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Dissertations / Theses on the topic 'Germinal centers'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 January 2023

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1

Dahlenborg, Katarina. "Celluar and molecular aspects of the germinal center reaction." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945013.html.

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2

Vonderheide, Robert H. "Formation of germinal centres in the rat." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:2a533d75-468a-44b0-a07c-60c6d8f6b17a.

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3

Wittenbrink, Nicole. "New perspectives on the evolution of B-lymphocytes in germinal centers." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15783.

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Ein zentrales Merkmal der humoralen Antwort ist die im Laufe der Zeit ansteigende Affinität der Antikörper gegenüber dem Antigen, ein Phänomen, das man generell als Affinitätsreifung bezeichnet. Die Affinitätsreifung von Antikörpern ist an die transiente Ausbildung von Keimzentren gebunden, die man nach Immunisierung mit einem T-Zell-abhängigen Antigen in sekundär lymphatischen Geweben wie der Milz beobachtet. Innerhalb der Keimzentren durchlaufen B-Zellen einen mikro-evolutionären Prozess, in dessen Verlauf es zu einer Diversifizierung der von den B-Zellen kodierten B-Zell-Rezeptoren durch so

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4

Alcantar, Eduardo C. Jr. "IDENTIFYING A POSSIBLE LINK BETWEEN ECTOPIC GERMINAL CENTERS AND THE EVOLUTION OF TYPE I DIABETES." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/348459.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>The multifaceted phenotype of the B‐lymphocyte has a remarkably effective role in peptide derived pathogen clearance and the prevention of re‐infection. This mechanism of host tolerant defense can be attributed to the actions of particular cellular subsets that arise from Blymphocytes: memory cells and high‐affinity antibody secreting plasma cells. Notably B cell propagation does not commence without the help of follicular helper

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5

Atkinson, Jeffrey Ross. "Peripheral Germinal Centers Regulate Virus-Specific B Cell Accumulation in the CNS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1524683244217474.

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6

Goldman, Lea Nichole. "Kinetics and phenotype of the draining lymph node and pulmonary B cell response to an influenza A virus-like particle vaccine." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4634.

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Influenza A virus (IAV) infection is a serious respiratory disease associated with significant morbidity and mortality worldwide. Annual vaccination is the most effective way to prevent infection and its potentially severe complications; however, the vaccines currently offered have several drawbacks that limit its availability and protective efficacy. Influenza virus-like particles (VLPs), which lack viral genetic material and are non-infectious, represent a promising vaccine candidate. Previous reports have shown VLPs are more immunogenic than subunit or recombinant proteins, and confer prote

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7

Sakamoto, Keiko. "Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice." Kyoto University, 2016. http://hdl.handle.net/2433/217734.

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8

Chaimowitz, Natalia. "The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/374.

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In these studies we sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In particular, ADAM10 has been identified as a key regulator of lymphocyte development. Here we report that ADAM10 is dispensable for early B cell development within the bone marrow. However, deletion of ADAM10 from all peripheral B c

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9

Hussein, Mourad. "Caractérisation des mécanismes cellulaires, génétiques et épigénétiques de la différenciation terminale des lymphocytes B chez l’homme." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S198.

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Ces dernières années ont été marquées par une progression importante dans la connaissance de la physiologie des cellules B in vivo et de leur différenciation en plasmocytes, grâce aux modèles murins et à l'imagerie intravitale. La transposition à l'Homme des connaissances acquises chez la souris soulève cependant des difficultés, telles que le manque d'outils pour visualiser les évènements qui se déroulent dans les organes lymphoïdes humains. Dans l'optique d'apporter une réponse à cette problématique, nous avons développé au sein du laboratoire un modèle in vitro en deux étapes, permettant la

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10

Eijk, Martinus Cornelis van. "Regulation of germinal center B cell apoptosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/83857.

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11

Alexander, Carla-Maria Alana. "T regulatory cells and the germinal center." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1117.

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Germinal center (GC) reactions are central features of T cell-driven B cell responses, and the site where antibody (Ab) producing cells and memory B cells are generated. Within GCs, a range of complex cellular and molecular events occur which are critical for the generation of high affinity Abs. These processes require exquisite regulation not only to ensure the production of desired Abs, but to minimize unwanted autoreactive or low affinity Abs. To assess whether T regulatory cells (Treg) participate in the control of GC responses, immunized mice were treated with either an anti-glucocorticoi

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12

Rastelli, Julia. "Latent Epstein-Barr virus infection and the germinal center reaction." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-105021.

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13

Allen, Christopher David Caballero. "Germinal center dark and light zone organization and cellular dynamics." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261258.

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Thesis (Ph.D.)--University of California, San Francisco, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2232. Adviser: Jason G. Cyster. Includes supplementary digital materials.

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14

Mueller, Thomas. "Systems for measuring B cell receptor affinity maturation in germinal centres." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7130/.

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Germinal Centres (GCs) play a central role in adaptive immunity; involving processes of cell migration, clonal expansion, hypermutation, and selection. To elucidate the role of affinity in regulating these processes, a technique for measuring B cell receptor affinity maturation in GCs in situ was developed. To facilitate interrogation of individual antibody-antigen interactions, atomic force microscopy (AFM) was chosen, offering nanometre positional resolution, and pico-Newton force sensitivity. Specificity of gold-coated AFM cantilevers towards the targeted receptors was achieved via a bespok

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15

Supple, Emma Alissa. "The role of germinal centres in the pathogenesis of bovine viral diarrhoea virus." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367617.

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16

Villegas, Vázquez José Adolfo. "Targeting the IL-23/Th17 pathway to treat Myasthenia Gravis." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS393.

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La myasthénie grave (MG) est une maladie auto-immune neuromusculaire due à des autoanticorps dirigés contre les récepteurs à l’acétylcholine. Le thymus MG est inflammatoire. Il possède des centres germinatifs, site de production des auto-anticorps et une surexpression de cytokines favorisant le développement de lymphocytes Th17. Associé à ce cocktail cytokinique, l’IL-23 favorise l’émergence de lymphocytes Th17 délétères. Les objectifs de ma thèse ont été de 1) Déterminer les rôles de la voie IL-23/Th17 dans les évènements thymiques pathogéniques. 2) d’identifier, in vivo, les effets bénéfique

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17

Palacios, Arnold Raul. "Role of GSK-3 alpha beta in B cell proliferation during germinal center information." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21229.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Glycogen Synthase Kinase-3αß is an enzyme that is involved in cell cycle regulation by promoting the degradation of cyclin D1 and cycling D3 in cells. Special emphasis is placed in its regulatory role in B cells, as there it is evi

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18

Townsend, William Mathew. "A study of CD4+ follicular helper T cells in the follicular lymphoma microenvironment and normal germinal centres." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-cd4-follicular-helper-t-cells-in-the-follicular-lymphoma-microenvironment-and-normal-germinal-centres(744b7c2f-f848-4c41-8fd1-687dc2201f6b).html.

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Follicular lymphoma is a common B cell malignancy which usually follows an indolent course but it is a heterogeneous disease and there are no biomarkers that can accurately predict outcome or prognosis at the time of diagnosis. There is now clear evidence that the microenvironment plays an important role in the pathogenesis of this disease and the composition of the microenvironment has been linked to prognosis with variable results. The biological basis for the influence of the microenvironment and the contribution of individual cell types remain unclear. In this research we focus on CD4+ T c

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19

Miles, Brodie, Shannon M. Miller, Joy M. Folkvord, et al. "Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection." PUBLIC LIBRARY SCIENCE, 2016. http://hdl.handle.net/10150/622413.

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During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles. Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle. Here, we show CXCR5(hi)CD44(hi)CD8 T cells are a regulatory subset differing from conventional CD8 T cells, and constitute the majority of CD8 T cells in the follicle. This subset, CD8 follicular regulatory T cells (CD8 T-FR), expand in chronic SIV infection, exhibit enhanced expression of Tim-3 and IL-10, and express less perforin compared to conventional CD8 T cells. CD8 T-FR modestly limit HIV repl

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20

Ramis, Zaldívar Juan Enrique. "Decoding the genetic landscape of pediatric and young adult germinal center-derived B-cell non-Hodgkin lymphoma." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672372.

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B-cell non-Hodgkin lymphoma (B-NHL) of pediatric and young adult population is a diverse group of neoplasms predominantly composed of aggressive B-cell lymphomas from the germinal center (GC). Molecular characterization of pediatric series has allowed the identification of several subtypes that predominantly occur in this subgroup of age. Despite of that, genomic features of these pediatric entities and their relationship to other B-NHL in this group of patients have not been extensively investigated. This thesis has aimed to address this gap of knowledge by performing a genetic and molecular

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21

Le, Thuc-vy L. "B cell clonal abundance and madcam-1 mediate affinity maturation and fate of germinal center B cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/le.pdf.

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22

Mello, Celso Abdon Lopes de. "Análise de CD10, BCL-6 e MUM1 em linfomas não Hodgkin de células B primários de mediastino." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-02062010-161354/.

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INTRODUÇÃO: Os linfomas B atualmente podem ser agrupados de acordo semelhanças moleculares e imunoistoquímicas com o linfócito do centro germinativo (CG) ou linfócito ativado (LA/pós CG), sendo este de pior prognóstico. O objetivo deste trabalho foi analisar a expressão de CD10, BCL-6 e MUM1 em pacientes portadores de LBPM e correlacionar com prognóstico. MÉTODOS: análise retrospectiva das variáveis clínicas e de tratamento de 44 pacientes portadores de LBPM. Estudo imunoistoquímico de CD10, BCL-6 e MUM1 em 29 pacientes com material disponível. RESULTADOS: idade mediana foi de 28 anos e 70% er

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23

Arulraj, Theinmozhi [Verfasser], Michael [Akademischer Betreuer] Meyer-Hermann, and Stefan [Akademischer Betreuer] Dübel. "In silico analysis of the mechanism and regulation of germinal center shutdown / Theinmozhi Arulraj ; Michael Meyer-Hermann, Stefan Dübel." Braunschweig : Technische Universität Braunschweig, 2021. http://d-nb.info/1241245762/34.

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24

Trabucco, Sally E. "The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/864.

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Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin’s lymphoma. Patients who fail conventional therapy (~50%) have a poor prognosis and few treatment options. It is essential to understand the underlying biological processes, the progression of the disease, and utilize this information to develop new therapeutics. DLBCL patients with high C-MYC expression have a poor prognosis and new therapeutics for these patients are needed. This thesis describes work testing the hypothesis that JQ1, which can indirectly inhibit C-MYC in some tumors, can be used as an effective treatment fo

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25

Alexander, Lou-Ella M. m. "Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7119.

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The studies presented in this dissertation establish the dynamics of Eleven nineteen Lysine-rich leukemia (ELL) family of elongation factors during B cell differentiation and provide a description of ELL3 function in B cells. The transition from a mature naïve B cells into an activated B cell is dependent on a large increase in transcriptional output, which is followed by focused expression on secreted immunoglobulin upon terminal differentiation into plasma cell. While ELL family members have previously been implicated in alternative splicing at the immunoglobulin heavy chain locus in plasma

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26

El, Sayed Rania. "ROLE OF FDCs AND FDC ACTIVATION IN PROMOTING HUMORAL IMMUNITY INCLUDING RESPONSES TO T-DEPENDENT ANTIGENS IN THE ABSENCE OF T CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1927.

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Follicular dendritic cells (FDCs) reside in primary B-cell follicles and in the light zones of germinal centers (GCs) in secondary follicles, where their dendrites interdigitate forming extensive networks intimately interacting with B-cells. In GCs, FDCs can be found at the edges attached to the supporting reticular fibers. They trap and arrange immune complexes (ICs) in vivo and in vitro in a periodic manner with 200–500Å spacing and provide both antigen-specific and non-specific accessory signals to B-cells. FDCs exist in resting and activated states, with two characteristically different ph

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27

Zander, Linda. "The germinal centre reaction : genetic and proteomic analysis of factors important for survival and growth of B lymphocytes /." Göteborg : Dept. of Microbiology and Immunology, Sahlgrenska Academy, Göteborg University, 2008. http://hdl.handle.net/2077/9505.

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28

Wang, Xuan. "Function of M4 protein in vitro and in vivo." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8195.

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Herpesviruses are ubiquitous in both humans and animals and can cause life-threatening disease. The discovery of murine gammaherpesvirus 68 (MHV-68), which has many similarities in genome and pathogenesis as the human pathogens Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, provides a model for further investigation of the pathogenesis of gammaherpesviruses. The M4 gene was found to be at the left end region of MHV-68 genome. The presence of the M4 protein is required during the early establishment of MHV-68 latency. However, the function of M4 protein remains unclear. The aim

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29

Valai, Atijeh [Verfasser]. "Migration and differentiation of murine germinal center derived B cell subsets in the course of the NP-specific immune response / Atijeh Valai." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/102985081X/34.

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30

Muramatsu, Masamichi. "Specific expression of activation-induced cytidine deaminase(AID), a novel member of the RNA editing deaminase family in germinal center B cells." Kyoto University, 1999. http://hdl.handle.net/2433/181236.

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31

Sakai, Tomomi. "Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type." Kyoto University, 2010. http://hdl.handle.net/2433/120565.

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32

Wei, Ruicheng. "Etudes des mécanismes cellulaires et moléculaires de la réponse immunitaire de type 2 dans la dermatite atopique." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ047.

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Mon travail, lors de ma thèse, avait pour but d’étudier la différentiation des lymphocytes Tfh, ainsi que leur fonction et leur régulation dans la pathogenèse de la DA. Pour cela, j’ai utilisé un modèle murin précédemment établi au sein de notre laboratoire consistant en l’application topique de MC903 (un analogue de la vitamine D3) induisant la production de TSLP par les kératinocytes et, par conséquence, la réponse immunitaire Th2 et la pathogenèse de la DA. mon travail doctoral s’est porté sur la différentiation des lymphocytes Tfh, leur production cytokinique ainsi que la formation des cen

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33

Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.

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34

Miles, Brodie, Shannon M. Miller, and Elizabeth Connick. "CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection." FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/622733.

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T follicular helper cells (T-FH) are a specialized subset of CD4 T cells that reside in B cell follicles and promote B cell maturation into plasma cells and long-lived memory B cells. During chronic infection prior to the development of AIDS, HIV-1 (HIV) replication is largely concentrated in T-FH. Paradoxically, T-FH numbers are increased in early and midstages of disease, thereby promoting HIV replication and disease progression. Despite increased T-FH numbers, numerous defects in humoral immunity are detected in HIV-infected individuals, including dysregulation of B cell maturation, impaire

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35

Ren, Jingjing. "The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/93590.

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Systemic lupus erythematosus (SLE) is a chronic multifactorial inflammatory autoimmune disease with heterogeneous clinical manifestations. Among different manifestations, lupus nephritis (LN) remains a major cause of morbidity and mortality. There are few FDA approved treatments for LN. In general, they are non-selective and lead to global immunosuppression with significant side effects including an increased risk of infection. In the past 60 years, only one new drug, belimumab was approved for lupus disease with modest efficacy in clinic and not approved for patients suffering for nephritis.

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Vanderleyden, Ine. "Follicular regulatory T cell migration and differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288422.

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The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through which they exert their suppressive function. At the outset of this work, the major barrier to un

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Ogbe, Ane Theodora. "Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11214.

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The Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system. These transcription factors have reported functions in T cell receptor signaling, differentiation of effector T cell subsets and the development of lupus-like autoimmune diseases. Using CD2-Egr2-/- Egr3-/- mouse model, I investigate the development of inflammation pathology, differentiation of T follicular helper (Tfh) cells and the formation of germinal centers (GC) following viral challenge within these mice. The onset of inflammation pathology in CD2-Egr2-

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Boyden, Alexander Wiser. "Influenza A virus induces regulated T cell-driven B cell responses." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3432.

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Protection from influenza A virus (IAV) challenge requires switched, high affinity Abs derived from long-lived memory B cells and plasma cells. These subsets are generated in germinal centers (GCs), hallmark structures of T helper cell-driven B cell immunity. A full understanding of the acute and persistent GC B cell reaction following respiratory IAV infection is lacking, as is the characterization of IAV-induced T follicular helper (TFH) cells that support GCs. Additionally, it remains unclear as to whether IAV-induced GC B cells are subject to control by regulatory T cells (Tregs). To addre

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Town, Jennifer [Verfasser], Arnd Akademischer Betreuer] Kieser, and Dieter [Akademischer Betreuer] [Langosch. "Functions of the germinal center kinase TNIK in signal transduction of the viral oncoprotein LMP1 and the related CD40 receptor / Jennifer Town. Gutachter: Dieter Langosch. Betreuer: Arnd Kieser." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1030100144/34.

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Hadife, Nader. "Interleukine-24 : rôle immunologique et mécanismes d'induction de mort cellulaire dans les lymphocytes B." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0018/document.

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Notre équipe a précédemment démontré que l'Interleukine (IL)-24 une cytokine de la famille de l'IL-10 a un effet cytostatique voire cytotoxique sur des cellules B normales ou leucémiques mises préalablement en cycle mais non sur des cellules quiescentes. L'IL-24 inhibe également la différenciation plasmocytaire des cellules B humaines du centre germinatif dans un modèle de différentiation in vitro. Nous avons utilisé ce modèle pour analyser pour la première fois le transcriptome de cellules B stimulées ou non par IL-24 au bout de 6 et 36 h. Plusieurs transcrits impliqués dans le métabolisme et

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Santamaria, Kathleen. "Etude de l’hétérogénéité des centrocytes humains à travers l’expression du CD23 : différenciation en plasmablastes et expression d’une signature minimale transcriptionnelle au niveau cellule-unique comportant DEC2." Thesis, Rennes 1, 2020. http://www.theses.fr/2020REN1B038.

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La différenciation terminale des lymphocytes B à travers le centre germinatif conduit à la production de cellules sécrétrices d’anticorps : les plasmocytes (PC) à longue durée de vie et de haute affinité pour l’antigène. Cette réaction implique la formation d’une microstructure anatomique qui comprend une zone sombre : lieu d’intenses proliférations des centroblastes et de maturation d’affinité de leur BCR, et une zone claire dans laquelle ont lieu les commutations de classes isotypiques du BCR et la sélection des centrocytes (CC). Ce processus est finement contrôlé par les lymphocytes T folli

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42

Le, Coz Carole. "Quelle contribution du centre germinatif et de ses composants moléculaires et cellulaires dans la physiopathologie du lupus ?" Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ077.

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Le lupus érythémateux disséminé est une maladie auto-immune systémique très invalidante dont les atteintes sont multiples, les plus fréquentes étant cutanées, articulaires et rénales. Dans ce type de maladie, le système immunitaire, hyperactif, ne se limite pas à lutter contre des agents extérieurs mais s'attaque à ses propres cellules, entre autres par le biais d'auto-anticorps. Ces anticorps délétères sont produits par des plasmocytes, cellules issus de la différenciation des lymphocytes B. Ce processus se déroule principalement au sein des centres germinatifs (GC) dans les organes lymphoïde

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Weber, Tom. "Optimal timing of phase resolved cell cycle progression." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://dx.doi.org/10.18452/17253.

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Selbstreproduktion ist eines der Kennzeichen aller lebenden Organismen. Der Zellzyklus dient der Selbstreproduktion in einzelligen Organismen. In mehrzelligen Organismen ist der Zellzyklus darüber hinaus für andere lebenswichtige Prozesse, einschließlich Immunreaktionen, unerlässlich. In dieser Arbeit wird eine Methode entwickelt mit der die Dauer der Zellzyklus Phasen bestimmt werden kann. Kenntnis über die Zellzyklusphasendauer ermöglicht vorherzusagen, wie schnell eine Population von proliferierenden Zellen wachsen wird, oder wie viele neue Zellen pro Stunde in einem Gewebe geboren werden.

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Alyafei, Saud Abdalla Mubarak Mohamed. "Study of the reactivity of a monoclonal antibody that recognises human marginal zone B cells and a subset of germinal centre cells in tissue sections." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/study-of-the-reactivity-of-a-monoclonal-antibody-that-recognises-human-marginal-zone-b-cells-and-a-subset-of-germinal-centre-cells-in-tissue-sections(7fcf0edc-b729-4215-ae52-a9e2d2622493).html.

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Marginal Zone (MZ) cells are a subset of B cells. They reside the marginal zone outside the mantle zone of the spleen and circulate the blood in humans. They have also been identified in the crypt epithelium of tonsil, the sub-capsular sinus in lymph node and in the dome area of Peyer’s patches in gut-associated lymphoid tissue of human intestine. A monoclonal antibody (4D12) that recognises an antigen on MZ B cells and a subset of GC cells in tissue sections has been described previously but this has not been investigated in detail and features of the 4D12 antigen and the lymphocytes that exp

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Yang, Liqun. "Characterization of the Physiologic Function of NF-κB2 p100". University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1263334529.

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Nzengue, Bleck Ulrich. "L'enfance malheureuse et ses espaces au XIXème siècle, entre textes et images : François le Champi, Le Petit Chose et Germinal." Thesis, Université Clermont Auvergne‎ (2017-2020), 2020. http://www.theses.fr/2020CLFAL010.

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Cette thèse vise à étudier la représentation de l’enfance malheureuse et ses espaces dans François le Champi (1848), Le Petit Chose (1868) et Germinal (1885), et à travers la relation textes-images. Il s’agit de montrer comment George Sand, Alphonse Daudet et Émile Zola abordent cette thématique dans leurs œuvres. La relation textes-images est traitée à l’aide de plusieurs éditions illustrées qui renouvellent la lecture de ces romans. L’enjeu est de démontrer que certes les œuvres sont écrites à des périodes différentes et s’inscrivent dans des contextes et des esthétiques variés, mais qu’il e

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Acs, Andreas [Verfasser], Thomas [Akademischer Betreuer] Winkler, and Thomas [Gutachter] Winkler. "A model for interclonal competition in the germinal center: Dynamic selection processes by-pass the affinity dead-end of low affinity anti-NP specific B cells / Andreas Acs ; Gutachter: Thomas Winkler ; Betreuer: Thomas Winkler." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1179450434/34.

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Radchenko, Daria [Verfasser], Ulrich Gutachter] Kück, and Dominik [Gutachter] [Begerow. "Cellular signaling pathways in the filamentous fungus Sordaria macrospora : molecular genetic analysis of the STRIPAK-associated germinal center kinase SmKIN3 in developmental processes / Daria Radchenko ; Gutachter: Ulrich Kück, Dominik Begerow ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1163451886/34.

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Radchenko, Daria Verfasser], Ulrich [Gutachter] Kück, and Dominik [Gutachter] [Begerow. "Cellular signaling pathways in the filamentous fungus Sordaria macrospora : molecular genetic analysis of the STRIPAK-associated germinal center kinase SmKIN3 in developmental processes / Daria Radchenko ; Gutachter: Ulrich Kück, Dominik Begerow ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1163451886/34.

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Xia, Lijin. "Regulators of G-protein Signaling, RGS13 and RGS16, are Associated with CXCL12-mediated CD4+ T Cell Migration." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2588.pdf.

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