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1

V.V., Ageev. "Погребения Гераев в архитектурном комплексе Мурад Рейса / The Gerays burial in the architectural complex of Murad Reis". Materialy po Arheologii i Istorii Antičnogo i Srednevekovogo Kryma (Materials in Archaeology and History of Ancient and Medieval Crimea) 6 (31 грудня 2014): 242–57. https://doi.org/10.5281/zenodo.165150.

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В настоящей работе рассматриваются захоронения Гераев на острове Родос в контексте архитектурного комплекса Мурад Рейса. В ней дается описание этого комплекса с выборочной библиографией и краткой историей изучения. В рамках публикации приводятся все выявленные на данный момент погребальные памятники Гераев в составе комплекса, показывается возможность и перспективность их дальнейшего изучения. / The paper deals with Gerays graveside on the island of Rhodes in the context of Murat Reis architectural complex. It describes the complex and provides selective bibliography and concise history of stu
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2

Deduk, Andrew V., Gennady A. Shebanin, and Alexander V. Shekov. "The Churchyard “At the Resurrection by Molodi”." Historical Geography Journal 1, no. 2 (2022): 6–17. http://dx.doi.org/10.58529/2782-6511-2022-1-2-6-17.

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When describing the Molodi battle, the main reference to where it took place is the mention of the church or the burial ground “of Resurrection by Molodi”. Traditionally, in historiography and literature on local history the place of the fight has been identified by the location of the village of Molodi situated on the right bank of the Rojayka river as a part of Zamitskaya volost of the Moscow uyezd in XVII–XVIII centuries. Although this populated center has been marked as Molodi village in the sources only starting 1646, in the earlier descriptions it is called Golovina hamlet. And the churc
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3

Liu, Yi, Xiao-Yu Song, Zhong-Yin Sun, et al. "Addition to the known diversity of Chinese freshwater planarians: integrative description of a new species of Dugesia Girard, 1850 (Platyhelminthes, Tricladida, Dugesiidae)." Zoosystematics and Evolution 98, no. (2) (2022): 233–43. https://doi.org/10.3897/zse.98.83184.

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The present paper describes a new species of freshwater flatworm of the genus Dugesia from Guizhou province, China, based on an integrative approach, combining morphological, histological and molecular information. This new species, Dugesia gemmulata Sun & Wang, sp. nov., is characterized by the ventral part of the most posterior section of the bursal canal being provided with a voluminous, ellipsoidal muscular swelling; sac- or egg-shaped seminal vesicle situated near the ventral body surface in anterior portion of the penis bulb; postero-dorsal wall of seminal vesicle communicating with
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4

Sreeparna, Banerjee, Sharma Biswas Chaiti, Pal Manoranjan, Biswas Subir, GolamHossain Md., and Bharti Premananda. "REPORTED CASES IPC CRIMES AGAINST CHILDREN IN WEST BENGAL, INDIA: A STUDY WITH RECENT DATA." International Journal of Social Sciences& Economic Environment 7, no. 1 (2022): 27–40. https://doi.org/10.53882/IJSSEE.2022.0701004.

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<strong>ABSTRACT</strong> <strong><em>Objective of the study</em></strong><em>: The present study tries to explore the variation in criminal cases of crimes against children in West Bengal vis-&agrave;-vis India during the period 2006 to 2017. </em> <strong><em>Methodology</em></strong><em>: This is mainly a descriptive study, which uses secondary information collected from the official records of the National Crime Records Bureau from 2006-2017 of India and West Bengal. The present study considers only the crimes against children that are punishable under IPC. Linear regression is carried out
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5

Letarouilly, J. G., B. Pariente, D. Staumont-Sallé, et al. "THU0393 INFLAMMATORY BOWEL DISEASES AMONG SECUKINUMAB-TREATED PATIENTS: 24 CASES FROM THE MISSIL REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 431.1–431. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2516.

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Background:An alert regarding about the tolerance of Interleukin 17 (IL-17) inhibitors has been issued from data of randomized controlled trials showing cases of de novo inflammatory bowel diseases (IBD). In a recent analysis of pooled data from 21 clinical trials, cases of IBD events (including Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBDU)) were uncommon (1). Yet, real-world data are lacking.Objectives:To describe real-world data about patients treated by IL-17 inhibitors developing new onset IBD (CD or UC).Methods:A French national registry
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6

Turgeon, D., V. Bakowsky, C. Baldwin, et al. "AB0796 CANVASC CONSENSUS RECOMMENDATIONS FOR THE USE OF AVACOPAN IN ANTINEUTROPHIL CYTOPLASM ANTIBODY-ASSOCIATED VASCULITIS: 2022 ADDENDUM." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1609.2–1610. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4793.

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BackgroundIn 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV). Since then, clinical data on the complement C5a receptor inhibitor avacopan (formerly, CCX168) has continued to expand.ObjectivesThe current addendum provides further recommendations regarding the use of avacopan in AAV based on a review of newly available evidence.MethodsAn updated systematic literature review on avacopan using Medline, Embase, and the Cochrane Library was performed for publi
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7

Gyurkocza, Boglarka, Rajneesh Nath, Stuart Seropian, et al. "Clinical Experience in the Randomized Phase 3 Sierra Trial: Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Conditioning Enables Hematopoietic Cell Transplantation with Successful Engraftment and Acceptable Safety in Patients with Active, Relapsed/Refractory AML Not Responding to Targeted Therapies." Blood 138, Supplement 1 (2021): 1791. http://dx.doi.org/10.1182/blood-2021-148497.

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Abstract Background: Several targeted therapies have been recently approved as treatment options for acute myeloid leukemia (AML), however, complete remissions (CR) in relapsed/refractory (R/R) patients remain low. Due to suboptimal responses to standard therapies, most of these patients do not receive an allogeneic hematopoietic cell transplant (HCT). In addition, AML patients ≥55 years have poor tolerance and high morbidity from a myeloablative HCT. The SIERRA trial (Study of Iomab-B in Elderly Relapsed or Refractory AML) has been investigating the use of Iomab-B, an 131I-labeled anti-CD45 m
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8

Lee, Bang-Ning, Sergio Giralt, Evan Cohen, et al. "Concordance Between the Serum Levels of Interleukin-6, Microrna-21, and the Severity of Subjective Symptoms of Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation." Blood 116, no. 21 (2010): 2953. http://dx.doi.org/10.1182/blood.v116.21.2953.2953.

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Abstract Abstract 2953 Multiple myeloma (MM) is an incurable cancer characterized by the clonal proliferation of plasma cells within the bone marrow. Current treatment for most patients with newly diagnosed MM includes induction therapy (typically dexamethasone plus thalidomide or bortezomib for patients eligible for autologous stem cell transplantation [AuSCT], melphalan and prednisone, with or without thalidomide, for those ineligible for transplantation), followed by consolidation with high-dose melphalan and AuSCT for transplant-eligible patients, and finally maintenance therapy. Intensive
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9

Noonan, Kimberly, Carol Ann Huff, Amy Sidorski, et al. "Lenalidomide Immunomodulation with an Allogeneic Myeloma GVAX in a Near Complete Remission Induces Durable Clinical Remissions." Blood 124, no. 21 (2014): 2137. http://dx.doi.org/10.1182/blood.v124.21.2137.2137.

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Abstract Background: Increasing evidence suggests that the depth of response in myeloma (MM) correlates with delayed time to progression1.We have previously shown that lenalidomide (Len) can augment vaccine efficacy to the pneumococcal conjugate vaccine (PCV), Prevnar2.We extend those observations to examine whether vaccinating patients on Len in a near complete remission (nCR) (negative M-spike, IFE positive) could further deepen the clinical response and generate measurable myeloma specific immunity in a small Phase II study. Design:Patients needed to be on a Len-containing regimen and neede
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10

Bessette, L., B. Florica, P. A. Fournier, et al. "POS0288 A CANADIAN RETROSPECTIVE CHART REVIEW EVALUATING CONCOMITANT METHOTREXATE DE-ESCALATION PATTERNS IN RA PATIENTS TREATED WITH BIOLOGIC OR TARGETED SYNTHETIC DMARDS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 388.1–389. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1286.

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BackgroundRheumatoid arthritis (RA) guidelines recommend methotrexate (MTX) as anchor therapy in combination with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). However, its tolerability is challenging with a significant proportion of patients not adhering to their prescribed MTX regimen following b/tsDMARD initiation. Rates of MTX tapering and withdrawal have been reported elsewhere but Canadian data are lacking.ObjectivesThis multi-centre, retrospective chart-based cohort study assessed the frequency of MTX withdrawal or tapering following initiation of a
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11

Puto, Marcin, Nelly G. Adel, Hani Hassoun, Sergio Giralt, and Heather Landau. "The Use of Combination PACE Regimens for Patients with Relapsed and Refractory Multiple Myeloma (MM) and Their Impact on Stem Cell Transplantation (SCT)." Blood 118, no. 21 (2011): 5127. http://dx.doi.org/10.1182/blood.v118.21.5127.5127.

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Abstract Abstract 5127 Introduction: The treatment of newly diagnosed multiple myeloma (MM) has dramatically improved with the introduction of immune modulating agents and proteasome inhibitors. However, the management of patients with relapsed or refractory disease remains challenging. For these patients, one approach is the use of the chemotherapy combination PACE (cisplatin, adriamycin, cyclophosphamide, and etoposide) in conjunction with thalidomide, lenalidomide or often bortezomib. At Memorial Sloan-Kettering Cancer Center (MSKCC), these PACE-based regimens are utilized as salvage option
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12

Pozotrigo, Melissa, Nelly G. Adel, Vincent LaRussa, et al. "Effect of Novel Agents on Stem Cell (SC) Mobilization and Engraftment In Patients with Multiple Myeloma (MM) at Memorial Sloan-Kettering Cancer Center." Blood 116, no. 21 (2010): 2262. http://dx.doi.org/10.1182/blood.v116.21.2262.2262.

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Abstract Abstract 2262 Background: In the past decade, novel agents including thalidomide, lenalidomide, and bortezomib have increasingly been incorporated in first line induction therapies in the treatment of MM with the aim of achieving the highest response rate prior to autologous stem cell transplantation (ASCT). However, reports have raised the concern that these drugs, especially lenalidomide, may impair the mobilization of sufficient stem cells for ASCT. The primary objective of this retrospective study was to determine the impact of novel agents alone and in combinations on SC mobiliza
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13

Ponce, Doris M., Craig Sauter, Marissa Lubin, et al. "A Novel Reduced Intensity Conditioning Can Induce a High Incidence of Sustained Donor Engraftment After Double Unit Cord Blood Transplantation (CBT) without Anti-Thymocyte Globulin." Blood 116, no. 21 (2010): 2351. http://dx.doi.org/10.1182/blood.v116.21.2351.2351.

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Abstract Abstract 2351 CBT can be curative for patients with high-risk hematologic malignancies. However, patients of older age, those with extensive prior therapy, or significant co-morbidities may not tolerate high-dose myeloablative conditioning. Reduced intensity (RI) or non-myeloablative (NMA) conditioning has been successfully used in CBT, especially in patients with lymphomas. However, patients with myeloid malignancies without extensive prior therapy have an increased risk of graft rejection following NMA CBT. Further, the addition of anti-thymocyte globulin (ATG) to enhance engraftmen
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14

Girard, C., S. Ackhar, S. Sassine, L. Chapuy, P. Jantchou, and C. Deslandres. "A203 EARLY PROACTIVE DRUG MONITORING STRATEGY OF INFLIXIMAB AS MONOTHERAPY FOR INFLAMMATORY BOWEL DISEASE IN PAEDIATRIC PATIENTS IS ASSOCIATED WITH GOOD SUSTAINED CLINICAL REMISSION." Journal of the Canadian Association of Gastroenterology 6, Supplement_1 (2023): 44. http://dx.doi.org/10.1093/jcag/gwac036.203.

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Abstract Background Monotherapy with Infliximab (IFX) can be as efficient as combotherapy with immunomodulators in the treatment and maintenance of remission for children with inflammatory bowel disease (IBD) if an early proactive therapeutic drug monitoring strategy is adequately performed. This strategy may allow optimization of blood levels of IFX in order to obtain a sustained clinical response. Purpose This study demonstrated that with appropriate early trough levels of IFX before dose #3 and dose #4 , monotherapy was very efficient in inducing remssion at week 52 . Method A retrospective
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15

Dacheva, R., G. Vasilev, K. Tumangelova-Yuzeir, D. Kyurkchiev, and S. Monov. "AB0654 Elevated Circulating Levels of IL-33 in Systemic Sclerosis Patients with Interstitial Lung Disease." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1454.1–1454. http://dx.doi.org/10.1136/annrheumdis-2022-eular.615.

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BackgroundSystemic sclerosis (SSc) is a chronic autoimmune disease characterized by immune dysregulation, vasculopathy and progressive skin and internal organ fibrosis. Interstitial lung disease (ILD) remains a leading cause of morbidity and mortality in SSc patients. Interleukin 33 (IL-33) is a member of the IL-1 superfamily and has been previously described as a pro-fibrotic cytokine that exerts its function by inducing Th2 cells differentiation and stimulating the expression of TGF-β. Previous reports have revealed the role of IL-33 in numerous fibrotic diseases.ObjectivesThe aim of the pre
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16

Kosuri, Satyajit, Patrick Hilden, Sean Devlin, et al. "Age-Adjusted Co-Morbidity Score - but Not Revised Disease Risk Index - Is Associated with Progression-Free Survival after Intermediate Intensity Double Unit CBT in Adults with Hematologic Malignancies." Blood 126, no. 23 (2015): 3231. http://dx.doi.org/10.1182/blood.v126.23.3231.3231.

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Abstract Introduction: CB transplantation (CBT) after intermediate intensity conditioning is a less toxic alternative to CBT after high dose myeloablation. However, determinants of progression-free survival (PFS) and the impact of the pre-transplant revised Disease Risk Index (rDRI) and age-adjusted Hematopoietic Cell Transplant Co-morbidity Index (aaHCT-CI) are not established. Methods: We evaluated 2-year PFS in double-unit CBT (dCBT) recipients with hematologic malignancies who were conditioned with a myeloablative but intermediate intensity regimen of cyclophosphamide 50 mg/kg, fludarabine
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17

Metheny, Leland, Ronald M. Sobecks, Christina Cho, et al. "Post-Transplant Inotuzumab Ozogamicin for Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (2021): 2899. http://dx.doi.org/10.1182/blood-2021-153041.

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Abstract Background: The curative potential of allogeneic transplant (alloHCT) in patients with acute lymphoblastic leukemia (ALL) is hampered by relapse; the major cause of treatment failure. Risk factors for relapse include measurable residual disease (MRD) before or after alloHCT, transplantation in second complete remission (CR) or beyond, and reduced intensity conditioning (RIC) regimens. In ALL patients, relapse rates range from 30% to 50%, with most relapses occurring within the first year after alloHCT. After relapse, options for disease control are limited, and consequently overall su
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18

Billel, Gasmi, Eric L. Smith, Ahmet Dogan, et al. "Presence of PD-1 Expressing T Cells Predicts for Inferior Overall Survival in Newly Diagnosed Multiple Myeloma." Blood 126, no. 23 (2015): 1785. http://dx.doi.org/10.1182/blood.v126.23.1785.1785.

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Abstract Background: Programmed cell death 1 (PD-1) protein downregulates T cell activation and is related to immune tolerance. PDL1 up regulation, T cell infiltration, and T cell exhaustion are features, which suggest susceptibility to PD-1 blockade antibodies. Blockade of PD-1 or its ligand PD-L1 has shown promising responses in several malignancies. Although little clinical activity has been seen in patients with relapsed multiple myeloma (MM), the role of the PD-1 pathway and T cell exhaustion in newly diagnosed MM has not been explored. Objective: To determine whether T-cell infiltrate or
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19

Tamari, Roni, Proli Anthony, Juntig Zheng, et al. "Impact of Busulphan Exposure on Transplant Outcomes for Patients with Advanced Myelodysplastic Syndromes Undergoing CD34 Selected Allogeneic Hematopoietic Cell Transplantation." Blood 126, no. 23 (2015): 1911. http://dx.doi.org/10.1182/blood.v126.23.1911.1911.

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Abstract CD34 selected stem cell transplants (SCT) have shown similar survival rates as unmodified SCT, with lower incidence of acute and chronic graft-versus-host disease (GVHD). A common conditioning regimen for patients with advanced myelodysplastic syndrome (MDS) undergoing CD34 selected SCT is a combination of busulphan, melphalan, fludarabine, and anti- thymocyte globulin (ATG). The ideal area under the curve (AUC) and overall dose intensity of busulphan is unknown in these pts. We aimed to study the relationship between busulfan AUCs and transplant outcomes in this pt population. This r
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20

Martorell Linares, Miguel. "“Procuraré morir matando o acabará mi vida”: el duelista y la muerte." Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 12 (June 28, 2023): 105–24. http://dx.doi.org/10.18239/vdh_2023.12.05.

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RESUMENEl riesgo de morir en duelo fue consustancial a la cultura del honor. Incluso en países, como Francia o España, donde la muerte en duelo no era habitual. El nexo entre honor y vida, o entre sus contrarios, deshonor y muerte, permeaba el imaginario cultural de las élites liberales. La épica de los duelos giraba en torno a la probabilidad de que un combatiente pereciera, y aun cuando la muerte no fuese el objetivo buscado en el lance, siempre pesaba la incertidumbre: la amenaza de recibir una estocada dolorosa o la eventualidad de una lesión grave. La muerte planeaba sobre los desafíos y
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21

Choquette, D., V. Chandran, M. C. Laliberté, et al. "AB0895 Residual burden and disease activity of Canadian PsA patients treated with advanced therapies: preliminary results from a multiple registry analysis (UNISON-PsA)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1575–76. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1606.

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BackgroundGiven the availability of advanced therapies in PsA with different modes of action, it is of interest to characterize their impact on overall clinical outcomes.ObjectivesTo describe residual disease activity in Canadians with PsA treated with advanced therapies.MethodsMulti-region, observational, retrospective analysis of data from Rhumadata (Quebec) and International Psoriasis and Arthritis Research Team (IPART) Canadian registries was performed. Data from each registry and region were analyzed separately using a common statistical analysis plan to generate descriptive statistics. P
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22

Finkelstein, N., R. M. Dayam, J. Law, et al. "POS1217 ANTI-TNF THERAPY FOR IMMUNE MEDIATED INFLAMMATORY DISEASES MAY BE ASSOCIATED WITH LOWER ANTIBODY LEVELS AND VIRUS NEUTRALIZATION EFFICACY FOLLOWING SARS-CoV-2 mRNA VACCINATION." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 938–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1667.

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BackgroundThe impact of immunosuppressants on COVID-19 vaccination response and durability in patients with immune-mediated inflammatory diseases (IMID) is yet to be fully characterized. Humoral response may be attenuated in these patients especially those on B cell depleting therapy and higher doses of corticosteroids, but data regarding other immunosuppressants are scarce.ObjectivesWe aimed to investigate antibody and T cell responses and durability to SARS-CoV-2 mRNA vaccines (BNT162b and/or mRNA 1273) in IMID patients on immunomodulatory maintenance therapy other than B-cell depleting ther
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23

Hummler, Madeleine. "Burial in late prehistoric France - Jean-Pierre Giraud, Fabrice Pons & Thierry Janin (ed.). Nécropoles protohistoriques de la région de Castres (Tarn): Le Causse, Gourjade, Le Martinet (Documents d’archéologie française Vol. 94). i+775 pages, 311 figures, 218 plates, 40 tables (3 volumes). 2003. Paris: Maison des sciences de l’Homme; 2-7351-0980-1 (Vol. 1 2-7351-0981-X, Vol. 2 2-7351-0982-8, Vol. 3 2-7351-0983-6; ISSN 1255-2127) paperback  75. - Luc Baray. Pratiques funéraires et sociétés de l’âge du Fer dans le Bassin parisien (fin du VIIè s. – troisième quart du IIè s. avant J.-C) (56th Gallia Suppl.). 454 pages, 61 figures, 65 tables, CD-ROM. 2003. Paris: CNRS; 2-271-05796-5 (ISSN 0072-0119) paperback  120." Antiquity 78, no. 302 (2004): 927–30. http://dx.doi.org/10.1017/s0003598x00113584.

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Dr, Jeroen Staring. "Caroline Pratt's Do-With Toys™ and Unit Blocks." International Journal of Case Studies 7, no. 9 (2018): 01–27. https://doi.org/10.5281/zenodo.3540515.

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Jeroen, Staring, Aldridge Jerry, and Bouchard Ed. "The Life and Educational Works of Mary S. Marot from 1900-1920." International Journal of Case Studies 3, no. 12 (2014): 21–31. https://doi.org/10.5281/zenodo.3523980.

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While much of what has been written about the life and works of Helen Marot involved her work as Secretary of the New York City branch of the Women&rsquo;s Trade Union League, little has been written about Mary S. Marot, Helen&rsquo;s oldest sister, founding mother of the New York City Visiting Teacher program and initiator of the School Records programs. Even less is known about the influence of Mary Marot on educational renewal and progressive education. Yet, throughout the first two decades of the 20th century, Mary Marot was involved in political, social, as well as educational endeavors.
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Hefdhallah, Al-Aizari, Achaouch Abdelaziz, Fadli Mohamed, Al-Mashreki Mohammed, and Al-Kadse Fouad. "Physico-Chemical Analysis of Selected Groundwater Samples in Dhamar basin area, Yemen." Biolife 5, no. 4 (2022): 493–504. https://doi.org/10.5281/zenodo.7392710.

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<strong>ABSTRACT</strong> In this paper, the study aims to analyze the physicochemical properties of water in the region of Dhamar (Yemen). &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have chosen five Qa&#39;s (sectors) from the Dhamar Basin (<em>Qa &#39;sherah, Qa&#39; Samah Qa &#39;Balasan, Wadi Almawaheb, and Qa&#39; Asawad</em>). The physicochemical parameters such as T<sup>o</sup>, pH, EC and TH and the major ions Na<sup>+</sup>, k<sup>+</sup> Ca<sup>2+</sup>, Mg<sup>2+</sup>, Cl<sup>-</sup>, SO<sub>4</sub><sup>2-</sup>, HCO<sub>3</sub><sup>-</sup> were evaluated in 60 wells:
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Perttula, Timothy K., and Mark Walters. "Woodland and Caddo Period Sites at Toledo Bend Reservoir, Northwest Louisiana and East Texas." Index of Texas Archaeology Open Access Grey Literature from the Lone Star State, 2015. http://dx.doi.org/10.21112/.ita.2015.1.24.

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Toledo Bend Reservoir is one of the largest artificial lakes in the United States and the largest reservoir in the South. The lake is approximately 65 miles long and contains over 1200 miles of shoreline in both Louisiana and Texas. Construction began in 1964 with completion of the power plant, with the subsequent filling of the lake in 1969. Archaeological investigations at Toledo Bend Reservoir on the Sabine River and tributaries in both Louisiana and Texas took place primarily took during the 1960s, with survey and excavations, sometimes of a very limited nature by the University of Texas (
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KRUTKYTE, GABIJA, ARNA MARIE CATHERINE GOERG, CHRISTIAN A. GROB, et al. "268-OR: Perioperative Fully Closed-Loop vs. Standard Insulin Delivery in Adults Undergoing Major Abdominal Surgery—A Two-Center Randomized Controlled Trial." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-268-or.

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Introduction: Major abdominal surgery predisposes to hyperglycemia due to metabolic stress, inflammation, perioperative nutrition support and medication. The aim of the study was to assess the efficacy of fully closed-loop (FCL) versus usual care (UC) insulin delivery for glycemic management in major abdominal surgery patients. Methods: In this randomized controlled trial (NCT05392452) we compared perioperative use of the CamAPS HX FCL system (Dexcom G6, YspoPump, SC faster insulin aspart) with UC insulin treatment from admission until hospital discharge (max 20 days) at two tertiary hospitals
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