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1

Zhang, Wen-Song, An Pan, Liu Yang, Yuan-Yuan Cai, Bao-Lin Liu, Ping Li, Lian-Wen Qi, Jing Li, and Qun Liu. "American Ginseng and Asian Ginseng Intervention in Diet-Induced Obese Mice: Metabolomics Reveals Distinct Metabolic Profiles." American Journal of Chinese Medicine 47, no. 04 (January 2019): 787–801. http://dx.doi.org/10.1142/s0192415x19500411.

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American ginseng and Asian ginseng, which occupy prominent positions in the list of best-selling natural products in the West and East, are suitable for different indications in the traditional pharmacological uses. Currently, the effects of American ginseng and Asian ginseng in the protection against metabolic dysfunction and the differences between them are still unknown. Herein, an untargeted metabolomics based on liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was determined. The serum metabolomics and dynamic feces metabolomics revealed significant metaboli
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2

Yip, T. T., C. N. B. Lau, P. P. H. But, and Y. C. Kong. "Quantitative Analysis of Ginsenosides in Fresh Panax Ginseng." American Journal of Chinese Medicine 13, no. 01n04 (January 1985): 77–88. http://dx.doi.org/10.1142/s0192415x85000125.

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TLC, DCC and HPLC were used to study the ginsenoside composition of the main root, lateral root, rhizomem leaves and seeds of Panax ginseng cultivated in Jilin, China. Each of these methods has advantages of its own and the ensemble reveal the special features of Jilin ginseng. Total saponin content of various plant parts in Jilin ginseng showed a mid-range value as compared to those in ginsengs reported in literature. Fresh as well as sun-dried specimens from the same batch possessed a high percentage of Rg1 in the main root and this might account for the traditional preference of this plant
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3

Lin, Jia-Wei, Yih-Giun Cherng, Li-Jen Chen, Ho-Shan Niu, Chen Kuei Chang, and Chiang-Shan Niu. "Ginseng Is Useful to Enhance Cardiac Contractility in Animals." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/723084.

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Ginseng has been shown to be effective on cardiac dysfunction. Recent evidence has highlighted the mediation of peroxisome proliferator-activated receptors (PPARs) in cardiac function. Thus, we are interested to investigate the role of PPARδin ginseng-induced modification of cardiac contractility. The isolated hearts in Langendorff apparatus and hemodynamic analysis in catheterized rats were applied to measure the actions of ginsengex vivoandin vivo. In normal rats, ginseng enhanced cardiac contractility and hemodynamicdP/dtmaxsignificantly. Both actions were diminished by GSK0660 at a dose en
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4

Kandpal, Lalit Mohan, Jayoung Lee, Hyungjin Bae, Moon S. Kim, Insuck Baek, and Byoung-Kwan Cho. "Near-Infrared Transmittance Spectral Imaging for Nondestructive Measurement of Internal Disorder in Korean Ginseng." Sensors 20, no. 1 (January 3, 2020): 273. http://dx.doi.org/10.3390/s20010273.

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The grading of ginseng (Panax ginseng) including the evaluation of internal quality attributes is essential in the ginseng industry for quality control. Assessment for inner whitening, a major internal disorder, must be conducted when identifying high quality ginseng. Conventional methods for detecting inner whitening in ginseng root samples use manual inspection, which is time-consuming and inaccurate. This study develops an internal quality measurement technique using near-infrared transmittance spectral imaging to evaluate inner whitening in ginseng samples. Principle component analysis (PC
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5

Inagaki, Tetsuya, Norihisa Katayama, Rae-Kwang Cho, Xijun Chen, and Satoru Tsuchikawa. "Near infrared estimation of concentration of ginsenosides in Asian ginseng." Journal of Near Infrared Spectroscopy 27, no. 2 (December 12, 2018): 115–22. http://dx.doi.org/10.1177/0967033518814851.

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In this study, the feasibility of near infrared reflectance spectroscopy for the quality evaluation of the main bioactive compounds, ginsenosides, in Panax ginseng was examined. Second derivative NIR spectra of standard reagents of ginsenoside Rg1, Re, Rb1, Rc, Rb2 and Rd were used for analysis. Characteristic bands were observed at around 5250 cm−1 in the spectra of ginsenoside Rg1 group (including Rg1 and Re); however, this was not to be observed on the spectra of ginsenoside Rb1 group (including Rb1, Rc, Rb2 and Rd). PLS regression models were constructed of air-dry ginseng powder samples a
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6

Yoo, Hye Hyun, Takako Yokozawa, Akiko Satoh, Ki Sung Kang, and Hyun Young Kim. "Effects of Ginseng on the Proliferation of Human Lung Fibroblasts." American Journal of Chinese Medicine 34, no. 01 (January 2006): 137–46. http://dx.doi.org/10.1142/s0192415x06003709.

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In this study, we investigated the effects of methanolic extracts of white ginseng (Panax ginseng C.A. MEYER) and two kinds of heat-treated ginseng made by steaming fresh ginseng at 100°C for 3 hours (HTG-100) or 120°C for 3 hours (HTG-120) on the cell growth of human fibroblasts. All of the tested ginseng extracts stimulated cell growth, although the effect of HTG-120 was weaker than that of the other extracts. However, none of the ginseng extracts exhibited any effect on the growth of old cells with a population doubling level (PDL) of 48.7. Flow cytometric analysis showed that ginseng extra
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7

Li, Shaokun, Li Li, Yang Jiang, Jun Wu, Honghua Sun, Mingzhu Zhao, Yue Jiang, et al. "SQUAMOSA Promoter Binding Protein-Like (SPL) Gene Family: TRANSCRIPTOME-Wide Identification, Phylogenetic Relationship, Expression Patterns and Network Interaction Analysis in Panax ginseng C. A. Meyer." Plants 9, no. 3 (March 11, 2020): 354. http://dx.doi.org/10.3390/plants9030354.

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SPL (SQUAMOSA promoter binding protein-like) gene family is specific transcription factor in the plant that have an important function for plant growth and development. Although the SPL gene family has been widely studied and reported in many various plant species from gymnosperm to angiosperm, there are no systematic studies and reports about the SPL gene family in Panax ginseng C. A. Meyer. In this study, we conducted transcriptome-wide identification, evolutionary analysis, structure analysis, and expression characteristics analysis of SPL gene family in Panax ginseng by bioinformatics. We
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8

Chen, Wei, Prabhu Balan, and David G. Popovich. "Analysis of Ginsenoside Content (Panax ginseng) from Different Regions." Molecules 24, no. 19 (September 26, 2019): 3491. http://dx.doi.org/10.3390/molecules24193491.

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Recently Panax ginseng has been grown as a secondary crop under a pine tree canopy in New Zealand (NZ). The aim of the study is to compare the average content of ginsenosides from NZ-grown ginseng and its original native locations (China and Korea) grown ginseng. Ten batches of NZ-grown ginseng were extracted using 70% methanol and analyzed using LC-MS/MS. The average content of ginsenosides from China and Korea grown ginseng were obtained by collecting data from 30 and 17 publications featuring China and Korea grown ginseng, respectively. The average content of total ginsenosides in NZ-grown
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9

Kim, So-Hyun, Seok-Young Kim, and Hyung-Kyoon Choi. "Lipids in Ginseng (Panax ginseng) and Their Analysis." Natural Product Sciences 24, no. 1 (2018): 1. http://dx.doi.org/10.20307/nps.2018.24.1.1.

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10

Li, Lele, Yang Wang, Yang Xiu, and Shuying Liu. "Chemical Differentiation and Quantitative Analysis of Different Types of Panax Genus Stem-Leaf Based on a UPLC-Q-Exactive Orbitrap/MS Combined with Multivariate Statistical Analysis Approach." Journal of Analytical Methods in Chemistry 2018 (2018): 1–16. http://dx.doi.org/10.1155/2018/9598672.

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Two quantitative methods (−ESI full scan and −ESI PRM MS) were developed to analyze ginsenosides in ginseng stem-leaf by using UPLC-Q-Exactive Orbitrap/MS. By means of −ESI PRM MS method, the contents of eighteen ginsenosides in Asian ginseng stem-leaf (ASGSL) and American ginseng stem-leaf (AMGSL) were analyzed. The principal component analysis (PCA) model was built to discriminate Asian ginseng stem-leaf (ASGSL) from American ginseng stem-leaf (AMGSL) based on −ESI PRM MS data, and six ginsenosides (F11, Rf, R2, F1, Rb1, and Rb3) were obtained as the markers. To further explore the differenc
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11

Dyshlyuk, Lyubov, Anastasia Dmitrieva, Svetlana Ivanova, Yuliya Golubtsova, and Lev Ostroumov. "Panax ginseng callus, suspension, and root cultures: extraction and qualitative analysis." Foods and Raw Materials 8, no. 2 (September 30, 2020): 369–76. http://dx.doi.org/10.21603/2308-4057-2020-2-369-376.

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Introduction. In recent years, scientists have been actively searching for medicinal plants containing biologically active substances with geroprotective properties to treat diseases of old age, in particular cancer, diabetes, cardiovascular diseases, and others. Ginseng (Panax ginseng L.) is a promising source of geroprotective compounds. We aimed to select optimal parameters for extracting organic compounds from ginseng callus, suspension, and root cultures and analyze their qualitative composition.
 Study objects and methods. We studied ginseng callus, suspension, and root cultures, as
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12

Nam, Myung Hee, Seung Il Kim, Jang Ryol Liu, Deok Chun Yang, Yong Pyo Lim, Kyung-Hoon Kwon, Jong Shin Yoo, and Young Mok Park. "Proteomic analysis of Korean ginseng (Panax ginseng C.A. Meyer)." Journal of Chromatography B 815, no. 1-2 (February 5, 2005): 147–55. http://dx.doi.org/10.1016/j.jchromb.2004.10.063.

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13

Lee, Jang-Ho, Ki-Rok Kwon, and Bae-Chun Cha. "Component Analysis of Cultivated Ginseng, Red Ginseng, Cultivated Wild Ginseng, and Red Wild Ginseng Using HPLC Method." Journal of Korean Institute of Herbal Acupuncture 11, no. 2 (June 30, 2008): 87–95. http://dx.doi.org/10.3831/kpi.2008.11.2.087.

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14

Alsayari, Abdulrhman, Abdullatif Bin Muhsinah, Dalia Almaghaslah, Sivakumar Annadurai, and Shadma Wahab. "Pharmacological Efficacy of Ginseng against Respiratory Tract Infections." Molecules 26, no. 13 (July 5, 2021): 4095. http://dx.doi.org/10.3390/molecules26134095.

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Respiratory tract infections are underestimated, as they are mild and generally not incapacitating. In clinical medicine, however, these infections are considered a prevalent problem. By 2030, the third most comprehensive reason for death worldwide will be chronic obstructive pulmonary disease (COPD), according to the World Health Organization. The current arsenal of anti-inflammatory drugs shows little or no benefits against COPD. For thousands of years, herbal drugs have been used to cure numerous illnesses; they exhibit promising results and enhance physical performance. Ginseng is one such
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15

Grigoryev, Roman O., Nadezhda K, Chirikova, and Daniil N. Olennikov. "Qualitative and quantitative analysis of the content of phenolic compounds and their derivatives in the rhizome of Panax vietnamensis Ha et Grushv." Butlerov Communications 58, no. 5 (May 31, 2019): 39–43. http://dx.doi.org/10.37952/roi-jbc-01/19-58-5-39.

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Since ancient times, it is known that all types of ginseng were widely used in Eastern folk medicine as a cure for many diseases. All species of the genus Panax, including Panax vietnamensis, contain saponins, but the phenolic composition has not been studied to date. Vietnamese ginseng is characterized by a unique composition of triterpene glycosides, among which the glycosylated derivatives of the rare triterpene aglycone, okothylol, are predominant. It is the only evergreen among ginsengs. As you know, a single plant can have different types of biological activity due to the content of diff
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16

Braccia, Clarissa, Bhakti Prinsi, Mara Colzani, Alessandra A. Altomare, Luca Espen, Yoon-Mi Lee, Giancarlo Aldini, and Kyung-Jin Yeum. "Protocol Optimization of Proteomic Analysis of Korean Ginseng (Panax ginseng Meyer)." Separations 8, no. 4 (April 19, 2021): 53. http://dx.doi.org/10.3390/separations8040053.

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The benefits of ginseng have been mainly attributed to its triterpenoids, called ginsenosides. Recent genome sequencing of the Panax ginseng has paved the way for in-depth proteomic studies of this medicinal plant. The current study was conducted to deepen the proteomic information on the root proteome of Korean ginseng. Proteomic workflow was optimized by testing two different strategies, characterized by the phenol extraction procedure, the presence or the absence of SDS-PAGE fractionation step, and nano-scale liquid chromatographic tandem mass spectrometry (nLC-MS/MS) analysis. The results
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17

Artyukova, E. V., M. M. Kozyrenko, G. D. Reunova, T. I. Muzarok, and Yu N. Zhuravlev. "RAPD analysis of genome variability of planted ginseng,Panax ginseng." Molecular Biology 34, no. 2 (March 2000): 297–302. http://dx.doi.org/10.1007/bf02759655.

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18

Bai, Dapeng, J. Brandle, and R. Reeleder. "Genetic diversity in North American ginseng (Panax quinquefolius L.) grown in Ontario detected by RAPD analysis." Genome 40, no. 1 (February 1, 1997): 111–15. http://dx.doi.org/10.1139/g97-015.

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Genetic diversity within North American ginseng (Panax quinquefolius L.) grown in Ontario was investigated at the DNA level using the randomly amplified polymorphic DNA (RAPD) method via the polymerase chain reaction (PCR). A total of 420 random decamers were initially screened against DNA from four ginseng plants and 78.8% of them generated RAPD fragments. Thirty-six of the decamers that generated highly repeatable polymorphic RAPD markers were selected for further RAPD analysis of the ginseng population. With these primers, 352 discernible DNA fragments were produced from DNA of 48 ginseng p
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19

Tanaka, Ken, Masayuki Kubota, Shu Zhu, Ushio Sankawa, and Katsuko Komatsu. "Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Natural Product Communications 2, no. 6 (June 2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200602.

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Analysis of ginsenosides in five Ginseng drugs derived from Panax ginseng (white ginseng), P. quinquefolius, P. japonicus produced in Japan, P. notoginseng, and P. vietnamensis using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (LC-FTICR-MS) was performed. Ginsenosides in the drugs were identified by the molecular formula obtained from high-resolution mass data and multiple stage MS/MS analysis. Twenty-six known ginsenosides were identified as the major constituents in the extracts of the Ginseng drugs. The five Ginseng drugs showed different reconstructed
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20

Baek, Seung-Hoon, Ok-Nam Bae, and Jeong-Hill Park. "Recent Methodology in Ginseng Analysis." Journal of Ginseng Research 36, no. 2 (April 15, 2012): 119–34. http://dx.doi.org/10.5142/jgr.2012.36.2.119.

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21

Qiu, Fubin, Ying Huang, Lei Sun, Xiaoxia Zhang, Zhiheng Liu, and Wei Song. "Leifsonia ginsengi sp. nov., isolated from ginseng root." International Journal of Systematic and Evolutionary Microbiology 57, no. 2 (February 1, 2007): 405–8. http://dx.doi.org/10.1099/ijs.0.64487-0.

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A Gram-positive, rod-shaped, non-motile bacterium, designated strain wged11T, was isolated from the root of ginseng, and its taxonomic position was established using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences showed that this organism formed a robust clade with recognized species of the genus Leifsonia. Strain wged11T was characterized by a high content of ω-cyclohexylundecanoic and anteiso- and iso-branched saturated fatty acids, MK-11 as the major menaquinone and dl-2,4-diaminobutyric acid in its cell-wall peptidoglycan. The DNA G+C content of strain wged11
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Lin, Wen-Neng, Hsiu-Ying Lu, Meng-Shiou Lee, Shih-Ying Yang, Hsi-Jien Chen, Yuan-Shiun Chang, and Wen-Te Chang. "Evaluation of the Cultivation Age of Dried Ginseng Radix and Its Commercial Products by Using 1H-NMR Fingerprint Analysis." American Journal of Chinese Medicine 38, no. 01 (January 2010): 205–18. http://dx.doi.org/10.1142/s0192415x10007762.

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The perfect ginseng radix is collected when the ginseng root reaches a cultivation age of six years; this ensures the best mass quality and consistency of the plant's essential bioactive components. Since traditional means of authentication via physical appearance or smell are hardly reliable, an efficient analytical method that can determine the real cultivation age of dried ginseng radix in commercial products, especially ginseng products of various dosage forms, is urgently required. In the present study, chemical fingerprint by 1H-NMR spectroscopy was used on dried ginseng radix samples wi
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23

Wang, Nan, Kangyu Wang, Shaokun Li, Yang Jiang, Li Li, Mingzhu Zhao, Yue Jiang, et al. "Transcriptome-Wide Identification, Evolutionary Analysis, and GA Stress Response of the GRAS Gene Family in Panax ginseng C. A. Meyer." Plants 9, no. 2 (February 4, 2020): 190. http://dx.doi.org/10.3390/plants9020190.

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GRAS transcription factors are a kind of plant-specific transcription factor that have been found in a variety of plants. According to previous studies, GRAS proteins are widely involved in the physiological processes of plant signal transduction, stress, growth and development. The Jilin ginseng (Panax ginseng C.A. Meyer) is a heterogeneous tetraploid perennial herb of the Araliaceae family, ginseng genus. Important information regarding the GRAS transcription factors has not been reported in ginseng. In this study, 59 Panax ginseng GRAS (PgGRAS) genes were obtained from the Jilin ginseng tra
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24

Osathanunkul, Maslin, and Panagiotis Madesis. "Bar-HRM: a reliable and fast method for species identification of ginseng (Panax ginseng, Panax notoginseng, Talinum paniculatum and Phytolacca Americana)." PeerJ 7 (September 25, 2019): e7660. http://dx.doi.org/10.7717/peerj.7660.

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Background Korean ginseng has long been famous and is one of the most well known forms of ginseng. The root of plants in the genus Panax is commonly recognized as ginseng. Different Panax species of ginseng root have been used as treatments. Although many other herbs are called ginseng, they do not contain the active compounds of ginsenosides. In Thailand, we have Thai ginseng which is of course not one of Panax species. Thai ginseng is the root from Talinum paniculatum and, due to its morphological root similarity, it is almost impossible to differentiate between them. Also, another plant spe
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Zhu, Lianlian, Xiaoning Luan, Deqiang Dou, and Luqi Huang. "Comparative Analysis of Ginsenosides and Oligosaccharides in White Ginseng (WG), red Ginseng (RG) and Black Ginseng (BG)." Journal of Chromatographic Science 57, no. 5 (March 6, 2019): 403–10. http://dx.doi.org/10.1093/chromsci/bmz004.

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26

In, Gyo, Nam-Geun Ahn, Bong-Seok Bae, Myoung-Woo Lee, Hee-Won Park, Kyoung Hwa Jang, Byung-Goo Cho, Chang Kyun Han, Chae Kyu Park, and Yi-Seong Kwak. "In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng." Journal of Ginseng Research 41, no. 3 (July 2017): 361–69. http://dx.doi.org/10.1016/j.jgr.2016.07.004.

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27

Yoon, Dahye, Bo-Ram Choi, Seohee Ma, Jae Won Lee, Ick-Hyun Jo, Young-Seob Lee, Geum-Soog Kim, Suhkmann Kim, and Dae Young Lee. "Metabolomics for Age Discrimination of Ginseng Using a Multiplex Approach to HR-MAS NMR Spectroscopy, UPLC–QTOF/MS, and GC × GC–TOF/MS." Molecules 24, no. 13 (June 27, 2019): 2381. http://dx.doi.org/10.3390/molecules24132381.

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(1) Background: The ability to determine the age of ginseng is very important because the price of ginseng depends on the cultivation period. Since morphological observation is subjective, a new scientific and systematic method for determining the age of ginseng is required. (2) Methods: Three techniques were used for a metabolomics approach. High-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy was used to analyze powdered ginseng samples without extraction. Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF/M
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Wang, Yingfang, Mengyuan Peng, Yanlin Chen, Wenjuan Wang, Zhihua He, Zemin Yang, Zhiyun Lin, Mengjuan Gong, Yongqin Yin, and Yu Zeng. "Analysis of Panax ginseng miRNAs and Their Target Prediction Based on High-Throughput Sequencing." Planta Medica 85, no. 14/15 (August 21, 2019): 1168–76. http://dx.doi.org/10.1055/a-0989-7302.

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Abstract Panax ginseng has been widely and effectively used as medicine for thousands of years. However, only limited studies have been conducted to date on ginseng miRNAs. In the present study, we collected 3 ginseng samples from the Changbai Mountain in China. Small RNA libraries were constructed and sequenced on the Illumina HiSeq platform. Sequencing analyses identified 3798 miRNAs, including 298 known miRNAs and 3500 potentially novel miRNAs. The miR166, miR159, and miR396 families were among the most highly expressed miRNAs in all libraries. The results of miRNA expression analyses were
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Lee, Jae, Seung-Heon Ji, Bo-Ram Choi, Doo Choi, Yeong-Geun Lee, Hyoung-Geun Kim, Geum-Soog Kim, et al. "UPLC-QTOF/MS-Based Metabolomics Applied for the Quality Evaluation of Four Processed Panax ginseng Products." Molecules 23, no. 8 (August 17, 2018): 2062. http://dx.doi.org/10.3390/molecules23082062.

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In the food industry and herbal markets, it is critical to control the quality of processed Panax ginseng products. In this study, ultra-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UPLC-QTOF/MS)-based metabolomics was applied for the quality evaluation of white ginseng (WG), tae-geuk ginseng (TG), red ginseng (RG), and black ginseng (BG). Diverse metabolites including ginsenosides were profiled by UPLC-QTOF/MS, and the datasets of WG, TG, RG, and BG were then subjected to multivariate analyses. In principal component analysis (PCA), four processed
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Silva, Jeniffer, Yu-Jin Kim, Dexin Xiao, Johan Sukweenadhi, Tingting Hu, Woo-Saeng Kwon, Jianping Hu, Deok-Chun Yang, and Dabing Zhang. "Cytological analysis of ginseng carpel development." Protoplasma 254, no. 5 (February 2, 2017): 1909–22. http://dx.doi.org/10.1007/s00709-017-1081-4.

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Kajiwara, Hideyuki, and Andrew M. Hemmings. "Capillary electrophoretic analysis of ginseng polypeptide." Electrophoresis 19, no. 8-9 (June 1998): 1270–74. http://dx.doi.org/10.1002/elps.1150190808.

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32

Jeong, H. S., C. S. Lim, B. C. Cha, S. H. Choi, and K. R. Kwon. "Component analysis of cultivated ginseng, cultivated wild ginseng, and wild ginseng and the change of ginsenoside components in the process of red ginseng." Journal of Korean Pharmacopuncture Institute 13, no. 1 (March 31, 2010): 63–77. http://dx.doi.org/10.3831/kpi.2010.13.1.063.

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Kim, Yeon-Ju, Joon Young Park, Sri Renukadevi Balusamy, Yue Huo, Linh Khanh Nong, Hoa Thi Le, Deok Chun Yang, and Donghyuk Kim. "Comprehensive Genome Analysis on the Novel Species Sphingomonas panacis DCY99T Reveals Insights into Iron Tolerance of Ginseng." International Journal of Molecular Sciences 21, no. 6 (March 16, 2020): 2019. http://dx.doi.org/10.3390/ijms21062019.

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Plant growth-promoting rhizobacteria play vital roles not only in plant growth, but also in reducing biotic/abiotic stress. Sphingomonas panacis DCY99T is isolated from soil and root of Panax ginseng with rusty root disease, characterized by raised reddish-brown root and this is seriously affects ginseng cultivation. To investigate the relationship between 159 sequenced Sphingomonas strains, pan-genome analysis was carried out, which suggested genomic diversity of the Sphingomonas genus. Comparative analysis of S. panacis DCY99T with Sphingomonas sp. LK11 revealed plant growth-promoting potent
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Yu, Lide, Feiting Wei, Jian Liang, Gang Ren, Xiaofei Liu, Chong-Zhi Wang, Jinbin Yuan, et al. "Target Molecular-Based Neuroactivity Screening and Analysis of Panax ginseng by Affinity Ultrafiltration, UPLC-QTOF-MS and Molecular Docking." American Journal of Chinese Medicine 47, no. 06 (January 2019): 1345–63. http://dx.doi.org/10.1142/s0192415x19500691.

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Panax ginseng exerts good neuroprotective activity at the cell and animal level, but the specific bioactive compounds and action mechanism are needed to be investigated, verified, and confirmed. In this work, affinity ultrafiltration (AUF), UPLC-QTOF-MS, and molecular docking were integrated into one strategy to screen, identify, and evaluate the bioactive compounds in ginseng at the molecular level. Three biological macromolecules (AChE, MAO-B, and NMDA receptor) were selected as the target protein for AUF-MS screening for the first time, and 16 potential neuroactive compounds were found with
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Lee, Kyung Jun, Jung-Ro Lee, Raveendar Sebastin, Gyu-Taek Cho, and Do Yoon Hyun. "Molecular Genetic Diversity and Population Structure of Ginseng Germplasm in RDA-Genebank: Implications for Breeding and Conservation." Agronomy 10, no. 1 (January 3, 2020): 68. http://dx.doi.org/10.3390/agronomy10010068.

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Ginseng (Panax ginseng C.A. Meyer), commonly known as Korean or Asian ginseng, is a perennial herb native to Korea and China. There has been limited research effort to analyze the genetic diversity and population structure of ginseng germplasm because of its growth habits. In the present study, genetic diversity and population structure of ginseng germplasm conserved in the National Agrobiodiversity Center (NAC) of South Korea were analyzed to provide basic data for future preservation and breeding of ginseng genetic resources. Seventeen simple sequence repeat (SSR) markers were used to assess
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Nagappan, Arulkumar, Nithya Karunanithi, Sundareswaran Sentrayaperumal, Kwang-II Park, Hyeon-Soo Park, Do Hoon Lee, Sang-Rim Kang, et al. "Comparative Root Protein Profiles of Korean Ginseng (Panax ginseng) and Indian Ginseng (Withania somnifera)." American Journal of Chinese Medicine 40, no. 01 (January 2012): 203–18. http://dx.doi.org/10.1142/s0192415x12500164.

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Ginsenosides and withanolides are the secondary metabolites from Panax ginseng and Withania somnifera, respectively. These compounds have similar biological properties. Two-dimensional electrophoresis (2-DE) analysis was utilized to reveal the protein profile in the roots of both plants, with the aim of clarifying similarly- and differentially-expressed proteins. Total proteins of Korea ginseng (P. ginseng) and Indian ginseng (W. somnifera) roots were separated by 2-DE using a pH 4–7 immobilized pH gradient strip in the first dimension and 12% sodium dodecyl sulfate polyacrylamide gel electrop
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Jeong, Jae Won, Sungsoo Lim, Tae-Kyun Kim, and Seung Gyu Kim. "Consumer Preference Analysis of Korean Red Ginseng Tonic for Revitalizing Korean Ginseng Industry." Journal of Agriculture & Life Science 52, no. 6 (December 31, 2018): 155–62. http://dx.doi.org/10.14397/jals.2018.52.6.155.

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38

Park, Hae Eun, Seok-Young Lee, Sun-Hee Hyun, Da Yeon Kim, Philip J. Marriott, and Hyung-Kyoon Choi. "Gas Chromatography/Mass Spectrometry-Based Metabolic Profiling and Differentiation of Ginseng Roots According to Cultivation Age Using Variable Selection." Journal of AOAC INTERNATIONAL 96, no. 6 (November 1, 2013): 1266–72. http://dx.doi.org/10.5740/jaoacint.12-195.

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Abstract Ginseng roots are an important herbal resource worldwide, and the adulteration of ginseng with age is recognized as a serious problem. It is therefore crucial to develop objective criteria or standard protocols for differentiating ginseng root samples according to their cultivation age. The reported study used GC/MS combined with multivariate statistical analysis with variable selection to obtain metabolic profiling and an optimal partial least squares-discriminant analysis (PLS-DA) model for the differentiation of ginseng according to cultivation age. Relative levels of various metab
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Sloley, Brian Duff, Yi-Chan James Lin, Douglas Ridgway, Hugh Alexander Semple, Yun Kau Tam, Ronald Thomson Coutts, Raimar Löbenberg, and Nuzhat Tam-Zaman. "A Method for the Analysis of Ginsenosides, Malonyl Ginsenosides, and Hydrolyzed Ginsenosides Using High-Performance Liquid Chromatography with Ultraviolet and PositiveMode Electrospray IonizationMass Spectrometric Detection." Journal of AOAC INTERNATIONAL 89, no. 1 (January 1, 2006): 16–21. http://dx.doi.org/10.1093/jaoac/89.1.16.

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Abstract A high-performance liquid chromatographic separation coupled to diode array absorbance and positive mode electrospraymass spectrometric detection has been developed for the analysis of ginsenosides, malonyl ginsenosides, and hydrolyzed ginsenosides in extracts of Asian ginseng (Panax ginseng) and American ginseng (P. quinquefolius). The method is capable of separating, identifying, and quantifying the predominant ginsenosides found in heated alcoholic extracts of Asian and American ginseng roots routinely sold as nutraceuticals. It also separates and identifies the malonyl ginsenoside
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Ghorbani, Zahra, and Mojgan Mirghafourvand. "A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function." International Journal of Women's Health and Reproduction Sciences 7, no. 1 (May 7, 2018): 124–33. http://dx.doi.org/10.15296/ijwhr.2019.20.

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Objectives: An increase in life expectancy results in the aging population growth. This study was designed to evaluate the efficacy and adverse events of ginseng that could be used as a herbal medicine in women with sexual dysfunction. Materials and Methods: The authors of this study searched Cochrane Library, MEDLINE, Web of Science, Embase, Scopus, ProQuest, Google Scholar, and Persian databases without a time limitation until May 2018 and examined all the randomized clinical trials (RCTs) that compared the effect of different types of ginseng on sexual function of menopausal women as compar
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Guan, Yi Ming, Jin Chao Deng, Ying Ying Ma, Yu Li, and Ya Yu Zhang. "Seed-Associated Fungal Diversity and the Molecular Identification of Fusarium with Potential Threat to Ginseng (Panax ginseng) in China." Plant Disease 104, no. 2 (February 2020): 330–39. http://dx.doi.org/10.1094/pdis-09-19-1817-re.

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The utility of traditional methods for detecting seed-borne fungi is limited by the fact some fungi are unculturable or difficult to isolate. The seed-borne pathogens affecting Panax ginseng cultivation have not been fully characterized. Seed-borne fungi can be identified based on the high-throughput sequencing of internal transcribed spacer (ITS) amplicons. A hierarchical clustering tree diagram analysis based on operational taxonomic units revealed a relationship between the seed-borne fungi and the region from which the seeds were collected. This study analyzed the fungal diversity on 30 gi
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Kim, Ji Yoon, Hea Na Kim, Manoharan Saravanan, Seong Jin Heo, Haet Nim Jeong, Jang Eok Kim, Kwan Rae Kim, and Jang Hyun Hur. "Translocation of Tolclofos-methyl from Ginseng Cultivated Soil to Ginseng (Panax ginseng C. A. Meyer) and Residue Analysis of Various Pesticides in Ginseng and Soil." Korean Journal of Pesticide Science 18, no. 3 (September 30, 2014): 130–40. http://dx.doi.org/10.7585/kjps.2014.18.3.130.

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43

Ji, Li, Zhenjing Jie, Xin Ying, Qi Yue, Yifa Zhou, and Lin Sun. "Structural characterization of alkali-soluble polysaccharides from Panax ginseng C. A. Meyer." Royal Society Open Science 5, no. 3 (March 2018): 171644. http://dx.doi.org/10.1098/rsos.171644.

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Panax ginseng C. A. Meyer (ginseng) has been widely used as a herb and functional food in the world. Polysaccharides are the main active components of ginseng. In this paper, the polysaccharides were sequentially extracted by 50 mM Na 2 CO 3 , 1 M KOH and 4 M KOH from ginseng roots treated sequentially with hot water, α-amylase and ethylenediaminetetraacetic acid extraction. Na 2 CO 3 -soluble ginseng polysaccharide (NGP) was fractionated into one neutral and three acidic fractions by anion exchange and gel permeation chromatography. Fourier transform infrared, NMR and methylation analysis ind
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Song, Seung-Yeap, Dae-Hun Park, Seong-Wook Seo, Kyung-Mok Park, Chun-Sik Bae, Hong-Seok Son, Hyung-Gyun Kim, et al. "Effects of Harvest Time on Phytochemical Constituents and Biological Activities of Panax ginseng Berry Extracts." Molecules 24, no. 18 (September 13, 2019): 3343. http://dx.doi.org/10.3390/molecules24183343.

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Ginseng (Panax ginseng) has long been used as a traditional medicine for the prevention and treatment of various diseases. Generally, the harvest time and age of ginseng have been regarded as important factors determining the efficacy of ginseng. However, most studies have mainly focused on the root of ginseng, while studies on other parts of ginseng such as its berry have been relatively limited. Thus, the aim of this study iss to determine effects of harvest time on yields, phenolics/ginsenosides contents, and the antioxidant/anti-elastase activities of ethanol extracts of three- and four-ye
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Chen, Wei, Prabhu Balan, and David Glen Popovich. "Ginsenosides Analysis for New Zealand Wild Grown Panax Ginseng." Proceedings 8, no. 1 (March 5, 2019): 13. http://dx.doi.org/10.3390/proceedings2019008013.

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46

Hayward, Douglas G., Jon W. Wong, Kai Zhang, James Chang, Feng Shi, Kaushik Banerjee, and Paul Yang. "Multiresidue Pesticide Analysis in Ginseng and Spinach by Nontargeted and Targeted Screening Procedures." Journal of AOAC INTERNATIONAL 94, no. 6 (November 1, 2011): 1741–51. http://dx.doi.org/10.5740/jaoacint.sgehayward.

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Abstract Five different mass spectrometers interfaced to GC or LC were evaluated for their application to targeted and nontargeted screening of pesticides in two foods, spinach and ginseng. The five MS systems were capillary GC/MS/MS, GC-high resolution time-of-flight (GC/HR-TOF)-MS, TOF-MS interfaced with a comprehensive multidimensional GC (GCxGC/TOF-MS), an MS/MS ion trap hybrid mass (qTrap) system interfaced with an ultra-performance liquid chromatograph (UPLC-qTrap), and UPLC interfaced to an orbital trap high resolution mass spectrometer (UPLC/Orbitrap HR-MS). Each MS system was tested w
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Chen, Jing, Ying Yuan, Xiaoku Ran, Na Guo, and Deqiang Dou. "Metabolomics analysis based on a UPLC-Q-TOF-MS metabolomics approach to compare Lin-Xia-Shan-Shen and garden ginseng." RSC Advances 8, no. 53 (2018): 30616–23. http://dx.doi.org/10.1039/c8ra04823a.

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Panax ginseng Meyer which has been cultivated and grown naturally in mountainous forests is formally called “Lin-Xia-Shan-Shen” (LXSS), but when cultivated it is called garden ginseng (GG), according to the Chinese Pharmacopoeia (2015 edition).
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48

Li, Chang Cheng, Lai Wu Yin, Dong Chen, and Shu Jie Xu. "Lossless Compression of Weak Electrical Signal of Ginseng Molecule Based on Discrete Wavelet Transform and Siesta Program." Advanced Materials Research 986-987 (July 2014): 1950–53. http://dx.doi.org/10.4028/www.scientific.net/amr.986-987.1950.

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This paper proposed the electron density of time series by using the Siesta software to calculate the weak electrical signals of ginseng molecule, combining with the lifting scheme DWT to remove ginseng molecular spatial redundancy. For the acquisition and identification of weak electrical signals of ginseng molecule in physical environment , based on the analysis of collection and identification’s principles, the noise coefficient is removed to reconstruct the signal and retain the useful signal components through applying the multi-decomposition of DWT transform to divide weak electrical sig
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Park, Hye-Sung, Jae-Heung Cho, Koh-Woon Kim, Won-Seok Chung, and Mi-Yeon Song. "Effects of Panax ginseng on Obesity in Animal Models: A Systematic Review and Meta-Analysis." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–16. http://dx.doi.org/10.1155/2018/2719794.

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Objective. To determine the antiobesity effects of Panax ginseng in animals. Methods. We conducted a systematic search for all controlled trials (up to March 2017) that assessed the antiobesity effects of P. ginseng in animal obesity models in the PubMed, EMBASE, Cochrane library, Web of Science, and Scopus databases. The primary outcome was final body weight measured at the longest follow-up time after administration of the intervention. The secondary outcome was the lipid profile. We assessed methodological quality using the SYRCLE risk of bias tool, and RevMan 5.3 was used to perform a meta
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Kim, Mi-Ra, In-Hae Kim, and Jae-Han Shim. "The Analysis of Volatile Components of Fresh Ginseng, Red Ginseng and White Ginseng by Solvent Free Solid Injector (SFSI) Techniques." Korean Journal of Environmental Agriculture 24, no. 2 (June 30, 2005): 164–68. http://dx.doi.org/10.5338/kjea.2005.24.2.164.

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