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Journal articles on the topic 'Gens combinations'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Korolev, Konstantin. "Morphophysiological test of Linum usitatissimum L. under conditions of different levels of chloride salinity." АгроЭкоИнфо 5, no. 65 (2024): 19. http://dx.doi.org/10.51419/202145519.

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The selection of resistant varieties under conditions of abiotic stress is an urgent direction in the adaptive selection of flax. The presented work reflects the assessment of the phenotypic variability of 12 hybrid combinations of flax-longshanks according to the morphophysiological parameters of seedlings under the action of chloride salinization of two levels (E1, E2). The genotypes of flax of the fourth (F4) – fifth (F5) generations were used as objects of research. Significant differences (p>0.05, p>0.01, p>0.001) between hybrid populations and media were revealed for most of the

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SIMBOURA, N., A. ZENETOS, M. A. PANCUCCI-PAPADOPOULOU, S. REIZOPOULOU, and N. STREFTARIS. "Indicators for the Sea-floor Integrity of the Hellenic Seas under the European Marine Strategy Framework Directive: establishing the thresholds and standards for Good Environmental Status." Mediterranean Marine Science 13, no. 1 (2012): 140. http://dx.doi.org/10.12681/mms.31.

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A data set of 625 samples of benthic macroinvertebrates collected from the Hellenic Seas (Ionian and Aegean) was used to establish thresholds and reference standards for two of the indicators addressing the descriptors of Sea-floor Integrity under the Marine Strategy Framework Directive (MSFD): species diversity and richness and the ratio of sensitive species to tolerant species. The dataset was categorised according to the baseline ecological status assessment of the respective water bodies under the Water Framework Directive (WFD). Species diversity and richness were characterised using the

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Ivanov, S. V., S. A. Ramazanova, S. Z. Guchetl, and M. V. Trunova. "Usage of molecular genetic markers for identification of gens of photoperiodic sensitivity in soybean breeding germplasm." Oil Crops 2, no. 198 (2024): 3–9. http://dx.doi.org/10.25230/2412-608x-2024-2-198-3-9.

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Soybean is one of the important oil and forage crops. It contains large amounts of oil, protein, vitamins, and other valuable nutrients. Annually, sowing area under soybean in Russia enlarges towards central and Siberian regions. However, soybean is very sensitive to photoperiod that is a key factor in regulation of soybean growth and development. The identification of gens controlling a photoperiodic sensitivity in soybeans is important for breeding of new adaptive cultivars. DNA-markers are an effective instrument for the selection of valuable genotypes from breeding germplasm. In this work,

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Li, Jin, Yang Huo, Xue Wu, et al. "Essentiality and Transcriptome-Enriched Pathway Scores Predict Drug-Combination Synergy." Biology 9, no. 9 (2020): 278. http://dx.doi.org/10.3390/biology9090278.

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In the prediction of the synergy of drug combinations, systems pharmacology models expand the scope of experiment screening and overcome the limitations of current computational models posed by their lack of mechanical interpretation and integration of gene essentiality. We therefore investigated the synergy of drug combinations for cancer therapies utilizing records in NCI ALMANAC, and we employed logistic regression to test the statistical significance of gene and pathway features in that interaction. We trained our predictive models using 43 NCI-60 cell lines, 165 KEGG pathways, and 114 dru

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Ding, Zhihu, Laiyuan Zhai, Kai Chen, Fan Zhang, Xianjin Qiu, and Jianlong Xu. "Improvement of Rice Salt Tolerance by Pyramiding Two Genes in Xian and Geng Backgrounds Through CRISPR-Cas9 System." Agronomy 15, no. 5 (2025): 1014. https://doi.org/10.3390/agronomy15051014.

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Salinity is one of the main environmental factors influencing rice production. Many genes affecting salt tolerance (ST) have been cloned in rice so far. In the present study, four genes negatively regulating ST, including HST1, LRRK1, STRK2, and PC1, were edited by CRISPR-Cas9 technology in six rice varieties (three in indica (xian) and three in japonica (geng) backgrounds), and three two-gene editing combinations, including hst1-lrrk1, hst1-strk2, and hst1-pc1, were created. All combinations of hst1-pc1, hst1-lrrk1, and hst1-strk2 significantly improved the ST of all the tested materials in b

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Hegewald, Eberhard. "New combinations in the genus Desmodesmus (Chlorophyceae, Scenedesmaceae)." Algological Studies/Archiv für Hydrobiologie, Supplement Volumes 96 (January 1, 2000): 1–18. http://dx.doi.org/10.1127/algol_stud/96/2000/1.

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Khoral, Priya, Robert J. Guo, Jahangir Abdi, and Hong Chang. "Prima-1Met Combined with Bortezomib Has Synergistic Anti-Myeloma Activity By Modulation of Apoptosis and Cell Cycle Regulating Genes." Blood 126, no. 23 (2015): 4213. http://dx.doi.org/10.1182/blood.v126.23.4213.4213.

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Abstract INTRODUCTION Multiple Myeloma (MM) is a plasma-cell malignancy characterized by dismal prognosis and a high level of relapse, thus novel therapeutic approaches are needed. PRIMA-1Met is a novel small molecule showing anti-tumour activity and currently in clinical phase I-II trials. We recently demonstrated that PRIMA-1Met has potent anti-MM activity in vitro and in vivo. Bortezomib (BTZ) is a proteasome inhibitor that has been successfully used for treating some cases of relapsed MM. The aim of the current study is to determine whether PRIMA-1Met could be used in combination with BTZ

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Adhikari, Tika B., Ram Chandra Basnyat, and T. W. Mew. "Virulence of Xanthomonas oryzae pv. oryzae on Rice Lines Containing Single Resistance Genes and Gene Combinations." Plant Disease 83, no. 1 (1999): 46–50. http://dx.doi.org/10.1094/pdis.1999.83.1.46.

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Fifty isolates of Xanthomonas oryzae pv. oryzae were collected from different rice-producing districts of Nepal and evaluated for their virulence on these 11 rice lines having from one to four resistance genes: IRBB4 (Xa4), IRBB5 (xa5), IRBB7 (Xa7), IRBB8 (xa8), IRBB10 (Xa10), IRBB14 (Xa14), and IRBB21 (Xa21), two-gene combination AY4+5 (Xa4 and xa5), three-gene combinations NH21-37-1-1 (Xa4, xa5, and xa13) and NH24-10-1-3 (Xa4, xa5, and Xa21), and four-gene combination NH56-1-44-4 (Xa4, xa5, xa13, and Xa21). The ability of an isolate to cause lesions with different lengths across the lines wa

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Gómez-Gallego, F., C. Santiago, M. González-Freire, et al. "Endurance Performance: Genes or Gene Combinations?" International Journal of Sports Medicine 30, no. 01 (2008): 66–72. http://dx.doi.org/10.1055/s-2008-1038677.

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Gao, Peng, Mingyou Li, Xiaoqiu Wang, et al. "Identification of Elite R-Gene Combinations against Blast Disease in Geng Rice Varieties." International Journal of Molecular Sciences 24, no. 4 (2023): 3984. http://dx.doi.org/10.3390/ijms24043984.

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Rice blast, caused by the Magnaporthe oryzae fungus, is one of the most devastating rice diseases worldwide. Developing resistant varieties by pyramiding different blast resistance (R) genes is an effective approach to control the disease. However, due to complex interactions among R genes and crop genetic backgrounds, different R-gene combinations may have varying effects on resistance. Here, we report the identification of two core R-gene combinations that will benefit the improvement of Geng (Japonica) rice blast resistance. We first evaluated 68 Geng rice cultivars at seedling stage by cha

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Kochetova, Olga V., Tatyana V. Victorova, and Lilya K. Karimova. "The roles of genes of ksenobiotics biotransformation in the development of predisposition to the toxic heoatitis in workers workers exposed to hepthyle and ethylebenzene-styrene." Ecological genetics 3, no. 1 (2005): 3–10. http://dx.doi.org/10.17816/ecogen313-10.

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Introduction: The aim of this study was to estimate the predisposition of influencing possible factors causing chemical induced abnormal liver function on the basis of studying genes encoding xenobiotic metabolizing enzymes. Methods: Genotyping of CYP1A1, CYP2D6, CYP2E1, EPHX1, NAT2 was performed using polymerase chain reaction and restriction fragment length polymorphism on peripheral leucocyte DNA from 73 incident cases of toxic hepatitis, 163 «groups of risk» on development of a toxic hepatitis, 94 healthy workers and 335 controls.Results and conclusions: No significant association was foun

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Yasuda, Nobuko, Takayuki Mitsunaga, Keiko Hayashi, Shinzo Koizumi, and Yoshikatsu Fujita. "Effects of Pyramiding Quantitative Resistance Genes pi21, Pi34, and Pi35 on Rice Leaf Blast Disease." Plant Disease 99, no. 7 (2015): 904–9. http://dx.doi.org/10.1094/pdis-02-14-0214-re.

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Development of resistant cultivars has been an effective method for controlling rice blast disease caused by Magnaporthe oryzae. Quantitative blast resistance genes may offer durable resistance because the selection pressure on M. oryzae to overcome resistance is low as a result of the genes’ moderate susceptibility. Because the effects of individual resistance genes are relatively small, pyramiding these genes in rice cultivars is a promising strategy. Here, we used near-isogenic and backcross lines of rice cultivar Koshihikari with single- or two-gene combinations of blast resistance genes (

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Troitskaya, N. I., K. G. Shapovalov, and V. A. Mudrov. "Analysis of the association of polymorphisms of genes markers functions of endothelium and vascular-plate hemostasis with development of diabetic foot syndrome." Acta Biomedica Scientifica 6, no. 4 (2021): 18–26. http://dx.doi.org/10.29413/abs.2021-6.4.2.

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The aim. To study the prevalence of various combinations of polymorphic variants of genes markers of endothelial function and vascular-platelet hemostasis in the development of diabetic foot syndrome.Materials and methods. In 198 patients with uncomplicated diabetes mellitus and 199 patients with diabetic foot syndrome, the frequency of polymorphic variants of the NOS 786C>T, END1 Lys198Asn, ITGB3 1565T>C (Leu33Pro), F5 1691G>A, F2 20210G>A, MMP9 8202A>G, MTHFR 1298A>C, VEGFA-634C>G genes was studied. Using binary logistic regression analysis, the relationship of various c

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Isakova, Zh T., E. T. Talaibekova, D. A. Asambaeva, et al. "Risk of type 2 diabetes mellitus in the Kyrgyz population in the presence of ADIPOQ (G276T), KCNJ11 (Glu23Lys), TCF7L2 (IVS3C>T) gene polymorphisms." Terapevticheskii arkhiv 89, no. 10 (2017): 40–47. http://dx.doi.org/10.17116/terarkh2017891040-47.

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Aim. To analyze the association of genotype combinations of the polymorphic markers G276T in the ADIPOQ gene, Glu23Lys in the KCNJ11 gene, and IVS3C>T in the TCF7L2 gene with the development of type 2 diabetes mellitus (T2DM) in the Kyrgyz population. Subjects and methods. The investigation enrolled 23 Kyrgyz people, of whom there were 114 patients with T2DM and 109 without T2DM (a control group). T2DM was diagnosed in accordance with the WHO criteria (1999). The genotypes of ADIPOQ (G276T), KCNJ11 (Glu23Lys), and TCF7L2 (IVS3C>T) gene polymorphisms were identified using the restriction

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Skuja, Vita, Katrīna Pekarska, Aleksejs Derovs, et al. "HIGHER CTX-M, TEM, AND SHV EXTENDED-SPECTRUM BETA-LACTAMASE PLASMID GENE COMBINATION FREQUENCY IN ESBL PRODUCING KLEBSIELLA PNEUMONIAE COMPARED WITH ESBL PRODUCING ESCHERICHIA COLI." CBU International Conference Proceedings 4 (September 17, 2016): 732–39. http://dx.doi.org/10.12955/cbup.v4.841.

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Introduction:Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae confer antibiotic resistance to broad-spectrum penicillins, cephalosporins, using ESBL genes CTX-M, TEM, SHV, which are encoded in bacterial plasmid genome. Methods: We compared plasmid CTX-M, TEM, and SHV ESBL gene combinations in ESBL producing Escherichia coliand Klebsiella pneumoniae. Altogether, 136 ESBL producing Enterobacteriaceae isolation cases were analyzed. Results:The ESBL producing Enterobacteriaceae, mostly K. pneumoniae (n = 66; 48.53%), E. coli (n = 36; 26.47%), were isolated from 52 (38.2%) femal

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Wei, X. K., Y. Z. Zhong, Y. Pan, X. N. Li, J. J. Liang, and T. R. Luo. "The N and P genes facilitate pathogenicity of the rabies virus G gene." Veterinární Medicína 63, No. 12 (2018): 561–70. http://dx.doi.org/10.17221/63/2018-vetmed.

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To explore the effects of different gene combinations on the pathogenicity of the rabies virus (RABV), six chimeric RABV mutants, rRC-HL(G), rRC-HL(NG), rRC-HL(PG), rRC-HL(NP), rRC-HL(NM) and rRC-HL(NPG), were constructed using a reverse genetic technique based on an avirulent parental rRC-HL strain and a virulent parental GX074 isolate. These mutants were intracerebrally inoculated into adult mice. The results indicated that 10<sup>2</sup> ffu and 10<sup>6</sup> ffu of rRC-HL(G), rRC-HL(NG), rRC-HL(PG) and rRC-HL(NPG) were 100% lethal. In the case of intramuscular vira

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Cheung, Tanya T., Mitchell K. Weston, and Megan J. Wilson. "Selection and evaluation of reference genes for analysis of mouse(Mus musculus) sex-dimorphic brain development." PeerJ 5 (January 19, 2017): e2909. http://dx.doi.org/10.7717/peerj.2909.

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The development of the brain is sex-dimorphic, and as a result so are many neurological disorders. One approach for studying sex-dimorphic brain development is to measure gene expression in biological samples using RT-qPCR. However, the accuracy and consistency of this technique relies on the reference gene(s) selected. We analyzed the expression of ten reference genes in male and female samples over three stages of brain development, using popular algorithms NormFinder, GeNorm and Bestkeeper. The top ranked reference genes at each time point were further used to quantify gene expression of th

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Perera, Vindya, Harsha Samarasekara, Upamali Herath, Jayanthi Elvitigala, Shirani Chandrasiri, and Enoka Corea. "Phenotypic antimicrobial resistance associated with different <em>bla</em> genotypes and their combinations in Enterobacterales." Ceylon Medical Journal 69, SI3 (2024): 23–36. http://dx.doi.org/10.4038/cmj.v69isi3.9953.

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Introduction: Varying combinations of β-lactamase genes (bla) in Enterobacterales manifest different resistant phenotypes.Objectives: This study aimed to identify bla gene types and combinations resulting in variations in phenotypic antimicrobial resistance.Methods: Minimum inhibitory concentrations (MICs) of 75 extended spectrum β-lactamase (ESBL), AmpC β-lactamase and carbapenemase-producing Entero-bacterales isolates from a variety of clinical specimens were determined by Vitek micro-broth dilution. Bla genes were detected by 16-plex tandem PCR panel and Xpert Carba-R assay. BlaCTX-M group-

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Mundt, Christopher C. "Pyramiding for Resistance Durability: Theory and Practice." Phytopathology® 108, no. 7 (2018): 792–802. http://dx.doi.org/10.1094/phyto-12-17-0426-rvw.

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Durable disease resistance is a key component of global food security, and combining resistance genes into “pyramids” is an important way to increase durability of resistance. The mechanisms by which pyramids impart durability are not well known. The traditional view of resistance pyramids considers the use of major resistance gene (R-gene) combinations deployed against pathogens that are primarily asexual. Interestingly, published examples of the successful use of pyramids in the traditional sense are rare. In contrast, most published descriptions of durable pyramids in practice are for cerea

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Isakova, Jainagul T., E. T. Talaibekova, K. B. Makieva, D. A. Asambaeva, B. B. Sultangazieva, and A. A. Aldashev. "Association between XRCC1 ARG399GLN, TP53 ARG72PRO and MDM2 T309G polymorphisms and the risk of breast cancer in women of the Kyrgyz population." Russian Journal of Oncology 21, no. 3 (2016): 131–35. http://dx.doi.org/10.18821/1028-9984-2016-21-3-131-135.

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Aim. To study an association between Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene polymorphisms and breast cancer (BC) rate in women of the Kyrgyz population Material and Methods. Genomic DNA was obtainedfrom the whole blood of 117 breast cancer patients and 102 cancer-free healthy women residing in the Kyrgyz Republic. XRCC1 (Arg399Gln), TP53(Arg72Pro) and MDM2 (T309G) genotyping was carried out by restriction fragment length polymorphism (RFLP) assay. Results. Women with the 399Gln allele had 1,57 fold higher risk (OR=1,57; p=0,034) of developing breast cancer than c

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Farhan, Sara Mahmoud, Rehab Mahmoud Abd El-Baky, Salah Abdalla, et al. "In Vitro and in Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli." Tropical Medicine and Infectious Disease 7, no. 10 (2022): 281. http://dx.doi.org/10.3390/tropicalmed7100281.

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Introduction: The emergence of multidrug-resistant (MDR) E. coli has developed worldwide; therefore, the use of antibiotic combinations may be an effective strategy to target resistant bacteria and fight life-threatening infections. The current study was performed to evaluate the in vitro and in vivo efficacy of amikacin and imipenem alone and in combination against multidrug-resistant E. coli. Methods: The combination treatment was assessed in vitro using a checkerboard technique and time-killing curve and in vivo using a peritonitis mouse model. In resistant isolates, conventional PCR and qu

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Liu, Qiao, and Lei Xie. "TranSynergy: Mechanism-driven interpretable deep neural network for the synergistic prediction and pathway deconvolution of drug combinations." PLOS Computational Biology 17, no. 2 (2021): e1008653. http://dx.doi.org/10.1371/journal.pcbi.1008653.

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Drug combinations have demonstrated great potential in cancer treatments. They alleviate drug resistance and improve therapeutic efficacy. The fast-growing number of anti-cancer drugs has caused the experimental investigation of all drug combinations to become costly and time-consuming. Computational techniques can improve the efficiency of drug combination screening. Despite recent advances in applying machine learning to synergistic drug combination prediction, several challenges remain. First, the performance of existing methods is suboptimal. There is still much space for improvement. Seco

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Karimi, Mostafa, Arman Hasanzadeh, and Yang Shen. "Network-principled deep generative models for designing drug combinations as graph sets." Bioinformatics 36, Supplement_1 (2020): i445—i454. http://dx.doi.org/10.1093/bioinformatics/btaa317.

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Abstract Motivation Combination therapy has shown to improve therapeutic efficacy while reducing side effects. Importantly, it has become an indispensable strategy to overcome resistance in antibiotics, antimicrobials and anticancer drugs. Facing enormous chemical space and unclear design principles for small-molecule combinations, computational drug-combination design has not seen generative models to meet its potential to accelerate resistance-overcoming drug combination discovery. Results We have developed the first deep generative model for drug combination design, by jointly embedding gra

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Liu, Xuhui, Xiaoxiao Deng, Weilong Kong, Tong Sun, and Yangsheng Li. "The Pyramiding of Elite Allelic Genes Related to Grain Number Increases Grain Number per Panicle Using the Recombinant Lines Derived from Indica–japonica Cross in Rice." International Journal of Molecular Sciences 24, no. 2 (2023): 1653. http://dx.doi.org/10.3390/ijms24021653.

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Indica(xian)-japonica(geng) hybrid rice has many heterosis traits that can improve rice yield. However, the traditional hybrid technology will struggle to meet future needs for the development of higher-yield rice. Available genomics resources can be used to efficiently understand the gene-trait association trait for rice breeding. Based on the previously constructed high-density genetic map of 272 high-generation recombinant inbred lines (RILs) originating from the cross of Luohui 9 (indica, as female) and RPY geng (japonica, as male) and high-quality genomes of parents, here, we further expl

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Arumugam, S., and V. R. K. Reddy. "ROLE OF DIFFERENT GENOME COMBINATIONS ON STABILITY PARAMETERS IN WHEAT AND TRITICALE." Acta Agronomica Hungarica 49, no. 1 (2001): 53–58. http://dx.doi.org/10.1556/aagr.49.2001.1.6.

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The role of the different genome combinations in a polyploid on phenotypic stability was analysed in wheat and triticale. Twelve genotypes with four genome combinations (AABB, AABBDD, AABBRR and AABBDDRR) were raised in eight artificially created environments. The data on grains per spike, 100-grain weight and grain yield per plant were recorded and analysed following the models of Perkins and Jinks (1968) and Eberhart and Russell (1966). The results revealed that in polyploid species the genes for stability were not uniformly distributed in different genomes. It was therefore inferred that st

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Korytina, Gulnaz F., Yulia G. Aznabaeva, Timur R. Nasibullin, et al. "Gene-gene and gene-environment interactions of the inflammatory gene variants in the development of chronic obstructive pulmonary disease." Global Translational Medicine 1, no. 1 (2022): 1–14. http://dx.doi.org/10.36922/gtm.v1i1.91.

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Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that is characterized by partly reversible airflow limitation, chronic inflammation, fibrosis of small airways, and destruction of lung parenchyma. We aimed to assess the association of the inflammatory gene loci singly and in combinations with COPD in smokers and non-smokers in ethnic Tatar from Russia to evaluate the gene-gene and gene-environment interactions in COPD development. Eleven loci of inflammatory genes, including IL19, IL20, IL24, PPBP, IL4, IL4RA, С5, FAS, FASLG, and TGFb1, were genotyped in 4

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Golubkina, E. V., V. M. Sorokin, B. N. Levitan, A. R. Umerova, and N. V. Kamneva. "Genetic differences between Helicobacter pylori strains isolated from patients with chronic mild and severe gastritis." Antibiotics and Chemotherapy 66, no. 9-10 (2022): 24–29. http://dx.doi.org/10.37489/0235-2990-2021-66-9-10-24-29.

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Background. Helicobacter pylori-associated chronic gastritis (CG), being a very heterogeneous group, still does not have a divisin based on Helicobacter pylori (Hp) genotyping data, which could predict the clinical form of CG.The aim of the study is to search for the prevalence of the cagA gene or any allelic combination of the vacA gene, or stable combinations of cagA and any allelic combination of vacA genes in Hp isolates from patients with mild and severe CG, as well as patients with peptic ulcer disease (PUD).Methods. Hp isolates from gastrobiopsy specimens were genotyped for cagA and vac

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Hu, Dong-Liang, Katsuhiko Omoe, Fumio Inoue, et al. "Comparative prevalence of superantigenic toxin genes in meticillin-resistant and meticillin-susceptible Staphylococcus aureus isolates." Journal of Medical Microbiology 57, no. 9 (2008): 1106–12. http://dx.doi.org/10.1099/jmm.0.2008/002790-0.

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A total of 118 meticillin-resistant Staphylococcus aureus (MRSA) and 140 meticillin-susceptible S. aureus (MSSA) isolates from different patients in the same time period were comprehensively searched using a multiplex PCR for the classical and recently described superantigenic toxin gene family comprising the staphylococcal enterotoxin genes sea to ser and the toxic shock syndrome toxin 1 gene, tst-1. Both MRSA and MSSA isolates carried a number of superantigenic toxin genes, but the MRSA isolates harboured more superantigenic toxin genes than the MSSA isolates. The most frequent genotype of t

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Berriz, G. F., J. V. White, O. D. King, and F. P. Roth. "GoFish finds genes with combinations of Gene Ontology attributes." Bioinformatics 19, no. 6 (2003): 788–89. http://dx.doi.org/10.1093/bioinformatics/btg088.

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Meng, Bingxin, Tao Wang, Yi Luo, et al. "Identification and Allele Combination Analysis of Rice Grain Shape-Related Genes by Genome-Wide Association Study." International Journal of Molecular Sciences 23, no. 3 (2022): 1065. http://dx.doi.org/10.3390/ijms23031065.

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Grain shape is an important agronomic character of rice, which affects the appearance, processing, and the edible quality. Screening and identifying more new genes associated with grain shape is beneficial to further understanding the genetic basis of grain shape and provides more gene resources for genetic breeding. This study has a natural population containing 623 indica rice cultivars. Genome-wide association studies/GWAS of several traits related to grain shape (grain length/GL, grain width/GW, grain length to width ratio/GLWR, grain circumferences/GC, and grain size/grain area/GS) were c

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Kachnov, Vasilii A., Vadim V. Tyrenko, Svetlana N. Kolyubaeva, Lilia A. Myakoshina, and Alexandra S. Buntovskaya. "Secondary risk factors of sudden cardiac death and genes of arterial hypertension." HERALD of North-Western State Medical University named after I.I. Mechnikov 12, no. 3 (2020): 27–34. http://dx.doi.org/10.17816/mechnikov34642.

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Purpose. To study the influence of polymorphisms of arterial hypertension genes and their various combinations on individual risk factors of sudden cardiac death. Materials and methods. 319 young people from 18 to 24 years of age who are entering military service by conscription were examined. The survey identified 69 individuals with signs of increased risk of sudden cardiac death after being examined for secondary risk factors of sudden cardiac death and taken a blood test to determine the polymorphisms of the genes AGT 521 CT, GNB3 825 CT, CYP11B2 344 CT, NOS3 786 TC. Results. T

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Šliková, S., E. Gregová, P. Bartoš, A. Hanzalová, M. Hudcovicová, and J. Kraic. "Development of wheat genotypes possessing a combination of leaf rust resistance genes Lr19 and Lr24." Plant, Soil and Environment 50, No. 10 (2011): 434–38. http://dx.doi.org/10.17221/4055-pse.

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Endopeptidase allele Ep-D1c and DNA marker-assisted selection have been used for the incorporation of Lr19 + Lr24&nbsp;leaf rust resistance genes combination into adapted commercial winter wheat cultivars. The first step was the transfer of the gene Lr19 from the donor cultivar Agrus into acceptor cultivars Simona and L&iacute;via. The progenies possessing the null allele Ep-D1c linked to the gene Lr19 have been screened for their resistance to leaf rust by isolate 4332 SaBa. The plants homozygous properties at the Ep-D1c locus and resistant against leaf rust were used for crossing wit

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Beh, Christopher T., Laurence Cool, John Phillips, and Jasper Rine. "Overlapping Functions of the Yeast Oxysterol-Binding Protein Homologues." Genetics 157, no. 3 (2001): 1117–40. http://dx.doi.org/10.1093/genetics/157.3.1117.

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Abstract The Saccharomyces cerevisiae genome encodes seven homologues of the mammalian oxysterol-binding protein (OSBP), a protein implicated in lipid trafficking and sterol homeostasis. To determine the functions of the yeast OSBP gene family (OSH1-OSH7), we used a combination of genetics, genomics, and sterol lipid analysis to characterize OSH deletion mutants. All 127 combinations and permutations of OSH deletion alleles were constructed. Individual OSH genes were not essential for yeast viability, but the elimination of the entire gene family was lethal. Thus, the family members shared an

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Holdorf, Amy D., Daniel P. Higgins, Anne C. Hart, et al. "WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data." Genetics 214, no. 2 (2019): 279–94. http://dx.doi.org/10.1534/genetics.119.302919.

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The emergence of large gene expression datasets has revealed the need for improved tools to identify enriched gene categories and visualize enrichment patterns. While gene ontogeny (GO) provides a valuable tool for gene set enrichment analysis, it has several limitations. First, it is difficult to graph multiple GO analyses for comparison. Second, genes from some model systems are not well represented. For example, ∼30% of Caenorhabditis elegans genes are missing from the analysis in commonly used databases. To allow categorization and visualization of enriched C. elegans gene sets in differen

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Kousik, C. S., and D. F. Ritchie. "Response of Bell Pepper Cultivars to Bacterial Spot Pathogen Races that Individually Overcome Major Resistance Genes." Plant Disease 82, no. 2 (1998): 181–86. http://dx.doi.org/10.1094/pdis.1998.82.2.181.

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The effect of major resistance genes (Bs1, Bs2, and Bs3) or gene combinations for resistance to bacterial spot of bell peppers (Xanthomonas campestris pv. vesicatoria) in 15 commercial cultivars on disease reduction and yield were studied during 1995 and 1996. Reaction of cultivars to specific races (races 1, 2, or 3) of the pathogen corresponded with seed company claims for resistance against these races. Races 1 to 4 were used as initial inoculum in 1995, and races 1 to 6 in 1996 field experiments. Cultivars with no known resistance genes to bacterial spot (e.g., Camelot, Jupiter, and Valian

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Oudejans, Rob C. H. M. "New combinations for infraspecific taxa in the genus Euphorbia L. (Euphorbiaceae)." Collectanea Botanica 21 (December 30, 1992): 183–89. http://dx.doi.org/10.3989/collectbot.1992.v21.99.

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Fodstad, O., Y. Xi, K. Risberg, J. Ju, and Y. G. Anderson. "Synergistic antitumor efficacy and altered gene expression signature in breast cancer cells treated with immunotoxins and cyclosporin A." Journal of Clinical Oncology 25, no. 18_suppl (2007): 13505. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.13505.

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13505 Background: Immunotoxins (ITs) has shown limited clinical success related to liver toxicity and development of anti-IT antibodies. To delay the immune response we tested combinations of ITs and the Cyclosporin A (CsA). we have shown that one IT, currently in a phase I/II clinical trial, acts by inducing apoptosis and protein synthesis inhibition, but gene expression analysis of IT treated cells has never been reported. Hence, we also studied changes in gene expression induced by ITs alone and the effects of adding (CsA) on both treatment efficacy and gene expression signature. Methods: H

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Cheriyath, V., K. B. Glaser, C. Healan-Greenberg, J. F. Waring, M. Kalaycio та E. C. Borden. "Epigenetic regulation of IFN-α2b in multiple myeloma by a hydroxamic acid histone deacetylase (HDAC) inhibitor (SAHA) and a non-hydroxamic acid HDAC inhibitor (A-423378)". Journal of Clinical Oncology 25, № 18_suppl (2007): 14048. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14048.

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14048 Background: Full clinical potential of IFN-a2b is yet to be achieved in multiple myeloma. Although IFN-a2b leads to the induction of pro-apoptotic interferon stimulated genes (ISGs) (>100 fold) in myeloma cells, <20% of cells underwent apoptosis. Thus, we hypothesized that epigenetic silencing of ISGs may be responsible for the sub-optimal cellular response of myeloma to IFNs. Re-expression of suppressed ISGs by inhibiting HDACs could enhance IFNs effects. Methods: Myeloma cell lines NCI H929, RPMI 8266 and U266 treated for 96 hr with increasing concentrations of SAHA (Suberoyl Ani

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Pradhan, Sharat Kumar, Deepak Kumar Nayak, Elssa Pandit, et al. "Incorporation of Bacterial Blight Resistance Genes Into Lowland Rice Cultivar Through Marker-Assisted Backcross Breeding." Phytopathology® 106, no. 7 (2016): 710–18. http://dx.doi.org/10.1094/phyto-09-15-0226-r.

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Bacterial blight (BB) of rice caused by Xanthomonas oryzae pv. oryzae is a major disease of rice in many rice growing countries. Pyramided lines carrying two BB resistance gene combinations (Xa21+xa13 and Xa21+xa5) were developed in a lowland cultivar Jalmagna background through backcross breeding by integrating molecular markers. In each backcross generation, markers closely linked to the disease resistance genes were used to select plants possessing the target genes. Background selection was continued in those plants carrying resistant genes until BC3 generation. Plants having the maximum co

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Ahmed, Hafiz U., Maria R. Finckh, Rizal F. Alfonso, and Christopher C. Mundt. "Epidemiological Effect of Gene Deployment Strategies on Bacterial Blight of Rice." Phytopathology® 87, no. 1 (1997): 66–70. http://dx.doi.org/10.1094/phyto.1997.87.1.66.

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Experiments were conducted in farmers' fields at two locations of the irrigated lowlands of Laguna province in southern Luzon island, Philippines, during the wet seasons of 1993 and 1994. Nine rice populations were studied including pure stands, two-component mixtures, two-gene combinations of backcrossed lines containing varying combinations of the bacterial blight resistance genes Xa-4, xa-5, and Xa-10, and a non-isogenic cultivar containing Xa-4 and partial resistance to bacterial blight. The area under the disease progress curve (AUDPC) of both gene combinations studied was significantly l

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Samatoshenkov, Igor Valerievich, Alexander Maazovich Aimaletdinov, Elena Yurievna Zakirova, et al. "The Combined Delivery of the Vegf, Ang, and Gdnf Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle." Current Issues in Molecular Biology 46, no. 8 (2024): 8611–26. http://dx.doi.org/10.3390/cimb46080507.

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In this study, the effects of different combinations of the genes Vegf, Ang, and Gdnf injected both using direct virus-mediated injection (adenovirus, Ad5) and umbilical cord blood mononuclear cells (UCBCs) on the processes of stimulation of post-ischemic innervation, angiogenesis, and regeneration in skeletal muscle were investigated in a rat hindlimb chronic ischemia model. It was shown that more pronounced stimulation of angiogenesis and restoration of post-ischemic innervation were achieved both in the early (28 days post-ischemia, dpi) and late (42 dpi) terms of the experiment in the calf

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Gordon, S. G., S. A. Berry, S. K. St. Martin, and A. E. Dorrance. "Genetic Analysis of Soybean Plant Introductions with Resistance to Phytophthora sojae." Phytopathology® 97, no. 1 (2007): 106–12. http://dx.doi.org/10.1094/phyto-97-0106.

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Phytophthora sojae, which causes Phytophthora root and stem rot of soybean, is a serious disease worldwide and is managed primarily by deploying cultivars with resistance. Thirty-two soybean plant introductions (PIs), all but three of which were from South Korea, were proposed as new sources of single-gene resistance to P. sojae. The objective of this study was to characterize the inheritance of resistance to P. sojae in these PIs. Twenty-two soybean populations from crosses of these PIs and the susceptible cv. Williams were inoculated with P. sojae OH17 (vir 1b, 1d, 2, 3a, 3b, 3c, 4, 5, 6, 7)

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Pan, Yang, Yue Zhao, Hua-Rui Zeng, et al. "Reference Genes for Expression Analyses by qRT-PCR in Enterobacter cancerogenus." Microorganisms 12, no. 5 (2024): 1024. http://dx.doi.org/10.3390/microorganisms12051024.

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The Enterobacter cancerogenus strain EcHa1 was isolated from the dead larvae of Helicoverpa armigera, and has the potential for biocontrol of some Lepidoptera insects. In order to screen insecticidal-related genes by qRT-PCR, stable endogenous reference genes used for normalizing qRT-PCR data were selected and evaluated from 13 housekeeping genes (HKGs). The expression levels of the HKGs were determined using qRT-PCR under different experimental conditions, including two culture temperatures and three bacterial OD values. Five stability analysis methods (Ct, BestKeeper, NormFinder, geNorm, and

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Fu, Yepei, Jia Yang, Shanshan Fan, et al. "A Novel Strategy Facilitates Reference Gene Selection by RT-qPCR Analysis in Kidney Yang Deficiency Syndrome Mice Infected with the Influenza A (H1N1) Virus." BioMed Research International 2020 (April 27, 2020): 1–11. http://dx.doi.org/10.1155/2020/9075165.

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In reverse transcription-quantitative polymerase chain reaction (RT-qPCR) studies, endogenous reference genes are routinely used to normalize the expression of target gene studies. In order to precisely evaluate the relative expression of genes in the cells of mice suffering from Kidney Yang Deficiency Syndrome (KYDS) in response to influenza A virus (IAV) H1N1 using RT-qPCR, it is crucial to identify reliable reference genes. In the present study, 15 candidate reference genes (Actb, β2m, Gapdh, Gusb, Tuba, Grcc10, Eif4h, Rnf187, Nedd8, Ywhae, 18S rRNA, Rpl13, Ubc, Rpl32, and Ppia) were invest

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Guerra-Ávila, Paloma Lucía, Tereso J. Guzmán, José Alfredo Domínguez-Rosales, et al. "Combined Gamma Conglutin and Lupanine Treatment Exhibits In Vivo an Enhanced Antidiabetic Effect by Modulating the Liver Gene Expression Profile." Pharmaceuticals 16, no. 1 (2023): 117. http://dx.doi.org/10.3390/ph16010117.

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Previous studies have individually shown the antidiabetic potential of gamma conglutin (Cγ) and lupanine from lupins. Until now, the influence of combining both compounds and the effective dose of the combination have not been assessed. Moreover, the resulting gene expression profile from this novel combination remains to be explored. Therefore, we aimed to evaluate different dose combinations of Cγ and lupanine by the oral glucose tolerance test (OGTT) to identify the higher antidiabetic effect on a T2D rat model. Later, we administered the selected dose combination during a week. Lastly, we

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Takeshima, Hideyuki, Yui Ohashi, Ryoma Mashiko, and Toshikazu Ushijima. "Abstract LB310: Methylation synthetic lethality: SMARCA1 methylation and inhibition of pyrimidine synthesis." Cancer Research 85, no. 8_Supplement_2 (2025): LB310. https://doi.org/10.1158/1538-7445.am2025-lb310.

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Abstract Synthetic lethality is a promising therapeutic strategy, but the number of combinations of a mutated gene and a therapeutic target gene is limited. In contrast with a mutation, DNA methylation is frequently present in many types of cancers, and can be a rich source for a synthetic lethality. So far, BRCA1 methylation with a PARP inhibitor is known as a synthetic lethality [Kawachi et al., Breast Cancer Res Treat, 181:323-329, 2020]. We have been searching to identify a novel synthetic lethal combinations by using methylated genes. In this study, as a methylated gene, we focused on SMA

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Yee, Jaeyong, and Mira Park. "Deep Learning Identification of the Gene-Gene Interactions without the Need of thorough Investigation of Each Genomic Combination." Korean Data Analysis Society 19, no. 5 (2017): 2277–85. http://dx.doi.org/10.37727/jkdas.2017.19.5.2277.

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Downey-Kopyscinski, Sondra L., Ricardo De Matos Simoes, Ryosuke Shirasaki, et al. "Functional Interactions between Transcription Factors Involved in Myeloma Pathogenesis - Biological and Therapeutic Implications." Blood 134, Supplement_1 (2019): 315. http://dx.doi.org/10.1182/blood-2019-127502.

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The clinical success of combination therapies for multiple myeloma (MM) has led our group and others to perform pharmacological screens seeking to identify promising candidates for combination regimens. However, in our genome-scale CRISPR knockout (KO) studies, we have observed that the biological behavior of MM cells is driven by key transcription factors (TFs), including several that represent major preferential dependencies for MM cells compared to other blood cancers or to solid tumors. Most of these TFs are currently considered "undruggable", as they lack identifiable hydrophobic pockets

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Zhou, Yuanjie, Hui Xia, Xinling Liu, et al. "Identification of Suitable Reference Genes for qRT-PCR Normalization in Kiwifruit." Horticulturae 8, no. 2 (2022): 170. http://dx.doi.org/10.3390/horticulturae8020170.

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Reference genes are used for the correction of qRT-PCR data, and it is necessary to investigate the optimum reference gene under certain conditions. The expression levels of seven traditional reference genes ACT1, ACT2, GAPDH, 18S rRNA, UBQ, TUB and CYP were analyzed using qRT-PCR in different varieties, tissues, developmental stages and hormone (or pollen polysaccharide) treatments in kiwifruit. Gene expression stability was assessed with the help of three common software (geNorm, NormFinder, BestKeeper), and the minimum number of reference genes necessary for normalization was also determine

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Gultyaeva, Elena I., Ekaterina R. Shreyder, Igor’ Yu Kushnirenko, Ekaterina L. Shaydayuk, and Nadezhda M. Kovalenko. "Evaluation of advanced bread spring wheat lines for field and seedling resistance to foliar pathogens." BIO Web of Conferences 23 (2020): 01005. http://dx.doi.org/10.1051/bioconf/20202301005.

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Foliar diseases (rusts and blotches) significantly limit the yield of spring wheat in the Southern Urals. The aim of the research was a comprehensive assessment of 17 promising lines of bread spring wheat, created at the Chelyabinsk Research Institute of Agriculture, for disease resistance and their identification of Lr genes. Resistance to leaf and stem rusts, Paraganospora nodorum leaf blotch and tan spot was studied in the field and laboratory conditions. All studied lines were characterized by high level of resistance to leaf and stem rusts in the seedling and adult plant stages. A wide re

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