Relevant bibliographies by topics / Genome-wide methylation

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Academic literature on the topic 'Genome-wide methylation'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Genome-wide methylation"

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Bibikova, Marina, and Jian‐Bing Fan. "Genome‐wide DNA methylation profiling." Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2, no. 2 (2010): 210–23. http://dx.doi.org/10.1002/wsbm.35.

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Rukova, B., R. Staneva, S. Hadjidekova, G. Stamenov, V. Milanova, and D. Toncheva. "Genome-Wide Methylation Profiling of Schizophrenia." Balkan Journal of Medical Genetics 17, no. 2 (2014): 15–23. http://dx.doi.org/10.2478/bjmg-2014-0070.

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Abstract Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution. We have performed 26 high-resolution genomewide methylation array analyses to determine the methylation status of 27,627 CpG islands and compared the data between patients and healthy controls. Methylation profiles of DNAs were analy
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Saied, Marwa, Sabah Khaled, Thomas Down, et al. "Genome Wide Study of DNA Methylation In AML." Blood 116, no. 21 (2010): 3618. http://dx.doi.org/10.1182/blood.v116.21.3618.3618.

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Abstract Abstract 3618 DNA methylation is the most stable epigenetic modification and has a major role in cancer initiation and progression. The two main aims for this research were, firstly, to use the genome wide analysis of DNA methylation to better understand the development of acute myeloid leukemia (AML). The second aim was to detect differentially methylated genes/regions between certain subtypes of AML and normal bone marrow (NBM). We used the methylated DNA immunoprecipitation technique followed by high-throughput sequencing by Illumina Genome Analyser II (MeDIP -seq) for 9 AML sample
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Naqvi, Hanyia, Ysabel Ilagan, Graciela Krikun, and Hugh S. Taylor. "Altered Genome-Wide Methylation in Endometriosis." Reproductive Sciences 21, no. 10 (2014): 1237–43. http://dx.doi.org/10.1177/1933719114532841.

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Flintoft, Louisa. "Genome-wide views of methylation readers." Nature Reviews Genetics 14, no. 6 (2013): 369. http://dx.doi.org/10.1038/nrg3509.

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Samarakoon, PS. "Epigenomics and Genome Wide Methylation Profiling." Sri Lanka Journal of Bio-Medical Informatics 1, no. 1 (2010): 53. http://dx.doi.org/10.4038/sljbmi.v1i1.1486.

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Figueroa, Maria Eugenia, John Greally, Ruud Delwel, and Ari M. Melnick. "Genome-Wide Epigenetics in Myeloid Leukemias." Blood 112, no. 11 (2008): sci—35—sci—35. http://dx.doi.org/10.1182/blood.v112.11.sci-35.sci-35.

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Abstract While the role of genetic alterations in cancer is well-recognized, epigenetic deregulation has only recently been identified as a hallmark of malignant transformation. The term “epigenetic” refers to a heritable regulation of gene expression that is not dependent on changes in the DNA sequence. These epigenetic modifications – including but not limited to DNA methylation and covalent modifications of histone tails – play a crucial role in determining chromatin structure and gene expression. Abnormal epigenetic regulation can lead to aberrant chromatin structure and deregulation of tr
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Lu, Tzu-Pin, Nai-Chen Chuang, Chin-Yu Cheng, et al. "Genome-wide methylation profiles in coronary artery ectasia." Clinical Science 131, no. 7 (2017): 583–94. http://dx.doi.org/10.1042/cs20160821.

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Coronary artery ectasia (CAE) is a disease characterized by abnormally dilated coronary arteries. The mechanism of CAE remains unclear, and its treatment is limited. Previous studies have shown that risk factors for CAE were related to changes in DNA methylation. However, no systematic investigation of methylation profiles has been performed. Therefore, we compared methylation profiles between 12 CAE patients and 12 propensity-matched individuals with normal coronary arteries using microarrays. Wilcoxon's rank sum tests revealed 89 genes with significantly different methylation levels (P<0.
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Yu, Ming, Sean K. Maden, Matthew Stachler, et al. "Subtypes of Barrett’s oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis." Gut 68, no. 3 (2018): 389–99. http://dx.doi.org/10.1136/gutjnl-2017-314544.

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ObjectiveTo identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett’s oesophagus (BE).DesignWe performed genome-wide DNA methylation profiling on samples of non-dysplastic BE from cancer-free patients (n=59), EAC (n=23), normal squamous oesophagus (n=33) and normal fundus (n=9), and identified methylation subtypes using a recursively partitioned mixture model. We assessed genomic alterations for 9 BE and 22 EAC samples with massively parallel sequencing of 243 EAC-associated genes, and we conducted integrative analyses with transcriptome
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Chandrasekhar, Manikala, Anilkumar Chandrappa, Rameswar Prasad Sah, et al. "AMP-PCR-based assay for detection and quantification of genome wide natural methylation in rice." Indian Journal of Genetics and Plant Breeding (The) 84, no. 04 (2024): 635–43. https://doi.org/10.31742/isgpb.84.4.14.

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Natural and artificial selection efforts combined several favorable alleles of economically important traits in crop plants. However, the progress made is insufficient to meet the future food requirements. Hence, exploring new genetic resources and breeding strategies is important for sustainable improvement in production. The epigenetic variation that alters the phenotype expression without altering the gene sequence has played a crucial role in the process of evolution of modern-day crop plants. The methylation-based epigenetic variations are known to inherit more consistently than other typ
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Dissertations / Theses on the topic "Genome-wide methylation"

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Nilsson, Emil. "Genome wide methylation analysis and obesity related traits." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248685.

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The most studied form of epigenetics is DNA methylation and several studies have investigated the link between the methylome and body weight. In paper I we analyzed the methylation profile of whole blood in 46 subjects measured with Illumina 27K chip. We provide evidence that obesity influences age driven epigenetic changes. These identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases. In paper II we studied the effect of bariatric surgery, and subsequent weight loss, on methylation and relating this to norm
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Swan, Elizabeth Joy. "Diabetic kidney disease : genome wide analyses for SNPs and methylation." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696325.

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Familial clustering of diabetic kidney disease (DKD) suggests the existence of a genetic predisposition towards the development of the disease. DKD continues to be the leading cause of end-stage renal disease (ESRD) worldwide. The identification of factors associated with a higher risk of DKD is an important scientific goal. Novel biomarkers associated with DKD may prove useful for the clinical prediction of DKD. At the beginning of this project the key research theme was to explore the genome-wide association study (GWAS) data generated by the GEnetics of Nephropathy, an International Effort
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Lienhard, Matthias [Verfasser]. "Computational Analysis of Genome-wide Methylation Enrichment Experiments / Matthias Lienhard." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1143596005/34.

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Guo, Cheng. "GENOME WIDE ANALYSES OF ALTERNATIVE POLYADENYLATION IN ARABIDOPSIS." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1479081485753738.

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Walker, Caroline Gwendolyn. "Genome-wide transcriptional and DNA methylation profiling of the bovine endometrium." Thesis, University of Auckland, 2012. http://hdl.handle.net/2292/19432.

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The aim of this research was to identify key molecular mechanisms regulating early pregnancy events in dairy cattle. Genome-wide gene expression and DNA methylation profiles were characterised in the endometrium of fertile and sub-fertile dairy cows at day 17 of pregnancy and the oestrous cycle. Gene expression data in combination with QTL data was then used to identify candidate genes for genetic analysis. The results of this study identified several biological processes likely to be important contributors to pregnancy success. In particular, genes classified as having roles in immune r
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Jiang, Ruiwei. "Genome-wide analysis of DNA methylation variance in healthy human subjects." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52977.

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DNA methylation is a type of epigenetic modification that modulates gene expression by acting as an intermediate between genes and environment; this in turn could trigger phenotypic changes with widespread implications in both disease and population models. Unlike DNA sequence, which is relatively stable and finite, DNA methylation presents itself differently in different tissues, and it is described as the sum of interactions affecting attachment of methyl groups to DNA mostly as a result of development and aging, with minor influences from stochastic variability, and environmental factors. M
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Price, Eva Magdalena Wagner. "DNA methylation in human development : methodologies and analytics for genome-wide studies." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57845.

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High-throughput methods have resulted in a large volume of studies measuring genome-wide DNA methylation (DNAm) in association with human health and disease. Understanding of DNAm patterns may be translated, for example, into predicting children at risk for illness or identifying etiological subtypes within a heterogeneous disease. Addressing biological and technical factors affecting measurement of genome-wide DNAm is essential to reduce false discovery in such studies. This dissertation develops principles for analyzing genome-wide DNAm, with the aim of improving collection and analysis of h
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Najgebauer, H. "Genome-wide DNA methylation and gene expression profiling of cancer-associated myofibroblasts." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001706/.

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In recent years it has become increasingly apparent that tumour development and metastasis are not simply driven by mutations within cancer cells. Factors produced by stromal myofibroblasts play a key role in the development and metastasis of many forms of cancer. However, our knowledge of the range of molecular mechanisms that drive paracrine communication between cancer and stromal cells remains incomplete. Evidence from previous studies show that myofibroblasts derived from gastric tumours (CAMs) not only retain their ability to enhance the proliferation and migration of cancer cells in vit
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Gerring, Zachary F. "Integrating genome-wide association and blood genomic profiling data to characterise migraine risk loci." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/112796/1/Zachary_Gerring_Thesis.pdf.

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This thesis involved a multi-staged integrated study of gene expression, DNA methylation, and DNA sequence variation data in a large sample of migraine cases and non-migraine controls. The analysis and integration of these data identified molecular perturbations associated with migraine, and prioritised migraine susceptibility genes for further functional characterisation. The use of multiple molecular data to study existing migraine loci has the potential to provide a substantial contribution to understanding the underlying genetic architecture and biological mechanisms of migraine, and may h
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Yeung, Kit-san, and 楊傑燊. "The use of genome-wide DNA methylation microarray to study both the common and rare diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207174.

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Books on the topic "Genome-wide methylation"

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Sobolev, Martha. Inter-individual variations in genome-wide DNA methylation patterns in the human germline. 2006.

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Holroyd, Christopher R., Nicholas C. Harvey, Mark H. Edwards, and Cyrus Cooper. Environment. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0038.

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Musculoskeletal disease covers a broad spectrum of conditions whose aetiology comprises variable genetic and environmental contributions. More recently it has become clear that, particularly early in life, the interaction of gene and environment is critical to the development of later disease. Additionally, only a small proportion of the variation in adult traits such as bone mineral density has been explained by specific genes in genome-wide association studies, suggesting that gene-environment interaction may explain a much larger part of the inheritance of disease risk than previously thoug
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Holroyd, Christopher R., Nicholas C. Harvey, Mark H. Edwards, and Cyrus Cooper. Environment. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0038_update_001.

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Musculoskeletal disease covers a broad spectrum of conditions whose aetiology comprises variable genetic and environmental contributions. More recently it has become clear that, particularly early in life, the interaction of gene and environment is critical to the development of later disease. Additionally, only a small proportion of the variation in adult traits such as bone mineral density has been explained by specific genes in genome-wide association studies, suggesting that gene-environment interaction may explain a much larger part of the inheritance of disease risk than previously thoug
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Book chapters on the topic "Genome-wide methylation"

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Unterberger, Alexander, Adrian M. Dubuc, and Michael D. Taylor. "Genome-Wide Methylation Analysis." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-612-8_19.

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Sharma, Neeti, and Anshika N. Singh. "Bioinformatics of Genome-wide DNA Methylation Studies." In Bioinformatics and Human Genomics Research. CRC Press, 2021. http://dx.doi.org/10.1201/9781003005926-9.

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Yegnasubramanian, Srinivasan, and William G. Nelson. "Genome-Wide DNA Methylation Analysis in Cancer Research." In Modern Molecular Biology. Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-69745-1_4.

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Mancia, Annalaura. "Genome-Wide DNA Methylation Protocol for Epigenetics Studies." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2313-8_2.

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Suzuki, Masako, and John M. Greally. "HELP-Tagging: Tag-Based Genome-Wide Cytosine Methylation Profiling." In Tag-Based Next Generation Sequencing. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527644582.ch18.

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Kerick, Martin, Axel Fischer, and Michal-Ruth Schweiger. "Generation and Analysis of Genome-Wide DNA Methylation Maps." In Bioinformatics for High Throughput Sequencing. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0782-9_9.

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Shen, Yin, Shaun D. Fouse, and Guoping Fan. "Genome-Wide DNA Methylation Profiling: The mDIP-Chip Technology." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-280-9_13.

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Philippe, Claude, and Gael Cristofari. "Genome-Wide Young L1 Methylation Profiling by bs-ATLAS-seq." In Transposable Elements. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2883-6_8.

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Hammoud, Saher Sue, Bradley R. Cairns, and Douglas T. Carrell. "Analysis of Gene-Specific and Genome-Wide Sperm DNA Methylation." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-038-0_39.

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Lin, Qiong, Wolfgang Wagner, and Martin Zenke. "Analysis of Genome-Wide DNA Methylation Profiles by BeadChip Technology." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-547-7_3.

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Conference papers on the topic "Genome-wide methylation"

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Song, Min-Ae, Maarit Tiirikainen, Gordon Okimoto, et al. "Abstract 4998: Genome-wide methylation profiling in hepatocellular carcinoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4998.

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Olson, Janet E., Mine S. Cicek, Brooke L. Fridley, et al. "Abstract 5008: Genome-wide methylation and ovarian cancer survival." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5008.

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Sanchez, Robersy, and Sally Mackenzie. "Genome-wide Discriminatory Information Patterns of Cytosine DNA Methylation." In MOL2NET. MDPI, 2016. http://dx.doi.org/10.3390/mol2net-1-e001.

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Sanchez, Robersy, and Sally Mackenzie. "Genome-wide Discriminatory Information Patterns of Cytosine DNA Methylation." In MOL2NET, International Conference on Multidisciplinary Sciences. MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-e003.

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Shen, Jing, Shuang Wang, Yujing Zhang, et al. "Abstract 4996: Genome-wide DNA methylation profiles in hepatocellular carcinoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4996.

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DeMeo, Dawn, Weiliang Qiu, Helene Bacherman, et al. "Genome-Wide DNA Methylation As A Peripheral Biomarker Of Emphysema." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4093.

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Yu, Ming, Sean Maden, Andrew Kaz, et al. "Abstract 2780: Genome-wide methylation analysis reveals methylator subtypes of Barrett's esophagus and esophageal adenocarcinoma." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2780.

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Shiao, S. Pamela, Haiyan Xiao, Lixin Dong, and Lufei Young. "Abstract LB-095: Genome-wide methylation in colorectal cancer and obesity." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-095.

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Kim, Eun-Hye, Ae-Kyung Park, Ahn Jung-Hyuck, and Woong-Yang Park. "Abstract B7: Genome-wide analysis of CpG methylation for the radiosensitivity." In Abstracts: AACR International Conference on Translational Cancer Medicine-- Jul 11-14, 2010; San Francisco, CA. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1078-0432.tcmusa10-b7.

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Marin Trigo, Jose M., David Sanz-Rubio, Ana V. Gil, et al. "Genome-wide methylation profile and gene expression in Obstructive Sleep Apnoea." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa1756.

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Reports on the topic "Genome-wide methylation"

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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien
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Eshed-Williams, Leor, and Daniel Zilberman. Genetic and cellular networks regulating cell fate at the shoot apical meristem. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699862.bard.

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The shoot apical meristem establishes plant architecture by continuously producing new lateral organs such as leaves, axillary meristems and flowers throughout the plant life cycle. This unique capacity is achieved by a group of self-renewing pluripotent stem cells that give rise to founder cells, which can differentiate into multiple cell and tissue types in response to environmental and developmental cues. Cell fate specification at the shoot apical meristem is programmed primarily by transcription factors acting in a complex gene regulatory network. In this project we proposed to provide si
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