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Journal articles on the topic 'Genetically modified animals'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

O'Connor, Kevin W. "Patents for genetically modified animals." Journal of Animal Science 71, suppl_3 (1993): 34–40. http://dx.doi.org/10.2527/1993.71suppl_334x.

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2

Thompson, Paul B. "Genetically modified animals: ethical issues." Journal of Animal Science 71, suppl_3 (1993): 51–56. http://dx.doi.org/10.2527/1993.71suppl_351x.

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3

Yeung, Rae S. M., Josef Penninger, and Tak W. Mak. "Genetically modified animals and immunodeficiency." Current Opinion in Immunology 5, no. 4 (1993): 585–94. http://dx.doi.org/10.1016/0952-7915(93)90042-q.

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4

Rose, Margaret. "Welfare Phenotyping of Genetically-Modified Mice." Alternatives to Laboratory Animals 37, no. 2 (2009): 181–86. http://dx.doi.org/10.1177/026119290903700206.

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Technologies that enable the targeted manipulation of the genome have created new opportunities to study the role and interplay of specific genes in both the regulation and function of physiological and behavioural processes and in the development of pathological conditions. Despite the potential benefits, there are ethical issues in relation to the application of these technologies, some of which relate to the impact on the welfare of the animals involved. Matters of concern include the methods involved in the derivation and production of genetically-modified (GM) animals and resulting phenot

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5

Tiesnamurti, Bess, Sri Muharsini, and M. I. Shiddieqy. "Regulation on Genetically Modified Animals: Proposed and Its Possible Application in Indonesia." Indonesian Bulletin of Animal and Veterinary Sciences 31, no. 4 (2021): 199. http://dx.doi.org/10.14334/wartazoa.v31i4.2972.

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The government is responsible for fulfil the needs of safe, healthy and halal food for all its people in a sustainable manner. The world population will increase from 7 to 9 billion people in 2050. While the availability of land may not increase in the future, it may even not be used for agriculture. Scientists are trying to overcome this problem by creating technologies that can increase livestock productivity, one of which is through a genetically modified process. Genetically modified animals are animals that have been genetically modified for many purposes including yields and disease resi

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6

Price, Catherine. "The Online Genetically Modified Food Debate: Sociotechnical Imaginaries and Genetically Modified Animals." Networking Knowledge: Journal of the MeCCSA Postgraduate Network 14, no. 2 (2021): 24–40. http://dx.doi.org/10.31165/nk.2021.142.641.

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The aim of this article is to investigate the sociotechnical imaginaries present in UK online news articles and below the line comments in connection with genetically modified animals. This article attempts to provide an answer through a qualitative study using discourse analysis. The findings reveal how sociotechnical imaginaries present in news articles depict genetically modified animals as ‘other’ in comparison to those bred through selective breeding. In the below the line comments, a key feature is of monstrosity. Here, the sociotechnical imaginaries draw on the concept of ‘other’ along

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7

J. Frewer, Lynn, David Coles, Louis-Marie Houdebine, and Gijs A. Kleter. "Attitudes towards genetically modified animals in food production." British Food Journal 116, no. 8 (2014): 1291–313. http://dx.doi.org/10.1108/bfj-08-2013-0211.

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Purpose – Food products developed using genetically modified (GM) animals may soon be introduced in Europe and beyond. Their successful commercialisation depends on consumer acceptance, and so it is timely to review the existing literature in this respect. The paper aims to discuss these issues. Design/methodology/approach – A systematic review identified 42 English language peer reviewed papers assessing public opinion of GM animals associated with food production. Thematic analysis was applied to the results to identify and explain consumer attitudes. Findings – Publication peaked in 2004, a

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8

Larue, Lionel, and Friedrich Beermann. "Cutaneous melanoma in genetically modified animals." Pigment Cell Research 20, no. 6 (2007): 485–97. http://dx.doi.org/10.1111/j.1600-0749.2007.00411.x.

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9

HACKETT, Perry Bradbury. "Regulatory issues for genetically modified animals." Frontiers of Agricultural Science and Engineering 7, no. 2 (2020): 188. http://dx.doi.org/10.15302/j-fase-2019307.

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10

Dennis, M. B. "Welfare Issues of Genetically Modified Animals." ILAR Journal 43, no. 2 (2002): 100–109. http://dx.doi.org/10.1093/ilar.43.2.100.

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11

Bruggemann, Edward P. "Environmental safety issues for genetically modified animals." Journal of Animal Science 71, suppl_3 (1993): 47–50. http://dx.doi.org/10.2527/1993.71suppl_347x.

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12

Engle, Sandra. "Genetically modified animals models and safety testing." Journal of Pharmacological and Toxicological Methods 60, no. 2 (2009): 260. http://dx.doi.org/10.1016/j.vascn.2009.04.008.

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13

Hubrecht, R. "Genetically Modified Animals, Welfare and UK Legislation." Animal Welfare 4, no. 3 (1995): 163–70. http://dx.doi.org/10.1017/s0962728600017772.

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IntroductionThe first experiments in genetic engineering took place in the late sixties and early seventies, but animal transgenics (the insertion of DNA into the genome of an animal) really came of age with the production of mice whose genetic sequences contained a gene for human growth hormone (Palmiter et al 1982). Since then there has been a dramatic increase in the quantity of research into genetic modification, using various techniques. This has been largely driven by the potential medical and financial benefits of being able to modify animal and plant genomes (Carver et al 1993; Smith 1

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14

Fajardo, Carlos, Marta Macedo, Tonka Buha, Marcos De Donato, Benjamin Costas, and Juan Miguel Mancera. "Genetically Modified Animal-Derived Products: From Regulations to Applications." Animals 15, no. 11 (2025): 1570. https://doi.org/10.3390/ani15111570.

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Biotechnological advances applied to the generation of genetically modified (GM) animals have shown the potential to develop innovative solutions for different challenges in key areas such as agriculture and human medicine. Despite its enormous potential, the deployment of genetic modification in animals, and its subsequent commercialization, does not meet the same public acceptance as GM plant-derived products, which are currently widely adopted around the world. In this review, we highlight the main examples of GM and gene-edited animal-derived products already approved by the FDA and discus

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15

Dobrowolski, Peter, Thorsten Buch, and Stefan Nagel-Riedasch. "Nomenclature for standardized designation of diploid genotypes in genetically modified laboratory animals." Laboratory Animals 57, no. 4 (2023): 371–80. http://dx.doi.org/10.1177/00236772231175727.

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Information about the diploid genotype of a gene-modified or mutant laboratory animal is essential for breeding and experimental planning. It is also required for the exchange of animals between different research groups or for communication with professional genotyping service providers. While there are detailed, standardized rules for creating an allele name of a genome modification or mutation, the notation of the diploid genotype after biopsy and genotyping has not been standardized yet. Therefore, a uniform, generally understandable nomenclature for the diploid genotype of gene-modified l

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16

Carstairs, Alice, Julia Marshall, and Paul Genever. "Knockout tissue models: Targeted gene disruption in three dimensions." Biochemist 36, no. 3 (2014): 14–18. http://dx.doi.org/10.1042/bio03603014.

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The use of animal studies in scientific research is increasing, mostly attributed to the rising requirement for genetically modified animals. In 2012, 4.11 million animal procedures were conducted within the UK, the majority of which involved genetically modified animals; a first since records began. Although animal models bring clear scientific insight, they have their limitations and alternative research methods are actively sought. The development of new targeted gene disruption technologies, such as transcription activatorlike effector nucleases (TALENs) and clustered regularly interspaced

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17

Clauss, Sebastian, Christina Bleyer, Dominik Schüttler, et al. "Animal models of arrhythmia: classic electrophysiology to genetically modified large animals." Nature Reviews Cardiology 16, no. 8 (2019): 457–75. http://dx.doi.org/10.1038/s41569-019-0179-0.

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18

Deykin, Alexey V., Olesya V. Shcheblykina, Elena E. Povetka, et al. "Genetically modified animals for use in biopharmacology: from research to production." Research Results in Pharmacology 7, no. (4) (2021): 11–27. https://doi.org/10.3897/rrpharmacology.7.76685.

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Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented. Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. The necessity of improving the technology of development transgenic rabbit producers and creating a platform solution for the production of biological products is substantiated. The advantages of using TrB for the production of

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19

Kumar, Ashok, and Satish Kumar Sharma. "Genetically Modified Animals in Pharmaceutical and Food Chains." Advances in Pharmacology and Pharmacy 8, no. 4 (2020): 72–80. http://dx.doi.org/10.13189/app.2020.080403.

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20

Friedlander, Gérard, Isabelle Runembert, François Vrtovsnik, and Fabiola Terzi. "Renal Tubular Cells Cultured from Genetically Modified Animals." Nephron Experimental Nephrology 7, no. 5-6 (1999): 407–12. http://dx.doi.org/10.1159/000020638.

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21

Rudolph, Uwe, and Hanns Möhler. "Genetically modified animals in pharmacological research: future trends." European Journal of Pharmacology 375, no. 1-3 (1999): 327–37. http://dx.doi.org/10.1016/s0014-2999(99)00195-8.

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22

Hryhorowicz, Magdalena, Daniel Lipiński, Szymon Hryhorowicz, Agnieszka Nowak-Terpiłowska, Natalia Ryczek, and Joanna Zeyland. "Application of Genetically Engineered Pigs in Biomedical Research." Genes 11, no. 6 (2020): 670. http://dx.doi.org/10.3390/genes11060670.

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Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic animal species is not only aimed towards accelerating traditional breeding programs and improving animal health and the quality of animal products for consumption but can also be used in biomedicine. Animal studies are conducted to develop models used in gene function and regulation research and the gene

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23

Gomez-Otamendi, Jaaasai. "Bioethics and Genetically Modified Foods." Mexican Bioethics Review ICSA 1, no. 1 (2019): 1–7. http://dx.doi.org/10.29057/mbr.v1i1.4852.

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Currently, the genetic modification of plants, animals and other organisms has intensified and has allowed the development of increasingly advanced methods. The creation of transgenic foods, their use and distribution have generated various positions, since there is no certainty about their effects on human health or the environment. The objective of bioethics is then to question what is the best environment for the development of new food technologies and balances the ideas of the sectors that support or reject the production and use of genetically modified organisms, and in this way promotes

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24

Akram, Muhammad Zeeshan, Sema Yaman, Hassan Jalal, Sibel Canoğulları Doğan, Sana Shahid, and Basit Shaukat Ali. "Effects of Feeding Genetically Modified Crops to Domestic Animals: A Review." Turkish Journal of Agriculture - Food Science and Technology 7, sp1 (2019): 110. http://dx.doi.org/10.24925/turjaf.v7isp1.110-118.2773.

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Genetically modified (GM) crops are being planted at large scale worldwide. In most of the countries, GM crops are processed into livestock feed. The land is used for cultivation of GM plants has been increased in recent years; in 2012 GM plants were grown on over 170 million hectares in 28 countries by 17.3 million farmers and extended to 185.1 million hectors in 2016 worldwide. GM plants have been used as feed for animals and the number of studies has proved their safety for animal and public health. This paper reviews the possible effects of GM crops on livestock, poultry, and aquatic anima

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25

Koloskova, E. M., VA Ezerskiy, T. P. Trubitsyna, and N. V. Belova. "Genetically modified rabbits as bio-producers and biomodels." E3S Web of Conferences 224 (2020): 04034. http://dx.doi.org/10.1051/e3sconf/202022404034.

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Genetically modified (GM) animals are necessary to solve the global problems of humanity related to nutrition and health. Rabbits, as laboratory, domestic and farm animals, occupy a special niche in research. GM rabbits are promising as bioreactors for producing biologically active (BA) proteins with milk or blood, and are in demand in Biomedicine as biomodels of diseases. To date, many GM rabbits-biomodels, producers of recombinant proteins have been created in the world using CRISPR/Cas9 technology. All-Russian Research Institute of Animal Physiology, Biochemistry and Nutrition has experienc

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26

Pribylova, R., I. Pavlik, and M. Bartos. "Genetically modified potato plants in nutrition and prevention of diseases in humans and animals: a review." Veterinární Medicína 51, No. 5 (2012): 212–23. http://dx.doi.org/10.17221/5540-vetmed.

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Genetically modified organisms (GMO) become a real constituent of our lives and nowadays, they are commonly introduced into the food chain of people and animals in some states. Among higher organisms, plants are used above all for genetic modifications; potatoes are a suitable model plants for this purpose. Nowadays, a number of various genetic modifications of potato plants are available, particularly those with increased resistance to biological agents and factors of the external environment or with improved nutritional value. Plants that produce proteins of the immune system of man or anima

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27

Голоборщева, В. В., Н. А. Воронина, Р. К. Овчинников, В. Г. Кучеряну, and С. Г. Морозов. "MPTP-induced Parkinsonism in genetically modified mice." Nauchno-prakticheskii zhurnal «Patogenez», no. 2 (June 28, 2021): 12–23. http://dx.doi.org/10.25557/2310-0435.2021.02.12-23.

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Использование экспериментальных моделей на животных является чрезвычайно ценным методом изучения патогенеза заболеваний человека и используется для разработки их эффективной терапии. В отличие от изолированных моделей in vitro, использование животных в качестве модельной системы оказалось более продуктивным для изучения мультифакториальных заболеваний или болезней, влияющих на несколько систем организма. Данный метод особенно актуален в отношении использования моделей in vivo для понимания патофизиологических механизмов расстройств центральной нервной системы, включая эпилепсию, рассеянный скл

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28

Blagoevska, K., G. Ilievska, D. Jankuloski, et al. "The controversies of genetically modified food." IOP Conference Series: Earth and Environmental Science 854, no. 1 (2021): 012009. http://dx.doi.org/10.1088/1755-1315/854/1/012009.

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Abstract The increasing use of genetically modified (GM) foods and feeds attracts the interest of media and public, causing great concern among consumers about the consequences of their consumption. The issues of concern are mainly focused on the impact on consumer health and the repercussions on the environment. The biggest fears are the possible negative consequences on human and animal health, which encompass allergic reactions, side effects such as toxicity, damage to individual organs, gene transfer and differences in nutritional value. Consumers are unsure and confused as to whether cons

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29

Reichert, Michał, Wojciech Kozaczyński, Teresa Agnieszka Karpińska, et al. "Histopathology of Internal Organs of Farm Animals Fed Genetically Modified Corn and Soybean Meal." Bulletin of the Veterinary Institute in Pulawy 56, no. 4 (2012): 617–22. http://dx.doi.org/10.2478/v10213-012-0109-y.

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Abstract Histopathological examination of liver, kidney, spleen, pancreas, duodenum, jejunum, skeletal muscle, and bursa of Fabricius samples, collected from broiler chickens, laying hens, fattening pigs, and calves fed genetically modified corn MON 810 and soybean meal MON-40-3-2 (Roundup Ready, RR), was performed The examination showed no significant differences between the control animals fed diets containing no genetically modified feeds and animals fed genetically modified feeds. In some cases, congestion of parenchyma and focal lymphoid cell infiltrations were observed in all dietary gro

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30

Rakhad Abdulrazak Alrawi and Rafal Abdulrazak Al-rawi. "Facts and horizons of genetically modified organisms/foods and health issues." World Journal of Advanced Research and Reviews 13, no. 2 (2022): 071–75. http://dx.doi.org/10.30574/wjarr.2022.13.2.0040.

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A GMO stands for genetically modified organism, whose genetic material has been artificially manipulated in a laboratory through genetic engineering. This creates plant, animal, bacteria, and virus genes that do not occur in nature. GMO foods (GMF) were introduced in the 1990s. Nowadays, GMF includes many plants and animals, whose genetic materials (DNA) structure has been modified. A biologist researcher creates GMOs by introducing genetic material, or DNA, from a different organism through a process called genetic engineering. Crops are most often genetically modified to increase production,

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31

Rakhad, Abdulrazak Alrawi, and Abdulrazak Al-rawi Rafal. "Facts and horizons of genetically modified organisms/foods and health issues." World Journal of Advanced Research and Reviews 13, no. 2 (2022): 071–75. https://doi.org/10.5281/zenodo.6244981.

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A GMO stands for genetically modified organism, whose genetic material has been artificially manipulated in a laboratory through genetic engineering. This creates plant, animal, bacteria, and virus genes that do not occur in nature. GMO foods (GMF) were introduced in the 1990s. Nowadays, GMF includes many plants and animals, whose genetic materials (DNA) structure has been modified. A biologist researcher creates GMOs by introducing genetic material, or DNA, from a different organism through a process called genetic engineering. Crops are most often genetically modified to increase production,

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32

TANAKA, Takao, Yoshihiro OOGUCHI, Yuki TOSHINARI, JiRyun KIM, and Aya NAKAI. "Generation of genetically modified animals by genome editing technology." Japanese Journal of Thrombosis and Hemostasis 26, no. 6 (2015): 626–32. http://dx.doi.org/10.2491/jjsth.26.626.

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33

FİLAZİ, Ayhan, and Leyla ÖZHANCI. "Genetically Modified Animals in Pharmacology and Toxicology Research: Review." Turkiye Klinikleri Journal of Laboratory Animals 1, no. 1 (2017): 28–40. http://dx.doi.org/10.5336/jlabanim.2016-51616.

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34

Takehashi, Masanori, Mito Kanatsu-Shinohara, and Takashi Shinohara. "Generation of genetically modified animals using spermatogonial stem cells." Development, Growth & Differentiation 52, no. 3 (2010): 303–10. http://dx.doi.org/10.1111/j.1440-169x.2009.01167.x.

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35

Polcz, Sarah, and Anna C. F. Lewis. "A Menagerie of Moral Hazards: Regulating Genetically Modified Animals." Journal of Law, Medicine & Ethics 46, no. 1 (2018): 180–84. http://dx.doi.org/10.1177/1073110518766031.

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36

Forabosco, Flavio, Fredrik L. Sundström, and Lotta Rydhmer. "An algorithm for the identification of genetically modified animals." Trends in Biotechnology 31, no. 5 (2013): 272–74. http://dx.doi.org/10.1016/j.tibtech.2013.02.001.

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37

Ninkina, N. N., A. A. Ustyugov, and V. L. Buchman. "Modeling synucleinopathies in genetically modified animals: Successes and failures." Molecular Biology 42, no. 5 (2008): 747–61. http://dx.doi.org/10.1134/s0026893308050129.

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38

Maronpot, Robert R. "The Use of Genetically Modified Animals in Carcinogenicity Bioassays." Toxicologic Pathology 28, no. 3 (2000): 450–53. http://dx.doi.org/10.1177/019262330002800316.

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39

Rodionova, A. E. "Potential hazards associated with the use of genetically modifi ed organisms in human food." Tovaroved prodovolstvennykh tovarov (Commodity specialist of food products), no. 11 (November 15, 2022): 708–14. http://dx.doi.org/10.33920/igt-01-2211-03.

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The article provides an analysis of genetically modified organisms. A scheme for their creation is given; genetically modified plants and animals, as well as potential dangers associated with the GMO use in human food are considered.

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40

Genetically, Modified Meat: Transgenesis and Cloning. "Genetically Modified Meat: Transgenesis and Cloning." Science World a monthly e magazine 3, no. 5 (2023): 639–46. https://doi.org/10.5281/zenodo.7907082.

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Meat can be defined as “the muscle tissue of slaughter animals”. It is one of the most significant human food sources since it contains a high amount of useful protein as well as important micronutrients that are necessary for human health. The FAO estimates that meat consumption in developed countries might reach 100 kg per person per year by 2030. Meat demand is expected to expand at a rate of 1.3 percent each year until 2050. According to the International Food Policy Research Institute, annual per capita meat consumption in high-income countries is expected to rise from 90 kg p

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41

Cundiff, Larry V., Michael D. Bishop, and Rodger K. Johnson. "Challenges and opportunities for integrating genetically modified animals into traditional animal breeding plans." Journal of Animal Science 71, suppl_3 (1993): 20–25. http://dx.doi.org/10.2527/1993.71suppl_320x.

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42

Knoblaugh, Sue E., Tobias M. Hohl, and Krista M. D. La Perle. "Pathology Principles and Practices for Analysis of Animal Models." ILAR Journal 59, no. 1 (2018): 40–50. http://dx.doi.org/10.1093/ilar/ilz001.

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Abstract Over 60% of NIH extramural funding involves animal models, and approximately 80% to 90% of these are mouse models of human disease. It is critical to translational research that animal models are accurately characterized and validated as models of human disease. Pathology analysis, including histopathology, is essential to animal model studies by providing morphologic context to in vivo, molecular, and biochemical data; however, there are many considerations when incorporating pathology endpoints into an animal study. Mice, and in particular genetically modified models, present unique

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43

A, Dutta, and Das E. "A Comparative Study on Transgenic Animal Breeding and Patentability Analysis in India: Reference to Animal Husbandry in Biotechnology Industries." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 16 (2024): 146–53. http://dx.doi.org/10.56557/upjoz/2024/v45i164295.

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Transgenic animal breeding or genetically modified animals are useful for various industries like the pharmaceutical industry, the agricultural industry, farming and medical research and development. In modern times the research on biotechnology and gene patent are frequently shows the urgency of development in the area of patent regimes. The United States and other developed country continue to expand their research on genetically-engineered animals and claims the patent protection. The paper aims to describes the process to evolve transgenic animals and the role in food industry. Furthermore

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44

Urban, Wiktoria, Marta Kropacz, Maksymilian Łach, and Anna Jankowska. "CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals." Current Issues in Molecular Biology 47, no. 5 (2025): 330. https://doi.org/10.3390/cimb47050330.

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CRISPR-Cas9 enables targeted genome editing and has become a pivotal tool in biomedical research and animal genome engineering. This review highlights its application in generating genetically modified animals used as preclinical disease models, bioreactors for recombinant protein production, and potential sources of xenotransplantation organs. We also discuss its role in improving livestock traits, welfare, and breeding efficiency. The benefits and limitations of CRISPR-Cas9 are examined, emphasizing its transformative potential in research and agricultural biotechnology.

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45

Deykin, Alexey V., Olesya V. Shcheblykina, Elena E. Povetka, et al. "Genetically modified animals for use in biopharmacology: from research to production." Research Results in Pharmacology 7, no. 4 (2021): 11–27. http://dx.doi.org/10.3897/rrpharmacology.7.76685.

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Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented. Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. The necessity of improving the technology of development transgenic rabbit producers and creating a platform solution for the production of biological products is substantiated. The advantages of using TrB for the production of

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46

Schuppli, Catherine A., and Daniel M. Weary. "Attitudes towards the use of genetically modified animals in research." Public Understanding of Science 19, no. 6 (2010): 686–97. http://dx.doi.org/10.1177/0963662510362834.

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47

Thorsell, A., and M. Heilig. "Diverse functions of neuropeptide Y revealed using genetically modified animals." Neuropeptides 36, no. 2-3 (2002): 182–93. http://dx.doi.org/10.1054/npep.2002.0897.

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48

Chande, Minal. "UK scientists review use of genetically modified animals in research." Lancet 357, no. 9269 (2001): 1684. http://dx.doi.org/10.1016/s0140-6736(00)04875-3.

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49

Lievens, A., M. Petrillo, M. Querci, and A. Patak. "Genetically modified animals: Options and issues for traceability and enforcement." Trends in Food Science & Technology 44, no. 2 (2015): 159–76. http://dx.doi.org/10.1016/j.tifs.2015.05.001.

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50

Forabosco, F., M. Löhmus, L. Rydhmer, and L. F. Sundström. "Genetically modified farm animals and fish in agriculture: A review." Livestock Science 153, no. 1-3 (2013): 1–9. http://dx.doi.org/10.1016/j.livsci.2013.01.002.

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