aux maladies complexes. Il existe de nombreuses méthodes dédiées à la détection de telles interactions. Le plus souvent, l'évaluation de ces méthodes utilise différentes procédures ce qui empêche la comparaison des études entre elles. Nous avons réalisé une étude comparative des performances de quelques méthodes de recherches d'interaction sur génome entier (GWIS), en particulier BOOST, MBMDR, PLINK et EPIBLASTER. Dans un deuxième projet, nous avons développé et évalué une méthode de détection de l'épistasie basée s

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14

Forsberg, Simon. "Complex Trait Genetics : Beyond Additivity." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-307837.

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The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. Using experimental data from three different model organisms, I study two phenomena that fall outside of the additive paradigm: genetic interactions and genetic variance heterogeneity. Using the model plant Arabidopsis thaliana, we show how important biological insights can

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15

Söylemez, Onuralp 1985. "On the prevalence and role of epistasis in shaping fitness within and between populations." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398380.

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The role of epistasis – inter-dependent contributions of alleles to fitness – in shaping genetic variation within and between populations is an important question in evolutionary biology with significant implications for our understanding of the factors contributing to phenotypic variation. While epistasis has been shown to play an important role in evolutionary processes such as speciation and adaptive evolution, many aspects of this role remains poorly understood. In particular, there is much debate on whether observing prevalent epistasis in evolution can be taken as evidence for functional

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Silva, Diego Velásquez Faleiro e. "Epistasia em testecrosses de milho." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-13092011-081029/.

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A epistasia já é conhecida desde o início dos estudos em genética, porém sua contribuição para as estimativas dos componentes da variância genética e para o melhoramento genético ainda não é bem entendida. A maioria dos modelos usados para estudar a herança dos caracteres quantitativos considera apenas os efeitos genéticos aditivos e de dominância, assumindo ausência da epistasia, mesmo que as análises não forneçam testes para tal suposição. Portanto, na sua presença, estimativas de variância aditiva e dominância, coeficientes de herdabilidade e respostas esperadas com a seleção estão viesadas

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Phenix, Hilary. "Derivation and Use of Gene Network Models to Make Quantitative Predictions of Genetic Interaction Data." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/37031.

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This thesis investigates how pairwise combinatorial gene and stimulus perturbation experiments are conducted and interpreted. In particular, I investigate gene perturbation in the form of knockout, which can be achieved in a pairwise manner by SGA or CRISPR/Cas9 methods. In the present literature, I distinguish two approaches to interpretation: the calculation of stimulus and gene interactions, and the identification of equality among phenotypes measured for distinct perturbation conditions. I describe how each approach has been applied to derive hypotheses about gene regulatory networks. I id

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18

Rünneburger, Estelle. "Évolution de la canalisation génétique dans un modèle quantitatif de réseau de régulation." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS547/document.

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La canalisation génétique est définie comme la capacité d’un organisme à avoir un développement constant en dépit des mutations qui l’affectent. A l’heure actuelle, trois hypothèses majoritaires cherchent à expliquer l’apparition de ce processus : évolutive, congruente et intrinsèque. Pour tester ces hypothèses, j’ai choisi d’étudier les réseaux de régulation. Pour cela, j’ai réutilisé un modèle théorique pour simuler in silico l’évolution des architectures génétiques, et les analyser par les outils de la génétique quantitative. J’ai d’abord étudié les comportements évolutifs de notre modèle e

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Neto, José Osório de Oliveira Azevedo. "Troost - Busca de interações entre trios de SNPs em estudos de associação de genoma inteiro." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-09022014-090547/.

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Os estudos de associação de genoma inteiro têm encontrado alguns marcadores associados a doenças notoriamente hereditárias com herança complexa, mas, muitas vezes, estes marcadores somente explicam uma pequena parte da herdabilidade. Este relativo insucesso é atribuído, entre outras causas, à epistasia, ou seja, interação entre diferentes locos genéticos. A busca por epistasia é complexa e exige intensos recursos computacionais. Diversos métodos têm sido propostos para abordar este problema, incluindo métodos estatísticos tradicionais, busca estocástica e métodos heurísticos. Poucos destes mét

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20

Tavera, Gloria. "Helicobacter pylori Genetic Variation and Gastric Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1565176211647636.

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Hallin, Johan Henning. "Élucider les facteurs génétiques à l'origine de la variabilité des populations par phénomique et génomique de masse." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4010/document.

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La variabilité phénotypique existante au sein d’une population est d’une importance cruciale ; elle permet l’adaptation à de nouvelles conditions par la sélection naturelle de traits bénéfiques. La variabilité phénotypique est le résultat du polymorphisme génétique de chaque individu, couplé à l’influence de divers facteurs environnementaux. Ces travaux ont pour objectif d’élucider quels sont les facteurs génétiques responsables de la variabilité phénotypique de chaque individu afin de comprendre comment celle-ci évolue de génération en génération et peut s’accentuer au-delà des prédisposition

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22

Rio, Simon. "Contributions to genomic selection and association mapping in structured and admixed populations : application to maize." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS097.

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L'essor des marqueurs moléculaires (SNPs) a révolutionné les méthodes de génétique quantitative en permettant l'identification de régions impliquées dans le déterminisme génétique des caractères (QTLs) via la génétique d'association (GWAS), ou encore la prédiction des performances d'individus sur la base de leur information génomique (GS). La stratification des populations en groupes génétiques est courante en sélection animale et végétale. Cette structure peut impacter les méthodes de GWAS et de GS via des différences de fréquence et d'effets des allèles des QTL, ainsi que par des différences

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Hallin, Johan Henning. "Élucider les facteurs génétiques à l'origine de la variabilité des populations par phénomique et génomique de masse." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4010.

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La variabilité phénotypique existante au sein d’une population est d’une importance cruciale ; elle permet l’adaptation à de nouvelles conditions par la sélection naturelle de traits bénéfiques. La variabilité phénotypique est le résultat du polymorphisme génétique de chaque individu, couplé à l’influence de divers facteurs environnementaux. Ces travaux ont pour objectif d’élucider quels sont les facteurs génétiques responsables de la variabilité phénotypique de chaque individu afin de comprendre comment celle-ci évolue de génération en génération et peut s’accentuer au-delà des prédisposition

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Waksmunski, Andrea Rose. "From Variants to Pathways: Interrogating the Genetic Architecture of Age-Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586371907365746.

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Karbalai, Mirza Agha Nazanin [Verfasser], Bertram [Akademischer Betreuer] [Gutachter] Müller-Myhsok, and Hans-Werner [Gutachter] Mewes. "Identification of genetic variants involved in dyslexia pathogenesis by joint analysis of QTLs and epistasis / Nazanin Karbalai Mirza Agha ; Gutachter: Bertram Müller-Myhsok, Hans-Werner Mewes ; Betreuer: Bertram Müller-Myhsok." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1125626852/34.

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Bashir-Tanoli, Sumayia. "Impact of mitochondrial genetic variation and immunity costs on life-history traits in Drosophila melanogaster." Thesis, University of Stirling, 2014. http://hdl.handle.net/1893/21855.

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Immune activation is generally acknowledged to be costly. These costs are frequently assumed to result from trade-offs arising due to the reallocation of resources from other life-history traits to be invested in immunity. Here, I investigated the energetic basis of the costs associated with immune activation in Drosophila melanogaster. I found that immune activation significantly reduced fly fecundity (45%) and also caused a decline in metabolic rate (6%) but had no effect on body weight. To understand the factors behind reduced fecundity and metabolic rate I measured feeding and found that f

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Luo, Yuqun. "Incorporation of Genetic Marker Information in Estimating Modelparameters for Complex Traits with Data From Large Complex Pedigrees." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039109696.

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Ebbert, Mark T. "Role of Epistasis in Alzheimer's Disease Genetics." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4325.

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Alzheimer's disease is a complex neurodegenerative disease whose basic etiology and genetic structure remains elusive, despite decades of intensive investigation. To date, the significant genetic markers identified have no obvious functional effects, and are unlikely to play a role in Alzheimer's disease etiology, themselves. These markers are likely linked to other genetic variations, rare or common. Regardless of what causal mutations are found, research has demonstrated that no single gene determines Alzheimer's disease development and progression. It is clear that Alzheimer's disease devel

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Negrão, André Brooking. "Variantes genéticas de risco para a dependência de crack/cocaína: estudo de associação do tipo gene candidato e epistasia." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-25052012-143844/.

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O uso da cocaína e do crack tornou-se um problema de saúde pública importante no Brasil por conta de prejuízos significativos do ponto de vista médico, psicológico e social que ele acarreta. Estudos de gêmeos e, em famílias, sugerem que a dependência de cocaína é uma doença complexa, com participação importante de fatores genéticos. Os estudos genéticos sobre usuários de cocaína são poucos e padecem de problemas metodológicos, tais como, amostras pequenas, com alto grau de miscigenação populacional e um número limitado de marcadores genéticos pesquisados. Além disto, há pouco sendo feito no se

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MELCHIOTTI, ROSSELLA. "SNP association and epistasis in immune cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52441.

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The connection between genotype and phenotype is not straightforward due to the multiple mechanisms through which DNA mutations can affect phenotypic manifestations and the numerous ways polymorphisms can interact to produce a final outcome. This is particularly true for the immune system which is characterized by a complex interplay between multiple cell subsets. For this project we adopted a knowledge driven approach for the identification of association and epistasis events in the context of immune cells and immune diseases. The aim of our work was two-fold: to characterize the influence o

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Corbett-Detig, Russ Brendan. "Next-Generation Population Genomics: Inversion Polymorphisms, Segregation Distortion and Fitness Epistasis." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11528.

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Although population genetics has a long history and firm theoretical basis, until recently little data was available for empirical hypothesis testing. The unprecedented growth of sequencing methodologies has transformed the discipline from data-poor and theory rich field into one virtually unlimited by the available of suitable data. In this thesis, we develop bioinformatic methods to address a variety of longstanding questions in the field of evolutionary genetics. Specifically, we use data derived from model organisms to study the evolution of inversion polymorphisms, segregation distorters

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Wambach, Tina. "Effects of epistatic interaction on detection and parameter analysis of quantitative trait loci." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33039.

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Recent scientific support for the involvement of genetic locus interaction in quantitative trait variation and the widespread use of quantitative trait locus (QTL) mapping has resulted in the need to examine those aspects concurrently. Computer software was written to simulate interacting quantitative trait loci (QTLs) in plant populations. Using this software, interacting QTLs were simulated to examine effects of epistasis on the detection of QTLs and the quality of QTL parameter estimates. Simulations involved doubled haploid populations exhibiting two non-epistatic traits and seven epistati

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Atkinson, Alexandre. "Contribution à l'identification de facteurs de résistance au paludisme à Plasmodium fasciparum chez l'homme : Analyses d'association familiale et d'interaction génétique de l'IL12B, de HS3ST3A1, de HS3ST3B1 et de l'HBB." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22049/document.

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Le paludisme tue un enfant toutes les 30 secondes en Afrique et 1 à 3 millions de personnes par an. Deux milliards d'individus sont exposés et on estime à 500 millions le nombre de cas cliniques survenant chaque année. Le paludisme étant une maladie multifactorielle, son évolution est soumise à l'influence d'effets environnementaux, à des variables telles que l'âge de l'individu, ainsi qu'à une combinaison de facteurs génétiques. De nombreux arguments sont en faveur d’un contrôle génétique de la résistance au paludisme, mais les gènes impliqués restent encore mal connus. Afin d’identifier de n

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Jiang, Pan-Pan. "Patterns of molecular evolution and epistasis on a genomic and genic scale." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10771.

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Epistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.

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Garcia-Mendoza, Pedro José. "Epistasia para a produção de grãos e seus componentes em milho." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-20122011-090331/.

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O conhecimento dos diferentes fatores genéticos que afetam os caracteres quantitativos de importância agronômica é um pré-requisito importante para o planejamento dos programas de melhoramento genético que visam explorar de maneira eficiente a variabilidade genética disponível nas populações. A importância da epistasia no melhoramento genético das populações de milho ainda não é bem entendida, sendo assim ignorada na maioria dos estudos de herança dos caracteres de interesses para os melhoristas. Os objetivos deste trabalho foram: (i) verificar a importância da epistasia para produção de grãos

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Hall, Anne Elizabeth. "Adaptation, Epistasis, and Their Relationship with Metabolic Environment in Escherichia coli." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374252952.

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Díaz, Rubén José Silva. "Epistasia para a produção de grãos e caracteres da planta em milho." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-13022012-111248/.

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É conhecido que a epistasia pode ter um efeito importante na dinâmica das populações e no processo evolutivo das espécies e que está envolvida na manifestação de fenômenos biológicos importantes, tais como sobredominância, depressão por endogamia e heterose. No entanto, a epistasia é considerada como um dos aspectos mais complexos da genética quantitativa, uma vez que há limitada informação sobre os seus efeitos nos caracteres quantitativos. As estimativas dos componentes genéticos da variação, através de métodos que desconsideram a epistasia, podem estar viesadas; assim, interpretações de par

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Horstman, Benjamin Philip. "Detecting Epistasis Effect in Genome-Wide Association Studies Based on Permutation Tests and Ensemble Approaches." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270577390.

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Thesis (Master of Sciences (Engineering))--Case Western Reserve University, 2010<br>Department of EECS - Computer and Information Sciences Title from PDF (viewed on 2010-05-25) Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center

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Kerje, Susanne. "Mapping Genes Affecting Phenotypic Traits in Chicken." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3776.

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<p>The purpose of gene mapping is to understand the underlying genetics of simple and complex traits like plumage colour and growth. This thesis is based on a cross between the wild ancestor of the modern chicken, the red junglefowl, and a White Leghorn line selected for high egg mass. There are obvious phenotypic differences between these two breeds in several aspects such as growth, egg production and behaviour. These complex traits are often influenced by a number of genes or Quantitative Trait Loci (QTL) as well as environmental factors.</p><p>Identification of QTL regions involves testing

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Neira, Gonzalez Lara Andrea. "Studying the ability of finding single and interaction effects with Random Forest, and its application in psychiatric genetics." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31337.

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Psychotic disorders such as schizophrenia and bipolar disorder have a strong genetic component. The aetiology of psychoses is known to be complex, including additive effects from multiple susceptibility genes, interactions between genes, environmental risk factors, and gene by environment interactions. With the development of new technologies such as genome-wide association studies and imputation of ungenotyped variants, the amount of genomic data has increased dramatically leading to the necessary use of Machine Learning techniques. Random Forest has been widely used to study the underlying g

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Kunkel, Joseph. "A Systems Approach for Dissecting Integrated Signaling Pathways: TORC1 and Ras/PKA Regulation of Glucose Induced Growth Control in S. cerevisiae." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578637.

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One of the leading aims of systems biology is the complete delineation of the organization and architecture of signaling networks. Within this aim, characterizing integrated circuits is a particular challenge. Integrated circuits are the sites of information multiplexing, where input from multiple sources are combined into a single output or channel. A number of quantitative methods for analyzing epistasis within integrated pathways have been developed, with limited success. Here I present Expression Component Analysis, a novel approach for determining quantitative epistasis within an integrat

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Bertoli, Claudia Damo. "Modelos e metodologias para estimação dos efeitos genéticos fixos em uma população multirracial Angus x Nelore." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/128116.

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Os objetivos deste trabalho foram estimar os efeitos genéticos fixos atuando sobre uma população sintética e testar diferentes modelos e metodologias neste processo de estimação. Os efeitos genéticos fixos testados foram os efeitos aditivos direto e materno de raça e não aditivos diretos e maternos de heterose, perdas epistáticas e complementariedade. Os modelos testados incluem alternada e conjuntamente todos estes efeitos. As metodologias de regressão de cumeeira e regressão por quadrados mínimos foram comparadas assim como dois métodos distintos para determinação do ridge parameter. Uma pop

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Flury, Christine. "Epistatic kinship a new measure for the assessment of genetic diversity in livestock populations /." Doctoral thesis, [S.l.] : [s.n.], 2006. http://webdoc.sub.gwdg.de/diss/2006/flury.

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Araujo, Paulo Alencar de. "Detecção da epistasia para produção de grãos e caracteres agronômicos em soja." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-05022007-163336/.

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O conhecimento da base genética dos caracteres é muito importante para orientar os melhoristas quanto às estratégias a serem utilizadas visando uma maior eficiência dos programas de seleção. Para os caracteres quantitativos, o estudo da base genética dos mesmos é geralmente feito através de estimativas de componentes de variância. A maioria dos delineamentos genéticos disponíveis permite estimar a variância genética aditiva e a variância genética dominante. Poucos delineamentos permitem detectar a ocorrência de epistasia e, consequentemente o componente epistático da variância genética. O obje

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Meijsen, Joeri Jeroen. "Combining genome-wide association studies, polygenic risk scores and SNP-SNP interactions to investigate the genomic architecture of human complex diseases : more than the sum of its parts." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33094.

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Major Depressive Disorder is a devastating psychiatric illness with a complex genetic and environmental component that affects 10% of the UK population. Previous studies have shown that that individuals with depression show poorer performance on measures of cognitive domains such as memory, attention, language and executive functioning. A major risk factor for depression is a higher level of neuroticism, which has been shown to be associated with depression throughout life. Understanding cognitive performance in depression and neuroticism could lead to a better understanding of the aetiology o

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Chen, Carla Chia-Ming. "Bayesian methodology for genetics of complex diseases." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43357/1/Carla_Chen_Thesis.pdf.

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Genetic research of complex diseases is a challenging, but exciting, area of research. The early development of the research was limited, however, until the completion of the Human Genome and HapMap projects, along with the reduction in the cost of genotyping, which paves the way for understanding the genetic composition of complex diseases. In this thesis, we focus on the statistical methods for two aspects of genetic research: phenotype definition for diseases with complex etiology and methods for identifying potentially associated Single Nucleotide Polymorphisms (SNPs) and SNP-SNP interacti

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Cormier, Fabien. "Nitrogen use efficiency inwheat in bread wheat (T. aestivum L.) : breeding & gene discovery." Thesis, Clermont-Ferrand 2, 2015. http://www.theses.fr/2015CLF22574/document.

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Dans un contexte de réduction des intrants agricoles, la création de variétés de blé qui utilisent l’azote de manière plus efficiente est aujourd’hui nécessaire. Cette thèse, issue d'un partenariat public-privé entre l'Institut National de la Recherche Agronomique et Biogemma, avait pour but d'apporter des outils nécessaires à la création de variétés répondant à cette exigence. Pour ce faire, nous avons analysé 225 variétés commerciales génotypées avec 24K SNP et testées dans huit combinaisons d’année, lieu et régime azoté. Nous avons montré que même si la sélection a amélioré l’efficience d’u

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Xiang, Wenwen. "Identification of two interacting quantitative trait loci controlling for condensed tannin in sorghum grain and grain quality analysis of a sorghum diverse collection." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2359.

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Duthie, Carol-Anne. "Individual and epistatic genetic effects of quantitative trait loci affecting growth, feed intake, body composition and meat quality in pigs." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3875.

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Selection of pigs has focussed on the improvement of lean growth with simultaneous reduction in fat tissue, due to the high economic importance of these traits. As a consequence, a large number of quantitative trait loci (QTL) have been reported for these traits. In contrast, very few QTL have been reported for chemical body composition (protein and lipid). Knowledge about the deposition rates of these components is important to accurately predict the nutritional requirements of pigs and to determine selection objectives for optimal development of body tissues and feed intake capacity. Therefo

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Kawale, Ajinkya S. "PROCESSING OF 3′-BLOCKED DNA DOUBLE-STRAND BREAKS BY TYROSYL-DNA PHOSPHODIESTERASE 1, ARTEMIS AND POLYNUCLEOTIDE KINASE/ PHOSPHATASE." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5329.

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DNA double-strand breaks (DSBs) containing unligatable termini are potent cytotoxic lesions leading to growth arrest or cell death. The Artemis nuclease and tyrosyl-DNA phosphodiesterase (TDP1) are each capable of resolving protruding 3′-phosphoglycolate (PG) termini of DNA double-strand breaks (DSBs). Consequently, a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3′-PG-terminated DSBs. Unexpectedly, however, a knockdown or knockout of TDP1 in Artemis-null cells did not confer any greater sensitivit

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