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Relevant bibliographies by topics / Genomic chemistry

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Academic literature on the topic 'Genomic chemistry'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Genomic chemistry"

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OIKAWA, Hideaki. "Chemistry Based on Genomic Resources." TRENDS IN THE SCIENCES 16, no. 5 (2011): 66–69. http://dx.doi.org/10.5363/tits.16.5_66.

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Whitley, Kiara V., Josie A. Tueller, and K. Scott Weber. "Genomics Education in the Era of Personal Genomics: Academic, Professional, and Public Considerations." International Journal of Molecular Sciences 21, no. 3 (2020): 768. http://dx.doi.org/10.3390/ijms21030768.

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Since the completion of the Human Genome Project in 2003, genomic sequencing has become a prominent tool used by diverse disciplines in modern science. In the past 20 years, the cost of genomic sequencing has decreased exponentially, making it affordable and accessible. Bioinformatic and biological studies have produced significant scientific breakthroughs using the wealth of genomic information now available. Alongside the scientific benefit of genomics, companies offer direct-to-consumer genetic testing which provide health, trait, and ancestry information to the public. A key area that must

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Bertini, Ivano, and Antonio Rosato. "A Genomic Frontier in Bioinorganic Chemistry." Chemistry Letters 33, no. 8 (2004): 946–51. http://dx.doi.org/10.1246/cl.2004.946.

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Darvas, Ferenc, Gyorgy Dorman, Laszlo Urge, Istvan Szabo, Zsolt Ronai, and Maria Sasvari-Szekely. "Combinatorial chemistry. Facing the challenge of chemical genomics." Pure and Applied Chemistry 73, no. 9 (2001): 1487–98. http://dx.doi.org/10.1351/pac200173091487.

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In the age of high-throughput screening and combinatorial chemistry, the focus of drug discovery is to replace the sequential approach with the most effective parallel approach. By the completion of the human gene-map, understanding and healing a disease require the integration of genomics, proteomics, and, very recently, metabolomics with early utilization of diverse small-molecule libraries to create a more powerful "total" drug discovery approach.In this post-genomic era, there is an enhanced demand for information-enriched combinatorial libraries which are high-quality, chemically and phys

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Hayatsu, H., K. Negishi, M. Shiraishi, K. Tsuji, and K. Moriyama. "Chemistry of Bisulfite Genomic Sequencing; Advances and Issues." Nucleic Acids Symposium Series 51, no. 1 (2007): 47–48. http://dx.doi.org/10.1093/nass/nrm024.

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Gim, Jeong-An. "A Genomic Information Management System for Maintaining Healthy Genomic States and Application of Genomic Big Data in Clinical Research." International Journal of Molecular Sciences 23, no. 11 (2022): 5963. http://dx.doi.org/10.3390/ijms23115963.

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Improvements in next-generation sequencing (NGS) technology and computer systems have enabled personalized therapies based on genomic information. Recently, health management strategies using genomics and big data have been developed for application in medicine and public health science. In this review, I first discuss the development of a genomic information management system (GIMS) to maintain a highly detailed health record and detect diseases by collecting the genomic information of one individual over time. Maintaining a health record and detecting abnormal genomic states are important; t

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Yue, Tianwei, Yuanxin Wang, Longxiang Zhang, et al. "Deep Learning for Genomics: From Early Neural Nets to Modern Large Language Models." International Journal of Molecular Sciences 24, no. 21 (2023): 15858. http://dx.doi.org/10.3390/ijms242115858.

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The data explosion driven by advancements in genomic research, such as high-throughput sequencing techniques, is constantly challenging conventional methods used in genomics. In parallel with the urgent demand for robust algorithms, deep learning has succeeded in various fields such as vision, speech, and text processing. Yet genomics entails unique challenges to deep learning, since we expect a superhuman intelligence that explores beyond our knowledge to interpret the genome from deep learning. A powerful deep learning model should rely on the insightful utilization of task-specific knowledg

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Miedaner, Thomas, Ana Luisa Galiano-Carneiro Boeven, David Sewodor Gaikpa, Maria Belén Kistner, and Cathérine Pauline Grote. "Genomics-Assisted Breeding for Quantitative Disease Resistances in Small-Grain Cereals and Maize." International Journal of Molecular Sciences 21, no. 24 (2020): 9717. http://dx.doi.org/10.3390/ijms21249717.

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Generating genomics-driven knowledge opens a way to accelerate the resistance breeding process by family or population mapping and genomic selection. Important prerequisites are large populations that are genomically analyzed by medium- to high-density marker arrays and extensive phenotyping across locations and years of the same populations. The latter is important to train a genomic model that is used to predict genomic estimated breeding values of phenotypically untested genotypes. After reviewing the specific features of quantitative resistances and the basic genomic techniques, the possib

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Burd, Gary. "Post-Genomic Partnership for Chemistry and Biology: 16 November 2001." Biochemist 24, no. 1 (2002): 33–34. http://dx.doi.org/10.1042/bio02401033.

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Biology and Chemistry Departments have traditionally occupied separate buildings on campus -- at one time in the not too distant past, few universities managed to encourage mingling. A one-day symposium, organized by the UKLSC and RSC, aimed to address some of the issues involved in convincing biologists that chemistry is invaluable, and vice versa. The presentations demonstrated how a mixture of disciplines can achieve impressive results in the new post-genomic proteomic era.

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Varfolomeyev, S. D., T. K. Aliev, and E. N. Efremenko. "Postgenomic chemistry: New problems and challenges." Pure and Applied Chemistry 76, no. 9 (2004): 1781–98. http://dx.doi.org/10.1351/pac200476091781.

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New trends in chemistry induced by genetic engineering and genomic information are analyzed. Genomic information and bioinformatics make the identification of all molecular participants of biological processes possible. The methods of identification of enzyme-active sites from sequence data were demonstrated. The problems of "chemical proteomics" were formulated and analyzed. New biocatalytic processes based on a new generation of enzymes, including CO2 reduction and enzyme fuel cell construction, are demonstrated. It was shown that in many reactions the enzymes are substantially more efficien

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Dissertations / Theses on the topic "Genomic chemistry"

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Angell, Scott Edward. "Genomic and metagenomic approaches to natural product chemistry." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2671.

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Neeley, William Louis. "Genomic consequences of DNA oxidation by peroxynitrite." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37359.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Vita.<br>Includes bibliographical references.<br>The radicals nitric oxide and superoxide are produced endogenously by activated macrophages and neutrophils and combine in a diffusion-limited reaction to form peroxynitrite, a powerful oxidizing and nitrating agent capable of damaging a variety of biomolecules, including DNA. Of the four nucleobases of DNA, guanin

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Liu, Yubing. "Genomic characterization of Six1 function during skeletal muscle differentiation." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28705.

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The Six family of transcription factors counts six members in vertebrates (from Six1 to Six6). Six1 is important for skeletal muscle development: Six1-/- mouse neonates die at birth because of severe muscle hypoplasia. However, the molecular targets of Six1 are poorly characterized systematically. The Myogenic Regulatory Factors (MRFs) are critical transcription factors in skeletal muscle development, and comprise MyoD, Myf5, Myogenin and Myf6. Based on previous bioinformatics predictions, it was proposed that Six1 had a genome-wide function and cooperated with MRFs by co-regulating gene expr

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Laganière, Josée. "Identification of functional genomic targets of ER [alpha] and ERR [alpha]." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111852.

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The biological activity of estrogens is mediated by estrogen receptors (ERs), members of the superfamily of nuclear receptors. ERs modulate gene transcription through binding to estrogen response elements (EREs) within regulatory regions of their target genes followed by recruitment of coregulator complexes that modify the chromatin structure and allow general transcription factors to activate transcription. The estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan receptors that share sequence similarity with the ERs but are not activated by natural estrogens.<br>ERalpha is a ma

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Paoletti, Andrew Borer Philip N. "Affinity of the HIV-1 nucleocapsid protein for structural motifs in the genomic RNA packaging domain." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2004. http://wwwlib.umi.com/cr/syr/main.

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Liu, Yiding. "Technologies for Proteomic and Genomic Biomarker Analysis." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1229461302.

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Chung, Janet. "Investigation of small molecule - SL1 RNA interactions and implications in drug design targeted at HIV-1 genomic dimer maturation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390040.

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Zacharioudakis, Emmanouil. "Unbiased discovery of druggable genomic targets by Click-sequencing (Click-seq)." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS234.

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Durant ma thèse, mes études ont été axées sur le développement de nouvelles sondes et des protocoles chimiques pour l'élucidation des mécanismes d'action et de résistance pour les trois médicaments anticancéreux (cisplatine, le vorinostat, topotécan). L'idée de sondes chimiques qui peuvent être étiquetés post-traitement in cellulo avec des fluorophores par exemple Alexa Fluor 488 ou affinité des fragments par exemple biotine, nous a fasciné pour effectuer petite visualisation de molécule par microscopie confocale, ou pour développer des protocoles tirer vers le bas pour les petites cibles molé

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Nyberg, Kara Ann. "Analysis of RAD9 functions: Roles in the checkpoint response, DNA damage processing, and prevention of genomic instability." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280312.

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In the 15 years since Rad9's discovery, we have come to understand a great about Rad9 biology, yet numerous questions still remain. Especially intriguing questions include: (a) How does Rad9 get localized and/or recognize DNA damage? (b) How does Rad9 activate downstream checkpoint proteins? and (c) Does Rad9 play additional roles in recognizing and/or repairing DNA damage that have yet to be discovered? In an effort to try to answer some of these questions, I analyzed the effects of various RAD9 mutations. To assess the contribution of RAD9 to inhibiting DNA degradation and its role in the c

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de, La Harpe Kimberly Desneiges. "Femtosecond UV and Infrared Time-Resolved Spectroscopy of DNA: From Well-ordered Sequences to Genomic DNA." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299527926.

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Books on the topic "Genomic chemistry"

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1965-, Huang Ziwei, ed. Drug discovery research: New frontiers in the post-genomic era. John Wiley & Sons, 2007.

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Phytochemical Society of North America. Meeting. Phytochemistry in the genomics and post-genomics eras. Pergamon, 2002.

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F, Darvas, Guttman András, and Dormán G, eds. Chemical genomics. Marcel Dekker, 2004.

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Lister, Ted. Chemistry and the human genome. Royal Society of Chemistry, 2002.

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Morton, Bradbury E., Pongor Sándor, and NATO Advanced Research Workshop on Structural Biology and Functional Genomics (1998 : Trieste, Italy), eds. Structural biology and functional genomics. Kluwer, 1999.

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Anil, Sehgal. Chemical genomics: Commercial applications in drug discovery and development. D&MD Publications, 2004.

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Schnell, R. J. Genomics of Tree Crops. Springer New York, 2012.

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P, Starkey Michael, and Elaswarapu Ramnath, eds. Genomics protocols. Humana Press, 2001.

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R, Pennington S., and Dunn M. J, eds. Proteomics: From protein sequence to function. BIOS, 2001.

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Grandbastien, Marie-Angèle. Plant Transposable Elements: Impact on Genome Structure and Function. Springer Berlin Heidelberg, 2012.

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Book chapters on the topic "Genomic chemistry"

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Hewitt, Philip, and Esther Johann. "Genomic Applications for Assessing Toxicities of Liver and Kidney Injury." In Methods and Principles in Medicinal Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527674183.ch05.

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Djordjevic, Steven P., Veronica M. Jarocki, Branwen Morgan, and Erica Donner. "Genomic Surveillance for One Health Antimicrobial Resistance: Understanding Human, Animal, and Environmental Reservoirs and Transmission." In The Handbook of Environmental Chemistry. Springer International Publishing, 2020. http://dx.doi.org/10.1007/698_2020_626.

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Bombaywala, Sakina, Sanchita Das, Jemi Gandhi, et al. "Chapter 3. Understanding the Emergence and Mobility of Antibiotic Resistance in a Wastewater Microbiome Using an Advanced Genomic Approach and Advanced Photochemical Water Treatment." In Chemistry in the Environment. Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781839167355-00060.

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Weber, Lutz. "Chemistry for Chemical Genomics." In Methods in Molecular Biology™. Humana Press, 2005. http://dx.doi.org/10.1007/978-1-59259-948-6_2.

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Shively, John E. "The chemistry of protein sequence analysis." In Proteomics in Functional Genomics. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8458-7_7.

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Roepstorff, Peter. "MALDI-TOF mass spectrometry in protein chemistry." In Proteomics in Functional Genomics. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8458-7_6.

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Wong, Yung-Sing. "Exploring Chemical Space: Recent Advances in Chemistry." In Chemical Genomics and Proteomics. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-349-3_2.

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Niamké, Florence Bobelé, Nadine Amusant, Adima Amissa Augustin, and Gilles Chaix. "Teakwood Chemistry and Natural Durability." In Compendium of Plant Genomes. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79311-1_7.

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Griffiths, William J. "Nanospray mass spectrometry in protein and peptide chemistry." In Proteomics in Functional Genomics. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8458-7_5.

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Ravikumar, Puja, and R. K. Singh. "Genome Enabled Technologies in Green Chemistry." In Green Chemistry for Environmental Remediation. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118287705.ch19.

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Conference papers on the topic "Genomic chemistry"

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Teevens, Patrick J., and Shubhashalini Vincent. "Hydrofracking and Internal Corrosion Problems Identification and Confirmation in Shale Oil and Gas Production." In CONFERENCE 2025. AMPP, 2025. https://doi.org/10.5006/c2025-00251.

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Abstract Large volumes of fresh water when used for fracking of hydrocarbon producing horizons in oil and gas operations, unexpectedly comes with a heavy price tag with operational and safety implications. This paper identifies the essential on-site and laboratory testing protocols required to confirm both the extent and breadth of the array of internal corrosion drivers created downhole and transported to surface production pipelines in shale formations. Companion samples, when collected simultaneously and then subsequently site and lab tested for water chemistries, petrographic analysis (i.e

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VAN DER DONK, WILFRED A. "NATURAL PRODUCT BIOSYNTHESIS IN THE GENOMIC AGE." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0002.

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Romero-López, Cristina, Alfredo Berzal-Herranz, and Cristina Fernández-Molina. "Highly Conserved WNV Genomic RNA Domains are Potential Targets of Antiviral RNA Aptamers." In 2nd International Electronic Conference on Medicinal Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a009.

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Romero-López, Cristina, Alfredo Berzal-Herranz, Sara Ramos-Lorente, and Isabel Pérez-Jover. "The 3’UTR of the West Nile Virus genomic RNA is a potential antiviral target site." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06281.

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Martin, Yvonne. "The role of computational chemistry in translating genomic information into bioactive small molecules (abstract only)." In the fifth annual international conference. ACM Press, 2001. http://dx.doi.org/10.1145/369133.369217.

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Mladenović, Milan P., Nevena M. Tomašević, Sanja Lj Matić, Tamara M. Mladenović, and Rino Ragno. "Computer-aided design of new drugs against breast cancer." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.641m.

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Computational medicinal chemistry, if used properly and in accordance with the available experimental data, may provide significant support to rational drug design. Herein, an overview of the computational approaches that have been applied to an estrogen receptor α (ERα) and endowed in the rational design of pM ERα antagonists with profound anti-breast cancer activity either in vitro or in vivo, will be presented. ERα is a 17β-estradiol inducible transcriptional regulator that initiates the RNA polymerase II-dependent transcriptional machinery, pointed for breast cancer (BC) development via ei

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De Paula, Renato, Chris Jones, Charles Armstrong, et al. "Simulative Studies on the Control of Biofouling and Microbial Souring in the Wellbore of Injection Wells." In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213792-ms.

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Abstract This study evaluates the strategies to control microorganisms in the near wellbore area of water injection wells during secondary oil recovery. Biomass accumulation in the water injection wells can increase injection pressure and generate H2S. Nitrate injections can often overstimulate nitrate-reducer’s growth, increasing biofouling and souring downhole. Thus, control of microbes near wellbore must include the concomitant control of SRB activity and the reduction of the total microbial population. We evaluated strategies to reduce biofouling, increase injection flow and decrease H2S i

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Carell, Thomas. "The chemistry of genome maintenance." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112001.

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Sadler, J. Evan. "THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643930.

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Human von Willebrand factor (vWF) is a plasma glycoprotein that is synthesized by endothelial cells and megakaryocytes, and perhaps by syncytiotrophoblast of placenta. The biosynthesis of vWF is very complex, involving proteolytic processing, glycosyla-tion, disulfide bond formation, and sulfation. Mature vWF consists of a single subunit of ∼ 250,000 daltons that is assembled into multimer ranging from dimers to species of over 10 million daltons. vWF performs its essential hemostatic function through several binding interactions, forming a bridge between specific receptors on the platelet sur

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DAWSON, NATALIE L., ROMAIN STUDER, NICK FURNHAM, et al. "WHAT CAN COMPARATIVE GENOMICS REVEAL ABOUT THE MECHANISMS OF PROTEIN FUNCTION EVOLUTION?" In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0004.

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Reports on the topic "Genomic chemistry"

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Wang, X. F., and M. Schuldiner. Systems biology approaches to dissect virus-host interactions to develop crops with broad-spectrum virus resistance. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134163.bard.

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More than 60% of plant viruses are positive-strand RNA viruses that cause billion-dollar losses annually and pose a major threat to stable agricultural production, including cucumber mosaic virus (CMV) that infects numerous vegetables and ornamental trees. A highly conserved feature among these viruses is that they form viral replication complexes (VRCs) to multiply their genomes by hijacking host proteins and remodeling host intracellular membranes. As a conserved and indispensable process, VRC assembly also represents an excellent target for the development of antiviral strategies that can b

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