Relevant bibliographies by topics / Geroprotector

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Geroprotector'

Author: Grafiati
Published: 4 June 2025
Last updated: 15 July 2025

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Journal articles on the topic "Geroprotector"

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Janssens, Georges E., and Riekelt H. Houtkooper. "Identification of longevity compounds with minimized probabilities of side effects." Biogerontology 21, no. 6 (2020): 709–19. http://dx.doi.org/10.1007/s10522-020-09887-7.

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Abstract It is hypothesized that treating the general aging population with compounds that slow aging, geroprotectors, could provide many benefits to society, including a reduction of age-related diseases. It is intuitive that such compounds should cause minimal side effects, since they would be distributed to otherwise healthy individuals for extended periods of time. The question therefore emerges of how we should prioritize geroprotectors discovered in model organisms for clinical testing in humans. In other words, which compounds are least likely to cause harm, while still potentially providing benefit? To systematically answer this question we queried the DrugAge database—containing hundreds of known geroprotectors—and cross-referenced this with a recently published repository of compound side effect predictions. In total, 124 geroprotectors were associated to 800 unique side effects. Geroprotectors with high risks of side effects, some even with risk for death, included lamotrigine and minocycline, while compounds with low side effect risks included spermidine and d-glucosamine. Despite their popularity as top geroprotector candidates for humans, sirolimus and metformin harbored greater risks of side effects than many other candidate geroprotectors, sirolimus being the more severe of the two. Furthermore, we found that a correlation existed between maximum lifespan extension in worms and the likelihood of causing a side effect, suggesting that extreme lifespan extension in model organisms should not necessarily be the priority when screening for novel geroprotectors. We discuss the implications of our findings for prioritizing geroprotectors, suggesting spermidine and d-glucosamine for clinical trials in humans.
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Bulterijs, Sven. "Metformin As a Geroprotector." Rejuvenation Research 14, no. 5 (2011): 469–82. http://dx.doi.org/10.1089/rej.2011.1153.

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Khavinson, V. Kh, B. I. Kuznik, S. I. Tarnovskaya, and N. S. Linkova. "GDF11 protein as a geroprotector." Biology Bulletin Reviews 6, no. 2 (2016): 141–48. http://dx.doi.org/10.1134/s207908641602002x.

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Ryzhak, A. P., B. I. Kuznik, V. N. Rutkovskaya, G. A. Ryzhak, and Yu S. Titkov. "Antiarrhythmic action of natural peptide geroprotector." Advances in Gerontology 3, no. 1 (2013): 67–69. http://dx.doi.org/10.1134/s2079057013010128.

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Anisimov, Vladimir N., Irina G. Popovich, Mark A. Zabezhinski, Sergey V. Anisimov, Georgy M. Vesnushkin, and Irina A. Vinogradova. "Melatonin as antioxidant, geroprotector and anticarcinogen." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1757, no. 5-6 (2006): 573–89. http://dx.doi.org/10.1016/j.bbabio.2006.03.012.

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Ryzhak, A. P., B. I. Kuznik, V. N. Rutkovskaya, and G. A. Ryzhak. "The antiatherosclerotic effects of a geroprotector peptide." Advances in Gerontology 2, no. 4 (2012): 332–35. http://dx.doi.org/10.1134/s2079057012040121.

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Izmailov, D. M., and L. K. Obukhova. "Melatonin as a geroprotector: Experiments withDrosophila melanogaster." Bulletin of Experimental Biology and Medicine 127, no. 2 (1999): 186–87. http://dx.doi.org/10.1007/bf02433110.

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Piskovatska, Veronika, Nadiya Stefanyshyn, Kenneth B. Storey, Alexander M. Vaiserman, and Oleh Lushchak. "Metformin as a geroprotector: experimental and clinical evidence." Biogerontology 20, no. 1 (2018): 33–48. http://dx.doi.org/10.1007/s10522-018-9773-5.

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Platonova, Elena Y., Mikhail V. Shaposhnikov, Hye-Yeon Lee, Ji-Hyeon Lee, Kyung-Jin Min, and Alexey Moskalev. "Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria." Trends in Food Science & Technology 114 (August 2021): 570–84. http://dx.doi.org/10.1016/j.tifs.2021.06.020.

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Izmaylov, Dmitry M., and Ludmila K. Obukhova. "Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster." Mechanisms of Ageing and Development 106, no. 3 (1999): 233–40. http://dx.doi.org/10.1016/s0047-6374(98)00105-5.

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Dissertations / Theses on the topic "Geroprotector"

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Байрачный, К. А., та К. Н. Наглая. "Геропротекторные эффекты рапамицина". Thesis, Сумский государственный университет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55133.

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Цель исследования: анализ литературных данных о геропротекторных свойствах рапамицина. Рапамицин был открыт как продукт обменных процессов бактерии Streptomyces hygroscopicus из образцов почвы с острова Пасхи. Препарат назван в честь туземного названия этого острова «Rapa Nui». Рапамицин представляет собой иммунодепрессантное, противогрибковое и противораковое макролидное соединение, которое действует, селективно блокируя транскрипционную активацию цитокинов, тем самым ингибируя продукцию цитокинов.
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Shemchuk, Oleksii. "Optimizing physicochemical properties of naturalantioxidants and geroprotectors: L-carnosine and melatonin." Master's thesis, 2015. http://hdl.handle.net/10400.1/7849.

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Dissertação de mestrado, Inovação Quimica e Regulamentação, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015<br>The issue of “Healthy Ageing” has become a significant challenge due to the continuous grow of World Population Ageing. Advancing health and well-being into old age and ensuring supportive environments is a main objective of NATO’s Department of Economic and Social Affairs Population Division [1]. Natural antioxidants such as L-carnosine and melatonin have been successfully used as geroprotectors. They reduce the risk of developing ageing-related diseases which is one the main aspects of healthy ageing. New formulation of the existing APIs is a widely used approach to optimize their physicochemical properties. Carnosine underwent reactions with a number of organic acids resulting in the discovery of seven new salts. The obtained salts were characterized by X-ray powder diffraction and thermal analyses. The structures were determined using X-ray Powder Diffraction (XRPD). The carnosine salts with glycolic and succinic acids might be of higher interest since both components possess antioxidant activity and carnosine, when used as a nutraceutical is usually combined with other antioxidants. Thus, the new formulation of carnosine as a salt with an acid possessing antioxidant activity can enhance its biological activity. Melatonin was co-crystallized with a number of coformers from various chemical groups. Two new co-crystals of melatonin with DABCO and piperazine were obtained by using mechanochemical technique (kneading). The structure of melatonin-DABCO co-crystal was established from a single crystal obtained by recrystallization from dichloromethane. The structure of melatonin-piperazine was solved using XRPD. Though only one of the obtained co-crystals can find a direct application in Pharmaceutical industry (DABCO does not belong to the GRAS list), our results confirm the reactivity of melatonin in co-crystallization processes, and emphasizes the need to continue the search for an improved formulation.<br>European Commission: scholarship funded within the Erasmus+ KA1 Programme, ref. 2013-0241 - Erasmus Mundus Joint Master Degree in Chemical Innovation and Regulation
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Book chapters on the topic "Geroprotector"

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Nydegger, Urs, and Thomas Lung. "Geroprotector." In Senescence Back and Forth. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-32276-1_10.

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Kaur, Gurcharan, Taranjeet Kaur, Anuradha Sharma, et al. "Intermittent Fasting-Dietary Restriction as a Geroprotector." In Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1699-9_13.

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Lushchak, Oleh, Veronika Piskovatska, Olha Strilbytska, et al. "Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-55035-6_11.

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Skulachev, Vladimir P., Alexander V. Bogachev, and Felix O. Kasparinsky. "Possible Medical Applications of Membrane Bioenergetics: Mitochondria-Targeted Antioxidants as Geroprotectors." In Principles of Bioenergetics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33430-6_16.

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Dmytriv, Tetiana R., and Volodymyr I. Lushchak. "Isothiocyanates from cruciferous plants as geroprotectors." In Advances in Pharmacology. Elsevier, 2025. https://doi.org/10.1016/bs.apha.2025.01.023.

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Shintani, Tomoya, Laura Lema-Perez, and Hideya Shintani. "The Sugars with the Potential to Prolong Human Life." In Sugar Intake - Risks and Benefits and the Global Diabetes Epidemic. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97885.

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Sugar is the main source of energy for all cells in the human body. On the other hand, cells can also obtain energy from fats and proteins depending on conditions, although this metabolic process is more difficult and less common in cells. Sugar intake has increased in recent decades and is included in most of our dietary products. However, many studies indicate that sugar intake increases the prevalence of suffering from various harmful health conditions such as obesity. As a consequence, obesity is related to several chronic diseases such as hypertension, insulin resistance, and diabetes mellitus in humans. This is due to an excessive intake of sugars and sedentary lifestyles, causing a deterioration in the organs of our body, and consequently, reducing life expectancy. In this chapter, sugars that both shorten and lengthen life expectancy are presented. The latter are recent options that have emerged in order to continue sweetening our food in a healthier way, and would be new geroprotectors.
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Conference papers on the topic "Geroprotector"

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"Serum Polypeptide Alpha-Fetoprotein (AFP) as a possible powerful geroprotector." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-395.

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Journal articles
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