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Relevant bibliographies by topics / GIP receptor

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Academic literature on the topic 'GIP receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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Journal articles on the topic "GIP receptor"

1

Musson, Michelle C., Lisa I. Jepeal, Patrick D. Mabray, Irina V. Zhdanova, Wellington V. Cardoso, and M. Michael Wolfe. "Expression of glucose-dependent insulinotropic polypeptide in the zebrafish." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, no. 6 (2009): R1803—R1812. http://dx.doi.org/10.1152/ajpregu.00288.2009.

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In mammals, glucose-dependent insulinotropic polypeptide (GIP) is synthesized predominately in the small intestine and functions in conjunction with insulin to promote nutrient deposition. However, little is known regarding GIP expression and function in early vertebrates like the zebrafish, a model organism representing an early stage in the evolutionary development of the compound vertebrate pancreas. Analysis of GIP and insulin ( insa) expression in zebrafish larvae by RT-PCR demonstrated that although insa was detected as early as 24 h postfertilization (hpf), GIP expression was not demons

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Mabilleau, Guillaume, Benoit Gobron, Aleksandra Mieczkowska, Rodolphe Perrot, and Daniel Chappard. "Efficacy of targeting bone-specific GIP receptor in ovariectomy-induced bone loss." Journal of Endocrinology 239, no. 2 (2018): 215–27. http://dx.doi.org/10.1530/joe-18-0214.

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Glucose-dependent insulinotropic polypeptide (GIP) has been recognized in the last decade as an important contributor of bone remodelling and is necessary for optimal bone quality. However, GIP receptors are expressed in several tissues in the body and little is known about the direct vs indirect effects of GIP on bone remodelling and quality. The aims of the present study were to validate two new GIP analogues, called [d-Ala2]-GIP-Tag and [d-Ala2]-GIP1–30, which specifically target either bone or whole-body GIP receptors, respectively; and to ascertain the beneficial effects of GIP therapy on

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Yamada, Y., and Y. Seino. "Physiology of GIP - A Lesson from GIP Receptor Knockout Mice." Hormone and Metabolic Research 36, no. 11/12 (2004): 771–74. http://dx.doi.org/10.1055/s-2004-826162.

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Lebrethon, M. C., O. Avallet, Y. Reznik, et al. "Food-Dependent Cushing’s Syndrome: Characterization and Functional Role of Gastric Inhibitory Polypeptide Receptor in the Adrenals of Three Patients1." Journal of Clinical Endocrinology & Metabolism 83, no. 12 (1998): 4514–19. http://dx.doi.org/10.1210/jcem.83.12.5336.

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In the present work, the presence of gastric inhibitory polypeptide (GIP) receptors and their functional role in the adrenal cells of three patients with food-dependent Cushing’s syndrome were studied. RT-PCR and in situ hybridization studies demonstrated the presence of GIP receptor in the adrenals of the three patients. The presence of this receptor was also demonstrated in two human fetal adrenals, but not in two normal adult human adrenals or in the adrenals of one patient with nonfood-dependent Cushing’s syndrome. Freshly isolated cells from patient adrenals responded in a dose-dependent

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Holst, Jens Juul, and Mette Marie Rosenkilde. "GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists." Journal of Clinical Endocrinology & Metabolism 105, no. 8 (2020): e2710-e2716. http://dx.doi.org/10.1210/clinem/dgaa327.

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Abstract The 2 hormones responsible for the amplification of insulin secretion after oral as opposed to intravenous nutrient administration are the gut peptides, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). However, whereas GLP-1 also inhibits appetite and food intake and improves glucose regulation in patients with type 2 diabetes (T2DM), GIP seems to be devoid of these activities, although the 2 hormones as well as their receptors are highly related. In fact, numerous studies have suggested that GIP may promote obesity. However, chimeric peptides, c

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Tseng, C. C., M. O. Boylan, L. A. Jarboe, T. B. Usdin, and M. M. Wolfe. "Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats." American Journal of Physiology-Endocrinology and Metabolism 270, no. 4 (1996): E661—E666. http://dx.doi.org/10.1152/ajpendo.1996.270.4.e661.

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Rats were rendered diabetic by streptozotocin, after which serum glucose-dependent insulinotropic polypeptide (GIP) levels, duodenal mucosal GIP content, and GIP mRNA levels were nine times, 50% and 80%, respectively, greater than in control rats. To determine whether an increase in GIP gene expression might induce chronic desensitization of its receptor, normal rats were subjected to continuous intravenous GIP infusion. Serum GIP levels increased gradually in GIP-infused rats, and by 4 h a threefold increase was detected. In response to GIP infusion, the serum insulin concentration increased

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Tura, Andrea, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, and Bo Ahrén. "Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 316, no. 1 (2019): R27—R37. http://dx.doi.org/10.1152/ajpregu.00288.2018.

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It is not known whether GIP receptor and GLP-1 receptor knockout (KO) mice have perturbations in glucagon secretion or insulin clearance, and studies on impact on fasting glycemia have previously been inconsistent in these mice. We therefore studied glucagon secretion after oral whey protein (60 mg) and intravenous arginine (6.25 mg), insulin clearance after intravenous glucose (0.35 g/kg) and fasting glucose, insulin, and glucagon levels after standardized 5-h fasting in female GIP receptor and GLP-1 receptor KO mice and their wild-type (WT) littermates. Compared with WT controls, GIP recepto

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Gallwitz, B., M. Witt, U. R. Fölsch, W. Creutzfeldt, and W. E. Schmidt. "Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7–36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells." Journal of Molecular Endocrinology 10, no. 3 (1993): 259–68. http://dx.doi.org/10.1677/jme.0.0100259.

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ABSTRACT Glucagon-like peptide-1(7–36)amide (GLP-1(7–36) amide) and gastric inhibitory polypeptide (GIP), peptides of the glucagon family, stimulate insulin secretion in vitro and in vivo. They possess high N-terminal sequence homology. Binding studies with 125I-labelled GIP and 125I-labelled GLP-1(7– 36)amide were performed in RINm5F insulinoma cells to investigate receptor specificity and to compare both receptors directly. Both binding sites were highly ligand-specific: GIP did not bind to the GLP-1(7–36)amide receptor and vice versa. Both peptides increased intracellular cyclic AMP levels;

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Greenwell, Amanda A., Jadin J. Chahade, and John R. Ussher. "Cardiovascular biology of the GIP receptor." Peptides 125 (March 2020): 170228. http://dx.doi.org/10.1016/j.peptides.2019.170228.

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Mathiesen, David S., Jonatan I. Bagger, Natasha C. Bergmann, et al. "The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion—A Review." International Journal of Molecular Sciences 20, no. 17 (2019): 4092. http://dx.doi.org/10.3390/ijms20174092.

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The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon secretion when plasma glucose concentrations are above normal fasting concentrations while GIP acts glucagonotropically at low glucose levels. A dual incretin receptor agonist designed to co-activate GLP-1 and GIP receptors was recently shown to elicit robust improvements of glycemic control (mean haemoglobin A1c reduction of 1.94%) and massiv

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Dissertations / Theses on the topic "GIP receptor"

1

Harada, Norio. "A novel gastric inhibitory polypeptide (GIP) receptor splice variant influences GIP sensitivity of pancreatic β-cells in obese mice". Kyoto University, 2008. http://hdl.handle.net/2433/135831.

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Malengo, Gabriele. "Dynamics and oligomerization of urokinase plasminogen activator receptor (uPAR): a GIP-anchored receptor studied by fluorescence micro-spectoscopy." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489898.

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This work is addressed to the search for functional links between GPI-protein monomeroligomer exchange and membrane dynamics and confinement. To this end, uPAR was chosen as a GPI-receptor involved in the regulation of cell adhesion, migration and proliferation. The work is focused on tracking the molecular dynamics and the homotypic interactions of uPAR, using fully fiinctional fluorescent protein-tagged chimeras expressed in HEK293 cells.

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Gelling, Richard Wayne. "Structure-function studies of the gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34523.pdf.

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Sankoda, Akiko. "Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice." Kyoto University, 2018. http://hdl.handle.net/2433/235060.

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Figueiredo, Cláudia Pinto. "Avaliação da expressão de receptor do peptídeo insulinotrópico dependente de glicose (GIP) em modelos experimentais de doenças neurológicas." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/92718.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2009<br>Made available in DSpace on 2012-10-24T11:31:10Z (GMT). No. of bitstreams: 1 278388.pdf: 18628569 bytes, checksum: e97674b781d8f9bf65d0e7f944c0298b (MD5)<br>Estudos prévios têm relatado um aumento na proliferação de células progenitoras neuronais, no giro denteado e no bulbo olfatório (BO) de roedores submetidos a diferentes modelos experimentais de epilepsia e doença de Parkinson. Entretanto, os fatores que controlam a proliferação e migr

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Iwasaki, Kanako. "Free Fatty Acid Receptor GPR120 is Highly Expressed in Enteroendocrine K Cells of the Upper Small Intestine and Has a Critical Role in GIP Secretion After Fat Ingestion." Kyoto University, 2016. http://hdl.handle.net/2433/215430.

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Berbel, Luciane Celeste Lazari. "Influência da variação genotípica Glu354Gln do receptor para o GIP sobre a homeostase glicêmica e a sensibilidade insulínica em indivíduos sadios." Universidade Estadual de Londrina. Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000189459.

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A possível variabilidade na resposta fisiológica hormonal após a alimentação, relacionada à elevação do GIP pós-prandial entre indivíduos, despertou o interesse para avaliar a influência do polimorfismo no gene para o receptor do polipeptídeo insulinotrópico dependente de glicose (GIPR) na homeostase glicêmica e na função da célula beta pancreática. Foram estudados 25 adultos (12 mulheres, 13 homens) com IMC<30 e sem doenças relacionadas à síndrome metabólica. Foram coletadas amostras de sangue nos tempos basal (T0) e após refeição contendo 58g de carboidratos e 28g de lipídeos a cada 30 minut

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Höfer, Martina. "Effects of a carbohydrate restricted diet on the metabolic state and progressive pancreatic beta-cell loss in transgenic mice expressing a dominant negative GIP receptor." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-67122.

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Hage, Mirella. "Mécanismes moléculaires impliqués dans la tumorigenèse et dans le comportement invasif des adénomes hypophysaires." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS352.

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Résumé : Nous avons d’abord souhaité, dans ce travail de thèse, préciser les mécanismes moléculaires conduisant à l'expression ectopique du récepteur du GIP (glucose-dependent insulinotropic polypeptide receptor, GIPR) dans des adénomes somatotropes provenant de patients présentant une acromégalie avec une réponse paradoxale (stimulation) de l’hormone de croissance au glucose par voie orale. Nous avons montré que l’expression ectopique de GIPR se produit par une activation transcriptionnelle hypomorphe du gène GIPR associée à des anomalies de méthylation dans le corps du gène. L’activation de

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Marcos, Ana Beatriz Sperb Wanderley. "Avaliação da expressão do peptídeo insulinotrópico dependente de glicose (GIP) e do seu receptor na medula espinal de animais submetidos ao modelo experimental de lesão medular traumática induzida por compressão." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/95702.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2011<br>Made available in DSpace on 2012-10-26T05:09:28Z (GMT). No. of bitstreams: 1 290474.pdf: 2552036 bytes, checksum: d3247a64708d65b8558885394fd46872 (MD5)<br>A lesão traumática da medula espinal (LTME) desencadeia uma síndrome neurológica altamente incapacitante. Uma estratégia aparentemente promissora para o tratamento da lesão medular traumática seria a intensificação dos mecanismos endógenos de neuroproteção, neuroplasticidade e re

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Books on the topic "GIP receptor"

1

Methods for the discovery and characterization of G protein-coupled receptors. Humana Press, 2011.

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Iismaa, Tiina P. G protein-coupled receptors. R.G. Landes Co., 1995.

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J, Biden Trevor, and Shine John, eds. G protein-coupled receptors. Springer-Verlag, 1995.

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Vauquelin, Georges. G protein-coupled receptors: Molecular pharmacology from academic concept to pharmaceutical research. John Wiley & Sons, 2007.

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NATO, Advanced Research Institute on Biological Signal Transduction (1990 Island of Spetsai Greece). Biological signal transduction. Springer-Verlag, 1991.

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Kendall, Harden T., and Nathanson Neil M, eds. G proteins and signal transduction: Society of General Physiologists, 43rd Annual Symposium, Marine Biological Laboratory, Woods Hole, Massachusetts, 6-9 September 1989. Rockefeller University Press, 1990.

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Society of General Physiologists. Symposium. G proteins and signal transduction: Society of General Physiologists, 43rd annual symposium : Marine Biological Laboratory, Woods hole, Massachusetts, 6-9 September 1989. Rockefeller University Press, 1990.

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Phosphoinositidase C-Linked Receptor Desenisitization. Ray Langley, 1996.

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R, George Susan, and O'Dowd Brian Francis 1950-, eds. G protein-coupled receptor-protein interactions. Wiley-Liss, 2005.

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Mason, Peggy. Receiving the Synaptic Message. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0013.

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Ionotropic and metabotropic receptors differ in their speed of action, the variety of effects produced after ligand-binding, and in the number of types present in the nervous system. The participation of two ionotropic glutamate receptors in synaptic plasticity is thought to be the cellular basis of learning. The actions of acetylcholine on nicotinic acetylcholine receptors present at the neuromuscular junction are described. The pharmacological profile of the GABAA receptor, central to most neural functions, is introduced. The properties of metabotropic receptors that are coupled to G protein

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Book chapters on the topic "GIP receptor"

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Meigs, Thomas E., Alex Lyakhovich, Hoon Shim, et al. "Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_116.

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Chandarana, Rakesh, Jacinta S. D’Souza, and Evans C. Coutinho. "Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_116.

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Buckley, N. J. "Autoradiographic Localization of Muscarinic Receptors in the Gut." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_1.

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Fox, J. E. T., E. E. Daniel, and T. J. McDonald. "Peptidergic Activation of Muscarinic M1 Inhibition in the Canine Small Intestine in Vivo." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_10.

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Stockbrügger, R. W., B. H. Jaup, W. Abrahamsson, and G. Dotevall. "Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_11.

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Giachetti, A., E. Monferini, A. Schiavone, R. Micheletti, R. Hammer, and H. Ladinsky. "Functional and Biochemical Evidence for Muscarinic Receptor Subtypes in the Gastrointestinal Tract." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_2.

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Lambrecht, G., and E. Mutschler. "Selective Inhibition of Muscarinic Receptors in Intestinal Smooth Muscle." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_3.

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North, R. A., and A. Surprenant. "Muscarinic Receptors on Neurones of the Submucous Plexus." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_4.

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Collins, S. M. "The Muscarinic Receptor Subtype on Gastric Isolated Smooth Muscle Cells." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_5.

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Kilbinger, H. "Subtypes of Muscarinic Receptors Modulating Acetylcholine Release from Myenteric Nerves." In Muscarinic Receptor Subtypes in the GI Tract. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70668-4_6.

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Conference papers on the topic "GIP receptor"

1

Vanhoutte, Paul M. "PLATELETS, ENDOTHELIUM AND VASOSPASM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643722.

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The endothelium can secrete both relaxing and contracting substances. One of the most powerful stimuli to the release of the former are thrombin and aggregating platelets. This contributes to the protective role of the endothelium against inappropriate intraluminal platelet aggregation and coagulation in blood vessels with an intact intima. Thrombin-induced, endothelium-dependent relaxations have been obtained in isolated arteries of different species, including humans. Endothelium-dependent relaxations can be evoked by autologous platelets in isolated blood vessels of the dog, pig and rat; th

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Bernard, Elise S. C., Jacky Metcalfe, Isabelle Sermadiras, et al. "GLP-1 and GIP receptors co-agonists." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.244.

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Jakobs, K. H., P. Gierschik, and R. Grandt. "THE ROLE OF GTP-BINDING PROTEINS EXHIBITING GTPase ACTIVITY IN PLATELET ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644773.

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Activation of platelets by agonists acting via cell surface-located receptors apparently involves as an early event in transmembrane signalling an interaction of the agonist-occupied receptor with a guanine nucleotide-binding regulatory protein (G-protein). The activated G-protein, then, transduces the information to the effector molecule, being responsible for the changes in intracellular second messengers. At least two changes in intracellular signal molecules are often found to be associated with platelet activation by agonists, i.e., increases in inositol trisphosphate and diacylglycerol l

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Ming-Rui, Li, Ji Xiu-Ling, Zhang Min, Chang Kwen-Jen, Liu Dong-Bo, and Wei Yun-Lin. "Establishment of a GFP Fluorescence Labeled GLP-1 Receptor Cell Line." In AASRI International Conference on Industrial Electronics and Applications (IEA 2015). Atlantis Press, 2015. http://dx.doi.org/10.2991/iea-15.2015.170.

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Chesney, C. M., and D. D. Pifer. "EFFECT OF Ca2+ and Mg2+ ON PLATELET ACTIVATING FACTOR (PAF) INDUCED AGGREGATION AND SPECIFIC BINDING TO HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642879.

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Gel filtered human platelets (GFP) collected in Tyrode's buffer containing 0.5 mM Ca+2, ImM Mg+2, and 0.35% albumin exhibit high affinity binding of 3H-PAF with a Kd of 0.109 α 0.029 nM (mean α SD; n=13) and 267 α 70 sites per platelet. When fibrinogen (1.67 mg/ml final concentration) is added to these GFP preparations biphasic aggregation is observed with PAF (4 nM). Normal aggregation is also observed with other platelet agonists including ADP, epinephrine, collagen, arachidonic acid, A23187 and thrombin. If GFP is prepared without added Ca+2 or Mg+2 in the presence of 3mM EDTA, platelets do

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Wang Jian, Craig Shankwitz, Arvind Menon, Cai Baigen, and Shangguan Wei. "Connected vehicle GID transmission and reception test with DSRC." In 2012 IEEE-APS Topical Conference on Antennas and Propagation in Wireless Communications (APWC). IEEE, 2012. http://dx.doi.org/10.1109/apwc.2012.6324968.

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Andreas, Ruf, Eberhard Morgenstern, Heinrich Patscheke, Sentot Santoso, Christian Müller-Eckhardt, and Norbert Heimburger. "THE ROLE OF THE GP IIb/IIIa COMPLEX AND vWF IN PLATELET -COLLAGEN INTERACTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643518.

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Our recent studies showed that collagen fibrils (CF) are internalized by platelets in citrated plasm. This phenomenon was not observed in EDTA-PRP. In order to investigate whether collagen internalization is mediated by a receptor we studied the effect of monoclonal antibodies against the receptor molecules GP IIb/IIIa (Gi5) and GP Ib (AN51, Da-kopatts GmbH, Hamburg). Washed human platelets from healthy donors were incubated with lOμg of Gi5 or 4μg of AN51 per ml of platelet suspension (2 × 108 platelets per ml). After 10 min. at 37° C we added AOpg collagen (Hormonchemie, München) per ml of p

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Authi, K. S., B. J. Evenden та N. Crawford. "ACTION OF GTPγS [GUANOSINE 5∲-0-(3-THIOPHOSPHATE)] ON SAPONIN-PERMEABILISED PLATELETS: INVOLVEMENT OF 'G' PROTEINS IN PLATELET ACTIVATION". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644514.

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Certain ligand-receptor interactions at cell surfaces lead to the phospholipase-C (PLC) hydrolysis of phosphatidyl inositol (4.5) bisphosphate (PIP2). The products serve as intracellular second messengers, e.g. inositol (1.4.5) trisphosphate (IP3) releases Ca2+ from intracellular stores and diacylglycerol activates protein kinase-C. From studies using GTP and analogues (e.g. GTPγS) there is evidence of a key role for a guanine nucleotide binding protein(s) as a link between receptors and PIP2 hydrolysis. We report the actions of GTPγS on washed human platelets permeabilised with saponin (12-14

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Li, Jianrong, Tianle Cheng, and Martin Y. M. Chiang. "Finite Element Modelling of Cell Adhesion Mediated by Receptor-Ligand Binding." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206297.

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The process of cell adhesion and spreading on the extracellular matrix (ECM) protein layer is mediated by the interaction of cell receptors and ECM ligands [1]. Receptors diffuse along the cell membrane surface and interact with ligands in ECM to form bonds. Cells spread and the adhesion zone grows as bond formation at the adhesion front increases to a critical level. This process involves coupling of reaction-diffusion and mechanical contact between cells and ECM. In this study, a novel numerical algorithm is developed to implement this coupling into the finite element method for modeling the

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SIMON, M. F., H. CHAP, and L. DOUSTE-BLAZY. "EFFECTS OF SIN 1 ON PLATELET ACTIVATION INDUCED BY THROMBIN IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643423.

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Abstract:

The mechanism of platelet activation is well known. The interaction of agonist such as thrombin, on specific membrane receptor induces phosphatidylinositol-specific phospholipase C activation, with a concomitant formation of two second messengers (from PIP2): inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 is able to induce a rapid discharge of Ca2+ from internal stores and Ca2+ influx through plasma membrane by unidentified Ca2+ channels linked to receptor activation. The increase of cytoplasmic free calcium concentration leads to the activation of the calcium calmodulin depe

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Reports on the topic "GIP receptor"

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Deo, Salil, David McAllister, Naveed Sattar, and Jill Pell. The time-varying cardiovascular benefits of glucagon like peptide-1 agonist (GLP-RA)therapy in patients with type 2 diabetes mellitus: A meta-analysis of multinational randomized trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.7.0097.

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Abstract:

Review question / Objective: P - patients with type 2 diabetes melllitus already receiving routine medical therapy; I - patients receiving glucagon like peptide 1 receptor agonist (GLP1 receptor agonist) therapy (semaglutide, dulaglutide, liraglutide, exenatide, lixisenatide, efpeglenatide, abiglutide); C - patients receiving standard therapy for diabetes mellitus but not receiving GLP1 agonist therapy; O - composite end point as per invididual trial, cardiovascular mortality, all-cause mortality, myocardial infarction, stoke. Condition being studied: Type 2 diabetes mellitus. Study designs to

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