Relevant bibliographies by topics / Genotyp

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Genotyp'

Author: Grafiati
Published: 4 June 2021
Last updated: 24 January 2023

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Journal articles on the topic "Genotyp"

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Telser, Müllhaupt, Helbling, and Zweifel. "Kostenvergleich zwischen zwei Kombinationstherapien gegen Hepatitis C mit pegylierten Interferonen und Ribavirin." Praxis 94, no. 32 (August 1, 2005): 1207–14. http://dx.doi.org/10.1024/0369-8394.94.32.1207.

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Die Wirksamkeit und Sicherheit der beiden in der Schweiz zur Behandlung der Hepatitis C zugelassenen Kombinationstherapien (Pegasys®/Copegus®, PAC; PegIntron®/Rebetol®, PIR) ist sehr ähnlich. Das Ziel dieser Arbeit ist, die Kosten der beiden Therapien zu vergleichen und ihren kostengünstigsten Einsatz zu definieren. Die Durchschnittskosten für Genotyp-1-Patienten liegen zwischen CHF 21700.– (PAC) und CHF 19700.– (PIR), bzw. CHF 15600.– (PAC) und CHF 15000.– (PIR) für Genotyp-2/3-Patienten. Ein konsequenter Einsatz von PIR ist 9 bis 12% kostengünstiger als PAC. Weitere Kosteneinsparungen von 3% könnten bei einem Einsatz von PIR bei allen Patienten unter 85 kg (Genotyp 1) bzw. unter 75 kg (Genotyp 2/3) und von PAC bei solchen über 85 kg (Genotyp 1) bzw. über 75 kg (Genotyp 2/3) erreicht werden.
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Messa, P., C. Sindici, B. Brezzi, A. Aroldi, E. Rusconi, and B. Gallelli. "Genotyp und sekundärer Hyperparathyreoidismus." Nieren- und Hochdruckkrankheiten 34, no. 05 (May 1, 2005): 209–15. http://dx.doi.org/10.5414/nhp34209.

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Hiort, O. "Vom Genotyp zum Phänotyp." Monatsschrift Kinderheilkunde 146, no. 2 (February 26, 1998): 86–91. http://dx.doi.org/10.1007/s001120050248.

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Hiller, Michael. "Vom Phänotyp zum Genotyp." Biologie in unserer Zeit 43, no. 1 (February 2013): 34–39. http://dx.doi.org/10.1002/biuz.201310498.

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Augustin, Marc. "Was verrät der CYP2C19-Genotyp?" InFo Neurologie & Psychiatrie 21, no. 4 (April 2019): 27. http://dx.doi.org/10.1007/s15005-019-0059-5.

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Eisenhardt, A., A. Scherag, M. Kempin, K. H. Jöckel, and H. Rübben. "Genotyp des GNB3-C825T-Polymorphismus." Der Urologe 50, no. 9 (July 8, 2011): 1137–42. http://dx.doi.org/10.1007/s00120-011-2621-8.

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Simon, Karl-Georg, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Klaus H. W. Boeker, Hartwig Klinker, Tobias Müller, et al. "Veränderungen der Hepatitis-C-Virus-Genotyp-1a/1b-Verteilung zwischen 2004 und 2018 in Deutschland – eine Analyse von 17093 Patienten aus verschiedenen Real-World-Registern." Zeitschrift für Gastroenterologie 59, no. 03 (March 2021): 241–49. http://dx.doi.org/10.1055/a-1332-2214.

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Zusammenfassung Einleitung Der Hepatitis C Genotyp 1 ist der häufigste Genotyp in West- und Zentraleuropa. In dieser Arbeit werden die Veränderungen der Baselinecharakteristika von 17 093 HCV-Patienten mit Genotyp 1a/1b, die im Zeitraum 2004–2018 in Deutschland antiviral therapiert wurden, analysiert. Es wurden insgesamt 5 Zeiträume betrachtet: (i) 2004–2007, (ii) 2008–2010, (iii) 2010–2013, (iv) 2014–2016, (v) 2017–2018. Methoden Die vorliegende Analyse basiert auf 5 deutschlandweit durchgeführten nicht-interventionellen Registern und umfasst Daten von Patienten, die mit dem HCV-GT1a und HCV-GT1b infiziert waren und zwischen 2004 und 2018 dokumentiert wurden [ML17071, ML19464, ML21645, ML25724 (Peginterferon alfa-2a® non-interventional study (PAN)) und dem Deutschen Hepatitis-C-Register (DHC-R)]. Ergebnisse Im Untersuchungszeitraum (2004–2018) hatten 7662 Patienten eine HCV-GT1a- und 9431 Patienten eine HCV-GT-1b-Infektion. GT1a-Patienten waren im Vergleich zu GT1b-Patienten jünger (46,5 Jahre vs. 51,2 Jahre) und häufiger männlich (70 % vs. 52 %). Drogenkonsum in der Vorgeschichte oder derzeit war im Untersuchungszeitraum häufiger bei GT1a-Patienten mit höchster Frequenz im aktuellsten Zeitraum (2017–2018; 44 % GT1a, 10 % GT1b). Metabolische Komorbiditäten wie Übergewicht und Diabetes mellitus waren häufiger bei mit GT1b infizierten Frauen. Der Anteil des Genotyps 1a nahm von 34 % (Zeitraum 2004–2007) auf ca. 50 % (Zeitraum 2017–2018) relevant zu. 2004–2018 zeigte sich ein relevanter Wechsel des GT1a/1b-Quotienten bei Männern (2004–2007: 38 %/63 %; 2017–2018: 59 %/41 %) bei weitgehend konstantem GT1a-Anteil der Frauen von ca. 30 % deutschlandweit über alle 5 untersuchten Zeiträume.Der Anteil der weiblichen Patienten mit GT1a in der Region Ost war im Vergleich zu den anderen 3 Regionen über nahezu alle Zeiträume niedriger, am deutlichsten ausgeprägt 2004–2007: 14 % GT1a vs. 86 % GT1b. Zusammenfassung Im untersuchten Zeitraum (2004–2018) zeigte sich ein relevanter Anstieg der Genotyp-1a-Infektion bei Männern, nicht bei Frauen, assoziiert mit Drogenkonsum. Die Daten zeigen eine grundlegende Änderung in der HCV-Epidemiologie in Deutschland an, die Konsequenzen für das Therapiemanagement und die allgemeine Versorgung der Hepatitis-C-Patienten haben.
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Cichocka, Barbara. "Czy bliźnięta jednojajowe mają identyczny genotyp?" Anthropological Review 58 (December 30, 1995): 33–41. http://dx.doi.org/10.18778/1898-6773.58.04.

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Heinrich-Weltzien, Roswitha, Stefanie Baum, Sabine Bertzbach, Jörn Erlecke, and Julia Hentschel. "Amelogenesis imperfecta — Eine Genotyp-Phänotyp-Studie." Oralprophylaxe & Kinderzahnheilkunde 38, no. 3 (September 2016): 112. http://dx.doi.org/10.3238/opkzh.2016.0112-0119.

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Schuster, Herbert, Sylvia Bähring, Thomas Wienker, and Friedrich Luft. "Die Reise vom Phänotyp zum Genotyp." DMW - Deutsche Medizinische Wochenschrift 140, no. 25 (December 16, 2015): 1920–23. http://dx.doi.org/10.1055/s-0041-107586.

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Dissertations / Theses on the topic "Genotyp"

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Roshyara, Nab Raj, Katrin Horn, Holger Kirsten, Peter Ahnert, and Markus Scholz. "Comparing performance of modern genotype imputation methods in different ethnicities." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213865.

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A variety of modern software packages are available for genotype imputation relying on advanced concepts such as pre-phasing of the target dataset or utilization of admixed reference panels. In this study, we performed a comprehensive evaluation of the accuracy of modern imputation methods on the basis of the publicly available POPRES samples. Good quality genotypes were masked and re-imputed by different imputation frameworks: namely MaCH, IMPUTE2, MaCH-Minimac, SHAPEIT-IMPUTE2 and MaCH-Admix. Results were compared to evaluate the relative merit of pre-phasing and the usage of admixed references. We showed that the pre-phasing framework SHAPEIT-IMPUTE2 can overestimate the certainty of genotype distributions resulting in the lowest percentage of correctly imputed genotypes in our case. MaCH-Minimac performed better than SHAPEIT-IMPUTE2. Pre-phasing always reduced imputation accuracy. IMPUTE2 and MaCH-Admix, both relying on admixed-reference panels, showed comparable results. MaCH showed superior results if well-matched references were available (Nei’s GST ≤ 0.010). For small to medium datasets, frameworks using genetically closest reference panel are recommended if the genetic distance between target and reference data set is small. Our results are valid for small to medium data sets. As shown on a larger data set of population based German samples, the disadvantage of pre-phasing decreases for larger sample sizes.
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Hansen, Mario Jens. "Genotyp-Identifizierung und Wechselwirkungen an zwei Populus-Chimären." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=97815374X.

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Seidel, Jürgen. "Genotyp-Phänotyp Korrelation bei congenitalem Long QT-Syndrom." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-7555.

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Garcia, Angarita Natalia. "Genotyp/Phänotyp-Analyse bei kongenitalen und hereditären Myopathien." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155263.

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Hansen, Mario Jens. "Genotyp-Identifizierung und Wechselwirkungen an zwei Populus-Chimären." Doctoral thesis, Humboldt-Universität zu Berlin, Landwirtschaftlich-Gärtnerische Fakultät, 2005. http://dx.doi.org/10.18452/15385.

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Zwei Populus-Pfropfchimären (MA und AI), die aus P. x canadensis ‘Marilandica’ (M), P. maximowizcii x P. trichocarpa ‘Androscoggin’ (A) and P. nigra L. ’Italica’ (I) aufgebaut sind, wurden für Untersuchungen zur Laub- und Blütenblattentwicklung genutzt. In MA bildet M die äußere Lage (L1) und ihr Derivat, die Epidermis, während die inneren Lagen (L2, L3 etc.) von A gebildet werden. Bei AI stammt die L1 von A und L2, L3 etc. werden von I gebildet. Die genotypisch andersartige Epidermis bedingt bei Periklinal-Chimären morphologische Effekte wie zum Beispiel einen Fruchtknoten in einigen MA-Blüten. Morphologische Besonderheiten verschiedener Gewebe sowohl von M und A als auch von MA wurden verglichen, um festzustellen, wie sie durch die Gewebetransplantation verändert oder beeinflusst wurden und, um mögliche Genotyp- Interaktionen oder -Wechselwirkungen in einem Gewebe ausfindig zu machen. Für die Genotypidentifizierung in verschiedenen Organen wurde die RAPD-PCR getestet. Einer von 20 getesteten 10mer Zufallsprimern (GGAGTGGACA) ermöglichte bei der Verwendung von DNA aus Blattmaterial die Erzeugung verschiedener Bandenmuster für M und A. Bei der Verwendung von MA-Blattmaterial zeigte sich eine Kombination der Muster von M und A, sodass ein Chimärennachweis für das MA-Blattmaterial erbracht wurde. Für ein übertragbares System wurde die spezifische PCR getestet. Unter Verwendung spezifischer Primer für die 16s-rDNA zeigten die PCR-Produkte einheitliche Banden und nach anschließender Sequenzierung eine weitgehende Übereinstimmung der phylogenetischen Verwandtschaft von I, M und A. Weiterhin wurden die kernkodierten rDNA Bereiche ITS 1 und ITS 2 zwischen 18S und 25S getestet. Für I, M und A konnten jeweils zwei Banden von unterschiedlicher Größe und Sequenz ermittelt werden, die vermutlich auf funktionierende rDNA aber auch auf Pseudogene (beschnitten) in niedriger Kopienzahl hinweisen. Die ITS-Regionen von I, M und A wurden charakterisiert, um einen Einblick in die Struktur und Phylogenie der Salicacaee-Familie zu erhalten. Aus den Sequenzunterschieden konnten für I und A spezifische Primerpaare abgeleitet werden, die für die Identifizierung von I und A in AI und MA verwendet werden können. Mittels A-Marker konnte nachgewiesen werden, dass Fruchtknoten aus MA-Blüten neben M-Gewebe auch den A-Genotyp enthalten.
Two Populus graft chimeras (MA and AI) produced of P. x canadensis ‘Marilandica’ (M), P. maximowizcii x P. trichocarpa ‘Androscoggin’ (A) and P. nigra L. ’Italica’ (I) were used for investigations of leaf and flower development. In MA the exogenous layer (L1) forms the epidermis and is derived from M while inner layers (L2, L3 etc.) descend from A whereas in AI L1 is formed by A while L2, L3 etc. descend from I. The exogenous epidermis of the periclinal chimeras imposes morphological effects such as an extra female sex in some of the MA flowers. The morphological characteristics of different plant tissues of parents and chimera were compared to determine how they were modified or altered by the tissue transplantation and possibly identify co-existing or interacting genotypes in one tissue. RAPD-PCR was tested for its usefulness to amplify polymorphic fingerprints including donor specific DNA fragments. One random 10mer primer (GGAGTGGACA) out of 20 tested revealed the amplification of patterns including donor specific DNA bands using extracts from leaf tissues of the M and A parents that were combined using extract from leaf tissue of the MA chimera. This indicates that the leaves of the MA chimera are formed by tissues of M and A. However, the inherent disadvantage of RAPD-PCR is the reproducibility of PCR product generation. Therefore the discriminative potential of the ITS region located between the rRNA genes was investigated. The application of specific 16S ribosomal DNA (rDNA) primers for amplification and sequencing of PCR products revealed a closely phylogenetic relationship between I, M and A. Consequently the ITS1 and ITS2 of nuclear rDNA between 18S and 25S were used. The amplified fragments were purified, cloned in E. coli and sequenced. Analyses of multiple clones demonstrated extensive paralogy within and between I, M and A ITS operons. For each parent were at least two rDNA operons as well as multiple paralogous sequences within operons identified. The use of PCR and sequence analyses showed that one of the operons encodes a putative expressed (functional) rDNA whereas the second encodes a pseudogen (truncated) in low copy number. We also characterized the ITS regions of I, M and A to gain insights into structure and phylogeny of the Salicacaee family. Based on sequence divergence primers were designed for A and I and used for the identification of A in MA carpels.
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Behrends, Thomas. "Zur Interaktion von Genotyp und Ernährung bei Darmkrebs." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16661.

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Ziel dieser Arbeit war es, sowohl die Auswirkungen einer veränderten Selenversorgung über die Nahrung als auch die Rolle des zentralen Transport- und Speicherproteins für Selen (Selenoprotein P, SepP) auf die intestinale Tumorigenese tierexperimentell zu untersuchen. Eine gestörte SepP-Expression, führte zur Ausbildung größerer Tumore. Durch eine Steigerung der Selenversorgung über die Nahrung eine signifikante Reduktion von Tumoranzahl und Gesamttumorfläche erzielt werden. Hierzu wurde den Tieren ab Tag 21 das Vierfache der empfohlenen Tagesdosis (RDA) für Selen verabreicht. Die Ergebnisse zeigten zudem, dass die Auswirkungen einer verminderten SepP-Expression durch eine nutritive Se-Supplementation kompensiert werden können. Der Verlust eines SepP-Allels war mit einer gesteigerten Infiltration von Mastzellen ins Tumorgewebe und höheren Il6-Spiegeln im Serum assoziiert. Auch waren die Tumore dieser Versuchsgruppen schlechter differenziert. Diese Resultate weisen auf eine modulatorische Wirkung von SepP auf die krebsbedingte Immunantwort hin und unterstreichen eine zentrale Rolle dieses Selenoproteins in Bezug auf anti-kanzerogene Wirkmechanismen von Selen. Die Ergebnisse dieser Arbeit zeigen somit erstmals die Abhängigkeit protektiver Selen-vermittelter Effekte von einer optimalen SepP-Expression und die präventiven Fähigkeiten einer gesteigerten Selenzufuhr zur Kompensation eines nachteiligen Genotyps. Somit können gerade Menschen, die z.B. aufgrund ihrer genetischen Prädisposition ein erhöhtes Darmkrebsrisiko aufweisen von einer gesteigerten präventiven Supplementation profitieren. Dennoch zeigen Vorarbeiten und die Ergebnisse zu den transgenen Versuchstieren, dass es gerade in Bezug auf eine therapeutische Anwendung unabdingbar ist, ein wachstumsförderndes Potential einer solchen Intervention nach erfolgter Tumorinitiation auszuschließen. Hierzu muss in weitergehenden Studien noch eine geeignete Strategie entwickelt und getestet werden.
The aim of this work was to evaluate to which extend the gene expression of the central transport and storage protein for selenium (Selenoprotein P, SepP) is required to mediate health promoting effects and if these effects can be modulated by selenium supplementation. SepP+/--mice were crossed with Apcmin/+-mice to elucidate the potential disadvantage of a decreased SepP-expression. A third mouse strain, expressing human SEPP in liver, was used to study the beneficial effects of additional circulating human SEPP. Two diets with different selenium content were used to obtain better insights into how SepP-expression influences intestinal tumorigenesis. The loss of one SepP-allele resulted in the development of larger tumors. Overall tumor-count and -area could be reduced by increasing nutritional selenium concentrations. Increased tumorigenesis could thus be compensated for raising nutritional Se concentrations. Interestingly, the additional expression of human SEPP did not elicit any cancer-preventive action. An increased number of mast cells was found in tumorous tissue of SepP+/--mice. This was accompanied by a lower differentiation state and higher Il6 concentrations in serum of heterozygous mice. The results indicate that the SepP genotype is modulating the immune response and highlight the central role of SepP in mediating the anti-cancerogenic effects of Se. We are the first to show that protective effects of Se are related to the expression of SepP and that the negative outcome of a reduced expression can be alleviated by raising nutritional Se supply. Individuals with a higher risk for colorectal cancer may thus benefit from supplementation strategies. Nevertheless the data obtained from transgenic mice and the results of previous studies indicate that therapeutic administration of Se should be handled with care. Especially the potential danger of supplemental Se promoting tumor growth in advanced stages should be addressed in further investigations.
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Petersen, Iver. "Genetik von Karzinomen des Respirationstraktes: Korrelation Genotyp - Phänotyp." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 1999. http://dx.doi.org/10.18452/13713.

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Ölvebo, Isabelle. "Leukotoxinproduktion i isolat från Aggregatibacter actinomycetemcomitans : En parodontitpatogen med stor genetisk variation." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58569.

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Gumbinger, Christoph Karl. "Phänotyp-Genotyp-Korrelation bei Patienten mit fokalen kortikalen Dysplasien /." Freiburg i.Br, 2007. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278439.

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Beicht, Sonja. "Genotyp-Phänotyp-Korrelation bei Alport-Patientinnen und Alport-Patienten." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-183613.

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Books on the topic "Genotyp"

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Zordan, Sabrina. Diversität und Klonalität multiresistenter Acinetobacter-Stämme von Patienten deutscher Tierkliniken und Tierarztpraxen. Gießen: VVB Laufersweiler, 2011.

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Zielonka, Stefan, and Simon Krah, eds. Genotype Phenotype Coupling. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-4939-9853-1.

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D'Adamo, Peter. The genotype diet. New York: Broadway Books, 2007.

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Sue, Malcolm, and Goodship Timothy H. J, eds. Genotype to phenotype. 2nd ed. Oxford: BIOS Scientific, 2001.

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K, Campbell R., Eikenbary Raymond D, and International Congress of Entomology (18th : 1988 : Vancouver, B.C.), eds. Aphid-plant genotype interactions. Amsterdam, Netherlands: Elsevier, 1990.

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Brown, T. A. Genomy. Warszawa: Wydaw. Naukowe PWN, 2001.

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Roche, Karen. Genotype Detection In Environmental Samples. Dublin: University College Dublin, 1998.

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Bulanov, Marat. Politicheskai︠a︡ genetika: Integralʹnai︠a︡ individualʹnostʹ kak genotip. Moskva: Algoritm, 2012.

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Kilʹchevskiĭ, A. V. Genotip i sreda v selekt͡s︡ii rasteniĭ. Minsk: "Nauka i tekhnika", 1989.

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Frommlet, Florian, Małgorzata Bogdan, and David Ramsey. Phenotypes and Genotypes. London: Springer London, 2016. http://dx.doi.org/10.1007/978-1-4471-5310-8.

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Book chapters on the topic "Genotyp"

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Toepfer, Georg. "Genotyp/Phänotyp." In Historisches Wörterbuch der Biologie, 59–71. Stuttgart: J.B. Metzler, 2011. http://dx.doi.org/10.1007/978-3-476-00455-0_5.

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Kuhlmann, Inga, Dawn Chin, and Gerald Rimbach. "Apolipoprotein E-Genotyp und Gefäßgesundheit." In essentials, 25–28. Wiesbaden: Springer Fachmedien Wiesbaden, 2014. http://dx.doi.org/10.1007/978-3-658-08359-5_6.

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Egensperger, R., S. Kösel, C. B. Lücking, P. Mehraein, and M. B. Graeber. "Untersuchungen zum Apolipoprotein E-Genotyp an histologisch gesicherten Fällen von Morbus Alzheimer." In Aktuelle Perspektiven der Biologischen Psychiatrie, 541–47. Vienna: Springer Vienna, 1996. http://dx.doi.org/10.1007/978-3-7091-6889-9_130.

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Grimm, T., and C. R. Müller. "Indirekte Genotyp-Diagnostik Neue Möglichkeiten der Heterozygoten- und Pränatal-Diagnose bei monogenen Erbkrankheiten." In Molekularbiologische Methoden in der Diagnostik, 51–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83748-7_5.

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Siegert, G., H. Kostka, S. Gehrisch, and W. Jaross. "Verminderte APC-Response verursacht durch einen häufigen Genotyp der B-Domäne des Faktors V." In 28. Hämophilie-Symposion Hamburg 1997, 343–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-59915-6_54.

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Montesinos López, Osval Antonio, Abelardo Montesinos López, and Jose Crossa. "Bayesian Genomic Linear Regression." In Multivariate Statistical Machine Learning Methods for Genomic Prediction, 171–208. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-89010-0_6.

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AbstractThe Bayesian paradigm for parameter estimation is introduced and linked to the main problem of genomic-enabled prediction to predict the trait of interest of the non-phenotyped individuals from genotypic information, environment variables, or other information (covariates). In this situation, a convenient practice is to include the individuals to be predicted in the posterior distribution to be sampled. We explained how the Bayesian Ridge regression method is derived and exemplified with data from plant breeding genomic selection. Other Bayesian methods (Bayes A, Bayes B, Bayes C, and Bayesian Lasso) were also described and exemplified for genome-based prediction. The chapter presented several examples that were implemented in the Bayesian generalized linear regression (BGLR) library for continuous response variables. The predictor under all these Bayesian methods includes main effects (of environments and genotypes) as well as interaction terms related to genotype × environment interaction.
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Yusop, Mohd Rafii, Yusuff Oladosu, Abdul Rahim Harun, Asfaliza Ramli, Ghazali Hussin, Mohd Razi Ismail, and Norhani Abdullah. "Application of mutation techniques and genotype × environment interaction for grain yield in ion beam induced mutant rice lines tested in multiple locations in Malaysia." In Mutation breeding, genetic diversity and crop adaptation to climate change, 226–34. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0023.

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Abstract Genotype evaluation for stability and high yield in rice is an important factor for sustainable rice production and food security. These evaluations are essential, especially when the breeding objective is to release rice with high yields, adaptability and stability for commercial cultivation. To achieve this objective, this study was carried out to select high-yielding rice genotypes induced by ion beam irradiation. Seeds of the rice variety 'MR219' were subjected to different doses of 320 MeV carbon-ion beam irradiation to determine the optimum dose to produce high mutant frequency and spectrum. The optimum dose was 60 Gy. After several cycles of selection and fixation between 2009 and 2014 (M0-M6), six prospective lines with desirable characters were selected at the M6 generation. The selected mutant lines along with other mutant varieties were then tested at five locations in two planting seasons to select high-yielding and stable genotypes. The experiment was conducted in a randomized complete block design with three replications across the locations and seasons. The pooled analysis of variance revealed highly significant differences (p ≤ 0.01, 0.05) among genotypes, among locations and among genotypes by location by season (G×L×S interaction) for the yield traits except for seasons and genotype by season (G×S interaction). Based on univariate and multivariate stability parameters, rice genotypes were classified into three main categories. The first group comprised genotypes with high yield stability along with high yield per hectare. These genotypes include ML4 and ML6 and are widely adapted to diverse environmental conditions. One line exhibited high yield per hectare but low stability; this genotype (ML9) is suitable for specific environments. The last group had low yield per hectare and high stability and included 'MR220', 'Binadhan4' and 'Binadhan7'. This final group is more suitable for breeding specific traits or perhaps has yield component compensation. Hence, rice mutant lines ML4 and ML6 were recommended for commercial cultivation in Malaysia.
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von Depka Prondzinski, M., A. Berger, I. Scharrer, and B. Weber. "Chronische Hepatitis C, HCV-Virämie und HCV-Genotyp bei HIV-seropositiven und HIV-seronegativen Hämophilen." In 25. Hämophilie-Symposion Hamburg 1994, 218–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-79648-7_29.

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Hahn, Martin, and Rohan Palmer. "Genotype." In Encyclopedia of Clinical Neuropsychology, 1555. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1859.

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Hahn, Martin, and Rohan Palmer. "Genotype." In Encyclopedia of Clinical Neuropsychology, 1141. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1859.

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Conference papers on the topic "Genotyp"

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Dofek, S., P. Gamerdinger, S. Fehr, S. Biskup, M. Müller, H. Löwenheim, and A. Tropitzsch. "Genotyp-Phänotyp-Korrelation bei Genetischer Schwerhörigkeit." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640289.

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Reichert, MC, M. Merkel, C. Schneider, R. Greinert, A. Zipprich, T. Speer, C. Ripoll, and F. Lammert. "Genotyp-stratifiziertes Lipidprofil bei Patienten mit Leberzirrhose." In Viszeralmedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1695277.

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Tropitzsch, A., S. Dofek, F. Schneider, P. Gammerdinger, S. Lodes, M. Müller, H. Löwenheim, B. Vona, and M. Holderried. "Ergebnisprognose bei Cochlea-Implantat Patienten, eine Genotyp-Phänotyp-Korrelation." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686299.

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Matiqi, T. "Genotyp und Phänotyp Extension bei kongenitaler dyserythropoetischer Anämie Typ 1." In HÄMATOLOGIE HEUTE 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1684070.

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Fromme, M., J. Kümpers, A. Arslanow, K. Hamesch, M. Mandorfer, CV Heimes, C. Lindhauer, et al. "Metabolische Veränderungen bei Erwachsenen mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ Genotyp)." In Viszeralmedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1695584.

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Fromme, M., A. Arslanow, K. Hamesch, M. Mandorfer, CV Schneider, C. Lindhauer, V. Woditsch, et al. "Metabolische Veränderungen bei Erwachsenen mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ Genotyp)." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402178.

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Fromme, M., CV Schneider, K. Hamesch, P. Ellis, V. Pereira, M. Pons, J. Genesca, et al. "Leberphänotyp bei Erwachsenen mit compound-heterozygotem Alpha1-Antitrypsin-Mangel (Genotyp Pi*SZ)." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1721992.

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Kaa, A., and M. Wencker. "Diagnose und Heimselbsttherapie eines Patienten mit schwerem A1AT-Mangel mit homozygotem Genotyp MNichinan." In 61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403376.

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Bartl, T., A. Alberts, A. Wolf, G. Hofstetter, L. Müllauer, C. Grimm, and D. Castillo-Tong Cacsire. "PD-L1 als potentielles Therapieziel für eine Subgruppe muzinöser Ovarialkarzinome mit hypermutiertem Genotyp." In Kongressabstracts zur Jahrestagung der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) 2022. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1750229.

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Bayer, Sandra, Theresa Drabsch, Marian Eberl, Hans Hauner, and Christina Holzapfel. "Assoziation von Ruheenergieverbrauch, FTO-Genotyp und Blutparametern mit Gewichtsveränderung über 3 Jahre (#76)." In Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1755709.

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Reports on the topic "Genotyp"

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Weller, Joel, Harris Lewin, Micha Ron, and George Wiggans. Detection and Mapping of Genes Affecting Traits of Economic Importance in Dairy Cattle with the Aid of Molecular Genetic Markers. United States Department of Agriculture, December 1995. http://dx.doi.org/10.32747/1995.7613024.bard.

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Forty-seven poly-TG microsatellites were developed at the U of IL, and 11 genetic markers were developed at ARO, nine of which were poly-AGC microsatellites. Markers were typed on the reference families of CSIRO, Australia; GRANADA, Texas; and IRRF, Illinois, for chromosome assignment and linkage mapping. Nine North American al organizations contributed semen to the Dairy Bull DNA Repository (DBDR), which currently has 65,743 units from 3366 bulls. Semen was obtained for 31 out of 35 grandsires. Semen of 28 and 23 sons of two Israeli bulls was also collected. Eighteen grandsires were genotyped for 75 microsatellites. One thousand, three hundred and sixty-two sons with evaluation from 17 families were genotyped for 24 markers. Eleven thousand, six hundred and twenty sons genotypes were determined, of which 8,802 were informative. The genotype data was matched to the bulls' daughter yield deviations (DYD) for seven traits; milk, fat, and protein production; fat and protein percent; somatic cell concentration (SCS); and productive herd life. Seven loci had significant effects at p<0.05, but only two loci, TGLA263 and MGTG7, had significant effects at p<0.01, and the effect of TGLA263 on fat percentage was significant at p<0.0001. There was at least one significant effect for each of the seven traits analyzed.
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Harms, Nathan, Judy Shearer, James Cronin, and John Gaskin. Geographic and genetic variation in susceptibility of Butomus umbellatus to foliar fungal pathogens. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41662.

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Large-scale patterns of plant invasions may reflect regional heterogeneity in biotic and abiotic factors and genetic variation within and between invading populations. Having information on how effects of biotic resistance vary spatially can be especially important when implementing biological control because introduced agents may have different Impacts through interactions with host-plant genotype, local environment, or other novel enemies. We conducted a series of field surveys and laboratory studies to determine whether there was evidence of biotic resistance, as foliar fungal pathogens, in two introduced genotypes (triploid G1, diploid G4) of the Eurasian wetland weed, Butomus umbellatus L. in the USA. We tested whether genotypes differed in disease attack and whether spatial patterns in disease incidence were related to geographic location or climate for either genotype. After accounting for location (latitude, climate), G1 plants had lower disease incidence than G4 plants in the field (38% vs. 70%) but similar pathogen richness. In contrast, bioassays revealed G1 plants consistently received a higher damage score and had larger leaf lesions regardless of pathogen. These results demonstrate that two widespread B. umbellatus genotypes exhibit different susceptibility to pathogens and effectiveness of pathogen biological controls may depend on local conditions.
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Hovav, Ran, Peggy Ozias-Akins, and Scott A. Jackson. The genetics of pod-filling in peanut under water-limiting conditions. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597923.bard.

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Pod-filling, an important yield-determining stage is strongly influenced by water stress. This is particularly true for peanut (Arachishypogaea), wherein pods are developed underground and are directly affected by the water condition. Pod-filling in peanut has a significant genetic component as well, since genotypes are considerably varied in their pod-fill (PF) and seed-fill (SF) potential. The goals of this research were to: Examine the effects of genotype, irrigation, and genotype X irrigation on PF and SF. Detect global changes in mRNA and metabolites levels that accompany PF and SF. Explore the response of the duplicate peanut pod transcriptome to drought stress. Study how entire duplicated PF regulatory processes are networked within a polyploid organism. Discover locus-specific SNP markers and map pod quality traits under different environments. The research included genotypes and segregating populations from Israel and US that are varied in PF, SF and their tolerance to water deficit. Initially, an extensive field trial was conducted to investigate the effects of genotype, irrigation, and genotype X irrigation on PF and SF. Significant irrigation and genotypic effect was observed for the two main PF related traits, "seed ratio" and "dead-end ratio", demonstrating that reduction in irrigation directly influences the developing pods as a result of low water potential. Although the Irrigation × Genotype interaction was not statistically significant, one genotype (line 53) was found to be more sensitive to low irrigation treatments. Two RNAseq studies were simultaneously conducted in IL and the USA to characterize expression changes that accompany shell ("source") and seed ("sink") biogenesis in peanut. Both studies showed that SF and PF processes are very dynamic and undergo very rapid change in the accumulation of RNA, nutrients, and oil. Some genotypes differ in transcript accumulation rates, which can explain their difference in SF and PF potential; like cvHanoch that was found to be more enriched than line 53 in processes involving the generation of metabolites and energy at the beginning of seed development. Interestingly, an opposite situation was found in pericarp development, wherein rapid cell wall maturation processes were up-regulated in line 53. Although no significant effect was found for the irrigation level on seed transcriptome in general, and particularly on subgenomic assignment (that was found almost comparable to a 1:1 for A- and B- subgenomes), more specific homoeologous expression changes associated with particular biosynthesis pathways were found. For example, some significant A- and B- biases were observed in particular parts of the oil related gene expression network and several candidate genes with potential influence on oil content and SF were further examined. Substation achievement of the current program was the development and application of new SNP detection and mapping methods for peanut. Two major efforts on this direction were performed. In IL, a GBS approach was developed to map pod quality traits on Hanoch X 53 F2/F3 generations. Although the GBS approach was found to be less effective for our genetic system, it still succeeded to find significant mapping locations for several traits like testa color (linkage A10), number of seeds/pods (A5) and pod wart resistance (B7). In the USA, a SNP array was developed and applied for peanut, which is based on whole genome re-sequencing of 20 genotypes. This chip was used to map pod quality related traits in a Tifrunner x NC3033 RIL population. It was phenotyped for three years, including a new x-ray method to phenotype seed-fill and seed density. The total map size was 1229.7 cM with 1320 markers assigned. Based on this linkage map, 21 QTLs were identified for the traits 16/64 weight, kernel percentage, seed and pod weight, double pod and pod area. Collectively, this research serves as the first fundamental effort in peanut for understanding the PF and SF components, as a whole, and as influenced by the irrigation level. Results of the proposed study will also generate information and materials that will benefit peanut breeding by facilitating selection for reduced linkage drag during introgression of disease resistance traits into elite cultivars. BARD Report - Project4540 Page 2 of 10
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Amzeri, Achmad, B. S. DARYONO, and M. SYAFII. GENOTYPE BY ENVIRONMENT AND STABILITY ANALYSES OF DRYLAND MAIZE HYBRIDS. SABRAO Journal of Breeding and Genetics, September 2020. http://dx.doi.org/10.21107/amzeri.2020.2.

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The phenotypic analysis of new candidate varieties at multiple locations could provide information on the stability of their genotypes. We evaluated the stability of 11 maize hybrid candidates in five districts in East Java Province, Indonesia. Maize hybrids with high yield potential and early maturity traits derived from a diallel cross were planted in a randomized complete block design with two checks (Srikandi Kuning and BISI-2) as a single factor with four replicates. The observed traits were grain yield per hectare and harvest age. The effects of environment, genotype, and genotype × environment interaction on yield were highly significant (P < 0.01). KTM-1, KTM-2, KTM-4, KTM-5, and KTM-6 showed higher average grain yield per hectare than the checks (Srikandi Kuning = 8.49 ton ha−1 and BISI-2 = 7.32 ton ha−1) at five different locations. The average harvest age of 11 candidates was less than 100 days. KTM-4 and KTM-5 had production yields that were higher than the average yield of all genotypes in all environments (Yi > 7.78 tons ha−1) and were considered stable on the basis of three stability parameters, i.e., Finlay–Wilkinson, Eberhart–Russell, and additive main effect multiplicative interaction (AMMI). KTM-2 had the highest yield among all tested genotypes (9.33 ton ha−1) and was considered as stable on the basis of AMMI but not on the basis of Finlay–Wilkinson and Eberhart–Russell. KTM-1 performed well only in Pamekasan, whereas KTM-6 performed well only in Sampang. Thus, these two genotypes could be targeted for these specific locations.
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Amzeri, Achmad. Evaluasi Nilai Heterosis dan Heterobeltiosis Pada Persilangan Dialel Tanaman Jagung Madura (Zea mays L.). Universitas Islam Madura, December 2016. http://dx.doi.org/10.21107/amzeri.2016.1.

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Identifikasi heterosis dan heterobeltiosis pada persilangan dialel diantara galur inbrida Madura sangat dibutuhkan sebagai dasar untuk merakit varietas jagung hibrida yang sesuai untuk dikembangkan di Madura. Penelitian ini bertujuan mengidentifikasi kombinasi persilangan yang menunjukkan nilai heterosis dan heterobeltiosis terbaik untuk karakter kegenjahan, penunjang produksi dan produksi per hektar. Penelitian ini dilaksanakan di Kebun Percobaan Fakultas Pertanian Universitas Trunojoyo Madura. Bahan tanaman yang digunakan adalah 6 genotip galur inbred jagung madura (UTM 2, UTM 7, UTM 14, UTM 14, UTM 15, UTM 18, dan UTM 22), dan 30 hibrida hasil persilangan dialel penuh (full diallel cross) antar 6 genotip galur inbred. Rancangan percobaan yang digunakan adalah rancangan kelompok lengkap teracak (RKLT) faktor tunggal, yaitu genotipe dengan tiga ulangan sehingga terdapat 108 satuan percobaan. Karakter yang diamati adalah umur berbunga, umur panen, diameter tongkol, panjang tongkol, bobot 100 biji, dan produksi per hektar. Persilangan yang menghasilkan nilai heterosis dan heterosbeltiosis terbaik untuk umur genjah adalah UTM14 x UTM18, UTM15 x UTM2 dan UTM18 x UTM2. Hasil persilangan untuk karakter diameter tongkol, panjang tongkol dan berat 100 biji sebagian besar menghasilkan nilai heterosis dan heterobeltiosis bernilai positif. Pada karakter produksi per hektar nilai heterosis dan heterobeltiosis tertinggi pada persilangan UTM2 x UTM14 (214,742%) dan UTM2 x UTM18 (171,585%).
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Shtienberg, Dan, William Fry, Amos Dinoor, Thomas Zitter, and Uzi Kafkafi. Reduction in Pesticide Use in Plant Disease Control by Integration of Chemical and Non-Chemical Factors. United States Department of Agriculture, May 1995. http://dx.doi.org/10.32747/1995.7613027.bard.

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The long term goal of this research project was to improve control efficiency of Alternaria diseases while reducing fungicide use, by integration of chemical and non-chemical factors. Non-chemical factors were genotype resistance, age-related resistance and fertilizers. The Specific objectives were: 1) To quantify changes in resistance among genotypes and over time in terms of disease development and specific phases of the disease cycle; 2) To quantify the effects of fertilizers applied to the foliage alone, or in combination with a fungicide, on disease development; 3) To quantify the relative contribution of genotype resistance, age-related resistance and fungicide type to the reduction of disease development; 4) To develop a strategy for integration of chemical and non-chemical factors which will achieve optimal disease suppression. The influence of physiological age of cotton plants and of the individual leaves, on disease incidence and on the rate of lesion expansion of A. macrospora was examined on leaves sampled from the field. Both parameters increased with the physiological age of individual leaves but were not affected by the age of the whole plant. The hypothesis that enrichment of the foliage with nitrogen and potassium may enhance host resistance to Alternaria and thus reduce disease severity, was examined for potato and tomato (A. solani ) and for cotton (A. macrospora ). Under controlled environment conditions, application of urea or KNO3 resulted in some reduction in disease development; however, foliar application of both nutrients (8-10 sprays in total) did not affect Alternaria severity in the field. Systemic fungicides against Alternaria (e.g. , tebuconazole and difenoconazole) are more effective than the commonly used protectant fungicides (e.g. mancozeb and chlorothalonil). Concepts for the integration of genotype resistance, age-related resistances and fungicide for the suppression of Alternaria diseases were developed and evaluated. It was found that reduction in host resistance, with age and among genotypes, can be compensated for by adjusting the intensity of fungicide applications, i.e. by increasing the frequency of sprays and by spraying systemic fungicides towards the end of the season. In, moderately resistant cultivars protection can be achieved by spraying at longer intervals than susceptible cultivars. The concepts for integration were evaluated in field trials for cotton, potatoes and tomatoes. By following these concepts it was possible to save up to five sprays out of 8-10 in a growing season.
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Gelmann, Edward P. NKX3.1 Genotype and IGF-1 Interact in Prostate Cancer Risk. Fort Belvoir, VA: Defense Technical Information Center, May 2008. http://dx.doi.org/10.21236/ada488982.

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Mitchell, Erika J. The Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma. Fort Belvoir, VA: Defense Technical Information Center, May 2010. http://dx.doi.org/10.21236/ada613874.

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Mitchell, Erika J. The Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma. Fort Belvoir, VA: Defense Technical Information Center, May 2011. http://dx.doi.org/10.21236/ada613875.

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Gelmann, Edward P. NKX3.1 Genotype and IGF-1 Interact in Prostate Cancer Risk. Fort Belvoir, VA: Defense Technical Information Center, May 2010. http://dx.doi.org/10.21236/ada535355.

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