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Dissertations / Theses on the topic 'Gens combinations'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Pati, Amrita. "Modeling and Analysis of Regulatory Elements in Arabidopsis thaliana from Annotated Genomes and Gene Expression Data." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/44132.

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Modeling of cis-elements in the upstream regions of genes is a challenging computational problem. A set of regulatory motifs present in the promoters of a set of genes can be modeled by a biclique. Combinations of cis-elements play a vital role in ascertaining that the correct co-action of transcription factors binding to the gene promoter, results in appropriate gene expression in response to various stimuli. Geometrical and spatial constraints in transcription factor binding also impose restrictions on order and separation of cis-elements. Not all regulatory elements that coexist are biologi

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2

Chen, Ming-Jen. "Combination gene therapy for colorectal cancer." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273724.

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Oncolytic virotherapy with the adenovirus mutant dl 1520 in combination with chemotherapy has shown clinical response. Approaches to cancer gene therapy involving delivery of enzymes to activate the prodrugs CB 1954 and 5-FC are currently being tested in clinical trials. We hypothesised that the combination of an adenoviral vector equivalent to dl1520 with activation ofCB 1954or 5-FC and the combination of CB 1954 activation with 5-FU may further improve the antitumour effects for colorectal cancer therapy. The initial in vitro data showed that the combination of dl 1520 with CB 1954 activatio

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3

Hammar, Cecilia. "Combination of results from gene-finding programs." Thesis, University of Skövde, Department of Computer Science, 1999. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-399.

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<p>Gene-finding programs available over the Internet today are shown to be nothing more than guides to possible coding regions in the DNA. The programs often do incorrect predictions. The idea of combining a number of different gene-finding programs arised a couple of years ago. Murakami and Takagi (1998) published one of the first attempts to combine results from gene-finding programs built on different techniques (e.g. artificial neural networks and hidden Markov models). The simple combinations methods used by Murakami and Takagi (1998) indicated that the prediction accuracy could be improv

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4

Brejova, Bronislava. "Evidence Combination in Hidden Markov Models for Gene Prediction." Thesis, University of Waterloo, 2005. http://hdl.handle.net/10012/1036.

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This thesis introduces new techniques for finding genes in genomic sequences. Genes are regions of a genome encoding proteins of an organism. Identification of genes in a genome is an important step in the annotation process after a new genome is sequenced. The prediction accuracy of gene finding can be greatly improved by using experimental evidence. This evidence includes homologies between the genome and databases of known proteins, or evolutionary conservation of genomic sequence in different species. <br /><br /> We propose a flexible framework to incorporate several different

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5

Repchuk, Yu V. "Does genes combination influence risk of essential arterial hypertension?" Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18057.

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6

Singh, Lovepreet. "Characterization of new sources and superior gene combinations for durable resistance to leaf rust in barley." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24783.

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One hundred fourteen barley lines were screened with diverse pathotypes (pts) of Puccinia hordei in the greenhouse (GH) and field to characterize resistance. The GH tests revealed the presence of all stage resistance (ASR) genes Rph1, Rph2, Rph3, Rph12 and Rph19 either individually or in combination, whereas field tests revealed the presence of adult plant resistance (APR) in 74.5% of the test lines. Molecular markers linked to known genes demonstrated presence of Rph15 (3 lines), Rph20 (5 lines), Rph23 (8 lines), Rph24 (19 lines), and the combinations Rph20+Rph23 or Rph20+Rph24 or Rph23+Rph24

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7

Whitsett, Timothy Glynn. "Breast cancer chemoprevention with the natural polyphenols resveratrol and genistein, alone and in combination." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/whitsett..pdf.

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8

Hosseinkhani, Hossein. "Design of Non-Viral Polymer Vectors and the Ultrasound Combination to Enhance Gene Transfection." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149455.

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9

Freni, Sterrantino Anna <1978&gt. "Combination of gene expression studies. An overview, critical aspects and a proposal of application." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2985/1/FreniSterrantino_Anna_tesi.pdf.

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10

Freni, Sterrantino Anna <1978&gt. "Combination of gene expression studies. An overview, critical aspects and a proposal of application." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2985/.

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11

Lambert, Carol-Ann. "A novel marker technique : using miniature inverted-repeat transposable elements (MITEs) in combination with resistant gene analogues (RGAs)." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52117.

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Thesis (PhD)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Given the organisation of the maize genome as well as demands placed on the saturation of molecular linkage maps it would be desirable to identify informative molecular markers that is located or linked to genic rich areas. Sequences of gene products from different gene classes were investigated. Proteins containing a nucleotide binding site (NBS) and leucine-rich repeat (LRR) region comprise the largest class of disease resistance proteins. Resistant gene analogue (RGA) primers belonging to this specific class were derive

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12

Ajaz, Mazhar. "Gene-directed enzyme prodrug therapy with CPG2-ZD2767P : novel vaccina vectors and combination with radiotherapy." Thesis, Institute of Cancer Research (University Of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536052.

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13

Becker, Michelle Caitlin. "The Combination of Carboxylesterase-Expressing Oncolytic Vaccinia Virus and Irinotecan." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23653.

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This project combines oncolytic Vaccinia virus (VV) with irinotecan (CPT-11) for the treatment of cancer. VV can infect, replicate in and destroy cancer cells, yet leave healthy cells relatively unaffected. CPT-11 is a chemotherapeutic of which ~5% is converted to the more active chemotherapeutic SN-38 by endogenous carboxylesterase (CE) enzymes. SN-38 is a topoisomerase I inhibitor that induces DNA double strand breaks, leading to growth arrest and apoptosis. Consequently, VV has been engineered to express a more effective isoform of the CE enzyme. The virus’ tumour tropism should restrict en

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14

Singh, Preetinder Pal Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "A combination of molecular and traditional chemotherapy: prospects of synergies against cancer." Awarded by:University of New South Wales. Clinical School - Prince of Wales Hospital, 2009. http://handle.unsw.edu.au/1959.4/44564.

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In this study, we have explored the combination of a novel Purine Nucleoside Phosphorylase mediated Gene-Directed Enzyme Prodrug Therapy (PNP-GDEPT) with chemotherapeutics, Taxotere and/or Carboplatin to target prostate and ovarian cancer (PC & OC). PNP converts the prodrug (Fludarabine-phosphate) to a toxic purine, 2-fluoroadenine (2FA) that inhibits RNA/DNA synthesis. Taxotere is active against late stage PC whilst carboplatin is first line therapy for OC. Neither modality is adequately effective. We expect that a combination will target heterogeneity via cytotoxicity to diverse cancer cell

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15

Mohamed, Nada Abdelrahman Nurein. "The effect of a combination therapy of Fluconazole and Amphotericin B on the growth and CDR1 gene expression of Candida glabrata." University of the Western Cape, 2020. http://hdl.handle.net/11394/7265.

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Magister Scientiae Dentium - MSc(Dent)<br>Candida glabrata (C. glabrata/ Cg) is a pathogenic organism that is increasingly developing frank innate and acquired resistance to the most commonly used antifungal agents, namely, azole group of antifungals. Furthermore, C. glabrata-associated oropharyngeal infections affecting immunocompromised patients, are more difficult to treat and the development of resistance worsen the prognosis. Molecular studies related the emergence of resistance in C. glabrata to the upregulation of ATP-binding cassette (ABC) transporter genes, which work by reducing dru

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16

Bauman-Fortin, Jeremy. "Associations Between Variants in the NF- κB1 Gene, Alone or in Combination with Saturated Fats, and Anthropometric Traits in Young Adults". Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35782.

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Animal studies have shown that chronic high consumption of saturated fat (SF) leads to hypothalamic inflammation and ultimately, alters appetite control. This has been shown to be partly due to an increase in the activity of the transcription factor Nuclear Factor-κB (NF-κB), a major regulator of the inflammatory response. The goal of the study was to first confirm the association between SF measurements and anthropometric traits, then to determine the association between single nucleotide polymorphisms (SNPs) in the NF-κB1 gene and body mass index (BMI) and waist circumference (WC), and final

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17

Notaro, Anna. "Understanding the innovative viral glycosylation machinery using a combination of chemical and structural methodologies." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0125.

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The sujet de cette these portait sur la caractérisation de la machinerie originale utilisée par les Mimiviridae pour glycosyler les fibrilles entourant leurs capsides en travaillant sur les prototypes des 3 lignées connues, Mimivirus (A), Megavirus chilensis (B) et Moumouvirus australensis (C). Les fibrilles de Mimivirus sont décorées par 2 polysaccharides différents :l’un est caractérisé par la répétition d’un disaccaride linéaire fait de 3)-α-L-Rha-(1→3)-β-D-GlcNAc-(1→, avec un pyruvate branché en position 4,6 du GlcNAc ; l’autre présente une unité répétée branchée de séquence 2)-α-L-Rha-(1→

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18

Komar, Monica. "Potentiating the Oncolytic Efficacy of Poxviruses." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23114.

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Several wild-type poxviruses have emerged as potential oncolytic viruses (OVs), including orf virus (OrfV), and vaccinia virus (VV). Oncolytic VVs have been modified to include attenuating mutations that enhance their tumour selective nature, but these mutations also reduce overall viral fitness in cancer cells. Previous studies have shown that a VV (Western Reserve) with its E3L gene replaced with the E3L homologue from, OrfV (designated VV-E3LOrfV), maintained its ability to infect cells in vitro, but was attenuated compared to its parental VV in vivo. Our goal was to determine the safety an

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19

Kennedy, Brian Alexander. "Developing the Cis-Regulatory Association Model (CRAM) to Identify Combinations of Transcription Factors in ChIP-Seq Data." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291138540.

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20

Sabatino, Maria Antonietta. "Combination treatments in in vitro and in vivo models between molecules reverting epigenetic gene silencing and DNA-interacting anticancer drugs." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502390.

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Epigenetic transcriptional gene silencing plays a fundamental role in cancer development and has been considered as a target for cancer therapy in the last few years, mainly due to its reversibility by small molecules. Among the several methylated genes investigated, glutathione-S-transferase CGST) PI, a protein belonging to cellular detoxification systems, has been shown to be extensively promoter-methylated in prostate cancer. My study therefore describes a new therapeutic approach against prostate cancer, based on the combination of demethylating agents and brostallicin, a DNA minor groove

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21

Tsuruta, Yuko. "Combination effect of adenovirus-mediated pro-apoptotic Bax gene transfer with cisplatin or paclitaxel treatment in ovarian cancer cell lines." Kyoto University, 2001. http://hdl.handle.net/2433/150565.

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22

Ibach, Tabea [Verfasser]. "Adoptive T-cell Therapy via Chimeric Antigen Receptors (CARs) against Leukemia in Combination with a human Suicide Gene / Tabea Ibach." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1209354136/34.

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23

Dlamini, Sigcinile. "Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27295.

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Young women in areas of high HIV risk are more vulnerable to new HIV infections compared to men. With the development of programmes using anti-retrovirals (ARVs) to prevent HIV infection, the concurrent use of hormonal contraception and ARVs is likely to increase in young women. Products delivering ARVs and hormonal contraceptives intravaginally, are in development, and aim to simultaneously prevent unintended pregnancies and prevent HIV infection. However, little is known about the combinatorial effects of ARVs and hormonal contraceptives in the female genital tract. The mucosal surface in th

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24

Hisatsune, Hiroshi. "High level of endothelial cell-specific gene expression by a combination of the 5' flanking region and the 5' half of the first intron of the VE-cadherin gene." Kyoto University, 2005. http://hdl.handle.net/2433/144381.

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25

Saurya, Shreesh. "Characterization of HIV-1 genes from AIDS patients on combination therapy with discordance between viral load and CD4+ T-cell counts." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620726.

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26

Brusca, James. "Inheritance of tomato late blight resistance from 'Richter's Wild Tomato' and evaluation of late blight resistance gene combinations in adapted fresh market tomato backgrounds." NCSU, 2003. http://www.lib.ncsu.edu/theses/available/etd-06042003-073908/.

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Late blight, caused by the oomycete Phytophthora infestans (Mont.) de Bary, is a destructive disease of tomato worldwide. Originating in the highlands of central Mexico, through migration, mutation, and sexual recombination, this pathogen has proven mobile and highly variable. Three monogenic R genes (Ph-1, Ph-2, and Ph-3) for resistance to late blight have been identified in tomato. However, P. infestans isolates which overcome each of these individual R genes have been documented. The objectives of this research were to characterize the inheritance of late blight resistance in the home garde

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27

Tutter, Mariella [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Challenges and chances of the combination of hyperthermia with mesenchymal stem cell-mediated sodium iodide symporter gene therapy / Mariella Tutter ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1211957543/34.

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28

Wagener, Rabea [Verfasser]. "Identification and characterization of pathogenetically relevant genes in mature aggressive B-cell lymphomas of childhood by a combination of genomic and functional analyses / Rabea Wagener." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1169652824/34.

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29

Fávero, Alessandra Pereira. "Cruzabilidade entre espécies silvestres de Arachis visando à introgressão de genes de resistência a doenças no amendoim cultivado." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-21092004-160937/.

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O amendoim (Arachis hypogaea) é a quarta oleaginosa mais consumida no mundo. O Brasil produziu, em 2002, aproximadamente 190 mil toneladas, sendo que 80% da área plantada situa-se no Estado de São Paulo. O principal problema da cultura neste Estado e no mundo são as doenças fúngicas de parte aérea. Diversas espécies do gênero Arachis são consideradas resistentes a várias pragas e doenças. Os objetivos dessa pesquisa foram: 1) identificar espécies silvestres pertencentes à Secção Arachis resistentes à mancha castanha (Cercospora arachidicola), mancha preta (Cercosporidium personatum) e f

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30

Palmer, Daniel Harrison. "A study of the novel VDEPT cancer gene therapy combination nitroreductase / CB1954 : mechanisms of cell death, modulation of cellular signalling pathways and early phase clinical trials." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403904.

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A major limitation to the success of cancer gene therapy is the low efficiency of gene delivery achieved by currently available vectors. Virus-directed enzyme prodrug therapy aims to overcome this limitation by delivery of an enzyme to the tumour site, which catalyses the conversion of an inert prodrug to a potent cytotoxic. Activation of the prodrug at the tumour site maximises local cell kill whilst minimising systemic toxicity. Importantly, the activated species should pass to neighbouring nontransduced cells to mediate 'bystander' killing. In this way, significant anti-tumour effects may b

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31

Jahic, Sani. "Functional investigation of the potential therapeutic target gene DLG2 in an11q-deleted neuroblastoma cell line and effects of 1,25 vitamin D3 and retinoic acid combination treatments." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12006.

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Neuroblastoma as a pediatric tumor develops in the sympathetic nervous system. DLG2 is a gene that encodes a member of the membrane-associated guanylate kinase (MAGUK) family and it resides in the chromosome region 11q. SK-N-AS is a neuroblastoma cell line with 11q deletion and consequently only one copy of the potential tumor suppressor gene DLG2. This study investigated synergistic effect by a combination treatment with 1,25(OH)2D3 and the vitamin A metabolite, retinoic acid. Separately, SK-N-AS cells was transfected with expression vector pcDNA3.1+‐DYK that contained the DLG2-gene, followe

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32

Liu, Renyan. "Synergistic growth inhibition and enhancement of cell death by combination of Melanoma Differentiation Associated gene-7 (MDA-7/IL-24) and cisplatin in ovarian cancer cell lines." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/7.

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Ovarian cancer is the most lethal gynecological malignancy among women. The current first-line treatments for ovarian cancer are cisplatin, carboplatin and paclitaxel. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Therefore, the resistance to cisplatin therapy has been a critical hurdle in the management of recurrent ovarian cancer. The mechanisms responsible for cisplatin resistance are not completely understood. In the search for new therapies to overcome/bypass cisplatin resist

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33

Abrahams, Beynon. "The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/3846.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. Inhibition of cell growth by TKIs used individually occurred in a dose- and time-dependent manner. When EGFR Inhibitor I, EGFR Inhibitor II/BIBX1382 and the multi-specific EGFR/ErbB-2/ErB-4 Inhibitor were used in combination with each other at equimolar log dose concentrations, the combined effects on cell growth was sign

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34

Datsenko, Yakov [Verfasser]. "Interferon-stimulated gene expression in chronic hepatitis C virus genotype 1 infected patients treated with the NS3/4A protease inhibitor faldaprevir in combination with pegylated interferon alpha-2a/ribavirin / Yakov Datsenko." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/1049561562/34.

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35

Matheux, Alice. "Implication de PXR, Pregnane X Receptor, dans la résistance aux inhibiteurs de kinases en cancérologie : application au cancer de la prostate et mélanome." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT049.

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La résistance clinique aux anticancéreux reste l’une des causes majeures de l’échec des traitements. Cette résistance est multifactorielle et implique un ensemble de mécanismes dont certains ne sont pas encore totalement élucidés. Parmi eux se trouvent des mécanismes impliquant les enzymes du métabolisme et du transport des médicaments dont les gènes sont majoritairement régulés par les récepteurs nucléaires, et notamment PXR (Pregnane X Receptor) ou NR1I2. Son expression et activité via l’expression de ses gènes cibles a souvent été décrite comme étant associée à la chimiorésistance dans des

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36

Mählmann, Kathrin [Verfasser]. "Minimalistic immunologically defined gene expression T helper cell 1 (MIDGE-Th1®) vectors coding for Interleukin 12 and -18 in combination with the transfection agent SAINT-18 have systemic antitumoral effects on equine melanomas / Kathrin Mählmann." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1030346402/34.

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Oliveira, Diogo Fagundes de. "Dilema da diversidade-acur?cia: um estudo emp?rico no contexto de multiclassificadores." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17992.

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Made available in DSpace on 2014-12-17T15:47:49Z (GMT). No. of bitstreams: 1 DiogoFO.pdf: 866073 bytes, checksum: bf59c2597aef9b7382b7e14bd4914265 (MD5) Previous issue date: 2008-09-01<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Multi-classifier systems, also known as ensembles, have been widely used to solve several problems, because they, often, present better performance than the individual classifiers that form these systems. But, in order to do so, it s necessary that the base classifiers to be as accurate as diverse among themselves this is also

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Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula

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Wu, Pei-Tzu, and 吳珮慈. "Cancer Classifier – Feature Selection and Gene Feature Combinations." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/77421859242670457770.

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碩士<br>國立交通大學<br>資訊科學與工程研究所<br>98<br>Breast cancer is the main cause of death for women. Many researchers dedicate to the investigation of cancer classifications, attempting to find malignant tumors and directing therapies in early stages. Therefore, we used feature selection methods and ensemble classifier models to identify and predict on breast cancer classifications. The diagnostic data of breast cancer provide informative and significant knowledge for cancerous classifications. Thus, we apply feature selection technique to retrieve and rank the importance of attributes. Use the attribu

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Chou, Ching-Wen, and 周靜雯. "Combination of Chemotherapy and Gene Therapy in Bladder Cancer." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/79830900382851600191.

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碩士<br>國立成功大學<br>生物化學研究所<br>89<br>The patients with the residual tumor mass or metastatic tumor cells after the surgery is usually responsible for the therapeutic failure, so several experimental evidence strongly suggest to add immunotherapy to the more conventional combination of surgery, radiotherapy and chemotherapy for cancer. In our study, mouse bladder tumor MBT-2 cells and C3H/HeNCrj mice was used as a model. Overexpression of neu was observed in MBT-2 cells. The protein product of neu gene had been proposed to be an attractive target for immunotherapy of mammary tumors. We c

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Davey, Ryan James. "Examining the expression of nucleotide excision repair genes in melanoma tumours." Thesis, 2017. http://hdl.handle.net/1959.13/1337722.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Melanoma is an aggressive form of cancer characterised by poor prognosis and resistance to treatment. Despite recent advances in melanoma treatment, patient outcomes continue to be underwhelming. After these new therapies showed initial promise; resistance and poor duration of response have limited their effectiveness as monotherapies. We are currently at the forefront of a wave of research into the underlying mechanisms of melanoma characteristics. It is now understood that for effective treatments to be developed, we must have a greater unde

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Jing-Yue, Hong. "Differential Combinations of Transcriptional Regulatory Sites in Functionally Related Genes in Yeast Genomes." 2002. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0009-0112200611333943.

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Hong, Jing-Yue, and 洪晶月. "Differential Combinations of Transcriptional Regulatory Sites in Functionally Related Genes in Yeast Genomes." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/95684458756628002591.

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碩士<br>元智大學<br>資訊工程學系<br>90<br>The aim in this study is to investigate the differential combinations of the known regulatory sites and over-represented repetitive elements are distributed in the promoter regions of groups of functionally related genes. This study initially identifies the combinations of known regulatory sites extracted from TRANSFAC and over-represented repetitive oligo-mers stored in RSDB in the promoter regions of a particular set of genes selected. The data mining approach, mining association rules, is then applied to mine the associations from the combinations of over-repre

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Ren, Gang. "Targeted Molecular Imaging: A Guide to Combination Therapy." 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=225.

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Hsu, Yu-Ching, and 徐于晴. "Gene Set-based Approaches for Analyzing Copy Number Alterations and Drug Combinations in Cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/58043718807620325096.

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碩士<br>國立臺灣大學<br>生醫電子與資訊學研究所<br>104<br>With the advances in high-throughput microarray and next-generation sequencing technologies, various statistical methods and mathematical models have been developed to comprehensively explore complex cancer genomes. Recently, a knowledge-based gene set analysis was proposed and successfully carried out remarkable findings from different layers of molecular data, such as gene expression and genomic alterations. Due to its power in detecting functional changes resulted from both significantly and modestly changed genes, gene set analysis pro

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菱田, 光洋, and Mitsuhiro Hishida. "Estrogen receptor 1 gene as a tumor suppressor gene in hepatocellular carcinoma detected by triple-combination array analysis." Thesis, 2014. http://hdl.handle.net/2237/20367.

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Caetano, Marta Daniela Passadouro. "MicroRNA modulation in combination with chemotherapeutic drugs as a novel therapeutic strategy for pancreatic cancer." Doctoral thesis, 2014. http://hdl.handle.net/10316/26516.

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Tese de doutoramento em Bioquímica, na especialidade de Tecnologia Bioquímica, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciência e Tecnologia da Universidade de Coimbra<br>O adenocarcinoma ductal do pâncreas (ACP) é uma neoplasia altamente agressiva, com um carácter acentuadamente invasivo e um perfil de expressão de microRNAs anormal, que tem sido fortemente associado à malignidade do ACP. A gemcitabina é o fármaco mais utilizado na terapia deste tipo de cancro, embora sem grande impacto na sobrevivência dos pacientes. A falta de tratamentos eficazes para o ACP levou-no

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Hutterer, Christine [Verfasser]. "Identification of novel mouse Delta1 target genes : combination of transcriptomics and proteomics / Christine Hutterer." 2005. http://d-nb.info/977701247/34.

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LAI, XIN-ZHI, and 賴信志. "The drug combination effect, biotyping, plasmid transformation and toxin gene probing of aeromonas hydrophila." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/16376548732947344324.

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Olayan, Rawan S. "Finding Combination of Features from Promoter Regions for Ovarian Cancer-related Gene Group Classification." Thesis, 2012. http://hdl.handle.net/10754/264673.

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In classification problems, it is always important to use the suitable combination of features that will be employed by classifiers. Generating the right combination of features usually results in good classifiers. In the situation when the problem is not well understood, data items are usually described by many features in the hope that some of these may be the relevant or most relevant ones. In this study, we focus on one such problem related to genes implicated in ovarian cancer (OC). We try to recognize two important OC-related gene groups: oncogenes, which support the development and pro

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