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Dissertations / Theses on the topic 'Glioblastoma multiform (GBM)'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Aljohani, Hashim M. B. S. "Signaling Pathways Associated with Gefitinib Resistance in Glioblastoma Multiforme (GBM)." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406900804.

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2

Frixa, Christophe. "Boronated tetraphenylporphyrins for use in boron neutron capture therapy of cancer." Thesis, University of Bath, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268747.

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3

Alowaidi, Faisal A. N. "Functional Identification of Cripto-1 (TDGF1) Role in Glioblastoma Multiforme." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/366238.

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Glioblastoma multiforme (GBM) is one of the most aggressive tumours and has poor survival rate. The expression of the embryonic stem cell factor Crypto-1 has been documented in most cancer types. More specifically, Cripto-1 expression has recently been correlated with low survival rate of young glioblastoma patients. It has been demonstrated that Cripto-1 controls cell survival and stemness, as well as proliferation and epithelial to mesenchymal transition (EMT). The contribution of Cripto-1 to tumour vascularisation was also reported. Even though Cripto-1 expression and sign

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4

Jilesen, Zachary Keavin. "Discovery and Application of Neoepitopes in an Oncolytic Rhabdovirus Vaccine Approach to Treat Glioblastoma Multiforme." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39688.

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Glioblastoma multiforme is the most common and lethal primary brain tumour in adults. Its aggressive and invasive phenotype makes it resistant to current standards of care, with a patient median survival following treatment of only 14 months. Potent and safe therapeutics are necessary to improve patient prognosis. Globally, efforts are being made in immunotherapies to combat such deleterious tumours. Preliminary work in the Stojdl lab has developed a novel oncolytic virus platform for brain cancer therapy that is non-toxic and exhibits potent anti-tumour efficacy. This platform is based on the

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5

Xie, Yuan. "Modeling glioblastoma heterogeneity to decipher its biology." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278529.

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Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. We have established and characterized a biobank of 48 cell lines derived from GBM patients. The cells were explanted and maintained as adherent cultures in serum-free, defined neural stem cell medium. These GBM cells (GCs) displayed NSC marker expression in vitro, had orth

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6

Anand, Monika. "FUNCTION AND REGULATION OF MATRIX METALLOPROTEINASE-1 IN GLIOBLASTOMA MULTIFORME." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2214.

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Glioblastoma Multiforme (GBM) is an aggressive and fatal cancer of the brain. It is characterized with augmented morbidity and elusion to therapies due in part to the incessant infiltration and spread of tumor cells in normal brain. We investigated the function of Matrix metalloproteinase-1, an important enzyme noted to be responsible for invasion in other cancers, in GBM and its regulation by epidermal growth factor receptor (EGFR) signaling. Previous studies from our laboratory demonstrated elevated levels of MMP-1 in GBM. Further studies indicated the involvement of MMP-1 in GBM invasio

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Waters, Michael R. "RelB acts as a molecular switch to drive chronic inflammation in glioblastoma multiforme (GBM)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4958.

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Inflammation is a homeostatic response to tissue injury or infection, which is normally short- lived and quickly resolves to limit tissue damage. In contrast, chronic inflammation has been linked to a variety of human diseases, including cancers such as glioblastoma multiforme (GBM). GBMs are very aggressive tumors with very low patient survival rates, which have not improved in several decades. GBM tumors are characterized by necrosis and profound inflammation; with cytokines secreted by both GBM cells and the tumor microenvironment. The mechanisms by which chronic inflammation develops and p

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8

Mazumdar, Tapati. "ROLE AND REGULATION OF MYC IN GLIOBLASTOMA MULTIFORME CELL DIFFERENTIATION: IMPLICATION IN TUMOR FORMATION." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1214366273.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed Sept. 28, 2009). Advisor: Saikh Jaharul Haque. Keywords: GBM; Differentiation; Myc; Stat3; GFAP. Includes bibliographical references (p. 153-189).

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9

BUTTA, VALENTINA. "Studio dei potenziali effetti antineoplastici del pioglitazone su cellule staminali tumorali da Glioblastoma Multiforme." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/54504.

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Il glioblastoma multiforme (GBM) è un astrocitoma di IV grado, è il più comune tra i tumori maligni cerebrali. La sopravvivenza media dei pazienti trattati è inferiore a 16 mesi e non è significativamente migliorata in questi ultimi decenni, sottolineando le difficoltà nell’efficace caratterizzazione e trattamento di questo tipo di tumore. L’alta frequenza di recidiva del GBM, il suo elevato potere infiltrante e la resistenza alla radio e chemioterapia rendono urgente lo sviluppo di strategie di trattamento maggiormente efficaci per la cura di questo tumore. La resistenza ai trattamenti conve

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10

MONGIARDI, MARIA PATRIZIA. "Inhibition of telomerase and hypoxia-inducible factor-1 in human glioblastoma multiforme." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/985.

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Il glioblastoma multiforme (GBM), il più comune e aggressivo dei tumori gliali, è composto da una popolazione eterogenea di cellule tumorali astrocitarie scarsamente differenziate. Questi tumori possono svilupparsi dall’evoluzione maligna di un astrocitoma di più basso grado (grado WHO I o II) o da un astrocitoma anaplastico (grado WHO III), ma più frequentemente si manifestano de novo, senza alcuna evidenza di una neoplasia precedente. Il GBM è un tumore paradigmatico nella capacità di indurre neo-angiogenesi, processo necessario per la crescita dei tumori solidi. Le cellule endoteliali del

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11

Nohelty, Susan Rebecca. "Glioblastoma multiforme: Geographic variations in tumor size, treatment options, and survival rate." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/268.

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Glioblastoma multiforme (GBM) is a destructive brain cancer that results in death 12 to 15 months after diagnosis. The purpose of this retrospective study was to determine if variations in tumor size at diagnosis, treatment options, and survival rate occur in GBM patients living in urban and rural areas of the United States. Using the behavior model of health services as the theoretical framework, this study used secondary data sets of GBM cases reported from 1988 to 2011 from the Surveillance, Epidemiology, and End Results program. Tumor size was measured in millimeters; treatment was evaluat

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12

Chou, Nigel Shijie. "Measuring mass changes in single suspended and adherent cells, with applications to personalized medicine in Glioblastoma Multiforme (GBM)." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112498.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 117-119).<br>The increased precision offered by developments in suspended microchannel resonator (SMR) technology opens the possibility for measuring small mass changes in cells. Mass accumulation rate (MAR) measurements in single suspended cells over short periods of time have the potential for characterizing heterogeneous collections of tumorigenic cells and serve as a functional marker for the effects of ant

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13

Tavallai, Seyedmehrad. "Lapatinib and Sorafenib Kill GBM Tumor Cells in a Greater than Additive Manner." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3234.

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Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults, affecting thousands of people worldwide every year, with a life expectancy, post diagnosis of 12 months. Surgery, radiotherapy and chemotherapy together, result in an overall mean survival not exceeding 15 months. Targeted therapeutic agents sorafenib, an oral multi kinase inhibitor, and lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, used in combination have been shown to kill GBM cells be through inhibition of major growth mediating signaling pathways that are frequently over expressed in g

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14

Engelhardt, Martin [Verfasser]. "Analyse der perifokalen Infiltrationszone des Glioblastoma multiforme (GBM) im Vergleich zum Umgebungsödem von Metastasen mittels T2-Mapping / Martin Engelhardt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042996/34.

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15

Duque, Marienela Buendia. "Avaliação do efeito sinérgico do butirato de sodio e tyrphostin AG1478 na proliferação de glioblastoma multiforme." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/157620.

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Introdução: Gliomas são os tumores cerebrais mais frequentes em pacientes com neoplasias de Sistema Nervoso Central (SNC), sendo o Glioblastoma Multiforme (GBM) o mais agressivo e letal deles. Apesar dos esforços na melhoria dos tratamentos atuais, o prognóstico para os pacientes com GBM continua sendo incerto. Sendo necessário o uso de novas estratégias terapêuticas que visem melhorar o manejo dos gliomas malignos. A combinação de terapias que agem nas principais vias de sinalização celular envolvidas na progressão do câncer poderia potencializar o efeito antitumoral das monoterapias. Métodos

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16

Santos, Claudia Januário dos. "Infectividade do Citomegalovírus Humano (HCMV) em células tumorais de Glioblastoma Multiforme (GBM) e efeito do vírus no tratamento quimioterápico in vitro." reponame:Repositório Institucional da UFABC, 2018.

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Orientadora: Profa. Dra. Maria Cristina Carlan da Silva<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, 2018.<br>A relação entre a presença do Citomegalovírus Humano (HCMV) e diversos tipos de tumores tem sido alvo de investigação por décadas, e em especial, em Glioblastoma Multiforme (GBM). O GBM é o mais maligno tumor do Sistema Nervoso Central (SNC), com baixa sobrevida mesmo após o tratamento. Nosso grupo e outros demonstraram a presença do HCMV neste tipo de tumor restrita a uma pequena quantidade de células, além disso, vários mecanismos de a

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17

Baghdadchi, Negin. "CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION." CSUSB ScholarWorks, 2014. https://scholarworks.lib.csusb.edu/etd/93.

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Glioblastoma multiforme (GBM) is the most lethal primary central nervous system tumor, with median survival after diagnosis of less than 12 months because dissemination into the brain parenchyma limits the long-term effectiveness of surgical resection, and because GBM cells are resistant to radiation and chemotherapy. This sad dismal prognosis for patients with GBM emphasizes the need for greater understand of the fundamental biology of the disease. Invasion is one of the major causes of treatment failure and death from glioma, because disseminated tumor cells provide the seeds for tumor recur

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18

Oba, Selay. "Effect of Ion Channels on Intracellular Localization of REV-ERBα in Glioma-Initiating Cells". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446067.

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The number of children and young adolescents diagnosed with cancer is increasing, leading to a need for new therapeutic strategies with diminished neurodegenerative side- effects. This report presents preliminary observations on glioma-initiating cells (GICs) in the way to develop a strategy that induces cell-cycle arrest or quiescence in neural stem cells (NSCs). To test how changes in membrane potential due to pharmacological treatments have effects on localization and levels of REV-ERBα protein, proneural (PN) and mesenchymal (MES) cells were treated with varying concentrations of REV-ERBα

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19

Guhasarkar, Dwijit. "A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation". eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/843.

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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The current standard-of-care treatment including surgery, radiation and temozolomide (TMZ) chemotherapy does not prolong the survival satisfactorily. Here we have tested the feasibility, efficacy and safety of a potential gene therapy approach using AAV as gene delivery vehicle for treatment of GBM. Interferon-beta (IFNβ) is a cytokine molecule also having pleiotropic anticancerous properties. Previously it has been shown by our group that AAV mediated local (intracranial) gene delivery of human IFNβ (hIFNβ) c

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20

Guhasarkar, Dwijit. "A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation". eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/843.

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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The current standard-of-care treatment including surgery, radiation and temozolomide (TMZ) chemotherapy does not prolong the survival satisfactorily. Here we have tested the feasibility, efficacy and safety of a potential gene therapy approach using AAV as gene delivery vehicle for treatment of GBM. Interferon-beta (IFNβ) is a cytokine molecule also having pleiotropic anticancerous properties. Previously it has been shown by our group that AAV mediated local (intracranial) gene delivery of human IFNβ (hIFNβ) c

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21

PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.

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22

Jindani, Rajika. "Glioblastoma multiforme: etiology, progression, and treatment." Thesis, 2017. https://hdl.handle.net/2144/26730.

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Glioblastoma multiforme is the most common and malignant brain tumor, accounting for more than 52% of all primary brain tumors. The molecular heterogeneity of the tumor has made it difficult to treat, and even more difficult to cure. Due to the high mortality rate associated with the current treatments used, new innovative medical techniques are being explored. Prominent treatments that are currently being investigated are immune based therapies, focused on checkpoint inhibitors and biomarkers, the use of 2-deoxy-D-glucose to initiate tumor cell apoptosis, and the induction of alterations in D

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23

Heydari, Maysam. "Prognosis of Glioblastoma Multiforme Using Textural Properties on MRI." Master's thesis, 2009. http://hdl.handle.net/10048/799.

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This thesis addresses the challenge of prognosis, in terms of survival prediction, for patients with Glioblastoma Multiforme brain tumors. Glioblastoma is the most malignant brain tumor, which has a median survival time of no more than a year. Accurate assessment of prognostic factors is critical in deciding amongst different treatment options and in designing stratified clinical trials. This thesis is motivated by two observations. Firstly, clinicians often refer to properties of glioblastoma tumors based on magnetic resonance images when assessing prognosis. However, clinical data, along wit

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24

Alnaami, Ibrahim. "Evaluation of Concomitant Temozolomide Treatment in Glioblastoma Multiforme Patients in Two Canadian Tertiary Care Centers." Master's thesis, 2010. http://hdl.handle.net/10048/1300.

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The study evaluated the survival of 364 glioblastoma multiforme (GBM) patients who received different modalities of treatment in two Canadian tertiary care centres. Retrospective and prospective databases were utilized to do a retrospective population based cohort study. The thesis question was among treated GBM patients in Edmonton and Halifax; does the survival rate differ with introduction of concomitant temozolomide and radiation therapy (RT) versus non concomitant treatment? Our results indicate that concomitant temozolomide with radiation therapy and surgery was associated with longer s

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25

Xue, Fen. "The hypoxia inducible cell death gene BNIP3 is mutated in glioblastoma multiforme (GBM)." 2005. http://hdl.handle.net/1993/20642.

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26

Tzong-Ming, Hwu, and 胡宗明. "The Growth Inhibition of Retinoic Acid in Human Glioblastoma Multiforme (GBM) Cell Lines." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/47211906821416453080.

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27

Ramirez, Y. P., A. C. Mladek, Roger M. Phillips, et al. "Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth." 2014. http://hdl.handle.net/10454/7235.

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Yes<br>The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multiforme (GBM) cell lines and primary culture models are reported. Dose–response analysis of cultured GBM cells revealed that DP68 is more potent than DP86 and TMZ and that DP68 was effective even in cell lines resistant to TMZ. On the basis of a serial neurosphere assay, DP68 inhibits repopulation of these cultures at low concentrations. The efficacy of these compounds was independent of MGMT and MMR functions. DP68-induced interstrand DNA cross-links were demonstrated with H2O2

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28

Campos, Valenzuela Jaime Alberto. "Classification of Glioblastoma Multiforme Patients Based on an Integrative Multi-Layer Finite Mixture Model System." Doctoral thesis, 2016. https://tud.qucosa.de/id/qucosa%3A32248.

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Glioblastoma multiforme (GMB) is an extremely aggressive and invasive brain cancer with a median survival of less than one year. In addition, due to its anaplastic nature the histological classification of this cancer is not simple. These characteristics make this disease an interesting and important target for new methodologies of analysis and classification. In recent years, molecular information has been used to segregate and analyze GBM patients, but generally this methodology utilizes single-`omic' data to perform the classification or multi-’omic’ data in a sequential manner. In this p

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29

Lin, Tzu-Wei, and 林子瑋. "Investigation of TDP-43/HDAC6 Signaling Pathway Regulated Tumor Progression and Autophagy in Glioblastoma Multiforme (GBM)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/95795262132847194097.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>105<br>Glioblastoma Multiforme (GBM) is a lethal primary brain tumor, which has poor survival lifespan and dismal outcome. Surgical resection of GBM is greatly limited due to the biological significance of brain, giving rise to tumor relapse in GBM patients. GBM bears a dismal prognosis with rapid relapse following complete resection and radiochemotherapy. Despite optimal treatment, high risk of cancer recurrence has been reported. GBM is a fast growing tumor; the center of GBM contains necrosis cells surrounded by growing cancer cells. Therefore, cells, which loc

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30

張君威. "Molecular Pathological Studies of Glioblastoma Multiforme(GBM) of Human Brain by TUNEL, Flow Cytometry and Immunohistochemical Stains." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/00111375634269959553.

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碩士<br>國防醫學院<br>病理及寄生蟲學研究所<br>86<br>Apoptosis is a physiological process which eliminates specific types of cells, and is also called programmed death. Apoptosis plays a key role in determining the size and shape of developing organs, in maintaining the dynamic steady state in the turnover of certain cell lineages in normal tissue, and in defining tumor cell growth pattern. 　　Recently, a new method termed terninal deoxynucleotydil transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) has been introduced to detect apoptotic cells in formalin-fixed, paraffinembedded sections. This proc

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31

Chuang, Ying Ying, and 莊穎瑩. "The effects of Danthron on the cell cycle and apoptosis of human brain glioblastoma multiforms GBM 8401 cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/3jrkh6.

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碩士<br>元培科技大學<br>醫學檢驗生物技術研究所<br>97<br>Danthron (1,8-dihydroxyanthraquinone), one of component from Rheum palmatum L. (Polygonaceae), is an effective component of nature Chinese herb medicine and has been shown several biological activities inclusive of with a powerful anti-tumor activity. For the effects on protein function, Danthron is considered as a tyrosine kinase inhibitor. Danthron can not only inhibit tyrosine kinase signal pathway, proliferation and metastasis ability of cancer cells but induce apoptosis of cancer cells, including lung cancer and breast cancer etc. In addition, Danthron

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Alão, Mariana Neves Ramalho Ferreira. "Deep and transfer learning approaches for glioblastoma patient survival prediction from pre-treatment MRI." Master's thesis, 2019. http://hdl.handle.net/1822/70817.

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Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Eletrónica Médica)<br>Glioblastoma Multiforme (GBM) is a harmful brain tumor with a median overall survival (OS) of only fourteen months. Predicting the OS from pre-treatment Magnetic Resonance Imaging (MRI) is intrinsically tricky not only due to the morphologic characteristics of the tumor but also due to the impact of the treatment. In the last years, deep learning began to arouse the interest of the scientific community due to the excellent performances achieved. In the medical imaging field, the convo

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Facchino, Sabrina. "Rôle du gène Polycomb BMI1 dans le maintien et la radiorésistance des cellules souches cancéreuses." Thèse, 2010. http://hdl.handle.net/1866/4921.

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Le glioblastome multiforme (GBM) est la tumeur cérébrale la plus commune et létale chez l’adulte. Malgré les avancés fulgurantes dans la dernière décennie au niveau des thérapies contre le cancer, le pronostique reste inchangé. Le manque de spécificité des traitements est la cause première de la récurrence de cette tumeur. Une meilleure compréhension au niveau des mécanismes moléculaires et biologiques de cette tumeur est impérative. La découverte des cellules souches cancéreuses (CD133+) au niveau du GBM offre une nouvelle opportunité thérapeutique contre cette tumeur. Effectivement, les cell

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