To see the other types of publications on this topic, follow the link: GFR.
Dissertations / Theses on the topic 'GFR'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'GFR.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Koryčanský, Roman. "Ventilace tlakové obálky reaktoru GFR." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231459.
Full textAbstract:
This paper describes the design of the ventilation pressure cover of the demonstrator GFR. The first part is a brief research project GFR and the effects of temperature on the inside structures. In the following part is calculated balance heat losses within the pressure cover for three cases: non-insulated, fully-insulated and partially insulated surface of the reactor. The following is a design of a heat sink for partially insulated surface.
2
Mlčúch, Adam. "Opatření pro zmírnění následků těžké havárie reaktoru GFR." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231460.
Full textAbstract:
This thesis deals with the severe accident of the gas-cooled fast reactor GFR. At the beginning of the study there is a review of the gas-cooled fast reactor subject. Next part is focused on description of possible solutions for severe accidents with emphasis on the solution applied in the Generation III+ reactors. Chapters that deal with material and thermal balance with severe accident of GFR demonstration unit, along with the chapter which analyses features of the corium, create a basis for the conceptual design of core catcher of GFR demonstration unit, which forms the final part of this thesis.
3
Eivensitz, Ran. "A QUANTITATIVE ANALYSIS OF PATIENTS WITH POSSIBLE AUGMENTED RENAL CLEARANCE AND ITS RELEVANCE TO PREDOMINANTLY RENALLY EXCRETED DRUGS." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_233713-04964.
Full textAbstract:
Objective of work: the aim of this study was to conduct a retrospective, quantitative, descriptive survey accompanied with a comparative statistical research, in which cases of patients with augmented renal clearance were examined and analyzed regarding the similarities and differences between them and their relevance for possible under-dosage of predominantly renally excreted drugs. Tasks: 1. to detect all cases of lower than 50 µmol/L Scr measurements and calculate possible ARC using Cockcroft-Gault equation in a defined period of time in a Lithuanian hospital in Kaunas. 2. To compare the performance of 3 different equations to distinguish the ARC as assessed by Cockcroft-Gault equation from non-ARC cases. 3. To analyze possible reasons associated with these ARC cases. 4. To search for the cases when predominantly renally excreted drugs were prescribed to these patients.<br>Tikslas darbo: Šio tyrimo tikslas buvo atlikti a posteriori, kiekybinį aprašomąjį tyrimą Kartu su lyginamosios statistinių tyrimų, kuriais atvejais pacientai, sergantys inkstų papildyta klirensas buvo išnagrinėti ir išanalizuoti apie panašumus ir skirtumus tarp jų ir jų svarbą galimo nepakankamo dozę daugiausia išsiskiria pro inkstus narkotikų. Uždaviniai: 1. Aptikti bet mažesnis negu 50 mmol / l SCR matavimų bylas ir apskaičiuoti galimą ARC naudojant Kokrofto-Gault lygtis nustatytą laiką, Lietuvos ligoninę Kaune. 2. Norėdami palyginti iš 3 skirtingų lygčių atskirti ARC, įvertintas Kokrofto-Gault lygtį kokybės iš ne ARC atvejais. 3. Išanalizuoti galimas priežastis, susijusias su šių ARC atvejais. 4. Norėdami ieškoti atvejai, kai daugiausia išsiskiria pro inkstus narkotikų buvo nustatyta, kad šiems pacientams.
4
Burniston, Maria Teresa. "Accuracy and value of measurement of GFR in oncology patients." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521445.
Full text
5
Laho, Tomas, John D. Clarke, Anika L. Dzierlenga, et al. "Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir." PERGAMON-ELSEVIER SCIENCE LTD, 2016. http://hdl.handle.net/10150/621211.
Full textAbstract:
Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on renal transport processes has yet to be fully understood. The goal of this study was to determine the effect of nonalcoholic steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine and choline deficient diet to induce nonalcoholic steatohepatitis.
6
Gonda, Kathleen A. "Evaluation of Iohexol Clearance to Estimate Glomerular Filtration Rate in Normal Horse Foals." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/31934.
Full textAbstract:
Estimation of the glomerular filtration rate (GFR), accepted as one of the earliest and most sensitive indicators of renal dysfunction, can be determined in horses using standard techniques
In adult horses and foals, renal dysfunction can occur as a secondary complication to gastrointestinal disorders, dehydration, septicemia, endotoxemia and nephrotoxic drug administration. Measurement of renal function is an important feature not only in the diagnosis, but also in the prognosis and management of renal disease. Commonly used drugs such as phenylbutazone and gentamicin can be highly nephrotoxic under certain conditions. Of particular concern are those drugs, including the aminoglycoside antibiotics, that are eliminated almost exclusively by the kidney. Knowledge of a patients renal status prior to treatment would direct efforts at; 1) restoring kidney function prior to protracted therapy with potentially damaging drugs, 2) adjusting the dose of a life-saving drug based on the magnitude of dysfunction, or 3) selecting a drug that is not dependant on renal function for elimination. such as endogenous or exogenous renal creatinine clearance. Unfortunately, these techniques can be time consuming, dangerous to perform on fractious patients, require trained personnel and are subject to errors most often associated with improper or incomplete urine collection. Recently, tests using iohexol, a radiographic contrast agent, have been developed to estimate the GFR in human beings, dogs and cats with results that have been validated by traditional standards. Most testing protocols require a single bolus injection of iohexol, followed by 2 or 3 blood samples obtained over a few hours. Compared to traditional testing methods, samples are easily and rapidly obtained making the testing procedure less stressful for the patient. A simple method to measure GFR in horses that does not require urine collection, would allow veterinarians in a clinical setting the ability to determine a patientâ s renal status easily and safely.
The objectives of this study were; 1) model the pharmacokinetic profile of iohexol in horse foals, 2) compare creatinine clearance, an accepted standard for GFR determination in patients, with iohexol clearance, and 3) develop sampling parameters and calculation methods for a practical test, based on iohexol clearance, that compares favorably with creatinine clearance in horse foals.
Iohexol concentration time data were best described using a 3-compartment open model. Mean creatinine clearance (2.17 ml/min/kg) and mean iohexol clearance (2.15 ml/min/kg) showed good agreement. In addition, GFR values for all foals using either method were within published reference ranges for this species. The results of this study indicate that a single intravenous injection of iohexol at a dose of 150 mg/kg, followed by collection of 2 serum samples at 4 and 6 hours post injection can be used to estimate the GFR in healthy horse foals. Mean corrected GFR value (CLpredicted) for 10 foals in this study was 2.15 ml/min/kg.<br>Master of Science
7
Kilbride, Hannah Speranza. "Estimating GFR and the effects of AKI on progression of chronic kidney disease." Thesis, University of Kent, 2015. https://kar.kent.ac.uk/53613/.
Full textAbstract:
Chronic kidney disease (CKD) is a common health problem with a high prevalence in the elderly and is associated with high mortality rates and co-morbidity. CKD guidelines recommend that diagnosis and staging of CKD be based on estimated glomerular filtration rate (eGFR). Estimating GFR requires estimating equations using the variables gender, race and age and body surface area based on serum creatinine levels. The commonly recommended and used equations are the Modification of Diet in Renal Disease (MDRD) study and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations but these have not yet been validated in elderly people, who are at significant risk of developing CKD. The numbers of patients with progressive CKD is reportedly low with only a small proportion of patients reaching end-stage renal disease (ESRD). This study set out to find out why there is such a disproportion in the high prevalence of CKD and the low incidence of ESRD patients. Many patients die before they reach ESRD but prevalence studies have shown that mortality rates alone do not account for these numbers. I hypothesised that the methods used to estimate GFR underestimate renal function in elderly people causing an overestimate in CKD prevalence. This study firstly set out to assess the accuracy of the MDRD and CKD-EPI equations in an elderly Caucasian population against measured GFR across a wide range of renal function. The study demonstrated both equations perform fairly accurately in the elderly population with a tendency to slightly over-estimate GFR. This study has validated the use of these estimating equations in an elderly Caucasian population disproving my first hypothesis. If the CKD prevalence data is a fair estimate and only a small proportion progress then the answer may lie in how CKD progresses. There are several known factors that influence CKD progression including GFR and albuminuria category, cause of renal disease and hypertension. Some of these risk factors are modifiable and need to be identified and managed in order to impact on long term outcomes including death, cardiovascular events and disease progression. Acute kidney injury (AKI) is also rising in incidence and is complicated by high mortality rates, increased risk of cardiovascular events and more recently CKD progression. Little is known about the impact of more minor episodes occurring in the community on renal outcome. The second part of this study examined the relationship of multiple episodes of community AKI with CKD progression in a population of patients with CKD stage 3-5 referred to renal services. In this observational study, patterns of CKD progression were assessed and multiple AKI events were recorded. This study demonstrated a clear relation between multiple AKI events and CKD progression however only low eGFR at referral, diabetes and albuminuria were independent risk factors associated with disease progression. During the study it emerged that there were two patterns of CKD progression. In comparison to the more commonly assumed linear decline, the more common pattern was a stepwise progressive pattern characterised by accelerated rates of decline followed by a period of stability. Multiple AKI events were significantly more common in the stepwise progressive group suggesting AKI may have an important role as a promoter of CKD progression. This study suggests that community AKI is a modifiable risk factor that needs identifying at early stages in order to minimise risk of poor outcomes including CKD progression.
8
Mohr, Susanne. "Praxisgerechte Bestimmung der glomerulären Filtrationsrate (GFR) beim Hund an Hand eines Zwei-Schritt-Verfahrens." Berlin : Mensch-und-Buch-Verl, 2006. http://www.diss.fu-berlin.de/2006/520/index.html.
Full text
9
Viaud, Christophe. "Étude du comportement thermique de l'hélium implanté dans le liner molybdène du Réacteur GFR." Lyon 1, 2009. http://n2t.net/ark:/47881/m6gt5k99.
Full textAbstract:
Le liner métallique à confiner le matériau combustible des plaques GenIV doit, pour tenir son rôle, supporter « l'agression » des flux de neutrons rapides et d’impuretés implantées (produits de fission, hélium). Le travail de thèse présenté a contribué à la compréhension des mécanismes de fragilisation dans les métaux sous irradiation : il propose un modèle pour la nucléation et la croissance de bulles de gaz tels que l’hélium. L’approche utilisée couple une démarche de modélisation à une démarche expérimentale. Des mesures de relâchement obtenues par les techniques de spectrométrie de masse (TDS) et d’analyse par la réaction nucléaire (NRA) ainsi que des caractérisations par microscopie électronique en transmission (MET) ont été réalisées. Le développement d’un modèle simplifié de dynamique d’amas a permis d’interpréter le couplage entre la dynamique de relâchement de l’hélium et celle des bulles. Ce modèle a permis d’une part, de simuler les expériences d’implantation/récuit à partir d’un jeu de grandeurs physiques cohérentes avec celle de la littérature, et d’autre part, de mettre en évidence un couplage fort entre les concentrations des espèces libres (atomes d’hélium et lacunes) et la composition moyenne des bulles. Les dynamiques singulières de relâchement du gaz observées expérimentalement ont pu être expliquées par le mûrissement d’une population de bulles, initialement « surpressurisées », qui poursuivent leur croissance en réduisant leur concentration totale et leur pression<br>The metal liner dedicated to continue the fuel assembly of the Gas Fast Reactor, is intended to resist to a fast neutron flux and the implantation of impurities such as helium and the fission products. This PhD work contributes to the understanding of one of the mechanisms inducing the metal embrittlement under irradiation; it deals with a model that predicts the nucleation and growth of gas bubbles, such as helium, into a metal. The approach of the thesis relies on both theoretical and experimental works. The gas release measurements have been performed with the Nuclear Reaction Analysis (NRA) method and the Thermal Desorption Spectrometry (TDS); the bubbles characterization performed by Transmission Electronic Microscopy (TEM). The development of a simple model for the description of the cluster dynamic (clusters composed by defects and gas atoms) proposes some explanations for the coupling between the dynamics of the helium release and the bubbles evolution. This model enables to simulate the implantation experiments and the following annealing sequences, with a relevant physical dataset and coherent with the literature. Moreover it enhances the strong inference between the species concentration into the bulk (vacancies and helium atoms) and the mean composition of the bubbles. The peculiar dynamics of the gas release observed during the experiments, initially rapid and then significantly reduced , would be due to the ripening of the bubbles, pressurized after the room temperature implantation, which keep on growing and reducing their concentration and internal pressure
10
Rubel, Johanna [Verfasser]. "Bedeutung der GFR-adjustierten Harnsäureberechnung zur Prädiktion von kardialer Morbidität und Mortalität / Johanna Rubel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1237104963/34.
Full text
11
Wilson, Katherine E. "Evaluation of iohexol clearance to estimate glomerular filtration rate in normal horses." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/31970.
Full textAbstract:
In adult horses and foals, renal dysfunction can occur as a secondary complication to gastrointestinal disorders, dehydration, septicemia, endotoxemia and nephrotoxic drug administration. Measurement of renal function is an important feature not only in the diagnosis, but also in the prognosis and management of renal disease. Commonly used drugs such as phenylbutazone and gentamicin can be highly nephrotoxic under certain conditions.
Estimation of the glomerular filtration rate (GFR), accepted as one of the earliest and most sensitive assessments of renal function, can be determined in horses using standard techniques such as endogenous or exogenous renal creatinine clearance. These techniques can be time consuming, dangerous to perform on fractious patients, require trained personnel and are subject to errors most often associated with improper or incomplete urine collection. Recently, tests using iohexol, a radiographic contrast agent, have been developed to estimate the GFR in human beings, pigs, sheep, dogs, cats and horse foals with results that have been validated by traditional standards.
Serum clearance of a substance that is freely filtered by the kidneys without tubular secretion or reabsorption, that is not protein bound, and that is not metabolized, is a measurement of glomerular filtration rate. Iohexol meets all of these requirements and thus its clearance from serum should accurately estimate GFR. Utilization of serum clearance studies for estimation of GFR provides a clinically feasible and reproducible method in order to measure GFR in horses. Other commonly used methods to assess renal function in horses are fraught with inherent and operator error. Serum clearance of iohexol does not necessitate collection of urine and has been shown to be a safe, reproducible method using collection of timed blood samples to assess renal function in humans and animals. The objectives of this project were 1) to determine a method of estimation of GFR based on serum clearance of a substance that meets the requirements of a marker for GFR, and 2) to make the method clinically applicable by developing a method using two blood samples to derive clearance and thus GFR in normal adult horses.
Results of this study showed good agreement between GFR derived by exogenous creatinine clearance and serum clearance of iohexol. In addition, GFR values for all horses using either method were within published reference ranges for this species. The results of this study indicate that a single intravenous injection of iohexol at a dose of 150 mg/kg, followed by collection of 2 serum samples at 3 and 4 hours post injection can be used to estimate the GFR in healthy horses.<br>Master of Science
12
Almond, Gregory Thomas Hudson Judith A. "Depth-corrected versus non depth-corrected GFR determination by quantitative renal scintigraphy in the dog." Auburn, Ala, 2009. http://hdl.handle.net/10415/1653.
Full text
13
Hafstad, Ulrika, and Amanda Lundén. "Jämförelse av CKD-EPI och MDRD ekvationsformler för estimerad glomerulär filtrationshastighet." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-72648.
Full textAbstract:
Bakgrund: Inom yrket som röntgensjuksköterska används dagligen kontrastmedel i samband med undersökningar. För att räkna ut hur mycket kontrastmedel som patienter ska erhålla för att förebygga kontrastinducerade njurskador används ekvationsformler för att räkna ut njurfunktionens glomerulära filtrationshastighet. Två formler som jämfördes var CKD-EPI och MDRD. Syfte: I denna litteraturstudie var syftet att jämföra vilken av de två mest förekommande ekvationsformler är mest optimal att använda för att räkna ut estimerat GFR. Metod: Denna studie genomfördes i form av en litteraturstudie där 11 artiklar kvalitetsgranskades och sammanställdes. Resultat: CKD-EPI-formeln uppvisade generellt bättre prestationsförmåga för noggrannhet, precision och avvikelse än MDRD-formeln för estimering av GFR. Dock hade båda ekvationerna svagheter och är inte universella då MDRD och CKD-EPI-formlerna inte är lämpliga att använda på alla individer. Slutsats: I dagsläget är CKD-EPI-formeln den som ter sig vara mest användbar, dock behövs det mer forskning för att kunna utveckla ekvationsformler som passar för alla typer av patienter.<br>Background: In the profession as radiology nurse contrast media is used daily in radiologic examinations. In order to determine the volume of contrast media that patients should be administered and to prevent contrast-induced nephropathy equation formulas are applied to calculate the kidney function glomerular filtration rate. Two formulas were compared the CKD-EPI and MDRD. Aim: In this literature study the aim was to compare which of the two most commonly used equation formulas is the most optimal for calculating estimated GFR. Methods: This study was conducted as a literature study, where 11 articles were quality assessed and compiled. Results: The CKD-EPI formula generally showed better performance for estimating GFR in accuracy, precision and bias than the MDRD formula. However, both equation formulas present inadequacies and are not universal as they are not applicable to all individuals. Conclusions: At the moment the CKD-EPI formula appears to be the most applicable, although more research is required in order to develop equation formulas which cater to all types of patients.
14
Berglund, Linnea, and Sara Lundin. "En sammanställning av kreatinin och cystatin C vid skattning av glomerulär filtrationshastighet : En litteraturöversikt." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-60883.
Full textAbstract:
Inledning: Undersökningar som inkluderar kontrastmedel har ökat på datortomografin (DT). Inför kontrastmedelsundersökningar ska den glomerulära filtrationshastigheten (GFR) estimeras för att få ett mått på patientens njurfunktion. I nuläget finns det två olika markörer som kan användas till detta, kreatinin och cystatin C. Det är röntgensjuksköterskans ansvar att skatta GFR för att kunna göra en bedömning om patienten kan utföra undersökningen. Syfte: Syftet med studien var att sammanställa studier som jämför kreatinin och cystatin C vid skattning av GFR. Metod: Den här studien genomfördes som en allmän litteraturöversikt. Litteratursökningen genomfördes i databaserna CINAHL, PubMed och SveMed+. Tio kvantitativa vetenskapliga artiklar lokaliserades och gick vidare till analys. Resultat: Resultatet visade att cystatin C i många fall var en bättre indikator för att estimera GFR. Slutsats: För äldre och njursjuka ansågs cystatin C vara en bättre markör för njurfunktionen. Dock anser författarna att det krävs vidare forskning inom ämnet och dess påverkande faktorer för att kunna introducera cystatin C som ny njurfunktionsmarkör.
15
Mohr, Susanne [Verfasser]. "Praxisgerechte Bestimmung der glomerulären Filtrationsrate (GFR) beim Hund an Hand eines Zwei-Schritt-Verfahrens / vorgelegt von Susanne Mohr." Berlin : Mensch-und-Buch-Verl, 2006. http://d-nb.info/981933017/34.
Full text
16
Persson, Patrik. "Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-195956.
Full textAbstract:
Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. These findings are likely to be intertwined in a mechanistic pathway to kidney damage and this thesis investigated their roles in the development of diabetic nephropathy. In vivo, diabetes-induced oxidative stress stimulates renal tubular Na+ transport and in vitro, proximal tubular cells from diabetic rats display increased transport-dependent oxygen consumption, demonstrating mechanisms contributing to decreased kidney oxygenation. In control animals, endogenous adenosine reduces vascular resistance of the efferent arteriole via adenosine A2-receptors resulting in reduced filtration fraction. However, in diabetes, adenosine A2-signalling is dysfunctional resulting in increased GFR via increased filtration fraction. This is caused by reduced adenosine A2a receptor-mediated vasodilation of efferent arterioles. The lack of adenosine-signaling in diabetes is likely due to reduced local adenosine concentration since adenosine A2a receptor activation reduced GFR only in diabetic animals by efferent arteriolar vasodilation. Furthermore, sub-optimal insulin treatment also alleviates increased filtration pressure in diabetes. However, this does not affect GFR due to a simultaneously induction of renal-blood flow dependent regulation of GFR by increasing the filtration coefficient. In diabetes, there is decreased bioavailability of nitric oxide, resulting in alterations that may contribute to diabetes-induced hyperfiltration and decreased oxygenation. Interestingly, increased plasma concentration of l-arginine, the substrate for nitric oxide production, prevents the development of increased GFR and proteinuria, but not increased oxygen consumption leading to sustained intra-renal hypoxia in diabetes. This thesis concludes that antioxidant treatment directed towards the NADPH oxidase as well maneuvers to promote nitric oxide production is beneficial in diabetic kidneys but is targeting different pathways i.e. transport-dependent oxygen consumption in the proximal tubule by NADPH oxidase inhibition and intra-renal hemodynamics after increased plasma l-arginine. Also, the involvement and importance of efferent arteriolar resistance in the development of diabetes-induced hyperfiltration via reduced adenosine A2a signaling is highlighted.
17
Nordquist, Lina. "Novel Approaches to Treatment and Prevention of Diabetic Nephropathy." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8308.
Full textAbstract:
<p>Several studies have reported beneficial effects of C-peptide supplementation in diabetic patients and animal models of insulinopenic diabetes. However, it is also established that good glycemic control is essential to minimize the risk of diabetes-induced complications. This thesis investigates potential mechanisms for the beneficial effect of C-peptide on glomerular hyperfiltration, and a novel, painless route of insulin administration.</p><p>The results demonstrate that both C-peptide and its C-terminal penta-peptide sequence reduce the diabetes-induced glomerular hyperfiltration within an hour. The results also indicate that C-peptide possibly reduces diabetes-induced hyperfiltration via three different mechanisms: 1. Constriction of the afferent arteriole was demonstrated on isolated vessels from diabetic mice. 2. A net dilation of the efferent arteriole was evident <i>in vivo</i>. 3. Inhibition of the Na<sup>+</sup>/K<sup>+</sup>-ATPase was demonstrated <i>in vivo</i> in diabetic rats as well as <i>in vitro</i> on isolated proximal tubular cells from diabetic rats. All these mechanisms are known regulators of the net glomerular filtration pressure.</p><p>The last part of this thesis demonstrates that intradermal administration with a newly developed patch-like microneedle device results in similar insulin concentration compared to standard subcutaneous delivery. </p><p>These findings provide an insight for the beneficial effects of C-peptide on diabetic kidney function, and shows that this effect can be achieved by infusion of the C-terminal penta-peptide sequence alone. This thesis also presents a novel, painless alternative to insulin injections that is controllable, requires minimal training, and therefore presents several advantages compared to current standard therapy.</p>
18
Lösment-Wendelmuth, Amina [Verfasser]. "Die Bedeutung unterschiedlicher Messzeiträume bei der invasiven GFR-Messung mit Iohexol bei chronisch niereninsuffizienten Patienten über 70 Jahren / Amina Lösment-Wendelmuth." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1133492509/34.
Full text
19
Wagner, Mirjam [Verfasser], and Danilo [Akademischer Betreuer] Fliser. "Miniaturisierung einer Methode zur Abschätzung der Nierenfunktion (GFR und ERPF) an gesunden und 5/6-nephrektomierten Mäusen / Mirjam Wagner. Betreuer: Danilo Fliser." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1074138910/34.
Full text
20
Biglarnia, Ali-Reza. "Minimizing Risks and Morbidity in Live Kidney Donors." Doctoral thesis, Uppsala universitet, Transplantationskirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134511.
Full textAbstract:
Live kidney donors are healthy volunteers who are exposed to major surgical procedure and physical harms with no direct therapeutic benefits. Efforts to minimize their risks and morbidity are therefore of utmost importance. The current thesis describes studies on donor evaluation, surgical procedure and postoperative management of live kidney donors. The overall purpose is to evaluate and possibly improve routines and treatments in order to reduce risks and the overall morbidity of live kidney donors. In Study I, we evaluated the assessment of kidney function during donor evaluation and found that the accuracy of iohexol glomerular filtration rate (GFR) is compromised by large variations in repeated measurements in presumably healthy donors. We proposed that there is a need for improvement of GFR measurements and that the assessment of predonation kidney function should be more comprehensive, involving GFR, laboratory investigations, functional and morphological examinations and sound clinical judgment. In Study II, we addressed the risk of perioperative venous thromboembolism (VTE) and concluded that expanding the standard screening protocol for VTE to include perioperative venous duplex can potentially decrease the VTE-related morbidity. In studies III and IV, we investigated the impact of hand-assisted retroperitoneoscopic (HARS) nephrectomy on donor safety and perioperative morbidity. The HARS nephrectomy uses the hand-assisted approach, which enables immediate manual compression for hemostasis in case of sudden and severe bleeding. Additionally, the pure retroperitoneal access further increases the safety margin of laparoscopic donor nephrectomy by 1) minimizing the risk of intestinal injury, and 2) exposure of the retroperitoneal nerves, making HARS suitable for continuous infusion of local anesthetics (CILA). CILA effectively reduces the need for opioid consumption and has the potential to totally obviate opiate analgesics postoperatively. Consequently, CILA in combination with HARS reduces morphine-related morbidity and promotes postoperative recovery. In accordance with these data, we recommend improvement and modification of the donor evaluation process as well as a broad introduction of HARS nephrectomy in combination with CILA to increase the safety margin for live kidney donors.
21
Åkerblom, Axel. "Biomarkers of Renal Function in Acute Coronary Syndromes." Doctoral thesis, Uppsala universitet, Kardiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197852.
Full textAbstract:
The thesis aimed to investigate cystatin C and creatinine-based estimates of glomerular filtration rate (eGFR), both at admission and during follow-up, on the combined endpoint of cardiovascular death and myocardial infarction in patients with acute coronary syndrome (ACS). We also evaluated two cystatin C assays and assessed genetic determinants of cystatin C concentrations. We used the PLATelet inhibition and Patient Outcomes study, where all types of ACS patients (n=18624) were randomized to ticagrelor or clopidogrel treatment. Multivariable Cox regression models, including clinical variables and biomarkers (troponin and NT-proBNP), and c-statistics were calculated. Cystatin C and the creatinine-based CKD-EPI equation exhibited similar significant prognostic impact on the combined endpoint, with Area Under Curves (AUC) 0.6923 and 0.6941, respectively. Follow-up samples of renal biomarkers did not improve risk prediction. Patients randomized to ticagrelor treatment were associated with a non-sustained larger increase in renal markers at discharge, but neither the change nor the difference between the randomized groups affected cardiovascular risk. Two different cystatin C assays exhibited good correlation 0.86 (95% confidence interval 0.85-0.86), however moderate level of agreement. Risk prediction with a combination of creatinine and cystatin C did not outperform the creatinine-based CKD-EPI equation, AUC: 0.6913 and 0.6924, respectively (n=13050). The genetic polymorphism rs6048952 independently affected the cystatin C concentration with mean levels of 0.85mg/L, 0.80mg/L and 0.73mg/L for the A/A, A/G, and G/G genotypes, respectively. The genetic polymorphism did not affect outcome overall, however in the non-ST-elevation ACS subgroup a signal that genetic polymorphism may be associated with cardiovascular death was observed (p=0.002). In conclusion: cystatin C or eGFR, irrespective of equation or assay, are important cardiovascular risk factors in ACS patients. Nonetheless, the incremental value of adding any renal variable, to a multivariable risk model, is small. Further research on the impact of cystatin C genetic polymorphism is warranted.<br><p>PhD, i medicin.</p>
22
Moser, Elvina. "ANALYSIS OF DIFFERENCES IN AUGMENTED RENAL CLEARANCE CASES AND THEIR RELEVANCE TO PHARMACOKINETICS." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_232652-68683.
Full textAbstract:
In recent years, the focus on augmented renal clearance increased as it was found by other researchers to result in subtherapeutic drug dosing concentrations. Accurate assessment of renal function is important for prescribing optimal dosis of pharmaceuticals for ARC patients.
Objective of the work: The purpose of this quantitative retrospective comparative study was to register possible cases of Accelerated renal clearance in patients of Hospital of Lithuanian University of Health Sciences Kaunas Clinics and analyse the differences in assessments of cases of Augmented Renal Clearance and the possible risks of ARC for therapy.
Tasks: To achieve the objective several tasks were raised: 1) to register possible ARC patients cases as assessed by Cocroft-Gault and their possible associated reasons; 2) to analyse differences in three for GFR estimation used equations (Cocroft-Gault, MDRD simplified, and CKD-EPI). 3) determine the risk drugs for changed renal elimination.
Methodology: ARC survey (appendix 1) was filled about patients from various departments of Clinics during the period of 2013 03-04 – 2013 12-20. All patients were selected according serum creatinine values that were 50 µmol/l. or less. Two goups of patients were assigned for analysis: patients were grouped according Cocroft - Gault creatinine clearance values: (1) ARC group A CrCl >130 ml./min and (2) comparative Non-ARC group B CrCl 90-130 ml./min. In the group A were 31 and in the group B - 5 patients... [to full text]<br>Pastaraisiais metais labai išaugo tyrimų apie padidintą inkstų klirensą (PIK), nes pagal keleto tyrejų duomenis šios būklės pasekmė yra subterapinės vaistų koncentracijos. Tikslus inkstų funkcijos nustatymas yra labai svarbus norint parinkti optimalias terapines vaistų dozes padidinto inkstų klirenso pacientams.
Darbo tikslas: Šio kiekybinio retrospektyvaus palyginamojo darbo tikslas buvo surinkti duomenis apie padidinto inkstų klirenso PIK atvejus Lietuvos sveikatos mokslų universiteto ligonines Kauno klinikose. Buvo siekiama išanalizuoti sirtumus tarp skirtingų PIK įvertinimo būdų ir įvertinti galimas PIK rizikas terapijai
Uždaviniai: norint pasiekti užsibrėžtus tikslus šie uždaviniai buvo iškelti: 1) užregistruoti PIK atvejus ir nustatyti jų galimas priežastis. 2) apskaičiuoti GFG trimis skirtingomis formulėmis (Cocroft-Gault, MDRD, CKD-EPI) ir išanalizuoti skirtumus. 3) nustatyti vaistus, kurie gali būti pakitusios inksų eliminacijos rizikoje.
Metodika: PIK anketa ( 1 priedas) buvo pildoma apie pacientus iš skirtingų Kauno klinikų skyrių, laikotarpiu nuo 2013 04 03 iki 2013 12 20. Visi pacientai buvo parinkti pagal kreatinino kiekį serume – 50 µmol/l.. ir mažiau. Dvi pacientų grupės buvo parinktos analizei: pacientai buvo sugrupuoti pagal kreatinino klirensą į (1) PIK A grupę – CrCl > 130 ml./min. ir (2) palyginamąją B grupę – CrCl 90-130 ml./min. A grupėje buvo parinktas 31 pacientas ir B grupėje 5 pacientai.
Rezultatai: Vidutinės GFG reikšmės tiriamojoje... [toliau žr. visą tekstą]
23
El-Khoury, Joe M. "Chronic Kidney Disease: Vitamin D Treatment Regimens and Novel Assay Development for Kidney and Cardiovascular Function Biomarkers." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1343914060.
Full text
24
Ingremeau, Jean-Jacques. "Méthodologie d’optimisation d’un coeur de réacteur à neutrons rapides, application à l’identification de solutions (combustible, coeur, système) permettant des performances accrues : étude de trois concepts de coeurs refroidis à gaz, à l’aide de l’approche FARM." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112253/document.
Full textAbstract:
Dans l’étude de tout nouveau réacteur nucléaire, la conception de son cœur est une étape décisive. Or il s’agit d’un problème complexe, qui couple fortement la neutronique, la thermomécanique du combustible et la thermo-hydraulique. Actuellement cette conception se fait par longues itérations successives entre les différentes spécialités. Afin d’optimiser de façon plus globale et complète la conception d’un cœur, une nouvelle démarche appelée FARM (FAst Reactor Methodology) a été développée dans le cadre de la thèse. Elle consiste à établir des modèles simplifiés de neutronique, mécanique et thermo-hydraulique, sous forme analytique ou d’interpolation de calculs de codes de référence, puis à les coupler, de manière à pré-dimensionner automatiquement un cœur à partir de variables d’optimisation. Une fois ce modèle établi, on peut explorer et optimiser directement de nombreux cœurs, à partir d’algorithmes génétiques de façon à améliorer leurs performances (inventaire Plutonium en cycle, …) et leur sûreté (estimateurs de sûreté pour accidents protégés et non-protégés). Une réflexion a également due être menée pour déterminer les performances d’un cœur, ainsi que la façon de prendre en compte la sûreté. Cette nouvelle approche a été utilisée pour optimiser la conception de trois concepts de cœurs de Réacteur à Neutrons Rapides refroidi au Gaz (RNR-G). Tout d’abord, la conception du RNR-G à combustible carbure et à aiguilles en SiC a pu être optimisée. Les résultats ont permis d’une part de démontrer que le cœur de référence issu de la méthode itérative était optimal (c'est-à-dire sur le front de Pareto). D’autre part, l’optimisation a également permis de proposer de nombreux autres cœurs, où en dégradant un estimateur de sûreté ou une performance (sur lesquels des marges étaient disponibles), on améliore les autres performances. Une évolution de ce concept utilisant la nouvelle technologie du buffer, a également été modélisée dans FARM et optimisée. FARM a ainsi permis de proposer les premières images de cœur GFR carbure gainé en SiC utilisant la technologie buffer, et d’estimer leurs performances. Les résultats obtenus montrent que cette innovation permet d’atteindre des cœurs beaucoup plus performants et/ou beaucoup plus « sûrs » (plusieurs profils de cœurs étant proposés). Une troisième application de FARM a été réalisée sur un concept de GFR carbure gainé en Vanadium, où là aussi FARM a proposé les premières images de cœur. Toutefois les grandes incertitudes en jeu ne permettent pas véritablement de conclure sur les performances de ce concept, qui semble prometteur.Ainsi, la faisabilité d’une optimisation globale, couplant les différentes physiques d’un cœur de réacteur nucléaire a été démontrée. Si la méthode ainsi obtenue (FARM) est moins précise que la méthode classique, elle permet d’explorer et d’optimiser beaucoup plus rapidement (en quelques semaines au lieu de quelques mois) un grand nombre de cœurs et est parfaitement adaptée pour l’étape de préconception des cœurs de réacteurs ; d’autres études détaillées permettant ensuite d’affiner l’image de cœur retenue<br>In the study of any new nuclear reactor, the design of the core is an important step. However designing and optimising a reactor core is quite complex as it involves neutronics, thermal-hydraulics and fuel thermomechanics and usually design of such a system is achieved through an iterative process, involving several different disciplines. In order to solve quickly such a multi-disciplinary system, while observing the appropriate constraints, a new approach has been developed to optimise both the core performance (in-cycle Pu inventory, fuel burn-up, etc…) and the core safety characteristics (safety estimators) of a Fast Neutron Reactor. This new approach, called FARM (FAst Reactor Methodology) uses analytical models and interpolations (Metamodels) from CEA reference codes for neutronics, thermal-hydraulics and fuel behaviour, which are coupled to automatically design a core based on several optimization variables. This global core model is then linked to a genetic algorithm and used to explore and optimise new core designs with improved performance. Consideration has also been given to which parameters can be best used to define the core performance and how safety can be taken into account.This new approach has been used to optimize the design of three concepts of Gas cooled Fast Reactor (GFR). For the first one, using a SiC/SiCf-cladded carbide-fuelled helium-bonded pin, the results demonstrate that the CEA reference core obtained with the traditional iterative method was an optimal core, but among many other possibilities (that is to say on the Pareto front). The optimization also found several other cores which exhibit some improved features at the expense of other safety or performance estimators. An evolution of this concept using a “buffer”, a new technology being developed at CEA, has hence been introduced in FARM. The FARM optimisation produced several core designs using this technology, and estimated their performance. The results obtained show that this innovative feature leads to much higher performing and/or safer cores. The FARM approach has also been applied to a GFR concept using a vanadium cladding. However the large uncertainties involved do not really enable one to evaluate the performance of this promising concept.In summary, the feasibility of a global multi-disciplinary optimization has been demonstrated. Although the resulting method (FARM) is less accurate than the conventional method, it allows fast optimization and permits a large number of cores to be explored quickly, and is ideally suited for the preliminary designs studies before further refinement of the core design
25
Pelzer, Maximilian [Verfasser], Edwin [Akademischer Betreuer] Bölke, and L. Christian [Akademischer Betreuer] Rump. "Bestimmung der glomerulären Filtrationsrate (GFR) mittels Cystatin C - und Kreatinin basierter Formeln im Vergleich zur 51 Cr-EDTA-Plasma Clearance (Referenzmethode) bei Patienten mit Kopf-Hals Tumoren / Maximilian Pelzer. Gutachter: Edwin Bölke ; L. Christian Rump." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2012. http://d-nb.info/102027333X/34.
Full text
26
Karlsson, Robert. "Tappning av datanätverk : Vad är det som gör att det går långsamt?" Thesis, Mittuniversitetet, Avdelningen för informations- och kommunikationssystem, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-28253.
Full textAbstract:
I ett datanätverk är det många som ska dela på de resurser som finns, av det kan användaren uppleva att nätverket går långsamt. Denna rapport gör en undersökning på Nya Slottet Bjärka Säby i Linköping varför deras nätverk upplevs långsamt. Genom att utföra en nätversktappning kunde en baseline skapas för att sedan ta ut information genom ett Perl skript. Resultatet visa inga direkta problematik på nätverket, men det noterades att IPv6 förekom på nätverket som är onödigt protokoll för detta nätverk. Det rekommendera alltså att avaktivera IPv6 så långt det är möjligt. Undersökningen varade under en vecka och har för lite information för att ge en riktigt förklaring för den upplevda hastigheten och det rekommenderas att göra flera tester, för att kunna hitta det eventuella felet.<br>In a computer network there are many users that need to share the same resources and by that the user may experience the network to be very slow. This report investigate the network in Nya Slottet Bjärka Säby i Linköping why it is slow. Be doing a network tapping and collecting whats on the network, with a written Perl script that graphed out collected data, showed that no direct problem could be pointed out. It was noted that IPv6 was present on the network, that for this network is unnecessary and it's recommend to turn it off where it's possible. The investigation was for a week and shows to little information to find the real problem for the network speed. It recommends that more testing is performed to find the problem.
27
Onety, João Luiz Rodrigues. "A queda do muro de Berlim no espaço público do Brasil- 1989- 1990. A análise dos jornais O Globo do Rio de Janeiro e Jornal do Commercio do Amazonas." Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/28949.
Full textAbstract:
O processo que levou à queda do Muro de Berlim vai além do dia 9 de novembro de
1989 quando a população alemã-oriental pôde pela primeira vez abraçar os
compatriotas ocidentais. Desde 1945, as nações estavam alarmadas, sentindo a ameaça
de um possível combate armado entre as duas maiores potências vencedoras da
Segunda Guerra Mundial, EUA e URSS. Os confrontos armados não aconteceram, no
entanto, as tensões se agravaram dali em diante, fazendo com que as relações entre os
principais líderes mundiais se tornassem mais difíceis, devido à competição por quem
seria o país a ter o protagonismo no cenário mundial, era o início da Guerra Fria. Durante
anos capitalismo e socialismo estiveram numa gangorra, porém com as crises
econômicas, o sistema socialista/ comunista foi perdendo força e deu margem às
manifestações em diversos países do leste europeu, o que causou um terremoto nas
bases comunistas pelo continente até chegar ao fim desta ideologia, que pode ser
simbolizado pela queda do Muro de Berlim e posteriormente a Reunificação Alemã,
quando a República Democrática Alemã (RDA) já não tinha mais escolhas face às
dificuldades sociais e econômicas, abandonando o sistema socialista para se integrar à
República Federal Alemã (RFA), que passaria a ser um só país. Enquanto isso, o Brasil
também estava numa transição de ditadura para democracia, experimentando a mesma
sensação alemã em circunstâncias diferentes, mas sem dúvida com influências do que
vinha acontecendo na Europa, algo que pode ter contribuído para as bases de sua
redemocratização. Este trabalho pretende mostrar qual o impacto dos eventos
europeus da década de 1980, precisamente os do ano de 1989 e como eles foram
absorvidos pela mídia brasileira por meio de dois jornais impressos, que revelam através
da abordagem das notícias, muito sobre suas linhas editoriais e seus interesses. Além
disso, este meio de comunicação é uma fonte inesgotável de informações preciosas
sobre esse período conturbado do século XX; the newspapers O Globo from Rio de Janeiro and Jornal do Commercio from Amazonas
ABSTRACT:
The process that led to the fall of the Berlin Wall goes beyond the November 9th, 1989
when the East German population was for the first time able to hug Western
compatriots. Since 1945, nations have been alarmed, feeling the threat of possible
armed combat between the two major World War II-winning powers, the US and the
USSR. Armed clashes did not take place, on the other hand, tensions became worse from
then on, making relations between the world's leading leaders more difficult, due to
competition for who would be the protagonist on the world scenario, it was the
beginning of the Cold War. For years capitalism and socialism have been on a seesaw,
but with the economic downturns, the socialist / communist system had been losing
strength and it has given rise to demonstrations in several eastern European countries,
which has caused an earthquake in the communist bases around the continent until its
end, that may be symbolized by the fall of the Berlin Wall and later with the German
Reunification, when the German Democratic Republic (GDR) had no longer choices in
the face of social and economic difficulties, leaving the socialist system to join the
German Federal Republic (GDR), which would be one country. Meanwhile, Brazil was
also in a transition from dictatorship to democracy, experiencing the same German
sensation under different circumstances, undoubtedly with influences of what was
happening in Europe, that may have contributed to the foundations of its
redemocratization. This paper aims to show the impact of European events of the 1980s,
precisely those of 1989 and how they were absorbed by the Brazilian media through
two newspapers, which reveal through their approach, much about their editorial lines.
Moreover, this means of communication is an inexhaustible source of precious
information about this troubled period of the twentieth century.
28
Ingremeau, Jean-Jacques. "Méthodologie d'optimisation d'un coeur de réacteur à neutrons rapides, application à l'identification de solutions (combustible, coeur, système) permettant des performances accrues : étude de trois concepts de coeurs refroidis à gaz, à l'aide de l'approche FARM." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00660567.
Full textAbstract:
Dans l'étude de tout nouveau réacteur nucléaire, la conception de son cœur est une étape décisive. Or il s'agit d'un problème complexe, qui couple fortement la neutronique, la thermomécanique du combustible et la thermo-hydraulique. Actuellement cette conception se fait par longues itérations successives entre les différentes spécialités. Afin d'optimiser de façon plus globale et complète la conception d'un cœur, une nouvelle démarche appelée FARM (FAst Reactor Methodology) a été développée dans le cadre de la thèse. Elle consiste à établir des modèles simplifiés de neutronique, mécanique et thermo-hydraulique, sous forme analytique ou d'interpolation de calculs de codes de référence, puis à les coupler, de manière à pré-dimensionner automatiquement un cœur à partir de variables d'optimisation. Une fois ce modèle établi, on peut explorer et optimiser directement de nombreux cœurs, à partir d'algorithmes génétiques de façon à améliorer leurs performances (inventaire Plutonium en cycle, ...) et leur sûreté (estimateurs de sûreté pour accidents protégés et non-protégés). Une réflexion a également due être menée pour déterminer les performances d'un cœur, ainsi que la façon de prendre en compte la sûreté. Cette nouvelle approche a été utilisée pour optimiser la conception de trois concepts de cœurs de Réacteur à Neutrons Rapides refroidi au Gaz (RNR-G). Tout d'abord, la conception du RNR-G à combustible carbure et à aiguilles en SiC a pu être optimisée. Les résultats ont permis d'une part de démontrer que le cœur de référence issu de la méthode itérative était optimal (c'est-à-dire sur le front de Pareto). D'autre part, l'optimisation a également permis de proposer de nombreux autres cœurs, où en dégradant un estimateur de sûreté ou une performance (sur lesquels des marges étaient disponibles), on améliore les autres performances. Une évolution de ce concept utilisant la nouvelle technologie du buffer, a également été modélisée dans FARM et optimisée. FARM a ainsi permis de proposer les premières images de cœur GFR carbure gainé en SiC utilisant la technologie buffer, et d'estimer leurs performances. Les résultats obtenus montrent que cette innovation permet d'atteindre des cœurs beaucoup plus performants et/ou beaucoup plus " sûrs " (plusieurs profils de cœurs étant proposés). Une troisième application de FARM a été réalisée sur un concept de GFR carbure gainé en Vanadium, où là aussi FARM a proposé les premières images de cœur. Toutefois les grandes incertitudes en jeu ne permettent pas véritablement de conclure sur les performances de ce concept, qui semble prometteur.Ainsi, la faisabilité d'une optimisation globale, couplant les différentes physiques d'un cœur de réacteur nucléaire a été démontrée. Si la méthode ainsi obtenue (FARM) est moins précise que la méthode classique, elle permet d'explorer et d'optimiser beaucoup plus rapidement (en quelques semaines au lieu de quelques mois) un grand nombre de cœurs et est parfaitement adaptée pour l'étape de préconception des cœurs de réacteurs ; d'autres études détaillées permettant ensuite d'affiner l'image de cœur retenue.
29
Olsson, Patrik. "I den Tysta Kunskapens Stjärnljus : Eller hur gör man när månen går i moln?" Thesis, Linnéuniversitetet, Institutionen för fysik och elektroteknik (IFE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-44863.
Full textAbstract:
The purpose of this thesis is to highlight how tacit and silenced knowledge appear in various contexts in the nuclear power industry. Attention is paid primarily to the dilemma that the instructor is faced in the teaching of courses and programs of theoretical and practical nature. Organization and leadership are considered to be important parameters in the education context as well. The method used is called “the dialogue seminar method”. The empirical material has its foundation in the examples that originates from the dialogue seminar sessions in the masters programme, as well as from previous dialogue seminar series at KSU. From a linguistic perspective, some parts of the text have gone the whole hog out in order to create a greater depth in what is written. Some call it poetry. The thesis considers that tacit knowledge takes a long time to achieve, but it can be lost quickly. It also describes various dilemmas associated with knowledge and learning, from both the instructor and the student's perspective. The thesis demonstrates the importance of the three knowledges, namely propositional, procedural and personal knowledge. These three types of knowledges can not be separated. For example, if procedural knowledge is reduced to a minimum, it will affect the other two as well. Since the aim is to highlight training in the nuclear power industry, the primary goal has not been to achieve any specific results. But what emerges is the importance of an organization or leadership which does not restrict the individual, but affirms thirst for knowledge and desire to do good work. Furthermore, it is needed to create opportunities for “on the job training” and in the continuation of self-development. The thesis also shows the importance of welcoming new employees in a good way as well as how knowledge from a colleague who will retire or quit is conveyed to another employee. In the nuclear power industry, "operational excellence" refers as something to strive for. But what it means or how it affects instructor’s practice is not defined yet. Excellence can be seen as something that comes from within oneself and cannot come from outside and in.<br>Syftet med den här uppsatsen är att lyfta upp tyst och tystad kunskap och hur den ter sig i olika sammanhang i kärnkraftsbranschen. I första hand ägnas uppsatsen åt de dilemman som instruktören står inför vid genomförande av kurser och utbildningar av teoretisk och praktisk karaktär. Även organisation och ledarskap beaktas som viktiga parametrar i sammanhanget utbildning. Uppsatsen syftar inte till att ge några entydiga svar och gör inte heller anspråk på att komma med lösningar. I de resonemang som förs kommer emellertid svar och lösningar att beröras. Den metod som använts kallas för dialogseminariemetoden och den har tillämpats fullt ut genom de exempel som används. Det empiriska materialet bottnar i de exemplen som har sitt ursprung från de dialogseminarietillfällen som föregått uppsatsskrivandet i masterutbildningen samt från tidigare dialogseminarieserier. Sett ur ett språkligt perspektiv har svängarna tagits ut en del med syfte att skapa ett större djup i det som skrivs. En del kallar det för poesi. Då uppsatsen i första hand betraktar tyst kunskap kommer det fram att den tar lång tid att erövra, men kan förloras snabbt. Uppsatsen beskriver olika dilemman som hänger ihop med kunskap och kunskapsinhämtning både ur instruktörens samt kursdeltagarens perspektiv. Uppsatsen visar vikten av att de trekunskapstyperna påstående-, färdighets- och förtrogenhetskunskap inte glider ifrån varandra. Om till exempel förtrogenhetskunskapen reduceras till ett minimum kommer det att påverka de andra två kunskapstyperna också. Då syftet är ett belysa utbildning i kärnkraftsbranschen har målet inte varit primärt att nå några resultat. Men det som framkommer är vikten av att en organisation eller ledarskap inte begränsar individen utan bejakar kunskapstörst och viljan att göra ett bra arbete. Därtill kommer att skapa förutsättningar för verkspraktik och fortsatt egen utveckling. Uppsatsen visar också på vikten av att ta emot nyanställda på ett bra sätt såväl som hur kunskap förmedlas från en kollega som kommer att gå i pension. I branschen nämns "Operational excellence" som något att sträva efter. Men vad det innebär eller hur det påverkar instruktörernas praxis går inte att läsa ut än. Excellence kan ses som något som kommer inifrån en själv och kan inte komma utifrån och in.
30
Gosnell, Roxanne, Janice Lazear, Jean Croce Hemphill, and Deborah Dotson. "Development of Guidelines for Improving Oral Health for Individual with Parkinson’s Disease." Digital Commons @ East Tennessee State University, 2019. https://doi.org/10.1111/ger.12401.
Full textAbstract:
Objective: The purpose of this project was to develop evidence‐based clinical practice guidelines (CPGs) for the management of oral health (OH) for patients with Parkinson’s disease (PD).
Background: Individuals with PD have significantly poorer OH than the general population. Poor OH is a risk factor for systemic diseases, including cardiovascular disease, diabetes, and respiratory infections.
Materials and Methods: After an extensive literature review was completed, available evidence was evaluated for inclusion in the initial draft of the guidelines. The draft was then reviewed for content validity by experts in the areas of dentistry, dental hygiene and neurology using the Delphi method. After consensus among the content experts, final guidelines were completed. The final CPG was presented to individuals with PD and their caregivers at a support group. Participants were asked to review the information in the guidelines for 2 weeks and then submit a survey regarding the usefulness of the CPG. The CPG was also evaluated by practicing nurse practitioners (NPs) and dental hygienists using the AGREE II tool.
Results: Twenty people from the PD support group participated in the educational intervention, and surveys were received from 14 participants. Overall, participants agreed or strongly agreed with each statement related to the applicability and usefulness of the guidelines. The CPG was evaluated using the AGREE II tool, and scores were >80% in all domains with an overall score of 97.1%.
Conclusion: Development of these guidelines represent an initial step in improving the oral health and overall health of individuals with PD.
31
Massoud, Chadi. "Evaluation de la filtration glomérulaire par IRM." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20037.
Full textAbstract:
Cette étude cherche à évaluer le Débit de la Filtration Glomérulaire (DFG) dans le rein humain par IRM. L'estimation de ce paramètre quantitatif nécessite le suivi de la cinétique intrarénale de Gd après son injection en bolus. Pour atteindre cet objectif, nous avons développé sous IDEA Siemens une séquence SR-FLASH strictement pondérée en T1 capable de suivre en dynamique l'évolution du signal RMN après l'injection d'un bolus de produit de contraste. Cette séquence possède un codage de phase centré permettant de déterminer le contraste au début de la période d'acquisition de l'image. Nous avons également mis en oeuvre une séquence d'inversion IR-FLASH (avec codage de phase centré) permettant la mesure de la relaxation longitudinale en l'absence de produit de contraste, ce paramètre étant indispensable à la conversion de l'intensité du signal en concentration. Sachant que la relation entre l'intensité du signal RMN et la concentration de Gd n'est pas linéaire, nous avons proposé deux méthodes originales et malgré tout rapides et robustes pour convertir le signal RMN en concentration locale de Gd. Ceci nous a permis d'évaluer l'évolution de la concentration dans les deux reins et dans l'aorte au cours des premiers passages du produit. L'ajustement des ces mesures de concentration sur les équations décrivant une modélisation bicompartimentale de la fonction rénale a permis de calculer le DFG de chaque rein dans une population de cinq sujets possédant un fonctionnement rénal normal<br>This study seeks to assess the Glomerular Filtration Rate (GFR) in the human kidney by MRI. To quantitatively estimate this parameter requires monitoring of the intrarenal kinetics of Gd after its bolus injection. To achieve this goal, we have developed under IDEA Siemens a SR-FLASH T1-weighted MRI sequence which can follow dynamic NMR signal changes after a bolus injection of Gd. This sequence has a centric phase-encoding scheme, and thus the image contrast was determined at the beginning of the acquisition period. Subsequently, we have implemented an IR-FLASH (with centric phase-encoding scheme) sequence to measure the longitudinal relaxation time in the absence of any injection of Gd ; this parameter is required to convert NMR signal intensities into Gd concentrations. knowing that the relation between the NMR signal intensities and the Gd concentrations is not linear, we have proposed two novel methods and yet fast and robust for conversion of the NMR signal intensities into local Gd concentration. This allowed us to estimate the temporal evolution of Gd concentrations in both kidneys and aorta. The fit of these concentrations measurements by a two-compartments model describing the function of the kidney allowed us to calculate the GFR of each kidney in a population of five subjects with normal renal function
32
Olsson, Lars, and Oskar Eriksson. "Vad gör lärarna 3-4 år efter examen, hur trivs de och går trivseln att påverka?" Thesis, Linköping University, Department of Educational Science (IUV), 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1695.
Full textAbstract:
<p>I uppsatsen undersöker vi hur stor del av den grupp lärare som började grundskollärarutbildningen 1995 vid Linköpings universitet och som var inskrivna sista terminen som är verksamma i yrket och om de ser en framtid i yrket eller om de planerar att sluta. För att få en bakgrund till undersökningen har vi fördjupat oss i litteratur inom området och för att fram uppgifter om vår referensgrupp har vi bett dem fylla i en enkät. </p><p>Undersökningen visar att de allra flesta är nöjda med sitt yrkesval, men vi konstaterar att det finns stora brister i lärarnas arbetssituation vilket leder till omfattande fysiska och psykiska besvär samt tankar på att byta yrke. </p><p>De förändringar som avhoppade och aktiva lärare önskar sig är högre lön, mindre stress i form av tex. färre undervisningstimmar, mindre elevgrupper, mer resurser, mindre kringarbete samt fler specialister i skolan.</p>
33
Tufvesson, Ulrika. "Introduktion av mat till barn som ammas : Vad BVC ger för information och hur föräldrar gör." Thesis, Uppsala University, Department of Public Health and Caring Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113694.
Full textAbstract:
<p>In 2001 the World Health Organization (WHO) issued a revised global recommendation for exclusive breastfeeding for a child ´s first six months. The aim of this study was to investigate what information parents receiving from the Child Health Care about introduction of solids to breastfed infants and if they follow the recommendation. A further aim is to document reasons for introduction of solids at the selected time and describe what food parents start with.</p><p>The method has a descriptive and a qualitative design. Users of several Swedish parenting websites were asked to participate in the study. A total of 27 users completed the anonymous open-ended questions posted on the websites. Supplementary data (13 texts) were obtained from the forum discussions on parenting websites. Data were analyzed with content analysis.</p><p>Results: The new recommendation in Sweden from 2003 is introduction of solids at the age of 6 months. According to the parents the Child Health Care has recommended introduction of solids between 4 months and 6 months. A few of the parents said they got a double message, or received no recommendation. The timing when the first solids were given by the parents varied between 3 months and 10 months. The most common reason to introduce solids was that the “infant is interested in food”. Porridge made from commercial baby cereals, vegetarian purees or “finger food” was most commonly used for complementary food.</p><p> </p>
34
Andersson, Daniel, and Anna Jirestål. "Vad gör lärare när elever ”går bananas” i klassrummet? : Fem förstelärares metoder för att skapa ordning i klassrummet." Thesis, Linnéuniversitetet, Institutionen för utbildningsvetenskap (UV), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-31637.
Full textAbstract:
Idag är skolan ofta föremål för debatt i massmedia. Ett vanligt förekommande ämne är den bristande ordningen i klassrummen och hur den leder till försämrade resultat. Den allmänna uppfattningen är att hårdare disciplin är lösningen. Studiens syfte är därför att skildra hur fem förstelärare gör för att skapa ordning i sina klassrum. För att uppnå syftet utfördes kvalitativa intervjuer med utgångspunkt i en vinjett, vilken våra informanter fick ta del av. I analysen användes framför allt symbolisk interaktionism och ledarskapsteori som teoretiskt ramverk. Resultatet visade att inga av informanterna var för metoder så som skrämsel, kvarsittning, utkastning eller andra former av bestraffningar. Samtliga informanter uppvisade ett demokratiskt ledarskap och menade istället att trygghetsskapande är den bästa metoden i skapandet av en god arbetsmiljö. Ordningsregler och tydliga ramar menar de ska skapa trygghet och förebygga eventuella beteendeproblem hos eleverna, medan samtal ska hjälpa eleverna att förstå vad de gjort, om de trots allt skulle uppträda opassande. Detta för att hindra att eleven beter sig likadant igen. Vår förhoppning är att kunna bidra med tips och idéer till andra lärare om hur ordning kan skapas i klassrummet.<br>Today, school is often the subject of debate in the media. A common topic is the lack of order in the classroom and how it leads to poorer results. The general consensus is that tougher discipline is the solution. The aim of this study is to describe how five “förstelärare” create order in their classrooms. To achieve the aim, qualitative interviews based on a vignette were conducted, which our informants were presented with. To analyze the results different theories like symbolic interactionism and leadership theory were used. The results showed that none of the informants was positive to methods such as intimidation, detention, ejection or other forms of punishment. All informants reported a democratic leadership and instead argued for establishing of assurance as the best method, to create a good working environment. They mean that standards of conduct and clear instructions will provide assurance and prevent students’ behavior problems, while dialogs will help students to understand what they have done, so that they do not repeat their behavior. Our hope is to give other teachers tips and ideas on how order can be created in the classroom.
35
Gustafsson, Niklas, and Gustav Henningsson. "Maskinrums design och layout : Varför ett maskinrum ser ut som det gör och hur det går till vid planerandet?" Thesis, University of Kalmar, University of Kalmar, University of Kalmar, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-1835.
Full textAbstract:
<p>This report is founded in lack of knowledge concerning the design and layout procedureduring a new engine room construction.The prime question is how the engine room takes its form from idea to construction and whathappens in between. We want to give the reader a better understanding in how the work isdone and why it is designed the way it is concerning layout, ergonomics and safety. Duringthis report we will enhance the knowledge concerning regulations and rules that are of greatsubstance such as SOLAS, Swedish Sjöfartsverket and IMO.By contacting the parties involved in the process in newly designing a vessel and its engineroom, we will assume their approaches and experiences. We will study the work progressfrom planning to construction of a vessels machinery spaces. We will with the help ofinterviews with interested parties get an idea of the approach and also compare the finishedproduct a bit depending on company size and resources.The investigation resulted in a good basis for how a ship engine room design takes shape andwhich aspects are taken into account, however, we found that the existing rules concerningengine room layout was very vague and was seen as the most recommendations. For thecontrol room, there were however some points to consider. We believe that it would facilitatea more comprehensive legal framework relating to engine room design.</p><br><p>Denna studie grundar sig i en okunskap gällande maskinrums design och layout. Frågan viställde oss var hur ett fartygs maskinrum kom till från idé till ritning och slutligen beställning.Syftet med arbetet är att ge läsaren grundläggande kunskaper gällande maskinrums design,layout samt ergonomiska aspekter då detta är relevant gällande säkerhet och avhjälpandekring det dagliga arbetet ombord på ett fartyg. Vi kommer även ta upp information som rörregelverk så som (SOLAS, Sjöfartsverket och arbetsmiljöverket),riktlinjer (IMO) standarder (ISO).Genom att kontakta de parter som är inblandade i ett nykonstruerande av ett fartyg och dessmaskinrum kommer vi utgå ifrån deras tillvägagångssätt och erfarenheter. Vi kommer studeravägen från beställning och planering till konstruering. Vi kommer med hjälp av intervjuermed berörda parter skaffa oss en uppfattning om tillvägagångssättet vid planering avmaskinrums designen och även jämföra resultatet beroende på rederiets storlek och resurser.Undersökningen resulterade i ett bra underlag för hur ett fartygs maskinrums konstruktion tarform och vilka aspekter som det tas hänsyn till, dock upptäckte vi att reglerna gällandemaskinrummets utformning var mycket vaga och sågs mest som rekommendationer. Förkontrollrummet fanns det däremot en del punkter att ta hänsyn till. Vi anser att det skulleunderlätta med ett mer utförligt regelverk som rör maskinrummets utformning.</p>
36
Söderblom, Sigfrids Amanda, and Pettersson Annette Sigfrids. "Träning ger dig endorfiner och endorfiner gör dig glad. : En litteraturstudie om fysisk aktivitet som hälsofrämjande åtgärd vid depression." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72327.
Full text
37
Kühnel, Lennart [Verfasser]. "Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane / Lennart Kühnel." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1234150417/34.
Full text
38
Brodin, Pernilla, and Maria Lund. "Elever och lärares syn på läxor : Den som inte ger läxor tas på mindre allvar än den som gör det." Thesis, University of Gävle, Department of Education and Psychology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-3400.
Full text
39
Haster, Kerstin. "Barn gör inte som du säger, de gör som du gör." Thesis, Stockholm University, The Stockholm Institute of Education, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7572.
Full textAbstract:
<p>Sammanfattning och förord Studien fokuserar på lärarstudenters syn på fritidspedagogens roll för fostran av barn på fritidshem. Den franske sociologen Bourdieu och hans tankar om socialisation är studiens huvudsakliga teoretiska perspektiv. Bourdieu talar om fält, kapital, praktiskt sinne och habitus. I min studie jämför jag Bourdiues tankar med några pedagoger såsom Dewey och Säljö vilkas arbete är mer sociokulturell inriktat. För att tydliggöra hur fostran av barn på fritidshem sker har jag intervjuat tio blivande lärarstudenter vilka studerar med inriktning mot fritidshemmets pedagogik. Jag genomförde intervjuerna individuellt och i mindre grupper. De svar som framkom vid intervjuerna synliggjorde två huvudinriktningar bland de intervjuade lärarstudenterna med avseende på fostran, explicit fostran och implicit fostran. Några av de blivande fritidspedagogerna såg inledningsvis sin roll som fostrare som en del av explicit fostran, till exempel när regler utarbetas och när barnen behöver tillrättavisas då regler bryts. Den andra gruppen av lärarstudenter såg sin roll som fostrare på fritidshem som en del av implicit fostran. De såg att implicit fostran äger rum inom fritidsverksamheten vid alla tillfällen då inte explicit fostran förekommer. Resultatet visar fritidspedagogernas oerhört viktiga arbete som förebilder och fostrare för barn på fritidshem, i samarbete med barnens föräldrar. Min handledare, professor Inge Johansson, har varit ett gott stöd för min studie och gett mig många värdefulla synpunkter. Det är en stor förmån att ha en handledare som är en av de ledande forskarna inom fritidshemmens verksamhetsfält. Ett gott stöd har jag även haft av min familj, vilka läst och kommenterat mina texter. Nyckelord Fritidshem, fostran, social fostran, Bourdieu, fält, kapital, praktiskt sinne, habitus</p><p>This study focuses student teachers’ views on the role of leisure time pedagogues in educating children at leisure time centres. The French sociologist Bourdieu and his ideas of socialisation are the main theoretical basis for my study. Bourdieu talks about fields, capital, practical sense and habitus. In the study I also compare Bourdiues ideas with the ideas of other pedagogues, such as Dewey and Säljö, whose works are more concerned with sociocultural education. In order to clarify the idea of educating children at leisure time centres I made interviews with 10 student teachers who are studying to become leisure time pedagogues. I held the interviews in small groups or with one subject at a time. The interviews in the study imply that there are two main ways of educating children among the student teachers; the explicit way of education and the implicit way of education. Some of the prospective leisure time pedagogues initially notice their part in the explicit way of educating children, i.e. when the rules of the leisure time centre are made up and when those rules are broken and they have to reprove the children. The other student teachers recognize the educating of children at the leisure time centre when they look at implicit education. Those prospective leisure time pedagogues find that implicit education is what you continually do at the leisure time centre under the condition that no explicit education takes place. This way of educating children seems to characteristic of leisure time pedagogues who truly engage in their work and take a genuine interest in children. The results indicate that the leisure time pedagogues have an important work to do as trainers for young people. Keywords Leisure time centres, education, social education, Bourdieu, fields, capital, practical sense, habitus</p>
40
Krajisnik, Tijana. "Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders." Doctoral thesis, Uppsala universitet, Medicin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107456.
Full textAbstract:
Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. Patients with chronic kidney disease (CKD) are highly morbid due to Pi retention/hyperphosphatemia and calcitriol deficiency, which lead to elevated serum levels of parathyroid hormone (PTH) and secondary hyperparathyroidism (sHPT). As a response to hyperphosphatemia, CKD patients have also remarkably high serum FGF23 levels, which are associated with cardiovascular risk factors and increased mortality in CKD. The overall aim of this dissertation was to discern a possible role of FGF23 in parathyroid biology. Our in vitro experiments on isolated bovine parathyroid cells demonstrate that FGF23 directly and dose-dependently suppresses the PTH production and secretion, while increasing the expression of the 25-hydroxyvitamin D3-activating enzyme 1α-hydroxylase. We investigated possible expressional changes in the FGF23 receptor co-factor Klotho in hyperparathyroid disorders and found that Klotho expression is decreased or absent and inversely correlated to serum calcium (Ca) in adenomas of primary HPT (pHPT). In the hyperplastic parathyroid glands of sHPT, Klotho expression declines in parallel with the kidney function and correlates with the glomerular filtration rate. Moreover, Klotho expression is suppressed by Ca and FGF23, increased by calcitriol, but unaffected by Pi and PTH in vitro. Finally, we identified a novel missense mutation in the gene encoding GALNT3, which is normally involved in the post-translational glycosylation of FGF23, as the cause of aberrant FGF23 processing in a patient with HHS. In summary, we provide evidence for a novel bone/parathyroid axis in which FGF23 functions as a direct, negative regulator of the PTH production. High extracellular Ca is a major determinant of the Klotho expression in pHPT, whereas the Klotho levels in sHPT may be attributed to a combination of the high FGF23 and Ca, and low calcitriol levels associated with CKD. Hence, the decreased Klotho expression in sHPT could explain the concomitantly high FGF23 and PTH levels, as well as the failure of FGF23 to prevent or mitigate the development of sHPT in CKD.
41
Karlsson, Sofie, and Jessica Sjöstedt. "Det går inte att göra lika, det gör inte det även om man ska. : En kvalitativ studie om etnicitet och handlingsutrymme i familjehemsutredningar." Thesis, Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139452.
Full textAbstract:
Syftet med detta självständiga arbete är att undersöka hur etnicitet tillskrivs betydelse i utredningar avfamiljehem. Vidare vill vi undersöka hur familjehemssekreterarna beskriver sitt handlingsutrymme iutredningsarbetet. Syftet har besvarats med följande frågeställningar; (1) Hur aktualiseras etnicitet vidutredningar av familjehem? (2) Hur beskriver familjehemssekreterare sina erfarenheter avutredningsarbete av familjer med annan etnisk bakgrund än svensk? (3) Vilka utmaningar uppkommervid utredningar av familjer med en annan etnisk bakgrund än svensk? Socialstyrelsen anser att det finnsförbättringsåtgärder i familjehemsutredningar, främst gällande likvärdiga utredningsmodeller, men ävengällande den kompetensbrist som finns i socialt arbete vid bemötandet av utrikesfödda. I Sverige saknastidigare forskning kring familjehemsutredningar och etnicitet, det finns viss internationell forskning somfrämst utgår från adoption. De teoretiska utgångspunkter vi använt oss av är socialkonstruktionism,etnicitet som teoretiskt begrepp samt gräsrotsbyråkrati. Vi har genomfört en kvalitativ studie medsemistrukturerade intervjuer och intervjuat sex familjehemssekreterare och en enhetschef. När vianalyserade materialet kom vi slutligen fram till tre empiriska kategorier; Att behandla alla lika iutredningarna, idealfamilj samt utredningsdilemman. Resultatet visar att etnicitet aktualiseras tidigt iutredningsskedet när familjehemssekreterarna kategoriserar att familjen har en annan etnisk bakgrundän svensk. Efterföljande utredning skiljer sig från en utredning genomförd på en svensk familj, vid dessautredningar används en annan utredningsmodell. Familjehemssekreterarna beskriver och använder sitthandlingsutrymme på olika sätt vilket innebär att det skiljer sig mellan familjehemssekreterarnasutredningar av utrikesfödda familjer. De utmaningar som familjehemssekreterarna står inför ärframförallt likabehandling där organisationen säger att de ska behandla alla lika, medan familjernaförutsätter att de utreds efter sina individuella förutsättningar. En annan svårighet gällernätverksplaceringar där barnets anknytning väger tyngre än nätverkshemmets brister. Detta kan i vissafall bidra till en intressekrock mellan barnhandläggare och familjehemssekreterare därfamiljehemssekreterare får fatta beslut som strider mot riktlinjerna för när en familj ska bli godkänd.
42
Lundgren, Jenny, and Kajsa Trygg. ""Omsorg finns i allt vi gör" : En kvalitativ studie om vilken innebörd förskollärare ger omsorgsbegreppet samt vad de upplever betydelsefullt i omsorgsarbetet i förskolan." Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-42403.
Full textAbstract:
Syftet med studien var att undersöka vilken innebörd förskollärare ger begreppet omsorg i dagens förskola. Studien baseras på en kvalitativ metod med semistrukturerade intervjuer med åtta yrkesverksamma förskollärare. Resultatet visar att förskollärarna gav snarlika innebörder i omsorgsbegreppet. Gemensamt, bland de flesta förskollärarna, är att omsorgsbegreppet verkar beskrivas utifrån ett emotionellt perspektiv där grunden i omsorgsarbetet framställs utifrån en vilja att bry sig om och möta varje barns behov. Förskollärarna uppgav att relationen mellan barn och personal är betydelsefullt i omsorgsarbetet. Resultatet visar även att förskollärarna uppgav att tiden för att utveckla dessa relationer är av betydelse men att tidsaspekten även är ett hinder i omsorgsarbetet. Slutligen uppgav förskollärarna att omsorgsbegreppet sällan tas upp i reflektionssammanhang i arbetslaget. Studiens slutsats var att omsorgsbegreppet behöver analyseras i arbetslaget i syfte att skapa en gemensam förståelse för innebörder i omsorgsarbetet. Slutsatsen var även att tid behövs för att skapa trygga relationer.
43
Forss, Esbjörn, and Viktor Fredbäck. "”Gör om, gör rätt” : En studie som beskriver begreppet ”Gör om, gör rätt” och hur det uppfattas utifrån en grupp värnpliktiga i Försvarsmakten." Thesis, Uppsala University, Department of Education, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8110.
Full text
44
Molander, Jenny. "Att hålla sig strategisk till könsnormer : Barn gör inte som vi säger barn gör som vi gör!" Thesis, Södertörns högskola, Lärarutbildningen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-29062.
Full textAbstract:
The purpose of this study is to examine how genders are made within the gender neutral discourse in the preschools equality treatment area. The study is based on critcal literature studies influed by discourse analysis and hermeneuitcs. It also relies on intervjues with two preschool teachers. The study will examine and answer the following questions: How are genders made within the gender neutral discourse? How is the feminine and masculine problematized in preschool and how is the discourse within gender neutrality linked to norms, power and gender? The theoretical starting point of this study is gender. This starting point also includes norms, power and masculinity, to get a complete understanding of the problem area. The result of the study shows that the ambition to develope a gender natural policy in pre school is a problematic issue because the understanding of the concept neutrality excludes the feminine. Finally with critical eyes against the gender neutral concept my interpretation is that we need to concider the norms to be able to reach equal treatment and gender equality. These unwritten laws that norms produce creates unbalance, power structure and exclusion between genders and individuals. Keywords: Gender, Norm criticism, equal treatment, gender equality, gender neutrality. Nyckelord: Genus, normkritik, likabehandling, jämställdhetsarbete och könsneutralitet.
45
Skogwik, Carl. "”Eftersom vi går på en idrottskola så blir det automatiskttävling i allt vi gör.” : En enkätstudie av gymnasieelever på högskoleförberedande programs upplevelserkring tävlingsmomentet i idrottsundervisningen." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83274.
Full textAbstract:
Skolinspektionens (2018) beskriver hur tävlingsmomentet är ett vanligt förekommande moment som tar stor plats i undervisningen, trots momentets frånvaro i styrdokumenten. Tävling kan enligt tidigare forskning (Stolz, 2014) leda till ett negativt klimat för lärande där elever känner sig utpekade samt utsatta. Syftet med studien är därför att undersöka hur gymnasieelever upplever tävlingsmomentet i undervisningen samt om eventuella skillnader i upplevelser beror på kön eller idrottslig bakgrund. Studien som utförts har ett kvantitativ förhållningssätt, där en enkät har konstruerats och används som datainsamlingsmetod. Enkäten delades ut till 231 elever fördelade på två skolor i sju olika klasser. Av de 231 som fick enkäten var det 221 som valde att fylla i enkäten och gav sitt samtycke till deltagande i studien. Enkäten består framförallt av påståenden som eleverna besvarar med likertskalor, men avslutas också med tre öppna frågor för att få en djupare bild av fenomenet. Resultatet av studien visar att många elever oavsett kön eller idrottslig bakgrund uppskattar tävlingsmomentet och motiveras av att det förekommer i undervisningen. Resultatet visar också att de skillnader som finns verkar bero på kön snarare än om eleverna är idrottsligt aktiva eller inte. Från resultatet går det dra slutsatsen att tävlingsmomentets förekomst i undervisningen kan motiveras av dess popularitet och motivationshöjande effekt. Ytterligare en slutsats för lärare att ta hänsyn till att elever lägger vikt vid att prestera i aktiviter med tävling. Lärare bör se till att eleverna vilja att prestera inte övergår till prestationsångest eller en stress över att behöva prestera.
46
Gottfarb, Micha. "Så gör förmögna." Thesis, Stockholm University, School of Business, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6110.
Full textAbstract:
<p>Historiskt sett har kapitalförvaltning endast varit de rika förunnat, men under de senaste åren har vi sett en ökad rörlighet bland förmögna och nya aktörer vill vara med och slåss om förvaltningen. Numera har också många fler människor tillgång till information och de flesta har direktaccess till kapitalmarknaden. Private Banking är ett begrepp som syftar till en viss typ av behandling för en viss typ av kunder. I Sverige finns det idag cirka 53 000 personer som har mer än 3 miljoner kronor att förvalta. För att utnyttja fördelarna i den nya ekonomin krävs en helt annan typ av engagemang från kunden än vad som förväntas vid traditionell Private Banking. I Sverige har vi först under de senaste åren börjat se tydliga förändringar i beteendet hos denna grupp investerare. Man börjar nu se att kunderna blandar sig i investeringsbesluten mer än tidigare och det är först nu som gruppen har börjat röra på sig. Nya aktörer attraherar kunderna, vilka nu har full insyn i förvaltningen. Frågan är vad det är som driver den enskilde individen i valet av firma? Vad vill en modern miljonär ha? För att verkligen lära känna de utvalda segmenten inom kundgruppen Private Banking och för att kunna ta reda på deras specifika behov har ett trettiotal befintliga Private Bankingkunder kunder intervjuats. Resultatet av undersökningen har visat att Private Banking kunderna tenderar att vilja lära sig nya saker för att sedan själva omsätta kunskaperna i verkligheten. Produktutbudet och priset är en väldigt viktig faktor, men även tillgången till relevant information och utbildningar i allt från kunskap om finansiella instrument till skatteplanering och att lära sig analysera ett specifikt bolag.</p>
47
Hedin, Magnus. "Vad gör kyrkoherden?" Thesis, Uppsala University, Department of Education, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107461.
Full text
48
Ljunggren, Annette. "Gör inte så." Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-29193.
Full textAbstract:
Annette Ljunggren, 2016Titel: ”Gör inte så”Min studies syfte är att undersöka barns uppfattningar om förskolans måltider utifrån barns perspektiv och hur barnen görs delaktiga. För att nå mitt syfte formulerade jag tre frågor. Dessa frågor är hur barnens handlingar och åsikter tas tillvara på. Barnens möjlighet till att få vara involverade i måltiden och hur normer om barn framstår och blir synliga inom måltiden i förskolan. I min studie använde jag mig av kvalitativ forskning och en mini etnografisk studie som metod. Under studien var jag deltagande observatör vid måltiden och kompletterade genom att filma. Efter observationerna antecknade jag ner sådant som jag tänkte på utifrån det jag observerade vid måltiden. Mitt analysredskap är postmodern teori som ifrågasätter de förgivettagna. Då min studies syfte är att få fram barns perspektiv vid måltiden blev denna teori väl passande för min studie. Resultatet av min analys visar på att barns perspektiv inte alltid blir så uppmärksammat i den pedagogiska måltiden. Normer om barns förhållningsätt och uppförande har en stark påverkan. Barns perspektiv blir inte synliggjort i den mån det ska i enlighet med styrdokumenten i förskolan. Nyckelord: barns perspektiv, postmodern teori, normer och maktrelationer.
49
Boutz-, Laneborg Stina, and Helena Haglöv. "Vad gör att elever går till skolan? : En kvantitativ enkätstudie med utgångspunkt i ett salutogent perspektiv kring vad elever anser är betydelsfullt för dem i skolan." Thesis, Stockholms universitet, Specialpedagogiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-194099.
Full text
50
Polfors, Madelene. "Brottsmedlingen på utdöende. Gör om gör rätt... Är nationell samordning brottsmedlingens räddning?" Thesis, Umeå universitet, Juridiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148873.
Full text