Relevant bibliographies by topics / Genetic Signal Transduction

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Genetic Signal Transduction'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Genetic Signal Transduction"

1

Swain, S. M., and N. E. Olszewski. "Genetic Analysis of Gibberellin Signal Transduction." Plant Physiology 112, no. 1 (1996): 11–17. http://dx.doi.org/10.1104/pp.112.1.11.

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Hagen, Gretchen. "Auxin signal transduction." Essays in Biochemistry 58 (September 15, 2015): 1–12. http://dx.doi.org/10.1042/bse0580001.

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The plant hormone auxin (indole-3-acetic acid, IAA) controls growth and developmental responses throughout the life of a plant. A combination of molecular, genetic and biochemical approaches has identified several key components involved in auxin signal transduction. Rapid auxin responses in the nucleus include transcriptional activation of auxin-regulated genes and degradation of transcriptional repressor proteins. The nuclear auxin receptor is an integral component of the protein degradation machinery. Although auxin signalling in the nucleus appears to be short and simple, recent studies indicate that there is a high degree of diversity and complexity, largely due to the existence of multigene families for each of the major molecular components. Current studies are attempting to identify interacting partners among these families, and to define the molecular mechanisms involved in the interactions. Future goals are to determine the levels of regulation of the key components of the transcriptional complex, to identify higher-order complexes and to integrate this pathway with other auxin signal transduction pathways, such as the pathway that is activated by auxin binding to a different receptor at the outer surface of the plasma membrane. In this case, auxin binding triggers a signal cascade that affects a number of rapid cytoplasmic responses. Details of this pathway are currently under investigation.
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Bonetta, Dario, and Peter McCourt. "Genetic analysis of ABA signal transduction pathways." Trends in Plant Science 3, no. 6 (1998): 231–35. http://dx.doi.org/10.1016/s1360-1385(98)01241-2.

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Jaeschke, Anja, and Roger J. Davis. "Chemical genetic analysis of signal transduction pathways." Expert Opinion on Therapeutic Targets 10, no. 4 (2006): 485–88. http://dx.doi.org/10.1517/14728222.10.4.485.

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MOCHIZUKI, Nobuyoshi. "Genetic Dissection of Plastid-Nuclear Signal Transduction." Nippon Nōgeikagaku Kaishi 71, no. 12 (1997): 1283–86. http://dx.doi.org/10.1271/nogeikagaku1924.71.1283.

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Lander, Eric S. "Signal transduction, cancer classification and genetic variation." Nature Genetics 23, S3 (1999): 29. http://dx.doi.org/10.1038/14256.

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Merlot, S., and J. Giraudat. "Genetic Analysis of Abscisic Acid Signal Transduction." Plant Physiology 114, no. 3 (1997): 751–57. http://dx.doi.org/10.1104/pp.114.3.751.

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Xing, Tim, and Mark Jordan. "Genetic engineering of plant signal transduction mechanisms." Plant Molecular Biology Reporter 18, no. 4 (2000): 309–18. http://dx.doi.org/10.1007/bf02825058.

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Padgett, Richard W., Cathy Savage та Pradeep Das. "Genetic and biochemical analysis of TGFβ signal transduction". Cytokine & Growth Factor Reviews 8, № 1 (1997): 1–9. http://dx.doi.org/10.1016/s1359-6101(96)00050-0.

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Takeuchi, Takuji, Takashi Kobunai, and Hiroaki Yamamoto. "Genetic Control of Signal Transduction in Mouse Melanocytes." Journal of Investigative Dermatology 92, s5 (1989): 239S—242S. http://dx.doi.org/10.1111/1523-1747.ep13075730.

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Dissertations / Theses on the topic "Genetic Signal Transduction"

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Allen, Trudie. "Genetic dissection of phytochrome A signal transduction in Arabidopsis." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29821.

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The signalling pathway of phytochrome A (phyA) is complex. This thesis describes analysis of mutants with altered phyA-mediated responses for enhancement of understanding concerning phyA signalling. A novel Arabidopsis mutant ( gil1) has been isolated which defines a point of interaction between phytochrome signalling and gravity signalling. This mutant, in contrast to wild-type (wt), displays gravitropic orientation of hypocotyls under red (R) and far-red (FR) light. The phytochrome mediated agravitropism, observed in wt under R and FR, is mediated by phyA and phytochrome B (phyB). Analysis of the gil1 mutant phenotypes suggests that this mutant is impaired in both phyA and phyB mediation of agravitropism. The T-DNA insertion, which is most likely responsible for the phenotype associated with gil1, was located to chromosome V, between two genes predicted by sequence analysis. Reduced expression of one of these genes (K19M22.14) occurs in gil1. Database analysis of the sequence of the K19M22.14 gene suggests no homology to any recognised genes. The phyA signalling mutant fhy3 has diminished responses to FR but amplified responses to R. The phenotypes associated with these amplified responses to R are here characterised for a number of different alleles in three ecotypes of Arabidopsis. Results suggest that fhy3 has some enhanced responses to R, and that these are more apparent in some alleles/ecotypes. Analysis of the fhy3phyB double mutant indicates that phyB is required for the enhancement of R responses through FHY3. Isolation and preliminary characterisation of mutants (sofs) which suppress some phenotypes of fhy1 is presented. These mutants may define new components of the phyA signalling pathway.
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Aboul-Soud, Mourad A. M. "Molecular, genetic and biochemical dissection of defence signal transduction in Arabidopsis." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/10688.

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Systemic acquired resistance (SAR) is a pivotal defence response to pathogen attack that results in a broad-spectrum long-lasting immunity throughout challenged plant tissues. However, little is known about the signal transduction events leading to the establishment of SAR in plants. To facilitate the identification of novel signal transduction components that are involved in the regulation of <i>p</i>athogenesis-<i>r</i>elated (<i>PR</i>) gene expression and the establishment of SAR, we have undertaken a functional genomic approach. Chapter III, presents and describes the results obtained during the identification and characterisation of one potential mutant. Thus, homozygous <i>Arabidopsis PR1a::luciferase</i> transgenic lines were transformed with activation tagging vector SKI15. Hence, we generated and screened 8000 T-DNA activation tagged lines for dominant gain-of-function mutants that exhibit constitutive luciferase expression. One putative mutant was identified that exhibited high luciferase activity; constitutive HR-like lesions in the absence of pathogen; and accelerated cell death; hence it was designated <i>p</i>otentiated <i>c</i>ell <i>d</i>eath 1 (<i>pcd1</i>). Moreover, histochemical and molecular analyses revealed that <i>pcd1</i> leaves accumulate high levels of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and constitutively express a battery of antioxidant and defence-related genes. Furthermore, biochemical analyses indicated that <i>pcd1</i> plants contain high constitutive levels of the signal compound salicylic acid (SA) and elevated peroxidase and constitutive mitogen activated protein kinase (MAPK) activities. Interestingly, <i>pcd1</i> plants exhibited heightened resistance against biotrophic bacterial and fungal pathogens. Importantly, epistasis analysis indicated that the HR-like lesions and H<sub>2</sub>O<sub>2 </sub>accumulation, characteristic to <i>pcd1</i> phenotype, are dependent on SA but independent on ethylene and jasmonic acid. The <i>pcd1</i> mutation was mapped to the lower arm of chromosome I.
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Braun, David Meyer. "Maize receptor-like protein kinase signal transduction and function /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841268.

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Kang, Shin Gene. "Molecular and genetic dissection of sugar signal transduction pathway in Arabidopsis thaliana." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092842961.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xxiv, 173 p.; also includes graphics (some col.). Includes bibliographical references (p. 155-173). Available online via OhioLINK's ETD Center
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Crampton, Michael Craig. "Physiological and genetic evidence for an OmpB signal transduction system in Erwinia chrysanthemi." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/21410.

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Bibliography: pages 132-155.<br>In order for bacteria to survive in their environment they must continuely sense signals such as, presence of host organisms, chemical concentrations, or variationsin other physiological parameters. Many bacteria sense their environment through the use of a two component regulatory systems. These systems usually employ the use of two different proteins, a sensor protein and its cognate response regulator. Some bacteria can survive fluctuations in medium osmolarity through the use of a two component signal transduction system. In Escherichia coli and Salmonella typhimurium this two component system includes the EnvZ sensor protein and its cognate response regulator, OmpR. The two genes that code for these proteins are envZ and ompR genes respectively. The two genes together form the ompB operonrespectively. This operon regulates the expression of two outer membrane proteins, OmpF and OmpC in response to medium osmolarity in E. coli.Erwinia chrysanthemi has been found to be sensitive to desication. Proliferation of soft rot, caused by this organism, has also been associated with irrigation. E.chrysanthemi has also been observed to respond to changes in medium osmolarity. Evidence of an ompB operon was thus sought. Outer membrane proteins were isolated using sodium lauroylsarcosine. Three major outer membrane proteins were isolated, namely Ompl (37.5 kd), Omp2 (35.5 kd) and Omp3 (34.5 kd). Increase in medium osmolarity resulted in an increase in expression of Omp3, while Ompl was suppressed. This lends support to the presence of an ompB like signal transduction system in E. chrysanthemi. Growth temperature was shown to have no effect on the expression of the major OMP. Similarly, culture growth phase had no effect on major OMP expression. However, two induced OMP were present from mid log phase onwards.
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Li, Xin. "Signal transduction pathways and their regulation of transcriptional factors during C. elegans development." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1228090565.

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Xiong, Liming. "A genetic study on environmental stress and abscisic acid signal transduction in Arabidopsis thaliana." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/284334.

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Many plant genes that are not expressed under normal growth conditions are activated in response to low temperature, drought, or salt stress. Plants must sense the stress they are under, then transmit the signal to the cellular machinery and activate stress-regulated genes. To help understand the signal events involved in the process, we used the firefly luciferase reporter gene driven by the stress-responsive RD29A promoter to screen for Arabidopsis mutants defective in stress signaling. In this study, the identification of several genetic loci is reported. Mutations in the FIERY1 locus resulted in increased gene expression under low temperature, drought, salt, and abscisic acid (ABA) treatments. FIERY1 thus underlies a connecting point of these diverse signaling pathways. FIERY1 encodes an inositol polyphosphate 1-phosphatase and is proposed to mediate the degradation of the second messenger inositol 1,4,5-trisphosphate. On the other hand, mutation in the SAD1 (s̲upersensitive to A̲BA and d̲rought 1) locus rendered the mutant plants more sensitive in gene expression, seed germination and seedling growth to ABA and salt/drought stress, but the response to cold was not changed. sad1 is also defective in drought-induced ABA biosynthesis and is impaired at the last step of ABA biosynthesis, i.e. the conversion of ABA aldehyde to ABA. SAD1 encodes an Sm-like U6 snRNP and is predicted to participate in mRNA processing. Two other loci defined in this study were found to encode enzymes in the ABA biosynthetic pathways. LOS5 encodes a molybdenum cofactor sulfurase and LOS6 encodes a zeaxanthin epoxidase. Mutations in these loci diminished osmotic stress-induced gene expression, suggesting that osmotic stress signaling does require ABA. Through studies with SAD1, LOS5 and LOS6 loci, a feedback regulatory loop was also identified. In this regulatory loop, ABA stimulates the expression of ABA biosynthetic genes, and this self-regulation may confer a rapid response to osmotic stress by speeding up ABA biosynthesis. These genetic, molecular, and biochemical studies provide many new insights into the signal transduction mechanisms in response to environmental stresses, and present successful examples of a molecular genetic approach to understand complex processes such as stress signal transduction.
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Anderson, David John. "Heterotrimeric G proteins in plant signal transduction : characterisation of tobacco and arabidopsis G ̊subunits /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16840.pdf.

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Brown, Gerald Francis. "Novel aspects of grass carp GHR gene regulation." Thesis, Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41897080.

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Knapp, Bettina, and Lars Kaderali. "Reconstruction of Cellular Signal Transduction Networks Using Perturbation Assays and Linear Programming." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127239.

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Perturbation experiments for example using RNA interference (RNAi) offer an attractive way to elucidate gene function in a high throughput fashion. The placement of hit genes in their functional context and the inference of underlying networks from such data, however, are challenging tasks. One of the problems in network inference is the exponential number of possible network topologies for a given number of genes. Here, we introduce a novel mathematical approach to address this question. We formulate network inference as a linear optimization problem, which can be solved efficiently even for large-scale systems. We use simulated data to evaluate our approach, and show improved performance in particular on larger networks over state-of-the art methods. We achieve increased sensitivity and specificity, as well as a significant reduction in computing time. Furthermore, we show superior performance on noisy data. We then apply our approach to study the intracellular signaling of human primary nave CD4+ T-cells, as well as ErbB signaling in trastuzumab resistant breast cancer cells. In both cases, our approach recovers known interactions and points to additional relevant processes. In ErbB signaling, our results predict an important role of negative and positive feedback in controlling the cell cycle progression.
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Books on the topic "Genetic Signal Transduction"

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Signal transduction mechanisms in cancer. R.G. Landes, 1995.

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Introduction to genomic signal processing with control. CRC Press, 2007.

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Moorman, Celine. Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans. s.n.], 2003.

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Tsai, Ming-Jer. Mechanism of steroid hormone regulation of gene transcription. R.G. Landes Co., 1994.

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Callahan, Sean M. The quorum-sensing regulon of Vibrio fischeri: Novel components of the autoinducer/LuxR regulatory circuit. Massachusetts Institute of Technology, 1999.

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Callahan, Sean M. The quorum-sensing regulon of Vibrio fischeri: Novel components of the autoinducer/LuxR regulatory circuit. Massachusetts Institute of Technology, 1999.

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Sen, Ganes C. Transcriptional regulation in the interferon system. Landes Bioscience, 1997.

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Imaginal discs: The genetic and cellular logic of pattern formation. Cambridge University Press, 2002.

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Jr, Lewis I. Held. Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation. Cambridge University Press, 2002.

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Rakesh, Kumar. Nuclear signaling pathways and targeting transcription in cancer. Humana Press, 2014.

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Book chapters on the topic "Genetic Signal Transduction"

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Edwards, Helena C., and Stephen E. Moss. "Functional and genetic analysis of annexin VI." In Signal Transduction Mechanisms. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2015-3_34.

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Parkinson, John S. "Genetic Approaches for Signaling Pathways and Proteins." In Two-Component Signal Transduction. ASM Press, 2014. http://dx.doi.org/10.1128/9781555818319.ch2.

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Macho, Alberto P., José S. Rufián, Javier Ruiz-Albert, and Carmen R. Beuzón. "Competitive Index: Mixed Infection-Based Virulence Assays for Genetic Analysis in Pseudomonas syringae-Plant Interactions." In Plant Signal Transduction. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3115-6_17.

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Khurana, Jitendra P., Akhilesh K. Tyagi, Paramjit Khurana, et al. "Molecular Genetic Analysis of Constitutively Photomorphogenic Mutants of Arabidopsis." In Signal Transduction in Plants. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1365-0_4.

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Okada, Kiyotaka, and Yoshiro Shimura. "Genetic analyses of signalling in flower development using Arabidopsis." In Signals and Signal Transduction Pathways in Plants. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0239-1_8.

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Raabe, T. "Genetic Analysis of Sevenless Tyrosine Kinase Signaling in Drosophila." In Protein Modules in Signal Transduction. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80481-6_13.

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Park, Eunjoo, and Tae-Houn Kim. "Chemical Genetic Approaches on ABA Signal Transduction." In Plant Chemical Biology. John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118742921.ch4.3.

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Detillieux, Karen A., Sarah K. Jimenez, David P. Sontag, Elissavet Kardami, Peter W. Nickerson, and Peter A. Cattini. "The Application of Genetic Mouse Models to Elucidate a Role for Fibroblast Growth Factor-2 in the Mammalian Cardiovascular System." In Signal Transduction and Cardiac Hypertrophy. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0347-7_27.

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Wilks, Andrew F., and Ailsa G. Harpur. "Somatic Cell Genetic Dissection of Interferon Signal Transduction Pathways." In Intracellular Signal Transduction: The JAK-STAT Pathway. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-22050-4_6.

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Bunnell, Stephen C., and Leslie J. Berg. "The Signal Transduction of Motion and Antigen Recognition: Factors Affecting T Cell Function and Differentiation." In Genetic Engineering. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-1739-3_4.

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Conference papers on the topic "Genetic Signal Transduction"

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Gyorffy, Balazs, Iwona Stelniec-Klotz, Christian Sigler, Attila Szijarto, Yu Qian, and Reinhold Schäfer. "Abstract PR06: Impact of RAL signal transduction on genetic program and growth control in KRAS- and BRAF-mutated colorectal cells and prognostic potential of pathway-responsive genes in cancer patients." In Abstracts: AACR Special Conference on RAS Oncogenes: From Biology to Therapy; February 24-27, 2014; Lake Buena Vista, FL. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1557-3125.rasonc14-pr06.

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LeDuc, Philip. "Linking Molecular to Cellular Biomechanics With Nano- and Micro-Technology." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43987.

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The link between mechanics and biochemistry has been implicated in a myriad of scientific and medical problem, from orthopedics and cardiovascular medicine, to cell motility and division, to signal transduction and gene expression. Most of these studies have been focused on organ-level issues, yet cellular and molecular level research has become essential over the last decade in this field thanks to the revolutionary developments in genetics, molecular biology, fabrication processes, and biotechnology. Developing the link between molecular and cellular biomechanics through subcellular studies can help uncover the complex interactions requisite for understanding higher order macroscopic behavior. Here, we will explore the link between molecular and cellular research through novel systems of nano- and micro-technology. In this, I will discuss novel technologies that we have developed and are utilizing, which include magnetic needles, three-dimension cell stretching systems, and microfluidics to examine the link between mechanics and biochemistry (including structural regulation through the cytoskeleton). By combining these novel approaches between engineering and biology, this multidisciplinary research can make a tremendous impact on the studies of human health and diseases through advances in fields such as proteomics, tissue engineering, and medical diagnostics.
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Najem, Joseph S., Graham J. Taylor, Charles P. Collier, and Stephen A. Sarles. "Synapse-Inspired Variable Conductance in Biomembranes: A Preliminary Study." In ASME 2017 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/smasis2017-3820.

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Memristors are solid-state devices that exhibit voltage-controlled conductance. This tunable functionality enables the implementation of biologically-inspired synaptic functions in solid-state neuromorphic computing systems. However, while memristors are meant to emulate an intricate signal transduction process performed by soft biomolecular structures, they are commonly constructed from silicon- or polymer-based materials. As a result, the volatility, intricate design, and high-energy resistance switching in memristive devices, usually, leads to energy consumption in memristors that is several orders of magnitude higher than in natural synapses. Additionally, solid-state memristors fail to achieve the coupled dynamics and selectivity of synaptic ion exchange that are believed to be necessary for initiating both short- and long-term potentiation (STP and LTP) in neural synapses, as well as paired-pulse facilitation (PPF) in the presynaptic terminal. LTP is a phenomenon mostly responsible for driving synaptic learning and memory, features that enable signal transduction between neurons to be history-dependent and adaptable. In contrast, current memristive devices rely on engineered external programming parameters to imitate LTP. Because of these fundamental differences, we believe a biomolecular approach offers untapped potential for constructing synapse-like systems. Here, we report on a synthetic biomembrane system with biomolecule-regulated (alamethicin) variable ion conductance that emulates vital operational principals of biological synapse. The proposed system consists of a synthetic droplet interface bilayer (DIB) assembled at the conjoining interface of two monolayer-encased aqueous droplets in oil. The droplets contain voltage-activated alamethicin (Alm) peptides, capable of creating conductive pathways for ion transport through the impermeable lipid membrane. The insertion of the peptides and formation of transmembrane ion channels is achieved at externally applied potentials higher than ∼70 m V. Just like in biological synapses, where the incorporation of additional receptors is responsible for changing the synaptic weight (i.e. conductance), we demonstrate that the weight of our synaptic mimic may be changed by controlling the number of alamethicin ion channels created in a synthetic lipid membrane. More alamethicin peptides are incorporated by increasing the post-threshold external potential, thus leading to higher conductance levels for ion transport. The current-voltage responses of the alamethicin-based synapse also exhibit significant “pinched” hysteresis — a characteristic of memristors that is fundamental to mimicking synapse plasticity. We demonstrate the system’s capability of exhibiting STP/PPF behaviors in response to high-frequency 50 ms, 150 mV voltage pulses. We also present and discuss an analytical model for an alamethicin-based memristor, classifying that later as a “generic memristor”.
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Reports on the topic "Genetic Signal Transduction"

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Hoffmann, F. M. A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors for TGF-B-Related Factors. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada306742.

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Hoffman, F. M. A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors for TGF-B-Related Factors. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada360941.

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