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Dissertations / Theses on the topic 'GFAP/Gfap'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wen, Shu-Fang. "The role of GFAP mutation in Alexander disease." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2064/.

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Alexaneder disease (AxD) is a primary genetic disorder of astrocyte caused by mutations in the type 111 intermediate filament (IF) glial fibrillary acidic protein (GFAP). The pathological hallmark of this disease is the presence of Rosenthal fibres (RF), ubiquitinated protein aggregates with GFAP being the primary constituent. On the basis of age at onset, the disease has been divided into three subtypes: infantile, juvenile and adult. Whilst one of the common mutations R416W is reported in AxD with a wide range in disease severity and age of onset, the mechanisms by which this mutation leads

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2

Gumprecht, Annett. "Analyse morphometrischer Messungen an Astrozyten des Hippokampus von Wildtypmäusen im Vergleich zu GFAP-/- - Vimentin-/- - Mäusen." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-129946.

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Die Forschungsergebnisse der letzten Jahre beweisen, dass die Informationsverarbeitung im ZNS auf eine ausgewogene Interaktion zwischen den Neuronen und den Astrozyten im Sinne eines funktionellen Netzwerkes angewiesen ist. Allerdings liegen nur unzureichende Erkenntnisse über den strukturellen Charakter dieser symbiotischen Beziehung vor. Zu den grundlegenden Aufgaben der Astrozyten gehört die Modulation der synaptischen Aktivität von Neuronen, Aufrechterhaltung der extrazellulären Homoöstase, Ausbildung der Blut-Hirn-Schranke, Pufferung der lokalen Kaliumkonzentration und die Synthese von Zy

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3

Tackenberg, Mark. "Quantitative Aspekte der Astrozyten von Wildtyp- und GFAP-/- VIM-/- Labormäusen." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-69157.

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Astrozyten erfüllen unverzichtbare Aufgaben im ZNS. Sie sorgen im Normalfall unter anderem für eine ausgewogene K+/H2O-Clearence, regulieren den Gefäßdurchmesser, bilden die Blut-/Hirnschranke, betreiben “Transmitter-Recycling” und modulieren die interneuronale Signalweitergabe durch prä- und postsynaptische Mechanismen. Die Funktionen und Einflüsse dieser zentralnervösen Gliazellen unter pathologischen Bedingungen im ZNS sind bei weitem nicht so gut untersucht, aber ebenso vielfältig. Eine ganz entscheidende Frage stellt sowohl unter physiologischen wie auch pathologischen Bedingungen das Vor

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4

Magerkurth, Olaf. "Nachweis von saurem glialen Faserprotein (GFAP) in humanem Serum und erste klinische Ergebnisse." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-16561.

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5

Cardoso, Marie-Céleste. "Implication du gène GFAP dans les pathologies humaines neurodégénératives de la substance blanche." Clermont-Ferrand 1, 2008. http://www.theses.fr/2008CLF1MM22.

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Parmi les maladies génétiques affectant la substance blanche du système nerveux ou leucodystrophies, la maladie d'Alexander est caractérisée par une accumulation diffuse dans les astrocytes d'inclusions cytoplasmiques éosinophiles, les fibres de Rosenthal, accompagnée d'une démyélinisation. Il est clairement établi que le spectre clinique et les caractéristiques radiologiques de cette pathologie sont plus vastes que décrit initialement pour les formes précoces, les formes adultes étant particulièrement hétérogènes. Nous avons développé une méthode diagnostique, rapide et peu onéreuse, basée su

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6

SUGIHARA, YASUO, MINORU UEDA, HIDEYUKI NAKASHIMA, et al. "INVOLVEMENT OF GLIAL ACTIVATION IN TRIGEMINAL GANGLION IN A RAT MODEL OF LOWER GINGIVAL CANCER PAIN." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20551.

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7

Higgins, Michael Anthony. "Morphological and Immunocytochemical Investigation of Canine Oligodendrogliomas." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/45210.

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Previous studies of human oligodendroglial neoplasms have demonstrated the diagnostic and prognostic values of histomorphologic features and immunocytochemical markers. Primary spontaneous canine intracranial tumors share many of the biologic behaviors and pathologic features of their human counterparts. The objectives of this study were to determine if associations existed between five histomorphologic features (mitoses, cellular atypia, necrosis, vascular hypertrophy, and vascular proliferation), and three immunocytochemical markers (GFAP, EGFR, and Ki-67 labeling index) and the degree of

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8

Steinriede, Anja. "Eingrenzung der Leichenliegezeit mittels immunhistochemischer Untersuchung des Glial-fibrillary-acidic-Protein (GFAP) in Astrocyten." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975443879.

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9

Bush, T. G. "Ablation of astrocytes in transgenic mice expressing HSV-thymidine kinase from the mouse GFAP promoter." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597152.

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To investigate further the functions of astrocytes, a transgenic mouse was generated in which astrocytes can be ablated selectivity. Expression of herpes thymidine kinase (HSV-tk) was targeted to astrocyte using the GFAP promoter. HSV-tk can metabolise anti-herpetic agents, such as ganciclovir (GCV), which results in the formation of toxic moieties that induce cell death. The GFAP promoter cassette was obtained from Lennart Mucke of the Scripps Institute (now UCSF) into which the HSV-tk coding sequence was inserted. A linearised GFAP-HSV-<I>tk </I>construct was microinjected into fertilised mo

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10

Crawford, Jessica D., Michelle J. Chandley, Katalin Szebeni, Attila Szebeni, Brandon Waters, and Gregory A. Ordway. "Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder." Digital Commons @ East Tennessee State University, 2015. https://doi.org/10.1002/aur.1480.

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Based on evidence of abnormalities in axon thickness and neuronal disorganization, autism spectrum disorder (ASD) is commonly considered to be a condition resulting from neuronal dysfunction. Yet, recent findings suggest that non-neuronal cell types also contribute to ASD pathology. To investigate the role of glial cells in ASD, a combination of protein and gene expression analyses were used to determine levels of two glial markers, glial fibrillary acidic protein (GFAP) and myelin oligodendrocyte glycoprotein (MOG), in the postmortem brain tissue from control and ASD donors. Levels of GFAP im

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11

Abuawad, Mohammad. "Pathological changes in Alexander disease : a comparative study in human and mice with GFAP mutations." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC296.

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La maladie d'Alexander est une maladie neurodégénérative due à des mutations hétérozygotes du gène GFAP codant le principal filament intermédiaire des astrocytes matures. Nous avons étudié l'effet des mutations GFAP dans l'hippocampe d'un patient avec AxD infantile et de deux souris knockin, l'une portant une mutation dans le rod domain (p.R85C) et l'autre dans le tail domain (p.T409I). Chez le patient, nous décrivons pour la première fois: (i) des changements morphologiques sévères des cellules GFAP+ dans la zone subgranulaire du gyrus denté, qui ont perdu la plupart de leurs processus radiau

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12

Pimentel, Victor Camera. "ATIVIDADE DA ADENOSINA DEAMINASE EM DIFERENTES PERÍODOS APÓS A HIPÓXIA-ISQUEMIA NEONATAL EM CÓRTEX DE RATOS." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/5888.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Neonatal hypoxic-ischemic injury (HI) is the direct complication to severe choking and may cause brain damage. HI may be found in different stages and clinical manifestations contributing to neonatal morbidity and mortality. The neuropathology of neonatal HI insult is multi-factorial and complex. Hypoxic-ischemic brain damage begins during the insult and extends during the recovery period after reperfusion, thus, it is an evolutionary process. Adenosine deaminase (ADA) is an aminohidrolase actively involved in the metabolism of pur

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13

Carotti, Simone. "La fibrogenesi epatica: markers precoci e meccanismi regolatori." Doctoral thesis, La Sapienza, 2007. http://hdl.handle.net/11573/916941.

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14

GALOU, MARIA. "Expression de la gfap au cours de la gliose reactionnelle : etude a l'aide de souris transgeniques." Paris 7, 1995. http://www.theses.fr/1995PA077197.

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La regulation de l'expression du gene de la gfap a ete etudiee a l'aide de souris transgeniques. Nous avons etudie l'expression du transgene gfap-nls-lacz au cours du developpement et au cours de differentes pathologies atteignants le snc de l'animal adulte. L'expression du transgene revele des sous-populations astrocytaires qui regulent l'expression du gene de la gfap par differents elements emaillants la region promotrice. Au cours du developpement il revele la capacite du gene de la gfap a s'exprimer dans de nombreux organes embryonnaires. L'analyse de la gliose reactionnelle apres un traum

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15

Sweger, Elizabeth Joy McCarthy Ken D. "Expression of the Gi-coupled RASSL Ro1 in GFAP-positive cells a novel model of hydrocephalus /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2443.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine. On title page, i in Gi-coupled is subscript.

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16

Lycke, Christian. "Ko-Expression des astroglialen GFAP- und des oligodendrozytären PLP-Promotors in Müllerzellen der Retina: Aktivierung durch Läsionen." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-158668.

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Die Dissertation befasst sich mit der Untersuchung der Ko-Expression des GFAP- und des PLP-Promotors in Müllerzellen der Netzhaut transgener Mäuse. Die verwendete Mauslinie ist tripel-transgen für den GFAP- und den PLP-Promotor sowie für einen ROSA26-Reporter. Durch die Quantifizierung der EYFP-Expression in Müllerzellen konnte gezeigt werden, dass es nach akuter ischämischer Schädigung sowie einer angeborenen retinalen Degeneration in Müllerzellen zu einer Aktivierung des oligodendrozytären PLP-Promotors kommt. Weiterhin wurde festgestellt, dass die Aktivierung des Transkriptionsfaktors Sox-9

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17

Freitas, Rodrigo Maciel de. "Estudo da atividade glial em função do conteúdo de S100B, GFAP e glutamina sintetase em astrocitomas humanos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/11104.

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Gliomas constituem um grupo heterogêneo de tumores cerebrais. Eles podem ser divididos em duas principais categorias: astrocíticos e oligodendrogliais. Os astrocíticos, objetos deste estudo, são classificados patologicamente em quatro subtipos baseado na presença ou ausência de atipia nuclear, mitose, neovascularização e necrose. Esta classificação é útil para definir tratamento e prognóstico. A origem glial é comumente confirmada pela detecção imunoistoquímica para GFAP. Neste trabalho nós investigamos o imunoconteúdo das proteínas marcadoras astrocíticas GFAP e S100B por ELISA e a atividade

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18

Morton, Paul D. "Nuclear Factor-κB Activation in Schwann Cells Regulates Regeneration and Re-Myelination". Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/673.

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Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing post-injury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for peripheral nerve myelination. Using GFAP-IκBα-dn mice, in which NF- κB transcriptional activation is inhibited in SCs, we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and greatl

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19

Yee, Nicole. "Qualitative Assessment of Activated Microglia and Astrocytes in Focal Cortical Dysplasia: Case Series of Pediatric Patients." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623560.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Epilepsy is the most common neurologic condition seen in children. Focal cortical dysplasia (FCD), a seizure disorder characterized by abnormal cortical laminar development, comprises approximately 75% of medically intractable epilepsies in the pediatric population. A greater appreciation of the pathology and intrinsic properties of the epileptogenic zone may help in understanding why FCD lesions are drug‐resistant, and could potentia

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20

Corvetti, Luigi. "Influence of sensory experience, nerve growth factor and acetylcholine in the regulation of GFAP in the mouse visual cortex." Doctoral thesis, SISSA, 2003. http://hdl.handle.net/20.500.11767/4650.

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21

Aquino, Erika. "Downregulation of glial fibrillary acidic protein (GFAP) by TNF-α : implications for the neurogenic ability of Müller glia". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10054469/.

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Müller glial cells can regenerate the retina in zebrafish throughout life. However, in the damaged adult human retina, upregulation of inflammatory cytokines, including TNF-α, leads to Müller cell gliosis, a hallmark of which is an increase in intermediate filament glial fibrillary acid protein (GFAP) production. However, a subset of these human cells has stem cell characteristics in vitro. This study investigated the role that inflammatory cytokines may play in regulating Müller cell gliosis-associated proteins and the implications this could have on the neurogenic ability of Müller glia

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22

Silva, Mariane Castro da. "Estudo de parâmetros astrocitários (GFAP, S100B e glutamina sintetase) no hipocampo em ratos alimentados com a dieta cetogênica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/8440.

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A dieta cetogênica (DC) é uma dieta com baixos níveis de carboidratos e proteínas e altos níveis de gordura, incluída como prática médica contra desordens convulsivas, particularmente em crianças refratárias a tratamentos com drogas antiepilépticas convencionais. Contudo, a base molecular do efeito terapêutico permanece incerta. Considerando as evidências da importância das células gliais para o desenvolvimento neuronal, sobrevivência e plasticidade, investigou-se marcadores astrocitários protéicos de ratos alimentados com a DC, em diferentes regiões do hipocampo, estrutura comumente envolvida

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23

Mazumdar, Tapati. "ROLE AND REGULATION OF MYC IN GLIOBLASTOMA MULTIFORME CELL DIFFERENTIATION: IMPLICATION IN TUMOR FORMATION." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1214366273.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed Sept. 28, 2009). Advisor: Saikh Jaharul Haque. Keywords: GBM; Differentiation; Myc; Stat3; GFAP. Includes bibliographical references (p. 153-189).

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24

Lycke, Christian [Verfasser], Andreas [Akademischer Betreuer] Reichenbach, Johannes [Akademischer Betreuer] Hirrlinger, Ingo [Gutachter] Bechmann, and Frank [Gutachter] Kirchhoff. "Ko-Expression des astroglialen GFAP- und des oligodendrozytären PLP-Promotors in Müllerzellen der Retina: Aktivierung durch Läsionen : Ko-Expression des astroglialen GFAP- und desoligodendrozytären PLP-Promotors in Müllerzellen der Retina:Aktivierung durch Läsionen / Christian Lycke ; Gutachter: Ingo Bechmann, Frank Kirchhoff ; Andreas Reichenbach, Johannes Hirrlinger." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239422490/34.

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25

BOYER, SYLVIE. "Aspects genetique et moleculaire de l'expression de la proteine acide des gliofilaments (gfap) dans le cristallin de la souris." Paris 7, 1992. http://www.theses.fr/1992PA077029.

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La proteine acide des gliofilaments (gfap) a longtemps ete consideree comme un marqueur specifiquement astroglial. Cependant, depuis quelques annees, il a ete decouvert des expressions extra-neurales de la proteine, restreintes a quelques especes animales. Dans ce travail, nous nous sommes particulierement interesses a une expression de gfap dans les cellules epitheliales de cristallin de souris. Par une etude comparative, nous avons montre que les gfap cristallinienne et astrogliale sont biochimiquement semblables, qu'au cours du developpement, elles apparaissent simultanement dans les deux o

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26

Sallis, Eliza Simone Viégas. "Resposta astrocitária e oligodendroglial no tronco encefálico de ratos wistar imunossuprimidos e submetidos ao modelo desmielinizante do brometo de etídio." Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/4122.

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Brain stem remyelination following demyelination induced by ethidium bromide (EB) is carried out by oligodendrocytes and Schwann cells that invade the central nervous system when astrocytes are lost. Although oligodendrocyte remyelination is detected from 13 days onward within the lesions, the origin of the remyelinating cells is not known. To clarify oligodendrocyte origin as well as to observe astrocytic behaviour in normal (n=22) as well as immunosuppressed animals (n=22) adult Wistar rats were injected with EB in the basal cisterna. Wistar rats had an EB injection while treated with cyclop

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27

Alsén, Per. "Immunohistochemical evaluation of antibodies for staining of mouse spinal cord and mouse neuronal cells." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204738.

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28

Radomska, Katarzyna. "Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment." Doctoral thesis, Uppsala universitet, Evolution och utvecklingsbiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223332.

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The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. Uncovering the complete spectrum of QKI molecular and functional repertoire is of additional importance in light of growing evidence linking QKI dysfunction with human disease, including schizophrenia and glioma. This thesis summarizes my contribution t

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29

Catita, Joana Araújo Nobre. "Identificação de padrões de resposta das células de Müller na retinopatia degenerativa em murganho." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2012. http://hdl.handle.net/10400.5/4870.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Este trabalho teve como objectivo caracterizar as alterações retinianas observadas num modelo murino de retinopatia com degenerescência dos fotorreceptores, de forma a poder estabelecer padrões de resposta nas diferentes fases de evolução do processo degenerativo-inflamatório. Material e Métodos: Neste estudo foram utilizadas retinas de murganhos ICR adultos. Foram constituídos grupos de 4 animais. Os murganhos foram injetados intraperitonealmente com uma dose de 100 mg/Kg de iodato de sódio e eutanasiados 24, 48 e 72 horas após a

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30

Malloch, G. D. A. "The development and control of cytoskeletal GFAP assembly in the rat brain and in primary cultures of foetal rat brain cells." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332120.

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31

Tackenberg, Mark [Verfasser], Andreas [Akademischer Betreuer] Reichenbach, Ingo [Gutachter] Bechmann, and Hermann-Josef [Gutachter] Gertz. "Quantitative Aspekte der Astrozyten von Wildtyp- und GFAP-/- VIM-/- Labormäusen / Mark Tackenberg ; Gutachter: Ingo Bechmann, Hermann-Josef Gertz ; Betreuer: Andreas Reichenbach." Leipzig : Universitätsbibliothek Leipzig, 2011. http://d-nb.info/123781832X/34.

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竹村, 理明. "グリア線維性酸性タンパク質(GFAP)リン酸化の意義に関する研究". 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149548.

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Saur, Lisiani. "Efeitos do exercício físico sobre a morfofisiologia dos astrócitos imunorreativos para a Proteína Glial Fibrilar Ácida (GFAP) no hipocampo de ratos Wistar." Pontifícia Universidade Católica do Rio Grande do Sul, 2013. http://hdl.handle.net/10923/1359.

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Made available in DSpace on 2013-08-07T18:41:46Z (GMT). No. of bitstreams: 1 000447382-Texto+Completo-0.pdf: 4486344 bytes, checksum: 86fdbbba27db00743c8e29d0d264ba0e (MD5) Previous issue date: 2013<br>A wide variety of studies have demonstrated that physical activity has beneficial effects on brain function, including the improvement of cognition, the enhancement of learning and memory processes, and also displays neuroprotective effects. One of the mechanisms responsible for these beneficial effects is the influence that exercise has on brain plasticity. In this sense, the hippocampus is a

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Menet, Véronique. "Contribution de souris déficientes pour la GFAP et la Vimentine à l'étude des interactions Astrocytes-Neurones dans le cadre des lésions médullaires." Montpellier 2, 2001. http://www.theses.fr/2001MON20062.

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35

Stewart, Courtney Elizabeth. "Astrocyte Development and Function is FGF8 Signaling Dependent." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1556290142104336.

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Scruggs, Kent, Tiffany Carrasco, and Michelle Chandley. "Analysis of Neuroinflammatory Markers in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/50.

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Affecting 1 in 68 children, Autism Spectrum Disorder (ASD) is one of the most prevalent cognitive disorders in the global population. Symptoms of ASD, although typically not life-threatening, have a large impact on the social wellbeing of diagnosed individuals. Inflammation in the brain, or neuroinflammation, has previously been shown to increase the severity of the behavioral deficits associated with ASD. The exact etiology of the neuroinflammation observed in ASD remains unclear, especially in regards to protein expression that initiates the inflammatory pathway. This experiment examines

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37

Wiegmann, Tim [Verfasser], Hendrik [Gutachter] Milting, and Christos [Gutachter] Krogias. "Nutzen von GFAP und S100B als prädiktiver Biomarker für neurologische Komplikationen bei Patienten mit einem Herzunterstützungssystem / Tim Wiegmann ; Gutachter: Hendrik Milting, Christos Krogias." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1123283230/34.

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Schwab, David Emanuel [Verfasser], and Jens [Akademischer Betreuer] Schittenhelm. "Immunhistochemische Studie von Hirntumorgewebe mit spezifischen Antikörpern gegen GFAP, MAP-2, NOGO-A, OLIG-2 und WT-1 / David Emanuel Schwab ; Betreuer: Jens Schittenhelm." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1165506645/34.

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39

DAVID, JEAN-PHILIPPE. "Contribution a l'etude de la proteine glio-fibrillaire acide (gfap) et des proteines tau anormalement phosphorylees au cours du vieillissement cerebral normal et pathologique." Paris 7, 1999. http://www.theses.fr/1999PA077066.

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La maladie d'alzheimer se caracterise sur le plan morphologique par des plaques amyloides extra-cellulaires, une degenerescence neurofibrillaire intraneuronale et une gliose. Ces lesions ne sont pas qualitativement differentes de celles observees au cours du vieillissement cerebral normal. S'agit-il alors de formes infracliniques de maladie d'alzheimer ? existe-t-il un continuum entre le vieillissement cerebral normal et la maladie d'alzheimer ? ce travail a ete realise sur le cerveau de patients decedes presentant un statut cognitif normal ou a differents stades d'alteration. La quantificatio

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Thomas-Castelnau, Pierre. "Etude de l'expression des genes de la prp et de la gfap impliques dans les encephalopathies subaigues spongiformes transmissibles sous l'action de facteurs neurotropes." Paris 6, 1998. http://www.theses.fr/1998PA066716.

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Des cas de maladie de creutzfeldt-jakob sont survenus chez de jeunes patients ayant recu un traitement prolonge par hormone de croissance (gh) extractive d'origine humaine. La proteine du prion (prp) et la proteine gliofibrillaire acide (gfap) sont 2 proteines de l'hote qui s'accumulent fortement dans le systeme nerveux central (snc) des sujets atteints d'encephalopathies subaigues spongiformes transmissibles (esst). L'expression anormale de leur genes pourrait en theorie contribuer aux mecanismes physiopathologiques de la neurodegenerescence observee. Dans un premier temps, nous avons etudie

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Mignot, Cyril. "Etudes des mécanismes pathologiques en cause dans l'agrégation de la GFAP mutée dans la maladie d'Alexander, une atteinte primaire de l'astrocyte aboutissant à une leucodystrophie." Paris 6, 2007. http://www.theses.fr/2007PA066477.

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La maladie d’Alexander est une maladie neurodégénérative due à des mutations hétérozygotes dans la GFAP, filament intermédiaire majoritaire de l’astrocyte mature, conduisant à la formation d’agrégats La conséquence des mutations de la GFAP sur la formation du cytosquelette astrocytaire, la façon dont les agrégats se forment et l’induction potentielle de processus de défense cellulaires restent à déterminer. Nous avons étudié différentes mutations de la GFAP dans des astrocytes murins sauvages ou dépourvus de GFAP et/ou de vimentine et dans des cellules SW13. Dans les astrocytes, la GFAP mutée

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von, Geymüller Teresa. "Einfluss einer autologen Knochenmarkzelltherapie auf reaktive Astrogliose und Glukosetransporter-1-Expression in grauer und weißer Substanz des Großhirns nach fokaler zerebraler Ischämie beim Schaf." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-98722.

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Ziele der hier vorliegenden Arbeit waren eine immunhistochemische Analyse von GFAP (‚glial fibrillary acidic protein’) und GLUT-1 (Glukosetransporter-1) nach fokaler zerebraler Ischämie sowie deren mögliche Beeinflussung durch eine intravenöse Transplantation autologer mononukleärer Knochenmarkzellen (mKMZ) im Schafmodell. Eine differenzierte Analyse der Zielstrukturen in grauer und weißer Substanz (GS bzw. WS) sollte Aufschluss über eventuell unterschiedliche Reaktionsmuster liefern. Das Gehirnmaterial von zehn Tieren der bereits 2006/2007 stattgefundenen Studie, welche mit PET und MRT-Unters

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Oppelt, Daniela Mendes. "Papel das reservas intracelulares de cálcio no efeito de aminoácidos excitatórios sobre a fosforilação da proteína ácida fibrilar glial (GFAP) em hipocampo de ratos jovens." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2002. http://hdl.handle.net/10183/1868.

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A proteína ácida fibrilar glial (GFAP) é uma proteína da classe dos filamentos intermediários, exclusivamente expressa em astrócitos no sistema nervoso central (SNC). A função específica da fosforilação desta proteína é ainda desconhecida. No entanto, tem sido demonstrado que o equilíbrio dinâmico entre o estado fosforilado e desfosforilado de sítios específicos da GFAP pode regular a polimerização e despolimerização dos filamentos intermediários durante eventos de estruturação do citoesqueleto glial. Nosso grupo de pesquisa demonstrou que a fosforilação da GFAP em hipocampo de ratos jovens (P

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Karkow, Ana Raquel Menezes. "Efeitos da estimulação neonatal sobre a expressão das proteínas S100B e GFAP no locus coeruleus, córtex frontal e bulbo olfatório de ratos machos e fêmeas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/13225.

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A estimulação neonatal ocasiona alterações no desenvolvimento neuroendócrino, morfológico e comportamental de ratos. O procedimento de manipulação neonatal promove uma ruptura na relação mãe-filhote que pode perturbar o desenvolvimento do SNC. Uma das alterações morfológicas apresentadas em ratos machos e fêmeas manipulados no período neonatal é a diminuição do número de neurônios no locus coeruleus. A S100B é uma proteína ligante de cálcio secretada por astrócitos que pode apresentar ações extracelulares neurotróficos e neurotóxicas. Diversos estudos relacionam alterações dos níveis de S100B

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Piton, Valérie. "Induction combinée des gènes c-fos, hsp 70 et activation du gène gfap au cours de crises épileptiques provoquées par le soman, un neurotoxique organophosphore." Montpellier 1, 1997. http://www.theses.fr/1997MON1T012.

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Gumprecht, Annett [Verfasser], Andreas [Akademischer Betreuer] Reichenbach, Ingo [Gutachter] Bechmann, and Antje [Gutachter] Grosche. "Analyse morphometrischer Messungen an Astrozyten des Hippokampus von Wildtypmäusen im Vergleich zu GFAP-/- - Vimentin-/- - Mäusen / Annett Gumprecht ; Gutachter: Ingo Bechmann, Antje Grosche ; Betreuer: Andreas Reichenbach." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238527930/34.

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Lupien, Caroline. "Mise au point d'une méthode de culture des cellules de Müller de rétines humaines et régulation transcriptionnelle du gène de la GFAP dans ces cellules." Thèse, Université du Québec à Trois-Rivières, 2000. http://depot-e.uqtr.ca/3083/1/000672727.pdf.

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Sdzuj, Martin [Verfasser]. "Reevaluierung der klinischen und labordiagnostischen Kriterien zur Differenzierung von viralen Meningitiden und bakteriellen Meningitiden, Meningoencephalitiden und Verwendung der GFAP-Messung als alternatives diagnostisches Verfahren / Martin Sdzuj." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1034124501/34.

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Saur, Lisiani. "Efeitos do exerc?cio f?sico sobre a morfofisiologia dos astr?citos imunorreativos para a Prote?na Glial Fibrilar ?cida (GFAP) no hipocampo de ratos Wistar." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2013. http://tede2.pucrs.br/tede2/handle/tede/5455.

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Made available in DSpace on 2015-04-14T14:51:23Z (GMT). No. of bitstreams: 1 447382.pdf: 4486344 bytes, checksum: 86fdbbba27db00743c8e29d0d264ba0e (MD5) Previous issue date: 2013-03-06<br>A wide variety of studies have demonstrated that physical activity has beneficial effects on brain function, including the improvement of cognition, the enhancement of learning and memory processes, and also displays neuroprotective effects. One of the mechanisms responsible for these beneficial effects is the influence that exercise has on brain plasticity. In this sense, the hippocampus is a brain region

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Garcez, Ricardo Castilho. "Adesão, proliferação e migração de células de astrocitoma humano U-87 em fibronectina, laminina e colágeno IV e a expressão e organização de vimentina e GFAP." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/88035.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências<br>Made available in DSpace on 2012-10-22T04:59:25Z (GMT). No. of bitstreams: 1 226277.pdf: 2569024 bytes, checksum: 6e94ffdc7c0ece32ed5bc18dbb06b81b (MD5)<br>O microambiente extracelular é capaz de modular a organização e expressão dos filamentos intermediários (vimentina, GFAP) durante os processos de adesão, proliferação, migração e diferenciação celular. A elucidação destes mecanismos é de relevante importância no estudo da biologia de células normais e

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