Log in

Relevant bibliographies by topics / Germinal centers / Journal articles

To see the other types of publications on this topic, follow the link: Germinal centers.

Journal articles on the topic 'Germinal centers'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Germinal centers.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Shlomchik, Mark J., and Florian Weisel. "Germinal centers." Immunological Reviews 247, no. 1 (2012): 5–10. http://dx.doi.org/10.1111/j.1600-065x.2012.01125.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Victora, Gabriel D., and Michel C. Nussenzweig. "Germinal Centers." Annual Review of Immunology 30, no. 1 (2012): 429–57. http://dx.doi.org/10.1146/annurev-immunol-020711-075032.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

MacLennan, Ian C. M. "Germinal Centers." Annual Review of Immunology 12, no. 1 (1994): 117–39. http://dx.doi.org/10.1146/annurev.iy.12.040194.001001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Manser, Tim. "Textbook Germinal Centers?" Journal of Immunology 172, no. 6 (2004): 3369–75. http://dx.doi.org/10.4049/jimmunol.172.6.3369.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Visan, Ioana. "Hypoxic germinal centers." Nature Immunology 17, no. 11 (2016): 1243. http://dx.doi.org/10.1038/ni.3594.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Arakawa, Hiroshi, Kei-ichi Kuma, Masahiro Yasuda, Shuichi Furusawa, Shigeo Ekino, and Hideo Yamagishi. "Oligoclonal Development of B Cells Bearing Discrete Ig Chains in Chicken Single Germinal Centers." Journal of Immunology 160, no. 9 (1998): 4232–41. http://dx.doi.org/10.4049/jimmunol.160.9.4232.

Full text

Abstract:

Abstract Chicken single germinal centers enable us to analyze the postbursal diversifications of B cells due to their easy isolation. Germinal center formation has peaked by day 7 of primary responses and begins to wane 14 days after immunization. To detail the kinetics of Ig mutation and selection, we analyzed Ig light chain sequences recovered from single germinal centers at 7 and 11 days postimmunization with an artificial Ag. Our observations show that multiple, Ag-activated B cells migrating into single germinal centers are diversified by gene conversion in the very early phase of the ger

APA, Harvard, Vancouver, ISO, and other styles

7

Toellner, Kai-Michael, William E. Jenkinson, Dale R. Taylor, et al. "Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers." Journal of Experimental Medicine 195, no. 3 (2002): 383–89. http://dx.doi.org/10.1084/jem.20011112.

Full text

Abstract:

Exceptionally germinal center formation can be induced without T cell help by polysaccharide-based antigens, but these germinal centers involute by massive B cell apoptosis at the time centrocyte selection starts. This study investigates whether B cells in germinal centers induced by the T cell–independent antigen (4-hydroxy-3-nitrophenyl)acetyl (NP) conjugated to Ficoll undergo hypermutation in their immunoglobulin V region genes. Positive controls are provided by comparing germinal centers at the same stage of development in carrier-primed mice immunized with a T cell–dependent antigen: NP p

APA, Harvard, Vancouver, ISO, and other styles

8

de Vinuesa, Carola García, Matthew C. Cook, Jennifer Ball, et al. "Germinal Centers without T Cells." Journal of Experimental Medicine 191, no. 3 (2000): 485–94. http://dx.doi.org/10.1084/jem.191.3.485.

Full text

Abstract:

Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen. This process can change Ab affinity and specificity. The mutated cells that produce high-affinity Ab are selected to become Ab-forming or memory B cells, whereas cells that have lost affinity or acquired autoreactivity are eliminated. Normally, T cells are critical for germi

APA, Harvard, Vancouver, ISO, and other styles

9

He, Yuke, and Carola G. Vinuesa. "Monocytes asphyxiate germinal centers." Immunity 55, no. 3 (2022): 385–87. http://dx.doi.org/10.1016/j.immuni.2022.02.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Young, Clara, and Robert Brink. "Germinal centers and autoantibodies." Immunology & Cell Biology 98, no. 6 (2020): 480–89. http://dx.doi.org/10.1111/imcb.12321.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Dempsey, Laurie A. "Dopamine in germinal centers." Nature Immunology 18, no. 9 (2017): 961. http://dx.doi.org/10.1038/ni.3825.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kroese, Frans G. M., Auk S. Wubbena, Hendrik G. Seijen, and Paul Nieuwenhuis. "Germinal centers develop oligoclonally." European Journal of Immunology 17, no. 7 (1987): 1069–72. http://dx.doi.org/10.1002/eji.1830170726.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. "In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells." Journal of Experimental Medicine 178, no. 4 (1993): 1293–307. http://dx.doi.org/10.1084/jem.178.4.1293.

Full text

Abstract:

In the murine spleen, germinal centers are the anatomic sites for antigen-driven hypermutation and selection of immunoglobulin (Ig) genes. To detail the kinetics of Ig mutation and selection, 178 VDJ sequences from 16 antigen-induced germinal centers were analyzed. Although germinal centers appeared by day 4, mutation was not observed in germinal center B cells until day 8 postimmunization; thereafter, point mutations favoring asymmetrical transversions accumulated until day 14. During this period, strong phenotypic selection on the mutant B lymphocytes was inferred from progressively biased d

APA, Harvard, Vancouver, ISO, and other styles

14

Özkan, Melda Cömert, Nazan Özsan, Mine Hekimgil, Güray Saydam, and Mahmut Töbü. "Progressive Transformation of Germinal Centers: Single Center Experience." Clinical Lymphoma Myeloma and Leukemia 15 (September 2015): S39. http://dx.doi.org/10.1016/j.clml.2015.07.082.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Stengel, Kristy R., Srividya Bhaskara, Jing Wang, et al. "Histone deacetylase 3 controls a transcriptional network required for B cell maturation." Nucleic Acids Research 47, no. 20 (2019): 10612–27. http://dx.doi.org/10.1093/nar/gkz816.

Full text

Abstract:

Abstract Histone deacetylase 3 (Hdac3) is a target of the FDA approved HDAC inhibitors, which are used for the treatment of lymphoid malignancies. Here, we used Cd19-Cre to conditionally delete Hdac3 to define its role in germinal center B cells, which represent the cell of origin for many B cell malignancies. Cd19-Cre-Hdac3−/− mice showed impaired germinal center formation along with a defect in plasmablast production. Analysis of Hdac3−/− germinal centers revealed a reduction in dark zone centroblasts and accumulation of light zone centrocytes. RNA-seq revealed a significant correlation betw

APA, Harvard, Vancouver, ISO, and other styles

16

Stoler-Barak, Liat, and Ziv Shulman. "Getting toGether in Germinal centers." Science Immunology 6, no. 60 (2021): eabi9749. http://dx.doi.org/10.1126/sciimmunol.abi9749.

Full text

Abstract:

In this issue of Science Immunology, Gallman et al. reveal how S-geranylgeranyl-l-glutathione cleavage and transport support P2RY8-driven B cell confinement to the germinal centers and its role in lymphocyte homing to the bone marrow.

APA, Harvard, Vancouver, ISO, and other styles

17

Domeier, Phillip P., Stephanie L. Schell, and Ziaur S. M. Rahman. "Spontaneous germinal centers and autoimmunity." Autoimmunity 50, no. 1 (2017): 4–18. http://dx.doi.org/10.1080/08916934.2017.1280671.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Verma, Amit, Wendy Stock, Sandhya Norohna, Rajul Shah, Basil Bradlow, and Leonidas C. Platanias. "Progressive Transformation of Germinal Centers." Acta Haematologica 108, no. 1 (2002): 33–38. http://dx.doi.org/10.1159/000063057.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Tarlinton, David. "Germinal centers: form and function." Current Opinion in Immunology 10, no. 3 (1998): 245–51. http://dx.doi.org/10.1016/s0952-7915(98)80161-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

MacLennan, Ian C. M. "Germinal Centers Still Hold Secrets." Immunity 22, no. 6 (2005): 656–57. http://dx.doi.org/10.1016/j.immuni.2005.06.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Moschovakis, G. Leandros, and Reinhold Förster. "Repulsive behavior in germinal centers." Science 356, no. 6339 (2017): 703–4. http://dx.doi.org/10.1126/science.aan5222.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Licup, Ana T., Paolo Campisi, Bo-Yee Ngan, and Vito Forte. "Progressive Transformation of Germinal Centers." Archives of Otolaryngology–Head & Neck Surgery 132, no. 7 (2006): 797. http://dx.doi.org/10.1001/archotol.132.7.797.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Maurer, Daniel P., and Aaron G. Schmidt. "Invasion of the germinal centers." Cell 186, no. 1 (2023): 12–14. http://dx.doi.org/10.1016/j.cell.2022.12.023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Tan, Lu Ping, Miao Wang, Jan-Lukas Robertus, et al. "miRNA Profiling of B Cell Subsets: Specific miRNA Profile for Germinal Center B Cells with a Marked Variation Between Centroblast and Centrocytes." Blood 112, no. 11 (2008): 1459. http://dx.doi.org/10.1182/blood.v112.11.1459.1459.

Full text

Abstract:

Abstract MiRNAs are a new class of small RNAs, of 19–23 nucleotides that were discovered less than two decades ago. These tiny RNAs can negatively regulate genes at the post-transcriptional level by either triggering translational repression or direct cleavage of mRNAs. It has become evident that miRNAs are involved in hematopoiesis and that the aberrant expression of miRNAs may give rise to hematopoietic malignancies. The aim of our study was to characterize the miRNA profile of naïve, germinal center and memory B cells sorted from tonsils and review expression of selected miRNAs in tonsils

APA, Harvard, Vancouver, ISO, and other styles

25

Barrington, Robert, Janet Buhlmann, Xiaogan Wang, Amber Bartlett, Bing Lim, and William Smith. "CD275/ICOSL-independent germinal centers and autoantibody in autoimmune-prone RasGRP1-deficient mice (BA13P.125)." Journal of Immunology 192, no. 1_Supplement (2014): 177.11. http://dx.doi.org/10.4049/jimmunol.192.supp.177.11.

Full text

Abstract:

Abstract Lymphopenia results in favorable microenvironments for the expansion and activation of autoreactive lymphocytes. Mice deficient in guanine nucleotide exchange factor Rasgrp1 (KO) are T lymphopenic early in life and develop a lymphoproliferative disorder with features of human SLE. Our previous work revealed that autoreactive B cells lacking RasGRP1 break tolerance early during development as well as during germinal center responses, suggesting both T cell-independent and -dependent mechanisms are responsible. To understand whether T cells are involved in the breach of tolerance in ger

APA, Harvard, Vancouver, ISO, and other styles

26

Agarwal, Anshu, Bishnu P. Nayak, and Kanury V. S. Rao. "B Cell Responses to a Peptide Epitope. VII. Antigen-Dependent Modulation of the Germinal Center Reaction." Journal of Immunology 161, no. 11 (1998): 5832–41. http://dx.doi.org/10.4049/jimmunol.161.11.5832.

Full text

Abstract:

Abstract Germinal center responses to two analogous peptides, PS1CT3 and G32CT3, that differ in sequence only at one position within the B cell epitopic region were examined. In comparison with peptide PS1CT3, peptide G32CT3 elicited a poor germinal center response. By demonstrating equal facility of immune complexes with IgM and IgG Ab isotypes to seed germinal centers, we excluded differences in isotype profiles of early primary anti-PS1CT3 and anti-G32CT3 Ig as the probable cause. Quantitative differences in germinal center responses to the two peptides were also not due to either qualitati

APA, Harvard, Vancouver, ISO, and other styles

27

Johansson-Lindbom, Bengt, Sigurdur Ingvarsson, and Carl A. K. Borrebaeck. "Germinal Centers Regulate Human Th2 Development." Journal of Immunology 171, no. 4 (2003): 1657–66. http://dx.doi.org/10.4049/jimmunol.171.4.1657.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Bashyam, Hema. "Germinal centers are free for all." Journal of Experimental Medicine 204, no. 11 (2007): 2497. http://dx.doi.org/10.1084/jem.20411iti2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Ferry, Judith A., Lawrence R. Zukerberg, and Nancy L. Harris. "Florid Progressive Transformation of Germinal Centers." American Journal of Surgical Pathology 16, no. 3 (1992): 252–58. http://dx.doi.org/10.1097/00000478-199203000-00005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Degn, Søren E., Cees E. van der Poel, Daniel J. Firl, et al. "Clonal Evolution of Autoreactive Germinal Centers." Cell 170, no. 5 (2017): 913–26. http://dx.doi.org/10.1016/j.cell.2017.07.026.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Imamura, Keiko, Masahiro Yasuda, Brigitte Riwar, Seiji Inui, and Shigeo Ekino. "Characteristic cellular composition of germinal centers." Comparative Immunology, Microbiology and Infectious Diseases 32, no. 5 (2009): 419–28. http://dx.doi.org/10.1016/j.cimid.2007.12.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Visan, Ioana. "NF-κB flavors in germinal centers". Nature Immunology 15, № 11 (2014): 1008. http://dx.doi.org/10.1038/ni.3017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Arulraj, Theinmozhi, Sebastian C. Binder, and Michael Meyer-Hermann. "Antibody Mediated Intercommunication of Germinal Centers." Cells 11, no. 22 (2022): 3680. http://dx.doi.org/10.3390/cells11223680.

Full text

Abstract:

Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs). This suggests that GCs might intercommunicate via naturally produced soluble antibodies, but the role of such GC–GC interactions is unknown. In this study, we performed in silico simulations of interacting GCs and predicted that intense interactions by soluble antibodies limit the magnitude and lifetime of GC responses. With asynchronous GC onset, we

APA, Harvard, Vancouver, ISO, and other styles

34

Han, S., K. Hathcock, B. Zheng, T. B. Kepler, R. Hodes, and G. Kelsoe. "Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers." Journal of Immunology 155, no. 2 (1995): 556–67. http://dx.doi.org/10.4049/jimmunol.155.2.556.

Full text

Abstract:

Abstract Costimulatory interactions between T and B lymphocytes are crucial for T cell activation and B cell proliferation and differentiation. We have compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the early (days -1 to 3) or late (days 6-10) phases of primary responses to thymus-dependent (Td) and -independent (Ti) Ags. Germinal center (GC) formation in response to a Td Ag was inhibited completely by the early administration of anti-CD40L or anti-B7-2 Abs. Later in the response, establishe

APA, Harvard, Vancouver, ISO, and other styles

35

Rajnai, Hajnalka, Ivett Teleki, Gergo Kiszner, et al. "Connexin 43 Communication Channels in Follicular Dendritic Cell Development and in Follicular Lymphomas." Journal of Immunology Research 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/528098.

Full text

Abstract:

Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop abnormally. Here we tested Cx43 channels in reactive FDC development and follicular lymphomas. In culture, the treatment of FDC-B cell clusters (resembling to “ex vivo” germinal centers) with Gap27 peptide, mimicking the 2nd extracellular loop of Cx43 protein, significantly impaired FDC-B cell cluster formation and cell survival. In untreated

APA, Harvard, Vancouver, ISO, and other styles

36

Krenacs, Tibor, and Martin Rosendaal. "Gap-Junction Communication Pathways in Germinal Center Reactions." Developmental Immunology 6, no. 1-2 (1998): 111–18. http://dx.doi.org/10.1155/1998/45913.

Full text

Abstract:

Intercellular channels called gap junctions enable multicellular organisms to exchange information rapidly between cells. Though gap junctions are held to be ubiquitous in solid tissues, we have only recently found them in the lymphoid organs. Functional direct cell-cell communication has now been confirmed by us and other groups in bone marrow, thymus, and in secondary lymphoid tissues. What functions do they serve in the lymphoreticular system where, so far, only cytokines/growth factors and adhesion molecules have been considered as regulators? Here we show evidence for and refer to publish

APA, Harvard, Vancouver, ISO, and other styles

37

Oliver, A. M., F. Martin, and J. F. Kearney. "Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells." Journal of Immunology 158, no. 3 (1997): 1108–15. http://dx.doi.org/10.4049/jimmunol.158.3.1108.

Full text

Abstract:

Abstract Germinal center formation is the result of antigenic stimulation of B cells in a T cell-rich area. B cells cycle through the germinal centers, and a small percentage survive to become plasma cells or memory B cells. The transformation from a mature B cell into a germinal center B cell and finally into a terminally differentiated B cell is not well understood. Human CD38 is highly expressed on both germinal center B cells and plasma cells, and is useful in delineating these B cell subsets and in understanding the signaling events involved in the development of these B cells. To determi

APA, Harvard, Vancouver, ISO, and other styles

38

Fyfe, G., J. A. Cebra-Thomas, E. Mustain, J. M. Davie, C. D. Alley, and M. H. Nahm. "Subpopulations of B lymphocytes in germinal centers." Journal of Immunology 139, no. 7 (1987): 2187–94. http://dx.doi.org/10.4049/jimmunol.139.7.2187.

Full text

Abstract:

Abstract With two new monoclonal antibodies and flow cytometry, we defined three subpopulations among B cells expressing binding sites for peanut agglutinin (i.e., B cells of the germinal center). On monoclonal antibody (5B5) binds globotriaosyl ceramide. The B lymphocytes binding 5B5 have binding sites for peanut agglutinin on the surface and express only small amounts of sIgD and sIgM. When tested against a panel of B cell lines, only Burkitt's lymphoma cells were 5B5+. Moreover, the 5B5+ cells have larger average sizes and a large fraction of proliferating cells. The other monoclonal antibo

APA, Harvard, Vancouver, ISO, and other styles

39

İkincioğulları, Aykut. "Cervical lymphadenopathy: progressive transformation of germinal centers." Turkish Journal of Ear Nose and Throat 23, no. 5 (2013): 307–11. http://dx.doi.org/10.5606/kbbihtisas.2013.79966.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Degn, Søren E., Cees E. van der Poel, and Michael C. Carroll. "Targeting autoreactive germinal centers to curb autoimmunity." Oncotarget 8, no. 53 (2017): 90624–25. http://dx.doi.org/10.18632/oncotarget.21701.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Tas, J. M. J., L. Mesin, G. Pasqual, et al. "Visualizing antibody affinity maturation in germinal centers." Science 351, no. 6277 (2016): 1048–54. http://dx.doi.org/10.1126/science.aad3439.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Thorbecke, G. J., A. R. Amin, and V. K. Tsiagbe. "Biology of germinal centers in lymphoid tissue." FASEB Journal 8, no. 11 (1994): 832–40. http://dx.doi.org/10.1096/fasebj.8.11.8070632.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Kelsoe, Garnett. "Life and Death in Germinal Centers (Redux)." Immunity 4, no. 2 (1996): 107–11. http://dx.doi.org/10.1016/s1074-7613(00)80675-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Tarlinton, David. "Germinal centers: A second childhood for lymphocytes." Current Biology 7, no. 3 (1997): R155—R159. http://dx.doi.org/10.1016/s0960-9822(97)70077-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Victora, Gabriel D., and Luka Mesin. "Clonal and cellular dynamics in germinal centers." Current Opinion in Immunology 28 (June 2014): 90–96. http://dx.doi.org/10.1016/j.coi.2014.02.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Quizon, Nicolas, Kihyuck Kwak, Shivem Shah, Ankur Singh, and Susan Pierce. "Bioengineered organoid models of human germinal centers." Journal of Immunology 200, no. 1_Supplement (2018): 120.14. http://dx.doi.org/10.4049/jimmunol.200.supp.120.14.

Full text

Abstract:

Abstract B cells undergo affinity maturation to T cell-dependent antigens within specialized microenvironments in secondary lymphoid organs termed germinal centers (GCs) resulting in the selective proliferation and differentiation of high-affinity B cells. Selection is driven by the ability of antigen-specific GC B cells to extract antigen presented on follicular dendritic cells and subsequently recruit stimuli from T follicular helper cells. Successful GC B cells ultimately differentiate into plasma cells that secrete large amounts of antigen-specific antibody, or memory B cells that contribu

APA, Harvard, Vancouver, ISO, and other styles

47

Niedobitek, G., H. Herbst, LS Young, et al. "Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue." Blood 79, no. 10 (1992): 2520–26. http://dx.doi.org/10.1182/blood.v79.10.2520.2520.

Full text

Abstract:

Abstract Taking advantage of the abundant expression of the small Epstein-Barr virus (EBV)-encoded RNAs (EBERs) in latently infected cells, we have analyzed 72 normal and hyperplastic lymph nodes and three tonsils of acute infectious mononucleosis (IM) for the presence and distribution of EBV+ cells using EBER-specific in situ hybridization, in some cases combined with immunohistologic demonstration of cell type- characteristic antigens. In IM, large numbers of EBV+ lymphoid B blasts were detectable in extrafollicular areas, whereas germinal centers were generally free of EBV+ cells. In reacti

APA, Harvard, Vancouver, ISO, and other styles

48

Niedobitek, G., H. Herbst, LS Young, et al. "Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue." Blood 79, no. 10 (1992): 2520–26. http://dx.doi.org/10.1182/blood.v79.10.2520.bloodjournal79102520.

Full text

Abstract:

Taking advantage of the abundant expression of the small Epstein-Barr virus (EBV)-encoded RNAs (EBERs) in latently infected cells, we have analyzed 72 normal and hyperplastic lymph nodes and three tonsils of acute infectious mononucleosis (IM) for the presence and distribution of EBV+ cells using EBER-specific in situ hybridization, in some cases combined with immunohistologic demonstration of cell type- characteristic antigens. In IM, large numbers of EBV+ lymphoid B blasts were detectable in extrafollicular areas, whereas germinal centers were generally free of EBV+ cells. In reactive lymph

APA, Harvard, Vancouver, ISO, and other styles

49

McHeyzer-Williams, M. G., M. J. McLean, P. A. Lalor, and G. J. Nossal. "Antigen-driven B cell differentiation in vivo." Journal of Experimental Medicine 178, no. 1 (1993): 295–307. http://dx.doi.org/10.1084/jem.178.1.295.

Full text

Abstract:

The secretion of specific antibodies and the development of somatically mutated memory B cells in germinal centers are consequences of T cell-dependent challenge with the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP). Using six-parameter flow cytometry and single cell molecular analysis we can directly monitor the extent of somatic hypermutation in individual responsive (isotype switched) antigen-specific B cells. The current study provides a direct quantitative assessment of recruitment into the antibody-secreting compartment on the one hand, and the germinal center pathway to memory on the oth

APA, Harvard, Vancouver, ISO, and other styles

50

Baeza, Carlos Wong, Albany Resendiz, Carla Landa, et al. "Affinity maturation of anti-lipid IgG antibodies produced via germinal center." Journal of Immunology 198, no. 1_Supplement (2017): 74.14. http://dx.doi.org/10.4049/jimmunol.198.supp.74.14.

Full text

Abstract:

Abstract Non-bilayer phospholipid arrangements (NPA) are lipid associations different to the bilayer and are found on cell membranes; they participate in different cellular functions and are transient, but when they are stabilized by drugs such as chlorpromazine, they become immunogenic and induce the formation of anti-NPA antibodies. Mice that receive stabilized NPA share several characteristics with patients with systemic lupus erythematosus, such as the presence of anti-cardiolipin, anti-histone and anti-nuclear antibodies, lupus band, malar exanthema and glomerulonephritis. Mice with this

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!