Academic literature on the topic 'Genome caretakers'

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Journal articles on the topic "Genome caretakers"

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Curcio, M. Joan, Alison E. Kenny, Sharon Moore, et al. "S-Phase Checkpoint Pathways Stimulate the Mobility of the Retrovirus-Like Transposon Ty1." Molecular and Cellular Biology 27, no. 24 (2007): 8874–85. http://dx.doi.org/10.1128/mcb.01095-07.

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ABSTRACT The mobility of the Ty1 retrotransposon in the yeast Saccharomyces cerevisiae is restricted by a large collection of proteins that preserve the integrity of the genome during replication. Several of these repressors of Ty1 transposition (Rtt)/genome caretakers are orthologs of mammalian retroviral restriction factors. In rtt/genome caretaker mutants, levels of Ty1 cDNA and mobility are increased; however, the mechanisms underlying Ty1 hypermobility in most rtt mutants are poorly characterized. Here, we show that either or both of two S-phase checkpoint pathways, the replication stress
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Chu, Wai Kit, and Ian D. Hickson. "RecQ helicases: multifunctional genome caretakers." Nature Reviews Cancer 9, no. 9 (2009): 644–54. http://dx.doi.org/10.1038/nrc2682.

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Hickson, Ian D. "RecQ helicases: caretakers of the genome." Nature Reviews Cancer 3, no. 3 (2003): 169–78. http://dx.doi.org/10.1038/nrc1012.

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Cunningham, Richard P. "DNA repair: Caretakers of the genome?" Current Biology 7, no. 9 (1997): R576—R579. http://dx.doi.org/10.1016/s0960-9822(06)00286-7.

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Lahue, Robert S., and Aisling Frizzell. "Histone deacetylase complexes as caretakers of genome stability." Epigenetics 7, no. 8 (2012): 806–10. http://dx.doi.org/10.4161/epi.20922.

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Gening, L. V., A. V. Makarova, A. M. Malashenko, and V. Z. Tarantul. "A false note of DNA polymerase iota in the choir of genome caretakers in mammals." Biochemistry (Moscow) 71, no. 2 (2006): 155–59. http://dx.doi.org/10.1134/s0006297906020064.

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Fernández-Bellon, Hugo, Jordi Rodon, Leira Fernández-Bastit, et al. "Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses." Viruses 13, no. 9 (2021): 1683. http://dx.doi.org/10.3390/v13091683.

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To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2 infection. Besides pets (cats, dogs, Syrian hamsters, and ferrets) and farm animals (minks), different zoo animal species have tested positive for SARS-CoV-2 (large felids and non-human primates). After the summer of 2020, a second wave of SARS-CoV-2 infection occurred in Barcelona (Spain), reaching
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Gening, L. V., A. V. Makarova, A. M. Malashenko, and V. Z. Tarantul. "Erratum to: A false note of DNA polymerase iota in the choir of genome caretakers in mammals." Biochemistry (Moscow) 74, no. 1 (2009): 115. http://dx.doi.org/10.1134/s0006297909010209.

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Sangkachai, Nareerat, Somjit Chaiwattanarungruengpaisan, Metawee Thongdee, et al. "Serological and Molecular Surveillance for SARS-CoV-2 Infection in Captive Tigers (Panthera tigris), Thailand." Animals 12, no. 23 (2022): 3350. http://dx.doi.org/10.3390/ani12233350.

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Coronavirus disease (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Given the emergence of SARS-CoV-2 variants, continuous surveillance of SARS-CoV-2 in animals is important. To monitor SARS-CoV-2 infection in wildlife in Thailand, we collected 62 blood samples and nine nasal- and rectal-swab samples from captive tigers (Panthera tigris) in Ratchaburi province in Thailand during 2020–2021. A plaque reduction neutralization test (PRNT) was employed to detect SARS-CoV-2 neutralizing antibodies. A real-time RT-PCR assay was performed to detect SARS-CoV-2 RNA. Our findings demon
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Leon, I. M., S. D. Lawhon, K. N. Norman, et al. "Serotype Diversity and Antimicrobial Resistance amongSalmonella entericaIsolates from Patients at an Equine Referral Hospital." Applied and Environmental Microbiology 84, no. 13 (2018): e02829-17. http://dx.doi.org/10.1128/aem.02829-17.

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ABSTRACTAlthoughSalmonella entericacan produce life-threatening colitis in horses, certain serotypes are more commonly associated with clinical disease. Our aim was to evaluate the proportional morbidity attributed to different serotypes, as well as the phenotypic and genotypic antimicrobial resistance (AMR) ofSalmonellaisolates from patients at an equine referral hospital in the southern United States. A total of 255Salmonellaisolates was obtained from clinical samples of patients admitted to the hospital between 2007 and 2015. Phenotypic resistance to 14 antibiotics surveilled by the U.S. Na
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Dissertations / Theses on the topic "Genome caretakers"

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Guillemette, Shawna S. "Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/712.

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Our genome is constantly challenged by sources that cause DNA damage. To repair DNA damage and maintain genomic stability eukaryotes have evolved a complex network of pathways termed the DNA damage response (DDR). The DDR consists of signal transduction pathways that sense DNA damage and mediate tightly coordinated reactions to halt the cell cycle and repair DNA with a collection of different enzymes. In this manner, the DDR protects the genome by preventing the accumulation of mutations and DNA aberrations that promote cellular transformation and cancer development. Loss of function mutations
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Guillemette, Shawna S. "Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/712.

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Our genome is constantly challenged by sources that cause DNA damage. To repair DNA damage and maintain genomic stability eukaryotes have evolved a complex network of pathways termed the DNA damage response (DDR). The DDR consists of signal transduction pathways that sense DNA damage and mediate tightly coordinated reactions to halt the cell cycle and repair DNA with a collection of different enzymes. In this manner, the DDR protects the genome by preventing the accumulation of mutations and DNA aberrations that promote cellular transformation and cancer development. Loss of function mutations
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Kaiser, Sebastian [Verfasser], and Caroline [Gutachter] Kisker. "A RecQ helicase in disguise: Characterization of the unconventional Structure and Function of the human Genome Caretaker RecQ4 / Sebastian Kaiser ; Gutachter: Caroline Kisker." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1206879246/34.

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Saxena, Sneha. "Role of mammalian RAD51 paralogs in replication stress response and genome maintenance." Thesis, 2019. https://etd.iisc.ac.in/handle/2005/5588.

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The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has contributed to identify unanticipated functions of these genome caretakers in the cellular response to replication stress and accompanying repair mechanisms. These include maintenance of cellular nucleotide pools through the regulation of ribonucleotide reductase (RNR), modulation of replication fork progression during nucleotide pool alterations and protection of stressed
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Kaiser, Sebastian. "A RecQ helicase in disguise: Characterization of the unconventional Structure and Function of the human Genome Caretaker RecQ4." Doctoral thesis, 2020. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-160414.

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From the simplest single-cellular organism to the most complex multicellular life forms, genetic information in form of DNA represents the universal basis for all biological processes and thus for life itself. Maintaining the structural and functional integrity of the genome is therefore of paramount importance for every single cell. DNA itself, as an active and complex macromolecular structure, is both substrate and product of many of these biochemical processes. A cornerstone of DNA maintenance is thus established by the tight regulation of the multitude of reactions in DNA metabolism, repre
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