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Journal articles on the topic 'Giant congenital melanocytic nevus'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Viana, Ana Carolina Leite, Bernardo Gontijo, and Flávia Vasques Bittencourt. "Giant congenital melanocytic nevus." Anais Brasileiros de Dermatologia 88, no. 6 (2013): 863–78. http://dx.doi.org/10.1590/abd1806-4841.20132233.

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Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter ≥ 20 cm in adulthood. Its incidence is estimated in <1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcat

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2

Hanae, BOUZIDI. "Woman with Giant Lesion in the Trunk." International Journal of Dermatology and Clinical Research 1, no. 1 (2015): 007–8. https://doi.org/10.17352/2455-8605.000002.

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The congenital melanocytic nevus is a type of melanocytic nevus found in infants at birth. This type of birthmark occurs in an estimated 1% of infants worldwide. It may be divided into the Small, mediumsize congenital nevocytic nevus and giant congenital melanocytic nevus also known as “Bathing trunk nevus,”. We report a case in a 42-year-old woman.

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3

Tyagi, Arty, Bipin Kumar, and Mani Kant Kumar. "Giant congenital melanocytic nevus: a rare case report." International Journal of Contemporary Pediatrics 7, no. 11 (2020): 2236. http://dx.doi.org/10.18203/2349-3291.ijcp20204407.

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Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present a birth. Its incidence is estimated in <1 in 20,000 newborns. Despite its rarity, this lesion is important because it may be associate with severe complications such as malignant melanoma and may also cause neurological deficit including neurocutaneous melanocytosis. Giant congenital melanocytic nevus generally present as a brown lesion with flat or mammilated surface, well-demarcated borders and hypertrichiosis. Congenital melanocytic nevus is primarily a clinical diagnosis. Recently, we encountered a 3 d

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4

Rasmussen, Bo Sonnich, Trine Foged Henriksen, Stig-Frederik Trojahn Kølle, and Grethe Schmidt. "Giant Congenital Melanocytic Nevus." Annals of Plastic Surgery 74, no. 2 (2015): 223–29. http://dx.doi.org/10.1097/sap.0b013e3182920c3d.

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5

Purushothaman, Suruthi, and Sushmitha Dharanisankar. "Giant congenital melanocytic nevus." Cosmoderma 3 (February 28, 2023): 43. http://dx.doi.org/10.25259/csdm_17_2023.

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6

Sarala, K., V. Ramya, and N. Radhika. "Congenital giant melanocytic nevus." Journal of the Pediatrics Association of India 3, no. 4 (2014): 190. http://dx.doi.org/10.4103/2667-3592.300970.

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7

Bajaj, Mohit, Swati Mahajan, and Saurabh Sharma. "Giant Congenital Melanocytic Nevus in Newborn-Case Report." Asian Pacific Journal of Health Sciences 6, no. 2 (2019): 142–44. http://dx.doi.org/10.21276/apjhs.2019.6.2.20.

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8

Silveira, Marina Leite da, Flávia Regina Ferreira, Marcia Lanzoni Alvarenga, and Samuel Henrique Mandelbaum. "Association of giant congenital melanocytic nevus, halo nevus and vitiligo in a 75-year-old patient." Anais Brasileiros de Dermatologia 87, no. 2 (2012): 288–91. http://dx.doi.org/10.1590/s0365-05962012000200015.

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A giant congenital melanocytic nevus represents a rare condition. The halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of halo nevus and giant congenital melanocytic nevus is rare and the association of both with vitiligo even more rare. A 75-yearold woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic halo of onset three years ago. The histological features were consistent with congenital melanocytic nevus and halo nevus, respectively.

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9

Margulis, Alexander, Benjamin Z. Koplewitz, Alexander Maly, et al. "Combination of preoperative embolization and surgery in the treatment of a giant congenital neuroid nevus of the forehead and scalp in a child." Journal of Neurosurgery: Pediatrics 3, no. 3 (2009): 215–19. http://dx.doi.org/10.3171/2008.11.peds08146.

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Congenital melanocytic nevi of neuroectodermal origin are composed primarily of melanocytes and occasional neural elements. A subset of large/giant congenital melanocytic nevi is characterized by neuroidal differentiation resembling the histological pattern of neurofibroma (neuroid congenital melanocytic nevi). The authors report the case of a male infant born with a neuroid congenital melanocytic nevus presenting as a large mass covering extensive portions of his scalp and forehead. The atypical feeding arteries to the nevus were larger in diameter then the patient's internal carotid arteries

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10

Wadhwani, Meenakshi, Rachna Meel, and Neelam Pushker. "Giant congenital facial melanocytic nevus." Oman Journal of Ophthalmology 11, no. 3 (2018): 265. http://dx.doi.org/10.4103/ojo.ojo_216_2017.

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11

Cruz, Oscar A. "Periorbital Giant Congenital Melanocytic Nevus." Archives of Ophthalmology 110, no. 4 (1992): 562. http://dx.doi.org/10.1001/archopht.1992.01080160140052.

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12

Agarwal, Apoorva, Neeraj Dhameja, and Amrita Ghosh Kar. "Giant congenital melanocytic nevus associated with lipoma in an Indian man." BMJ Case Reports 12, no. 7 (2019): e228688. http://dx.doi.org/10.1136/bcr-2018-228688.

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Congenital melanocytic nevus is a inborn melanocytic proliferation either present since birth or soon afterward and shows characteristic histopathological features comprising proliferation of benign melanocytes and extension of nevus cells into the deep reticular dermis and subcutis. We report the case of a 35-year-old male patient who presented with a progressively enlarging soft tissue mass in bilateral flank region. High-resolution ultrasound imaging showed multiple lipomatous masses within the soft tissues on the either flank region. Subsequent excision of the soft tissue mass showed a wel

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13

Hashmi, Ghulam S., Syed S. Ahmed, and Shahla Khan. "Congenital Giant Melanocytic Nevi." Rare Tumors 1, no. 1 (2009): 1–3. http://dx.doi.org/10.4081/rt.2009.e9.

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Nevi are common skin tumors caused by abnormal overgrowth of cells from the epidermal and dermal layers of the skin. Most nevi are benign, but some pre-cancerous nevi must be monitored or removed. The giant congenital nevus is greater than 10 cm in size, pigmented and often hairy. Between 4% and 6% of these lesions will develop into a malignant melanoma. Since approximately 50% of the melanoma develop by the age of two, and 80% by the age of seven, early removal is recommended. The objective of this paper is to present a unique case of giant nevi and their surgical management.

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14

Mariel, Sánchez Guevara, Hidalgo Ostoa Miriam, García Campos María Elena, and Soto Piña Pamela Iiliana. "Giant congenital melanocytic nevus in an 8-year-old female: a case report." International Journal of Research in Dermatology 10, no. 5 (2024): 274–76. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20242360.

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Giant congenital melanocytic nevus are melanocytic lesions secondary to abnormal melanoblast migration during the embryogenesis. The incidence reported is in 1 case for every 20 000 newborns and it is present since birth. The importance of its detection relies on the associated complications, such as melanoma development or neurocutaneous melanosis, as well as the psychological and social impact they generate; patients will require a long-term multidisciplinary attention. There is no elective treatment, management is still controversial, it must be individualized according to the characteristi

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15

Green, Jackson, Jessica Nye, Kelly Turner, et al. "Malignant Melanoma within a Giant Congenital Melanocytic Nevus in a Pediatric Patient." SKIN The Journal of Cutaneous Medicine 7, no. 1 (2023): 608–11. http://dx.doi.org/10.25251/skin.7.1.9.

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While giant congenital melanocytic nevi are rare lesions in the pediatric population, malignant transformation within these lesions remains even more rare. A 22-month-old male patient developed a 6.5 mm Clark’s Level IV melanoma within a giant congenital nevus with an activating NRAS variant. The need for frequent surveillance and screening of giant congenital melanocytic nevi is essential to identify early signs of melanoma, even in the pediatric population.

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16

Tchernev, Georgi, James W. Patterson, Ilko Bakardzhiev, et al. "Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus." Open Access Macedonian Journal of Medical Sciences 5, no. 4 (2017): 533–34. http://dx.doi.org/10.3889/oamjms.2017.077.

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A 61-year-old woman, with a lifelong history of a giant congenital melanocytic nevus in the occipital region with secondary development of giant melanoma is presented. Surgical excision was performed, and the histopathological evaluation confirmed the diagnosis of Giant Malignant Melanoma (GMM) with a maximum tumour thickness of 16 mm. Nowadays, there is tremendous uncertainty regarding how giant congenital melanocytic nevi (GCMN) should be treated. The standard approach to patients with late onset giant congenital melanocytic nevi (GCMN is based on two main considerations: (1) obtain an accep

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17

Siddhi, Patel, Nitinkumar Soni* Dhruv, Sakshi Tusharbhai Kapadia, and Piyal Hiteshkumar Patel. "INTERSECTING CONDITIONS: NEUROFIBROMATOSIS WITH NEUROCUTANEOUS MELANOSIS, AND ITS MANIFESTATIONS – A REVIEW." World Journal of Pharmaceutical Science and Research 3 (October 1, 2024): 58–62. https://doi.org/10.5281/zenodo.13869228.

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Neurofibromatosis, Neurocutaneous Melanosis, and Giant Congenital Melanocytic Nevus are rare and complex conditions that often present significant diagnostic and therapeutic challenges. Neurofibromatosis (NF) is a genetic disorder characterized by the development of multiple benign tumors of the nerves and skin, as well as other abnormalities such as bone deformities and learning disabilities. Neurocutaneous Melanosis (NCM) is a rare congenital condition marked by the presence of melanocytic nevi in the skin and melanocytic tumors in the central nervous system. Giant Congenital Melanocytic Nev

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18

Mir, Adnan, Nnenna G. Agim, Alex A. Kane, Shellie C. Josephs, Jason Y. Park, and Kathleen Ludwig. "Giant Congenital Melanocytic Nevus Treated With Trametinib." Pediatrics 143, no. 3 (2019): e20182469. http://dx.doi.org/10.1542/peds.2018-2469.

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19

Chaoui, Rhizlane, Selma El Kadiri, and Kaoutar Achehboune. "Giant congenital melanocytic nevus associated with lipoma." Our Dermatology Online 11, e (2020): e7.1-e7.3. http://dx.doi.org/10.7241/ourd.2020e.7.

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20

El Ahmed, Husein Husein, and Jose Carlos Ruiz Carrascosa. "Giant congenital melanocytic nevus on the back." Our Dermatology Online 3, no. 2 (2012): 138–39. http://dx.doi.org/10.7241/ourd.20122.31.

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21

Petit, Lauren, and Tyson Meaux. "Giant congenital melanocytic nevus with neurocutaneous melanosis." Our Dermatology Online 10, no. 1 (2019): 51–52. http://dx.doi.org/10.7241/ourd.20191.12.

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22

de Blacam, Catherine, Michael Mc Dermott, and David O'Donovan. "Giant Congenital Melanocytic Nevus with Cartilaginous Differentiation." Pediatric Dermatology 30, no. 4 (2012): 501–2. http://dx.doi.org/10.1111/pde.12068.

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23

Saribulan, Marina, and Ennesta Asri. "A Rare Case of Giant Congenital Melanocytic Nevi: A Case Report." Bioscientia Medicina : Journal of Biomedicine and Translational Research 7, no. 1 (2023): 3000–3005. http://dx.doi.org/10.37275/bsm.v7i1.750.

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Background: Giant congenital melanocytic nevi are often characterised as melanocytic lesions present at birth. It is thought that it affects 1 in 20,000 births. The lesion is significant because it may be associated with serious consequences, such as malignant melanoma, and may also result in neurological deficits, such as neurocutaneous melanocytosis. This study aimed to present the case of giant congenital melanocytic nevus as a rare case. Case presentation: This study reported a 14-year-old female reported with large blackish rough spots on the trunk that were neither itchy or painful

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24

Patel, Shruti, and Naveen Kumar. "Cerebriform congenital melanocytic nevus of scalp and its management using tissue expansion." Journal of Skin and Sexually Transmitted Diseases 4 (October 27, 2021): 76–78. http://dx.doi.org/10.25259/jsstd_68_2021.

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Congenital melanocytic nevi are benign proliferations of cutaneous nevomelanocytes. Usually, they manifest at birth or become apparent within the first few years of life. The nevi show variable surface morphology (papular, rugose, verrucous, or cerebriform). Congenital melanocytic nevus showing cerebriform morphology is a rarity. Early diagnosis and surgical excision are usually recommended in congenital melanocytic nevus to prevent the future risk of malignant transformation which is higher in larger lesions, especially in giant forms (>20 cm in size). An excision of the lesion also helps

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25

Mikóczi, Márió, and Béla Novoth. "Aspects of removal of large and giant nevi in childhood." Bőrgyógyászati és Venerológiai Szemle 99, no. 5 (2023): 356–64. http://dx.doi.org/10.7188/bvsz.2023.99.5.4.

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The removal of common nevi is necessary only in case of irritation, changes causing complaints, or dermatological recommendations, in addition to regular inspections. In case of the need for surgical removal of special birthmarks (e.g. Spitz nevus, Halo nevus, etc.), a dermatological examination and recommendation are also essential. Congenital melanocytic nevus is a special entity. In 1-3% of newborn cases we encounter the small (<1.5 cm) congenital melanocytic nevus, and less often a giant (≥40 cm) nevus. The number, localization and morphology of congenital melanocytic nevi are more impo

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26

Keen, AbidAbid, and Iffat Hassan. "Giant congenital melanocytic nevus (bathing trunk nevus) in a neonate." Indian Journal of Paediatric Dermatology 15, no. 1 (2014): 53. http://dx.doi.org/10.4103/2319-7250.131846.

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27

Balachandrudu, Jonnalagadda, and Beri Udaya Kumar. "GIANT CONGENITAL MELANOCYTIC NEVUS (BATHING TRUNK NEVUS)- A CASE STUDY." Journal of Evolution of Medical and Dental Sciences 7, no. 13 (2018): 1681–83. http://dx.doi.org/10.14260/jemds/2018/380.

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28

Lin, Weizhao, Yixuan Zhou, and Ruiman Li. "Giant Congenital Melanocytic Nevus in a Chinese Newborn." Clinical, Cosmetic and Investigational Dermatology Volume 14 (May 2021): 557–59. http://dx.doi.org/10.2147/ccid.s308725.

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29

Aarif Syed, M. M., and DwarikaPrasad Shrestha. "Giant congenital melanocytic nevus with neurofibroma-like papules." Pigment International 6, no. 2 (2019): 113. http://dx.doi.org/10.4103/pigmentinternational.pigmentinternational_25_18.

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30

Wang, Xin, Peng Luo, Harumi Hanazawa, et al. "Giant congenital melanocytic nevus associated with cerebellar astrocytoma." European Journal of Dermatology 28, no. 2 (2018): 254–55. http://dx.doi.org/10.1684/ejd.2018.3218.

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31

Alipour, Marzieh, Khalil Khashei Varnamkhasti, Marzieh Eslami Moghaddam, and Masumeh Panahi. "A Case Report of Giant Congenital Melanocytic Nevus." Avicenna Journal of Clinical Medicine 28, no. 1 (2021): 66–69. http://dx.doi.org/10.52547/ajcm.28.1.66.

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32

Gonzalez Ruiz, Yurema, and Juan Carlos López Gutiérrez. "Multiple Tissue Expansion for Giant Congenital Melanocytic Nevus." Annals of Plastic Surgery 79, no. 6 (2017): e37-e40. http://dx.doi.org/10.1097/sap.0000000000001215.

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33

Hogan, Daniel J., Fergus Murphy, and Ronald M. Bremner. "Spontaneous Resolution of a Giant Congenital Melanocytic Nevus." Pediatric Dermatology 5, no. 3 (1988): 170–72. http://dx.doi.org/10.1111/j.1525-1470.1988.tb01164.x.

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34

Martínez-Barba, Enrique, Luis Alberto Polo-García, Belen Ferri-Ñíguez, José Antonio Ruiz-Maciá, Heinz Kutzner, and Luis Requena. "Congenital Giant Melanocytic Nevus With Pigmented Epithelioid Cells." American Journal of Dermatopathology 24, no. 1 (2002): 30–35. http://dx.doi.org/10.1097/00000372-200202000-00006.

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35

Yang, Tianyou, Yan Zou, Jiahao Li, et al. "Infantile fibrosarcoma associated with giant congenital melanocytic nevus." Journal of Pediatric Surgery Case Reports 29 (February 2018): 30–31. http://dx.doi.org/10.1016/j.epsc.2017.10.011.

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36

Christman, Mitalee P., Jennifer K. Kerner, Carol Cheng, et al. "Rhabdomyosarcoma Arising in a Giant Congenital Melanocytic Nevus." Pediatric Dermatology 31, no. 5 (2014): 584–87. http://dx.doi.org/10.1111/pde.12359.

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37

Schambach, Marie A., and Jose López. "Giant Congenital Melanocytic Nevus Correction: A Case Report." International Society of Hair Restoration Surgery 33, no. 3 (2023): 85–92. http://dx.doi.org/10.33589/33.3.85.

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38

Applebaum, Sarah A., Joshua P. Weissman, Emily S. Chwa, Stuti P. Garg, and Arun K. Gosain. "Giant Congenital Melanocytic Nevi of the Head and Neck: Clinical Update and Advances in Treatment." FACE 3, no. 1 (2022): 107–15. http://dx.doi.org/10.1177/27325016221077600.

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Introduction: Giant congenital melanocytic nevi are rare lesions of various size, shape, color, and location with potential complications including malignant and neurocutaneous melanoma. Here we discuss the etiology and epidemiology of giant congenital melanocytic nevi, the indications and options for treatment, and current data regarding outcomes, as well as our preferred approach to patient management. Methods: Full text case reports, retrospective studies, prospective studies, clinical trials, and review articles regarding giant congenital melanocytic nevi in English were included in this a

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39

Filippova, O. V., D. V. Chesanov, N. V. Roshchina, Ya N. Proshchenko, and E. N. Provorova. "Invasive melanocytic nevus: a case report." Plastic Surgery and Aesthetic Medicine, no. 1 (March 5, 2025): 135. https://doi.org/10.17116/plast.hirurgia2025011135.

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A rare harmful case of invasive melanocytic nevus in a child is described. In accordance with guidelines, independent method, histological and IHC analysis, MRI, consultations with neurologist and neurosurgeon are recommended. Giant congenital melanocytic nevi are rare. In some cases, such nevi may not just be an isolated lesion, but symptom of phacomatosis (neurocutaneous melanosis). Differential diagnosis is usually difficult due to gradual progression of disease. Primary diagnostic screening usually includes MRI of the central nervous system, histological examination of nevi and consultatio

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40

Das, Pankaj, Biju Vasudevan, Ahmed Waheed Kashif, et al. "A Rare Case of Nevus Spilus Type of Giant Congenital Melanocytic Nevus with Classic Proliferative Nodules, Intraparenchymal Melanosis, and Seizures." Indian Journal of Paediatric Dermatology 25, no. 4 (2024): 325–28. https://doi.org/10.4103/ijpd.ijpd_91_24.

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Abstract Congenital melanocytic nevi, as the name suggests, are present since birth. They are called giant congenital melanocytic nevus (GCMN) when the size exceeds >20 cm in diameter. Due to its unsightly appearance, there is major psychosocial impact on the patient and the family. GCMN in due course of time may give rise to malignant melanoma not only in the GCMN but also in the leptomeninges. Clinical variants of GCMN include nevus spilus type, which is a rare variant. In addition to that with time, GCMN may continue to be affected with benign nodules. We present a rare case of a nevus s

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41

Araújo, Catarina, Cristina Resende, Francisco Pardal, and Celeste Brito. "Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis." Case Reports in Medicine 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/545603.

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Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis.Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examinat

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42

Singh, Om Prakash, Vikas Kumar, and Rahul Kumar. "Giant congenital melanocytic nevi (garment variety): a case report." International Journal of Contemporary Pediatrics 8, no. 9 (2021): 1625. http://dx.doi.org/10.18203/2349-3291.ijcp20213333.

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Giant congenital melanocytic nevi (GCMN) are large brown-to-black skin lesions caused due to genetic mutations which lead to defective proliferation, differentiation and migration of melanoblasts which are precursor cells of melanocytes. There is a mutation in the NRAS gene causing abnormal proliferation of embryonic melanoblasts. Congenital melanocytic nevus is primarily a clinical diagnosis. The malignant melanoma and neurocutaneous melanosis are the two major complications associated with GCMN. The risk of transformation of GCMN to malignant melanoma varies between 0 and 3.8%. About 1% of l

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43

Gambichler, Thilo, Kathrin Noldes, Yousef Arafat, Matthias Neid, Arno Rütten, and Stefanie Boms. "Rapid Melanoma Death of an Adult Male with Congenital Bathing Trunk Nevus despite Initiation of Combination Immunotherapy." Dermato 3, no. 1 (2023): 51–55. http://dx.doi.org/10.3390/dermato3010004.

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44

Prose, Neil S., Teresita A. Laude, Edward R. Heilman, and Charles Coren. "Congenital Malignant Melanoma." Pediatrics 79, no. 6 (1987): 967–70. http://dx.doi.org/10.1542/peds.79.6.967.

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A 6-week-old girl with congenital melanoma of the skin is reported and the literature is reviewed. We believe this to be the first case of congenital melanoma in a black infant who had no underlying giant melanocytic nevus. Because of the significant relationship between the early treatment and prognosis of malignant melanoma, we wish to alert pediatric clinicians to the existence of this rare congenital neoplasm.

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45

Tamer, Funda, and Mehmet Eren Yuksel. "Giant congenital melanocytic nevus coexisting with an asymmetric posture." Our Dermatology Online 9, no. 1 (2018): 68–70. http://dx.doi.org/10.7241/ourd.20181.19.

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46

Berman, Brian, Annette M. Shaieb, Dennis S. France, and Douglas D. Altchek. "Halo giant congenital melanocytic nevus: In vitro immunologic studies." Journal of the American Academy of Dermatology 19, no. 5 (1988): 954–60. http://dx.doi.org/10.1016/s0190-9622(88)70258-3.

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47

Cai, C., Q. Zhang, W. Yang, and C. Shen. "Giant Congenital Melanocytic Nevus Coexistent with Chiari II Malformation." Neuropediatrics 39, no. 05 (2008): 272–75. http://dx.doi.org/10.1055/s-0028-1104576.

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48

Bajwa, Nadia M., Eliot N. Mostow, and Richard M. Schwartz. "Rapidly Expanding Lesion in a Giant Congenital Melanocytic Nevus." Clinical Pediatrics 42, no. 5 (2003): 455–58. http://dx.doi.org/10.1177/000992280304200513.

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49

Kim, S. J., J. H. Kim, B. Son, and C. Yoo. "A Giant Congenital Melanocytic Nevus Associated with Neurocutaneous Melanosis." Clinical Neuroradiology 24, no. 2 (2013): 177–84. http://dx.doi.org/10.1007/s00062-013-0217-y.

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50

Frigon, Chantal, and Joëlle Desparmet. "Ondansetron Treatment in a Child Presenting with Chronic Intractable Pruritus." Pain Research and Management 11, no. 4 (2006): 245–47. http://dx.doi.org/10.1155/2006/873870.

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The case of a seven-year-old boy with chronic pruritus secondary to a giant congenital melanocytic nevus is presented. The pruritus did not respond to conventional antipruritic drug treatment, but responded to ondansetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors.

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