Relevant bibliographies by topics / Glande salive

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Academic literature on the topic 'Glande salive'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

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Journal articles on the topic "Glande salive"

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Shaari, Christopher M., Bei-Lian Wu, Hugh F. Biller, Sung-Kiang Chuang, and Ira Sanders. "Botulinum Toxin Decreases Salivation from Canine Submandibular Glands." Otolaryngology–Head and Neck Surgery 118, no. 4 (April 1998): 452–57. http://dx.doi.org/10.1177/019459989811800404.

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The objective of this study was to determine whether botulinum toxin types A and D reduced the production of saliva from the submandibular glands of 18 dogs. The left sub-mandibular glands of 8 dogs were injected with increasing doses of botulinum type A toxin (range 10 to 70 units), and the left glands of 10 dogs were injected with botulinum type D toxin (50 or 100 units). The right gland of each dog was injected with equivalent volumes of saline solution to serve as control. Six days after the injection, the lingual nerve was electrically stimulated for 10 minutes (3 mAmp, 20 Hz). The resulting volume of saliva was collected and weighed. Overall, the glands injected with types A or D toxin produced significantly less saliva than comparable glands injected with saline solution. Six of 8 dogs injected with type A toxin showed a significant decrease in saliva production (range 10.1% to 19.2%, one-sided p value = 0.0375) when compared with the controls. Nine of 10 dogs injected with type D toxin demonstrated a highly significant reduction in saliva production (total average decrease = 60%, two-sided p value = 0.001) when compared with the controls. We concluded that intraglandular injections of botulinum toxin types A and D significantly reduced the production of saliva from canine submandibular glands. The potential applications of intraglandular injections of botulinum toxin are discussed.
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Winston, D. C., B. A. Schulte, J. R. Garrett, and G. B. Proctor. "Na+, K(+)-ATPase in cat salivary glands and changes induced by nerve stimulation: an immunohistochemical study." Journal of Histochemistry & Cytochemistry 38, no. 8 (August 1990): 1187–91. http://dx.doi.org/10.1177/38.8.2164061.

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The enzyme Na+, K(+)-ATPase was localized immunohistochemically in major salivary glands of the cat before and after autonomic nerve stimulation. Immunostaining was limited to basolateral plasma membranes. Cells lining striated and excretory ducts contained abundant Na+, K(+)-ATPase and showed no changes with neural stimulation. Serous-type cells in resting glands varied in reactivity, showing weak to moderate staining intensity in the parotid gland and more uniform staining of greater intensity in the sublingual gland. In contrast, demilune cells in the resting submandibular gland showed little if any staining. Mucous-type cells were negative in all glands. Parasympathetic stimulation promoted a gradual increase in immunostaining of submandibular demilune cells, which became marked with time. Sympathetic stimulation produced no detectable changes in Na+, K(+)-ATPase immunoreactivity in any site. These results support the concept that basolateral Na+, K(+)-ATPase is essential to the formation of a near-isotonic primary saliva by serous-type cells. The mechanism whereby parasympathetic stimulation evokes a marked flow of submandibular saliva remains unexplained, but has now been shown to involve a marked increase in the immunoreactivity of Na+, K(+)-ATPase at the base of the gland's demilune cells.
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Tamin, Susyana, and Duhita Yassi. "Penyakit kelenjar saliva dan peran sialoendoskopi untuk diagnostik dan terapi." Oto Rhino Laryngologica Indonesiana 41, no. 2 (December 1, 2011): 95. http://dx.doi.org/10.32637/orli.v41i2.45.

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Background: Human salivary glands could be prone to diseases. Special tools have been createdto diagnose the disease of the glands and with the advancement of technology, better instruments weredeveloped. Purpose: We present this literature review to share the knowledge of diagnostic and therapyin today’s management of salivary gland disease. Literature Review: Human salivary glands consistedof major and minor salivary glands which produce saliva. Salivary gland secretion is a process that involves cell synthesis and active transport. Salivary gland diseases are also associated with secretion process. Sialoendosopy can be use as diagnostic and therapeutics tool in salivary glands disease. As atherapeutic tool, sialoendoscopy has a role in stone fragmentation and extraction and also dilatation ofstenosis and stricture. Conclusion: Sialoendscopy has many advantages in diagnosis and treatment ofsalivary gland disease, but its employment is still limited because of the high price and required skilledand experienced operator. Key words: salivary gland, salivary gland disease, sialoendoscopy Abstrak : Latar belakang: Kelenjar saliva manusia tidak lepas dari gangguan penyakit. Beberapa alat telahditemukan untuk diagnosis penyakit ini dan dengan semakin berkembangnya teknologi, sangat diharapkanberkembang pula alat diagnosis yang lebih baik. Tujuan: dengan tulisan ini diharapkan dapat memperluaswawasan terhadap perangkat diagnostik dan terapi pada penyakit kelenjar saliva. Tinjauan Pustaka:Kelenjar saliva manusia terdiri dari kelenjar saliva mayor dan minor yang berperan untuk memroduksisaliva. Sekresi kelenjar saliva merupakan suatu proses yang melibatkan sintesis sel dan transpor aktif.Penyakit kelenjar saliva juga berhubungan dengan proses sekresi. Sialoendoskopi dapat digunakansebagai alat diagnostik maupun terapi pada penyakit kelenjar saliva. Sebagai alat terapi, sialoendoskopidapat berperan pada fragmentasi dan ekstraksi batu serta dilatasi stenosis dan striktur. Kesimpulan:Sialoendoskopi memiliki keunggulan dalam diagnosis dan terapi penyakit kelenjar saliva, namunpenggunaannya masih terbatas karena harganya yang mahal dan diperlukan operator yang trampil danberpengalaman. Kata kunci: kelenjar saliva, penyakit kelenjar saliva, sialoendoskopi
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Karagozoglu, K. Hakki, Marco Helder, Joseph Bot, Otto Kamp, Tim Forouzanfar, Henk S. Brand, Seunghee Cha, et al. "Intraoperative visualisation and treatment of salivary glands in Sjögren’s syndrome by contrast-enhanced ultrasound sialendoscopy (CEUSS): protocol for a phase I single-centre, single-arm, exploratory study." BMJ Open 10, no. 9 (September 2020): e033542. http://dx.doi.org/10.1136/bmjopen-2019-033542.

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IntroductionWe established a promising sialendoscopic treatment for in vivo enhancement of salivation in salivary glands affected by Sjögren’s syndrome (SS). In this technique, the ducts of the salivary glands are irrigated with saline and steroids. This allows for dilatation of ductal strictures and removal of debris. Unfortunately, it is not possible to assess the delivery and penetration of saline or medications in the ductal system and parenchyma. To address this problem, we will conduct contrast-enhanced ultrasound sialendoscopy (CEUSS) using sulphur hexafluoride microbubbles. To the best of our knowledge, microbubbles have never been used for the treatment of salivary glands in SS. It is, therefore, imperative to test this application for its safety and feasibility.Methods and analysisA single-arm phase I study will be performed in 10 SS patients. Under local anaesthesia, ultrasound (US) guided infusion of the parotid and submandibular glands with microbubbles will be performed. Continuous US imaging will be used to visualise the glands, including the location of strictures and occlusions. Main outcomes will be the evaluation of safety and technical feasibility of the experimental treatment. Secondary outcomes will consist of determinations of unstimulated whole mouth saliva flow, stimulated whole mouth saliva flow, stimulated parotid saliva flow, clinical oral dryness, reported pain, xerostomia, disease activity, salivary cytokine profiles and clinical SS symptoms. Finally, salivary gland topographical alterations will be evaluated by US.Ethics and disseminationEthical approval for this study was obtained from the Medical Ethics Committee of the Amsterdam University Medical Centre, Amsterdam, The Netherlands (NL68283.029.19). data will be presented at national and international conferences and published in a peer-reviewed journal. The study will be implemented and reported in line with the Standard Protocol Items: Recommendations for Interventional Trials’ statement.Trial registration numbersThe Netherlands Trial Register: NL7731, MREC Trial Register: NL68283.029.19; Pre-results.
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Hughes, Maryanne R., and Darin C. Bennett. "Effects of saline intake, sex, and season on Pekin duck osmoregulatory organ masses and comparison with wild Mallards." Canadian Journal of Zoology 82, no. 1 (January 1, 2004): 30–40. http://dx.doi.org/10.1139/z03-206.

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Osmoregulatory organ masses of freshwater Mallards (Anas platyrhynchos) do not differ between the sexes, but drinking saline induces changes that are sexually disparate in some organs. We examined relative size of organ masses of male and female Pekin ducks (that were domesticated from Mallards) and compared their responses to saline intake with those of Mallards. Organ masses of male and female Mallards do not differ in size. The liver and kidneys are heavier in female Pekin ducks and their digestive tract (except for the proventriculus and duodenum) is longer and heavier; male Pekin ducks have heavier salt glands. Mallards acclimated to saline drinking water have enlarged salt glands but not kidneys, adrenal glands, or Harderian glands, their proventriculus tends to be shorter and lighter, the jejunum longer in males, and the ileum longer and heavier in both sexes. In Pekin ducks that drink saline, the salt and Harderian glands are larger and their kidneys (but not adrenal glands) tend to be larger; the proventriculus is unaffected, but the small intestine is lighter, but not shorter, in females. Body, salt gland, Harderian gland, ventriculus, and duodenum masses vary seasonally in Pekin ducks. Discussion considers the effects of season and sex on relative organ masses and how saline-induced changes in them reflect domestication and may influence salt tolerance.
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Izutsu, K. T., M. M. Schubert, E. L. Truelove, and D. E. Johnson. "Use of Human Minor Salivary Glands in Basic and Applied Secretion Research." Journal of Dental Research 66, no. 1_suppl (February 1987): 654–59. http://dx.doi.org/10.1177/00220345870660s108.

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Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarizations are used, and control results are discussed in the context of disease-related findings. Findings are reviewed separately for electrolytes, macromolecules, and ultrastructure. In control subjects, minor gland salivary electrolyte concentrations are dependent on flow rate, and this dependence may be altered by diseases such as cystic fibrosis as-well as by inflammatory situations such as graft-versus-host disease. There is also evidence that salivary electrolyte secretion processes are not similar in labial and palatine minor glands. Studies of salivary macromolecular composition are reviewed for control subjects and for patients with graft-versus-host disease and Sjögren's syndrome. The findings indicate that the macromolecular contents of labial and palatine gland saliva are similar, but that both are significantly different from that for major gland saliva. Finally, studies attempting to measure disease-related changes in intracellular composition are reviewed. It is concluded that the minor salivary glands are important models for the study of exocrine gland physiology and pathophysiology in man.
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Izutsu, K. T., M. M. Schubert, E. L. Truelove, and D. E. Johnson. "Use of Human Minor Salivary Glands in Basic and Applied Secretion Research." Journal of Dental Research 66, no. 2_suppl (February 1987): 654–59. http://dx.doi.org/10.1177/00220345870660s208.

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Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarizations are used, and control results are discussed in the context of disease-related findings. Findings are reviewed separately for electrolytes, macromolecules, and ultrastructure. In control subjects, minor gland salivary electrolyte concentrations are dependent on flow rate, and this dependence may be altered by diseases such as cystic fibrosis as-well as by inflammatory situations such as graft-versus-host disease. There is also evidence that salivary electrolyte secretion processes are not similar in labial and palatine minor glands. Studies of salivary macromolecular composition are reviewed for control subjects and for patients with graft-versus-host disease and Sjögren's syndrome. The findings indicate that the macromolecular contents of labial and palatine gland saliva are similar, but that both are significantly different from that for major gland saliva. Finally, studies attempting to measure disease-related changes in intracellular composition are reviewed. It is concluded that the minor salivary glands are important models for the study of exocrine gland physiology and pathophysiology in man.
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Barka, T., E. W. Gresik, and H. van der Noen. "Monoclonal antibodies against rat saliva and salivary gland antigens." Journal of Histochemistry & Cytochemistry 33, no. 3 (March 1985): 209–18. http://dx.doi.org/10.1177/33.3.2579121.

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Hybridomas were produced by the fusion of NS1 myeloma cells with spleen cells of a BALB/c mouse immunized with rat submandibular saliva. Growth of hybridomas was evident in 60/96 wells, and colonies secreting antibodies against saliva components were identified in 20 wells by using a solid phase enzyme-linked immunoassay. Cloning of cells from 12 wells yielded originally 43 hybridoma cell lines secreting anti-saliva antibodies. After recloning, one hybridoma (4Cl3) was selected for further studies. The hybridoma (4Cl3) cells were grown as ascites tumors, and the antibodies were purified from the ascitic fluid by diethylaminoethyl Affi-gel Blue chromatography. The purified antibody (MA4), immunoglobulin G1, immunoprecipitated a 39K dalton protein from submandibular saliva, and also reacted with a protein of the same electrophoretic mobility on immunoblots. From extracts of submandibular gland slices, incubated with [3H]leucine, the antibody again immunoprecipitated a 39K protein, indicating that this protein is synthesized in the gland. MA4 was used for immunocytochemical stainings of submandibular glands of rats of different ages. In general, immunostaining was seen only in acinar cells. Thus, there was no staining in the glands of 1-day-old rats that lack differentiated acinar cells. In the glands of 1- to 4-week-old rats the number of immunoreactive cells and the extent of immunostaining paralleled the differentiation of the acinar cells. In the glands of adult rats a uniform staining of the secretory granules of the acinar cells was observed. The immunoreactive 39K protein seemed to be restricted to the acinar cells in the submandibular gland; there was no immunostaining in the parotid, sublingual, or lingual salivary glands, or in the pancreas, colon, and duodenum. Stimulation of saliva secretion by isoproterenol resulted in a virtual depletion of the antigen from the acinar cells. These results indicate the feasibility of producing mouse hybridomas that secrete antibodies against rat saliva components. The monoclonal antibody at hand will be useful in analyzing the differentiation of the acinar cells, and the factors that influence this differentiation process.
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Komarova, K. V., N. N. Ratkina, and V. K. Polenichkin. "The method of assessment of salivary glands secretory function." Kazan medical journal 94, no. 2 (April 15, 2013): 245–46. http://dx.doi.org/10.17816/kmj1597.

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Aim. To develop a method for the assessment of the secretory function of salivary glands. Methods. BK-300.1 («MASSA-K», Russia) weighting machine (presicion ±0,01 g), two standard cotton swabs and two absorbent dental pads «Dry Tips» («Mölnlycke Health Care», Sweden) were used for the assessment of the secretory function of salivary glands. Each absorbent pad and cotton swabs were weighted before the procedure. The examination was performed at morning hours on a fasting patient seated on a dentist’s chair without salivation stimulation. Absorbent pads were placed on the buccal mucosa with parotid orifice at the centre of the pad. Absorbent pads and cotton swabs soaked with saliva were re-weighted after 5 minutes. The examination was repeated thrice at different visits, the mean weight of saliva from major salivary glands was calculated. Salivary function of submandibular and sublingual salivary glands was also assessed. Saliva weight was assessed for each parotid gland separately. Results. The advantages of the offered method are: ease of use, opportunity to assess each parotid, submandibular and sublingual gland separately, express evaluation, good tolerance. Conclusion. The developed method allows to get the precise result and to assess the secretory function of salivary glands accurately.
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Abdollahi, Mohammad, Bagher Minaiee, and Amir A. Yaaghoubi. "Structural and functional changes by Ciprofloxacin of rat submandibular gland." Human & Experimental Toxicology 22, no. 4 (April 2003): 177–81. http://dx.doi.org/10.1191/0960327103ht350oa.

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In the present study, the effects of Ciprofloxacin (Cipro), a fluoroquinolone antibiotic, on rat submandibular gland structure and function were examined in an acute experiment. Cipro was administered intraperitoneally at various doses (20, 40 and 80 mg/kg). Pure submandibular saliva was collected intraorally by micropolyethylene tubes under anaesthesia using a dissecting microscope. After collection of saliva, submandibular glands were removed and weighed. Flow rate, amylase activity, total protein and electrolyte concentrations were measured in saliva. Concentrations of DNA and protein were measured in the gland. All doses of Cipro (20, 40, 80 mg/kg) reduced salivary flow rate. Concentrations of salivary total protein and calcium and gland DNA were reduced by all doses of Cipro. Treatment by Cipro (80 mg/kg) induced an increase in salivary sodium and potassium concentrations. Histopathological examination of glands revealed that Cipro at doses of 40 mg/kg and 80 mg/kg induces morphological changes in the glands including irregular shape of the cerous and mucous bobbles, lack of nucleus in some cells, damage of the cytoplasmic and cell walls and presence of oncocytes in secretory ducts. It is concluded that Cipro inhibits rat submandibular gland functions consistent with structural damages to the gland that might be observed as a side effect in humans. Properties of fluoroquinolones to alter intracellular cAMP and their ability to suppress DNA and protein synthesis of acinar cells might be possible reasons for observed changes.
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Dissertations / Theses on the topic "Glande salive"

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RATOMPOSON, RATOMPONIONY GARY. "Tumeurs salivaires a manifestation parapharyngee : a propos de 13 observations cliniques." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20128.

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RIAD, FOUAD. "Regulation endocrinienne de la secretion salivaire des mineraux chez les bovins." Clermont-Ferrand 2, 1986. http://www.theses.fr/1986CLF21026.

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Larsson, Olof. "Peptides as cotransmitters in salivary secretion histochemical, biochemical and functional studies of parotid and submandibular glands /." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1989. http://catalog.hathitrust.org/api/volumes/oclc/19412146.html.

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Yuk-lun, Kam. "The efficacy of a novel lubricating system in the management of radiotherapy related xerostomia." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31981835.

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Leslie, Martin David. "Salivary gland function after radiotherapy for head and neck cancer." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341706.

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Eliasson, Lars. "On minor salivary gland secretion /." Göteborg : Department of Cariology, Institute of Odontology, Sahlgrenska Academy at Göteborg University, 2006. http://hdl.handle.net/2077/712.

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Sanderson, Christopher Mark. "Transport of IgA in rat salivary glands." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/847984/.

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Transport of polymeric immunoglobulin A (plgA) in rat salivary glands has been investigated by combined morphological and biochemical techniques in vivo and in vitro. The distribution of IgA and its cellular receptor secretory component (SC) was observed by immunoperoxidase staining of cryosections from parotid and submaxillary gland, showing serous acinar cells are the site of IgA transport into saliva. Binding of horse radish peroxidase specific IgA to parotid serous acinar cells in vitro, observed by electron microscopy, shows that only the basolateral domain of acinar cells possesses exposed SC. A combination of new cell fractionation methods and standard western blotting techniques shows that SC present on basolateral plasma membrane of parotid acinar cells has a molecular weight (mwt) >100,000 and shows a high affinity for plgA in vitro. The existence of a 73,000 mwt SC occurring with plgA in cellular fractions of parotid gland suggest cleavage of SC occurs prior to secretion. The kinetics of plgA trancytosis was studied using isolated parotid acini. Bound plgA was secreted into the incubation medium as slgA, within thirty minutes of incubation at 37°C. Secretion of plgA was initially rapid but slowed over a 2hr period of incubation at 37°C. In addition to facilitating plgA transport serous acinar cells also synthesise and secrete a diverse range of other salivary proteins which are packaged into secretion granules and secreted directly through the apical plasma membrane. It is improbable that one complex secretory pathway facilitates both bulk secretion of salivary protein and transport of plgA. Therefore secreted proteins must be selectively segregated during secretion into saliva. Secretion of proteins from acinar cells in vitro shows proteins are released at two distinct rates.
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Laplume, Sylvie. "Analyse biologique de la salive et applications dans les domaines cliniques." Paris 5, 1996. http://www.theses.fr/1996PA05P075.

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Mason, Gillian Ivy. "A study of salivary glands and saliva in health and disease." Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368520.

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Much of this thesis describes the use of immunohistochemical methods on salivary glands from patients with Sjogren's syndrome (SS) to quantify the position, nature and proliferative activity of the inflammatory cell infiltrate, deposition of cell matrix proteins and glandular expression of TGFp. Studies are also undertaken on glands from an experimental animal model and from patients with two associated conditions, benign lymphoepithelial lesion (BLEL) and systemic sclerosis (SSc). Initially a rat model of SS was examined and changes in salivary glands quantified at different stages after autoimmunisation. Immunohistochemically there were similarities to SS, in that class II antigen was expressed by glandular epithelium and the early lesions contained T lymphocytes. However, B lymphocytes were rare, the cell infiltrate contained large populations of macrophages and neutrophils, and there was evidence of increased elaboration of fibrous connective tissue. These results indicate that this animal model is of doubtful use for the study of Sjogren's syndrome. Studies on human tissue showed that the lymphocyte infiltrate in BLEL patients was more extensive than SS and that T cells predominated in small foci, whereas B cells were the dominant lymphocyte type in larger foci. In areas of extensive lymphocyte infiltration, B cells were closely associated with ducts or present in germinal centre-like structures with T cells being found elsewhere. A previously unreported feature of BLEL was the presence of intra-epithelial (and intra-lumenal) B cells, many of which were proliferating. The remaining duct walls in BLEL appeared to be under pressure due to this population of B lymphocytes and "holes" were observed both in the basement membrane and at the lumenal surface that may facilitate migration of lymphocytes from glandular stroma into duct lumens. There was significantly more tenascin and fibronectin in BLEL glands (p<0.01) compared to normal parotid controls which contained minimal amounts of these proteins. By contrast, both proteins were expressed in normal labial glands with no significant increase in glands from SS and SSc patients. As both tenascin and fibronectin are important in cell migration, increased levels may be a factor facilitating lymphoid infiltration in BLEL. Absorbance measurements demonstrated that ductal expression of TGFI differed between control, SS and BLEL salivary glands. SS glands showed an increase in expression of all isoforms of TGFß with the increase for TGFP2 and TGFP3 being significant (p=0.02 & p<0.002). By contrast, ductal expression of all isoforms of TGFI in BLEL was reduced in both confluent (p<0.0001) and minimally infiltrated (p<0.005) areas of gland. Thus reduced glandular expression of TGFJ may be important in allowing the high levels of lymphocyte and epithelial cell proliferation detected in BLEL which are rarely seen in SS. Salivary glands from SSc and Raynaud's phenomenon (RP) patients contained small, predominately T cell foci with few proliferating B cells and a significantly increased mast cell population (p<0.005). Fibrosis within the glands was variable and not associated with increased deposition of fibronectin or tenascin. Subjectively, the most obvious difference in TGFI expression in SSc compared to controls was exhibited by fibroblasts. Cell counts revealed no differences in fibroblast expression of TGFßI or TGFß receptors. However, the percentage of TGFß2-positive fibroblasts was significantly higher in SSc glands compared to controls (p<0.004). RP glands showed an intermediate level of expression. By contrast, a lower percentage of RP fibroblasts expressed TGF(33 compared to controls, with SSc glands showing an intermediate level of expression. The results indicate that both SSc and RP are associated with an increased salivary gland mast cell population and changes in expression of TGFß2 and ß3 isoforms by glandular fibroblasts. The final section of this thesis describes an investigation of antioxidant levels in saliva from healthy individuals and patients with SS or periodontal disease. The results demonstrated that in SS there was an increase in the concentration of antioxidants in unstimulated saliva but a reduced rate of production. This diminished output of salivary gland antioxidants may be of significance to the oral health of these patients. In periodontal disease there was a reduction in antioxidant levels in stimulated saliva that may have been the result of local depletion by reactive oxygen species, produced by chronic inflammation within the gingival tissues. Alternatively, these patients may have intrinsically reduced levels of antioxidants and therefore be more susceptible to periodontal disease.
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Dantas, Aline Maia. "Estudo da relação entre glândulas salivares e doença periodontal em ratos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022012-142657/.

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A gengivite e a periodontite constituem doenças periodontais infecciosas comuns do homem, nas quais as bactérias periodontais e seus produtos participam ativamente para indução da inflamação local e efeitos sistêmicos (ex.: coração). Sabendo que a saliva representa a primeira e grande barreira às infecções orais, este trabalho se propôs a: i) avaliar a perda óssea induzida pela doença periodontal em ratos submetidos à indução de doença, via implante de ligadura, após os intervalos de 3, 7 e 14 dias; ii) Investigar possíveis alterações de fluxo (estimulado ou não com pilocarpina) e composição salivar nesses animais; iii) avaliar a concentração / expressão de marcadores de estresse oxidativo e inflamatórios em glândulas salivares e em amostras de saliva; iv) avaliar o papel funcional da função das glândulas salivares ex-vivo na produção da amilase. Para isto, ratos Wistar machos (180 -200g) foram submetidos à indução da periodontite através do implante da ligadura, e os parâmetros inflamatórios e bioquímicos foram avaliados nesses animais. Ratos com periodontite no dia 3, quando comparado ao grupo sham, exibiram aumento significativo do fluxo salivar (estimulada com pilocarpina), produção de Ca2+, secreção de proteínas e produção de amilase na saliva, bem como aumento do conteúdo de TBARs em glândulas parótida e da amilase liberada das glândulas submandibulares (GSM). Observou-se, ainda, aumento da expressão de mRNA para iNOS e nNOS em GSM. Em contrapartida, ratos com periodontite após 7 dias exibiram redução da taxa de salivação estimulada (e não estimulada), da produção de proteínas totais e da concentração e secreção de amilase na saliva, muito embora o conteúdo sérico e salivar de TBARs e da atividade de MPO na saliva desses animais mostrou-se elevado em relação ao grupo sham. Não foram observadas diferenças significativas quanto ao conteúdo de TBARs em glândulas salivares, secreção e concentração de Ca2+ na saliva e tampouco sobre o conteúdo de proteínas nitradas em amostras de GSM desses animais. Já no 14° dia visualizou-se um aumento da atividade de NOS Ca2+ dependente e da expressão mRNA das iNOS e nNOS em GSM. Ratos com periodontite, após 14 dias de indução, não exibiram aumento significativo na taxa de salivação, concentração e secreção de Ca2+ salivar, produção e concentração de proteínas totais, amilase na saliva e conteúdo de TBARs em amostras de saliva e glândulas salivares. Ainda, observou-se aumento das atividades da peroxidase/MPO, concentração de nitrato em saliva e proteínas nitradas em GSM e maior concentração de citocinas Th1 / Th2 (IL-4, IL-13 e IL-10) em amostras de GSM. Conclui-se que a indução experimental da doença periodontal em ratos , influencia o funcionamento de glândulas salivares de acordo com os dias de indução, inicialmente estimulando, em um segundo momento inibindo e posteriormente retornando aos níveis basais. Após 7 dias, caracteriza-se como o tempo ideal para a manifestação dos efeitos inibitórios na glândula.
Gingivitis and periodontitis are common infectious periodontal diseases in man, in which periodontal bacteria and their products participate actively to induce local inflammation and systemic effects (eg heart). Knowing that saliva represents the first major barrier to oral infections, this study aimed to: i) to assess bone loss due to induced periodontitis in rats, after intervals of 3, 7 and 14 days, ii) to investigate possible changes in flow (or not stimulated with pilocarpine) and salivary composition in these animals, and iii) evaluate the concentration and expression of markers of oxidative stress and inflammation in the salivary glands and saliva samples, and iv) assess the functional role of salivary gland function in ex vivo production of amylase. For this purpose, male Wistar rats (180-200g) underwent induction of periodontitis by implanting the ligature, and biochemical and inflammatory parameters were assessed. Rats with periodontitis on day 3 when compared to sham group, exhibited a significant increase in salivary flow (stimulated with pilocarpine), production of Ca2+, protein secretion and production of amylase in saliva, as well as increased contents of TBARS in the parotid and amylase released from submandibular glands (GSM). There was also increased expression of mRNA for iNOS and nNOS in GSM. In contrast, rats with periodontitis after 7 days exhibited a reduction in stimulated saliva (not stimulated), production and total protein concentration and secretion of salivary amylase, although the content of serum and salivary TBARS and the activity of MPO in saliva of these animals was high compared to the sham group. There were no significant differences in TBARS content in salivary gland secretion and Ca2+ concentration in saliva, nor on the content of nitrated proteins in samples from these animals GSM. By the 14th day envisioned an increase of NOS activity and Ca2+ dependent mRNA expression of iNOS and nNOS in GSM. Rats with periodontitis, 14 days after induction, exhibited a significant increase in the rate of salivation, concentration and salivary secretion of Ca2+, production and concentration of total protein, salivary amylase and content of TBARS in samples of saliva and salivary glands. Still, there was increased activity of peroxidase / MPO, nitrate concentration in saliva and proteins nitrated in GSM and higher concentration of Th1 / Th2 (IL-4, IL-13 and IL-10) in samples of GSM. We conclude that the experimental induction of periodontal disease in rats, influence the functioning of the salivary glands according to the days of induction, initially stimulating, in a second time and subsequently inhibiting return to baseline levels. After 7 days, is characterized as the ideal time for the expression of an inhibitory effect on the gland function.
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Books on the topic "Glande salive"

1

Beers, W. George. Observations in the mouth during pregnancy and the catamenia. [S.l: s.n., 1985.

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Ligtenberg, Antoon J. M., and Enno C. I. Veerman. Saliva: Secretion and functions. Basel: Karger, 2014.

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The slimy book of spit. Mankato, Minn: Capstone Press, 2010.

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Mason, Gillian Ivy. A study of salivary glands and saliva in health and disease. Birmingham: University of Birmingham, 2001.

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Garrett, J. R., Jörgen Ekström, and L. C. Anderson. Neural mechanisms of salivary gland secretion. Basel: Karger, 1999.

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1943-, Trudel Pierre, ed. Dernière minute de jeu: Les millions du hockey. Montréal: Hurtubise HMH, 2004.

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Avantage numérique: L'argent et la Ligue nationale de hockey. Hull, Québec: Vents d'Ouest, 1997.

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Scully, Crispian, Jacobo Limeres, and Pedro Diz Dios. Saliva Protection and Transmissible Diseases. Elsevier Science & Technology Books, 2017.

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1949-, Tenovuo Jorma O., ed. Human saliva: Clinical chemistry and microbiology. Boca Raton, Fla: CRC Press, 1989.

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Saliva as a diagnostic fluid. New York, N.Y: New York Academy of Sciences, 1993.

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Book chapters on the topic "Glande salive"

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Bachalli, Prithvi S., and Aditya Moorthy. "Obstructive Salivary Gland Disease and Sialendoscopy." In Oral and Maxillofacial Surgery for the Clinician, 975–80. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_47.

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AbstractObstructive salivary pathologies most commonly manifest as salivary stones (sialoliths), mucous plugs and sometimes due to narrowing of the duct (stricture/stenosis). Saliva produced by salivary glands flows into oral cavity by means of ducts. Blockage of these ducts due to the reasons mentioned above leads to sialadenitis (inflammation).Sialendoscopy is a minimally invasive technique to manage salivary duct pathologies, including sialolithiasis, sialadenitis & strictures. It is fast becoming the investigating procedure of choice for such conditions.In the last 25 years, Sialoendoscopy has gradually seen a rise in popularity for diagnostic and therapeutic means of dealing with obstructive salivary gland pathologies.
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Agni, Nisheet Anant. "Salivary Gland Pathologies." In Oral and Maxillofacial Surgery for the Clinician, 939–73. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_46.

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AbstractSaliva is responsible for various functions from lubrication to digestion. The saliva is secreted by numerous minor and major salivary glands. These salivary glands are sometimes affected by various local and systemic inflammatory conditions, obstructive pathologies with benign and malignant tumors. This chapter deals with various pathologies of salivary glands and their management.
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Contreras-Aguilar, María D., and Francisco Gómez-García. "Salivary Glands’ Anatomy and Physiology." In Saliva in Health and Disease, 3–21. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-37681-9_1.

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Matsuo, R. "Interrelation of Taste and Saliva." In Neural Mechanisms of Salivary Gland Secretion, 185–95. Basel: KARGER, 1999. http://dx.doi.org/10.1159/000061118.

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Garrett, J. R. "Movements of Organic Molecules from Blood to Saliva and from Glands to Blood." In Frontiers of Oral Biology (Vol. 10 + 11), 153–66. Basel: KARGER, 1998. http://dx.doi.org/10.1159/000061094.

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Fox, Philip C., Margaret M. Grisius, Debra K. Bermudez, and Di Sun. "Cytokine mRNA Expression in Labial Salivary Glands and Cytokine Secretion in Parotid Saliva in Sjögren’s Syndrome." In Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2, 909–15. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5359-5_129.

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Sylla, Patricia. "The salivary glands." In Head, Neck and Dental Emergencies, 405–11. Oxford University Press, 2005. http://dx.doi.org/10.1093/med/9780198529101.003.0012.

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Salivary gland diseases—general considerations 406 Tumours 406 Calculi (stones) and strictures 407 Infections 408 Salivary gland diseases—miscellaneous considerations 410 Saliva is produced by: • major salivary glands—parotid, submandibular, and sublingual; • minor salivary glands—these line the mouth, palate, and lips, and they can occasionally be found in the nose....
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Corbridge, Rogan, and Nicholas Steventon. "The salivary glands." In Oxford Handbook of ENT and Head and Neck Surgery, 201–12. Oxford University Press, 2009. http://dx.doi.org/10.1093/med/9780199550791.003.11.

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Structure and function of the salivary glands 202 Salivary gland tumours 204 Sialadenitis 206 Sialolithiasis 207 Other inflammatory conditions 208 Pseudosalivary swellings 209 Salivary gland surgery 210 There are three main pairs of salivary glands, the: • parotid • submandibular • sublingual In addition, a number of other tiny minor salivary glands are scattered throughout the mucosa of the mouth and throat. They produce the saliva needed for digestion and lubricating the food bolus....
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"Applied Physiology of the Parotid Gland." In Diagnostic Techniques and Therapeutic Strategies for Parotid Gland Disorders, 24–33. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5603-0.ch004.

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The major function of salivary glands is the production of saliva, which performs many functions including lubrication of the food bolus, maintaining the oral cavity pH within 6 to 7, maintaining teeth integrity, fighting bacteria, aiding taste and digestion, and providing a continuous lavaging biofilm for the oral cavity. Saliva is actively produced in high volumes relative to the mass of the salivary glands and is almost completely controlled extrinsically by both parasympathetic and sympathetic divisions of the autonomic nervous system. Some researchers used bilateral tympanic neurectomy for patients with ptyalism (drooling) with good initial results. Others advocated bilateral parotid duct rerouting ± bilateral submandibular gland excision for long-term treatment of drooling. Intra-glandular Botulinum toxin may also have good results for patients with hyper-sialorrhea. Most resting salivary gland flow arises from the submandibular glands and surgery should focus on this gland to control uncontrolled sialorrhea.
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Robinson, Max, Keith Hunter, Michael Pemberton, and Philip Sloan. "Salivary gland diseases." In Soames' & Southam's Oral Pathology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199697786.003.0009.

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The salivary glands consist of three paired major glands—parotid, sub­mandibular, and sublingual—and the countless minor salivary glands found in almost every part of the oral cavity, except the gingiva and anterior regions of the hard palate. The secretion of saliva is essential for the normal function and health of the mouth, and disorders of salivary gland function predispose to oral disease. Functional disorders in salivary secretion may be associated with primary salivary gland disease but in other cases are a consequence of systemic factors, such as medi­cations, endocrine disturbances, and neurological disease, which are discussed in Chapter 10. Developmental anomalies of the salivary glands are rare. Aplasia of one or more major glands and atresia of one or more major salivary gland ducts have been reported. Congenital aplasia of the parotid gland may be associated with other facial abnormalities, e.g. ectodermal dysplasia, mandibulofacial dysostosis, and hemifacial microsomia. Heterotopic salivary tissue has been reported from a variety of sites in the head and neck region, the most frequent being its inclusion at the angle, or within the body, of the mandible, called a Stafne bone cavity. It is usually an incidental radiological finding and appears as a round or oval, well-demarcated radiolucency between the premolar region and angle of the jaw, and is typically located beneath the inferior dental canal. The radiographic appearances are due to a saucer-shaped depression or concavity of varying depth on the lingual aspect of the mandible, which contains salivary tissue in continuity with the submandibular gland. Accessory parotid tissue within the cheek or masseter muscle is rela­tively common and is subject to the same diseases that may affect the main gland. Age changes can be detected in both major and minor salivary glands. Reduction in the weights of submandibular and parotid glands has been reported with increasing age, associated in the submandibular gland with an age-dependent reduction in flow rates. By contrast, sev­eral studies have demonstrated that there is no significant reduction in parotid flow rates in the elderly.
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Conference papers on the topic "Glande salive"

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Nikonov, G., and I. Baskova. "PROTECTIVE ANTITHROMBOTIC ACTION OF THE PREPARATIONS FROM THE LEECHES HIRUDO MED ICINAL IS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643079.

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Blood letting effect of the medicinal leeches is provided by antihaemostatic properties of the salivary gland secretion. We have demonstrated that the natural salivary gland secretion inhibits the vascular-platelets haemostasis and the contact stage of the intrinsic mechnism of blood coagulation but has no effect on the activation of extrinsic mechanism (Bui 1.Exp.Biol.Med.USSR 97, 6, 696; 8, 142, 1984). Leech prostaglandins (Dokl.Acad.Nauk USSR, 1987) and inhibitors of plasma kallikrein and Factor XI la are the main anti haemostatic agents of the leech saliva.The leech saliva does not change the main parameters of blood coagulation of the healthy animals, such as recalcification time, cephalin time, thrombin and prothrombin time 5, 15 and 25 min after intravenous injection. But the platelets aggregation stimulated by thrombin is diminished by 20% (n=30;p 0,02) Recalcification time, cephalin time and platelets aggregation reduced by intravenous injection of human serum is corrected by leech saliva.As the trigger mechanisms of haemostasis are very much alike the trigger mechanisms of thrombogenes?s, we investigated antithrombotic ability of the leech saliva, extracts of dried leeches and blood of intestinal gut. We used Wessler procedure of throm-bous formation in rats.The thrombous formation was diminished by 90% compared to control when 0.3 ml of the leech saliva (diluted with saline 1:4) was injected intravenously 2-4 hrs before injection of human serum. Thrombous formation was diminished by 40% when time interval was elongated to 24-28 hrs. Antithrombotic effect does not depend on the antithrombin activity of hirudin. It slightly decreased in case of oral administration and increased after the multiple intravenous injections or oral administration.Blood from the leech intestinal tract and other preparations from the leeches exhibit less distinct antithrombotic effect than the salivatory gland secretion.
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Larsen, Melinda, Riffard Jean-Gilles, David Soscia, Sharon Sequeira, Michael Melfi, Anand Gadre, and James Castracane. "Development of Nanofiber Scaffolds for Engineering an Artificial Salivary Gland." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13372.

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There is currently a significant clinical need for artificial salivary glands as a therapeutic option for patients suffering from xerostomia. To achieve unidirectional fluid secretion, the epithelial acinar cells must establish and maintain polarity by partitioning the plasma membrane into distinct apical and basolateral membrane surfaces to achieve unidirectional fluid secretion. Establishment and maintenance of epithelial acinar cell polarity has been difficult to achieve in vitro, and yet is critical saliva secretion in an engineered salivary gland. Physical properties of the scaffold provided to epithelial cells will likely influence their ability to differentiate and achieve apical-basal polarity. We have engineered nanofiber matrices using the biocompatible polymer, PLGA (poly-L-lactic-co-glycolic acid) having differing topology and organization and documented the structure of these scaffolds using SEM. We evaluated the effects of several factors on epithelial cell attachment, self-organization, and apico-basal polarity on the scaffolds using confocal microscopy to examine expression and organization of apical tight junction proteins, ZO-1 and claudins, and basal markers, such as integrin α6 and the ECM protein fibronectin. The surface of the nanofiber matrix was functionalized with chemically-linked ligands to further optimize apical-basal polarity. These studies will identify an optimal scaffold for future use in an engineered functional salivary gland construct.
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Schubert, Adrian D., Evgeny Izumchenko, Piotr T. Wysocki, David Sidransky, and Mariana Brait. "Abstract 734: Improved detection of salivary glands’ RNA markers in saliva samples." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-734.

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de Souza, Fabrício TA, Carolina C. Gomes, Luiz Armando De Marco, Elisa C. Siqueira, Samuel M. Costa, Jeane F. Correia-Silva, and Ricardo S. Gomez. "Abstract 3297: Cell phone use and cytokines expression in saliva of the parotid glands." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3297.

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Baskova, I., and G. Nikonov. "LEECH PROSTAGLANDINS AND THE ENZYME DESTAB ILASE AS THROMBOLYTIC AGENTS OF THE PREPARATIONS FROM THE MEDICINAL LEECHES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643037.

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The thrombolytic effect of the leeching of thromboflebits has been well known from the ancient time. It is provided by the propertiesof the salivary gland secretion though leech saliva does not show proteolytic activity and does not activate plasminogen to plasmin. Butin leech saliva we have found the enzyme destabilase (isopeptidase-glutaminase) which hydrolyze the crosslinked fibrin. This mechanism can be the basis of a new type of fibrinolysis. We have observed the high affinity of destabilase to fibrin that provides the dissolutionof thrombous in circulating citrate blood in experiments in vitro. The high affinity of destabilase to fibrin correlates with its high ability to bound L-lysine, which inhibits isopeptidase and glutaminase activity of destabilase. Using radioimmunoassay for 6-keto-PgF1 we have found prostaglandins in saliva and other preparations from the medicinal leeches:3400 pg/ml of leech saliva322 pg/mg of protein (the whole leeches extract)351 pg/mg of protein (the head region extract)63 pg/mg of protein (blood from the intestinal tract)But the leech prostaglandins in contrast to 6-keto-PgF1 has Strongly inhibited platelets aggregation stimulated by thrombin. The leech prostaglandins stimulate thrombolysis in rats after intravenous injection or oral administration. We have supposed that thrombolytic effect of leech prostaglandins is induced by the release of tissue plasminogen activator from vessel wall.In the experiments on rats it has been shown that thrombolytic effect of leech saliva and preparations from the medicinal leeches is provided by the summary effect of the leech prostaglandins and the enzyme destabilase. After the extraction of prostaglandins by ethylacetate thrombolytic effect is diminished by 4O per cent.
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Gomez, Ricardo S., Elisa C. Siqueira, Fabrício Tinôco A. Souza, Efigênia F. Ferreira, Renan P. Souza, Eitan Friedman, Marcus V. Gomez, and Carolina C. Gomes. "Abstract 4067: Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4067.

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Burghartz, M., Jan-Constantin Kölmel, I. Fiz, S. Hackenberg, D. Taxis, and C. Sittel. "Whole salivary flow rate and composition of saliva in patients with a benign tumor of the parotid gland." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711428.

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Burghartz, M., J.-C. Kölmel, I. Fiz, D. Taxis, S. Hackenberg, and C. Sittel. "Whole salivary flow rate and composition of saliva in patients with a benign tumor of the parotid gland." In 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1728922.

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Hagemann, J., T. Ertongur-Fauth, P. Scholz, S. Strieth, J. Künzel, and S. Becker. "Identification of new molecular targets and small molecule compounds to modulate saliva secretion for experimental treatment of salivary gland pathologies." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1641002.

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Lazaridis, N., A. Murino, F. Solonos, E. Athanasiadou, A. Podesta, R. Raymond, N. Koukias, et al. "SALINE-IMMERSION THERAPEUTIC ENDOSCOPY (SITE) COMBINED WITH ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) OF A RARE CAUSE OF INTUSSUSCEPTION: A GIANT BRUNNER GLAND ADENOMA." In ESGE Days. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1704843.

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