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Relevant bibliographies by topics / Genetic recombination. Recombinant proteins. Recombinant DNA / Dissertations / Theses

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Dissertations / Theses on the topic 'Genetic recombination. Recombinant proteins. Recombinant DNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Houston, Peter Louis. "Biochemical characterization of genetic recombination proteins /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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2

Kepple, Kevin V. "Analysis of the binding mechanisms and cellular targets of peptide inhibitors that block site-specific recombination in vitro /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208620.

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3

Forget, Anthony L. "Homologous Recombinational DNA Repair: from Prokaryotes to Eukaryotes: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/68.

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The error free repair of DNA double strand breaks through the homologous recombinational repair pathway is essential for organisms of all types to sustain life. A detailed structural and mechanistic understanding of this pathway has been the target of intense study since the identification of bacterial recA, the gene whose product is responsible for the catalysis of DNA strand exchange, in 1965. The work presented here began with defining residues that are important for the assembly and stability of the RecA filament, and progressed to the identification of residues critical for the transfer o

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4

Zhekov, Ivailo. "Dissection of a functional interaction between the XerD recombinase and the DNA translocase FtsK." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572642.

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Successful bacterial circular chromosome segregation requires that any dimeric chromosomes, which arise by crossing over during homologous recombination, are converted to monomers. Resolution of dimers to monomers requires the action of the XerCD site-specific recombinase at dif in the chromosome replication terminus region. This reaction requires the DNA translocase, FtsK(C), which activates dimer resolution by catalysing an ATP hydrolysis-dependent switch in the catalytic state of the nucleoprotein recombination complex. We show that a 62-amino-acid fragment of FtsK(C) interacts directly wit

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5

Grip, Stefan. "Artificial spider silk : recombinant production and determinants for fiber formation /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health and Dept. of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/2008100.pdf.

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6

Selva, Erica Marie. "Mismatch Repair Acts As a Barrier to Homeologous Recombination in Saccharomyces cerevisiae: A Dissertation." eScholarship@UMMS, 1996. https://escholarship.umassmed.edu/gsbs_diss/61.

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Homeologous recombination refers to genetic exchanges between DNA partners containing similar but not identical DNA sequences. Heteroduplex intermediates in such exchanges are expected to contain multiple DNA mismatches at positions of sequence divergence and hence are potential targets for mismatch correction. Thus recombination of this type is of particular interest in understanding the role of DNA mismatch correction on recombination fidelity. Previous studies that examined this question in prokaryotic systems suggested that mismatch repair acts as a barrier to recombination between diverge

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7

Huen, Shing-yan Michael. "A mechanistic study of lambdaphage-mediated recombination in E. coli." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B35321854.

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8

Knowles, Christopher. "Generation of mammalian cell culture systems for the rapid and efficient production of recombinant proteins." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231905.

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The overarching objective of this thesis was the development of an improved expression cell line for recombinant proteins, in which a transgene of interest can be inserted into a highly active gene locus using recombinase mediated cassette exchange. Random integration of transgenic DNA is a common route to achieve transgene expression. However, randomly integrated transgenes are susceptible to gene silencing over time, and do not show stable expression for extended periods in culture. Furthermore, every new cell clone generated requires regulatory approval. The improvement of expression strate

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9

Huen, Shing-yan Michael, and 禤承恩. "A mechanistic study of lambdaphage-mediated recombination in E. coli." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B35321854.

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10

Sinha, Manisha. "Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/412.

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Repairing a chromosomal DNA double strand break is essential for survival and maintenance of genomic integrity of a eukaryotic organism. The eukaryotic cell has therefore evolved intricate mechanisms to counteract all sorts of genomic insults in the context of chromatin structure. Modulating chromatin structure has been crucial and integral in regulating a number of conserved repair processes along with other fundamental genomic processes like replication and transcription. The work in this dissertation has focused on understanding the role of chromatin remodeling enzymes in the repair of a ch

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11

Ciciotte, Steven. "Characterization of CRE Recombinase Expression in Erythroid Tissues of Transgenic Mice." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/CiciotteS2005.pdf.

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12

Johansson, Carolina. "Mechanisms and DNA Specificity in Site-specific Recombination of Integron Cassettes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7429.

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13

Bennett, Brian Thomas. "Human Rad51: Regulation of Cellular Localization and Function in Response to DNA Damage: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/224.

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Repair of DNA double-strand breaks via homologous recombination is an essential pathway for vertebrate cell development and maintenance of genome integrity throughout the organism’s lifetime. The Rad51 enzyme provides the central catalytic function of homologous recombination while many other proteins are involved in regulation and assistance of Rad51 activity, including a group of five proteins referred to as Rad51 paralogs (Rad51B, Rad51C, Rad51D, Xrcc2, Xrcc3). At the start of my work, cellular studies of human Rad51 (HsRad51) had shown only that it forms distinct nuclear foci in response t

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14

Hardy, Matthew Philip 1974. "The molecular and functional characterization of soluble Ifnar-2." Monash University, Institute of Reproduction and Development, 2001. http://arrow.monash.edu.au/hdl/1959.1/8852.

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15

Bower, James Earl. "Concerted evolution of the rDNA ITS1 in the Anopheles punctulatus group." Access electronically, 2008. http://ro.uow.edu.au/theses/122.

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16

Kam, Ka-man. "Expression analysis of Hoxb5 in enteric neurons and generation of Tamoxifen inducible Cre mice for neuronal Hoxb5 signaling perturbation." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290574.

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17

Nadkarni, Aditi A. "Functional analysis of the Rad51d (E233G) breast cancer associated polymorphism and a pharmacogenetic evaluation of RAD51D status." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1222877984.

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Dissertation (Ph.D.)--University of Toledo, 2008.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 73-77, 93-95, 109-111, 145-172.

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18

Kam, Ka-man, and 甘嘉敏. "Expression analysis of Hoxb5 in enteric neurons and generation of Tamoxifen inducible Cre mice for neuronal Hoxb5 signalingperturbation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290574.

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19

Solimena, Michele, Anja Steffen, Maria Grazia Magro, et al. "Tamoxifen-Independent Recombination in the RIP-CreER Mouse." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-185663.

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Background The inducible Cre-lox system is a valuable tool to study gene function in a spatial and time restricted fashion in mouse models. This strategy relies on the limited background activity of the modified Cre recombinase (CreER) in the absence of its inducer, the competitive estrogen receptor ligand, tamoxifen. The RIP-CreER mouse (Tg (Ins2-cre/Esr1) 1Dam) is among the few available β-cell specific CreER mouse lines and thus it has been often used to manipulate gene expression in the insulin-producing cells of the endocrine pancreas. Principal Findings Here, we report the detection of

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20

Boyko, Oleksandr, and University of Lethbridge Faculty of Arts and Science. "The versatile role of homologous recombination in plant cell : repair of DNA damage, stress-directed genome evolution and foreign DNA integration." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/724.

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Homologous recombination represents a DNA repair pathway. Its role in a plant cell is not limited to double strand break repair. It also extends to genome evolution via rearranging of DNA sequences, and has an important application in foreign DNA integration in the plant genome. Our study demonstrated that effects exerted by stress on homologous recombination and genome stability are not restricted to the exposed generation. The progeny of plants exposed to stress exhibited elevated spontaneous homologous recombination, changes in DNA methylation and higher tolerance to stress. These heritable

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21

Solimena, Michele, Anja Steffen, Maria Grazia Magro, et al. "Tamoxifen-Independent Recombination in the RIP-CreER Mouse." PloS ONE, 2010. https://tud.qucosa.de/id/qucosa%3A29016.

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Background The inducible Cre-lox system is a valuable tool to study gene function in a spatial and time restricted fashion in mouse models. This strategy relies on the limited background activity of the modified Cre recombinase (CreER) in the absence of its inducer, the competitive estrogen receptor ligand, tamoxifen. The RIP-CreER mouse (Tg (Ins2-cre/Esr1) 1Dam) is among the few available β-cell specific CreER mouse lines and thus it has been often used to manipulate gene expression in the insulin-producing cells of the endocrine pancreas. Principal Findings Here, we report the detection of

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22

MATHOR, MONICA B. "Estudos da expressao genica mediante utilizacao de queratinocitos humanos normais transduzidos com o gene do hormonio de crescimento humano .Possivel utilizacao em terapia genica." reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10410.

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Made available in DSpace on 2014-10-09T12:38:22Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:05:27Z (GMT). No. of bitstreams: 1 05680.pdf: 8681194 bytes, checksum: c738dd10c1a17a2b018e74273b788729 (MD5)<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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23

Simms, Amy Nicole. "Examination of Neisseria gonorrhoeae opacity protein expression during experimental murine genital tract infection /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Simms2005.pdf.

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24

"New protein systems for homologous recombination-based DNA engineering in bacteria." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075070.

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Novel pairs of Bet/Exo recombineering proteins were identified in the beta-proteobacterium Laribacter hongkongensis (LHK) and in the SXT genetic element isolated from Vibrio cholerae. In this research, these new recombineering proteins were functionally characterized using a variety of in vivo and in vitro techniques. The SXT-Exo and LHK-Exo proteins were both found to be alkaline exonucleases, with activities similar to those of Lambda-Exo. Both the SXT-Bet/Exo and LHK-Bet/Exo protein pairs had dsDNA recombination activity within E. coli.<br>Recombineering is a powerful tool used to manipula

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25

Manjunath, G. P. "Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins." Thesis, 2009. http://hdl.handle.net/2005/1122.

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Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles in the repair of damaged DNA molecules, generation of genetic diversity and proper segregation of chromosomes. The genetic exchange is a highly orchestrated process that entails a plethora of control mechanisms and a large number of proteins, of which RecA and SSB are two proteins that have been chosen for further investigation(s) in the present study. In addition, we have als

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26

Gasior, Stephen L. "Assembly of recombination complexes in Saccharomyces cerevisiae /." 1999. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9951786.

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27

Lutz, Kerry. "Site-specific recombinases to manipulate the plastid genome." 2007. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16733.

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28

Anuradha, Valiya Kambrath. "Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism." Thesis, 2015. http://hdl.handle.net/1805/7942.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The Cre/loxP system is a tool for targeted recombination of DNA. For applying Cre recombinase-mediated genome modifications, there is a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor that allows Cre-expression only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven

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