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1

Bouvet, Jean-Philippe, Marie-Yvane Daire, Jean-Paul Le Bihan, Olivier Nillesse, Anne Villard-Le Tiec, Michael Batt, and Catherine Bizien-Jaglin. "La France de l'Ouest (Bretagne, Pays de la Loire)." Gallia 60, no. 1 (2003): 75–105. http://dx.doi.org/10.3406/galia.2003.3144.

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Strullu-Derrien, C., C. J. Cleal, C. Ducassou, A. R. T. Spencer, E. Stolle, and V. O. Leshyk. "A rare late Mississipian flora from Northwestern Europe (Maine-et-Loire Coalfield, Pays de la Loire, France)." Review of Palaeobotany and Palynology 285 (February 2021): 104359. http://dx.doi.org/10.1016/j.revpalbo.2020.104359.

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3

Aubrat, Marion, and Joachim Lemeri. "Advancing environmental mitigation on the Bretagne–Pays de la Loire railway, France." Proceedings of the Institution of Civil Engineers - Engineering Sustainability 171, no. 8 (December 2018): 402–10. http://dx.doi.org/10.1680/jensu.16.00014.

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Le Féon, Violette, Doriane Blottière, David Genoud, and Olivier Lambert. "Contribution à la connaissance des abeilles de la Loire-Atlantique, du Maine-et-Loire et de la Vendée." Osmia 8 (November 2020): 63–81. http://dx.doi.org/10.47446/osmia8.5.

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We present an overview of a study on bees carried out by the Centre Vétérinaire de la Faune Sauvage et des Écosystèmes (CVFSE, Nantes, France) between 2014 and 2018. Bees were collected through net sampling in 84 sites located in 43 cities of the French region Pays de la Loire (32 cities in Loire-Atlantique, 4 in Maine-et-Loire, and 7 in Vendée). Sampling occurred in different types of habitats: urban areas, agricultural areas, and semi-natural habitats like grasslands, woodlands, and coastal zones. This study provided information on the distribution of 278 bee species, among which several were previously unknown to the Armorican Massif (Andrena florivaga, Chelostoma distinctum, Coelioxys obtusa, Eucera clypeata, E. pannonica, Hylaeus clypearis, H. leptocephalus, H. punctatus, Lasioglossum tarsatum, Nomada errans, N. furva, N. lisenmaieri, N. rubiginosa, N. villosa, and Sphecodes pseudofasciatus). It highlighted the great bee species richness in semi-natural habitats, notably in the coastal dunes, but also in some urban or suburban sites, as long as the management is favourable to bees.
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Daculsi, G., Daniel Chappard, Eric Aguado, G. Legeay, Pierre Layrolle, and Pierre Weiss. "Multiphasic Biomaterials: A Concept for Bone Substitutes Developed in the "Pays de la Loire"." Key Engineering Materials 361-363 (November 2007): —17——1. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.-17.

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This paper reports on the research into multiphase bone substitutes carried out by laboratories from the ‘Pays de la Loire’ region in France. This collaborative research was funded by both the French Government and the Regional Council in the period 2000-2007. Calcium phosphate bioceramics, polymers and combinations have been developed as bone substitutes for various maxillofacial and orthopaedic applications. These bone substitutes should support and regenerate bone tissue and resorb after implantation. In the bone tissue engineering area, they have been combined with autologous bone marrow cells or bioactive factors. The bone substitutes were tested in various animal models mimicking clinical situations or under pathological conditions (osteoporosis). In order to complete our research, the multiphase materials were also evaluated in clinical trials.
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Blanquefort, P., and F. Benoit. "Eradication of Porcine Reproductive and Respiratory Syndrome virus in 125 herds in “Pays de la Loire" (France)." Veterinary Research 31, no. 1 (January 2000): 94–95. http://dx.doi.org/10.1051/vetres:2000008.

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7

Lodé, Thierry. "The decline of otter Lutra lutra populations in the region of the pays de loire, Western France." Biological Conservation 65, no. 1 (1993): 9–13. http://dx.doi.org/10.1016/0006-3207(93)90190-c.

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8

Cantat, Olivier, Olivier Planchon, Hervé Quénol, Edwige Savouret, Benjamin Bois, François Beauvais, and Sophie Brunel-Muguet. "Gelées tardives et viticulture en basse et moyenne Vallée de la Loire (France)." Climatologie 16 (2019): 91–128. http://dx.doi.org/10.4267/climatologie.1413.

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Dès que la situation météorologique est propice à l’établissement d’un temps clair et calme, des contrastes thermiques importants apparaissent de nuit au gré de facteurs locaux comme la topographie et la nature des sols. Si l’on croise ces composantes atmosphériques et géographiques avec la phénologie de la vigne, le printemps s’avère être une période particulièrement surveillée en raison de l’occurrence possible de gelées pouvant hypothéquer le développement du végétal et, par conséquent, pénaliser la production de raisins impactant les filières maraîchères et viticoles. Ce fut notamment le cas en France et dans certains pays voisins fin avril 2016, avec localement des gelées sous abri fortes (inférieures à -5°C) et durables (plusieurs heures consécutives). Le phénomène s’est également produit en 2017 et 2019. Pour illustrer les combinaisons de situations météorologiques et de phénomènes topoclimatiques à risques gélifs chez la vigne, l’étude de cas porte sur la basse et moyenne vallée de la Loire, région viticole française objet du programme européen LIFE-ADVICLIM (ADaptation of VIticulture to CLIMate change : High resolution observations of adaptation scenarii). Après avoir présenté le cadre climatique général du secteur d’étude, le contexte météorologique d’échelle synoptique et la particularité des gelées tardives par rapport à celles de pleine saison hivernale, l’article analyse la géographie à échelle fine de l’événement gélif du 27 avril 2016 entre Nantes et Orléans. Un zoom sur deux stations voisines représentatives de contextes géographiques différents (Romorantin à la topographie en creux sur sol sableux et Lye sur une colline dégagée) permet ensuite de montrer comment les jeux d’échelles spatio-temporelles mènent à une répartition thermique tout en contrastes, entre l’échelle synoptique (pour définir un potentiel de gelée tardive) et locale (pour en voir l’expression effective sur le terrain, en intensité comme en durée).
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9

Davodeau, Hervé. "La sensibilité paysagère à l’épreuve de la gestion territoriale." Cahiers de géographie du Québec 49, no. 137 (March 9, 2006): 177–89. http://dx.doi.org/10.7202/012299ar.

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Résumé En France, la Loi sur la protection et la mise en valeur des paysages adoptée en 1993 incite les collectivités locales à faire de la protection et de la valorisation des paysages un objectif de leurs politiques d’aménagement. Aux diverses échelles des territoires (la région étudiée est celle des Pays de la Loire), l’invocation du paysage prend différents sens. Mais ces nouvelles échelles du paysage d’aménagement posent des problèmes aux gestionnaires: comment les politiques publiques concilient-elles l’appréhension sensible des paysages avec les échelles territoriales de leur mise en oeuvre? La dimension territoriale de la gestion paysagère appelle une transformation du projet paysager.
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Larramendy-Magnin, S., T. Hérault, Y. Lequeux, and L. Moret. "Perception de la sécurité des soins par les médecins généralistes : une évaluation en Pays-de-la-Loire, France." Revue d'Épidémiologie et de Santé Publique 64 (September 2016): S242. http://dx.doi.org/10.1016/j.respe.2016.06.271.

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11

Hanf, Matthieu, Simon Nusinovici, Valérie Rouger, Marion Olivier, Isabelle Berlie, Cyril Flamant, Géraldine Gascoin, Patrick Van Bogaert, and Jean-Christophe Rozé. "Cohort Profile: Longitudinal study of preterm infants in the Pays de la Loire region of France (LIFT cohort)." International Journal of Epidemiology 46, no. 5 (July 3, 2017): 1396–97. http://dx.doi.org/10.1093/ije/dyx110.

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Poligot-Pitsch, Stéphanie, Pierre Marchand, Aurélie Tisserand, Alexandre Pirolley, Bernard Héry, Christian Salles, Marie-Andrée Arago, Frédéric Hernandez, Claire Rodier, and Marie George Tournoud. "Hydrométrie et continuité écologique : méthodes pour un compromis entre sensibilité et franchissabilité." La Houille Blanche, no. 5-6 (October 2018): 58–65. http://dx.doi.org/10.1051/lhb/2018052.

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Dans beaucoup de régions, le contexte physique et la sévérité des étiages que les cours d'eau connaissent ont conduit les hydromètres à utiliser de nombreux seuils comme contrôles hydrauliques afin de fiabiliser les mesures des bas débits. L'amélioration de l'état écologique des cours d'eau requiert a contrario une diminution des obstacles à la continuité écologique. La DREAL Pays de la Loire s'est donc impliquée pour rechercher des solutions de compromis et une méthodologie d'étude évitant le cas par cas pour aboutir à des principes directeurs pour l'étude et le dimensionnement des modifications des seuils. Dans le même temps, l'UMR Hydrosciences de Montpellier étudiait un remodelage d'un seuil implanté près de l'exutoire du tributaire principal de l'étang de Thau, en France, la rivière Vène. L'enjeu essentiel est d'intégrer au seuil existant, un dispositif de montaison de l'anguille européenne (Anguilla anguilla) et de conserver la sensibilité de la mesure pour les conditions de crue tout en améliorant la sensibilité en période d'étiage. Lors de cette étude, on retrouve en filigrane les principes directeurs établis par la DREAL Pays de la Loire. Ceux-ci, établis par croisement des contraintes de l'hydrométrie et de la continuité écologique, consistent à privilégier un profil de seuil à crête épaisse et présentant une encoche, la concentration de l'écoulement à faible débit étant conjointement favorable. L'article propose des exemples de dimensionnement par le calcul et par prototype modifiable in-situ.
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13

BELCHIOR, E., D. BARATAUD, R. OLLIVIER, I. CAPEK, K. LAROUCAU, B. DE BARBEYRAC, and B. HUBERT. "Psittacosis outbreak after participation in a bird fair, Western France, December 2008." Epidemiology and Infection 139, no. 10 (March 14, 2011): 1637–41. http://dx.doi.org/10.1017/s0950268811000409.

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SUMMARYIn December 2008, three hospitalized cases of suspected psittacosis infection were notified by respiratory disease clinicians from a local hospital to the Regional Epidemiology Unit of Pays de la Loire, France. They all had attended a bird fair. A retrospective cohort study was conducted among exhibitors and organizers to identify potential risk factors in relation to this fair. Environmental and veterinary investigations were implemented to trace potential sources of infection. We identified two confirmed, two probable and 44 possible cases among participants. The attack rate in exhibitors and organizers was 38% (33/86). The median incubation period was 11 days (range 6–22 days). Individuals located in two particular sectors of the showroom were found to be at double the risk of developing psittacosis (relative rate 2·1, 95% confidence interval 1·03–4·18) than those in other sectors. Pooled faecal samples of birds belonging to a possible case exhibitor tested positive for Chlamydiaceae by PCR. Ventilation conditions in the showroom were inadequate. This investigation allowed the formulation of recommendations to prevent psittacosis in bird exhibitions which are held weekly in France.
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14

Audrain, Marie, and Caroline Thomas. "Neonatal Screening for SCID: The French Experience." International Journal of Neonatal Screening 7, no. 3 (July 12, 2021): 42. http://dx.doi.org/10.3390/ijns7030042.

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After it was demonstrated in 2005 that T cell receptor excision circle (TREC) quantification for dried blood spot (DBS) samples on Guthrie cards is an effective means of SCID screening and following several pilot studies, the practice was formally recommended in the US in 2010. More and more countries have adopted it since then. In France, before the health authorities could recommend adding SCID to the list of five diseases that were routinely screened for, feasibility and cost-effectiveness studies had to be conducted with a sufficiently large cohort of neonates. We carried out three such studies: The first sought to verify the effectiveness of the assay. The second, DEPISTREC, evaluated the feasibility of universal SCID screening in France and assessed the clinical benefit and economic advantage it would provide. Through the third study, NeoSKID, still under way and to continue until recommendations are issued, we have been offering SCID screening in the Pays de la Loire region of France. This review briefly describes routine newborn screening (NBS) and management of primary immunodeficiency diseases (PIDs) in France, and then considers the lessons from our studies and the status of SCID screening implementation within the country.
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15

Audet, Josie. "Lesterlin, B. et Moreau, D. (2009). Se former en enseignant : devenir pédagogue. Nantes, France : SCÉRÉN-CRDP, Pays de la Loire." Revue des sciences de l'éducation 37, no. 1 (2011): 196. http://dx.doi.org/10.7202/1007685ar.

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16

Frère, Dominique, and Marie-Hélène Santrot. "L'anticomanie dans l'Ouest de la France : histoire des collections grecques, étrusques et phéniciennes en Bretagne et Pays de la Loire." Bulletin de la Société Nationale des Antiquaires de France 2004, no. 1 (2011): 74–75. http://dx.doi.org/10.3406/bsnaf.2011.10844.

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17

LE COZLER, Y., O. RECOURSÉ, E. GANCHE, D. GIRAUD, J. DANEL, M. BERTIN, and P. BRUNSCHWIG. "A survey on dairy heifer farm management practices in a Western-European plainland, the French Pays de la Loire region." Journal of Agricultural Science 150, no. 4 (February 16, 2012): 518–33. http://dx.doi.org/10.1017/s0021859612000032.

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SUMMARYDespite practical information and applied results from numerous experimental studies and/or field observations, there is a persistent gap between scientific recommendations and on-farm reality. There are numerous published reports on the impact of dairy heifer herd management conditions on short-term, medium-term and long-term performances, but few studies on actual dairy heifer herd management practices – particularly in France. In an attempt to address this shortfall, a survey was conducted in 2010 on 449 herds located in the second largest dairy production region, the Pays de la Loire region (Western France). Economic-related aspects of heifer farming were not addressed. The essentially qualitative survey information was collected by 107 independent agricultural technologists. A quantitative analysis based on a small set of the most representative key production criteria was also conducted on a representative sub-sample of 286 herds. Mean herd size, at 46·6 cows per farm, and milk production, at 7953 kg milk/cow/lactation, were close to French national averages (47·3 cows per farm and 8109 kg milk/cow/lactation). The survey covered nine core themes and confirmed an all-round lack of precise monitoring on animal growth, as reported in earlier studies performed outside France. Most of the farmers surveyed considered animal weight a useful indicator for estimating growth performance. However, very few actually weighed their animals, despite the fact that 0·80 of the farmers surveyed aimed to calve their heifers before 30 months of age, with 0·55 of them setting a minimum calving weight target of at least 610 kg. Mean calf age at weaning was 2·9 months, but in practice this was >3·5 months in 0·31 of cases. Although farmers differ on certain practices, common core foci emerged: weight or age targets for pre-determined growth and development stages (at weaning or at service), recycling non-marketable milk for feeding young calves, essentially visual oestrus detection methods, and others. Based on the farmers’ declarations, the estimated time spent rearing a heifer from birth to calving ranges from 12 to 15 h per animal, with most farmers spending an estimated 0–2 h/day rearing their heifers. While almost two-thirds of farmers stated that rearing heifers was a necessity, 0·36 of this survey population claimed they enjoyed the work, whereas 0·02 of the farmers felt the work was purely a chore. Mirroring the conclusions from other countries, dairy heifer herd performances could be improved through better animal monitoring and management.
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Bonnet, Manon, Gérald Guédon, Marc Pondaven, Sandro Bertolino, Damien Padiolleau, Vanessa Pénisson, Francine Gastinel, et al. "Aquatic invasive alien rodents in Western France: Where do we stand today after decades of control?" PLOS ONE 16, no. 4 (April 8, 2021): e0249904. http://dx.doi.org/10.1371/journal.pone.0249904.

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Two aquatic invasive alien rodents, the coypu (Myocastor coypus) and muskrat (Ondatra zibethicus), have taken over a significant amount of wetlands in France. Pays de la Loire is an administrative region of about 32 000 km2 in the Western France with 6.3% of its area in wetlands (excluding the Loire River). Populations of coypus and muskrats are established and a permanent control programme has been set to reduce their impacts. The control plan is based on few professional trappers and many volunteers which makes this programme unique compared to other programme relying on professionals only. The aim of this study is to analyse the temporal and spatial dynamics of coypu and muskrat captures during the last 10 years to evaluate their effectiveness. The number of rodents removed per year increased by 50% in 10 years and reached about 288 000 individuals in 2016 with about 80% of them being coypus. During the same time length, the number of trappers involved in the programme also increased by 50% to reach 3 000 people in 2016. Although the raise of coypus and muskrats trapped can possibly be explained by an increase of the number of trappers, the number of coypus removed per trapper per year increased by 22%. Despite the outstanding number of individuals removed per year, our results suggest that the programme does not limit the population dynamics of coypus. Finally, since 2017, the number of data gathered from municipalities decreased, as did the total number of individuals trapped. Indeed, although rewards are crucial to recruit new volunteers, subsidies from local and regional authorities are declining. Decision makers and financers should be encouraged to fund this programme from the perspectives of the direct or indirect costs related to the presence of aquatic invasive alien rodents in wetlands.
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Thibaut, S., P. Lombrail, J. Caillon, G. Potel, F. Ballereau, and D. Lepelletier. "Who are the carriers of MRSA in the community? A prospective study in the Pays de la Loire region of France." Clinical Microbiology and Infection 16, no. 7 (July 2010): 915–20. http://dx.doi.org/10.1111/j.1469-0691.2009.02953.x.

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BOUGHTON, ZOË. "When perception isn't reality: Accent identification and perceptual dialectology in French." Journal of French Language Studies 16, no. 3 (October 11, 2006): 277–304. http://dx.doi.org/10.1017/s0959269506002535.

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This article examines levelling and diversity in northern urban French pronunciation through the optic of folk (= non-linguists') perceptions of variation. These perceptions are investigated by the identification of authentic voice samples (rather than other instruments widely used in perceptual dialectology such as mental mapping): respondents from the Pays de la Loire region of north-western France heard extracts of scripted speech from Nancy and Rennes, and were asked to identify the speakers' regional background and say whether they were of urban or rural origin. The results of this test show that while some difference between the two speaker location groups was accurately perceived, the informants also formed some inaccurate judgements, partly based on social stereotypes. Overall there is some confirmation of accent levelling, and of general social psychological tendencies such as stereotyping, annexation and time-lag in perceptions of regional–social linguistic variation.
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Assié, Sébastien, Henri Seegers, and François Beaudeau. "Incidence of respiratory disorders during housing in non-weaned Charolais calves in cow–calf farms of Pays de la Loire (western France)." Preventive Veterinary Medicine 63, no. 3-4 (May 2004): 271–82. http://dx.doi.org/10.1016/j.prevetmed.2004.01.014.

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Comentale, Bruno. "Vulgariser la géomorphologie à partir du travail de l'argile. L'exemple de la région des Pays de la Loire (Ouest de la France)." Physio-Géo, Volume 11 (January 19, 2017): 1–20. http://dx.doi.org/10.4000/physio-geo.5140.

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Lambert-Servien, E., G. Clemenceau, O. Gabory, E. Douillard, and J. Haury. "Stoneworts (Characeae) and associated macrophyte species as indicators of water quality and human activities in the Pays-de-la-Loire region, France." Hydrobiologia 570, no. 1 (October 2006): 107–15. http://dx.doi.org/10.1007/s10750-006-0169-1.

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Rastvortseva, Svetlana, and Alexandra Korbankova. "Measuring the Creative Capital and its Development in the Regions of France." Contemporary Europe 101, no. 1 (February 28, 2021): 74–85. http://dx.doi.org/10.15211/soveurope120217485.

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Since the publication of the highly cited book of Richard Florida (“The Rise of the Creative Class. And How it's Transforming Work, Leisure and Everyday Life”), creativity has been considered as a new paradigm for economic development of cities and regions. In this context, evaluating the creative class and the creative capital has become an increasingly important concern. At the same time, measuring creative capital, in European countries in particular, remains underinvestigated. This paper is aimed at redressing this gap by evaluating the creative capital index for several regions of France. A multi-method research design was based on the Creative Capital Index project by PwC Russia. It was used to analyze both primary and secondary data on five main variables – “Regional development”, “Population”, “Business environment”, “Government” and “Brands” – from several French regions (Île-de-France, Auvergne-Rhône-Alpes, Bretagne, Occitanie and Pays de la Loire) obtained from European, national and regional open databases, official websites of governmental and non-governmental organizations and other online resources. The analysis of the results of creative capital index estimation and the investigation of creative projects, strategies and programs that were implemented in the regions under study has shown that each region has its competitive advantage in terms of specific aspects of creative capital. The results of the study may be of use to economists and policymakers by enabling them to recognize the key factors of creativity in their regions.
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Robin, Marc, Martin Juigner, Florent Luquet, and Morgane Audère. "Assessing Surface Changes between Shorelines from 1950 to 2011: The case of a 169-km Sandy Coast, Pays de la Loire (W France)." Journal of Coastal Research 88, sp1 (December 11, 2019): 122. http://dx.doi.org/10.2112/si88-010.1.

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Richet, Hervé, Michel Wiesel, Florence Le Gallou, Béatrice André-Richet, and Eric Espaze. "Methicillin-Resistant Staphylococcus aureus Control in Hospitals: The French Experience." Infection Control & Hospital Epidemiology 17, no. 8 (August 1996): 509–11. http://dx.doi.org/10.1017/s0195941700004689.

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AbstractThe first cases of isolation of Staphylococcus aureus resistant to methicillin in France were published in 1962. However, until recently, very few epidemiological studies or attempts to control the epidemic have been done in France. In this article, we present the results of a prospective study performed during a 3-month period in 27 hospitals of the Région des Pays de la Loire. Among the 94,605 hospitalized patients included in the study, 0.45% (427) developed methicillin-resistant Staphylococcus aureus (MRSA) infections, the incidence rate ranging from 0% to 1.2%. Thirty-four percent of MRSA-infected patients were 80 years old or older, 30% had been transferred from another service and 19% from another hospital, 56% were hospitalized at least once during the previous year, MRSA had been isolated at least once previously in 18% of MRSA-infected patients, 19% died, 16% were transferred to another service and 11% to another hospital, and only 32% were discharged to their homes. A poor compliance to contact isolation precautions was observed in all hospitals: 46% of MRSA-infected patients were hospitalized in a private room; gloves, masks, and gowns were worn for the care of 63.4%, 14%, and 42.5% of MRSA-infected patients, respectively; and handwashing was feasible in the rooms of 52% of the patients.
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Roquelaure, Yves, Catherine Ha, Annette Leclerc, Annie Touranchet, Camille Mariot, Ellen Imbernon, and Marcel Goldberg. "Troubles musculo-squelettiques en France : données du réseau pilote de surveillance épidémiologique dans les entreprises des Pays de la Loire en 2002 et 2003." Santé, Société et Solidarité 5, no. 2 (2006): 35–43. http://dx.doi.org/10.3406/oss.2006.1117.

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Khairallah, Diana, Olivier Chupin, Juliette Blanc, Pierre Hornych, Jean-Michel Piau, Diego Ramirez Cardona, Alain Ducreau, and Frederic Savin. "Monitoring and Modeling Railway Structures on High-Speed Lines with Asphalt Concrete Underlay: A Study on the Bretagne–Pays de la Loire Line." Transportation Research Record: Journal of the Transportation Research Board 2674, no. 12 (December 2020): 600–607. http://dx.doi.org/10.1177/0361198120960472.

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The design and durability of high-speed railway lines is a major challenge in the field of railway transportation. In France, 40 years of feedback on the field behavior of ballasted tracks led to improvements in the design rules. However, the settlement and wear of ballast, caused by dynamic stresses at high frequencies, remains a major problem on high-speed tracks leading to high maintenance costs. Studies have shown that this settlement is linked to the high acceleration produced in the ballast layer by high-speed trains traveling on the track, disrupting the granular assembly. The “Bretagne–Pays de la Loire” high-speed line (BPL HSL), with its varied subgrade conditions, represents the first large-scale application of asphalt concrete (GB) as the ballast sublayer. This line includes 77 km of conventional track with a granular sublayer of unbound granular material (UGM) and 105 km of track with an asphalt concrete sublayer under the ballast. During construction, instruments such as accelerometers, anchored deflection sensors, and strain gages, among others, were installed on four sections of the track. This paper examines the instrumentation as well as the acquisition system installed on the track. The data processing is explained first, followed by a presentation of the ViscoRail software, developed for modeling railway tracks. The bituminous section’s behavior and response is modeled using a multilayer dynamic response model, implemented in the ViscoRail software. A good match between experimental and calculated results is highlighted.
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BROQUET, T., M. THIBAULT, and A. NEVEU. "DISTRIBUTION AND HABITAT REQUIREMENTS OF THE WHITE-CLAWED CRAYFISH, AUSTROPOTAMOBIUS PALLIPES, IN A STREAM FROM THE PAYS DE LOIRE REGION, FRANCE: AN EXPERIMENTAL AND DESCRIPTIVE STUDY." Bulletin Français de la Pêche et de la Pisciculture, no. 367 (2002): 717–28. http://dx.doi.org/10.1051/kmae:2002061.

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CLEMENT, F., and E. BASSECOULARD. "La recherche équine en France et dans le monde au travers d’une analyse bibliométrique." INRAE Productions Animales 17, no. 1 (March 20, 2004): 69–76. http://dx.doi.org/10.20870/productions-animales.2004.17.1.3554.

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Pour obtenir un panorama actuel de la recherche équine en France et dans le monde, une étude bibliométrique a été réalisée à partir des publications scientifiques concernant le cheval et recensées dans les bases CAB abstracts de CAB International et Current Contents de l’Institute for Scientific Information au cours des années 1998-2000. Après une structuration thématique combinant méthodes bibliométriques et avis d’experts, ces articles ont été ventilés en fonction des thématiques étudiées, des localisations des équipes signataires et du support de communication. Le fichier final comporte 6775 publications, pour deux tiers issues de journaux scientifiques, 31 % provenant de journaux de transfert et 6 % de comptes rendus de congrès. Plus de la moitié des contributions traitent de pathologie. Viennent ensuite la locomotion et médecine sportive (17 %), la reproduction (11 %). La nutrition et la génétique se partagent 9 % des contributions. Les autres thématiques définies en sciences du vivant sont le comportement et bien-être, les espèces asines et les équidés sauvages, le dopage. Environ 4 % des notices relèvent des sciences humaines et sociales. L’Amérique du Nord et l’Union Européenne constituent les deux principaux pôles de recherche mondiaux avec 40 et 36 % des articles chacun. La France occupe la 7ème place (3,4 % des articles scientifiques) derrière les USA, le Royaume-Uni (12,5 %), l’Allemagne (6,3 %), le Japon (4,3 %), le Canada (3,8 %) et l’Australie (3,8 %). La France remonte à la 4ème place si l’on si l’on considère l’ensemble des articles. Ceci illustre l’importance de la littérature de transfert ou de comptes rendus de colloques. La France apparaît relativement spécialisée sur la reproduction, le dopage et les sciences humaines et sociales, avec en revanche un investissement relatif moindre sur le comportement et la pathologie. La région Ile de France est la première région française en matière de recherche équine, avec 37,5 % des articles. Les autres régions importantes sont les régions Centre, Rhône-Alpes, Pays de la Loire, Midi-Pyrénées et Basse-Normandie. Cette atomisation géographique des équipes explique qu’aucune ville française ne figure parmi les 25 villes leaders.
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Juigner, Martin, Marc Robin, Françoise Debaine, and Florian Hélen. "A generic index to assess the building exposure to shoreline retreat using box segmentation: Case study of the Pays de la Loire sandy coast (west of France)." Ocean & Coastal Management 148 (November 2017): 40–52. http://dx.doi.org/10.1016/j.ocecoaman.2017.07.014.

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Kerguillec, Riwan, Morgane Audère, Agnès Baltzer, Françoise Debaine, Paul Fattal, Martin Juigner, Patrick Launeau, et al. "Monitoring and management of coastal hazards: Creation of a regional observatory of coastal erosion and storm surges in the pays de la Loire region (Atlantic coast, France)." Ocean & Coastal Management 181 (November 2019): 104904. http://dx.doi.org/10.1016/j.ocecoaman.2019.104904.

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33

Feunteun, E., C. Rigaud, P. Elie, and J. C. Lefeuvre. "Le marais doux endigué de Bourgneuf-Machecoul (Pays de Loire) Premier éléments de connaissance du peuplement piscicole. Relation ichtyofaune-habitat et problèmes majeurs de gestion (Maroc)." Revue des sciences de l'eau 5, no. 4 (April 12, 2005): 509–28. http://dx.doi.org/10.7202/705144ar.

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Le peuplement ichtyologique d'un marais littoral endigué, géré en eau douce, a été étudié sur une zone de 2 700 ha, située au nord du marais Breton-Vendéen (Loire-Atlantique, France). Le réseau hydraulique, qui représente près de 16 % de cette surface, se compose, d'environ 91 m de linéaire de fossés par ha (en tout 234 km) et de bassins présents uniquement dans la partie d'origine salicole du marais. Les hauteurs d'eau, l'envasement et le recouvrement par la végétation aquatique dépendent de la gestion humaine et sont très variables (moyennes respectives : 42 cm; 43 cm; 70 %). Cela se traduit par un morcellement spatial de l'habitat pour les poissons. La stratégie d'échantillonnage adoptée, qui tient compte de cette hétérogénéité, a permis de décrire un peuplement comportant 21 espèces. Dominé par les poissons-chats et par les anguilles, ce dernier est caractéristique de la zone à brèmes des cours d'eau. Les abondances sont relativement élevées (en moyenne 315 kg/ha et 11 460 poissons/ha), mais elles sont très hétérogènes. L'évolution qualitative et quantitative de la répartition spatio-temporelle est décrite à l'aide d'une analyse factorielle des correspondances portant sur 74 échantillons prélevés par pêche électrique entre 1987 et 1989. Bien que l'approche de ce milieu soit complexe et les références bibliographiques relativement rares, l'analyse des premières données permet d'ores et déjà d'identifier quelques problèmes de gestion ayant des répercussions directes sur le peuplement piscicole de cette zone.
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Husson, C., C. Delatour, P. Frey, B. Marçais, C. Saurat, and N. Schenck. "First Report of Phytophthora ramorum on Ornamental Plants in France." Plant Disease 91, no. 10 (October 2007): 1359. http://dx.doi.org/10.1094/pdis-91-10-1359b.

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In April 2002, Phytophthora ramorum was associated with twig blight and brown spots on Rhododendron spp. leaves from a nursery in France. The isolate was identified by its morphological characters on V8 agar: slow growth, deciduous and semipapillate sporangia, and abundant production of large chlamydospores (3). The identification was confirmed by ITS rDNA sequencing. During 2002, P. ramorum was also isolated from diseased Viburnum tinus and V. × bodnantense plants exhibiting symptoms of wilting and stem base discoloration. Subsequently, repeated surveys for P. ramorum were carried out in nurseries and areas surrounding nurseries throughout France. Since 2004, a large range of known hosts were investigated in approximately 2,000 nurseries and 200 other sites each year. P. ramorum was detected exclusively in nurseries at 29 locations in 2002, 9 in 2003, 23 in 2004, 17 in 2005, and 19 in 2006. Rhododendron spp. and occasionally V. tinus were the major hosts. In addition, the pathogen was detected for the first time on Pieris japonica in two nurseries in 2005 and on Camellia sp. in one nursery in 2006 from plants exhibiting leaf and twig blight. In both cases, P. ramorum had already been detected on Rhododendron spp. in the same nurseries. Most of the infected plants were found in northwestern France (Bretagne and Pays-de-la-Loire), or came from this region, which is the main rhododendron-growing area in France. In some cases, plants were imported from Belgium or the Netherlands. P. ramorum was also detected in a nursery in soil close to diseased Rhododendron spp. plants and pond water used for irrigation by using a combination of baiting with Rhododendron spp. leaves and PCR assay with species-specific primers (1). Overall, approximately 1% of the investigated nurseries were found positive each year, and this ratio was quite stable from 2004 to 2006. To date, P. ramorum has not been detected outside of nurseries, although many surveys were conducted on the west coast of France where the risk is considered to be high because of a favorable mild and humid climate and the presence of suitable hosts. In addition, 78 isolates of P. ramorum collected between 2002 and 2004 on Rhododendron spp. and V. tinus were found to be of A1 mating type based on pairings with P. cryptogea A1 and A2 mating types (2). References: (1) K. J. Hayden et al. Phytopathology 94:1075, 2004. (2) S. Werres and B. Zielke J. Plant Dis. Prot. 110:129, 2003. (3) S. Werres et al. Mycol. Res. 105:1155, 2001.
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Melchior, M., Y. Roquelaure, B. Evanoff, J.-F. Chastang, C. Ha, E. Imbernon, M. Goldberg, and A. Leclerc. "Why are manual workers at high risk of upper limb disorders? The role of physical work factors in a random sample of workers in France (the Pays de la Loire study)." Occupational and Environmental Medicine 63, no. 11 (November 1, 2006): 754–61. http://dx.doi.org/10.1136/oem.2005.025122.

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Nordez, Marilou. "Parures annulaires massives à décor incisé du Bronze moyen au Nord-Ouest de la France (Bretagne, Pays de la Loire, Basse-Normandie). Pour une remise en question du type de Bignan." Bulletin de la Société préhistorique française 112, no. 1 (2015): 75–116. http://dx.doi.org/10.3406/bspf.2015.14491.

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Limosin, F., and J. P. Schuster. "Usage et mésusage des benzodiazépines chez le sujet âgé." European Psychiatry 30, S2 (November 2015): S44. http://dx.doi.org/10.1016/j.eurpsy.2015.09.123.

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En France, de nombreuses études indiquent un niveau élevé de prescription des psychotropes, en particulier des benzodiazépines. Ainsi, 9 % à 25 % de la population générale âgée en consomment, avec des prescriptions trop souvent au long cours et fréquemment à l’origine d’un mésusage. Chez le sujet âgé, les effets indésirables des benzodiazépines sont essentiellement psychomoteurs et cognitifs, avec augmentation du risque de chutes et de fractures, et altération de la mémoire à court terme et de rappel. Des études récentes apportent un éclairage nouveau sur le risque de dépendance aux benzodiazépines chez le sujet âgé et sur le lien entre leur prescription au long cours et la survenue d’un trouble neurodégénératif [1, 2]. Une étude réalisée avec les officines de la région Pays de la Loire indique que parmi les consommateurs réguliers de benzodiazépines, les sujets âgés présentent une dépendance moins souvent que les sujets jeunes[1]. Concernant le risque de trouble démentiel induit par un usage de benzodiazépine au long cours, une étude cas-témoin publiée l’année dernière conforte l’hypothèse d’un lien de causalité entre consommation de benzodiazépines et risque accru de maladie d’Alzheimer [2]. Face à un tel contexte, les autorités de santé se sont engagées dans un plan d’action concerté visant à « une consommation raisonnée et à une utilisation responsable des benzodiazépines ». Pourtant, à ce jour, les données de la littérature sur les interventions de sevrage des benzodiazépines chez le sujet âgé sont encore parcellaires, notamment sur leur efficacité au long cours. Des études récentes indiquent néanmoins l’importance de l’approche psychothérapique dans les programmes de sevrage dédiés au sujet âgé [3].
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Saurat, C., C. Fourrier, V. Wilson, C. Casset, and R. Ioos. "First Report of Begonia Elatior Wilt Disease Caused by Fusarium foetens in France." Plant Disease 97, no. 1 (January 2013): 144. http://dx.doi.org/10.1094/pdis-07-12-0659-pdn.

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Fusarium foetens is a destructive vascular pathogen on Begonia, mainly on cultivars of Begonia elatior hybrids (Begonia × hiemalis), which has recently been identified in Europe and Northern America (1,3). This Fusarium species has been responsible for severe damage in the begonia flower industry (1) and is listed as an EPPO A2 quarantine pathogen since 2007. In May 2007, wilted potted plants of B. elatior showing chlorotic leaves and basal stem rot were observed in a nursery located in the west of France (La Flèche, Sarthe). Symptomatic foliar and basal stem pieces were plated on a Fusarium semi selective medium, dichloran chloramphenicol peptone agar (DCPA), and on malt agar medium supplemented with 100 ppm chloramphenicol. Homogeneous mycelium of a Fusarium species developed from both types of tissue and on both media, and was transferred to potato dextrose agar (PDA) and to spezieller nährstoffarmer agar (SNA) media for morphological examination. Microscope slides were then prepared by pressing gently a clear self-adhesive tape onto the surface covered by mycelium and sporodochia, which was further stained with lactic acid/methylene blue. Typical multiseptate (often three septa), hyaline, slightly curved Fusarium macroconidia 29.2 to 41.8 (32.5) × 3.6 to 4.5 (4.3) μm were collected in sporodochia. In the aerial mycelium, long and short conidiophores with mono- or polyphialidic cells bearing false heads of ellipsoidal microconidia were observed. In addition, a pungent distinctive odor was produced by the mycelium grown on PDA. These features were consistent with F. foetens (2). To support the diagnosis, total DNA was further extracted from the pure culture and a partial region of the translation elongation 1 (tef1) gene was amplified by PCR using EF1-EF2 primer pair (4). Nucleotide sequence was determined and deposited on GenBank (Accession No. JX298790). Analysis of the sequence by BLAST showed that it was 100% identical with all the available F. foetens sequences, which confirmed our morphological diagnosis. To our knowledge, this is the first official report of F. foetens in France. Since this first detection, F. foetens was again identified in 2010 in another nursery located in the Pays de la Loire on collapsed B. elatior. Approximately 15 to 20% of the Begonia plants showed typical Fusarium wilt symptoms and the infected lots were systematically destroyed. The origin of these infections could not be traced back since the mother plants tested negative. The disease is considered as eradicated in France but causes major economic losses to Begonia growers and marketers in regions where the disease is established (2). References: (1) H. Huvenne et al. Eur. J. Plant Pathol. 131:705, 2011. (2) H. J. Schroers et al. Mycologia 96:393, 2004. (3) X. L. Tian et al. Plant Dis. 94:1261, 2010. (4) D. Geiser. Eur. J. Plant Pathol. 110:473, 2004.
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SEUX, R. "Étude expérimentale des facteurs de contamination par le CVM de l’eau des réseaux d’adduction publique." Techniques Sciences Méthodes, no. 12 (January 20, 2021): 105–26. http://dx.doi.org/10.36904/tsm/202012105.

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Depuis fin 2012, en application de l’instruction DGS/EA4/2012/366 du 18 octobre 2012, les premières campagnes de prélèvements, spécifiquement réalisées pour définir les antennes en polychlorure de vinyle (PVC) « à risques chlorure de vinyle monomère (CVM) » des réseaux ruraux des départements du nord-ouest de la France donnent bien souvent des résultats peu cohérents et difficiles à interpréter. Devant les difficultés pour identifier l’origine d’écarts considérables dans les résultats, souvent non reproductibles, obtenus lors de ces campagnes, la section territoriale Ouest – Bretagne, Pays de la Loire de l’Astee a réalisé une étude expérimentale sur deux antennes identifiées pour leur capacité à contaminer l’eau transportée par le CVM, dans des conditions hydrauliques connues et maîtrisées. Cette expérimentation a eu pour objectif de déterminer l’influence du temps de contact et de la température de l’eau sur la diffusion du CVM dans l’eau distribuée par une canalisation en PVC dans deux unités de distribution spécifiques. Les résultats, cohérents entre les deux sites expérimentaux, nous ont permis d’établir une relation entre la teneur en CVM dans l’eau, le temps de contact (tc), la température (θ), la concentration résiduelle (Cm) en CVM dans le matériau de la canalisation et son diamètre intérieur (d). La concentration en CVM dans l’eau est sensiblement proportionnelle au temps de contact pour une température donnée et elle double en passant de 10 à 19 °C. Ce modèle peut également être utilisé pour faire une estimation de l’exportation annuelle en CVM dans l’eau. Après 40 ans de service, elle reste inférieure au millième de la quantité résiduelle emprisonnée dans la masse du matériau de la canalisation.
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Gérardin, M., M. Guerlais, M. Guillou-Landréat, M. Grall-Bronnec, P. Jolliet, and C. Victorri-Vigneau. "Consommation de benzodiazépines chez le sujet âgé : quelles particularités ?" European Psychiatry 30, S2 (November 2015): S44. http://dx.doi.org/10.1016/j.eurpsy.2015.09.124.

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En décembre 2013, l’ANSM publiait un nouveau rapport sur l’état des lieux de la consommation des benzodiazépines et apparentés (BZD) en France[1]. D’après ce rapport, l’âge médian des consommateurs est de 56 ans et la consommation des BZD augmente avec l’âge. Cinquante-cinq pour cent des consommateurs les utilisent plus de 3 mois consécutifs et le temps d’exposition est plus élevé chez les sujets de plus de 65 ans. Afin de déterminer quelles sont les caractéristiques de la consommation des BZD chez les sujets âgés, nous avons réalisé une étude comparant deux groupes de consommateurs chroniques de BZD en Pays de la Loire : des sujets âgés de 65 ans ou plus (seniors) et des adultes de moins de 65 ans (adultes) [2,3]. Les sujets inclus consommaient au moins un traitement par BZD depuis 3 mois ou plus. Le questionnaire utilisé contenait des données socio-démographiques et médicales et une évaluation des modalités de consommation basée sur les items du DSM-IV et le comportement du patient (mode d’obtention, effet recherché…). Chez les seniors, la dose ou durée supérieure, les problèmes relationnels et les problèmes de santé sont moins fréquents que chez les adultes ; 35,2 % des seniors présentent 3 items du DSM-IV ou plus, versus 49,75 % des adultes. La consommation se caractérise chez les seniors par une tolérance plus fréquente, chez les adultes par des conséquences sociales et somatiques et une dose/durée supérieure à ce qui était prévu. Notre étude montre que les consommateurs chroniques de BZD n’ont pas le même profil en fonction de l’âge. Tandis que les adultes rapportent plus de pathologies psychiatriques, avec une consommation plus importante que prévue et qui entraîne des conséquences négatives au niveau social et somatique, les seniors décrivent une consommation plus ritualisée avec peu de conséquences négatives ressenties.
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Metges, J., E. Gamelin, R. Faroux, V. Klein, G. Ganem, J. Douillard, C. Stampfli, S. Corbinais, C. Riche, and F. Grude. "AVASTERB OUEST: A prospective cohort study of unresectable metastatic colon cancer treated successively by FOLFIRI bevacizumab and cetuximab irinotecan." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e15103-e15103. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15103.

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e15103 Background: Bevacizumab and cetuximab regimen are approuved since 2005 in Europe for Metastatic Colorectal Cancer Patients (MCCP). Very few studies have reported data concerning the sequence (FOLFIRI BEVA and after failure CETUXIMAB- CAMPTO) in MCCP from the real world. Methods: Since 2003, in west of France, (Bretagne-Pays de Loire),a network called OMIT(Observatoire des Médicaments et Innovations Thérapeutiques) directed by Regional Health Agencies has been created. This structure gathered prospectively data from MCCP treated with targeted therapies. Since 2006, a cohort of MCCP treated successively by FOLFIRI BEVACIZUMAB (same protocol : same dose) as first line to progression or unacceptable toxicity and CETUXIMAB- CAMPTO after the first line failure was constitued (AVASTERB cohort). Criteria for initial unresectability of metastic lesions was based on investigator's evaluations during local comitee (surgeons and oncologists). In order to have a large follow up, the 35 first patients of the cohort were studied in this abstract.Age, sex, response rate to the different regimens,secondary metastatic lesion resection, time to progression to the different regimens, follow up and overall survival are the criterias studied. Results: Median age 60 years (49–83), Males : 60%, colon 71%,rectum: 17%, colorectal jonction :12%.Response rate(OR+SD)with Folfiri Bevacizumab : 45.7%. 17% of the patients underwent hepatic surgery with curative intent (all during Folfiri bevacizumab) Time to progression with Bevacizumab : 6 months. Fifty eight percent of the patients are still alive with a median follow up of 25 months (11–29)Median overall survival was not reached.The 12 months and 24 months overall survival rates are respectively 71.4% and 45.7% (date of point: 01/01/2009). Actualisation of the data will be provided during the meeting Conclusions: The results from this prospective unselected cohort of MCCP treated with the sequence FOLFIRI BEVA and after failure CETUX-CAMPTO from the real world show promising TTP, and overall survival. The study of the Kras mutation and others biomarkers could improve these results by personalization of the treatment. This part of our study is actually ongoing. No significant financial relationships to disclose.
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Grude, Francoise, Muriel Travers, Brice Moiteaux, Nathalie Beneton, Caroline Jacobzone, Yannick Le Corre, Delphine Legoupil, et al. "Nivolumab and Pembrolizumab in advanced cutaneous melanoma : Results from real-life data in patients from France— Evaluation of use, current practices and medico economic approach." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e21009-e21009. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21009.

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e21009 Background: In 2016, Nivolumab (N) and Pembrolizumab (P) have been registred for first line ECOG PS 0-1 adult patients with non-resecable or metastatic melanoma. The Brittany and Pays de la Loire Cancer Observatory has collected data on their real-life indications, current management, safety, efficacy and medico-economics Methods: All non opposing adult patients (pts) with advanced cutaneous melanoma who initiated a treatment with N (3 mg/kg q2w) or P (2 mg/kg q3w) in 2016 and 2017 were included. Minimum follow-up for survival was 12 months. Sex, age, mutation profile, lines of treatment, toxicities, response rate, survival and treatment cost have been collected. Results: 149 pts were treated by N and 201 pts by P with a median age of respectively 68 [21-88] and 69 years [28-96]. Of the 350 patients, 34% were at least 75 years and around 30% presented a BRAF mutation. The median duration of treatment was 4.9 months [0-34.6] for N and 4.2 [0-35.8] for P (Not Significant NS). 65% of pts were treated in 1st line for N and 69% for P. 24% of the pts were treated in 2nd line for both treatments. 81% of the pts had a baseline PS of 0 or 1. All lines combined (first line for wt BRAF and first or second line for m BRAF melanoma), clinical benefit was 53% for N and 47% for P. Median OS was respectively 21.7 m for N and 22.8 m for P (NS). mPFS were respectively 6.4 m and 4.6 m (NS). 18% of pts presented grade III/IV toxicities with N and 17% with P. wt BRAF pts showed more grade III/IV toxicities than m BRAF pts (p = 0.046). For N, pts with grade III/IV toxicities showed better PFS (p = 0.051) and OS (p = 0.064). For both cohorts, PS ≥2, BRAF status and treatment line identified subgroup of pts with worsened PFS and OS 55% (24/44) of pts who stopped N or P because of death had a baseline PS of 0-1 showing PS alone is not sufficient to predict survival. Aggressive diseases (high metastasis rate, cerebro-meningeal metastasis, high tumor growth rate with any previous treatment) appear to be the worse candidates for immunotherapy. N and P courses during the 2 years costed 6.6 and 9.7 millions of euros respectively with approximatively 84% or 79% of this cost for N and P clinically benefitting pts. Conclusions: Immunotherapy in real-life setting in cutaneous advanced melanomas confirms literature’s data regarding clinical benefit, survival rate and safety profile and suggests to think about a composite predictive biomarker including BRAF status, ECOG PS, toxicity and treatment line.
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Frati, Giovanni, Patrick Launeau, Marc Robin, Manuel Giraud, Martin Juigner, Françoise Debaine, and Cyril Michon. "Coastal Sand Dunes Monitoring by Low Vegetation Cover Classification and Digital Elevation Model Improvement Using Synchronized Hyperspectral and Full-Waveform LiDAR Remote Sensing." Remote Sensing 13, no. 1 (December 23, 2020): 29. http://dx.doi.org/10.3390/rs13010029.

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Due to the coastal morphodynamic being impacted by climate change there is a need for systematic and large-scale monitoring. The monitoring of sandy dunes in Pays-de-la-Loire (France) requires a simultaneous mapping of (i) its morphology, allowing to assess the sedimentary stocks and (ii) its low vegetation cover, which constitutes a significant proxy of the dune dynamics. The synchronization of hyperspectral imaging (HSI) with full-waveform (FWF) LiDAR is possible with an airborne platform. For a more intimate combination, we aligned the 1064 nm laser beam of a bi-spectral Titan FWF LiDAR with 401 bands and the 15 cm range resolution on the Hyspex VNIR camera with 160 bands and a 4.2 nm spectral resolution, making both types of data follow the same emergence angle. A ray tracing procedure permits to associate the data while keeping the acquisition angles. Stacking multiple shifted FWFs, which are linked to the same pixel, enables reaching a 5 cm range resolution grid. The objectives are (i) to improve the accuracy of the digital terrain models (DTM) obtained from an FWF analysis by calibrating it on dGPS field measurements and correcting it from local deviations induced by vegetation and (ii) in combination with airborne reflectances obtained with PARGE and ATCOR-4 corrections, to implement a supervised hierarchic classification of the main foredune vegetation proxies independently of the acquisition year and the physiological state. The normalization of the FWF LiDAR range to a dry sand reference waveform and the centering on their top canopy echoes allows to isolate Ammophilia arenaria from other vegetation types using two FWF indices, without confusion with slope effects. Fourteen HSI reflectance indices and 19 HSI Spectral Angle Mapping (SAM) indices based on 2017 spectral field measurements performed with the same Hyspex VNIR camera were stacked with both FWF indices into a single co-image for each acquisition year. A simple straightforward hierarchical classification of all 35 pre-classified co-image bands was successfully applied along 20 km, out of the 250 km of coastline acquired from 2017 to 2019, prefiguring its systematic application to the whole 250 km every year.
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Viatte, Camille, Tianze Wang, Martin Van Damme, Enrico Dammers, Frederik Meleux, Lieven Clarisse, Mark W. Shephard, et al. "Atmospheric ammonia variability and link with particulate matter formation: a case study over the Paris area." Atmospheric Chemistry and Physics 20, no. 1 (January 17, 2020): 577–96. http://dx.doi.org/10.5194/acp-20-577-2020.

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Abstract. The Paris megacity experiences frequent particulate matter (i.e.PM2.5, particulate matter with a diameter less than 2.5 µm) pollution episodes in spring (March–April). At this time of the year, large numbers of the particles consist of ammonium sulfate and nitrate which are formed from ammonia (NH3) released during fertilizer spreading practices and transported from the surrounding areas to Paris. There is still limited knowledge of the emission sources around Paris, their magnitude, and their seasonality. Using space-borne NH3 observation records of 10 years (2008–2017) and 5 years (2013–2017) provided by the Infrared Atmospheric Sounding Interferometer (IASI) and the Cross-Track Infrared Sounder (CrIS) instrument, regional patterns of NH3 variabilities (seasonal and interannual) are derived. Observations reveal identical high seasonal variability with three major NH3 hotspots found from March to August. The high interannual variability is discussed with respect to atmospheric total precipitation and temperature. A detailed analysis of the seasonal cycle is performed using both IASI and CrIS instrument data, together with outputs from the CHIMERE atmospheric model. For 2014 and 2015, the CHIMERE model shows coefficients of determination of 0.58 and 0.18 when compared to IASI and CrIS, respectively. With respect to spatial variability, the CHIMERE monthly NH3 concentrations in spring show a slight underrepresentation over Belgium and the United Kingdom and an overrepresentation in agricultural areas in the French Brittany–Pays de la Loire and Plateau du Jura region, as well as in northern Switzerland. In addition, PM2.5 concentrations derived from the CHIMERE model have been evaluated against surface measurements from the Airparif network over Paris, with which agreement was found (r2 = 0.56) with however an underestimation during spring pollution events. Using HYSPLIT cluster analysis of back trajectories, we show that NH3 total columns measured in spring over Paris are enhanced when air masses originate from the north-east (e.g. the Netherlands and Belgium), highlighting the importance of long-range transport in the NH3 budget over Paris. Variability in NH3 in the north-east region is likely to impact NH3 concentrations in the Parisian region since the cross-correlation function is above 0.3 (at lag = 0 and 1 d). Finally, we quantify the key meteorological parameters driving the specific conditions important for the formation of PM2.5 from NH3 in the Île-de-France region in spring. Data-driven results based on surface PM2.5 measurements from the Airparif network and IASI NH3 measurements show that a combination of the factors such as a low boundary layer of ∼500 m, a relatively low temperature of 5 ∘C, a high relative humidity of 70 %, and wind from the north-east contributes to a positive PM2.5 and NH3 correlation.
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45

Chaslerie, A. C., B. F. Fuchs, F. R. Grude, H. B. Bourgeois, C. V. Vigneau Victorri, and N. G. Garrec. "G-CSF spending: Cost Impact of an intervention conducted in a French area: Pays-de-la-Loire." European Journal of Public Health 29, Supplement_4 (November 1, 2019). http://dx.doi.org/10.1093/eurpub/ckz185.078.

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Abstract Issue Granulocyte colony-stimulating factors (G-CSF), recommended by international oncology guidelines as a prophylaxis of febrile neutropenia are expensive drugs. Despite biosimilars marketing since 2008, G-CSF spending represents a major and growing expense for health insurance. Description of the problem Between 2010 and 2013 an unsustainable increase of G-CSF spending by 20% occurred in a French area: Pays-la-Loire. An intervention based on guidelines was carried out to the oncologists involved in ambulatory cancer care to reduce G-CSF spending by improving prescription and promoting biosimilars. Hospital oncologists have been the main target. A partnership between physicians and pharmacists of the Brittany - Pays-de-la-Loire Cancer Dedicated Observatory network and the Pays de la Loire Medical Department of Health insurance composed the operational team involved in the work. Interrupted time series analysis based on the French national health data system database were chosen to assess the impact of the intervention on G-CSF spending, their prescription and biosimilars use. Results Twelve professional meetings were performed to cancer medical teams from 7 community hospitals and 5 private hospitals of the Pays-de-la-Loire region. This intervention reduced G-CSF spending by 11% and improves G-CSF local use. Lessons This type of multi-stakeholder intervention carrying common to various health actor’s messages represents a promising tool to improve the quality of care and the control of health expenditure. These results and the possible cost saving showed have encouraged the heads of French health insurance to promote this action in 2019 in the whole France. Key messages In the current context of unsustainable increases in cancer cares related costs in France the rational use of G-CSF’s seemed to be one available resources. biosimilar promotion for ensure broad access to innovative cancer therapeutic for patients and finance cancer prevention campaigns.
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46

Juigner, Martin, and Marc Robin . "Caractérisation de la morphologie des massifs dunaires de la région Pays de la Loire (France) face au risque de submersion marine." VertigO, Volume 18 numéro 2 (September 5, 2018). http://dx.doi.org/10.4000/vertigo.20558.

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47

Chevillot-Miot, Elie, and Denis Mercier. "La vulnérabilité face au risque de submersion marine : exposition et sensibilité des communes littorales de la région Pays de la Loire (France)." VertigO, Volume 14 Numéro 2 (September 12, 2014). http://dx.doi.org/10.4000/vertigo.15110.

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48

Ben Ghezala, Inès, Anne Sophie Mariet, Eric Benzenine, Pierre-Henry Gabrielle, Florian Baudin, Alain M. Bron, Catherine Quantin, and Catherine P. Creuzot-Garcher. "Incidence of rhegmatogenous retinal detachment in France from 2010 to 2016: seasonal and geographical variations." British Journal of Ophthalmology, March 3, 2021, bjophthalmol—2020–318457. http://dx.doi.org/10.1136/bjophthalmol-2020-318457.

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AimsTo investigate the annual and monthly hospital incidence rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 2016 in France at the national and regional levels.MethodsIn this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France during 2010–2016 from the national administrative database. The annual and monthly hospital incidence rates of RRD per 100 000 population were calculated for the whole country and for each region.ResultsThe average annual national hospital incidence rate of RRD was 21.97±1.04 per 100 000 population. The annual national hospital incidence rate of RRD was the lowest in 2010 (20.91 per 100 000 population) after which it increased until 2015 (23.55 per 100 000 population). The average monthly national RRD hospital incidence rate was the highest in June (2.03±0.12 per 100 000 population) and the lowest in August (1.60±0.09). The average annual age-standardised and sex-standardised regional hospital incidence rate was the highest in Guadeloupe and Pays de la Loire (28.30±2.74 and 26.13±0.84 per 100 000 population, respectively) and the lowest in French Guiana and Martinique (15.51±3.50 and 17.29±2.12 per 100 000 population, respectively).ConclusionsThe average annual national hospital incidence rate of RRD increased from 2010 to 2015. The hospital incidence rate of RRD seemed to vary according to season and geographical location.
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49

Barry, Y., C. Deneux-Tharaux, M. Saucedo, V. Goulet, I. Guseva-Canu, A. A. Chantry, and N. Regnault. "Maternal admissions to Intensive Care Units in France: trends in rates, causes and severity." European Journal of Public Health 29, Supplement_4 (November 1, 2019). http://dx.doi.org/10.1093/eurpub/ckz186.185.

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Abstract Introduction Maternal intensive care unit admission (ICU) is an indicator of severe maternal morbidity. This study aimed to estimate rates of maternal ICU admission during or following pregnancy in France, and to describe the characteristics of women admitted, the severity of their condition, associated diagnoses, regional disparities, and temporal trends between 2010 and 2014. Methods Women hospitalised in France in ICU during pregnancy or up to 42 days after pregnancy between 2010 and 2014 were identified using the national hospital discharge database (PMSI-MCO). The Simplified Acute Physiology Score (SAPS II) was used to estimate the severity. Trends in incidence rates were quantified using percentages of average annual variation based on a Poisson regression model. Results In total, 16,011 women were admitted to ICU, representing an overall rate of 3.97 ‰ deliveries. The average annual decrease in this rate between 2010 and 2014 was 1.7% (IC95%:-2, 00%; -1, 45%; p < 0.0001) on average per year. The SAPS II score increased significantly from 18.4 in 2010 to 21.5 in 2014. Obstetrical hemorrhage (39.8%) and hypertensive complications during pregnancy (24.8%) were the most common reasons for admission. Within mainland France, we found notable disparities in maternal ICU admission rates between regions, from lowest in Pays-de-la-Loire region (2.69‰) to highest in Ile-de-France (5.05‰). Conclusions The rate of maternal ICU admission decreased from 2010 to 2014 in France, with a concomitant increase in case severity. Additional studies are needed to understand the territorial disparities identified in our study. Key messages The decreasing incidence of maternal ICU admission could be due to organisational changes with increased admission to intermediate care units. These changes have to be understood to accurately use maternal CU admission for maternal health surveillance.
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50

De Nardi, Frédéric, Christophe Puaud, Thierry Lodé, Josiane Lecorff, Bernard Parinet, and Maxime Pontié. "Diagnostic préliminaire et perspectives d’élimination du phosphore (P) en excès dans le lac de Ribou (Cholet, Maine-et-Loire, France)." 23, no. 2 (June 7, 2010): 159–71. http://dx.doi.org/10.7202/039907ar.

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L’excès de phosphore (P) dans les eaux de retenues est responsable d’une prolifération de cyanobactéries. Cela s’observe fréquemment dans la plupart des pays européens. En France, le lac de Ribou, localisé à Cholet, est un cas typique (Maine-et-Loire) illustrant cette problématique. La présence de P est principalement liée aux rejets des stations d’épuration (STEP), situées sur le bassin versant, non équipées de processus de déphosphatation et également liées aux pratiques agricoles et aux élevages de bovins. Ainsi, la concentration moyenne de P total entrant dans le lac de Ribou par le Trézon sur l’année 2006 a été de 0,34 mg•L-1, ce qui en fait une eau de qualité « passable » et de nature « mésotrophe » alors que la retenue de Ribou a un caractère eutrophe. De plus, en matière de flux, il se déverse dans le lac de Ribou environ 18,7 tonnes de P•an-1. Sortir de l’eutrophisation reviendrait à abaisser cette valeur à 1 tonne de P•an-1, soit une concentration moyenne de P dans les eaux d’alimentation de la retenue de 0,03 mg•L-1. Pour sortir de cette situation, un plan de gestion dans le cadre du Schéma d’Aménagement de Gestion de l’Eau (SAGE) a démarré en 2006. Il comprend un ensemble de 29 mesures avec, en particulier, la mise en place de contrats agro-environnementaux permettant de réduire les surfaces en cultures au profit de surfaces en prairies, la réalisation de diagnostics agro-environnementaux sur 170 exploitations, l’organisation de journées de formation pour la plantation et l’entretien des haies, la prise en compte du phosphore dans les projets de modernisation des six STEP du bassin versant (non-rejet, déphosphatation, etc.), la mise en place de bandes enherbées, le suivi mensuel de la qualité de l’eau brute sur 16 points de prélèvement du bassin versant, l’organisation de réunions techniques auprès des acteurs concernés permettant la promotion de méthodologies visant à réduire le phosphore et la promotion de la « désintensification » des systèmes de production agricole. Enfin, parmi ces mesures, l’aménagement de zones humides tampons est envisagé dans le but de diminuer d’un facteur 10 les apports actuels d’ici 2010. Ainsi, une démarche de restauration a été mise en oeuvre. En effet, dans un premier temps, un diagnostic du lac de Ribou par analyse en composante principale sur un ensemble de données physico-chimiques a montré que la station la plus anthropisée correspond à la station TR qui doit faire l’objet de priorité dans le cadre d’un aménagement futur. Dans un second temps, au cours de l’année 2006, des inventaires floristiques ont été conduits sur cette zone de confluence entre le Trézon et le lac de Ribou, en appliquant la méthode des quadrats selon l’échelle de Braun-Blanquet. Nous avons mis en évidence 21 espèces végétales en mai et 12 en octobre. Parmi celles-ci, les espèces Juncus effusus, Phalaris arundinacea, Salix caprea, Rorippa amphibia, et Lemna minor ont été répertoriées. Ces inventaires ont permis, d’une part, de diagnostiquer l’état écologique du milieu aquatique à travers l’observation de la présence d’un ensemble caractéristique d’hélophytes appelé Phalaridaie regroupant les espèces Rorippa amphibia, Lycopus europaeus, Mentha aquatica, Phalaris arundinacea, Alisma plantago-aquatica et Lythrum salicaria. La présence de ce groupe caractéristique traduit une mauvaise qualité de l’eau brute. D’autre part, ces inventaires ont permis de mettre en évidence des espèces aquatiques potentiellement intéressantes dans l’épuration du phosphore comme Phalaris arundinacea, Salix caprea et Juncus effusus. Ces dernières pourraient être utilisées à moyen terme pour l’aménagement de zones tampons dans un but de restauration de la qualité des eaux du lac de Ribou.
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