Academic literature on the topic 'Genetic risk factor'

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Journal articles on the topic "Genetic risk factor"

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Koch, Linda. "Genetic T2DM risk factor found." Nature Reviews Endocrinology 10, no. 3 (2014): 128. http://dx.doi.org/10.1038/nrendo.2013.273.

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Sokolova, I. V., D. A. Mustafina, A. G. Sadertdinova, et al. "GENETIC RISK FACTOR FOR IDIOPATHIC SCOLIOSIS." International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований), no. 1 2023 (2023): 25–29. http://dx.doi.org/10.17513/mjpfi.13501.

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Reitsma, Pieter H. "Genetic Risk Factors of Thrombosis." Blood 114, no. 22 (2009): SCI—43—SCI—43. http://dx.doi.org/10.1182/blood.v114.22.sci-43.sci-43.

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Abstract Abstract SCI-43 Venous thrombosis is a common episodic disease with a steep age gradient. Interactions between various risk factors determine the development of the disease, and the proportion of variance attributable to genetic factors may be as high as 50-60%. There are six (moderately) strong genetic risk factors. First there are heterozygous deficiencies of the natural anticoagulants protein C, protein S, and antithrombin. These deficiency states are quite rare in the general population (in all races) and their genetic architecture is complex with hundreds of documented mutations.
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Ohishi, Mitsuru, Kenshi Fujii, Takazo Minamino, et al. "A potent genetic risk factor for restenosis." Nature Genetics 5, no. 4 (1993): 324–25. http://dx.doi.org/10.1038/ng1293-324.

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Senior, Kathryn. "New genetic risk factor for sporadic PD." Nature Reviews Neurology 5, no. 7 (2009): 354. http://dx.doi.org/10.1038/nrneurol.2009.79.

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Bertina, Rogier M. "Factor V Leiden and other coagulation factor mutations affecting thrombotic risk." Clinical Chemistry 43, no. 9 (1997): 1678–83. http://dx.doi.org/10.1093/clinchem/43.9.1678.

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Abstract Five genetic defects have been established as risk factors for venous thrombosis. Three are protein C, protein S, and antithrombin deficiencies, defects in the anticoagulant pathways of blood coagulation. Together they can be found in ∼15% of families with inherited thrombophilia. Their laboratory diagnosis is hampered by the large genetic heterogeneity of these defects. The other two genetic risk factors, resistance to activated protein C associated with the factor V Leiden mutation and increased prothrombin associated with the prothrombin 20210 A allele, are much more prevalent and
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Schwab, Manfred, Andreas Claas, and Larissa Savelyeva. "BRCA2: a genetic risk factor for breast cancer." Cancer Letters 175, no. 1 (2002): 1–8. http://dx.doi.org/10.1016/s0304-3835(01)00752-2.

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EVANS, JEFF. "Major Genetic Risk Factor Is Discovered for Parkinson's." Clinical Psychiatry News 38, no. 2 (2010): 33. http://dx.doi.org/10.1016/s0270-6644(10)70097-7.

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Medda, Emanuela, Serena Donati, Angela Spinelli, and Gian Carlo Di Renzo. "Genetic amniocentesis: a risk factor for preterm delivery?" European Journal of Obstetrics & Gynecology and Reproductive Biology 110, no. 2 (2003): 153–58. http://dx.doi.org/10.1016/s0301-2115(03)00106-4.

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Utermann, G. "Lipoprotein(a) ? A genetic risk factor for CHD." Fresenius' Journal of Analytical Chemistry 343, no. 1 (1992): 37. http://dx.doi.org/10.1007/bf00331978.

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Dissertations / Theses on the topic "Genetic risk factor"

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Ruth, Katherine Sarah. "Identification of genetic and non-genetic factors contributing to female reproductive ageing." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/19189.

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The aim of my work was to identify additional genetic and non-genetic factors influencing female reproductive ageing in humans. Although approximately 50% of population variation in age at menopause is due to genetics, less than 3% of variation had been accounted for by common genetic variants. Of non-genetic risk factors, only smoking had consistently been found to have a strong effect on age of menopause. In the wider context of female reproduction, our understanding of the role of genetics in determining sex hormone levels was limited. By combining the results of research in these different
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Chen, Hong [Verfasser]. "Plasminogen is a genetic risk factor of periodontitis / Hong Chen." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1196803110/34.

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Perdigão, Catarina. "The impact of the genetic risk factor BIN1 to Alzheimer’s disease development." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Quimica e Biológica António Xavier, 2021. http://hdl.handle.net/10362/132008.

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" Alzheimer’s disease (AD) was identified more than a century ago. Yet, there is still no cure and the mechanisms behind the most common form of AD (late-onset, LOAD) are still an open question. BIN1 was the second gene most frequently associated with LOAD. Bin1 depletion has been linked with AD earliest pathomechanisms: increased beta-amyloid (Aβ) accumulation, endosomal abnormalities, and synaptic defects. Sequencing of BIN1 genomic locus identified regulatory and coding variants of BIN1, indicating that Bin1 correct levels and function are essential for a healthy bra
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Caglayan, Safak [Verfasser]. "SORLA/SORL1 as genetic risk factor in Alzheimer disease / Safak Caglayan." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1043480935/34.

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Newsome, Jamie. "Resilience and Vulnerability in Adolescents at Risk for Delinquency: A Behavioral Genetic Study of Differential Response to Risk." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367937532.

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Mutize, Tinashe. "DNA methylation : a risk factor for type 2 diabetes mellitus." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2388.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2016.<br>The early detection of individuals who are at risk of developing type 2 diabetes mellitus (T2DM) would decrease the morbidity and mortality associated with this disease. DNA methylation, the most widely studied epigenetic mechanism, offers unique opportunities in this regard. Aberrant DNA methylation is associated with disease pathogenesis and is observed during the asymptomatic stage of disease. DNA methylation has therefore attracted increasing attention as a potential biomarker for identifying individual
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Kirin, Mirna. "Genetic analysis of retinal traits." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9619.

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Retina is a unique site in the human body where the microcirculation can be imaged directly and non-invasively, allowing us to study in vivo the structure and pathology of the human microcirculation. Retinal images can be quantitatively assessed with computerized imaging techniques, enabling us to measure several different quantitative traits derived from the retinal vasculature. Arterial and venular calibres are the most extensively studied traits of the retinal microvasculature and numerous epidemiological studies demonstrated promising associations with systemic and ocular diseases as well
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Mahlman, M. (Mari). "Genetic background and antenatal risk factors of bronchopulmonary dysplasia." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219530.

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Abstract Advances over the past few decades in ante- and neonatal care have led to the survival of a growing number of premature infants of extremely low gestational age. However, the occurrence of serious diseases, particularly those affecting the most immature infants, remains high. Bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, is one such disease. Our current understanding of the molecular pathogenesis of BPD is incomplete; consequently, there are few preventive and therapeutic options for BPD. Moreover, it is challenging to predict the risk of BPD. Previous
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Bayoumy, Nervana M. K. "Genetic analysis of plasma von Willebrand factor antigen levels as a risk factor for arterial and venous thrombosis." Thesis, University of Aberdeen, 2006. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU223247.

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We carried out the first genome-wide linkage analysis in British families for VWF levels. ABO and VWF loci were specifically examined. The results showed that VWF levels are highly heritable 42% ( P>0.000001) with age and C-reactive protein (CRP) the main covariates. The ABO locus was strongly associated with VWF levels ( P=2x10-18), but linkage was modest (LOD = 1.6). VWF gene marker showed no significant association or linkage with phenotype. Genome-wide linkage analysis, conditioned on age and ABO genotypes, revealed regions with potential linkage. Highlighted regions were on chromosomes 2
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Polasek, Ozren. "Investigating the role of human genome-wide heterozygosity as a health risk factor." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4799.

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Aim The aim of this study was to investigate the most commonly used approaches to measure individual genome-wide heterozygosity (IGWH) and to investigate whether IGWH can be considered as a health risk factor or a protective factor in humans. Methods This study was based on two samples from isolated communities of Croatian Adriatic islands, with a total of 1,930 adult examinees from Islands of Vis (N=986) and Korcula (N=944). Examinees were genotyped with a total of 302,662 single nucleotide polymorphisms. Heterozygosity was estimated using five commonly calculated methods. Results Correlation
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Books on the topic "Genetic risk factor"

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National Institute on Alcohol Abuse and Alcoholism (U.S.) and Editorial Experts Inc, eds. Alcoholism, an inherited disease. U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1985.

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Petrakis, Peter L. Alcoholism, and inherited disease. U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Alcohol Abuse and Alcoholism, 1985.

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David, Brusick, ed. Methods for genetic risk assessment. Lewis Publishers, 1994.

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Offit, Kenneth. Clinical cancer genetics: Risk counseling and management. Wiley-Liss, 1998.

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Kåre, Berg, ed. Genetic approaches of coronary heart disease and hypertension. Springer-Verlag, 1991.

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1946-, Choy Wai Nang, ed. Genetic toxicology and cancer risk assessment. Marcel Dekker, 2001.

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Symposium on Phenotypic Variation in Populations: Relevance to Risk Assessment (1986 Brookhaven National Laboratory). Phenotypic variation in populations: Relevance to risk assessment. Plenum Press, 1988.

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A, Levin Morris, and Strauss Harlee S, eds. Risk assessment in genetic engineering. McGraw-Hill, 1991.

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G, Evers-Kiebooms, ed. Genetic risk, risk perception, and decision making: Proceedings of a conference held July 28-29, 1986, Leuven, Belgium. A.R. Liss, 1987.

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Gould, Randi L. Cancer and genetics: Answering your patients' questions. PRR, 1997.

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Book chapters on the topic "Genetic risk factor"

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Waldinger, Marcel D. "Risks Factors in Premature Ejaculation: The Genetic Risk Factor." In Premature Ejaculation. Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2646-9_9.

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Astermark, Jan. "Genetic and Environmental Risk Factors for Factor VIII Inhibitor Development." In Textbook of Hemophilia. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118398258.ch6.

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Berg, Kåre. "Lp(a) Lipoprotein: A Monogenic Risk Factor for Cardiovascular Disease." In Genetic factors in coronary heart disease. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1130-0_18.

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Friedlander, Yechiel. "Familial Clustering of Coronary Heart Disease: A Review of its Significance and Role as a Risk Factor for the Disease." In Genetic factors in coronary heart disease. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1130-0_3.

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Yucel, Zeliha, and E. Berrin Yuksel. "The Genetics of Diabetic Neuropathy." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.39.

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Diabetic neuropathy, a common complication of diabetes mellitus (DM), involves nerve damage resulting from prolonged exposure to high blood sugar levels. Genetic factors play a crucial role in influencing susceptibility to this condition. Variations in genes related to nerve structure and function, inflammatory responses, and metabolic processes have been implicated in diabetic neuropathy. For instance, polymorphisms in the gene encoding protein kinase C beta (PKC-β) contribute to increased vulnerability by promoting oxidative stress and inflammation in nerve tissues. Similarly, genetic variat
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Aytulun, Sultan, and Musemma Alagoz Karabel. "Pneumocystis Pneumonia in Children." In Pediatric Chest Infection. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359463.13.

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Family history and genetic factors play a significant role in idiopathic pulmonary fibrosis. Mutations in genes related to surfactant production and telomere maintenance have been implicated. Environmental and occupational exposures to dust, metal, wood, and certain farming chemicals may increase the risk. Cigarette smoking is a well-established risk factor. Comorbid conditions such as gastroesophageal reflux disease (GERD), chronic viral infections, and other comorbidities may be associated with an increased risk of developing idiopathic pulmoary fibrosis. Idiopathic pulmonary fibrosisis asso
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Gonchar, Alexander, Maxim Ameliyanovich, Kristina Zhur, Irma Mosse, and Konstantin Mosse. "Molecular-Genetic Analysis of Genetic Predisposition to Myocardial Infarction and Comparison of Risk Factor Population Rates in Different Countries." In Radiobiology and Environmental Security. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1939-2_11.

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Poirier, Judes. "Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer’s disease." In Alzheimer: 100 Years and Beyond. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-37652-1_37.

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Zheng, Wei. "Genetic Polymorphisms in the Transforming Growth Factor-β Signaling Pathways and Breast Cancer Risk and Survival." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-492-0_11.

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Thiriet, Marc. "Genetic Risk Factors." In Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89315-0_7.

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Conference papers on the topic "Genetic risk factor"

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Kulkarni, S., X. Zhou, M. Nesline, et al. "Genetic Susceptibility as a Possible Risk Factor for Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-6067.

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MOTSINGER, ALISON A., BRIAN S. DONAHUE, NANCY J. BROWN, DAN M. RODEN, and MARYLYN D. RITCHIE. "RISK FACTOR INTERACTIONS AND GENETIC EFFECTS ASSOCIATED WITH POST-OPERATIVE ATRIAL FIBRILLATION." In Proceedings of the Pacific Symposium. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701626_0054.

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Dooper, Marten. "Nitric oxide synthase genetic variant is a risk factor for suicidal behaviour." In 35th ECNP Congress, edited by Christina Dalla. Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/c63a9364.

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Ferreira, Nancy, Darley Ferreira, and Thais Ferreira. "GENETIC EVALUATION OF MICROCALCIFICATIONS AS A PROGNOSTIC FACTOR." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2101.

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Introduction: Breast cancer is the most recurring type of cancer among women, with reduced mortality at an initial stage of lesion. From a radiological perspective, perceived microcalcifications may be associated with histological findings such as proliferative injuries with or without atypical features and ductal carcinoma in situ. Currently, percutaneous and vacuum biopsies allow for the correlation between anatomoradiological and identification of previous lesions and those that offer the risk of cancer. No biomarker has been established to predict the risk of cancer in women diagnosed with
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Surniyantoro, H. N. E., and N. R. Hidayati. "Preliminary study in genetic polymorphism of hOGG1 and risk factor for thyroid cancer in Indonesia." In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE AND SCHOOL ON PHYSICS IN MEDICINE AND BIOSYSTEM (ICSPMB): Physics Contribution in Medicine and Biomedical Applications. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0047941.

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Batai, Ken, Ebony Shah, and Rick A. Kittles. "Abstract B14: Population genetics analysis of prostate cancer GWAS SNPs to evaluate West African genetic ancestry as a risk factor." In Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December 6–9, 2013; Atlanta, GA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7755.disp13-b14.

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Allam, Ines, Aldjia Lamri, Sihem Oulacrouz, Mohamed Saidani, and Reda Djidjik. "P85 The IRF5 (rs729302) polymorphism is a genetic risk factor for systemic lupus erythematosus in Algerian patients." In 12th European Lupus Meeting. Lupus Foundation of America, 2020. http://dx.doi.org/10.1136/lupus-2020-eurolupus.130.

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Anghel, Lucretia, Dumitru Ursu, Simona Mitincu Caramfil, et al. "THE LINK BETWEEN LIPIDIC PROFILE, DEPRESSION AND CARDIOVASCULAR DISEASE." In The European Conference of Psychiatry and Mental Health "Galatia". Archiv Euromedica, 2023. http://dx.doi.org/10.35630/2022/12/psy.ro.17.

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The purpose of this study was to identify the connection between cardiovascular disease and depression taking lipid profile as a common risk factor in the occurrence of both pathologies. Materials and methods: 100 patients were examined for 3 months, admitted to the internal medicine department of St. Andrew's Emergency Hospital in Galati. Anamnesis was collected; electrocardiogram, objective examination and lipid profile were performed. The Hamilton scale (HDRS-17) was used to assess depression. Results: In patients with depression, an increased prevalence of dyslipidaemia and obesity was det
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Smyk, W., R. Hall, S. Weber, F. Grünhage, F. Lammert, and M. Krawczyk. "Common genetic variant c.711A>T in the hepatobiliary phospholipid translocator ABCB4 as risk factor for liver fibrosis." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402121.

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Finlen Copeland, Catherine, Francine L. Kelly, Laurie D. Snyder, and Scott M. Palmer. "Clinical And Genetic Predictors Of Pulmonary Aspergillus Infection, A Major Risk Factor For Bronchiolitis Obliterans Syndrome After Lung Transplantation." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2570.

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Reports on the topic "Genetic risk factor"

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Gelmann, Edward P. Genetic Risk Factor for Prostate Cancer. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada434784.

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Gelmann, Edward P. Genetic Risk Factor for Prostate Cancer. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada414867.

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Cao, Xianling, Xuanyou Zhou, Naixin Xu, Songchang Chang, and Chenming Xu. Association of IL-4 and IL-10 Polymorphisms with Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.4.0044.

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Review question / Objective: The aim of our systematic review and meta-analysis was to summarize the effects of IL-4 and IL-10 gene polymorphism and clarify their possible association with PTB. Condition being studied: World Health Organization (WHO) defines preterm birth (PTB) as babies born alive before 37 weeks of pregnancy are completed. The new estimates show that the prevalence of PTB during 2014 ranged from 8.7% to13.4% of all live births, about 15 million preterm babies born each year. Besides, PTB is the leading cause of death worldwide for children below 5 years of age. Babies born p
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Gelmann, Edward P. Genetics Risk Factor for Prostate Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada422932.

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Wongpiyabovorn, Jongkonnee, Nattiya Hirankarn, Yingyos Avihingsanon, Tewin Tencomnao, Yong Poovorawan, and Kriangsak Ruchusatsawat. The association between immunogenetics and genetic susceptibility of psoriasis in Thai population. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.27.

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Psoriasis is T-cell-mediated skin autoimmunity, required environmental triggers and genetic susceptibility factors to become manifested. Psoriasis is a chronic skin disease characterized by the abnormal hyperproliferation and differentiation of the epidermis, elongated and prominent blood vessels and a thick perivascular lymphocytic infiltrate. Vascular endothelial growth factor (VEGF) gene play important role in pathogenesis of various diseases with angiogenic basis such as breast cancer and autoimmune disease including psoriasis. Many studies analyzed the association of VEGF gene polymorphis
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Sarma, Aruna. Genetic and Hormonal Risk Factors for Cancer in African American Men. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada455088.

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Mack, Thomas M. Genetic Abnormalities in Breast Cancer Tumors and Relationships to Environmental and Genetic Risk Factors Using Twins. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada303152.

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Mack, Thomas M. Genetic Abnormalities in Breast Cancer Tumors and Relationships to environmental and Genetic Risk Factors Using Twins. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada393066.

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Sarma, Aruna V. Genetic and Hormonal Risk Factors for Prostate Cancer in African American Men. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada442683.

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Eshed-Williams, Leor, and Daniel Zilberman. Genetic and cellular networks regulating cell fate at the shoot apical meristem. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699862.bard.

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The shoot apical meristem establishes plant architecture by continuously producing new lateral organs such as leaves, axillary meristems and flowers throughout the plant life cycle. This unique capacity is achieved by a group of self-renewing pluripotent stem cells that give rise to founder cells, which can differentiate into multiple cell and tissue types in response to environmental and developmental cues. Cell fate specification at the shoot apical meristem is programmed primarily by transcription factors acting in a complex gene regulatory network. In this project we proposed to provide si
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