Log in

Relevant bibliographies by topics / Gilbreth / Journal articles

To see the other types of publications on this topic, follow the link: Gilbreth.

Journal articles on the topic 'Gilbreth'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Gilbreth.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Gibson, Jane Whitney, Jack Deem, Jacqueline E. Einstein, and John H. Humphreys. "Applying a critical biography perspective to the work of Frank Gilbreth." Journal of Management History 22, no. 4 (September 12, 2016): 413–36. http://dx.doi.org/10.1108/jmh-03-2016-0017.

Full text

Abstract:

Purpose The purpose of this study is to examine the life and work of Frank Gilbreth using a critical biographical approach to draw connections between his life experiences and the major contributions he made to management history. Design/methodology/approach The research design is critical biography. First, a biography is provided that reveals critical incidents from his childhood, his early career before marriage, his life after his marriage and his key personality traits. Gilbreth’s major contributions to management thought are then considered in context of his biography. Findings Although Frank Gilbreth is recalled for his contributions to management history through his work in advancing efficiency through motion studies, he should likewise be credited for his foresight of management theories related to the human element in organizations. The major influences on Gilbreth’s career include Lillian Gilbreth and Frederick Taylor. Research limitations/implications A limitation of critical biography is that researchers cannot address causality but, rather, are focused on drawing connections between life experiences and significant accomplishments. Originality/value Critical biography can illuminate theory and practice by providing greater clarity by examining concepts in depth and in context. The authors situate Frank Gilbreth’s work in the context of his lived experiences.

APA, Harvard, Vancouver, ISO, and other styles

2

Gibson, Jane Whitney, Russell W. Clayton, Jack Deem, Jacqueline E. Einstein, and Erin L. Henry. "Viewing the work of Lillian M. Gilbreth through the lens of critical biography." Journal of Management History 21, no. 3 (June 8, 2015): 288–308. http://dx.doi.org/10.1108/jmh-01-2014-0014.

Full text

Abstract:

Purpose The purpose of this paper is to examine the significant contributions of Lillian M. Gilbreth through the lens of critical biography to put her work in the context of her life events, her key roles, the turning points in her life and the societal context within which her contributions to management thought were made. Design/methodology/approach Critical biography examines the interaction of a person’s life events with the social, economic and political contexts surrounding his or her life and draws inferences as to why the person made specific decisions and contributions. Findings Key contributions to management thought made by Lillian M. Gilbreth are linked to her biographical events, including the multiple roles she played as daughter, student, wife, mother, author, engineer, psychologist, breadwinner, domestic scientist and teacher. Various turning points in her life are identified, including being allowed to go to college, taking her first psychology course, marrying Frank Gilbreth, publishing Fatigue Studies and Frank’s death. Key societal factors that influenced Gilbreth’s contributions were the growing interest in scientific management, the status of women and the increased interest in domestic science. Research limitations/implications The qualitative technique of critical biography is demonstrated as a useful methodology for examining individual contributions to management history. The authors acknowledge the limitation of subjective interpretation. Practical implications The reasons behind Lillian Gilbreth’s contributions, which were considered a precursor to the human relations era, are extrapolated from this research. Social implications The influence of social context is examined, as it pertains to the life and work of Lillian Gilbreth. Originality/value This paper provides a critical biography of Lillian M. Gilbreth and her work within the context of her life and times.

APA, Harvard, Vancouver, ISO, and other styles

3

Gainty, Caitjan. "“Going After the High-Brows”: Frank Gilbreth and the Surgical Subject, 1912–1917." Representations 118, no. 1 (2012): 1–27. http://dx.doi.org/10.1525/rep.2012.118.1.1.

Full text

Abstract:

This article offers a close examination of the early twentieth-century studies of surgical motion conducted by Frank Gilbreth, the celebrated industrial efficiency expert. The willingness of surgeons to submit to Gilbreth's studies challenges conventional historical narratives, which have read these studies primarily as examples of the individual-effacing effects of technocracy. Through an exploration of the multiple motivations that brought surgeons and Gilbreth together, the article raises new interpretive possibilities for the study of American medicine, and also of industrial work and American culture in this period.

APA, Harvard, Vancouver, ISO, and other styles

4

CORWIN, SHARON. "Picturing Efficiency: Precisionism, Scientific Management, and the Effacement of Labor." Representations 84, no. 1 (November 1, 2003): 139–65. http://dx.doi.org/10.1525/rep.2003.84.1.139.

Full text

Abstract:

ABSTRACT In the early decades of the twentieth century, the pursuit of efficiency came to dominate instances of industrial and artistic production: the engineering consultants Frank and Lillian Gilbreth attempted to visualize a language of minimal waste, while Precisionist art achieved its own aesthetic of efficiency. This essay examines the Precisionist project alongside the discourses of the rationalized factory and suggests a relationship between the formal economy of Precisionism and the rhetoric of scientific management. For Precisionist art and the Gilbreths' time-motion studies, the representation of efficiency ultimately entailed the elision of artist and worker as producers of labor.

APA, Harvard, Vancouver, ISO, and other styles

5

Proctor, Robert W., and Sung-Hee Kim. "100 Years of Human Factors/Ergonomics at Purdue University." Ergonomics in Design: The Quarterly of Human Factors Applications 24, no. 1 (January 2016): 31–34. http://dx.doi.org/10.1177/1064804615572629.

Full text

Abstract:

Human factors/ergonomics (HF/E) has a 100-year history at Purdue University. Frank and Lillian Gilbreth exerted considerable influence on the development of HF/E at Purdue during its first 50 years. Their interdisciplinary approach is evident in the programs of the School of Industrial Engineering and the Department of Psychological Sciences as well as in the many individuals in other departments who have interests in HF/E. Although there has been a shift toward cognitive ergonomics in the past 50 years, the interdisciplinary legacy of the Gilbreths continues to be relevant to research, education, and application in HF/E in the 21st century.

APA, Harvard, Vancouver, ISO, and other styles

6

Stiegler, Bernd. "Wahrheit und visuelle Normalisierung." Zeitschrift für Kulturphilosophie 2014, no. 2 (2014): 279–94. http://dx.doi.org/10.28937/1000106680.

Full text

Abstract:

Three examples try to give an historical overview of strategies of visual normalization. Duchenne de Boulogne, Francis Galton and the taylorist procedures of Frank Bunker Gilbreth are conceived as strategies to transform the human face in practices of truth and knowledge.

APA, Harvard, Vancouver, ISO, and other styles

7

Li, Lianjun, Yizhe Zhang, Michael Ripperger, Jorge Nicho, Malathi Veeraraghavan, and Andrea Fumagalli. "Autonomous Object Pick-and-Sort Procedure for Industrial Robotics Application." International Journal of Semantic Computing 13, no. 02 (June 2019): 161–83. http://dx.doi.org/10.1142/s1793351x19400075.

Full text

Abstract:

This paper describes an industrial robotics application, named Gilbreth, for autonomously picking up objects of different types from a moving conveyor belt and sorting the objects into bins according to their type. The environment, which consists of a moving conveyor belt, a break beam sensor, a 3D camera Kinect sensor, a UR10 industrial robot arm with a vacuum gripper, and different object types such as pulleys, disks, gears, and piston rods, is inspired by the NIST ARIAC competition. A first version of the Gilbreth application is implemented leveraging a number of Robot Operating System (ROS) and ROS-Industrial (ROS-I) packages. The Gazebo package is used to simulate the environment, and six external ROS nodes have been implemented to execute the required functions. Experimental measurements of CPU usage and processing times of the ROS nodes are discussed. In particular, the object recognition ROS package requires the highest processing times and offers an opportunity for designing an iterative method with the aim to fasten completion time. Its processing time is found to be on par with the time required by the robot arm to execute its movement between four poses: pick approach, pick, pick retreat and place.

APA, Harvard, Vancouver, ISO, and other styles

8

Gotcher, J. Michael. "Assisting the Handicapped: The Efforts of Frank and Lillian Gilbreth." Academy of Management Proceedings 1989, no. 1 (August 1989): 143–46. http://dx.doi.org/10.5465/ambpp.1989.4980608.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Towill, Denis R. "Frank Gilbreth and health care delivery method study driven learning." International Journal of Health Care Quality Assurance 22, no. 4 (June 12, 2009): 417–40. http://dx.doi.org/10.1108/09526860910964861.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Baumgart, A., and D. Neuhauser. "Frank and Lillian Gilbreth: scientific management in the operating room." Quality and Safety in Health Care 18, no. 5 (October 1, 2009): 413–15. http://dx.doi.org/10.1136/qshc.2009.032409.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Graham, Laurel. "Lillian Gilbreth and the mental revolution at Macy’s, 1925‐1928." Journal of Management History (Archive) 6, no. 7 (November 2000): 285–305. http://dx.doi.org/10.1108/13552520010359306.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Gibson, Jane Whitney, Jack W. Deem, Jacqueline Einstein, and John Humphreys. "Applying a Critical Biography Perspective to the Work of Frank Gilbreth." Academy of Management Proceedings 2016, no. 1 (January 2016): 10507. http://dx.doi.org/10.5465/ambpp.2016.10507abstract.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Gotcher, J. Micheal. "Assisting the Handicapped: The Pioneering Efforts of Frank and Lillian Gilbreth." Journal of Management 18, no. 1 (March 1992): 5–13. http://dx.doi.org/10.1177/014920639201800101.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Bedeian, Arthur G. "Frank B. Gilbreth, Walter C. Camp and the World of Sports." Management & Organizational History 7, no. 4 (November 2012): 319–35. http://dx.doi.org/10.1177/1744935912457619.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Cannonier, Nicole. "Industrial Safety: Contributions of Frank and Lillian Gilbreth and Hugo Münsterberg." Academy of Management Proceedings 2012, no. 1 (July 2012): 15847. http://dx.doi.org/10.5465/ambpp.2012.15847abstract.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Pokorny, Rita. "Taylor – Gilbreth – Ford aus der Sicht der Rationalisierungsexpertin Irene Witte (1894-1976)." Technikgeschichte 70, no. 3 (2003): 153–84. http://dx.doi.org/10.5771/0040-117x-2003-3-153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Sungsoo Song. "Searching for a Woman Engineer in History: The Case of Lillian Gilbreth." Journal of Engineering Education Research 17, no. 3 (May 2014): 69–76. http://dx.doi.org/10.18108/jeer.2014.17.3.69.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sherry E. Sullivan. "Management's Unsung Theorist: An Examination of the Works of Lillian M. Gilbreth." Biography 18, no. 1 (1995): 31–41. http://dx.doi.org/10.1353/bio.2010.0256.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Caudill, Helene L., and Constance D. Porter. "An Historical Perspective of Reward Systems: Lessons Learned from the Scientific Management Era." International Journal of Human Resource Studies 4, no. 4 (December 1, 2014): 127. http://dx.doi.org/10.5296/ijhrs.v4i4.6605.

Full text

Abstract:

This paper reveals how similar the reward systems prevalent during the scientific management era are to the rewards systems in use today. Systems popular today, such as profit sharing, gain sharing, skill/knowledge-based pay, merit-based pay/pay for performance, and variable-based pay, were also advocated during the reign of scientific management. The ideas expressed by several key scientific management contributors, including Frederick W. Taylor, Henry L. Gantt, Harrington Emerson, and Frank B and Lillian M. Gilbreth, are detailed. These ideas are compared and contrasted with existing reward systems and their underlying premises. In addition, the lessons learned from the scientific management era as they relate to reward system philosophies of today are presented.

APA, Harvard, Vancouver, ISO, and other styles

20

Graham, Laurel D. "Critical Biography Without Subjects and Objects: An Encounter With Dr. Lillian Moller Gilbreth." Sociological Quarterly 35, no. 4 (November 1994): 621–43. http://dx.doi.org/10.1111/j.1533-8525.1994.tb00420.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Gibson, Jane Whitney, Russell W. Clayton, Jackie W. Deem, Jacqueline Einstein, and Erin Henry. "Contributions of Lillian M. Gilbreth to Management Theory through the Context of Critical Biography." Academy of Management Proceedings 2014, no. 1 (January 2014): 11587. http://dx.doi.org/10.5465/ambpp.2014.11587abstract.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Nyland, Chris, and Mark Rix. "Mary van Kleeck, Lillian Gilbreth and the Women’s Bureau study of gendered labor law." Journal of Management History (Archive) 6, no. 7 (November 2000): 306–22. http://dx.doi.org/10.1108/13552520010359333.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Carlson Dean, Carol. "Primer of Scientific Management by Frank B. Gilbreth: A response to publication of Taylor’sPrinciplesinThe American Magazine." Journal of Management History (Archive) 3, no. 1 (March 1997): 31–41. http://dx.doi.org/10.1108/13552529710168852.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Travis, Isabelle. "Review of Caitjan Gainty’s “’Going After the High-Brows’: Frank Gilbreth and The Surgical Subject, 1912-1917″." Journal of Literature and Science 5, no. 1 (2012): 135–36. http://dx.doi.org/10.12929/jls.05.1.14.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Radygina, S. V. "MANAGEMENT FACTORS TO INCREASE LABOR EFFICIENCY IN STAFF EVALUATION AND MANAGEMENT EXPERT EVALUATIONS." Bulletin of Udmurt University. Series Economics and Law 29, no. 6 (November 25, 2019): 763–70. http://dx.doi.org/10.35634/2412-9593-2019-29-6-763-770.

Full text

Abstract:

The article addresses the issue of transforming preferences and motives for choosing a place of work under the influence of global world trends. Factors that encourage labor in modern conditions, as well as socially significant factors of managerial influence on increase of labor efficiency are identified and ranked. Leading theories of motivation are considered: the scientific school of Frank Gilbreth and Winslow Taylor; The School of Human Relations founded by Elton Mayo; Frederick Hercberg 's theory of "work enrichment." Factors on which the efficiency of management impact realization depends, as well as forms and types of management impact are given. The results of the study of the factors of labor efficiency of A.G. Zdravomyslov (1960s) and the results of the present research of the author of the article are compared. The article examines the factors that encourage a modern person to work, and defines the impact of the management style of a manager on the work efficiency of employees. The hypothesis that if other conditions of employees' work are unchanged, the change in the management style of the manager leads to significant changes in the employee 's labor efficiency has been confirmed. The results of the study conducted by the author of the article on motives to work in modern conditions, as well as the results of the survey, interviews and sociological experiment are given.

APA, Harvard, Vancouver, ISO, and other styles

26

Garrison, D. "JANE LANCASTER. Making Time: Lillian Moller Gilbreth, a Life beyond "Cheaper By The Dozen." Boston: Northeastern University Press. 2004. Pp. xii, 415. $35.00." American Historical Review 111, no. 2 (April 1, 2006): 494–95. http://dx.doi.org/10.1086/ahr.111.2.494.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Mcaleavey, Maia. "Anti-individualism in the Victorian Family Chronicle." Novel 53, no. 2 (August 1, 2020): 213–34. http://dx.doi.org/10.1215/00295132-8309569.

Full text

Abstract:

Abstract The bildungsroman privileges singularity: the unique and, often, the only child. This essay turns away from familiar literary narratives of a protagonist's personal development in order to examine the narrative possibilities of a genre that instead maintains focus on a group of siblings: the Victorian family chronicle. Family chronicles understand their large families as systems; they celebrate the replaceability of relationships rather than the irreplaceability of individuals. By insisting that a flourishing group can function in the absence of any particular person, they achieve fulfillment not in individualist plots but in group activities and brimful houses. The most influential Victorian family chronicler was Charlotte Mary Yonge. Yonge's episodic form was taken up by Anthony Trollope, Margaret Oliphant, Louisa May Alcott, and Margaret Sidney. These writers’ chronicles are non-protagonistic, nearly plotless, and potentially endless. They have been dismissed as minor works; nonetheless the anti-individualism of the large family chronicle offers an innovative approach to the nineteenth-century novel's tense negotiation between individual needs and group membership. Glimpses of chronicle narration can be seen operating within and against the competitive character systems that dominate canonical Victorian novels. A twentieth-century variant, Gilbreth and Carey's Cheaper by the Dozen, proves that the mutualistic form is also capable of hardening the boundaries around a family unit in order to compete in a capitalist marketplace. Nonetheless, the family chronicles developed by Yonge model a social economy in which both narrative and economic resources are not concentrated on a single striver but are distributed across a system.

APA, Harvard, Vancouver, ISO, and other styles

28

Lytovchenko, Iryna. "Origins and Formation of Corporate Education in the USA." Comparative Professional Pedagogy 5, no. 3 (August 1, 2015): 53–57. http://dx.doi.org/10.1515/rpp-2015-0054.

Full text

Abstract:

Abstract The article analyzes the process of formation and development of corporate education in the USA in the first half of the twentieth century. It has been determined that the main prerequisites for the development of corporate education in the USA in the first half of the twentieth century were historical, socio-economic, political factors and advances in scientific research including: the rapid growth of the US economy in the twentieth century; dissemination of scientific and technological progress and constant introduction of new technologies in the workplace; a national policy of “welfarism”; scientific works of R. Kelly “Training industrial workers” and D. Morris “Employee training: A study of education and training departments in various corporations”, which contained the first complex researches on training in industry, substantiated the necessity and prospects of this study, analyzed corporate programs of that time, the ideas on scientific management of F. Taylor, F. Gilbreth and S. Thompson, which had a major impact on all business areas. It has been found out that corporate education was the result of evolution of apprenticeship, the oldest and most traditional form of vocational training in the United States. By 1920s a new concept of modern education had been formed in the workplace which had its philosophical foundations, educational programs, technologies, system of providing services and organizational structure. In the period between the First and Second World Wars a new vision of learning at the workplace arose, new teaching methods were developed different from those used in traditional educational institutions; understanding came that the dissemination of knowledge within the whole community would contribute to building a democratic society.

APA, Harvard, Vancouver, ISO, and other styles

29

Silver, George A. "Sensational politics readings in state and local government, edited by David C. Saffell and Terry Gilbreth. Reading, MA: Addison-Wesley, 1982, 313 pp. Price: $8.95." Journal of Policy Analysis and Management 2, no. 2 (February 1, 2007): 317. http://dx.doi.org/10.1002/pam.4050020255.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Greenlees, Janet. "Jane Lancaster. Making Time: Lillian Moller Gilbreth—A Life Beyond “Cheaper by the Dozen.” Boston: Northeastern University Press, 2004. xii + 415 pp. ISBN 1-55553-612-3, $36.00 (cloth)." Enterprise & Society 6, no. 2 (June 2005): 328–30. http://dx.doi.org/10.1017/s1467222700015469.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Greenlees, J. "Jane Lancaster. Making Time: Lillian Moller Gilbreth--A Life Beyond "Cheaper by the Dozen." Boston: Northeastern University Press, 2004. xii + 415 pp. ISBN 1-55553-612-3, $36.00 (cloth)." Enterprise and Society 6, no. 2 (June 1, 2005): 328–30. http://dx.doi.org/10.1093/es/khi043.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Brass, Daniel J., Gilbreths, William R. Spriegel, and Clark E. Myers. "The Writings of the Gilbreths." Academy of Management Review 11, no. 2 (April 1986): 448. http://dx.doi.org/10.2307/258473.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Gilbreath, Norman. "Processing process: The Gilbreath conjecture." Journal of Number Theory 131, no. 12 (December 2011): 2436–41. http://dx.doi.org/10.1016/j.jnt.2011.06.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Sellmyer, Mark A., Iris K. Lee, Kyle Kuszpit, Jyoti Roy, Alex Alfaro, Virginie Ory, Lily Cheng, et al. "Abstract A37: Evaluation of eDHFR/iTag PET reporter gene immunogenicity and application in GPC3 CAR T cells." Cancer Immunology Research 10, no. 12_Supplement (December 1, 2022): A37. http://dx.doi.org/10.1158/2326-6074.tumimm22-a37.

Full text

Abstract:

Abstract Genetically engineered medicines such as chimeric antigen receptor (CAR) T cells have great potential to be the next pillar of medical therapy beyond chemo- and traditional biologic therapies. To develop genetic medicines, new methods to understand their pharmacokinetics (PK) in humans are crucial. It is not feasible to perform traditional PK analysis for “living drugs”, because the genes themselves (in the form of DNA or RNA), are not typically responsible for the therapeutic effect. Rather, the protein products of the genes or the cells harboring the engineered genes are the actuators, and thus cannot be measured using standard HPLC or ligand binding immunoassays for PK analysis. We used a positron emission tomography (PET) reporter gene or “imaging tag” based on the intracellular bacterial enzyme dihydrofolate reductase (eDHFR) that can be paired with radiolabeled versions of trimethoprim (TMP). In this work, we evaluate the potential for immunogenicity using primary human cells and assays geared to assess low affinity and rare T cell clones that may react to eDHFR. We used overlapping pools of 15-mer eDHFR peptides and found that across 9 patients, there was little reactivity compared to EBV and CMV peptide controls. Further, the relative strength of reactivity to the eDHFR peptides was less than that of the viral peptides. Next, we showed that eDHFR iTag harboring CAR T cells were functionally comparable to unlabeled CAR T cells in vitro, and demonstrated strong, selective [18F]-TMP uptake in the eDHFR-expressing CAR T cells. Finally, using a glypican 3 (GPC3) CAR T rodent model, we performed a feasibility study to non-invasively track proliferation in antigen-harboring xenograft tumors over time with ex vivo correlation to anti-CD3 immunohistochemistry. These data demonstrate the potential for non-invasive monitoring of CAR T cells using PET imaging and translational applicability of DHFR/TMP radiotracers. Citation Format: Mark A Sellmyer, Iris K Lee, Kyle Kuszpit, Jyoti Roy, Alex Alfaro, Virginie Ory, Lily Cheng, Daniel Sutton, Emily Bosco, Christine Fazenbaker, Shabazz Novarra, Ryan Gilbreth, Nick Tschernia, Deborah Berry, Xiaoru Chen, Yuling Wu, Ryan Wong. Evaluation of eDHFR/iTag PET reporter gene immunogenicity and application in GPC3 CAR T cells [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr A37.

APA, Harvard, Vancouver, ISO, and other styles

35

Mousa, Fariss‐Terry, and David J. Lemak. "The Gilbreths' quality system stands the test of time." Journal of Management History 15, no. 2 (April 10, 2009): 198–215. http://dx.doi.org/10.1108/17511340910943822.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Chu, Nina J., Michael G. Overstreet, Ryan Gilbreth, Lori Clarke, Christina Gesse, Eric Tu, Gordon Moody, and Maria Letizia Giardino Torchia. "Abstract 2837: Synthetic TGFb blockade preserves effector function and maintains stemness of GPC3 CAR-T against hepatocellular carcinoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2837. http://dx.doi.org/10.1158/1538-7445.am2022-2837.

Full text

Abstract:

Abstract Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer-related death worldwide. Immune checkpoint inhibitors have been recently approved in the first-line setting, however only 20-30% of patients respond to the therapy and disease progression is observed in most cases. This provides strong rationale to develop new approaches to treat this unmet medical need. We designed a chimeric antigen receptor (CAR) that targets the oncofetal antigen glypican-3 (GPC3) expressed in 70-90% of HCC and identified transforming growth factor β (TGFβ) as a major suppressive factor that could limit the extent of CAR-T expansion and function. TGFβ levels are increased in advanced HCC as a result of liver fibrosis and hypoxia, which creates an immunosuppressive milieu facilitating cancer progression and poor prognosis. We tested whether the anti-tumor efficacy of a GPC3 CAR-T can be restored by abrogating this suppressive cytokine through the co-expression of dominant-negative TGFβRII (TGFβRIIDN). Results: GPC3 CAR-T expressing TGFβRIIDN showed minimal SMAD2/3 phosphorylation upon exposure to recombinant TGFβ and were more resistant to TGFβ-mediated suppression of IL-2 and interferon gamma (IFNγ) production in vitro, demonstrating functional attenuation of the TGFβ signaling pathway. In a xenograft model of a human HCC cell line overexpressing TGFβ, the TGFβRIIDN armored CAR-T achieved 100% tumor regression with 10/10 complete responders (CR) while the unarmored CAR-T had 4/10 CRs. Armoring GPC3 CAR-T with TGFβRIIDN doubled disease free survival compared to unarmored CAR-T, significantly delaying tumor recurrence. In three TGFβlow patient-derived xenograft (PDX) models, mice treated with unarmored and armored CAR-T achieved >90% tumor growth inhibition (TGI) compared to mice treated with untransduced primary T cells. In three TGFβ+ PDX models, mice treated with unarmored CAR-T achieved no significant TGI whereas mice treated with armored CAR-T achieved 60-90% TGI. The armored CAR-T cells infiltrated TGFβ+ HCC tumors more abundantly than their unarmored counterparts, expressed lower levels of immune checkpoint markers PD1 and LAG3 and higher level of the stemness marker CD27. In line with these observations, we detected significantly more IFNγ at peak response and decreased alpha-fetoprotein in the serum of mice treated with armored cells compared to mice receiving unarmored CAR-T, confirming in vivo functional superiority of TGFβRIIDN armored CAR-T therapy. Conclusions: Armoring GPC3 CAR-T with TGFβRIIDN abrogates the signaling of TGFβ in vitro and enhances the anti-tumor efficacy of GPC3 CAR-T against TGFβ-expressing HCC tumors in vivo, proving TGFβRIIDN to be an effective armoring strategy against TGFβ-expressing solid malignancies such as HCC. These data support the development of an agent for clinical application. Citation Format: Nina J. Chu, Michael G. Overstreet, Ryan Gilbreth, Lori Clarke, Christina Gesse, Eric Tu, Gordon Moody, Maria Letizia Giardino Torchia. Synthetic TGFb blockade preserves effector function and maintains stemness of GPC3 CAR-T against hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2837.

APA, Harvard, Vancouver, ISO, and other styles

37

Yang, Philip Q., and Starlita Smith. "Trends in Black-White Church Integration." Ethnic Studies Review 32, no. 1 (January 1, 2009): 1–29. http://dx.doi.org/10.1525/esr.2009.32.1.1.

Full text

Abstract:

Historically, the separation of blacks and whites in churches was well known (Gilbreath 1995; Schaefer 2005). Even in 1968, about four years after the passage of the landmark Civil Rights Act of 1964, Dr. Martin Luther King, Jr. still said that “eleven o'clock on Sunday is the most segregated hour of the week” (Gilbreath 1995:1). His reference was to the entrenched practice of black and white Americans who worshiped separately in segregated congregations even though as Christians, their faith was supposed to bring them together to love each other as brothers and sisters. King's statement was not just a casual observation. One of the few places that civil rights workers failed to integrate was churches. Black ministers and their allies were at the forefront of the church integration movement, but their stiffest opposition often came from white ministers. The irony is that belonging to the same denomination could not prevent the racial separation of their congregations. In 1964, when a group of black women civil rights activists went to a white church in St. Augustine, Florida to attend a Sunday service, the women were met by a phalanx of white people with their arms linked to keep the activists out (Bryce 2004). King's classic “Letter from a Birmingham Jail” was a response to white ministers who criticized him and the civil rights movement after a major civil rights demonstration (King [2002]).

APA, Harvard, Vancouver, ISO, and other styles

38

Goad, Jill. "Haunted Property: Slavery and the Gothic by Sarah Gilbreath Ford." Eudora Welty Review 14, no. 1 (2022): 129–34. http://dx.doi.org/10.1353/ewr.2022.0012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Temple, Jessica Jane. "Tracing Southern Storytelling in Black and White by Sarah Gilbreath Ford." Eudora Welty Review 7, no. 1 (2015): 93–96. http://dx.doi.org/10.1353/ewr.2015.0004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Bulacio-Watier, Marisol. "Tracing Southern Storytelling in Black and White by Sarah Gilbreath Ford." South Central Review 33, no. 1 (2016): 86–88. http://dx.doi.org/10.1353/scr.2016.0003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Bullough, Vern L. "Merchandising the Sanitary Napkin: Lillian Gilbreth's 1927 Survey." Signs: Journal of Women in Culture and Society 10, no. 3 (April 1985): 615–27. http://dx.doi.org/10.1086/494174.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Brogdon, Lewis. "Reconciliation Blues: a Black Evangelical’s Inside View of White Christianity – By Edward Gilbreath." Religious Studies Review 33, no. 3 (July 2007): 217–18. http://dx.doi.org/10.1111/j.1748-0922.2007.00200_14.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Gainty, Caitjan. "Mr. Gilbreth's Motion Pictures — The Evolution of Medical Efficiency." New England Journal of Medicine 374, no. 2 (January 14, 2016): 109–11. http://dx.doi.org/10.1056/nejmp1514048.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Graham, Laurel D. "Lillian Gilbreth's psychologically enriched scientific management of women consumers." Journal of Historical Research in Marketing 5, no. 3 (August 2, 2013): 351–69. http://dx.doi.org/10.1108/jhrm-02-2013-0009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Sammond, Nicholas. "Picture This: Lillian Gilbreth's Industrial Cinema for the Home." Camera Obscura: Feminism, Culture, and Media Studies 21, no. 3 (2006): 103–33. http://dx.doi.org/10.1215/02705346-2006-013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Bush, Elizabeth. "Spic-and-Span!: Lillian Gilbreth’s Wonder Kitchen by Monica Kulling." Bulletin of the Center for Children's Books 68, no. 2 (2014): 113–14. http://dx.doi.org/10.1353/bcc.2014.0836.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Graham, Laurel D. "Domesticating Efficiency: Lillian Gilbreth's Scientific Management of Homemakers, 1924-1930." Signs: Journal of Women in Culture and Society 24, no. 3 (April 1999): 633–75. http://dx.doi.org/10.1086/495368.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Moore, Phoebe V. "Tracking Affective Labour for Agility in the Quantified Workplace." Body & Society 24, no. 3 (August 17, 2018): 39–67. http://dx.doi.org/10.1177/1357034x18775203.

Full text

Abstract:

Sensory and tracking technologies are being introduced into workplaces in ways Taylor and the Gilbreths could only have imagined. New work design experiments merge wellness with productivity to measure and modulate the affective and emotional labour of resilience that is necessary to survive the turbulence of the widespread incorporation of agile management systems, in which workers are expected to take symbolic direction from machines. The Quantified Workplace project was carried out by one company that fitted sensory algorithmic devices to workers’ computers and bodies, which, this article argues, identify workers’ so-called agility and reveal management practices that track affective and emotional labour, categorized in the project as stress, subjective productivity and wellbeing. Capital’s accelerated attempts to capture more areas of work and workers’ capacities facilitate the conversion of labour power into a source of value but also results in alienation and abstraction. Participants’ resistance to participation in the Quantified Workplace reveals tensions in the labour process when affect is measured in processes of corporate change.

APA, Harvard, Vancouver, ISO, and other styles

49

Lohrke, Franz T. "Motion study for the blinded: a review of the gilbreths’ work with the visually handicapped." International Journal of Public Administration 16, no. 5 (January 1993): 667–82. http://dx.doi.org/10.1080/01900699308524817.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Cox, John Lew, and Shari J. Seaton. "System integrators and implementers: The tools of choice have expanded since the Gilbreths and Taylor." Computers & Industrial Engineering 23, no. 1-4 (November 1992): 507–10. http://dx.doi.org/10.1016/0360-8352(92)90171-f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!