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Journal articles on the topic 'Genuine variant'

Author: Grafiati
Published: 10 September 2021
Last updated: 29 July 2025

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1

NEER, TRAPTI, ANA MARIA ACU, and P. N. AGRAWAL. "Bezier variant of genuine-Durrmeyer type operators based on Polya distribution." Carpathian Journal of Mathematics 33, no. 1 (2017): 73–86. http://dx.doi.org/10.37193/cjm.2017.01.08.

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In this paper we introduce the Bezier variant of genuine-Durrmeyer type operators having Polya basis functions. We give a global approximation theorem in terms of second order modulus of continuity, a direct approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem by using the Ditzian-Totik modulus of smoothness. The rate of convergence for functions whose derivatives are of bounded variation is obtained. Further, we show the rate of convergence of these operators to certain functions by illustrative graphics using the Maple algorithms.
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2

Gori, Franco, and Massimo Santarsiero. "Variant-Coherence Gaussian Sources." Photonics 8, no. 9 (2021): 403. http://dx.doi.org/10.3390/photonics8090403.

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The celebrated Gaussian Schell model source with its shift-invariant degree of coherence may be the basis for devising sources with space-variant properties in the spirit of structured coherence. Starting from superpositions of Gaussian Schell model sources, we present two classes of genuine cross-spectral densities whose degree of coherence varies across the source area. The first class is based on the use of the Laplace transform while the second deals with cross-spectral densities that are shape-invariant upon paraxial propagation. For the latter, we present a set of shape-invariant cross-s
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3

Walter, Alex. "Biology and social life: book review/Biologie et vie sociale: note de lecture: The trouble with memes: deconstructing Dawkins's monster." Social Science Information 46, no. 4 (2007): 691–709. http://dx.doi.org/10.1177/0539018407082597.

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The essay explores the adequacy of the `meme' concept to explain the basic mechanism of cultural evolution. Distin's defense of `memetics' is deficient because it is based on a flawed analogy with genetics. Although Richerson and Boyd's `cultural variant' is not based on a flawed analogy with genetics, their alternative appears primarily to be operant conditioning in disguise and presents no novel innovations in learning theory. Both models of gene—culture co-evolution are examples of one-sided cultural determinism with no genuine biological component. Analysis of the information metaphysics o
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4

Heupink, Tim H., Lennert Verboven, Abhinav Sharma, et al. "The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples." PLOS Computational Biology 19, no. 11 (2023): e1011648. http://dx.doi.org/10.1371/journal.pcbi.1011648.

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Background Whole genome sequencing (WGS) holds great potential for the management and control of tuberculosis. Accurate analysis of samples with low mycobacterial burden, which are characterized by low (<20x) coverage and high (>40%) levels of contamination, is challenging. We created the MAGMA (Maximum Accessible Genome for Mtb Analysis) bioinformatics pipeline for analysis of clinical Mtb samples. Methods and results High accuracy variant calling is achieved by using a long seedlength during read mapping to filter out contaminants, variant quality score recalibration with machine learn
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Romano, Marta M. M. "Il grano antico Tumminia: storia di un termine e dei suoi diversi usi mediterranei." Rivista di Storia dell'Agricoltura, no. 155 (January 31, 2023): 5–37. http://dx.doi.org/10.35948/0557-1359/2023.2350.

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RiassuntoIl seme chiamato Tumminia è uno dei grani antichi più cari al Mediterraneo per le sue peculiarità: pur interrato nei mesi primaverili, giunge a maturazione insieme agli altri e con la sua farina si impasta un genuino pane nero. La denominazione corrente, nelle diverse varianti quali Timilia/Tremenia/Tumonia e altre, rimonta non a un grano duro bensì a cereali di più antica tradizione e uso, menzionati già da Teofrasto e Columella; passa poi attraverso lo spagnolo tremesino, il francese tramois e l’arabo tharmi
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Sigley, Sarah, and Olaf Beyersdorff. "Proof Complexity of Modal Resolution." Journal of Automated Reasoning 66, no. 1 (2021): 1–41. http://dx.doi.org/10.1007/s10817-021-09609-9.

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AbstractWe investigate the proof complexity of modal resolution systems developed by Nalon and Dixon (J Algorithms 62(3–4):117–134, 2007) and Nalon et al. (in: Automated reasoning with analytic Tableaux and related methods—24th international conference, (TABLEAUX’15), pp 185–200, 2015), which form the basis of modal theorem proving (Nalon et al., in: Proceedings of the twenty-sixth international joint conference on artificial intelligence (IJCAI’17), pp 4919–4923, 2017). We complement these calculi by a new tighter variant and show that proofs can be efficiently translated between all these va
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Kos, M., S. Denger, G. Reid, KS Korach, and F. Gannon. "Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse." Journal of Molecular Endocrinology 29, no. 3 (2002): 281–86. http://dx.doi.org/10.1677/jme.0.0290281.

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The mouse knockout of the estrogen receptor alpha (ERalpha) gene, known as alphaERKO, has been extensively used for several years to study the role and function of ERalpha. Residual estradiol binding capacity in uterine tissue of 5-10% raised doubts if this knockout is a genuine null mutation of ERalpha. Although alternatively spliced ERalpha mRNA variants in the alphaERKO mouse were reported previously, the corresponding protein isoforms have not been detected to date. Here we show that a variant ERalpha protein, 61 kDa in size, is expressed in the uterine tissue of alphaERKO mice as a result
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8

Di, Yunyun, Jocelyne Lew, Una Goncin, et al. "SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model." Viruses 14, no. 10 (2022): 2272. http://dx.doi.org/10.3390/v14102272.

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Small animal models that accurately model pathogenesis of SARS-CoV-2 variants are required for ongoing research efforts. We modified our human immune system mouse model to support replication of SARS-CoV-2 by implantation of human lung tissue into the mice to create TKO-BLT-Lung (L) mice and compared infection with two different variants in a humanized lung model. Infection of TKO-BLT-L mice with SARS-CoV-2 recapitulated the higher infectivity of the B.1.1.7 variant with more animals becoming infected and higher sustained viral loads compared to mice challenged with an early B lineage (614D) v
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Gangwar, Rajeev, Tanmoy Pandit, Kaumudibikash Goswami, Siddhartha Das, and Manabendra Nath Bera. "Squashed quantum non-Markovianity: a measure of genuine quantum non-Markovianity in states." Quantum 9 (February 26, 2025): 1646. https://doi.org/10.22331/q-2025-02-26-1646.

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Quantum non-Markovianity in tripartite quantum states ρABC represents a correlation between systems A and C when conditioned on the system B and is known to have both classical and quantum contributions. However, a systematic characterization of the latter is missing. To address this, we propose a faithful measure for non-Markovianity of genuine quantum origin called squashed quantum non-Markovianity (sQNM). It is based on the quantum conditional mutual information and is defined by the left-over non-Markovianity after squashing out all non-quantum contributions. It is lower bounded
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10

Lurie, Peter. "Trials for second generation Covid-19 vaccines: Revisiting the debate over placebo use in developing country clinical trials." Indian Journal of Medical Ethics 06, no. 02 (2021): 113–17. http://dx.doi.org/10.20529/ijme.2021.023.

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This article compares the current debate over the use of placebos in developing country clinical trials of second generation Covid-19 vaccines with the debates over previous paradigmatic cases raising similar issues. Compared to the earlier zidovudine and Surfaxin trials, Covid-19 vaccine trials are likely to confer lower risk to placebo groups and to offer a greater number and variety of alternative study designs. However, turning to the developing world to conduct studies that would be unacceptable in developed countries, simply on the ground that Covid-19 vaccines are generally unavailable
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11

Starovoitov, V. V. "Verification of normalized online signatures without calculating dynamic features." Informatics 21, no. 4 (2024): 72–84. https://doi.org/10.37661/1816-0301-2024-21-4-72-84.

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Objectives. Study of the method of verification of the authenticity of a human signature made on a tablet with a stylus and given three parameters: coordinates X, Y and pressure on the tablet P.Methods. N genuine dynamic human signatures are given. Data describing different signatures made by one person always have a different number of points. The main variants of normalization of the original signature data are investigated. A model of an individual image of human signatures is built without calculating dynamic features. The method of dynamic time transformation (DTW) is used to compare simi
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12

IV, Milo W. Hyde. "Synthesizing General Electromagnetic Partially Coherent Sources from Random, Correlated Complex Screens." Optics 1, no. 1 (2020): 97–113. http://dx.doi.org/10.3390/opt1010008.

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We present a method to generate any genuine electromagnetic partially coherent source (PCS) from correlated, stochastic complex screens. The method described here can be directly implemented on existing spatial-light-modulator-based vector beam generators and can be used in any application which utilizes electromagnetic PCSs. Our method is based on the genuine cross-spectral density matrix criterion. Applying that criterion, we show that stochastic vector field realizations (corresponding to a desired electromagnetic PCS) can be generated by passing correlated Gaussian random numbers through “
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13

Wiegel, Narine, Valentina Chernikova, Elena Sergodeeva, and Ivan Gulyak. "The concept “freedom” in a virtual reality of the information society." SHS Web of Conferences 72 (2019): 03003. http://dx.doi.org/10.1051/shsconf/20197203003.

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In the article he authors analyze the key aspects of the crisis of western culture which are revealed in the formation of “civilization of consumption” and create limitation of freedom which has a variant of value orientations choice. At the same time the contradiction between traditional and global value dominants appears and here due to freedom of choice ethical guidelines become situational ones, satisfying utilitarian aims. There appears a condition of instability, leading to “social loneliness”. The only way out for a man is an “imaginable world of a dream”, a virtual reality based on inf
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14

Vecellio Reane, Denis, Cristina Cerqua, Sabrina Sacconi, Leonardo Salviati, Eva Trevisson, and Anna Raffaello. "The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation." International Journal of Molecular Sciences 23, no. 5 (2022): 2517. http://dx.doi.org/10.3390/ijms23052517.

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Alternative splicing, the process by which exons within a pre-mRNA transcript are differentially joined or skipped, is crucial in skeletal muscle since it is required both during myogenesis and in post-natal life to reprogram the transcripts of contractile proteins, metabolic enzymes, and transcription factors in functionally distinct muscle fiber types. The importance of such events is underlined by the numerosity of pathological conditions caused by alternative splicing aberrations. Importantly, many skeletal muscle Ca2+ homeostasis genes are also regulated by alternative splicing mechanisms
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15

Lwi, Sandy J., James J. Casey, Alice Verstaen, Dyan E. Connelly, Jennifer Merrilees, and Robert W. Levenson. "Genuine Smiles by Patients During Marital Interactions are Associated with Better Caregiver Mental Health." Journals of Gerontology: Series B 74, no. 6 (2018): 975–87. http://dx.doi.org/10.1093/geronb/gbx157.

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Abstract Objective Providing care for a spouse with dementia is associated with an increased risk for poor mental health. To determine whether this vulnerability in caregivers is related to the expression of positive emotion, we examined 57 patients with Alzheimer’s disease and behavioral variant frontotemporal dementia and their spouses as they discussed a marital conflict. Method Facial behavior during the discussion was objectively coded to identify Duchenne (i.e., genuine) smiles and non-Duchenne (i.e., polite) smiles. Caregiver mental health was measured using the Medical Outcomes Survey.
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16

Bakhtiyarova, Muniba. "THE CORPUS-BASED APPROACH: ENHANCING LANGUAGE LEARNING THROUGH AUTHENTIC RESOURCES." Modern Scientific Research International Scientific Journal 1, no. 8 (2023): 107–9. https://doi.org/10.5281/zenodo.10092230.

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This article explores the significance of the corpus-based approach in language learning and teaching. It discusses the concept of a corpus as a collection of authentic texts that represents a language or linguistic variant. The corpus-based approach focuses on utilizing these texts to provide learners with genuine language examples and patterns. The article also highlights the impact of corpus linguistics on learner autonomy and the development of authentic teaching resources. It emphasizes the role of the corpus-based approach in addressing specific language learning needs, such as improving
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17

Bohdan, Svitlana. "About «Тілько» and not only in Lesіa Ukrainka’s language creation: in search of idiosyncrasy". Culture of the Word, № 93 (2020): 100–114. http://dx.doi.org/10.37919/0201-419x-2020.93.8.

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The article elucidates the regularities of the use and functioning features of the lexemes til’ko and til’ky in Lesya Ukrainka’s autographs and published epistolary and poetic texts. The study, using the comparative analysis approach, proves that both lexemes have the status of variants and are fixed in the similar semantic contexts. The actualization of the lexemes in the usus of the Ukrainian language confirms that they are polysemantic by nature and grammatically heterogeneous. The case study has revealed a clear quantitative dominance of using the variant til’ko in autographs. But the form
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18

Kochar Kaur, Kulvinder, Gautam Allahbadia, and Mandeep Singh. "Validation of the existence of genuine Empty follicle syndrome, versus false empty follicle syndrome to make definitive decisions in cases where recurrent IVF failure encountered secondary to absence of oocytes on ovum pick up-a short communication." International Journal of Pregnancy & Child Birth 7, no. 4 (2021): 115–17. http://dx.doi.org/10.15406/ipcb.2021.07.00239.

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Aim: Worldwide a big altercation exists with regards to the actual existence of the term “ Empty follicle syndrome’’(EFS), so much so that certain big authorities in the field have been believing that true EFS does not exist. Basically EFS is a syndrome when no functionally intact oocyte get retrieved when attempting an oocyte pick up (OPU) for a successful in vitro fertilization (IVF), however such patients encounter recurrent IVF failures. Since it is has become a big problem for the treating reproductive endocrinologist, besides the patient encountering recurrent IVF failures, it has become
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19

Groenewoud, David, Avinoam Shye, and Ran Elkon. "Incorporating regulatory interactions into gene-set analyses for GWAS data: A controlled analysis with the MAGMA tool." PLOS Computational Biology 18, no. 3 (2022): e1009908. http://dx.doi.org/10.1371/journal.pcbi.1009908.

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To date, genome-wide association studies have identified thousands of statistically-significant associations between genetic variants, and phenotypes related to a myriad of traits and diseases. A key goal for human-genetics research is to translate these associations into functional mechanisms. Popular gene-set analysis tools, like MAGMA, map variants to genes they might affect, and then integrate genome-wide association study data (that is, variant-level associations for a phenotype) to score genes for association with a phenotype. Gene scores are subsequently used in competitive gene-set ana
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Almeida, J. Traça, J. Alves da Silva, M. Xavier, and R. Gusmão. "is Feigned Psychosis a Pathway to Schizophrenia?" European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71344-6.

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Factitious disorders (FD) are characterized by intentional production of either physical, psychological or mixed symptoms that mimic various clinical syndromes, with no apparent advantage for the individual concerned other than allowing him to assume the sick role. Large body of work has been accumulated on FD, but the majority of published data deal with the physical variant of the disease, with comparable few reports on psychiatric FD. Although there are many different presentations for psychiatric FD, the factitious psychosis subset justifies particular attention. Factitious psychosis may b
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Yuy, Cyan'lun. "Dance Education in China (Between Traditional and International Aspects of Development)." Scientific Research and Development. Socio-Humanitarian Research and Technology 12, no. 3 (2023): 100–106. http://dx.doi.org/10.12737/2306-1731-2023-12-3-100-106.

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The Chinese nation has a long tradition of dance education. Dance as a direction of art education integrates various aspects of personality development. Therefore, dance courses at colleges and universities have become popular among students in China. The courses help to improve body shape, develop temperament and contribute to the comprehensive development of students. Therefore, the Chinese government has always supported and developed dance education.
 This article reviews the main aspects influencing the further development of dance education, in which various conflicting processes ca
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Vasko, VV, J. Gaudart, C. Allasia, et al. "Thyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma." European Journal of Endocrinology 151, no. 6 (2004): 779–86. http://dx.doi.org/10.1530/eje.0.1510779.

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Thyroid follicular adenomas (FA) are encapsulated tumors lacking vascular, capsular or lymphatic invasion and the typical nuclear features of papillary carcinoma (PC). However, some FA demonstrate nuclear atypia reminiscent of either follicular carcinomas (FC) or follicular variant of papillary carcinomas (FVPC), suggesting they may represent precursors of malignant transformation. We hypothesized that an objective evaluation of nuclear chromatin patterns could be used to define atypical follicular tumors (AFT) that are likely to be premalignant. To test this hypothesis, we used a computer-aid
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Ribeiro, Gustavo Lins. "What's in a copy?" Vibrant: Virtual Brazilian Anthropology 10, no. 1 (2013): 20–39. http://dx.doi.org/10.1590/s1809-43412013000100001.

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I will answer the question "What's in a copy?" by considering three sets of related issues: the importance of copies in academia; in cultural life; and in the economic world. In academia the current capability of making copies is challenging pedagogical practices and the trust of its members, plagiarism being the most immediate problem. The notion of authorship is also undergoing changes provoked by a proliferation of authors and new possibilities opened up by cyberspace. In cultural life, imitation and mimesis have long been fundamental engines of socialization. Our enhanced capacity of copyi
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SINOQUET, CHRISTINE. "ITERATIVE TWO-PASS ALGORITHM FOR MISSING DATA IMPUTATION IN SNP ARRAYS." Journal of Bioinformatics and Computational Biology 07, no. 05 (2009): 833–52. http://dx.doi.org/10.1142/s0219720009004357.

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Though nowadays high-throughput genotyping techniques' quality improves, missing data still remains fairly common. Studies have shown that even a low percentage of missing SNPs is detrimental to the reliability of down-stream analyses such as SNP-disease association tests. This paper investigates the potentiality for improving the accuracy of an SNP inference method based on the algorithm formerly designed by Roberts and co-workers (NPUTE, 2007). This initial algorithm performs a single scan of an SNP array, inferring missing SNPs in the context of sliding windows. We have first designed a var
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25

Agaimy, Abbas, Leora Witkowski, Robert Stoehr, et al. "Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations—is the term “thyroblastoma” more appropriate?" Virchows Archiv 477, no. 6 (2020): 787–98. http://dx.doi.org/10.1007/s00428-020-02853-1.

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AbstractPrimary thyroid teratomas are exceedingly rare. Mature and immature variants recapitulate their gonadal counterparts (predilection for infants/children, triphasic germ layer differentiation, and favorable outcome). On the other hand, the so-called malignant teratomas affect predominantly adults and elderly, are highly aggressive, and, according to a few published cases, harbor DICER1 mutations. We describe three highly aggressive sporadic malignant teratoid thyroid tumors in 2 females (17 and 45 years) and one male (17 years). Histology showed triphasic neoplasms composed of solid nest
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Kampa-Schittenhelm, Kerstin M., Barbara Illing, Figen Akmut, Michael Walter, Charles D. Lopez, and Marcus M. Schittenhelm. "Identification Of C-Terminal Truncated Splice Variants Of The Apoptosis-Stimulating Protein Of p53-2 (ASPP2) In Acute Leukemia Lacking The p53-Binding Site." Blood 122, no. 21 (2013): 1270. http://dx.doi.org/10.1182/blood.v122.21.1270.1270.

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Abstract Apoptosis seems to be a major means by which p53 suppresses tumorigenesis in hematopoietic cells. While loss-of-function mutations in p53 are frequently found in most neoplasms, non-complex karyotype acute leukemias are typically p53 wildtype and the p53-pathways are thought to be compromised through other mechanisms. ASPP2 is an independent haploinsufficient tumor suppressor which initiates induction of apoptosis after cellular damage in a p53 dependent manner (Kampa et al., PNAS 2009). We and others have found that attenuation/loss of ASPP2 is a common event in tumors. Here we repor
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Al-Kafaji, Ghada, Materah Salem Alwehaidah, Manahel Mahmood Alsabbagh, Maram A. Alharbi, and Moiz Bakhiet. "Mitochondrial DNA haplogroup analysis in Saudi Arab patients with multiple sclerosis." PLOS ONE 17, no. 12 (2022): e0279237. http://dx.doi.org/10.1371/journal.pone.0279237.

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Previous studies have suggested that mitochondrial DNA (mtDNA) variants are associated with multiple sclerosis (MS), a complex neurodegenerative immune-mediated disease of the central nervous system. Since mtDNA is maternally inherited without recombination, specific mtDNA variants defining genetic background are associated with the susceptibility to human diseases. To assess the contribution of mtDNA haplogroups to the predisposition of MS in an Arab population, we analysed sequencing data of mitochondrial genomes from 47 native Saudi Arab individuals including 23 patients with relapsing-remi
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Choi, Hyeong In, Sungjin Lee, Hwan Pyo Moon, Nam-Sook Wee, Daehoon Kim, and Song-Hwa Kwon. "Seeded Ising Model and Distributed Biometric Template Storage and Matching." Entropy 23, no. 7 (2021): 849. http://dx.doi.org/10.3390/e23070849.

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It is known that a variant of Ising model, called Seeded Ising Model, can be used to recover the information content of a biometric template from a fraction of information therein. The method consists in reconstructing the whole template, which is called the intruder template in this paper, using only a small portion of the given template, a partial template. This reconstruction method may pose a security threat to the integrity of a biometric identity management system. In this paper, based on the Seeded Ising Model, we present a systematic analysis of the possible security breach and its pro
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Zaliova, Marketa, Claus Meyer, Gunnar Cario, et al. "The Central Region of TEL (ETV6) Is Dispensable for the TEL/AML1 (ETV6/RUNX1) Leukemogenesis." Blood 114, no. 22 (2009): 1601. http://dx.doi.org/10.1182/blood.v114.22.1601.1601.

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Abstract Abstract 1601 Poster Board I-627 TEL/AML1 (ETV6/RUNX1) fusion gene, the most frequent genetic abnormality of childhood ALL, usually results from genomic breakpoint in TEL intron 5 and AML1 introns 1 or 2 (“classical” TEL/AML1). At the protein level the helix-loop-helix domain and exon 5 coded corepressor domain of TEL are typically fused to almost entire AML1 including transactivation and DNA binding domains. TEL/AML1 fusion as a single event does not lead to leukemia development but induces a preleukemic state characterized by expansion of B-cell precursors with enhanced self-renewal
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Rushdi, Ali Muhammad Ali. "Utilization of Karnaugh Maps in Multi-Value Qualitative Comparative Analysis." International Journal of Mathematical, Engineering and Management Sciences 3, no. 1 (2018): 28–46. http://dx.doi.org/10.33889/ijmems.2018.3.1-004.

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A recent debate in the literature of Qualitative Comparative Analysis (QCA) concerns the potentials and pitfalls of the multi-value variant (mvQCA) in comparison with the more established crisp-set QCA (csQCA) and fuzzy-set QCA (fsQCA) variants. So far, the mvQCA methodology has been implemented either algebraically or via specific software tools such as TOSMANA. The main goal of this paper is to enhance the mvQCA methodology through the utilization of several varieties of Karnaugh maps including (a) the Conventional Karnaugh Map (CKM), (b) the Multi-Valued Karnaugh Map (MVKM), and (c) the Var
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Avar, Merve, Daniel Heinzer, Nicolas Steinke, et al. "Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line." Life Science Alliance 3, no. 8 (2020): e202000814. http://dx.doi.org/10.26508/lsa.202000814.

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Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical and biological constraints. Human cell lines might be more useful, but they are much more biohazardous and are often poorly infectible. Here, we describe the human clonal cell line hovS, which lacks the human PRNP gene and expresses instead the ovine PRNP VRQ allele. HovS cells were highly susceptible to the PG127 strain of sheep-derived murine prions, reaching up to 90% infected c
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Brainard, Julii, Charlotte C. Hammer, Maha Bouzid, and Paul R. Hunter. "Emerging pathogens and deliberate attacks on European water supplies: a scenario planning workshop." Journal of Water and Health 17, no. 3 (2019): 463–76. http://dx.doi.org/10.2166/wh.2019.248.

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Abstract Microbiological contamination of drinking water supplies is an ever-present concern for water utility managers. Most such threats are routine, well-recognised and described. Therefore, they can usually be prevented using standard protection measures. Incidents involving emerging pathogens and malicious attacks are inherently less predictable. In a multi-stage process over one day, participants with backgrounds in microbiology, medicine, infrastructure, data analysis, environmental or public health and facility management developed qualitative scenarios on potential threats posed by ei
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Krzewińska, Maja, Gro Bjørnstad, Pontus Skoglund, et al. "Mitochondrial DNA variation in the Viking age population of Norway." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1660 (2015): 20130384. http://dx.doi.org/10.1098/rstb.2013.0384.

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The medieval Norsemen or Vikings had an important biological and cultural impact on many parts of Europe through raids, colonization and trade, from about AD 793 to 1066. To help understand the genetic affinities of the ancient Norsemen, and their genetic contribution to the gene pool of other Europeans, we analysed DNA markers in Late Iron Age skeletal remains from Norway. DNA was extracted from 80 individuals, and mitochondrial DNA polymorphisms were detected by next-generation sequencing. The sequences of 45 ancient Norwegians were verified as genuine through the identification of damage pa
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Paran, Nir, Assaf Ori, Izhak Haviv, and Yosef Shaul. "A Composite Polyadenylation Signal with TATA Box Function." Molecular and Cellular Biology 20, no. 3 (2000): 834–41. http://dx.doi.org/10.1128/mcb.20.3.834-841.2000.

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ABSTRACT A variant polyadenylation signal, which is conserved and employed by mammalian hepadnaviruses, has a sequence resembling that of the TATA box. We report here that this composite box manifests all the promoter characteristics. It binds effectively TATA-binding protein with TFIIB and TFIIA in a synergistic manner. This capacity, however, is lost when the box is converted to a canonical and simple poly(A) signal. Furthermore, we show that it has promoter activity and supports transcription of reporter genes preferentially in liver-derived cells, a characteristic behavior of the hepatitis
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Vallbracht, Melina, Marina Schnell, Annemarie Seyfarth, et al. "A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus." Viruses 16, no. 1 (2023): 26. http://dx.doi.org/10.3390/v16010026.

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Herpesvirus entry requires the coordinated action of at least four viral glycoproteins. Virus-specific binding to a cellular receptor triggers a membrane fusion cascade involving the conserved gH/gL complex and gB. Although gB is the genuine herpesvirus fusogen, it requires gH/gL for fusion, but how activation occurs is still unclear. To study the underlying mechanism, we used a gL-deleted pseudorabies virus (PrV) mutant characterized by its limited capability to directly infect neighboring cells that was exploited for several independent serial passages in cell culture. Unlike previous revert
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36

Stovba, Oleksiy. "The Body as Norm: Non-Classic Ontology of Law." Philosophy of law and general theory of law, no. 1 (April 23, 2023): 51–66. http://dx.doi.org/10.21564/2707-7039.1.275626.

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The article is dedicated to the reasoning of the norm of law. Traditionally norm of law was interpreted as the rule, which is fixed in legislation and guaranteed by the state coercion. The other variant of interpretation were reasonably grounded ideal rules of natural law. In the sociological doctrine law presents itself as the custom, exists implicitly in the social relations. But all the similar approaches leave without an answer the next question: in what way the ordinary people, who belong to the different legal cultures and traditions and even not imagine themselves the legal content of n
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NØRGAARD, Per, and Jakob R. WINTHER. "Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity." Biochemical Journal 358, no. 1 (2001): 269–74. http://dx.doi.org/10.1042/bj3580269.

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Protein disulphide isomerase (PDI) is an essential protein which is localized to the endoplasmic reticulum of eukaryotic cells. It catalyses the formation and isomerization of disulphide bonds during the folding of secretory proteins. PDI is composed of domains with structural homology to thioredoxin and with CXXC catalytic motifs. EUG1 encodes a yeast protein, Eug1p, that is highly homologous to PDI. However, Eug1p contains CXXS motifs instead of CXXC. In the current model for PDI function both cysteines in this motif are required for PDI-catalysed oxidase activity. To gain more insight into
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38

Leghari, Mehwish, Asghar ali Chandio, Muhammad Ali Soomro, Shah Zaman Nizamani, and Muhammad Hanif Soomro. "A Comparative Analysis of Machine Learning Algorithms for Online Signature Recognition." VFAST Transactions on Software Engineering 12, no. 2 (2024): 231–40. http://dx.doi.org/10.21015/vtse.v12i2.1845.

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Biometrics recognition plays a vital role in modern human recognition and verification systems. An extensive latest research by the research community has rendered the field of biometrics inevitable for real-life applications. This research study focuses on online signature recognition. The research study is performed to identify if an online signature is genuine or forged. A novel online signature dataset, based on 1000 online signatures, has been collected from 200 participants, wherein every participant provided 5 instances of the online signature. An Android-based mobile application was de
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Kulakova, Anastasia I. "PRISON TOPOS AS AN ANTI-HOME IN V.G. KOROLENKO’S SHORT STORY YASHKA." IKBFU's Vestnik. Series: Humanities and Social Sciences, no. 1 (2025): 66–74. https://doi.org/10.5922/vestnikpsy-2025-1-6.

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The relevance of the problem addressed lies in the importance of studying the category of home, which actualizes essential spiritual and moral meanings, and its variant, the anti-home. Analyzing the spatial organization of V. G. Korolenko’s story Yashka reveals that the vertical and horizontal arrangement of prison cells forms the traditional oppositions of “top — bottom” and “right — left” characteristic of Slavic mythology. A corresponding character system is constructed: the protagonist, Yakov, who disturbs everyone with his loud, persistent knocking aimed at denouncing the authorities, is
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40

Paldor, Nathan, Shira Rubin, and Arthur J. Mariano. "A Consistent Theory for Linear Waves of the Shallow-Water Equations on a Rotating Plane in Midlatitudes." Journal of Physical Oceanography 37, no. 1 (2007): 115–28. http://dx.doi.org/10.1175/jpo2986.1.

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Abstract The present study provides a consistent and unified theory for the three types of linear waves of the shallow-water equations (SWE) in a zonal channel on the β plane: Kelvin, inertia–gravity (Poincaré), and planetary (Rossby). The new theory is formulated from the linearized SWE as an eigenvalue problem that is a variant of the classical Schrödinger equation. The results of the new theory show that Kelvin waves exist on the β plane with vanishing meridional velocity, as is the case on the f plane, without any change in the dispersion relation, while the meridional structure of their h
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Shramenko, Katherine, Georgiy Gorodnik, Valentina Shano, Irina Kuznetsova, Aleksandr Grigorenko, and Vladimir Potapov. "PHARMACOLOGICAL CORRECTION OF INTERCEPT HEMODYNAMICS IN ACUTE KIDNEY DAMAGE (PART 1)." Research Results in Pharmacology 3, no. (3) (2017): 110–20. https://doi.org/10.18413/2313-8971-2017-3-3-110-120.

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Introduction: Development of vasoconstriction of kidney arterioles and reduction of renal blood flow is one of the main mechanism of acute kidney injury (AKI) formation. Methods for evaluation of intrarenal hemodynamics status are rather limited. Evident interest for the clinician is the possibility of rapid and non-invasive assessment of renal hemodynamics using the dopplerography method. The method makes it possible to visualize the kidney vessels and conduct a qualitative and quantitative evaluation of renal blood flow. Peculiarities of disturbed blood flow in the kidneys can determine the
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42

Thenon, Nathan, Marisa Peyre, Mireille Huc, Abdoulaye Touré, François Roger, and Sylvain Mangiarotti. "COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact." PLOS Neglected Tropical Diseases 16, no. 9 (2022): e0010735. http://dx.doi.org/10.1371/journal.pntd.0010735.

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The epidemic of COVID-19 has shown different developments in Africa compared to the other continents. Three different approaches were used in this study to analyze this situation. In the first part, basic statistics were performed to estimate the contribution of the elderly people to the total numbers of cases and deaths in comparison to the other continents; Similarly, the health systems capacities were analysed to assess the level of underreporting. In the second part, differential equations were reconstructed from the epidemiological time series of cases and deaths (from the John Hopkins Un
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Nasipkhan Kh., Suyunova. "«Home» and «world» in the consciousness of the hero of I. Kapaev’s story «Salam, Mikhail An-dreevich!»." Kavkazologiya 2024, no. 4 (2024): 289–301. https://doi.org/10.31143/2542-212x-2024-4-289-301.

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The article analyses the experience of artistic comprehension of the relationship between “Home” and “World” in the consciousness of another one incarnation of the cross-cutting hero (Karamov) through several works of I. Kapaev. It is noted that the theme of choice of the way of interaction with the World by a hero with a “shocked consciousness”, represents leitmotiv in I. Kapaev’s prose, and the fate of each of his Karamovs appears as a variant of its realization. The hero of the analyzed story, Mukhtar Karamov, an agricultural machinery operator, en-counters the World” at his departure from
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44

Herrmann, Harald, Eva Cabet, Nicolas R. Chevalier, et al. "Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice." Circulation 142, no. 22 (2020): 2155–71. http://dx.doi.org/10.1161/circulationaha.120.050218.

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Background: Mutations in the human desmin gene cause myopathies and cardiomyopathies. This study aimed to elucidate molecular mechanisms initiated by the heterozygous R406W-desmin mutation in the development of a severe and early-onset cardiac phenotype. Methods: We report an adolescent patient who underwent cardiac transplantation as a result of restrictive cardiomyopathy caused by a heterozygous R406W-desmin mutation. Sections of the explanted heart were analyzed with antibodies specific to 406W-desmin and to intercalated disc proteins. Effects of the R406W mutation on the molecular properti
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Spasic, Ivana, and Tamara Petrovic. "Variants of „Third Serbia“." Filozofija i drustvo 23, no. 3 (2012): 23–44. http://dx.doi.org/10.2298/fid1203023s.

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This paper examines different forms in which ?Third Serbia? is being discursively constructed. This concept has recently been offered within the public arena as the alternative to the former division into ?First? and ?Second? Serbia. Although the name is the same, ?Third Serbia? is not one but many. They all share an explicit call for overcoming cleavages and extremes, which are perceived as overdrawn, artificial, and/or removed from genuine concerns and interests of Serbian society. There is also a moral claim contained in this, since what is offered is presented as better and more correct th
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Хусейн, С. Х., and Л. Б. Пархоменко. "Perspectives of Pancreatic Serous Cystadenoma Diagnostic Challenges and Management: Avoiding Irrelevant Surgery." Евразийский онкологический журнал 11, no. 4 (2023): 337–46. http://dx.doi.org/10.34883/pi.2023.11.4.017.

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Кистозные образования поджелудочной железы делят на 2 типа: воспалительные (псевдокисты) и истинные кисты, причем наиболее распространенной является воспалительная киста поджелудочной железы. Истинные кисты разделяют на 3 типа: неопластические (10–15%), застойные (10%) и врожденные (5%). Кистозные новообразования поджелудочной железы составляют 1–5% всех первичных опухолей поджелудочной железы. К ним относят серозную цистаденому. Серозная цистаденома выглядит как сферическая, заполненная жидкостью, прозрачная кистозная опухоль с четко выраженными дольчатыми краями. Чаще встречается одиночное п
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47

Avanzi, Mathieu, and Elisabeth Stark. "A crowdsourcing approach to the description of regional variation in French object clitic clusters." Current trends in analyzing syntactic variation 31 (December 31, 2017): 76–103. http://dx.doi.org/10.1075/bjl.00004.ava.

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Abstract Our contribution is dedicated to the empirical testing of alleged regional variants of object clitic clusters in modern French in France, Belgium and Switzerland. We provide some intriguing new insights into the regional distribution of non-standard variants and discuss one hypothesis on their nature and two hypotheses to explain their coming into being: language-contact (with Francoprovençal, Occitan and Oïl dialects, H1) and/or analogical leveling (H2), on the one hand, and their postsyntactic, rather than syntactic, nature, on the other (H3). Our main results reveal that the three
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48

Amusin, M. F. "Variants of metaprose." Voprosy literatury, no. 4 (September 23, 2022): 95–121. http://dx.doi.org/10.31425/0042-8795-2022-4-95-121.

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The article is concerned with the Russian prose that emerged in the years before the perestroika, in the 1970s — 1980s, and specifically, with authors who showed a clear tendency towards the techniques and structures typical of metafiction: A. Bitov, V. Makanin, A. and B. Strugatsky, and others. According to the author, it is their books that demonstrate a consistent and deliberate employment of metafictional techniques and constructs, where the metafictional nature is manifested as the use of methods that accentuate and simultaneously disrupt the boundary between fiction and real life, as wel
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Oliva, Esther Natalie, Maria Cuzzola, Anna Candoni, et al. "Novel Gene Mutations Associated with Disease-Free Survival in Elderly Patients with Acute Myeloid Leukemia Receiving First-Line Induction-Consolidation with or without Azacitidine Post-Remission Treatment." Blood 142, Supplement 1 (2023): 6046. http://dx.doi.org/10.1182/blood-2023-186325.

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Background: The achievement of complete remission (CR) is an important milestone for patients with acute myeloid leukemia (AML) undergoing curative-intent therapy. However, patients who achieve CR with induction therapy for AML will relapse within months. Therefore, research is focused on prolonging leukemia-free survival (DFS). We have recently reported on the randomized phase III study to compare the efficacy and safety of azacitidine (AZA) versus best supportive care (BSC) for treatment of AML in elderly patients who achieved first CR after a homogeneous intensive induction and consolidatio
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50

Heilmann, Margareta. "Commutativity and spectral properties of genuine Baskakov-Durrmeyer type operators and their \(k\)th order Kantorovich modification." Journal of Numerical Analysis and Approximation Theory 44, no. 2 (2015): 166–79. http://dx.doi.org/10.33993/jnaat442-1078.

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In this paper we present an overview of commutativity results and different methods for the proofs for Baskakov-Durrmeyer type operators and associated differential operators. We discuss the spectral properties and generalize all results to \(k\)th order Kantorovich modifications and corresponding Durrmeyer type variants of Bleimann, Butzer and Hahn operators and Meyer-Konig and Zeller operators.
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