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Relevant bibliographies by topics / Genetic Signal Transduction / Dissertations / Theses

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Dissertations / Theses on the topic 'Genetic Signal Transduction'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Allen, Trudie. "Genetic dissection of phytochrome A signal transduction in Arabidopsis." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29821.

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The signalling pathway of phytochrome A (phyA) is complex. This thesis describes analysis of mutants with altered phyA-mediated responses for enhancement of understanding concerning phyA signalling. A novel Arabidopsis mutant ( gil1) has been isolated which defines a point of interaction between phytochrome signalling and gravity signalling. This mutant, in contrast to wild-type (wt), displays gravitropic orientation of hypocotyls under red (R) and far-red (FR) light. The phytochrome mediated agravitropism, observed in wt under R and FR, is mediated by phyA and phytochrome B (phyB). Analysis o

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2

Aboul-Soud, Mourad A. M. "Molecular, genetic and biochemical dissection of defence signal transduction in Arabidopsis." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/10688.

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Systemic acquired resistance (SAR) is a pivotal defence response to pathogen attack that results in a broad-spectrum long-lasting immunity throughout challenged plant tissues. However, little is known about the signal transduction events leading to the establishment of SAR in plants. To facilitate the identification of novel signal transduction components that are involved in the regulation of <i>p</i>athogenesis-<i>r</i>elated (<i>PR</i>) gene expression and the establishment of SAR, we have undertaken a functional genomic approach. Chapter III, presents and describes the results obtained dur

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3

Braun, David Meyer. "Maize receptor-like protein kinase signal transduction and function /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841268.

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4

Kang, Shin Gene. "Molecular and genetic dissection of sugar signal transduction pathway in Arabidopsis thaliana." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092842961.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xxiv, 173 p.; also includes graphics (some col.). Includes bibliographical references (p. 155-173). Available online via OhioLINK's ETD Center

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5

Crampton, Michael Craig. "Physiological and genetic evidence for an OmpB signal transduction system in Erwinia chrysanthemi." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/21410.

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Bibliography: pages 132-155.<br>In order for bacteria to survive in their environment they must continuely sense signals such as, presence of host organisms, chemical concentrations, or variationsin other physiological parameters. Many bacteria sense their environment through the use of a two component regulatory systems. These systems usually employ the use of two different proteins, a sensor protein and its cognate response regulator. Some bacteria can survive fluctuations in medium osmolarity through the use of a two component signal transduction system. In Escherichia coli and Salmonella t

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6

Li, Xin. "Signal transduction pathways and their regulation of transcriptional factors during C. elegans development." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1228090565.

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7

Xiong, Liming. "A genetic study on environmental stress and abscisic acid signal transduction in Arabidopsis thaliana." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/284334.

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Many plant genes that are not expressed under normal growth conditions are activated in response to low temperature, drought, or salt stress. Plants must sense the stress they are under, then transmit the signal to the cellular machinery and activate stress-regulated genes. To help understand the signal events involved in the process, we used the firefly luciferase reporter gene driven by the stress-responsive RD29A promoter to screen for Arabidopsis mutants defective in stress signaling. In this study, the identification of several genetic loci is reported. Mutations in the FIERY1 locus resul

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8

Anderson, David John. "Heterotrimeric G proteins in plant signal transduction : characterisation of tobacco and arabidopsis G ̊subunits /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16840.pdf.

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9

Brown, Gerald Francis. "Novel aspects of grass carp GHR gene regulation." Thesis, Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41897080.

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10

Knapp, Bettina, and Lars Kaderali. "Reconstruction of Cellular Signal Transduction Networks Using Perturbation Assays and Linear Programming." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127239.

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Perturbation experiments for example using RNA interference (RNAi) offer an attractive way to elucidate gene function in a high throughput fashion. The placement of hit genes in their functional context and the inference of underlying networks from such data, however, are challenging tasks. One of the problems in network inference is the exponential number of possible network topologies for a given number of genes. Here, we introduce a novel mathematical approach to address this question. We formulate network inference as a linear optimization problem, which can be solved efficiently even for

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11

Knapp, Bettina, and Lars Kaderali. "Reconstruction of Cellular Signal Transduction Networks Using Perturbation Assays and Linear Programming." Public Library of Science, 2013. https://tud.qucosa.de/id/qucosa%3A27289.

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Perturbation experiments for example using RNA interference (RNAi) offer an attractive way to elucidate gene function in a high throughput fashion. The placement of hit genes in their functional context and the inference of underlying networks from such data, however, are challenging tasks. One of the problems in network inference is the exponential number of possible network topologies for a given number of genes. Here, we introduce a novel mathematical approach to address this question. We formulate network inference as a linear optimization problem, which can be solved efficiently even for

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12

Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.

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13

Yang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.

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14

Swaroop, Navin V. "Nuclear factor-[kappa] B signal transduction development of a novel regulatory strategy /." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1598.

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Thesis (M.S.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 70 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 63-68).

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15

Heusner, Carrie L. "Genetic analysis of striatal glutamate-dopamine interactions /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9212.

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16

Tam, Chun-yat, and 譚俊逸. "Genetic interaction between Patched1 and Sox10 in enteric nervous system development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/211149.

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The enteric nervous system (ENS) is derived from neural crest cells (NCCs). Once these NCCs reach the foregut, they are recognized as enteric NCCs(ENCCs) which subsequently colonize the gastrointestinal track. The proliferation, migration and neuronal versusglial differentiation of ENCCs are tightly controlled by multiple signaling pathways and transcription factors. Impaired ENS development may result in various human congenital disorders such as Hirschsprung disease(HSCR). Hedgehog (Hh) signaling is a key element in ENS development. Patched-1 (Ptch1) is a negatively regulated receptor for

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17

Wang, Boshi, and 王博石. "The roles of Irx3/5 genes and hedgehog signaling in mammalian cochlear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208555.

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18

Morreale, Eric. "A Genetic Screen for Modulators of the Notch Pathway in Drosophila Melanogaster Identifies Not1 as a Positive Regulator of Notch Signaling." Thesis, Boston College, 2009. http://hdl.handle.net/2345/1343.

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Thesis advisor: Marc A.T. Muskavitch<br>The Notch pathway is an evolutionarily conserved mechanism of intercellular signaling that plays a central role in the development of metazoans. Here I summarize two genetic screens that utilize a rough eye phenotype created by Delta overexpression in the Drosophila eye to identify modulators of Notch pathway signaling activity. Among the many "hits" obtained from both screens, I have mapped to the Not1 gene a single complementation group that exhibits strong genetic interactions with Notch pathway mutants. NOT1 is a component of the CCR4-NOT complex, a

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19

Samanta, Priyankar. "Gene Regulation in Biofilms." Thesis, North Dakota State University, 2011. https://hdl.handle.net/10365/29330.

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Sessile bacterial communities which form on the solid surface or solid-liquid interface are known as biofilms. Both single species and multispecies biofilms are characterized by an extracellular matrix of polymeric substances which gives them several hundred times more antibiotic resistances than a planktonic bacterial culture. Though bacteria are the most common causative agent of various diseases, because of the high antibiotic resistance, biofilms cause complications of various diseases like cystic fibrosis, prosthetic valve endocarditis, chronic pulmonary diseases, catheter-associate

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20

Hoyos, Rendón Mary Elizabeth. "From signal to gene induction : molecular aspects of bacterial HR /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924888.

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21

Pierce, Deanne Lynn. "Genetic and biochemical analysis of a signal transduction pathway coordinating polar development and cell division in Caulobacter crescentus." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3283108.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5726. Adviser: Yves V. Brun. Title from dissertation home page (viewed May 12, 2008).

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22

Van, Dyk Dewald 1975. "Genetic analysis of a signal transduction pathway : the regulation of invasive growth and starch degradation in Saccharomyces cerevisiae." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/49972.

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Dissertation (PhD)--University of Stellenbosch, 2004.<br>ENGLISH ABSTRACT: Cells of the yeast Saccharomyces cerevisiae are able to change their morphological appearance in response to a variety of extracellular and intracellular signals. The processes involved in morphogenesis are well characterised in this organism, but the exact mechanism by which information emanating from the environment is integrated into the regulation of the actin cytoskeleton and the yeast cell cycle, is still not clearly understood. Considerable progress has, however, been made. The processes are investigated o

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23

Dacher, Mariko. "Genetic analysis of Leishmania signal transduction through the establishment and application of a novel conditional knock-out system." Paris 7, 2012. http://www.theses.fr/2012PA077121.

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La phosphorylation des protéines joue un rôle important dans de nombreux processus fondamentaux chez le parasite Leishmania, et les mitogen-activated protein kinases (MAPKs) sont susceptibles d'intervenir dans les cascades de signalisation impliquées notamment dans le développement des différents stades du parasite et dans ses propriétés de virulence. Mon travail de thèse a consisté principalement à étudier les mécanismes de signalisation impliqués dans la virulence de Leishmania et ceci dans le cadre de trois projets principaux. Dans le 1er projet j'ai étudié le rôle de la MPK4 de L major en

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24

Jacobs, Michael A. "Identification and characterization of a chloroplast-encoded His-Asp signal transduction protein in the toxic stramenopile Heterosigma akashiwo /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5250.

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25

Cheung, Yuk Kam. "The development of alternative methods to introduce the Ca2+-sensitive bioluminescent complex, aequorin, into zebrafish embryos /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202005%20CHEUNG.

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26

Ma, Yam-man Richard, and 馬蔭民. "The mitogen-activated protein kinase pathway regulates the subcellularlocalization and function of FOXM1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29305378.

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27

Wang, Xue, and 王雪. "Molecular and cellular consequences of Indian hedgehog mutations causing brachydactylies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/208549.

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28

LeBaron, Matthew J. "Technologies for genome-wide identification of Stat5 regulated genes." Retrieve the information from the LRC's website, 2003. http://www.lrc.usuhs.mil/dissertations/pdf/LeBaron2003.pdf.

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29

Gardner, Stewart G. "Genetic analysis of conserved residues in PhoU of Escherichia coli." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd934.pdf.

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30

Au, Yuen-kwan, and 區箢筠. "Study of PACAP and NGF signal transduction pathways in regulating serpin gene expression in PC12 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30140031.

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31

Law, Kit-fong Stephanie, and 羅潔芳. "The molecular consequences of Indian hedgehog mutations in distal digit patterning." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31353253.

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32

Zhou, Zhenzhen. "Study of light dependent Arabidopsis phytochrome A signal transduction through FHY1 and its downstream gene expression regulation." Diss., Online access via UMI:, 2009.

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33

Grant, John J. "A genetic dissection of signal transduction pathways underlying the oxidative burst, cognate redox signalling, and establishment of systemic acquired resistance." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/14932.

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Recognition of avirulent microbial pathogens activates an oxidative burst, leading to the accumulation of reactive oxygen intermediates (ROIs), which are thought to integrate a diverse set of defence mechanisms resulting in the establishment of plant disease resistance. Two contrasting experimental strategies were devised to dissect genetic mechanisms governing these signal transduction pathways. Firstly, a novel transgenic <i>Arabidopsis</i> line containing a <i>gstl::luc</i> transgene was developed and employed to report the temporal and spatial dynamics of ROI accumulation and cognate redox

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34

Cheng, Wai-sheung, and 鄭偉嫦. "PTEN-PKB in endometriosis and related malignant transformation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45009910.

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35

Haffner, Christopher W. "Examination of Stat6-regulated genes and their contribution to the development of a lympho-proliferative disorder." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1380101.

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Stat6 is a protein that activates the transcription of IL-4-stimulated genes. Amino acids critical for Stat6 function were examined in a mutational analysis of the Src homology (SH2) domain of the Stat6 protein. One mutation, substitution of two Alanines for Valine and Threonine in the N-terminal portion of the SH2 domain, produced a constitutively active form of the molecule that did not require IL-4 for activation. This mutant was named Stat6VT. Mice expressing Stat6VT in lymphocytes were generated, and it was found that approximately 10% of the population of Stat6VT mice, a lympho-prolifera

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36

Poon, Hiu-ching. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 enteric gene in the enteric neural crest cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841604.

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37

Madsen, Ralitsa Radostinova. "Investigation of genetic PIK3CA activation in genome-edited human pluripotent stem cells." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289436.

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Mosaic, activating mutations in PIK3CA, the gene encoding the catalytic p110α subunit of class IA phosphatidylinositol 3-kinase (PI3K), are the cause of rare, developmental growth disorders collectively known as PIK3CA-Related Overgrowth Spectrum (PROS). Given the pressing need for targeted therapy and evidence for tissue- and cell lineage-specific distribution of PIK3CA mutations in PROS, developmental models of this disease will be a key asset for preclinical drug testing and for a better understanding of PIK3CA activation in development. This PhD project addressed the lack of human, develop

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38

Chan, Richard Muller William J. "In vivo structure-function studies of the ErbB2 receptor tyrosine kinase /." *McMaster only, 2004.

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39

Ng, Ming-him, and 吳明謙. "Ras signalling pathway and MLL-rearranged leukaemias." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37238656.

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40

Poon, Hiu-ching, and 潘曉澄. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 entericgene in the enteric neural crest cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841604.

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41

Hung, Chun-hin, and 孔進軒. "Effect of novel Chinese specific presenilin-1 V97L mutation on intracellular calcium homeostasis in human neuroblastoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193533.

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Presenilin-1 (PS1) mutations caused by the PSEN1 gene mutations are the major cause of early onset familial Alzheimer’s disease (EOFAD). Two Chinesespecific EOFAD related PS1 mutations, V97L and A136G, have been found. Studies suggested that V97L mutation lead to the overexpression of Aβ42 and tau hyperphosphorylation, which are the major hallmarks of Alzheimer’s disease (AD), while properties of A136G were unclear. Since calcium dysregulation was suggested to play an important role in AD, the research project investigated if V97L and A136G mutations also lead to altered endoplasmic reticulum

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42

Koivumäki, J. (Jussi). "Regulation of excitation-contraction coupling in cardiac myocytes:insights from mathematical modelling." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514293047.

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Abstract Background – The heart cell is a prime example of a system, in which numerous interconnected regulatory mechanisms affect the dynamic balance of cellular function. The function of the system emerges from the interactions of its components rather than from their individual properties. Thus, it is a challenging task to understand the causal relations within such a system, based on the analysis of experimental results. Facing this complexity, the systems biological approach has gained interest during recent years, since with using it we can make an effort to observe, quantitatively and s

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43

Botham, Crystal Marie. "Molecular and genetic dissection of host pathways disrupted by Helicobacter pylori's virulence factor, cytotoxin associated gene A /." view abstract or download file of text, 2007. http://proquest.umi.com/pqdweb?did=1417800931&sid=1&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2007.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 60-66). Also available for download via the World Wide Web; free to University of Oregon users.

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44

陳展豪 and Chin-ho Chan. "Signalling pathways of M918T RET mutant in multiple endocrine neoplasia type 2B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34603244.

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45

Ahn, Jeong H. Lee Myeongwoo. "The functional analysis of NPXY motif in [beta] integrin in vivo." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5275.

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46

Zimmerer, Jason Michael. "Interferon-alpha immunotherapy of melanoma signal transduction, gene transcription, and the role of suppressor of cytokine signaling proteins in immune cells /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1173305217.

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47

Xiong, Hao. "Constrained expectation-maximization (EM), dynamic analysis, linear quadratic tracking, and nonlinear constrained expectation-maximation (EM) for the analysis of genetic regulatory networks and signal transduction networks." Thesis, [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2332.

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48

Pineda, Victor Viray. "A genetic and pharmacological dissection of synaptic plasticity in the hippocampus /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6290.

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陳俊峯 and Chun-fung Anthony Chan. "Dysregulation of nuclear factor-kappa B (NF-KB) signaling pathway in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31227156.

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Du, Yang, and 杜洋. "The role of inhibitors of differentiation (Id) and BMP/Smad signaling pathway in retinal cell development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43223783.

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