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1

Banc, Ana, and Stefania Bianchi Marzoli. "Parapapillary atrophy in optic neuropathies: Histology and clinical relevance." European Journal of Ophthalmology 32, no. 1 (2021): 95–101. http://dx.doi.org/10.1177/11206721211060655.

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Parapapillary atrophy is one of the parameters of the optic nerve head area which are assessed during the ophthalmoscopic examination particularly useful to characterize glaucomatous optic neuropathy. Optical coherence tomography evaluation provides high-resolution images of the optic nerve head and surrounding area, and can be used to study parapapillary atrophy. Different parapapillary atrophy zones were described depending on their histological features and research has been conducted to investigate the possible association between the presence and/ or size of parapapillary atrophy zones an
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2

Bajracharya, Kabindra, Prachand Gautam, Sanjeeb Kumar Yadav, and Nirsara Shrestha. "EPIDEMIOLOGY AND CAUSES OF OPTIC ATROPHY IN GENERAL OUTPATIENT DEPARTMENT OF LUMBINI EYE INSTITUTE." Journal of Universal College of Medical Sciences 3, no. 2 (2016): 26–29. http://dx.doi.org/10.3126/jucms.v3i2.14287.

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INTRODUCTION: Optic atrophy is usually applied to the condition of the disc following degeneration of the optic nerve. The present study was done to explore the epidemiology and causes of optic atrophy. MATERIAL AND METHODS: A cross-sectional study of 100 cases of optic atrophy patients with convenience sampling was conducted from 1 July 2012 to 23 September 2012. Clinical history was taken including demography. Visual acuity was taken, pupillary reaction tested and posterior segment examined. Optic atrophy was diagnosed by optic disc examination with slit lamp bio-microscopy with aid of 90D l
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3

Kavita, Patil, Mahantgol Rajeshwari, Badad Shruti, Venkata Jahnavi Sana, and Haritha.V. "Optic Atrophy in Rural North Karnataka: A Retrospective Study of Etiological Patterns." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 1004–7. https://doi.org/10.5281/zenodo.14063763.

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<strong>Background:</strong>&nbsp;Optic atrophy is an end stage result of various pathological conditions affecting the visual pathway anywhere from retina to lateral geniculate body. Ophthalmoscopically classified as primary, secondary, consecutive and glaucomatous. It is important to find the underlying etiology and treat at the earliest in order to prevent complete loss of visual function and improve quality of life.&nbsp;<strong>Methodology:</strong>&nbsp;A retrospective observation study included rural population of north Karnataka, who were diagnosed with optic atrophy during the period
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4

Naveen, Sirohi, Kumar Jitendra, and Kumar Puneet. "Compressive and Glaucomatous Optic Neuropathy: A Comparative Study." PJSR 10, no. 2 (2017): 1–7. https://doi.org/10.5281/zenodo.8242655.

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This research was aimed to study the etiology of optic atrophy and comparison of optic disc morphology between compressive and glaucomatous optic atrophy. It included 72 cases of optic atrophy admitted in Maharani Laxmi Bai Medical College, Jhansi between January 2016 to May 2017. Assessment of present complaints, examination of the eyes, visual acuity, refraction, perimetry, Optical Coherence Tomography(OCT) and slit lamp examination was done. The quantitative parameters of Optic Nerve Head (ONH) structure were compared using the Spectralis OCT with an enhanced depth imaging method. Out of 72
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5

Lee, Andrew G. "Differentiating glaucomatous from nonglaucomatous optic atrophy." Ophthalmology 106, no. 5 (1999): 855. http://dx.doi.org/10.1016/s0161-6420(99)10109-x.

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Abbas, Shakila, Sonia Abdul Sammad, Mariyam Akhtar, Syeda Tasneem Zahra, Syeda Najam Gulzar, and Ayesha Kiran. "Assessment of Optic Nerve Changes in Patients Receiving Anti-Tuberculosis Drugs at Different Time Interval." Journal of Bahria University Medical and Dental College 11, no. 03 (2022): 152–56. http://dx.doi.org/10.51985/jbumdc2021125.

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Objectives: To assess optic nerve changes in patients receiving anti-tuberculosis drugs and to assess optic nerve changes at different time intervals of therapy. Study design and settings: Descriptive cross-sectional study was conducted from August 2021 to November 2021 in Madinah Teaching Hospital, Faisalabad. Methodology: 200 eyes of 100 patients receiving anti-tuberculosis therapy since 2-month, 4-month, 6 month and 8 months were taken. Patients did not have any systemic disease other than Tuberculosis. Indirect Ophthalmoscopy was performed to assess changes in fundus and optic nerve head.
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7

Jiramongkolchai, Kim, Sharon F. Freedman, and Mays A. El-Dairi. "Retinal changes in pediatric glaucomatous and non-glaucomatous optic atrophy." Journal of American Association for Pediatric Ophthalmology and Strabismus 19, no. 4 (2015): e12-e13. http://dx.doi.org/10.1016/j.jaapos.2015.07.018.

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8

Yusupov, Azamat, Muyassar Khamitovna Karimova, and Mastona Zakirkhodzhayeva. "COMPARATIVE ANALYSIS OF TONOMETRY METHODS." UZBEK MEDICAL JOURNAL Special issue, no. 3 (2021): 21–24. http://dx.doi.org/10.26739/2181-0664-2021-si-3-4.

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The principles of glaucoma diagnostics are based on the triad of symptoms -the excess of IOP over the tolerant level, changes in the visual field, primarily in the Bjerrum zone, and also on glaucomatous excavation of the optic nerve head. It should be recognized that the IOP level is the only proven risk factor for the progression of glaucomatous optic nerve atrophy and, at the same time, the only factor that we can influence. That is why the determination of IOP is of great importance in diagnosis and is the basis for evaluating the effectiveness of glaucoma treatment.Keywords: IOP (intraocul
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9

Yusupov, Azamat, Muyassar Khamitovna Karimova, and Mastona Zakirkhodzhayeva. "COMPARATIVE ANALYSIS OF TONOMETRY METHODS." UZBEK MEDICAL JOURNAL Special issue, no. 3 (2021): 21–24. http://dx.doi.org/10.26739/2181-0664-2021-si-3-4.

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The principles of glaucoma diagnostics are based on the triad of symptoms -the excess of IOP over the tolerant level, changes in the visual field, primarily in the Bjerrum zone, and also on glaucomatous excavation of the optic nerve head. It should be recognized that the IOP level is the only proven risk factor for the progression of glaucomatous optic nerve atrophy and, at the same time, the only factor that we can influence. That is why the determination of IOP is of great importance in diagnosis and is the basis for evaluating the effectiveness of glaucoma treatment.Keywords: IOP (intraocul
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10

Mitaliben, M. Prajapati, and I. Dass Radha. "Parallel Study of Hypertensive (Non-Glaucomatous) and Glaucomatous Patients for Optic Disc Parameters." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 645–48. https://doi.org/10.5281/zenodo.12734689.

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<strong>Introduction:&nbsp;</strong>Glaucoma is a type of neurodegenerative disease characterized by morphological variations at the position of the optic nerve head (ONH) or retinal nerve fiber layer (RNFL) as well as damage to the visual field. Assessment of the diurnal fluctuations in IOP and MOPP is clinically relevant in glaucoma patients. Systemic hypertension, as such, may directly damage the small vessels of the optic disc and increase the risk of glaucoma.&nbsp;<strong>Material and Methods:&nbsp;</strong>This is a cross-sectional observational study done with 50 patients, carried out
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11

Jonas, Jost B., Frank-Michael Z�ch, and Gottfried O. H. Naumann. "Dark adaptation in glaucomatous and nonglaucomatous optic nerve atrophy." Graefe's Archive for Clinical and Experimental Ophthalmology 228, no. 4 (1990): 321–25. http://dx.doi.org/10.1007/bf00920055.

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12

Jonas, Jost B., Rahul A. Jonas, Shefali B. Jonas, and Songhomitra Panda-Jonas. "Myopia and Other Refractive Error and Their Relationships to Glaucoma Screening." Journal of Glaucoma 33, Suppl 1 (2024): S45—S48. http://dx.doi.org/10.1097/ijg.0000000000002407.

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Précis: A large disk, a large parapapillary delta zone and a long axial length may be used as screening criteria to detect glaucomatous optic neuropathy in highly myopic eyes. Purpose: To describe aspects for screening of glaucomatous optic neuropathy in dependence of refractive error, under special consideration of high myopia. Methods/Results: Studies on the anatomy of the myopic optic nerve head and results of investigations on the relationship between glaucomatous optic neuropathy and axial myopia were included. Conclusions: In the range from hyperopia to moderate myopia, refractive error
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13

Zhang, Zi-Qiao, Sen-Yuan Chen, and Xu Zhang. "Mitochondrial dysfunction in glaucomatous degeneration." International Journal of Ophthalmology 16, no. 5 (2023): 811–23. http://dx.doi.org/10.18240/ijo.2023.05.20.

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Glaucoma is a kind of optic neuropathy mainly manifested in the permanent death of retinal ganglion cells (RGCs), atrophy of the optic nerve, and loss of visual ability. The main risk factors for glaucoma consist of the pathological elevation of intraocular pressure (IOP) and aging. Although the mechanism of glaucoma remains an open question, a theory related to mitochondrial dysfunction has been emerging in the last decade. Reactive oxygen species (ROS) from the mitochondrial respiratory chain are abnormally produced as a result of mitochondrial dysfunction. Oxidative stress takes place when
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14

Song, Min Kyung, Kyung Rim Sung, Joong Won Shin, Junki Kwon, Ji Yun Lee, and Ji Min Park. "Progressive change in peripapillary atrophy in myopic glaucomatous eyes." British Journal of Ophthalmology 102, no. 11 (2018): 1527–32. http://dx.doi.org/10.1136/bjophthalmol-2017-311152.

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AimTo evaluate the progressive change in peripapillary atrophy (PPA) according to its shape and to explore the relationship between PPA progression and glaucoma worsening in myopic eyes.MethodsA total of 159 eyes of 159 patients with myopic (axial length (AXL) &gt;24 mm) glaucoma (mean follow-up 4.4 years, 35 eyes with minimal PPA, 40 concentric-type PPA eyes (&gt;270° around the optic disc) and 84 eccentric-type PPA eyes (&lt;270°)) were included. Sequential stereoscopic colour optic disc photographs were evaluated to qualitatively determine PPA progression. Factors associated with PPA progre
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15

AKDAN BİLEN, Rabiatül Büşra. "Optic Disc Features in Pathological Myopia And Myopic Optic Neuropathy." Güncel Retina Dergisi (Current Retina Journal) 9, no. 4 (2024): 303–7. http://dx.doi.org/10.37783/crj-0482.

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Pathological myopia is defined as excessive axial elongation accompanied by various structural changes in the fundus and optic disc, leading to a decrease in best-corrected visual acuity. Today, with the widespread use of optical coherence tomography (OCT) in ophthalmology, optic disc pathologies have been identified in addition to fundus findings. Due to axial elongation, large optic disc, tilted optic disc, retinal nerve fiber changes, peripapillary atrophy, intachoroidal cavitation and peripapillary-prelaminar schisis are observed. Optic neuropathy occurs in some cases secondary to all thes
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16

Egiazarova, A. G., and I. P. Shurygina. "Differential-diagnostic approach in assessing the nature of the course of partial atrophy of the optic nerve." POINT OF VIEW. EAST – WEST, no. 3 (September 28, 2021): 64–65. http://dx.doi.org/10.25276/2410-1257-2021-3-64-65.

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Purpose. To determine the diagnostic criteria for the progressive nature of the course of non-glaucomatous etiology of ONA according to the data of electrophysiological and Doppler studies. Material and methods. In accordance with the purpose of the study, 3 groups were formed of 95 patients aged 37 to 72 years, (average age 56±9 years), 53 of them were men and 42 were women. Clinical data of three clinical groups were compared, of which the first group with stationary ONA, the second with progressive ONA, and the third control group, without pathology of the retina and optic nerve. Results. I
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17

Hata, Masayuki, Kazuaki Miyamoto, Akio Oishi, et al. "Comparison of Optic Disc Morphology of Optic Nerve Atrophy between Compressive Optic Neuropathy and Glaucomatous Optic Neuropathy." PLoS ONE 9, no. 11 (2014): e112403. http://dx.doi.org/10.1371/journal.pone.0112403.

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18

Seo, Jeong Hyun, and Seung Hyen Lee. "Variability in Optic Nerve Head Morphology in High Axial Myopia and Its Association with Glaucoma." Journal of the Korean Ophthalmological Society 65, no. 10 (2024): 665–74. http://dx.doi.org/10.3341/jkos.2024.65.10.665.

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Purpose: To investigate optic disc morphology in high axial myopia and its associations with the deep-layer structure of the optic disc using optical coherence tomography and glaucoma.Methods: We retrospectively reviewed the medical records of 69 eyes (33 normal and 36 glaucomatous eyes) with an axial length of 26-27 mm. The eyes were categorized into two groups based on the optic disc tilt ratio (≥ 1.3 or &lt; 1.3). Characteristics of optic disc morphology, including lamina cribrosa depth, peripapillary atrophy width, and Bruch’s membrane opening area, were compared between the two groups. Fu
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19

Chuprov, A. D., S. M. Kim, N. V. Korshunova, A. V. Fomenko, Y. S. Kuvaitseva, and I. S. Ryvkin. "Complex Therapy Response in Treatment of Partial Optic Atrophy of Various Origins." Medicina 8, no. 2 (2020): 1–9. http://dx.doi.org/10.29234/2308-9113-2020-8-2-1-9.

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Regional drugs injection is а promising method of partial optic atrophy treatment. The therapy involves the introduction of drugs into the microcirculation region on the side of the affected organ, in the area corresponding to the topographic projection of the lymph node. Purpose: To evaluate the effectiveness of treatment of partial optic atrophy of various origins using regional combination therapy. Material and Methods: Complex therapy was applied in hospital environment of The S. Fyodorov Eye Microsurgery Federal State Institution in treatment of 38 patients (38 eyes) with partial optic at
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20

Jonas, J. B., U. Mayer, and W. M. Budde. "Ocular Findings in Cerebro-Oculo-Facial-Skeletal Syndrome (Pena-Shokeir-II Syndrome)." European Journal of Ophthalmology 13, no. 2 (2003): 209–11. http://dx.doi.org/10.1177/112067210301300215.

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Purpose To report the ocular findings in cerebro-oculo-facial-skeletal syndrome or Pena-Shokeir-II syndrome. Methods Case report. Results A five-month-old male infant presented with bilateral posterior polar cataract, microphthalmos, nystagmus, and marked non-glaucomatous optic nerve atrophy. Systemic abnormalities such as microcephaly, micrognathia, flexion contractures of the elbows and knees, hypotonic musculature, and failure to thrive, with pronounced statomotor retardation, led to the diagnosis of cerebro-oculo-facial-skeletal syndrome or Pena-Shokeir-II syndrome. Cataract surgery did no
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21

Kazennova, I. A., A. D. Chuprov, A. E. Voronina, and A. N. Kazennov. "Microperimetry in the diagnosis of early stages glaucoma." Modern technologies in ophtalmology, no. 2 (June 15, 2021): 170–76. http://dx.doi.org/10.25276/2312-4911-2021-2-170-176.

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Purpose. To increase the efficiency of diagnostics of glaucomatous process in the early stages using microperimetry. Materials and methods. We examined 15 patients (30 eyes) aged 43-71 years (average age 62 years) with the initial stage of POAG, the duration of the disease was 8-36 months. The control group consisted of 10 patients (20 eyes), somatically healthy individuals without concomitant ophthalmopathology. In addition to standard research methods, the following were additionally carried out: optical coherence tomography (OCT) of the optic nerve disk, macular OCT for analyzing the thickn
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22

Bajracharya, Kabindra, Kriti Joshi, Anjita Hirachan, Lily Myint, and Hari Bahadur Thapa. "Profile of optic atrophy presented in the neuro-ophthalmology department of the tertiary eye care center." Asian Journal of Medical Sciences 14, no. 8 (2023): 152–56. https://doi.org/10.71152/ajms.v14i8.3680.

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Background: Optic atrophy is a clinical presentation in which the optic disc appears pale due to irreversible damage of retinal ganglion cells and axons in the anterior visual pathway. Aims and Objectives: The aim of this study was to determine the profile of optic atrophy cases in the neuro-ophthalmology department of a tertiary eye hospital and to identify the common causes and associated visual impairments. Materials and Methods: This was a cross-sectional study conducted from January 2021 to December 2021, using convenience sampling method for data collection. Demographic data, medical his
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Bajracharya, Kabindra, Kriti Joshi, Anjita Hirachan, Lily Myint, and Hari Bahadur Thapa. "Profile of optic atrophy presented in the neuro-ophthalmology department of the tertiary eye care center." Asian Journal of Medical Sciences 14, no. 8 (2023): 152–56. http://dx.doi.org/10.3126/ajms.v14i8.52894.

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Background: Optic atrophy is a clinical presentation in which the optic disc appears pale due to irreversible damage of retinal ganglion cells and axons in the anterior visual pathway. Aims and Objectives: The aim of this study was to determine the profile of optic atrophy cases in the neuro-ophthalmology department of a tertiary eye hospital and to identify the common causes and associated visual impairments. Materials and Methods: This was a cross-sectional study conducted from January 2021 to December 2021, using convenience sampling method for data collection. Demographic data, medical his
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24

Upadhyay, Pratibha, and Shamsa Fiaz. "16. Treatment of glaucomatous optic atrophy through ayurveda : A case study." Journal of Ayurveda and Integrative Medicine 9, no. 2 (2018): S14. http://dx.doi.org/10.1016/j.jaim.2018.02.059.

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25

Özkan Aksoy, Nilgün, Burçin Çakır, Sedat Özmen, Erkan Çelik, Tural Babashli, and Gürsoy Alagöz. "The increased epiretinal membrane frequency in patients with glaucomatous optic atrophy." Journal of Glaucoma and Cataract 18, no. 2 (2023): 67. http://dx.doi.org/10.37844/glau.cat.2023.18.10.

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26

Saidov, Temur. "Clinical And Functional Effectiveness Of Endonasal Electrophoresis In Combination With Electrostimulation In Complex Therapy Of Glaucomatous Optic Neuropathy." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 03 (2021): 12–19. http://dx.doi.org/10.37547/tajmspr/volume03issue03-02.

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The aim of the study was the clinical and functional assessment of the complex treatment of glaucomatous optic neuropathy with the administration of the drug tanakan in the form of endonasal electrophoresis in combination with electrical stimulation according to IST and ultrasound Doppler mapping. We examined 43 (74 eyes) patients with GON aged from 58 to 76 years. The results of the study showed that this method effectively delays the development of optic nerve atrophy and, along with the improvement of visual functions, lengthens the positive effect of the main treatment, which was confirmed
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27

Michelson, Georg, Tobias Engelhorn, Simone Waerntges, and Arnd Doerfler. "Diffusion Tensor Imaging for In Vivo Detection of Degenerated Optic Radiation." ISRN Ophthalmology 2011 (December 27, 2011): 1–6. http://dx.doi.org/10.5402/2011/648450.

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Glaucomatous optic nerve atrophy may continue to the linked optic radiation by transneuronal degeneration, as described in animal models of glaucoma. In vivo visualization of the visual pathway represents a new challenge in the field of ophthalmology. We present a new approach for illustration of the optic radiation by diffusion tensor imaging (DTI) based on magnetic resonance imaging (MRI). The DTI was established by use of a 3T high-field scanner. The case of a patient with primary open-angle glaucoma is opposed to this one of a healthy subject to demonstrate the visible rarefication of the
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Astakhov, Yu S., S. N. Tultseva, and A. I. Titarenko. "The role of endothelium dysfunction in the pathogenesis of vascular ocular diseases." Regional blood circulation and microcirculation 15, no. 4 (2016): 5–16. http://dx.doi.org/10.24884/1682-6655-2016-15-4-5-16.

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Vascular endothelium plays the key role in the control of vascular tone due to release of vasoactive substances. Reduction of retinal, choroidal and optic nerve head blood flow is above all a result of misbalance between endothelium-produced vasoconstrictors and vasodilators mainly ET-1 and NO. NO is involved in the maintenance of choroidal, optic nerve head and retinal basal blood flow. Combination of NO deficiency and overproduction of ET-1 is accompanied by diabetic retinopathy, glaucomatous optic nerve atrophy, retinal vascular occlusion and other ocular disease. In the review, the role of
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Kurysheva, N. I., V. Yu Kim, and V. E. Kim. "Peripapillary choriocapillaris blood flow in glaucoma. Part 2. Peripapillary choriocapillaris dropout and its relationship to the progression of glaucomatous optic neuropathy." National Journal glaucoma 23, no. 4 (2024): 54–59. https://doi.org/10.53432/2078-4104-2024-23-4-54-59.

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Choriocapillaris dropout within the beta zone of peripapillary choroidal atrophy is a significant marker in glaucoma diagnosis. This marker is associated with retinal nerve fiber layer thinning, retinal ganglion cell loss, and visual field deterioration. This review highlights data showing a correlation between choriocapillaris blood flow and the progression of glaucomatous optic neuropathy, suggesting that choriocapillaris dropout serves as a vital biomarker for glaucoma progression, and provides literature evidence on how choriocapillaris blood flow changes relate to glaucoma treatment.
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Nakano, Eri, Masayuki Hata, Akio Oishi, et al. "Quantitative comparison of disc rim color in optic nerve atrophy of compressive optic neuropathy and glaucomatous optic neuropathy." Graefe's Archive for Clinical and Experimental Ophthalmology 254, no. 8 (2016): 1609–16. http://dx.doi.org/10.1007/s00417-016-3366-2.

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Sonas, Jost B., Martin C. Fernandez, and Cottfried O. H. Naumann. "Glaucomatous Optic Nerve Atrophy in Small Discs with Low Cup-to-disc Ratios." Ophthalmology 97, no. 9 (1990): 1211–15. http://dx.doi.org/10.1016/s0161-6420(90)32434-x.

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Gurung, Jamuna, Rakshya Pant Sitoula, and Anjani Kumar Singh. "Profile of Secondary Glaucoma in a Tertiary Eye Hospital of Eastern Nepal." Nepalese Journal of Ophthalmology 13, no. 1 (2021): 98–103. http://dx.doi.org/10.3126/nepjoph.v13i1.28968.

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Background: To determine the clinical profile and causes of various types of secondary glaucoma.&#x0D; Materials and methods : This was a hospital-based cross-sectional study conducted in a tertiary eye hospital of eastern Nepal from 1st June to 30th November, 2017. Patients who met the criteria for secondary glaucoma underwent detailed ophthalmic examination.&#x0D; Results : Out of 7079 patients diagnosed with glaucoma or glaucoma suspects, 528 (7.4%) had secondary glaucoma. The mean age at presentation was 52 ± 17 years with male to female ratio of 1.5:1. The most common cause was lens induc
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Negiloni, Kalpa, Ronnie Jacob George, Sridharan Sudharshan, and Shwetha Tripathi. "Successful management of intralenticular Ozurdex injection causing cataract and intractable glaucoma." Asian Journal of Ophthalmology 17, no. 2 (2020): 216–21. http://dx.doi.org/10.35119/asjoo.v17i2.575.

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A 50-year-old female presented with profound vision loss and was previously advised injection Ozurdex in the left eye. In the left eye, the anterior chamber was quiet, intraocular pressure (IOP) was 58 mmHg and cataractous changes were noted with Ozurdex implant inside the lens substance. The left eye had glaucomatous cupping (0.9:1 CDR), bipolar rim thinning, inferior notch and healed choroiditis. The patient underwent phacoemulsification, trabeculectomy and mitomycin-C in the left eye. Visual acuity improved and IOP was under control. Although Ozurdex is effective, there are reports of compl
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34

Reis, Alexandre SC, Andrew Toren, and Marcelo T. Nicolela. "Clinical Optic Disc Evaluation in Glaucoma." European Ophthalmic Review 06, no. 02 (2012): 92. http://dx.doi.org/10.17925/eor.2012.06.02.92.

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Examination of the optic nerve head (ONH) is essential for the diagnosis of glaucoma and assessment of its progression. Slit-lamp biomicroscopy with a handheld lens is the best method of ONH examination since it provides good stereopsis and magnification. ONH stereo photographs are complementary and may identify findings missed on slit-lamp examination. As a result of its subjective nature, a standardised approach should be utilised for clinical ONH evalaution, including an assessment of ONH size and careful evaluation of the neuroretinal rim contour, the presence of retinal nerve fibre layer
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Ju, Won-Kyu, Myoung Sup Shim, Keun-Young Kim, et al. "Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization." Oxidative Medicine and Cellular Longevity 2019 (November 6, 2019): 1–16. http://dx.doi.org/10.1155/2019/8060962.

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Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic nerve head (ONH) have a role in glaucomatous neurodegeneration. Here, we investigate the impact of activation of cyclic adenosine 3′,5′-monophosphate (cAMP)/protein kinase A (PKA) pathway on mitochondrial dynamics of ONH astrocytes exposed to oxidative stress. ONH astrocytes showed a significant loss o
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Sun, Jinyang, Fangjun Luan, and Hanhui Wu. "Optic Disc Segmentation by Balloon Snake with Texture from Color Fundus Image." International Journal of Biomedical Imaging 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/528626.

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A well-established method for diagnosis of glaucoma is the examination of the optic nerve head based on fundus image as glaucomatous patients tend to have larger cup-to-disc ratios. The difficulty of optic segmentation is due to the fuzzy boundaries and peripapillary atrophy (PPA). In this paper a novel method for optic nerve head segmentation is proposed. It uses template matching to find the region of interest (ROI). The method of vessel erasing in the ROI is based on PDE inpainting which will make the boundary smoother. A novel optic disc segmentation approach using image texture is explore
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Yulia Puspita Sari and Najwa Khalisa. "Primary Open Angle Glaucoma." Jurnal Ilmiah Kedokteran dan Kesehatan 2, no. 3 (2023): 48–57. http://dx.doi.org/10.55606/klinik.v2i3.1880.

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Glaucoma is a group of neurooptic diseases that has one feature in the form of progressive optic nerve damage caused by increased intraocular pressure, characterized by abnormalities or atrophy of the optic nerve papillae, the presence of glaucomatous excavations, as well as visual field disturbances and blindness. This pattern of peripheral vision loss can also be a distinguishing characteristic from other forms of vision loss. Glaucoma is the second leading cause of blindness for more than 70 million people worldwide. Bilateral blindness occurs in an estimated 10%. In Indonesia, the prevalen
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De Moraes, Carlos Gustavo, Scott Ketner, Christopher C. Teng, et al. "Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy." Documenta Ophthalmologica 123, no. 1 (2011): 43–50. http://dx.doi.org/10.1007/s10633-011-9280-3.

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Sandhu, Simrenjeet, Chris Rudnisky, Sourabh Arora, et al. "Compressed 3D and 2D digital images versus standard 3D slide film for the evaluation of glaucomatous optic nerve features." British Journal of Ophthalmology 102, no. 3 (2017): 364–68. http://dx.doi.org/10.1136/bjophthalmol-2017-310447.

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SynopsisClinicians can feel confident compressed three-dimensional digital (3DD) and two-dimensional digital (2DD) imaging evaluating important features of glaucomatous disc damage is comparable to the previous gold standard of stereoscopic slide film photography, supporting the use of digital imaging for teleglaucoma applications.Background/aimsTo compare the sensitivity and specificity of 3DD and 2DD photography with stereo slide film in detecting glaucomatous optic nerve head features.MethodsThis prospective, multireader validation study imaged and compressed glaucomatous, suspicious or nor
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Choi, Seunghwan, Soo-Ho Choi, Tonking Bastola, et al. "AIBP Protects Müller Glial Cells Against Oxidative Stress-Induced Mitochondrial Dysfunction and Reduces Retinal Neuroinflammation." Antioxidants 13, no. 10 (2024): 1252. http://dx.doi.org/10.3390/antiox13101252.

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Glaucoma, an optic neuropathy with the loss of retinal ganglion cells (RGCs), is a leading cause of irreversible vision loss. Oxidative stress and mitochondrial dysfunction have a significant role in triggering glia-driven neuroinflammation and subsequent glaucomatous RGC degeneration in the context of glaucoma. It has previously been shown that apolipoprotein A-I binding protein (APOA1BP or AIBP) has an anti-inflammatory function. Moreover, Apoa1bp−/− mice are characterized by retinal neuroinflammation and RGC loss. In this study, we found that AIBP deficiency exacerbated the oxidative stress
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Sharma, R. L., Vinay Gupta, Kalpana Sharma, Deepti Parmar, Shashi Sharma, and YP Ratna. "Live eye donor - two rare cases in two different situations." IP International Journal of Ocular Oncology and Oculoplasty 7, no. 3 (2021): 312–15. http://dx.doi.org/10.18231/j.ijooo.2021.065.

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The promotion of eye donation has always been a challenging task for any individual or institute, and hence there is more demand and less supply of corneal tissue. Legally corneal donations are usually cadaveric allograft. But living eye donation though rare is sometimes done. We report two rare cases in which the cornea of the first case was retrieved from living donor, who had traumatic expulsion of right eye in road traffic accident. So the cornea of this living donor after enucleation of globe was utilized to restore the vision of another corneal blind person. The second case was a patient
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Butt, Sameer, and Adèle Ehongo. "Interpupillary Distance and Peripapillary Myopic Changes: A Pilot Study in a Glaucomatous Cohort." Journal of Clinical Medicine 14, no. 14 (2025): 4895. https://doi.org/10.3390/jcm14144895.

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Background/Objectives: Myopia is associated with peripapillary changes, namely, gamma peripapillary atrophy (γPPA) and optic disc ovalization, estimated by the ovality index (OI). These changes have been suggested to be promoted by adduction. Recent studies highlight that near reading significantly contributes to the development and progression of myopia and that the interpupillary distance (IPD) influences vergence amplitudes. While both adduction and convergence are involved during near reading, a potential link between IPD and myopic peripapillary changes has not yet been explored. We, ther
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Önol, Merih, Şengül C. Özdek, and Berati Hasanreisoğlu. "Improved visual acuity in an eye with glaucomatous optic atrophy following loss of the good eye." Eye 14, no. 3 (2000): 408–9. http://dx.doi.org/10.1038/eye.2000.107.

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Puthalath, Athul Suresh, Ajai Agrawal, Rimpi Rana, and Ramanuj Samanta. "A case of Axenfeld-Rieger syndrome (ARS) with asymmetric ocular phenotypes and left glaucomatous optic atrophy." BMJ Case Reports 13, no. 7 (2020): e237224. http://dx.doi.org/10.1136/bcr-2020-237224.

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45

Lagre`ze, Wolf A., Mirjam Gaggl, Matthias Weigel, et al. "Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy." Investigative Opthalmology & Visual Science 50, no. 9 (2009): 4223. http://dx.doi.org/10.1167/iovs.08-2683.

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46

Coutureau, Tibaut, Jacqueline Butterworth, Damien Biotti, Pierre Fournié, Vincent Soler, and Fanny Varenne. "Microcystic Macular Edema Caused by Non-Glaucomatous Optic Atrophy: A Single-Center, Retrospective, Cohort Study in France." Vision 8, no. 3 (2024): 52. http://dx.doi.org/10.3390/vision8030052.

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Optic Atrophy (OA) can be associated with the development of microcystic macular edema (MME) in the perifoveal retinal inner nuclear layer (INL). We aimed here to retrospectively determine the prevalence of MME in patients with non-glaucomatous OA in our tertiary ophthalmology department between 2015 and 2020. We then examined how MME affected the thicknesses of the different retinal layers and the differences in demographic and clinical characteristics between those patients who developed MME and those who did not. A total of 643 eyes (429 patients) were included (mean age 45.9 ± 17.8 years,
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Lehmann, M. V., C. Y. Mardin, P. Martus, and A. Bergua. "3D vs 2D qualitative and semiquantitative evaluation of the glaucomatous optic disc atrophy using computer-assisted stereophotography." Eye 22, no. 5 (2007): 628–35. http://dx.doi.org/10.1038/sj.eye.6702690.

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Fraenkl, Stephan Alexander, Quentin Simon, Yeni Yucel, et al. "Impact of cerebral hypoperfusion–reperfusion on optic nerve integrity and visual function in the DBA/2J mouse model of glaucoma." BMJ Open Ophthalmology 7, no. 1 (2022): e001078. http://dx.doi.org/10.1136/bmjophth-2022-001078.

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ObjectiveOne of the most important risk factors for developing a glaucomatous optic neuropathy is elevated intraocular pressure. Moreover, mechanisms such as altered perfusion have been postulated to injure the optical path. In a mouse model, we compare first negative effects of cerebral perfusion/reperfusion on the optic nerve structure versus alterations by elevated intraocular pressure. Second, we compare the alterations by isolated hypoperfusion-reperfusion and isolated intraocular pressure to the combination of both.Methods and analysisMice were divided in four groups: (1) controls; (2) p
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Dolzhikov, Aleksandr A., Olga A. Shevchenko, Anna S. Pobeda, et al. "Review of a new concept of glaucoma pathogenesis based on the glymphatic theory of cerebrospinal fluid circulation." Research Results in Pharmacology 6, no. 3 (2020): 1–7. http://dx.doi.org/10.3897/rrpharmacology.6.53634.

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General aspects of glaucoma: Glaucoma is a heterogeneous multi-factorial disease that is one of the main causes of blindness, along with degeneration of retinal ganglion cells and optic nerve atrophy. Theories of pathogenesis: There are three theories of glaucoma pathogenesis: biomechanical, vascular, and biochemical. Basic theory of the glymphatic system: The classical knowledge of cerebrospinal fluid circulation has been revised, and in 2012 a new concept of glial-perivascular – glymphatic perfusion of the brain parenchyma was introduced. Due to experimental and clinical studies, it is appro
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50

Dolzhikov, Aleksandr A., Olga A. Shevchenko, Anna S. Pobeda, et al. "Review of a new concept of glaucoma pathogenesis based on the glymphatic theory of cerebrospinal fluid circulation." Research Results in Pharmacology 6, no. (3) (2020): 1–7. https://doi.org/10.3897/rrpharmacology.6.53634.

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General aspects of glaucoma: Glaucoma is a heterogeneous multi-factorial disease that is one of the main causes of blindness, along with degeneration of retinal ganglion cells and optic nerve atrophy. Theories of pathogenesis: There are three theories of glaucoma pathogenesis: biomechanical, vascular, and biochemical. Basic theory of the glymphatic system: The classical knowledge of cerebrospinal fluid circulation has been revised, and in 2012 a new concept of glial-perivascular – glymphatic perfusion of the brain parenchyma was introduced. Due to experimental and clinical studies, it is appro
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