Relevant bibliographies by topics / Genome editors

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Genome editors'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Genome editors"

1

Goodman, L. "New Editors Join Genome Research." Genome Research 12, no. 8 (2002): 1151. http://dx.doi.org/10.1101/gr.572802.

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Scheben, Armin, and David Edwards. "Genome editors take on crops." Science 355, no. 6330 (2017): 1122–23. http://dx.doi.org/10.1126/science.aal4680.

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Molla, Kutubuddin A., Simon Sretenovic, Kailash C. Bansal, and Yiping Qi. "Precise plant genome editing using base editors and prime editors." Nature Plants 7, no. 9 (2021): 1166–87. http://dx.doi.org/10.1038/s41477-021-00991-1.

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Evanoff, Mallory, and Alexis C. Komor. "Base editors: modular tools for the introduction of point mutations in living cells." Emerging Topics in Life Sciences 3, no. 5 (2019): 483–91. http://dx.doi.org/10.1042/etls20190088.

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Base editors are a new family of programmable genome editing tools that fuse ssDNA (single-stranded DNA) modifying enzymes to catalytically inactive CRISPR-associated (Cas) endonucleases to induce highly efficient single base changes. With dozens of base editors now reported, it is apparent that these tools are highly modular; many combinations of ssDNA modifying enzymes and Cas proteins have resulted in a variety of base editors, each with its own unique properties and potential uses. In this perspective, we describe currently available base editors, highlighting their modular nature and describing the various options available for each component. Furthermore, we briefly discuss applications in synthetic biology and genome engineering where base editors have presented unique advantages over alternative techniques.
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Leslie, Mitch. "‘Old’ genome editors might treat mitochondrial diseases." Science 361, no. 6409 (2018): 1302. http://dx.doi.org/10.1126/science.361.6409.1302.

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Burt, Austin, and Anne Deredec. "Self-limiting population genetic control with sex-linked genome editors." Proceedings of the Royal Society B: Biological Sciences 285, no. 1883 (2018): 20180776. http://dx.doi.org/10.1098/rspb.2018.0776.

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In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. With simple population genetic and dynamic models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be an attractive option to consider when efficient control of a species is desired in some locales but not others.
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Anzalone, Andrew V., Luke W. Koblan, and David R. Liu. "Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors." Nature Biotechnology 38, no. 7 (2020): 824–44. http://dx.doi.org/10.1038/s41587-020-0561-9.

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Monsur, Mahmuda Binte, Gaoneng Shao, Yusong Lv, et al. "Base Editing: The Ever Expanding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Tool Kit for Precise Genome Editing in Plants." Genes 11, no. 4 (2020): 466. http://dx.doi.org/10.3390/genes11040466.

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Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9), a newly developed genome-editing tool, has revolutionized animal and plant genetics by facilitating modification of target genes. This simple, convenient base-editing technology was developed to improve the precision of genome editing. Base editors generate precise point mutations by permanent base conversion at a specific point, with very low levels of insertions and deletions. Different plant base editors have been established by fusing various nucleobase deaminases with Cas9, Cas13, or Cas12a (Cpf1), proteins. Adenine base editors can efficiently convert adenine (A) to guanine (G), whereas cytosine base editors can convert cytosine (C) to thymine (T) in the target region. RNA base editors can induce a base substitution of A to inosine (I) or C to uracil (U). In this review, we describe the precision of base editing systems and their revolutionary applications in plant science; we also discuss the limitations and future perspectives of this approach.
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Tan, Wenfang, Chris Proudfoot, Simon G. Lillico, and C. Bruce A. Whitelaw. "Gene targeting, genome editing: from Dolly to editors." Transgenic Research 25, no. 3 (2016): 273–87. http://dx.doi.org/10.1007/s11248-016-9932-x.

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Hölttä, Mikko, Roberto Nitsch, and Neil Henderson. "Bioanalytical challenges and strategies of CRISPR genome editors." Bioanalysis 13, no. 3 (2021): 169–79. http://dx.doi.org/10.4155/bio-2020-0215.

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Genome editing using clustered regularly interspaced short palindromic repeats (CRISPR) has been used to great effect in vitro to allow scientists to more rapidly investigate molecular pathways that may be involved in disease. The logical progression for the CRISPR machinery is to move from bench to bedside into the world of therapeutics and clinical diagnostics. Depending upon the intended therapeutic use of CRISPR, there are as many bioanalytical challenges in order to resolve scientific questions as drug development and regulatory questions. The aim of this article is to highlight bioanalytical challenges associated with such a powerful therapeutic tool, and strategies that may be required to facilitate the clinical development of CRISPR.
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Dissertations / Theses on the topic "Genome editors"

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Huddart, Rachel Anne. "Investigating agricultural and biomedical applications of genome editors in large animals." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19512.

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Large animal species, such as cattle, sheep and pigs, have great potential value to scientific research. This is due to their physiological similarity to humans, meaning they make excellent disease models in addition to their inherent agricultural value. However, the efficiency with which such animals can be created has been a critical barrier to their use in bioscience. Research into creating genetically modified large animals has not progressed as rapidly as research on smaller mammals, such as mice, for two main reasons. Firstly, technologies such as pluripotent stem cells, which are well established in rodents, are lacking for large animals. Secondly, large animals cannot produce as many offspring within a given time frame as mice or rats. This, combined with the low efficiencies and lack of precision of current transgenic methods, severely reduces the likelihood of obtaining an animal with a desired genotype within a viable amount of time. Recently, new tools known as ’genome editors’ have been developed to facilitate genetic modification of animals. The vastly enhanced efficiency of these editors in comparison to previous gene targeting methods, combined with the fact that genome editors do not require marker genes to be used, mean that creating genetically modified livestock is now far more feasible. This thesis investigates whether two types of genome editor, TALENs and CRISPR/Cas9, can be used to produce genetically modified large animals for a range of applications. Genome editors were combined with interspecific blastocyst complementation techniques to produce chimeric rodents where the haematopoietic system is partially or fully derived from the donor cells. This work was carried out with a long-term aim of producing chimeric animals which could produce human organs suitable for transplantation. Initial blastocyst complementation experiments were carried out by injecting murine ESCs into wildtype rat blastocysts. One animal resulting from these injections showed chimerism in several tissues. Further experiments were carried out using rat ESCs and mouse blastocysts which were either Runx1-/- or Rag1-/-, however no additional chimeras were identified. In addition to these experiments, TALENs and sgRNAs were designed against Runx1 and Rag1 in sheep and pigs in order to create a large animal model for future blastocyst complementation experiments. Increasing animal productivity is a key step in meeting the demands of an increasing global population and tackling future food insecurities. TALENs and sgRNAs for use in the CRISPR/ Cas9 system were created to target the myostatin gene in sheep. Myostatin is a negative regulator of muscle growth and animals which acquire natural inactivating mutations in both myostatin alleles exhibit a well-characterised double-muscled phenotype, where total muscle mass is about 20% greater than that of a wildtype animal. Embryo microinjections were carried out using both types of genome editor and two edited lambs were produced, one from each editor. The TALEN-edited lamb was mosaic for a deletion of arginine 283 which, upon further analysis of the muscle, did not appear to cause a significant phenotype. The CRISPR-edited lamb was heterozygous for a 20bp deletion, causing the formation of a premature stop codon and severe truncation of the mature myostatin protein. Based on data from other myostatin-knockout animals, including the Belgian Blue cattle breed, this truncated protein is not thought to be functional. To determine if this is indeed the case, the CRISPR-edited lamb is now part of a breeding programme to amplify the edited allele. To discover if genome editors could be applied to create disease-resistant animals, the project focused on foot and mouth disease. Through a literature search and bioinformatic analysis of the bovine and porcine proteomes, three host genes which are cleaved by the virus were identified; eIF4A1, eIF4G1 and IKBKG. TALENs were designed to bind and cut at the FMDV protease cleavage sites in all three genes in order to disrupt protease cleavage and reduce viral replication by slowing viral disruption of the host translation and innate immune response pathways. Although none of the TALENs showed any signs of activity, this thesis sets out some potential directions for future work. In conclusion, this thesis shows that, despite some technical issues, genome editors are a promising technology for the creation of genetically modified livestock.
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Amai, Takamitsu. "Development of genome editing technology of mitochondrial DNA in Saccharomyces cerevisiae." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263707.

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Jakimo, Noah Michael. "Precise and expansive genomic positioning for CRISPR edits." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123626.

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Thesis: Ph. D., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 91-105).<br>The recent harnessing of microbial adaptive immune systems, known as CRISPR, has enabled genome-wide engineering across all domains of life. A new generation of gene-editing tools has been fashioned from the natural DNA/RNA-targeting ability of certain CRISPR-associated (Cas) proteins and their guide RNA, which work together to recognize and defend against infectious genetic threats. This straight-forward RNA-programmed sequence recognition by CRISPR has facilitated its rapid global impact on genetic research, diagnostics, therapeutics, and bioproduction. An ideal DNA-editing platform would achieve perfect accuracy on any desired cellular and genomic target. CRISPR systems, however, have limited target fidelity and range, in part due to their evolutionary pressures to defend microbes from fast-mutating viruses without self-targeting their own guide RNA.<br>These natural limitations of CRISPR can especially constrain gene-editing in animals and plants, which are more vulnerable to off-target activity occurring in one of their trillions of cells with genomes that are 1000x larger than those of unicellular microbes that natively harbor CRISPR systems. This thesis overcomes three critical challenges for precise and broad gene-editing of complex organisms: 1) engineering a means of specificity for the type of cells to edit, 2) improving target-matching accuracy, and 3) broadening the editable portion of the genome.<br>This thesis addresses these challenges by integrating custom developed computational design tools and biological validation of the resulting novel CRISPR systems; 1) To target within multicellular heterogeneity, new oligonucleotide-sensing structural motifs are designed and embed into guides that can potentially control CRISPR nuclease activity based on cell-type transcriptome patterns; 2) To discern among increased similarity between a target and non-target sequences in larger genomes, base-pairing thermostability principles are employed to tune the biochemical composition of guides that can evade subtly mismatched off-target sites; 3) To expand the reach of editing techniques with narrow windows of operation, such as base-editing, bioinformatics workflows that discover previously uncharacterized Cas proteins with novel target scope are created.<br>This thesis demonstrates the effectiveness of these strategies in the context of in vitro, bacterial, and human cell culture assays, and contributes advancements in the precision and generality for CRISPR gene-editing.<br>by Noah Michael Jakimo.<br>Ph. D.<br>Ph.D. Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences
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Books on the topic "Genome editors"

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Fulvi, Antonio. La storia della nautica in 50 edizioni del Salone nautico internazionale di Genova =: Editions of International Boat Show of Genoa. Sagep, 2010.

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Franchini, Silvia. Diventare grandi con il "Pioniere", 1950-1962: Politica, progetti di vita e identità di genere nella piccola posta di un giornalino di sinistra. Firenze University Press, 2006.

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Toor, David, ed. Twelfth Night by William Shakespeare: Stage Edition: Designed for use in stage productions of the play with an introduction by the editor. Kenilworth Press, 2000.

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Davis, Joel L. Mapping the Code: The Human Genome Project and the Choices of Modern Science (Wiley Science Editions). Wiley, 1991.

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Franklin, Carmela Vircillo. Theodor Mommsen, Louis Duchesne, and the Liber pontificalis. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198818489.003.0005.

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This chapter juxtaposes the theory and the practice of philology in the late nineteenth-century race to produce a modern critical edition of the Liber pontificalis. The resulting works, one by the French priest and church historian Louis Duchesne, the other by the classicist and German patriot Theodor Mommsen, showcase the editors’ divergent aims in the application of recensionist criticism, shaped as it was by their scholarly, national, religious, and personal loyalties. Mommsen’s edition adheres to the principles of ‘German’ critical philology and its desire to recover the original text; Duchesne’s two volumes exploit the nature of the medieval papal chronicle as a constantly changing ‘living text’ in order to emphasize the historical significance of its reception. Both editions illustrate the themes of marginality and canonicity as they relate to literary genre and historical period, to religious commitment and national sentiment, and to the tension between classical methodology and medieval texts.
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Little, Katherine C., and Nicola McDonald. Introduction. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198795148.003.0001.

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In their Introduction, the editors argue that romance—a genre invented in the twelfth century as a new mode of storytelling and distinguished, throughout the period, for its confident, ambitious modernity—is one of the most important if unexpected sites for, and modes of, medieval thinking, especially about things that were elsewhere unthinkable. The Introduction also provides an overview of the eleven chapters in the volume, one that highlights their coverage (French, Middle English and Anglo-Norman), their interdisciplinarity, and their provocative insights into romance thought on politics, religion, music, the romance genre, and on the nature of romance thinking itself.
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Telotte, J. P. Movies, Modernism, and the Science Fiction Pulps. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190949655.001.0001.

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This book considers the impact that the new art of film had on the development of the emerging science fiction (SF) genre during the pre- and early post-World War II era, during the time that the genre was trying to locate an identity, develop its key themes, and even settle on a name. Focusing on the primary venue for early SF literature, the popular pulp magazines such as Amazing Stories, Wonder Stories, and Astounding Stories, it traces this early film/literature relationship by examining four common features of the pulps: stories that involve film or the film industry; film-related advertising; editors’ commentaries and readers’ remarks on film; and cover and story illustrations. All these features demonstrate an interest and even a fascination with the movies, which, as many of SF’s readers, writers, and editors recognized, demonstrated a modernist agenda similar to that which characterized the literature. By surveying these haunting traces of another medium in early SF discourse, this book shows how that cinematic influence penetrated and, both consciously and unconsciously, helped shape the experience of SF, as well as the cultural idea of SF during this formative period.
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Wolfgang, Holzgreve, and Lessl M. 1966-, eds. Stem cells from cord blood, in utero stem cell development, and transportation-inclusive gene therapy /cW. Holzgreve, M. Lessl, editors. Springer, 2001.

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Duffy, Brooke Erin. Making the Magazine. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252037962.003.0002.

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This chapter traces the history of women's magazines that spans 300 years. Drawing upon four decades of scholarship on women's magazines, it examines the defining properties of the genre, and particularly the consideration that these periodicals are created exclusively for and targeted to female audiences. It also discusses the ways in which editors-in-chief create and maintain the identity of their publications while establishing the magazine as an intimate imagined space, and how consumerism and citizenship became intertwined in women's magazines. The chapter shows that the history of women's magazines has been defined by the creation of imagined communities of interest, the increasing specialization of titles, and the symbiosis of the magazine and advertising industries.
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Cook, Daniel, James Morris, Valentina Bond, and Monica Burns. The Private Memoirs and Confessions of a Justified Sinner: The Dundee Edition. UniVerse, 2021. http://dx.doi.org/10.20933/100001190.

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Published anonymously in 1824, The Private Memoirs and Confessions of a Justified Sinner: Written by Himself: With a detail of curious traditionary facts and other evidence by the editor pushed the boundaries of genre. It has been called a Gothic novel, a psychological mystery, a religious satire, and an early example of modern crime fiction. The plot follows a staunch Calvinist, Robert Wringhim, who believes he is justified in killing those he believes are already damned by God. A masterclass of metafiction, many of the events are narrated twice; first by the 'editor', who gives his account of the facts as he understands them to be, and then in the words of the 'sinner' himself. Having sold poorly among its first readers, the novel suffered from a prolonged period of neglect. However, since the latter part of the twentieth century it has won greater critical interest and attention.
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Book chapters on the topic "Genome editors"

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Cullis, Christopher A., and Margaret A. Cullis. "Flax Genome “Edits” in Response to the Growth Environment." In Genetics and Genomics of Linum. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23964-0_15.

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Kroll, Carolin, and Philipp Rathert. "Stable Expression of Epigenome Editors via Viral Delivery and Genomic Integration." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7774-1_11.

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Valente, Louis, Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa, and Kazuko Nishikura. "Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing." In Posttranscriptional Gene Regulation. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527665433.ch3.

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"About the editors." In Genome Engineering via CRISPR-Cas9 System. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-818140-9.11001-3.

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Fräbel, Sabine, Shai J. Lawit, Jingyi Nie, David G. Schwark, Thomas J. Poorten, and Nathaniel D. Graham. "Progress in precise and predictable genome editing in plants with base editing." In Genome editing for precision crop breeding. Burleigh Dodds Science Publishing, 2021. http://dx.doi.org/10.19103/as.2020.0082.06.

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Base editors are gene editing tools that allow targeted nucleic acid conversions, most commonly C&gt;T and A&gt;G, through pairing of deamination domains with impaired nucleases. Multiple deaminase domains and architectures have been demonstrated in planta across a wide array of species, with both cytosine and adenine base editing frequencies being observed at over 80%. The ability of base editors to introduce nucleic acid diversity while maintaining the same reading frame should make them powerful tools for plant genetic editing moving forward.
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"Editor’s biographies." In The Human Mitochondrial Genome. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-819656-4.00027-9.

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"ABOUT THE EDITOR." In The Evolution of the Genome. Elsevier, 2005. http://dx.doi.org/10.1016/b978-012301463-4/50002-4.

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"About the Editors." In Genomic Biomarkers for Pharmaceutical Development. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-397336-8.00015-x.

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Clarke, Clare. "‘I simply write it to order’: L. T. Meade, Sisters of Sherlock, and the Strand Magazine." In Women, Periodicals and Print Culture in Britain, 1830s-1900s. Edinburgh University Press, 2019. http://dx.doi.org/10.3366/edinburgh/9781474433907.003.0030.

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Clare Clarke’s essay illuminates the adroit professionalism of the Irish author, journalist, and editor L. T. Meade (1844–1914) in the context of the extensive catalogue of detective fiction she contributed to the Strand Magazine (1891–1950). Meade’s foray into the detective genre followed an enormously successful period of writing novels for girls, as well as a stint at editing the girls’ magazine Atalanta (1887–98). As Clarke demonstrates, this radical departure from her literary focus on girls’ print culture is indicative of Meade’s ‘market acuity, her ability to produce precisely those genres which were in demand by periodical editors–in her own terms, her ability to give a literary editor “what his public want[s]”’ (p. 474). Meade’s talent for tapping into market trends and producing copy that catered to the tastes of readers ultimately secured her position as a regular contributor in the male-dominated Strand Magazine.
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Greig, Matilda. "Scribblomania." In Dead Men Telling Tales. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192896025.003.0006.

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The end of the Napoleonic Wars coincided with a phenomenal rise in the number and variety of war memoirs being written by veterans of all ranks, yet historians have mostly argued that these books made little impact on the general reading public. This chapter overturns that idea. It uses research into publishers’ archives, library catalogues, and later editions of Peninsular War memoirs to demonstrate that these soldiers’ tales sold well, made significant profits for their editors and publishers, and became increasingly imitated and parodied as the nineteenth century went on (including by Sherlock Holmes author Arthur Conan Doyle). It argues that these books should be seen as part of a commercial genre of war writing, with the curated representations of conflict they contained being deliberately marketed to different readers via cheap or luxury editions, illustrations, and decorative bindings.
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Conference papers on the topic "Genome editors"

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Cuff, Xavier, Miquel Villanueva, Andres El-Fakdi, et al. "Team-based workshop to engage young students in engineering and science: Building and driving a ROV (R2B2). Two special editions in India." In OCEANS 2015 - Genova. IEEE, 2015. http://dx.doi.org/10.1109/oceans-genova.2015.7271409.

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Egorova, S. D., A. Lock, and M. G. Nechaev. "COMICS DEVELOPMENT FACTORS IN RUSSIA FOR THE INTERNATIONAL MARKET." In TWEET-FENTS. Новосибирский государственный университет архитектуры, дизайна и искусств им. А.Д. Крячкова, 2020. http://dx.doi.org/10.37909/978-5-89170-266-0-2020-1011.

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The comic combines the features of such art forms as literature and fine art. They have long been present in the media and, as a rule, are now being worked on in large editions. In America, Japan and Europe, the comics industry is no less developed than the cinema and television industry, literature and video games. In Russia, comics as a genre arestill in their infancy.
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McEwan, Brigid, Meghna Kuppuraju, Zinkal Padalia, Jonathan Terrett, and Demetrios Kalaitzidis. "Abstract 880: Allogeneic CAR-T cell products containing 10 gene edits using CRISPR/Cas9 can retain full functionalityin vivoandin vitro." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-880.

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