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Dissertations / Theses on the topic 'Genome-wide methylation'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Nilsson, Emil. "Genome wide methylation analysis and obesity related traits." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248685.

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The most studied form of epigenetics is DNA methylation and several studies have investigated the link between the methylome and body weight. In paper I we analyzed the methylation profile of whole blood in 46 subjects measured with Illumina 27K chip. We provide evidence that obesity influences age driven epigenetic changes. These identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases. In paper II we studied the effect of bariatric surgery, and subsequent weight loss, on methylation and relating this to norm

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2

Swan, Elizabeth Joy. "Diabetic kidney disease : genome wide analyses for SNPs and methylation." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696325.

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Familial clustering of diabetic kidney disease (DKD) suggests the existence of a genetic predisposition towards the development of the disease. DKD continues to be the leading cause of end-stage renal disease (ESRD) worldwide. The identification of factors associated with a higher risk of DKD is an important scientific goal. Novel biomarkers associated with DKD may prove useful for the clinical prediction of DKD. At the beginning of this project the key research theme was to explore the genome-wide association study (GWAS) data generated by the GEnetics of Nephropathy, an International Effort

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Lienhard, Matthias [Verfasser]. "Computational Analysis of Genome-wide Methylation Enrichment Experiments / Matthias Lienhard." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1143596005/34.

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4

Guo, Cheng. "GENOME WIDE ANALYSES OF ALTERNATIVE POLYADENYLATION IN ARABIDOPSIS." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1479081485753738.

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5

Walker, Caroline Gwendolyn. "Genome-wide transcriptional and DNA methylation profiling of the bovine endometrium." Thesis, University of Auckland, 2012. http://hdl.handle.net/2292/19432.

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The aim of this research was to identify key molecular mechanisms regulating early pregnancy events in dairy cattle. Genome-wide gene expression and DNA methylation profiles were characterised in the endometrium of fertile and sub-fertile dairy cows at day 17 of pregnancy and the oestrous cycle. Gene expression data in combination with QTL data was then used to identify candidate genes for genetic analysis. The results of this study identified several biological processes likely to be important contributors to pregnancy success. In particular, genes classified as having roles in immune r

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6

Jiang, Ruiwei. "Genome-wide analysis of DNA methylation variance in healthy human subjects." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52977.

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DNA methylation is a type of epigenetic modification that modulates gene expression by acting as an intermediate between genes and environment; this in turn could trigger phenotypic changes with widespread implications in both disease and population models. Unlike DNA sequence, which is relatively stable and finite, DNA methylation presents itself differently in different tissues, and it is described as the sum of interactions affecting attachment of methyl groups to DNA mostly as a result of development and aging, with minor influences from stochastic variability, and environmental factors. M

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7

Price, Eva Magdalena Wagner. "DNA methylation in human development : methodologies and analytics for genome-wide studies." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57845.

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High-throughput methods have resulted in a large volume of studies measuring genome-wide DNA methylation (DNAm) in association with human health and disease. Understanding of DNAm patterns may be translated, for example, into predicting children at risk for illness or identifying etiological subtypes within a heterogeneous disease. Addressing biological and technical factors affecting measurement of genome-wide DNAm is essential to reduce false discovery in such studies. This dissertation develops principles for analyzing genome-wide DNAm, with the aim of improving collection and analysis of h

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Najgebauer, H. "Genome-wide DNA methylation and gene expression profiling of cancer-associated myofibroblasts." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001706/.

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In recent years it has become increasingly apparent that tumour development and metastasis are not simply driven by mutations within cancer cells. Factors produced by stromal myofibroblasts play a key role in the development and metastasis of many forms of cancer. However, our knowledge of the range of molecular mechanisms that drive paracrine communication between cancer and stromal cells remains incomplete. Evidence from previous studies show that myofibroblasts derived from gastric tumours (CAMs) not only retain their ability to enhance the proliferation and migration of cancer cells in vit

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9

Gerring, Zachary F. "Integrating genome-wide association and blood genomic profiling data to characterise migraine risk loci." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/112796/1/Zachary_Gerring_Thesis.pdf.

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This thesis involved a multi-staged integrated study of gene expression, DNA methylation, and DNA sequence variation data in a large sample of migraine cases and non-migraine controls. The analysis and integration of these data identified molecular perturbations associated with migraine, and prioritised migraine susceptibility genes for further functional characterisation. The use of multiple molecular data to study existing migraine loci has the potential to provide a substantial contribution to understanding the underlying genetic architecture and biological mechanisms of migraine, and may h

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10

Yeung, Kit-san, and 楊傑燊. "The use of genome-wide DNA methylation microarray to study both the common and rare diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207174.

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11

Oakes, Christopher Charles. "DNA methylation in male germ cells : the acquisition and maintenance of unique genome-wide patterns." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103175.

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The development of healthy gametes is paramount to the health of progeny and to the survival of a species. Epigenetic information contained within gametic DNA in the form of DNA methylation is essential for germ cell and embryo development. DNA methylation is a genome-wide phenomenon involved in the control of gene expression and chromosome structure and stability. During germ line development, patterns of DNA methylation are established in a sex- and sequence-specific manner. The primary goal of the work presented in this thesis is to gain an understanding of the nature of the genome-wide pat

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12

Braun, Patricia Rose. "Genome-wide DNA methylation investigation of stress: from a mouse model of chronic stress to humans exposed to glucocorticoids." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6373.

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Stress contributes to the development of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD), and an intermediary factor between stress and psychiatric disorders may be epigenetics. Studies have shown altered DNA methylation (DNAm) in animal models of and humans with stress exposure and in individuals with PTSD and MDD. The availability of genome-wide experimental platforms has given us new tools to investigate DNAm, and in this dissertation these techniques have been used to further our current understanding of the epigenetics of stress. We performed a genome-wide invest

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13

Salhab, Abdul Rahman [Verfasser], and Jörn [Akademischer Betreuer] Walter. "Genome-wide analysis of DNA methylation topology to understand cell fate / Abdul Rahman Salhab ; Betreuer: Jörn Walter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1213294436/34.

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14

Moreland, Blythe S. "Genome-wide studies of DNA and RNA with modifications through high-throughput sequencing analysis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153452875946939.

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15

Panda, Kaushik Kant. "Genome-Wide Regulation of Both Canonical and Non-canonical RNA-directed DNA Methylation Mechanisms in Arabidopsis thaliana." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512116266715136.

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Yang, Diya. "Genome-wide Analysis of F1 Hybrids to Determine the Initiation of Epigenetic Silencing in Maize." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1610098527086245.

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17

McCartney, Daniel Lawrence. "Investigating genome-wide transcriptional and methylomic consequences of a balanced t(1;11) translocation linked to major mental illness." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28873.

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Schizophrenia, bipolar disorder and major depressive disorder are devastating psychiatric conditions with a complex, overlapping genetic and environmental architecture. Previously, a family has been reported where a balanced chromosomal translocation between chromosomes 1 and 11 [t(1;11)] shows significant linkage to these disorders. This translocation transects three genes: Disrupted in schizophrenia- 1 (DISC1) on chromosome 1, a non-coding RNA, Disrupted in schizophrenia-2 (DISC2) antisense to DISC1, and a non-coding transcript, DISC1 fusion partner-1 (DISC1FP1) on chromosome 11, all of whic

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Stäble, Sina [Verfasser], and Odilia [Akademischer Betreuer] Popanda. "Deconvolution of Hematopoietic Commitment Decisions by Genome-wide Analysis of Progressive DNA Methylation Changes / Sina Stäble ; Betreuer: Odilia Popanda." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1201346495/34.

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Quintana, Kageyama Jorge Enrique [Verfasser], and Daniel [Akademischer Betreuer] Huson. "Genome-wide analysis of organ-specific DNA methylation patterns in Arabidopsis thaliana / Jorge Enrique Quintana Kageyama ; Betreuer: Daniel Huson." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1165235684/34.

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Kageyama, Jorge [Verfasser], and Daniel [Akademischer Betreuer] Huson. "Genome-wide analysis of organ-specific DNA methylation patterns in Arabidopsis thaliana / Jorge Enrique Quintana Kageyama ; Betreuer: Daniel Huson." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1165235684/34.

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Marchioretto, Lisa. "Development and validation of methods for genome-wide epigenetic analyses of human myogenic cells." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423853.

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Epigenetics is subjected to a pressing attention from the scientific community, because of its potential to explain the mechanisms of gene activation or repression. In this thesis I present a discovery-driven project aimed to the investigation of the epigenetic role in human myogenesis (and in particular the differentiation of myoblasts in myotubes). Studying epigenetics still presents significant hurdles, both experimental and computational. Therefore my first task was the establishment of robust protocols for investigating the role of epigenetics players during skeletal muscle differentiati

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Chalei, Vladislava. "Investigating molecular mechanisms of Dali, an intergenic chromatin-associated lincRNA regulating genes locally and neural differentiation genome-wide." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:9c296666-927c-4c53-b250-39e79643b0f8.

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Recently, long non-coding RNAs (lncRNAs) emerged as important regulators of many cellular functions. Many nuclear lncRNAs regulate the expression of geomically proximal or overlapping protein coding genes. Less clear is whether intergenic lncRNAs can regulate transcription by modulating chromatin at genomically distant loci in an RNA-dependent manner. This thesis investigated molecular functions of Dali, an intergenic central nervous system expressed lncRNA conserved in therian mammals. Dali is transcribed from a locus 50 kb downstream of the Pou3f3 transcription factor gene and performs both

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Kgatle, Mankgopo Magdeline. "An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/8800.

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Includes bibliographical references.<br>Hepatitis B virus (HBV) is oncogenic and a major cause of hepatocellular carcinoma (HCC) in the developing world. It integrates parts of its genome such as the HBx gene, core and surface antigens into the human genome. The integrated viral DNA disrupts gene function resulting in physiological changes that cause liver disease. The viral inserts are inactivated through methylation. This is a protective innate response driven by human DNA methyltransferases triggered by the presence of viral DNA inserts. This thesis investigates the hypothesis that during t

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Panni, Tommaso [Verfasser], and Annette [Akademischer Betreuer] Peters. "Impact of air pollution exposure on genome-wide DNA methylation and its association with socio-economic status / Tommaso Panni ; Betreuer: Annette Peters." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148941126/34.

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Shojaei, Saadi Habib Allah, and Saadi Habib Allah Shojaei. "Development and application of sensitive genome-wide platforms to study the genetic and epigenetic (DNA methylation) makeup of gametes and early bovine embryos." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27012.

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Pour ce projet, nous avons développé une plateforme pour l’analyse pangénomique de la méthylation de l’ADN chez le bovin qui est compatible avec des échantillons de petites tailles. Cet outil est utilisé pour étudier les caractéristiques génétiques et épigénétiques (méthylation de l'ADN) des gamètes soumis aux procédures de procréation médicalement assisitée et des embryons précoces. Dans un premier temps, une plateforme d’analyse de biopuces spécifiques pour l’étude de la méthylation de l’ADN chez l’espèce bovine a été développée. Cette plateforme a ensuite été optimisée pour produire des ana

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Zeilinger, Sonja [Verfasser], Jerzy [Akademischer Betreuer] Adamski, Thomas [Akademischer Betreuer] Illig, and Hans-Rudolf [Akademischer Betreuer] Fries. "Association analysis between genome-wide DNA methylation patterns and tobacco smoking / Sonja Zeilinger. Gutachter: Thomas Illig ; Jerzy Adamski ; Hans-Rudolf Fries. Betreuer: Jerzy Adamski." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1048677311/34.

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Jeschke, Jana [Verfasser], and Andreas [Akademischer Betreuer] Winterpacht. "Utilization of Genome-wide DNA Methylation Changes in Breast Cancer for Identification of Biomarkers for Prognosis and Mechanisms of Tumorigenesis / Jana Jeschke. Betreuer: Andreas Winterpacht." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1033029882/34.

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Bazzocco, Sarah. "Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/350805.

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Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes and oncogenes is far from complete, even in the case of the tumor types that are best characterized, such as colorectal cancer. Colorectal cancer is the second most frequent cause of cancer-related death in the Western world and is a serious health issue for the European Union. Patients having stage III or IV cancer undergo surgery followed by chemotherapy. However, the cli

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Pishva, Seyyed Reza. "Investigation of hypertension susceptibility markers in the Norfolk Island population isolate and an Australian hypertensive-normotensive cohort." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122225/1/Seyyed%20Reza_Pishva_Thesis.pdf.

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This thesis utilised the unique Norfolk Island (NI) genetic isolate population and an Australian hypertensive-normotensive (HT-NT) cohort to identify hypertension susceptibility markers. Specifically, an Australian HT-NT population was used for a genetic replication study to validate findings for candidate single nucleotide polymorphisms (SNPs) identified from a Genome-Wide Association Study of NI HT-NT samples. Additionally, epigenetic modifications in regulatory regions of candidate genes were explored to determine the potential impact of DNA methylation in hypertension. The results of this

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UDALI, SILVIA. "Genome-wide DNA methylation profiles by high-throughput techniques in alcohol-related hepatocellular carcinoma: identification of epigenetic signatures in liver tissue and peripheral blood cells DNA as potentially useful biomarkers of disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41782.

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DNA methylation is the major epigenetic feature of eukaryotic cell DNA and consists in the covalent binding of a methyl group to the 5’ carbon of a cytosine in a CpG dinucleotide sequence and acts regulating gene expression. Methyl-transfer reactions occur within one-carbon metabolism pathway that takes place principally in the liver: hepatic tissue that is, therefore, to be considered among the most interesting target tissues for DNA methylation analysis. Moreover alcohol, a major risk factor for hepatic cancer, is known to disturb one-carbon metabolism but the mechanisms underlying the alcoh

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Pfeiffer, Liliane [Verfasser], Jerzy [Akademischer Betreuer] Adamski, Heiko [Gutachter] Witt, and Jerzy [Gutachter] Adamski. "Genome-wide DNA methylation analyses of human blood lipid levels and functional analyses of lipid-associated CpG sites / Liliane Pfeiffer ; Gutachter: Heiko Witt, Jerzy Adamski ; Betreuer: Jerzy Adamski." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1152006355/34.

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Hardy, Lise. "Identification de nouveaux acteurs du métabolisme des HDL : impact sur les maladies cardiovasculaires Critical role of the human ATP-binding cassette G1 transporter in cardiometabolic diseases A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS546.

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De faibles concentrations de cholestérol associé aux HDL (HDL-C) est un facteur de risque indépendant des maladies cardiovasculaires (MCV). Les HDL sont capables de réaliser de l’efflux de lipides des tissus périphériques pour assurer son retour vers le foie, et ont des rôles athéroprotecteurs. Le travail mené ici vise à identifier de nouveaux acteurs impliqués dans la détermination des fonctions des HDL. Le transporteur ABCG1 réalise de l’efflux de cholestérol, de phospholipides (PL), ou encore de vitamines à partir des macrophages périphériques vers les HDL. Nous avons montré que la stimulat

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Voisin, Sarah. "Bioinformatic and Biostatistic Analysis of Epigenetic Data from Humans and Mice in the Context of Obesity and its Complications." Doctoral thesis, Paris 6, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300751.

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Worldwide obesity has more than doubled since 1980 and at least 2.8 million people die each year as a result of being overweight or obese. An elevated body weight is the result of the interplay between susceptibility gene variants and an obesogenic environment, and recent evidence shows that epigenetic processes are likely involved. The growing availability of high-throughput technologies has made it possible to assess quickly the entire epigenome of large samples at a relatively low cost. As a result, vast amounts of data have been generated and researchers are now confronted to both bioinfor

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Su, Sheng-Yao, and 蘇聖堯. "An Integrated Framework for Genome-wide DNA Methylation Profiling." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5h7frq.

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博士<br>國立陽明大學<br>生物醫學資訊研究所<br>107<br>DNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Using whole genome bisulfite sequencing (WGBS) technology, the methylated cytosine sites can be revealed at single nucleotide level. However, the WGBS data analysis process is usually complicated and challenging. To alleviate the associated difficulties, we integrated the data processing steps and downstream analysis into a two-phase app

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Pedersen, J. S., E. Valen, A. M. V. Velazquez, et al. "Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome." 2014. http://hdl.handle.net/10454/7060.

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yes<br>Epigenetic information is available from contemporary organisms, but is difficult to track back in evolutionary time. Here, we show that genome-wide epigenetic information can be gathered directly from next-generation sequence reads of DNA isolated from ancient remains. Using the genome sequence data generated from hair shafts of a 4000-yr-old Paleo- Eskimo belonging to the Saqqaq culture, we generate the first ancient nucleosome map coupled with a genome-wide survey of cytosine methylation levels. The validity of both nucleosome map and methylation levels were confirmed by the rec

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Tor, Moron Dalla. "GENOME-WIDE DNA METHYLATION PROFILING OF OBESE INSULIN RESISTANT CHILDREN." Doctoral thesis, 2021. http://hdl.handle.net/11562/1045548.

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Introduzione: L’insulino resistenza si presenta quando la risposta delle cellule all’insulina è diminuita causando un drammatico innalzamento dei livelli di zucchero nel sangue. I diversi fattori di rischio per l’insulino resistenza includono uno stile di vita sedentario, obesità, storia familiare di diabete e invecchiamento. Negli ultimi anni, il diabete di tipo 2, l’insulino resistenza e l’obesità sono considerevolmente aumentate nella popolazione contribuendo all’incremento in morbidità e mortalità nel mondo. I molti meccanismi proposti per spiegare il funzionamento dell’insulino resistenza

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Garvilles, Ronald-Garingalao, and 蓋羅納. "Genome-wide methylation pattern search in Prader-Willi Syndrome (PWS) patients." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/59827189279715437068.

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碩士<br>中原大學<br>生物科技研究所<br>99<br>Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by lack of functional paternal copy of 15q11-q13. Epigenetic aberrations due to genomic imprinting defect leads to the absence expression of paternally-inherited genes. This study aims to provide an overview of the methylation status of the whole-genome among PWS patients. A novel method PCR Selective Suppression Hybridization (PSSH) was employed to screen the putative genes that are differentially methylated among PWS patients but not in normal individuals. This method utilizes hybridization of

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Hsu, Chia-Hsin, and 許嘉心. "Genome-wide DNA Methylation Analysis Using MethylCap-seq in Canine Lymphoma." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/gebeu9.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>107<br>Canine high-grade B-cell lymphoma (cHGBL) is the most common lymphoma subtype occurring in dogs accepted as a comparative model of the human disease. Despite being a chemo-responsive tumor, this disease remains incurable due to the high relapse rates and subsequent chemoresistance. DNA methylation is one of the most intensely studied epigenetic modifications and plays crucial roles in cancer development. It is well known hypermethylation in promoters can result in inactivation of certain tumor suppressor genes. On the other hand, apart from altering DNA methyla

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Sobolev, Martha. "Inter-individual variations in genome-wide DNA methylation patterns in the human germline." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442223&T=F.

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Chang, Jer-Wei, and 張哲維. "Genome-Wide Methylation Profiling and Candidate Gene Methylation Spectrum in Lung Cancer: In Relation to Gene Expression and Clinical Significance." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/44973150880579843617.

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博士<br>國立臺灣師範大學<br>生命科學研究所<br>97<br>Cancer is caused by the accumulation of both genetic and epigenetic changes. Promoter hypermethylation is one of the major epigenetic changes that cause gene inactivation. Aberrant promoter hypermethylation of CpG islands associated with tumor suppressor genes (TSGs) can lead to transcriptional silencing and result in tumorigenesis. The genomic regions with hypermethylation status may possess novel candidate TSGs. The present study used a microarray-based epigenome-wide methylation analysis called differential methylation hybridization (DMH) to identify the r

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Gebhard, Claudia [Verfasser]. "Genome-wide analysis of aberrant CpG island methylation in human tumors / vorgelegt von Claudia Gebhard." 2010. http://d-nb.info/1005121400/34.

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Meissner, Alexander [Verfasser]. "Conditional RNA interference, altered nuclear transfer and genome-wide DNA methylation analysis / eingereicht von Alexander Meissner." 2006. http://d-nb.info/980572681/34.

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Yang, Wen-Ho, and 楊文和. "The DOP-PCR Specific for Genome-wide Amplification of Bisulfite-modified DNA and Analysis of Methylation Profiling." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/41644269874972347804.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>95<br>Mammalian DNA methylation is an epigenetic process involving in transcriptional gene silencing, suppression of transposable elements and chromatin structure modulation. Aberrant methylation of CpG-rich promoter regions has been found in many human cancers. Methylation profiling also poses an important topic for study of embryonic stem cell and somatic cell cloning. The current method for methylation status analysis relies on bisulfite treatment of genomic DNA, followed by methylation-specific PCR (MSP). The difficulty for acquiring a methylation profiling is

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Conceição, Carolina Neves. "Differential DNA methylation in aging: in silico exploration using high-throughput datasets." Master's thesis, 2018. http://hdl.handle.net/10773/24223.

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The emergence of high-throughput methodologies after the conclusion of the Human Genome Project has brought genomic and epigenomic wide studies to the forefront of current research of biological and biomedical knowledge. Currently, the focus in genetic mutations as primary cause of certain disorders is not so relevant as before, since it was demonstrated that epigenetic mechanisms are involved in cellular programming and gene regulation providing adaptive variants of a given gene to a changing environment with an association to cellular differentiation. The research in the DNA methylation fie

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Frederick, Armina-Lyn. "Impact of Bodyweight on Tissue-Specific Folate Status, Genome Wide and Gene-Specific DNA Methylation in Normal Breast Tissues from Premenopausal Women." 2018. https://scholarworks.umass.edu/masters_theses_2/639.

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Obesity has reached an epidemic level in the United States. A number of epidemiological studies have established obesity as a critical risk factor for postmenopausal breast cancer (post-BC), whereas a reverse association holds prior to menopause. A significant scientific gap exists in understanding the mechanism(s) underpinning this epidemiological phenomenon, particularly the reverse association between obesity and premenopausal breast cancer (pre-BC). This study aimed to understand how folate metabolism and DNA methylation informs the association between obesity and pre-BC. Fifty normal brea

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Hung, Wan-Yu, and 洪宛榆. "Identification of Genome-wide DNA Methylation Alterations in Colorectal Tumors and Its Application in Early Detection of Cell-free DNA of Plasma." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9n6db3.

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Acharya, Chaitanya Ramanuj. "Efficient analysis of complex, multimodal genomic data." Diss., 2016. http://hdl.handle.net/10161/13390.

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Abstract:

<p>Our primary goal is to better understand complex diseases using statistically disciplined approaches. As multi-modal data is streaming out of consortium projects like Genotype-Tissue Expression (GTEx) project, which aims at collecting samples from various tissue sites in order to understand tissue-specific gene regulation, new approaches are needed that can efficiently model groups of data with minimal loss of power. For example, GTEx project delivers RNA-Seq, Microarray gene expression and genotype data (SNP Arrays) from a vast number of tissues in a given individual subject. In order to a

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