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1

Gewe, Susanne [Verfasser], and KLAUS-MICHAEL [Akademischer Betreuer] BRAUMANN. "Gesundheitsbildung im Sport an der Berufsschule : Untersuchung, Entwicklung und praxisbezogene Überprüfung eines Curriculumbausteins im Fach Sport am Beispiel von Medizinischen und Zahnmedizinischen Fachangestellten in der Ausbildung / Susanne Gewe. Betreuer: Klaus-Michael Braumann." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1046460242/34.

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2

Vasanwala, Farha Huseini. "Gene manipulations for cancer gene therapy." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/289776.

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Tumor cells can be modified with cytokine genes such as the Interleukin-2 (IL-2) gene. The levels of IL-2 expressed are critical for successful treatment. We have tried to achieve higher levels of IL-2 than those currently available by conventional plasmids. Use of a transcriptional activator, e.g; the tat gene along with the HIV promoter driving the IL-2 gene, greatly increased IL-2 levels compared to widely used cytomegalovirus (CMV) driven plasmids. Control of the tat gene with an inducible promoter, i.e; the human HSP70B promoter, permitted control of gene expression. The inducibility of t
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3

Bashiardes, Evy. "Gene polymorphisms, gene expression and atherosclerotic plaques." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420882.

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4

Payne, Katie Emma. "β₃ integrin gene polymorphisms and gene regulation". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413197.

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5

Lodhi, Saad Salman Khan. "Unraveling gene gene interactions in rheumatoid arthritis." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19908.

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Rheumatoid arthritis (RA) is a systematic autoimmune disorder characterized by a persistent joint inflammation. A subset of HLA-DRB1 alleles known as shared epitope (SE) are the strongest genetic risk factors to develop anti-citrullinated protein antibody positive (ACPA-positive) RA. A strong enrichment of interactions exists between ACPA-positive RA-associated genetic variants and HLA-DRB1 SE alleles in disease development. Pathway analysis was performed to investigate how the interactions between risk variants (SNPs) with HLA-DRB1 from a previous study related to ACPA-positive RA. Gene-gene
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6

Smith, Erin N. "Gene-environment interaction in yeast gene expression /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/5025.

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7

Li, Wei. "Analyzing Gene Expression Data in Terms of Gene Sets: Gene Set Enrichment Analysis." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/math_theses/79.

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The DNA microarray biotechnology simultaneously monitors the expression of thousands of genes and aims to identify genes that are differently expressed under different conditions. From the statistical point of view, it can be restated as identify genes strongly associated with the response or covariant of interest. The Gene Set Enrichment Analysis (GSEA) method is one method which focuses the analysis at the functional related gene sets level instead of single genes. It helps biologists to interpret the DNA microarray data by their previous biological knowledge of the genes in a gene set. GSEA
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8

Carmo, Ana Paula Santos do. "Estudo da distribuiÃÃo da frequÃncia de genÃtipos de Helicobacter pylori em lesÃes gÃstricas." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9557.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A bactÃria Helicobacter pylori, à um agente etiolÃgico bem estabelecido para o desenvolvimento de lesÃes gÃstricas como gastrite, Ãlcera pÃptica, metaplasia e doenÃas malignas, com alta incidÃncia de infecÃÃo em todo mundo, porÃm cerca de 80% dos indivÃduos infectados permanecem assintomÃticos e apenas uma minoria desenvolve doenÃas a ela relacionadas. Estudos tÃm sido realizados na tentativa de identificar a relaÃÃo de genes determinantes da patogenicidade de H. pylori, entretanto, atà o momento apenas os genes cagA e o alelo de v
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9

Nastase, Mannila Maria. "Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-672-7/.

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10

Rück, Andreas. "Myocardial gene therapy and gene expression in angina pectoris /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-648-4/.

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11

Kallifidas, Dimitrios. "Horizontal gene transfer and evolution of antibiotic gene clusters." Thesis, University of Warwick, 2001. http://wrap.warwick.ac.uk/50691/.

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Genome sequencing projects from diverse bacteria and the release of genetically engineered microorganisms make the topic of horizontal gene transfer (HGT) fashionable. Sequence analysis indicates the high frequency and the importance of horizontal gene transfer to the microbial evolution. Much knowledge about horizontal transfer has been derived from studies using soil microcosms, fluorescent-marked donors and recipients and from study of the increase of the antibiotic resistance as a result of use and often abuse of antibiotics. However, little is known about the transfer of chromosomally-loc
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12

Tellier, Aurélien. "A theory of polymorphism in gene-for-gene interactions." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439932.

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13

Aouabdi, Sihem. "Gene regulation of the human pregnane-X receptor gene." Thesis, University of Surrey, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420057.

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14

Bhattacharya, Kanishka. "Gene x gene interactions in genome wide association studies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6cb7ab29-90df-4d70-bc2f-531f874b79d0.

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Genome wide association studies (GWAS) have revolutionized our approach to mapping genetic determinants of complex human diseases. However, even with success from recent studies, we have typically been able to explain only a fraction of the trait heritability. GWAS are typically analysed by testing for the marginal effects of single variants. Consequently, it has been suggested that gene-gene interactions might contribute to the missing heritability of complex diseases. GWAS incorporating interaction effects have not been routinely applied because of statistical and computational challenges re
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15

Assareh, Amin. "OPTIMIZING DECISION TREE ENSEMBLES FOR GENE-GENE INTERACTION DETECTION." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353971575.

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16

Pires, Liliana Raquel Fernandes. "Chitosan gene delivery : from intracellular trafficking to gene expression." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/2250.

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Mestrado em Engenharia Biomédica - Biomateriais<br>O quitosano é um policatião de origem natural que tem vindo a ser investigado como sistema não viral de vectorização de genes devido à sua biocompatibilidade e baixa toxicidade. No entanto, a sua baixa eficiência de transfecção tem dificultado o seu uso generalizado. Num estudo anterior mostrámos que a conjugação de resíduos de imidazol a cadeias de quitosano resulta numa melhoria da eficiência de transfecção do polímero. O principal objectivo deste estudo foi avaliar a aplicação de quitosano modificado com imidazol (CHimi) como vector para en
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17

Tessier, François. "Investigating Gene-Gene and Gene-Environment Interactions in the Association Between Overnutrition and Obesity-Related Phenotypes." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35898.

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Introduction – Animal studies suggested that NFKB1, SOCS3 and IKBKB genes could be involved in the association between overnutrition and obesity. This study aims to investigate interactions involving these genes and nutrition affecting obesity-related phenotypes. Methods – We used multifactor dimensionality reduction (MDR) and penalized logistic regression (PLR) to better detect gene/environment interactions in data from the Toronto Nutrigenomics and Health Study (n=1639) using dichotomized body mass index (BMI) and waist circumference (WC) as obesity-related phenotypes. Exposure variables in
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18

Hepp, Diego. "Influência dos genes candidatos MC1R, ASIP, TYRP1 e kit na pigmentação em ovinos crioulos e predição do efeito dos polimorfismos não sinônimos no gene MC1R humano." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119623.

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A coloração dos animais é uma característica que apresenta uma grande diversidade de fenótipos nas diferentes espécies. Diferentes abordagens podem ser utilizadas para o entendimento da diversidade na coloração existente nas espécies animais. Através da análise de genes candidatos as mutações responsáveis pela variação na coloração têm sido descritas em diferentes espécies, demonstrando o envolvimento de mecanismos moleculares variados na sua regulação. Este trabalho tem por objetivo a utilização de duas abordagens genéticas para o estudo da variação na coloração, a análise de genes candidatos
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19

Groot-Wassink, Thomas Georg. "In-vivo detection of gene expression and gene therapy for malignancy using sodium / iodide symporter gene transfection." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412885.

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20

Belcastro, Vincenzo. "Reverse engieering gene regulatory networks : Elucidation of trancriptome organization, gene function and gene regulation in mammalian systems." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534377.

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21

Sigursteinsdottir, Gudrun. "Learning gene interactions from gene expression data dynamic Bayesian networks." Thesis, University of Skövde, School of Humanities and Informatics, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-886.

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<p>Microarray experiments generate vast amounts of data that evidently reflect many aspects of the underlying biological processes. A major challenge in computational biology is to extract, from such data, significant information and knowledge about the complex interplay between genes/proteins. An analytical approach that has recently gained much interest is reverse engineering of genetic networks. This is a very challenging approach, primarily due to the dimensionality of the gene expression data (many genes, few time points) and the potentially low information content of the data. Bayesian n
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22

Petronella, Nicholas. "Gene Conversions and Selection in the Gene Families of Primates." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20538.

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We used the GENECONV program, the Hsu et al. (2010) method and phylogenetic analyses to analyze the gene conversions which occurred in the growth hormone, folate receptor and trypsin gene families of six primate species. Significant positive correlations were found between sequence similarity and conversion length in all but the trypsin gene family. Converted regions, when compared to non-converted ones, also displayed a significantly higher GC-content in the growth hormone and folate receptor gene families. Finally, all detected gene conversions were found to be less frequent in conserved gen
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23

Payne, Richard. "Gene discovery in Catharanthus roseus using virus induced gene silencing." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59379/.

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This thesis presents the use of Virus Induced Gene Silencing (VIGS) for the discovery of enzymes and transporters involved in monoterpene indole alkaloid (MIA) metabolism in the medicinal plant Catharanthus roseus. C. roseus is the source of a number of MIAs that are used as chemotherapeutic agents in the treatment of a variety of cancers, however the complete biosynthetic pathway for these metabolites remains to be elucidated. Additionally, this metabolic pathway is subcellulary compartmented with the key branch point enzyme, strictosidine synthase, localised to the plant vacuole. There is th
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24

Ashbourne, Excoffon Katherine J. D. "Adenoviral-mediated gene transfer of the human lipoprotein lipase gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0013/NQ56498.pdf.

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25

Ge, Rongbin. "Development of nonviral gene delivery and of anti-gene reagents /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-326-9/.

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26

Grant, A. "The hippocalcin gene : a study in neuron-specific gene expression." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599607.

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The regulation of gene expression in differentiated neurons is poorly understood. By studying the transcriptional regulation of particular "model genes", whose expression is neuron specific, we hope to gain insight into the mechanisms governing neuron specific gene expression as a whole. The rat hippocalcin gene encodes a small calcium binding protein. Northern blot analysis and an in-situ hybridization study demonstrated that rat hippocalcin gene expression is brain specific, with different neuronal populations transcribing the gene to varying extents. Particularly high hippocalcin mRNA level
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27

Shaw, Paul Andrew. "Improving gene delivery for gene therapy and DNA vaccination applications." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614094.

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28

Hsia, Kan-Tai. "Use of gene targeting to study the mouse ERCC1 gene." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/14118.

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The main aims of this work to set up two new mouse models, by conventional and conditional gene targeting, to investigate the functions of ERCC1, which has not, thus far, been associated with any known human disorders. To facilitate gene targeting studies, a series of overlapping ERCC1 genomic clones were retrieved from a bacteriophage library. Analysis of the mouse ERCC1 5'-flanking region revealed a novel transcription initiation site. Furthermore, several potential liver- and brain-specific transcription factor binding sites were present. A novel ERCC1-deficient mouse line, designated ET#20
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29

McGinley, Susan. "Tracking Corn Gene Regulation: Learning More About Basic Gene Mechanisms." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2000. http://hdl.handle.net/10150/622270.

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30

Yeğin, Zeynep Arslanoğlu Alper. "Hiv-1 regulatory gene dependent expression of a toxic gene/." [s.l.]: [s.n.], 2006. http://library.iyte.edu.tr/tezlerengelli/master/biyoloji/T000556.pdf.

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31

Saracel, Nüket. "Gece çalışması ve Türk iş hukukunda gece çalışmasının düzenlenme esasları." Eskişehir [Turkey] : Anadolu Üniversitesi Basımevi, 1987. http://catalog.hathitrust.org/api/volumes/oclc/26856217.html.

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32

Wisecaver, Jennifer Hughes. "Horizontal Gene Transfer and Plastid Endosymbiosis in Dinoflagellate Gene Innovation." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/265594.

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Recent studies suggest that horizontal gene transfer (HGT) plays an important role in niche adaptation in some eukaryotes and may be a major evolutionary force in unicellular lineages. One subcategory of HGT is endosymbiotic gene transfer (EGT), which is characterized by a large influx of genes from endosymbiont to host nuclear genome and is a critical step in the establishment of permanent organelles, such as plastids. The dinoflagellates are a diverse group of mostly marine eukaryotes that have a propensity for both HGT and plastid endosymbiosis. Many dinoflagellates are predators and can ac
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33

Wang, Rui Ning. "Epitaxial growth and characterization of GeTe and GeTe/Sb2Te3 superlattices." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18135.

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Die epitaktische Wachstum von GeTe Dünnschichten und Sb2Te3/GeTe Übergittern durch Molekularstrahlepitaxie wird auf drei verschiedenen Silizium Oberflächen gezeigt: Si(111)−(7×7), Si(111)−(√3×√3)R30°−Sb, und Si(111)−(1×1)−H. Mit Röntgenstrukturanalyse wird bewiesen, dass die epitaktische Beziehung der GeTe Schicht von der Oberflächepassievierung abhängig ist; auf einer passivierten Fläche können verdrehte Domänen unterdrückt sein. Dieses Verhalten ähnelt dem, welches bei 2D Materialien zu erwarten wäre, und wird auf die Schwäche der Resonanten ungebundenen Zustände zurückgeführt, die durch Pei
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34

Oliveira, Thiago Yukio Kikuchi. "Aspectos moleculares da evolução do gene DARC em primatas." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-06042009-111417/.

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Genes envolvidos com a interação hospedeiro-patógeno são fortemente afetados pela seleção natural positiva. O gene codificante do antígeno sangüíneo Duffy, também conhecido como DARC (Duffy Antigen Receptor for Chemokines), tem um importante papel na invasão dos eritrócitos pelos parasitas causadores da malária, Plasmodium vivax em humanos e Plasmodium knowlesi em outros primatas. A estrutura do gene DARC já é conhecida, estando este presente na região 1q22q23 do cromossomo 1, e sendo composto por dois éxons separados por um grande íntron. Em uma população africana a deleção de um nucleotídeo
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35

BOUSSADIA, OREDA. "Deletion du promoteur du gene unr murin par recombinaison homologue : etude de l'interference transcriptionnelle dans le locus unr / n-ras et du role biologique de la proteine unr." Paris 11, 1996. http://www.theses.fr/1996PA11T017.

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36

Rees, Helen C. "Environmental gene screening." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/29836.

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DNA was directly extracted from a number of water and sediment samples taken from the soda lakes of the Kenyan-Tanzanian Rift Valley. A limited number of microbial specific enrichments of these were also extracted in the same way. 16S rDNA genes were amplified by the polymerase chain reaction (PCR) and microbial diversity studied using denaturing gradient gel electrophoresis (DGGE) and terminal restriction fragment length polymorphism (t-RFLP). DGGE had relatively poor resolution, as shown by the limited number of bands on gels as compared to the minimal number of amplicons represented by t-RF
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37

Sumun, Faizal. "Chemiluminescent gene probes." Thesis, University of Sussex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352945.

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Kong, David Sun 1979. "Microfluidic gene synthesis." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45755.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2008.<br>"June 2008."<br>Includes bibliographical references.<br>The ability to synthesize custom de novo DNA constructs rapidly, accurately, and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications in both traditional molecular biology and the emerging field of synthetic biology, from the synthesis of large sets of novel proteins to the complete re-writing of bacterial genomes. Ho
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39

Preuten, Tobias. "Organellar gene expression." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16142.

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Zusätzlich zu der eubakteriellen RNA-Polymerase (RNAP) der Plastiden sind im Zellkern von Arabidopsis thaliana drei weitere, phagentypische RNAP kodiert, die jeweils aus nur einer Einheit aufgebaut sind. Die Enzyme RpoTp und RpoTm werden in die Plastiden, bzw. die Mitochondrien transportiert, während RpoTmp in beiden Organellen zu finden ist. Um die Lichtabhängigkeit der RpoT-Gene zu untersuchen, wurde die lichtinduzierte Akkumulation ihrer Transkripte in 7-Tage alten Keimlingen, sowie 3- bzw. 9-Wochen alten Rosettenblättern mittels quantitativer real-time PCR ermittelt. Die entwicklungsabhäng
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Prochnow, Blair Raymond. "Analyzing gene function in the mouse gene trap mutations in Arp3, Lsm16, and a novel KRAB-ZF gene /." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983475202.

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Calais, Flávia Leme 1983. "Estudo dos genes SRD5A2 e 17BHSD3 em casos de ambiguidade genital em pacientes com cariótipo 46,XY." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317125.

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Orientador: Maricilda Palandi de Mello<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-17T10:04:15Z (GMT). No. of bitstreams: 1 Calais_FlaviaLeme_M.pdf: 2545885 bytes, checksum: 01651078ede5d0d74599fe9cf524b8bd (MD5) Previous issue date: 2010<br>Resumo: Para um correto desenvolvimento sexual masculino em humanos, é necessária a presença, entre outros, de dois hormônios esteróides: a testosterona (T) e a diidrotestosterona (DHT). A T é o hormônio responsável pelo desenvolvimento da genitália interna masculina, já a DH
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Gubert, Gabriela Farias. "Clonagem e expressão das enzimas heterólogas xilose redutase e xilitol desidrogenase em Saccharomyces cerevisiae e análise do consumo de xilose por linhagens recombinantes." Florianópolis, SC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/177540.

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TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.<br>Submitted by Gabriela Farias Gubert null (gabriela.gubert@grad.ufsc.br) on 2017-07-14T14:00:05Z No. of bitstreams: 1 Gabriela Farias Gubert.pdf: 903100 bytes, checksum: 8ad4192c07dd690dabcaa005dbeea52b (MD5)<br>Approved for entry into archive by Philipi Schneider (p.schneider@ufsc.br) on 2017-07-14T14:15:24Z (GMT) No. of bitstreams: 1 Gabriela Farias Gubert.pdf: 903100 bytes, checksum: 8ad4192c07dd690dabcaa005dbeea52b (MD5)<br>Made available in DSpace on 2017-07-14T14:15:24Z (GMT). No. of bitst
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Bellot, Pujalte Pau. "Study of gene regulatory networks inference methods from gene expression data." Doctoral thesis, Universitat Politècnica de Catalunya, 2017. http://hdl.handle.net/10803/406095.

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A cell is a the basic structural and functional unit of every living thing, it is protein-based an that regulates itself. The cell eats to stay alive, it grows and develops; reacting to the environment, while subjected to evolution. It also makes copies of itself. These processes are governed by chain of chemical reactions, creating a complex system. The scientific community has proposed to model the whole process with Gene Regulatory Networks (GRN). The understanding of these networks allows gaining a systems-level acknowledgment of biological organisms and also to genetically related disease
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44

Saminadin-Peter, Sarah S. "Evolution of gene expression and gene-regulatory sequences in Drosophila melanogaster." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-94446.

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Thanaketpaisarn, Oranuch. "Optimization of nonviral gene delivery system for in vivo gene therapy." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/144625.

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46

Abedi, Vida. "System-identification of gene regulatory networks by systematic gene perturbation analysis." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28254.

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Systems biology is an interdisciplinary field that combines engineering and molecular biology to better understand the 'design principles' of biological systems. One of the main goals in systems biology is to understand and map complex biological networks. In order to achieve this goal, tools able to process the non-linearity and high dimensionality of biological systems are urgently needed. To develop, test and benchmark tools for investigation of biological processes, it is important to utilize a model system that is able to provide a glimpse of complexity found in higher organisms, and be s
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Walsh, Vanessa. "Investigation of the function of the SA gene by gene targeting." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29368.

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The SA gene encodes a 578 amino acid protein of unknown function. SA was first identified as a candidate gene for hypertension and blood pressure regulation due to its increased expression in the kidneys of genetically hypertensive compared with normotensive rats. The aim of the work undertaken in this thesis was to investigate the function of the SA gene by gene targeting in the mouse and to assess any possible involvement of the SA protein in BP homeostasis. We utilised ES cell technology to generate a mouse model carrying a null mutation of the SA gene. Mice lacking the protein product of t
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48

Menassa, Rima. "Nuclear-mitochondrial gene interactions and mitochondrial gene expression in Brassica napus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0018/NQ44513.pdf.

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49

Bakaric, Robert [Verfasser]. "Genomics of Gene Gain and Gene Loss in Eukaryotes / Robert Bakaric." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1122438567/34.

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Wang, Wen-Hua 1965. "Cytokine gene expression and gene therapy in experimental corneal graft rejection." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38529.

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Abstract:
It has been proposed that CD4+ T cells and cell-mediated immunity play a central role in corneal allograft rejection. Two subsets of CD4+ T cells, Th1 and Th2 cells, are known to cross-regulate each other through their cytokine pattern and the immune response might be directed predominantly in one or the other direction. As such, it has been hypothesized here that predominant Th1 type immune response could lead to corneal allograft rejection, and that previous inflamed corneal beds (high-risk eyes) might augment the Th1 response and thus accelerate the graft rejection.<br>Reverse transcription
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